-- dump date 20140620_054035 -- class Genbank::misc_feature -- table misc_feature_note -- id note 877468000001 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 877468000002 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 877468000003 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 877468000004 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 877468000005 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 877468000006 S-adenosylmethionine binding site [chemical binding]; other site 877468000007 ATP synthase I chain; Region: ATP_synt_I; cl09170 877468000008 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 877468000009 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 877468000010 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 877468000011 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 877468000012 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 877468000013 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 877468000014 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 877468000015 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 877468000016 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 877468000017 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 877468000018 beta subunit interaction interface [polypeptide binding]; other site 877468000019 Walker A motif; other site 877468000020 ATP binding site [chemical binding]; other site 877468000021 Walker B motif; other site 877468000022 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 877468000023 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 877468000024 core domain interface [polypeptide binding]; other site 877468000025 delta subunit interface [polypeptide binding]; other site 877468000026 epsilon subunit interface [polypeptide binding]; other site 877468000027 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 877468000028 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 877468000029 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 877468000030 alpha subunit interaction interface [polypeptide binding]; other site 877468000031 Walker A motif; other site 877468000032 ATP binding site [chemical binding]; other site 877468000033 Walker B motif; other site 877468000034 inhibitor binding site; inhibition site 877468000035 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 877468000036 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 877468000037 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 877468000038 gamma subunit interface [polypeptide binding]; other site 877468000039 epsilon subunit interface [polypeptide binding]; other site 877468000040 LBP interface [polypeptide binding]; other site 877468000041 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 877468000042 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 877468000043 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 877468000044 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 877468000045 Substrate binding site; other site 877468000046 Mg++ binding site; other site 877468000047 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 877468000048 active site 877468000049 substrate binding site [chemical binding]; other site 877468000050 CoA binding site [chemical binding]; other site 877468000051 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 877468000052 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 877468000053 glutaminase active site [active] 877468000054 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 877468000055 dimer interface [polypeptide binding]; other site 877468000056 active site 877468000057 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 877468000058 dimer interface [polypeptide binding]; other site 877468000059 active site 877468000060 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 877468000061 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 877468000062 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 877468000063 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 877468000064 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 877468000065 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 877468000066 shikimate binding site; other site 877468000067 NAD(P) binding site [chemical binding]; other site 877468000068 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 877468000069 active site 877468000070 P-loop; other site 877468000071 phosphorylation site [posttranslational modification] 877468000072 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 877468000073 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 877468000074 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 877468000075 substrate binding pocket [chemical binding]; other site 877468000076 membrane-bound complex binding site; other site 877468000077 hinge residues; other site 877468000078 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 877468000079 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468000080 dimer interface [polypeptide binding]; other site 877468000081 conserved gate region; other site 877468000082 putative PBP binding loops; other site 877468000083 ABC-ATPase subunit interface; other site 877468000084 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 877468000085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468000086 dimer interface [polypeptide binding]; other site 877468000087 conserved gate region; other site 877468000088 putative PBP binding loops; other site 877468000089 ABC-ATPase subunit interface; other site 877468000090 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 877468000091 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 877468000092 Walker A/P-loop; other site 877468000093 ATP binding site [chemical binding]; other site 877468000094 Q-loop/lid; other site 877468000095 ABC transporter signature motif; other site 877468000096 Walker B; other site 877468000097 D-loop; other site 877468000098 H-loop/switch region; other site 877468000099 transcriptional regulator PhoU; Provisional; Region: PRK11115 877468000100 PhoU domain; Region: PhoU; pfam01895 877468000101 PhoU domain; Region: PhoU; pfam01895 877468000102 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 877468000103 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 877468000104 active site 877468000105 motif I; other site 877468000106 motif II; other site 877468000107 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 877468000108 Predicted flavoprotein [General function prediction only]; Region: COG0431 877468000109 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 877468000110 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 877468000111 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 877468000112 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468000113 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 877468000114 substrate binding pocket [chemical binding]; other site 877468000115 dimerization interface [polypeptide binding]; other site 877468000116 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 877468000117 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468000118 putative substrate translocation pore; other site 877468000119 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 877468000120 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 877468000121 trmE is a tRNA modification GTPase; Region: trmE; cd04164 877468000122 G1 box; other site 877468000123 GTP/Mg2+ binding site [chemical binding]; other site 877468000124 Switch I region; other site 877468000125 G2 box; other site 877468000126 Switch II region; other site 877468000127 G3 box; other site 877468000128 G4 box; other site 877468000129 G5 box; other site 877468000130 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 877468000131 membrane protein insertase; Provisional; Region: PRK01318 877468000132 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 877468000133 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 877468000134 ribonuclease P; Reviewed; Region: rnpA; PRK01732 877468000135 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 877468000136 DnaA N-terminal domain; Region: DnaA_N; pfam11638 877468000137 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 877468000138 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 877468000139 Walker A motif; other site 877468000140 ATP binding site [chemical binding]; other site 877468000141 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 877468000142 Walker B motif; other site 877468000143 arginine finger; other site 877468000144 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 877468000145 DnaA box-binding interface [nucleotide binding]; other site 877468000146 DNA polymerase III subunit beta; Validated; Region: PRK05643 877468000147 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 877468000148 putative DNA binding surface [nucleotide binding]; other site 877468000149 dimer interface [polypeptide binding]; other site 877468000150 beta-clamp/clamp loader binding surface; other site 877468000151 beta-clamp/translesion DNA polymerase binding surface; other site 877468000152 recF protein; Region: recf; TIGR00611 877468000153 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 877468000154 Walker A/P-loop; other site 877468000155 ATP binding site [chemical binding]; other site 877468000156 Q-loop/lid; other site 877468000157 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 877468000158 ABC transporter signature motif; other site 877468000159 Walker B; other site 877468000160 D-loop; other site 877468000161 H-loop/switch region; other site 877468000162 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 877468000163 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 877468000164 Mg2+ binding site [ion binding]; other site 877468000165 G-X-G motif; other site 877468000166 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 877468000167 anchoring element; other site 877468000168 dimer interface [polypeptide binding]; other site 877468000169 ATP binding site [chemical binding]; other site 877468000170 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 877468000171 active site 877468000172 putative metal-binding site [ion binding]; other site 877468000173 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 877468000174 Transcriptional regulator [Transcription]; Region: LysR; COG0583 877468000175 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468000176 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 877468000177 putative dimerization interface [polypeptide binding]; other site 877468000178 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 877468000179 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 877468000180 active site pocket [active] 877468000181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468000182 D-galactonate transporter; Region: 2A0114; TIGR00893 877468000183 putative substrate translocation pore; other site 877468000184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468000185 sugar phosphate phosphatase; Provisional; Region: PRK10513 877468000186 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 877468000187 active site 877468000188 motif I; other site 877468000189 motif II; other site 877468000190 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 877468000191 Transcriptional regulators [Transcription]; Region: FadR; COG2186 877468000192 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 877468000193 DNA-binding site [nucleotide binding]; DNA binding site 877468000194 FCD domain; Region: FCD; pfam07729 877468000195 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 877468000196 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 877468000197 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 877468000198 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 877468000199 active site 877468000200 intersubunit interface [polypeptide binding]; other site 877468000201 catalytic residue [active] 877468000202 galactonate dehydratase; Provisional; Region: PRK14017 877468000203 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 877468000204 putative active site pocket [active] 877468000205 putative metal binding site [ion binding]; other site 877468000206 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468000207 D-galactonate transporter; Region: 2A0114; TIGR00893 877468000208 putative substrate translocation pore; other site 877468000209 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 877468000210 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 877468000211 dimer interface [polypeptide binding]; other site 877468000212 phosphorylation site [posttranslational modification] 877468000213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 877468000214 ATP binding site [chemical binding]; other site 877468000215 Mg2+ binding site [ion binding]; other site 877468000216 G-X-G motif; other site 877468000217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 877468000218 active site 877468000219 phosphorylation site [posttranslational modification] 877468000220 intermolecular recognition site; other site 877468000221 dimerization interface [polypeptide binding]; other site 877468000222 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 877468000223 putative binding surface; other site 877468000224 active site 877468000225 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 877468000226 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 877468000227 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 877468000228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 877468000229 active site 877468000230 phosphorylation site [posttranslational modification] 877468000231 intermolecular recognition site; other site 877468000232 dimerization interface [polypeptide binding]; other site 877468000233 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 877468000234 DNA binding site [nucleotide binding] 877468000235 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 877468000236 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 877468000237 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 877468000238 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 877468000239 molybdopterin cofactor binding site [chemical binding]; other site 877468000240 substrate binding site [chemical binding]; other site 877468000241 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 877468000242 molybdopterin cofactor binding site; other site 877468000243 chaperone protein TorD; Validated; Region: torD; PRK04976 877468000244 Haem-binding domain; Region: Haem_bd; pfam14376 877468000245 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 877468000246 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 877468000247 Walker A/P-loop; other site 877468000248 ATP binding site [chemical binding]; other site 877468000249 Q-loop/lid; other site 877468000250 ABC transporter signature motif; other site 877468000251 Walker B; other site 877468000252 D-loop; other site 877468000253 H-loop/switch region; other site 877468000254 heme exporter protein CcmB; Region: ccmB; TIGR01190 877468000255 heme exporter protein CcmC; Region: ccmC; TIGR01191 877468000256 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 877468000257 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150 877468000258 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 877468000259 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 877468000260 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 877468000261 catalytic residues [active] 877468000262 central insert; other site 877468000263 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 877468000264 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 877468000265 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 877468000266 hypothetical protein; Provisional; Region: PRK11616 877468000267 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 877468000268 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 877468000269 putative dimer interface [polypeptide binding]; other site 877468000270 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 877468000271 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 877468000272 putative dimer interface [polypeptide binding]; other site 877468000273 putative transporter; Validated; Region: PRK03818 877468000274 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 877468000275 TrkA-C domain; Region: TrkA_C; pfam02080 877468000276 TrkA-C domain; Region: TrkA_C; pfam02080 877468000277 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 877468000278 Predicted membrane protein [Function unknown]; Region: COG2149 877468000279 Domain of unknown function (DUF202); Region: DUF202; pfam02656 877468000280 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 877468000281 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 877468000282 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 877468000283 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 877468000284 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 877468000285 catalytic residue [active] 877468000286 permease DsdX; Provisional; Region: PRK09921 877468000287 gluconate transporter; Region: gntP; TIGR00791 877468000288 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 877468000289 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468000290 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 877468000291 dimerization interface [polypeptide binding]; other site 877468000292 substrate binding pocket [chemical binding]; other site 877468000293 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 877468000294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468000295 putative substrate translocation pore; other site 877468000296 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 877468000297 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 877468000298 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 877468000299 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 877468000300 PYR/PP interface [polypeptide binding]; other site 877468000301 dimer interface [polypeptide binding]; other site 877468000302 TPP binding site [chemical binding]; other site 877468000303 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 877468000304 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 877468000305 TPP-binding site [chemical binding]; other site 877468000306 dimer interface [polypeptide binding]; other site 877468000307 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 877468000308 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 877468000309 putative valine binding site [chemical binding]; other site 877468000310 dimer interface [polypeptide binding]; other site 877468000311 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 877468000312 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 877468000313 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 877468000314 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 877468000315 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 877468000316 substrate binding site [chemical binding]; other site 877468000317 dimer interface [polypeptide binding]; other site 877468000318 ATP binding site [chemical binding]; other site 877468000319 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 877468000320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468000321 putative substrate translocation pore; other site 877468000322 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 877468000323 active site 877468000324 catalytic residues [active] 877468000325 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 877468000326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 877468000327 active site 877468000328 phosphorylation site [posttranslational modification] 877468000329 intermolecular recognition site; other site 877468000330 dimerization interface [polypeptide binding]; other site 877468000331 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 877468000332 DNA binding residues [nucleotide binding] 877468000333 dimerization interface [polypeptide binding]; other site 877468000334 sensory histidine kinase UhpB; Provisional; Region: PRK11644 877468000335 MASE1; Region: MASE1; pfam05231 877468000336 Histidine kinase; Region: HisKA_3; pfam07730 877468000337 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 877468000338 ATP binding site [chemical binding]; other site 877468000339 Mg2+ binding site [ion binding]; other site 877468000340 G-X-G motif; other site 877468000341 regulatory protein UhpC; Provisional; Region: PRK11663 877468000342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468000343 putative substrate translocation pore; other site 877468000344 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 877468000345 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468000346 putative substrate translocation pore; other site 877468000347 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 877468000348 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 877468000349 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 877468000350 DNA-binding site [nucleotide binding]; DNA binding site 877468000351 UTRA domain; Region: UTRA; pfam07702 877468000352 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 877468000353 active site 877468000354 phosphorylation site [posttranslational modification] 877468000355 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 877468000356 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 877468000357 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 877468000358 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 877468000359 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 877468000360 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 877468000361 putative N- and C-terminal domain interface [polypeptide binding]; other site 877468000362 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 877468000363 putative active site [active] 877468000364 putative carbohydrate binding site [chemical binding]; other site 877468000365 putative MgATP binding site [chemical binding]; other site 877468000366 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 877468000367 intersubunit interface [polypeptide binding]; other site 877468000368 active site 877468000369 zinc binding site [ion binding]; other site 877468000370 Na+ binding site [ion binding]; other site 877468000371 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 877468000372 regulatory protein interface [polypeptide binding]; other site 877468000373 active site 877468000374 regulatory phosphorylation site [posttranslational modification]; other site 877468000375 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737 877468000376 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 877468000377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468000378 putative substrate translocation pore; other site 877468000379 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 877468000380 beta-galactosidase; Region: BGL; TIGR03356 877468000381 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 877468000382 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 877468000383 Walker A motif; other site 877468000384 ATP binding site [chemical binding]; other site 877468000385 Walker B motif; other site 877468000386 arginine finger; other site 877468000387 Transcriptional antiterminator [Transcription]; Region: COG3933 877468000388 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 877468000389 active site 877468000390 active pocket/dimerization site; other site 877468000391 phosphorylation site [posttranslational modification] 877468000392 PRD domain; Region: PRD; pfam00874 877468000393 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 877468000394 active pocket/dimerization site; other site 877468000395 active site 877468000396 phosphorylation site [posttranslational modification] 877468000397 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 877468000398 active site 877468000399 phosphorylation site [posttranslational modification] 877468000400 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 877468000401 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 877468000402 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 877468000403 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 877468000404 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 877468000405 hypothetical protein; Provisional; Region: PRK09956 877468000406 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 877468000407 EamA-like transporter family; Region: EamA; pfam00892 877468000408 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 877468000409 EamA-like transporter family; Region: EamA; pfam00892 877468000410 magnesium transport protein MgtC; Provisional; Region: PRK15385 877468000411 MgtC family; Region: MgtC; pfam02308 877468000412 magnesium-transporting ATPase; Provisional; Region: PRK15122 877468000413 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 877468000414 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 877468000415 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 877468000416 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 877468000417 motif II; other site 877468000418 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 877468000419 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 877468000420 Isochorismatase family; Region: Isochorismatase; pfam00857 877468000421 catalytic triad [active] 877468000422 dimer interface [polypeptide binding]; other site 877468000423 conserved cis-peptide bond; other site 877468000424 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 877468000425 DNA binding site [nucleotide binding] 877468000426 autotransport protein MisL; Provisional; Region: PRK15313 877468000427 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 877468000428 Autotransporter beta-domain; Region: Autotransporter; pfam03797 877468000429 Transposase; Region: HTH_Tnp_1; cl17663 877468000430 putative transporter; Provisional; Region: PRK11462 877468000431 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 877468000432 putative alpha-glucosidase; Provisional; Region: PRK10658 877468000433 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 877468000434 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 877468000435 active site 877468000436 homotrimer interface [polypeptide binding]; other site 877468000437 catalytic site [active] 877468000438 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 877468000439 AsmA family; Region: AsmA; pfam05170 877468000440 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 877468000441 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 877468000442 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 877468000443 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 877468000444 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 877468000445 generic binding surface II; other site 877468000446 ssDNA binding site; other site 877468000447 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 877468000448 ATP binding site [chemical binding]; other site 877468000449 putative Mg++ binding site [ion binding]; other site 877468000450 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 877468000451 nucleotide binding region [chemical binding]; other site 877468000452 ATP-binding site [chemical binding]; other site 877468000453 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 877468000454 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 877468000455 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 877468000456 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 877468000457 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 877468000458 Zn2+ binding site [ion binding]; other site 877468000459 Mg2+ binding site [ion binding]; other site 877468000460 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 877468000461 synthetase active site [active] 877468000462 NTP binding site [chemical binding]; other site 877468000463 metal binding site [ion binding]; metal-binding site 877468000464 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 877468000465 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 877468000466 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 877468000467 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 877468000468 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 877468000469 catalytic site [active] 877468000470 G-X2-G-X-G-K; other site 877468000471 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 877468000472 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 877468000473 nucleotide binding pocket [chemical binding]; other site 877468000474 K-X-D-G motif; other site 877468000475 catalytic site [active] 877468000476 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 877468000477 Predicted membrane protein [Function unknown]; Region: COG2860 877468000478 UPF0126 domain; Region: UPF0126; pfam03458 877468000479 UPF0126 domain; Region: UPF0126; pfam03458 877468000480 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 877468000481 Transcriptional regulator [Transcription]; Region: LysR; COG0583 877468000482 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468000483 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 877468000484 dimerization interface [polypeptide binding]; other site 877468000485 hypothetical protein; Provisional; Region: PRK11820 877468000486 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 877468000487 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 877468000488 ribonuclease PH; Reviewed; Region: rph; PRK00173 877468000489 Ribonuclease PH; Region: RNase_PH_bact; cd11362 877468000490 hexamer interface [polypeptide binding]; other site 877468000491 active site 877468000492 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 877468000493 active site 877468000494 division inhibitor protein; Provisional; Region: slmA; PRK09480 877468000495 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 877468000496 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 877468000497 trimer interface [polypeptide binding]; other site 877468000498 active site 877468000499 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 877468000500 Flavoprotein; Region: Flavoprotein; pfam02441 877468000501 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 877468000502 hypothetical protein; Reviewed; Region: PRK00024 877468000503 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 877468000504 MPN+ (JAMM) motif; other site 877468000505 Zinc-binding site [ion binding]; other site 877468000506 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 877468000507 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 877468000508 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 877468000509 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 877468000510 DNA binding site [nucleotide binding] 877468000511 catalytic residue [active] 877468000512 H2TH interface [polypeptide binding]; other site 877468000513 putative catalytic residues [active] 877468000514 turnover-facilitating residue; other site 877468000515 intercalation triad [nucleotide binding]; other site 877468000516 8OG recognition residue [nucleotide binding]; other site 877468000517 putative reading head residues; other site 877468000518 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 877468000519 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 877468000520 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 877468000521 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 877468000522 active site 877468000523 (T/H)XGH motif; other site 877468000524 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 877468000525 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 877468000526 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 877468000527 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 877468000528 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 877468000529 putative active site [active] 877468000530 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 877468000531 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 877468000532 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 877468000533 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 877468000534 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 877468000535 Ligand binding site; other site 877468000536 metal-binding site 877468000537 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 877468000538 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 877468000539 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 877468000540 putative ADP-binding pocket [chemical binding]; other site 877468000541 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 877468000542 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 877468000543 Ligand binding site; other site 877468000544 metal-binding site 877468000545 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 877468000546 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 877468000547 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 877468000548 Ligand binding site; other site 877468000549 metal-binding site 877468000550 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 877468000551 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176 877468000552 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 877468000553 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 877468000554 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 877468000555 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 877468000556 O-antigen ligase RfaL; Provisional; Region: PRK15487 877468000557 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 877468000558 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 877468000559 putative active site [active] 877468000560 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 877468000561 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 877468000562 putative active site [active] 877468000563 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 877468000564 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 877468000565 NADP binding site [chemical binding]; other site 877468000566 homopentamer interface [polypeptide binding]; other site 877468000567 substrate binding site [chemical binding]; other site 877468000568 active site 877468000569 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 877468000570 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 877468000571 substrate-cofactor binding pocket; other site 877468000572 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468000573 catalytic residue [active] 877468000574 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 877468000575 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 877468000576 NAD(P) binding site [chemical binding]; other site 877468000577 putative glycosyl transferase; Provisional; Region: PRK10073 877468000578 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 877468000579 active site 877468000580 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 877468000581 NodB motif; other site 877468000582 putative active site [active] 877468000583 putative catalytic site [active] 877468000584 Zn binding site [ion binding]; other site 877468000585 AmiB activator; Provisional; Region: PRK11637 877468000586 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 877468000587 Peptidase family M23; Region: Peptidase_M23; pfam01551 877468000588 phosphoglyceromutase; Provisional; Region: PRK05434 877468000589 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 877468000590 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 877468000591 active site residue [active] 877468000592 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 877468000593 GSH binding site [chemical binding]; other site 877468000594 catalytic residues [active] 877468000595 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 877468000596 SecA binding site; other site 877468000597 Preprotein binding site; other site 877468000598 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 877468000599 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 877468000600 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 877468000601 serine acetyltransferase; Provisional; Region: cysE; PRK11132 877468000602 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 877468000603 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 877468000604 trimer interface [polypeptide binding]; other site 877468000605 active site 877468000606 substrate binding site [chemical binding]; other site 877468000607 CoA binding site [chemical binding]; other site 877468000608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468000609 D-galactonate transporter; Region: 2A0114; TIGR00893 877468000610 putative substrate translocation pore; other site 877468000611 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 877468000612 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 877468000613 active site pocket [active] 877468000614 Transcriptional regulators [Transcription]; Region: PurR; COG1609 877468000615 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 877468000616 DNA binding site [nucleotide binding] 877468000617 domain linker motif; other site 877468000618 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 877468000619 putative dimerization interface [polypeptide binding]; other site 877468000620 putative ligand binding site [chemical binding]; other site 877468000621 putative rRNA methylase; Provisional; Region: PRK10358 877468000622 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 877468000623 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 877468000624 active site 877468000625 substrate binding site [chemical binding]; other site 877468000626 FMN binding site [chemical binding]; other site 877468000627 putative catalytic residues [active] 877468000628 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 877468000629 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 877468000630 DNA-binding site [nucleotide binding]; DNA binding site 877468000631 FCD domain; Region: FCD; pfam07729 877468000632 L-lactate permease; Provisional; Region: PRK10420 877468000633 glycolate transporter; Provisional; Region: PRK09695 877468000634 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 877468000635 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 877468000636 trimer interface [polypeptide binding]; other site 877468000637 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 877468000638 Haemagglutinin; Region: HIM; pfam05662 877468000639 Haemagglutinin; Region: HIM; pfam05662 877468000640 YadA-like C-terminal region; Region: YadA; pfam03895 877468000641 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 877468000642 hypothetical protein; Provisional; Region: PRK11020 877468000643 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 877468000644 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 877468000645 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 877468000646 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 877468000647 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 877468000648 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 877468000649 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 877468000650 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 877468000651 active site 877468000652 P-loop; other site 877468000653 phosphorylation site [posttranslational modification] 877468000654 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 877468000655 active site 877468000656 phosphorylation site [posttranslational modification] 877468000657 putative glutathione S-transferase; Provisional; Region: PRK10357 877468000658 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 877468000659 putative C-terminal domain interface [polypeptide binding]; other site 877468000660 putative GSH binding site (G-site) [chemical binding]; other site 877468000661 putative dimer interface [polypeptide binding]; other site 877468000662 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 877468000663 dimer interface [polypeptide binding]; other site 877468000664 N-terminal domain interface [polypeptide binding]; other site 877468000665 putative substrate binding pocket (H-site) [chemical binding]; other site 877468000666 selenocysteine synthase; Provisional; Region: PRK04311 877468000667 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 877468000668 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 877468000669 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 877468000670 catalytic residue [active] 877468000671 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 877468000672 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 877468000673 G1 box; other site 877468000674 putative GEF interaction site [polypeptide binding]; other site 877468000675 GTP/Mg2+ binding site [chemical binding]; other site 877468000676 Switch I region; other site 877468000677 G2 box; other site 877468000678 G3 box; other site 877468000679 Switch II region; other site 877468000680 G4 box; other site 877468000681 G5 box; other site 877468000682 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 877468000683 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 877468000684 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 877468000685 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 877468000686 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 877468000687 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 877468000688 nucleotide binding site [chemical binding]; other site 877468000689 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 877468000690 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 877468000691 NAD(P) binding site [chemical binding]; other site 877468000692 catalytic residues [active] 877468000693 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 877468000694 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 877468000695 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 877468000696 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 877468000697 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 877468000698 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 877468000699 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 877468000700 intersubunit interface [polypeptide binding]; other site 877468000701 active site 877468000702 Zn2+ binding site [ion binding]; other site 877468000703 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 877468000704 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 877468000705 AP (apurinic/apyrimidinic) site pocket; other site 877468000706 DNA interaction; other site 877468000707 Metal-binding active site; metal-binding site 877468000708 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 877468000709 active site 877468000710 dimer interface [polypeptide binding]; other site 877468000711 magnesium binding site [ion binding]; other site 877468000712 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 877468000713 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 877468000714 putative N- and C-terminal domain interface [polypeptide binding]; other site 877468000715 putative active site [active] 877468000716 MgATP binding site [chemical binding]; other site 877468000717 catalytic site [active] 877468000718 metal binding site [ion binding]; metal-binding site 877468000719 putative xylulose binding site [chemical binding]; other site 877468000720 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 877468000721 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 877468000722 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 877468000723 DctM-like transporters; Region: DctM; pfam06808 877468000724 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 877468000725 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 877468000726 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 877468000727 Transcriptional regulator [Transcription]; Region: IclR; COG1414 877468000728 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 877468000729 Bacterial transcriptional regulator; Region: IclR; pfam01614 877468000730 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 877468000731 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 877468000732 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 877468000733 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468000734 homodimer interface [polypeptide binding]; other site 877468000735 catalytic residue [active] 877468000736 alpha-amylase; Reviewed; Region: malS; PRK09505 877468000737 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 877468000738 active site 877468000739 catalytic site [active] 877468000740 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 877468000741 hypothetical protein; Provisional; Region: PRK10356 877468000742 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 877468000743 putative dimerization interface [polypeptide binding]; other site 877468000744 Transcriptional regulators [Transcription]; Region: PurR; COG1609 877468000745 putative ligand binding site [chemical binding]; other site 877468000746 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 877468000747 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 877468000748 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 877468000749 xylose isomerase; Provisional; Region: PRK05474 877468000750 xylose isomerase; Region: xylose_isom_A; TIGR02630 877468000751 xylulokinase; Provisional; Region: PRK15027 877468000752 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 877468000753 N- and C-terminal domain interface [polypeptide binding]; other site 877468000754 active site 877468000755 MgATP binding site [chemical binding]; other site 877468000756 catalytic site [active] 877468000757 metal binding site [ion binding]; metal-binding site 877468000758 xylulose binding site [chemical binding]; other site 877468000759 homodimer interface [polypeptide binding]; other site 877468000760 Predicted membrane protein [Function unknown]; Region: COG4682 877468000761 yiaA/B two helix domain; Region: YiaAB; cl01759 877468000762 yiaA/B two helix domain; Region: YiaAB; cl01759 877468000763 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 877468000764 Acyltransferase family; Region: Acyl_transf_3; pfam01757 877468000765 YsaB-like lipoprotein; Region: YsaB; pfam13983 877468000766 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 877468000767 dimer interface [polypeptide binding]; other site 877468000768 motif 1; other site 877468000769 active site 877468000770 motif 2; other site 877468000771 motif 3; other site 877468000772 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 877468000773 DALR anticodon binding domain; Region: DALR_1; pfam05746 877468000774 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 877468000775 DNA-binding site [nucleotide binding]; DNA binding site 877468000776 RNA-binding motif; other site 877468000777 Predicted transcriptional regulator [Transcription]; Region: COG2944 877468000778 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 877468000779 salt bridge; other site 877468000780 non-specific DNA binding site [nucleotide binding]; other site 877468000781 sequence-specific DNA binding site [nucleotide binding]; other site 877468000782 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 877468000783 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 877468000784 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 877468000785 dimerization interface [polypeptide binding]; other site 877468000786 ligand binding site [chemical binding]; other site 877468000787 NADP binding site [chemical binding]; other site 877468000788 catalytic site [active] 877468000789 putative outer membrane lipoprotein; Provisional; Region: PRK10510 877468000790 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 877468000791 ligand binding site [chemical binding]; other site 877468000792 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 877468000793 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 877468000794 molybdopterin cofactor binding site [chemical binding]; other site 877468000795 substrate binding site [chemical binding]; other site 877468000796 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 877468000797 molybdopterin cofactor binding site; other site 877468000798 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 877468000799 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 877468000800 Coenzyme A binding pocket [chemical binding]; other site 877468000801 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 877468000802 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 877468000803 long polar fimbrial protein LpfA; Provisional; Region: PRK15209 877468000804 long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208 877468000805 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 877468000806 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 877468000807 long polar fimbrial outer membrane usher protein LpfC; Provisional; Region: PRK15207 877468000808 PapC N-terminal domain; Region: PapC_N; pfam13954 877468000809 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 877468000810 PapC C-terminal domain; Region: PapC_C; pfam13953 877468000811 long polar fimbrial protein LpfD; Provisional; Region: PRK15206 877468000812 long polar fimbrial protein LpfE; Provisional; Region: PRK15205 877468000813 phosphoethanolamine transferase; Provisional; Region: PRK11560 877468000814 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 877468000815 Sulfatase; Region: Sulfatase; pfam00884 877468000816 Transcriptional regulators [Transcription]; Region: PurR; COG1609 877468000817 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 877468000818 DNA binding site [nucleotide binding] 877468000819 domain linker motif; other site 877468000820 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_8; cd06287 877468000821 putative dimerization interface [polypeptide binding]; other site 877468000822 putative ligand binding site [chemical binding]; other site 877468000823 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 877468000824 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 877468000825 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 877468000826 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 877468000827 peptide binding site [polypeptide binding]; other site 877468000828 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 877468000829 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468000830 dimer interface [polypeptide binding]; other site 877468000831 conserved gate region; other site 877468000832 putative PBP binding loops; other site 877468000833 ABC-ATPase subunit interface; other site 877468000834 dipeptide transporter; Provisional; Region: PRK10913 877468000835 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 877468000836 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468000837 dimer interface [polypeptide binding]; other site 877468000838 conserved gate region; other site 877468000839 putative PBP binding loops; other site 877468000840 ABC-ATPase subunit interface; other site 877468000841 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 877468000842 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 877468000843 Walker A/P-loop; other site 877468000844 ATP binding site [chemical binding]; other site 877468000845 Q-loop/lid; other site 877468000846 ABC transporter signature motif; other site 877468000847 Walker B; other site 877468000848 D-loop; other site 877468000849 H-loop/switch region; other site 877468000850 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 877468000851 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 877468000852 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 877468000853 Walker A/P-loop; other site 877468000854 ATP binding site [chemical binding]; other site 877468000855 Q-loop/lid; other site 877468000856 ABC transporter signature motif; other site 877468000857 Walker B; other site 877468000858 D-loop; other site 877468000859 H-loop/switch region; other site 877468000860 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 877468000861 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 877468000862 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 877468000863 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 877468000864 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 877468000865 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 877468000866 cellulose synthase operon protein YhjU; Region: cellulose_yhjU; TIGR03368 877468000867 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 877468000868 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 877468000869 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 877468000870 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 877468000871 cell division protein; Provisional; Region: PRK10037 877468000872 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 877468000873 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 877468000874 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 877468000875 DXD motif; other site 877468000876 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 877468000877 PilZ domain; Region: PilZ; pfam07238 877468000878 cellulose synthase regulator protein; Provisional; Region: PRK11114 877468000879 endo-1,4-D-glucanase; Provisional; Region: PRK11097 877468000880 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 877468000881 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 877468000882 TPR motif; other site 877468000883 binding surface 877468000884 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 877468000885 TPR motif; other site 877468000886 binding surface 877468000887 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 877468000888 binding surface 877468000889 TPR motif; other site 877468000890 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 877468000891 putative diguanylate cyclase; Provisional; Region: PRK13561 877468000892 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 877468000893 metal binding site [ion binding]; metal-binding site 877468000894 active site 877468000895 I-site; other site 877468000896 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 877468000897 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 877468000898 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 877468000899 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 877468000900 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 877468000901 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 877468000902 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 877468000903 substrate binding site [chemical binding]; other site 877468000904 ATP binding site [chemical binding]; other site 877468000905 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 877468000906 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 877468000907 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 877468000908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468000909 metabolite-proton symporter; Region: 2A0106; TIGR00883 877468000910 putative substrate translocation pore; other site 877468000911 inner membrane protein YhjD; Region: TIGR00766 877468000912 Transcriptional regulator [Transcription]; Region: LysR; COG0583 877468000913 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468000914 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 877468000915 putative effector binding pocket; other site 877468000916 putative dimerization interface [polypeptide binding]; other site 877468000917 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 877468000918 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 877468000919 active site 877468000920 phosphorylation site [posttranslational modification] 877468000921 dimerization interface [polypeptide binding]; other site 877468000922 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 877468000923 DNA binding residues [nucleotide binding] 877468000924 dimerization interface [polypeptide binding]; other site 877468000925 Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772 877468000926 catalytic residue [active] 877468000927 trehalase; Provisional; Region: treF; PRK13270 877468000928 Trehalase; Region: Trehalase; pfam01204 877468000929 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 877468000930 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 877468000931 DNA-binding site [nucleotide binding]; DNA binding site 877468000932 UTRA domain; Region: UTRA; pfam07702 877468000933 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 877468000934 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 877468000935 putative active site [active] 877468000936 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 877468000937 dimer interface [polypeptide binding]; other site 877468000938 active site 877468000939 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 877468000940 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 877468000941 substrate binding site [chemical binding]; other site 877468000942 ATP binding site [chemical binding]; other site 877468000943 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 877468000944 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 877468000945 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 877468000946 active site 877468000947 homodimer interface [polypeptide binding]; other site 877468000948 homotetramer interface [polypeptide binding]; other site 877468000949 glutathione reductase; Validated; Region: PRK06116 877468000950 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 877468000951 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 877468000952 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 877468000953 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 877468000954 hypothetical protein; Provisional; Region: PRK10215 877468000955 oligopeptidase A; Provisional; Region: PRK10911 877468000956 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 877468000957 active site 877468000958 Zn binding site [ion binding]; other site 877468000959 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 877468000960 S-adenosylmethionine binding site [chemical binding]; other site 877468000961 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 877468000962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468000963 putative substrate translocation pore; other site 877468000964 POT family; Region: PTR2; pfam00854 877468000965 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 877468000966 Ligand Binding Site [chemical binding]; other site 877468000967 universal stress protein UspB; Provisional; Region: PRK04960 877468000968 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 877468000969 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 877468000970 Predicted flavoproteins [General function prediction only]; Region: COG2081 877468000971 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 877468000972 HlyD family secretion protein; Region: HlyD; pfam00529 877468000973 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 877468000974 HlyD family secretion protein; Region: HlyD_3; pfam13437 877468000975 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 877468000976 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 877468000977 Walker A/P-loop; other site 877468000978 ATP binding site [chemical binding]; other site 877468000979 Q-loop/lid; other site 877468000980 ABC transporter signature motif; other site 877468000981 Walker B; other site 877468000982 D-loop; other site 877468000983 H-loop/switch region; other site 877468000984 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 877468000985 Walker A/P-loop; other site 877468000986 ATP binding site [chemical binding]; other site 877468000987 Q-loop/lid; other site 877468000988 ABC transporter signature motif; other site 877468000989 Walker B; other site 877468000990 D-loop; other site 877468000991 H-loop/switch region; other site 877468000992 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 877468000993 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 877468000994 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 877468000995 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 877468000996 nickel responsive regulator; Provisional; Region: PRK02967 877468000997 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 877468000998 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 877468000999 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 877468001000 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 877468001001 Domain of unknown function DUF20; Region: UPF0118; pfam01594 877468001002 major facilitator superfamily transporter; Provisional; Region: PRK05122 877468001003 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468001004 putative substrate translocation pore; other site 877468001005 hypothetical protein; Provisional; Region: PRK11615 877468001006 hypothetical protein; Provisional; Region: PRK11212 877468001007 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 877468001008 CPxP motif; other site 877468001009 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 877468001010 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 877468001011 dimer interface [polypeptide binding]; other site 877468001012 ligand binding site [chemical binding]; other site 877468001013 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 877468001014 dimerization interface [polypeptide binding]; other site 877468001015 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 877468001016 dimer interface [polypeptide binding]; other site 877468001017 putative CheW interface [polypeptide binding]; other site 877468001018 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 877468001019 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 877468001020 metal-binding site [ion binding] 877468001021 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 877468001022 Predicted membrane protein [Function unknown]; Region: COG3714 877468001023 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 877468001024 hypothetical protein; Provisional; Region: PRK10910 877468001025 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 877468001026 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 877468001027 S-adenosylmethionine binding site [chemical binding]; other site 877468001028 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 877468001029 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 877468001030 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 877468001031 P loop; other site 877468001032 GTP binding site [chemical binding]; other site 877468001033 cell division protein FtsE; Provisional; Region: PRK10908 877468001034 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 877468001035 Walker A/P-loop; other site 877468001036 ATP binding site [chemical binding]; other site 877468001037 Q-loop/lid; other site 877468001038 ABC transporter signature motif; other site 877468001039 Walker B; other site 877468001040 D-loop; other site 877468001041 H-loop/switch region; other site 877468001042 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 877468001043 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 877468001044 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 877468001045 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 877468001046 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 877468001047 DNA binding residues [nucleotide binding] 877468001048 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 877468001049 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 877468001050 dimerization interface [polypeptide binding]; other site 877468001051 ligand binding site [chemical binding]; other site 877468001052 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 877468001053 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 877468001054 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 877468001055 dimerization interface [polypeptide binding]; other site 877468001056 ligand binding site [chemical binding]; other site 877468001057 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 877468001058 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 877468001059 TM-ABC transporter signature motif; other site 877468001060 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 877468001061 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 877468001062 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 877468001063 TM-ABC transporter signature motif; other site 877468001064 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 877468001065 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 877468001066 Walker A/P-loop; other site 877468001067 ATP binding site [chemical binding]; other site 877468001068 Q-loop/lid; other site 877468001069 ABC transporter signature motif; other site 877468001070 Walker B; other site 877468001071 D-loop; other site 877468001072 H-loop/switch region; other site 877468001073 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 877468001074 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 877468001075 Walker A/P-loop; other site 877468001076 ATP binding site [chemical binding]; other site 877468001077 Q-loop/lid; other site 877468001078 ABC transporter signature motif; other site 877468001079 Walker B; other site 877468001080 D-loop; other site 877468001081 H-loop/switch region; other site 877468001082 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 877468001083 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 877468001084 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 877468001085 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 877468001086 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 877468001087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468001088 dimer interface [polypeptide binding]; other site 877468001089 conserved gate region; other site 877468001090 putative PBP binding loops; other site 877468001091 ABC-ATPase subunit interface; other site 877468001092 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 877468001093 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468001094 dimer interface [polypeptide binding]; other site 877468001095 conserved gate region; other site 877468001096 ABC-ATPase subunit interface; other site 877468001097 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 877468001098 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 877468001099 Walker A/P-loop; other site 877468001100 ATP binding site [chemical binding]; other site 877468001101 Q-loop/lid; other site 877468001102 ABC transporter signature motif; other site 877468001103 Walker B; other site 877468001104 D-loop; other site 877468001105 H-loop/switch region; other site 877468001106 TOBE domain; Region: TOBE_2; pfam08402 877468001107 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 877468001108 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 877468001109 putative active site [active] 877468001110 catalytic site [active] 877468001111 putative metal binding site [ion binding]; other site 877468001112 hypothetical protein; Provisional; Region: PRK10350 877468001113 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 877468001114 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 877468001115 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 877468001116 active site 877468001117 substrate binding pocket [chemical binding]; other site 877468001118 homodimer interaction site [polypeptide binding]; other site 877468001119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 877468001120 Protein of unknown function, DUF606; Region: DUF606; pfam04657 877468001121 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 877468001122 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 877468001123 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 877468001124 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 877468001125 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 877468001126 substrate binding site [chemical binding]; other site 877468001127 dimer interface [polypeptide binding]; other site 877468001128 ATP binding site [chemical binding]; other site 877468001129 putative acetyltransferase YhhY; Provisional; Region: PRK10140 877468001130 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 877468001131 Coenzyme A binding pocket [chemical binding]; other site 877468001132 putative oxidoreductase; Provisional; Region: PRK10206 877468001133 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 877468001134 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 877468001135 Pirin-related protein [General function prediction only]; Region: COG1741 877468001136 Pirin; Region: Pirin; pfam02678 877468001137 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 877468001138 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 877468001139 DNA binding site [nucleotide binding] 877468001140 domain linker motif; other site 877468001141 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 877468001142 putative ligand binding site [chemical binding]; other site 877468001143 putative dimerization interface [polypeptide binding]; other site 877468001144 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 877468001145 low affinity gluconate transporter; Provisional; Region: PRK10472 877468001146 gluconate transporter; Region: gntP; TIGR00791 877468001147 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 877468001148 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 877468001149 glycogen branching enzyme; Provisional; Region: PRK05402 877468001150 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 877468001151 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 877468001152 active site 877468001153 catalytic site [active] 877468001154 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 877468001155 glycogen debranching enzyme; Provisional; Region: PRK03705 877468001156 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 877468001157 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 877468001158 active site 877468001159 catalytic site [active] 877468001160 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 877468001161 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 877468001162 ligand binding site; other site 877468001163 oligomer interface; other site 877468001164 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 877468001165 dimer interface [polypeptide binding]; other site 877468001166 N-terminal domain interface [polypeptide binding]; other site 877468001167 sulfate 1 binding site; other site 877468001168 glycogen synthase; Provisional; Region: glgA; PRK00654 877468001169 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 877468001170 ADP-binding pocket [chemical binding]; other site 877468001171 homodimer interface [polypeptide binding]; other site 877468001172 glycogen phosphorylase; Provisional; Region: PRK14986 877468001173 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 877468001174 homodimer interface [polypeptide binding]; other site 877468001175 active site pocket [active] 877468001176 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 877468001177 Transcriptional regulator [Transcription]; Region: IclR; COG1414 877468001178 Bacterial transcriptional regulator; Region: IclR; pfam01614 877468001179 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 877468001180 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 877468001181 inhibitor site; inhibition site 877468001182 active site 877468001183 dimer interface [polypeptide binding]; other site 877468001184 catalytic residue [active] 877468001185 Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism / Carbohydrate transport and metabolism]; Region: IlvD; COG0129 877468001186 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468001187 D-galactonate transporter; Region: 2A0114; TIGR00893 877468001188 putative substrate translocation pore; other site 877468001189 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 877468001190 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 877468001191 active site 877468001192 metal binding site [ion binding]; metal-binding site 877468001193 dimer interface [polypeptide binding]; other site 877468001194 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 877468001195 hypothetical protein; Provisional; Region: PRK09781 877468001196 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 877468001197 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 877468001198 active site residue [active] 877468001199 intramembrane serine protease GlpG; Provisional; Region: PRK10907 877468001200 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 877468001201 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 877468001202 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 877468001203 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 877468001204 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 877468001205 transcriptional regulator MalT; Provisional; Region: PRK04841 877468001206 AAA ATPase domain; Region: AAA_16; pfam13191 877468001207 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 877468001208 DNA binding residues [nucleotide binding] 877468001209 dimerization interface [polypeptide binding]; other site 877468001210 maltodextrin phosphorylase; Provisional; Region: PRK14985 877468001211 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 877468001212 homodimer interface [polypeptide binding]; other site 877468001213 active site pocket [active] 877468001214 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 877468001215 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 877468001216 high-affinity gluconate transporter; Provisional; Region: PRK14984 877468001217 gluconate transporter; Region: gntP; TIGR00791 877468001218 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 877468001219 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 877468001220 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 877468001221 DNA utilization protein GntX; Provisional; Region: PRK11595 877468001222 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 877468001223 active site 877468001224 carboxylesterase BioH; Provisional; Region: PRK10349 877468001225 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 877468001226 hypothetical protein; Provisional; Region: PRK09956 877468001227 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 877468001228 FeoC like transcriptional regulator; Region: FeoC; cl17677 877468001229 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 877468001230 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 877468001231 G1 box; other site 877468001232 GTP/Mg2+ binding site [chemical binding]; other site 877468001233 Switch I region; other site 877468001234 G2 box; other site 877468001235 G3 box; other site 877468001236 Switch II region; other site 877468001237 G4 box; other site 877468001238 G5 box; other site 877468001239 Nucleoside recognition; Region: Gate; pfam07670 877468001240 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 877468001241 Nucleoside recognition; Region: Gate; pfam07670 877468001242 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 877468001243 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 877468001244 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 877468001245 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 877468001246 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 877468001247 RNA binding site [nucleotide binding]; other site 877468001248 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 877468001249 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 877468001250 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 877468001251 osmolarity response regulator; Provisional; Region: ompR; PRK09468 877468001252 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 877468001253 active site 877468001254 phosphorylation site [posttranslational modification] 877468001255 intermolecular recognition site; other site 877468001256 dimerization interface [polypeptide binding]; other site 877468001257 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 877468001258 DNA binding site [nucleotide binding] 877468001259 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 877468001260 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 877468001261 dimerization interface [polypeptide binding]; other site 877468001262 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 877468001263 dimer interface [polypeptide binding]; other site 877468001264 phosphorylation site [posttranslational modification] 877468001265 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 877468001266 ATP binding site [chemical binding]; other site 877468001267 G-X-G motif; other site 877468001268 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 877468001269 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 877468001270 active site 877468001271 substrate-binding site [chemical binding]; other site 877468001272 metal-binding site [ion binding] 877468001273 ATP binding site [chemical binding]; other site 877468001274 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 877468001275 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 877468001276 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 877468001277 dimerization interface [polypeptide binding]; other site 877468001278 domain crossover interface; other site 877468001279 redox-dependent activation switch; other site 877468001280 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 877468001281 RNA binding surface [nucleotide binding]; other site 877468001282 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 877468001283 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 877468001284 motif II; other site 877468001285 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 877468001286 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 877468001287 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 877468001288 ADP-ribose binding site [chemical binding]; other site 877468001289 dimer interface [polypeptide binding]; other site 877468001290 active site 877468001291 nudix motif; other site 877468001292 metal binding site [ion binding]; metal-binding site 877468001293 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 877468001294 Transglycosylase; Region: Transgly; pfam00912 877468001295 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 877468001296 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 877468001297 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 877468001298 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 877468001299 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 877468001300 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 877468001301 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 877468001302 shikimate kinase; Reviewed; Region: aroK; PRK00131 877468001303 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 877468001304 ADP binding site [chemical binding]; other site 877468001305 magnesium binding site [ion binding]; other site 877468001306 putative shikimate binding site; other site 877468001307 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 877468001308 active site 877468001309 dimer interface [polypeptide binding]; other site 877468001310 metal binding site [ion binding]; metal-binding site 877468001311 cell division protein DamX; Validated; Region: PRK10905 877468001312 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 877468001313 DNA adenine methylase; Provisional; Region: PRK10904 877468001314 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 877468001315 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 877468001316 substrate binding site [chemical binding]; other site 877468001317 hexamer interface [polypeptide binding]; other site 877468001318 metal binding site [ion binding]; metal-binding site 877468001319 phosphoglycolate phosphatase; Provisional; Region: PRK13222 877468001320 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 877468001321 motif II; other site 877468001322 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 877468001323 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 877468001324 active site 877468001325 HIGH motif; other site 877468001326 dimer interface [polypeptide binding]; other site 877468001327 KMSKS motif; other site 877468001328 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 877468001329 Autotransporter beta-domain; Region: Autotransporter; pfam03797 877468001330 siroheme synthase; Provisional; Region: cysG; PRK10637 877468001331 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 877468001332 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 877468001333 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 877468001334 active site 877468001335 SAM binding site [chemical binding]; other site 877468001336 homodimer interface [polypeptide binding]; other site 877468001337 nitrite transporter NirC; Provisional; Region: PRK11562 877468001338 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 877468001339 nitrite reductase subunit NirD; Provisional; Region: PRK14989 877468001340 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 877468001341 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 877468001342 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 877468001343 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 877468001344 putative transporter; Provisional; Region: PRK03699 877468001345 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468001346 putative substrate translocation pore; other site 877468001347 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 877468001348 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 877468001349 substrate binding site [chemical binding]; other site 877468001350 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 877468001351 cell filamentation protein Fic; Provisional; Region: PRK10347 877468001352 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 877468001353 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 877468001354 glutamine binding [chemical binding]; other site 877468001355 catalytic triad [active] 877468001356 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 877468001357 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 877468001358 inhibitor-cofactor binding pocket; inhibition site 877468001359 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468001360 catalytic residue [active] 877468001361 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 877468001362 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 877468001363 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 877468001364 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 877468001365 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 877468001366 ligand binding site [chemical binding]; other site 877468001367 flexible hinge region; other site 877468001368 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 877468001369 putative switch regulator; other site 877468001370 non-specific DNA interactions [nucleotide binding]; other site 877468001371 DNA binding site [nucleotide binding] 877468001372 sequence specific DNA binding site [nucleotide binding]; other site 877468001373 putative cAMP binding site [chemical binding]; other site 877468001374 OsmC-like protein; Region: OsmC; cl00767 877468001375 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 877468001376 active site 877468001377 hypothetical protein; Provisional; Region: PRK04966 877468001378 putative hydrolase; Provisional; Region: PRK10985 877468001379 putative monooxygenase; Provisional; Region: PRK11118 877468001380 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468001381 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 877468001382 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 877468001383 Walker A/P-loop; other site 877468001384 ATP binding site [chemical binding]; other site 877468001385 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 877468001386 ABC transporter signature motif; other site 877468001387 Walker B; other site 877468001388 D-loop; other site 877468001389 ABC transporter; Region: ABC_tran_2; pfam12848 877468001390 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 877468001391 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 877468001392 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 877468001393 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 877468001394 TrkA-N domain; Region: TrkA_N; pfam02254 877468001395 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 877468001396 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 877468001397 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 877468001398 phi X174 lysis protein; Provisional; Region: PRK02793 877468001399 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 877468001400 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 877468001401 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 877468001402 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 877468001403 YheO-like PAS domain; Region: PAS_6; pfam08348 877468001404 HTH domain; Region: HTH_22; pfam13309 877468001405 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 877468001406 sulfur relay protein TusC; Validated; Region: PRK00211 877468001407 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 877468001408 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 877468001409 S17 interaction site [polypeptide binding]; other site 877468001410 S8 interaction site; other site 877468001411 16S rRNA interaction site [nucleotide binding]; other site 877468001412 streptomycin interaction site [chemical binding]; other site 877468001413 23S rRNA interaction site [nucleotide binding]; other site 877468001414 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 877468001415 30S ribosomal protein S7; Validated; Region: PRK05302 877468001416 elongation factor G; Reviewed; Region: PRK00007 877468001417 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 877468001418 G1 box; other site 877468001419 putative GEF interaction site [polypeptide binding]; other site 877468001420 GTP/Mg2+ binding site [chemical binding]; other site 877468001421 Switch I region; other site 877468001422 G2 box; other site 877468001423 G3 box; other site 877468001424 Switch II region; other site 877468001425 G4 box; other site 877468001426 G5 box; other site 877468001427 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 877468001428 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 877468001429 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 877468001430 elongation factor Tu; Reviewed; Region: PRK00049 877468001431 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 877468001432 G1 box; other site 877468001433 GEF interaction site [polypeptide binding]; other site 877468001434 GTP/Mg2+ binding site [chemical binding]; other site 877468001435 Switch I region; other site 877468001436 G2 box; other site 877468001437 G3 box; other site 877468001438 Switch II region; other site 877468001439 G4 box; other site 877468001440 G5 box; other site 877468001441 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 877468001442 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 877468001443 Antibiotic Binding Site [chemical binding]; other site 877468001444 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 877468001445 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 877468001446 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 877468001447 heme binding site [chemical binding]; other site 877468001448 ferroxidase pore; other site 877468001449 ferroxidase diiron center [ion binding]; other site 877468001450 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 877468001451 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 877468001452 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 877468001453 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 877468001454 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 877468001455 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 877468001456 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 877468001457 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 877468001458 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 877468001459 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 877468001460 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 877468001461 protein-rRNA interface [nucleotide binding]; other site 877468001462 putative translocon binding site; other site 877468001463 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 877468001464 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 877468001465 G-X-X-G motif; other site 877468001466 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 877468001467 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 877468001468 23S rRNA interface [nucleotide binding]; other site 877468001469 5S rRNA interface [nucleotide binding]; other site 877468001470 putative antibiotic binding site [chemical binding]; other site 877468001471 L25 interface [polypeptide binding]; other site 877468001472 L27 interface [polypeptide binding]; other site 877468001473 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 877468001474 23S rRNA interface [nucleotide binding]; other site 877468001475 putative translocon interaction site; other site 877468001476 signal recognition particle (SRP54) interaction site; other site 877468001477 L23 interface [polypeptide binding]; other site 877468001478 trigger factor interaction site; other site 877468001479 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 877468001480 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 877468001481 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 877468001482 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 877468001483 RNA binding site [nucleotide binding]; other site 877468001484 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 877468001485 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 877468001486 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 877468001487 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 877468001488 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 877468001489 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 877468001490 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 877468001491 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 877468001492 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 877468001493 23S rRNA interface [nucleotide binding]; other site 877468001494 5S rRNA interface [nucleotide binding]; other site 877468001495 L27 interface [polypeptide binding]; other site 877468001496 L5 interface [polypeptide binding]; other site 877468001497 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 877468001498 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 877468001499 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 877468001500 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 877468001501 23S rRNA binding site [nucleotide binding]; other site 877468001502 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 877468001503 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 877468001504 SecY translocase; Region: SecY; pfam00344 877468001505 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 877468001506 30S ribosomal protein S13; Region: bact_S13; TIGR03631 877468001507 30S ribosomal protein S11; Validated; Region: PRK05309 877468001508 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 877468001509 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 877468001510 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 877468001511 RNA binding surface [nucleotide binding]; other site 877468001512 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 877468001513 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 877468001514 alphaNTD homodimer interface [polypeptide binding]; other site 877468001515 alphaNTD - beta interaction site [polypeptide binding]; other site 877468001516 alphaNTD - beta' interaction site [polypeptide binding]; other site 877468001517 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 877468001518 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 877468001519 hypothetical protein; Provisional; Region: PRK10203 877468001520 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 877468001521 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 877468001522 DNA binding residues [nucleotide binding] 877468001523 dimer interface [polypeptide binding]; other site 877468001524 metal binding site [ion binding]; metal-binding site 877468001525 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 877468001526 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 877468001527 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 877468001528 TrkA-N domain; Region: TrkA_N; pfam02254 877468001529 TrkA-C domain; Region: TrkA_C; pfam02080 877468001530 TrkA-N domain; Region: TrkA_N; pfam02254 877468001531 TrkA-C domain; Region: TrkA_C; pfam02080 877468001532 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 877468001533 putative RNA binding site [nucleotide binding]; other site 877468001534 16S rRNA methyltransferase B; Provisional; Region: PRK10901 877468001535 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 877468001536 S-adenosylmethionine binding site [chemical binding]; other site 877468001537 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 877468001538 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 877468001539 putative active site [active] 877468001540 substrate binding site [chemical binding]; other site 877468001541 putative cosubstrate binding site; other site 877468001542 catalytic site [active] 877468001543 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 877468001544 substrate binding site [chemical binding]; other site 877468001545 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 877468001546 active site 877468001547 catalytic residues [active] 877468001548 metal binding site [ion binding]; metal-binding site 877468001549 hypothetical protein; Provisional; Region: PRK10736 877468001550 DNA protecting protein DprA; Region: dprA; TIGR00732 877468001551 hypothetical protein; Validated; Region: PRK03430 877468001552 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 877468001553 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 877468001554 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 877468001555 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 877468001556 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 877468001557 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 877468001558 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 877468001559 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 877468001560 shikimate binding site; other site 877468001561 NAD(P) binding site [chemical binding]; other site 877468001562 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 877468001563 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 877468001564 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 877468001565 trimer interface [polypeptide binding]; other site 877468001566 putative metal binding site [ion binding]; other site 877468001567 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 877468001568 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 877468001569 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 877468001570 Coenzyme A binding pocket [chemical binding]; other site 877468001571 homoserine O-succinyltransferase; Provisional; Region: PRK05368 877468001572 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 877468001573 proposed active site lysine [active] 877468001574 conserved cys residue [active] 877468001575 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 877468001576 malate synthase A; Region: malate_syn_A; TIGR01344 877468001577 active site 877468001578 isocitrate lyase; Provisional; Region: PRK15063 877468001579 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 877468001580 tetramer interface [polypeptide binding]; other site 877468001581 active site 877468001582 Mg2+/Mn2+ binding site [ion binding]; other site 877468001583 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 877468001584 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 877468001585 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 877468001586 transcriptional repressor IclR; Provisional; Region: PRK11569 877468001587 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 877468001588 Bacterial transcriptional regulator; Region: IclR; pfam01614 877468001589 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 877468001590 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 877468001591 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 877468001592 substrate binding pocket [chemical binding]; other site 877468001593 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 877468001594 B12 binding site [chemical binding]; other site 877468001595 cobalt ligand [ion binding]; other site 877468001596 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 877468001597 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 877468001598 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 877468001599 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 877468001600 active site pocket [active] 877468001601 oxyanion hole [active] 877468001602 catalytic triad [active] 877468001603 active site nucleophile [active] 877468001604 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 877468001605 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 877468001606 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 877468001607 RNA binding surface [nucleotide binding]; other site 877468001608 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 877468001609 probable active site [active] 877468001610 hypothetical protein; Provisional; Region: PRK10515 877468001611 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 877468001612 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 877468001613 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 877468001614 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 877468001615 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 877468001616 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 877468001617 active site 877468001618 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 877468001619 phosphate binding site [ion binding]; other site 877468001620 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 877468001621 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 877468001622 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 877468001623 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 877468001624 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 877468001625 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 877468001626 Phage-related baseplate assembly protein [General function prediction only]; Region: COG3948 877468001627 Phage baseplate assembly protein W [General function prediction only]; Region: COG3628 877468001628 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 877468001629 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 877468001630 Ligand binding site; other site 877468001631 Putative Catalytic site; other site 877468001632 DXD motif; other site 877468001633 Predicted membrane protein [Function unknown]; Region: COG2246 877468001634 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 877468001635 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 877468001636 Phage protein D [General function prediction only]; Region: COG3500 877468001637 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 877468001638 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 877468001639 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 877468001640 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 877468001641 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 877468001642 Phage tail tube protein FII [General function prediction only]; Region: COG3498 877468001643 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 877468001644 Gp37 protein; Region: Gp37; pfam09646 877468001645 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 877468001646 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 877468001647 N-acetyl-D-glucosamine binding site [chemical binding]; other site 877468001648 catalytic residue [active] 877468001649 Protein of unknown function (DUF4063); Region: DUF4063; pfam13272 877468001650 Mor transcription activator family; Region: Mor; pfam08765 877468001651 aspartate kinase III; Validated; Region: PRK09084 877468001652 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 877468001653 nucleotide binding site [chemical binding]; other site 877468001654 substrate binding site [chemical binding]; other site 877468001655 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 877468001656 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 877468001657 dimer interface [polypeptide binding]; other site 877468001658 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 877468001659 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 877468001660 active site 877468001661 dimer interface [polypeptide binding]; other site 877468001662 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 877468001663 dimer interface [polypeptide binding]; other site 877468001664 active site 877468001665 Exopolysaccharide production protein YjbE; Region: YjbE; pfam11106 877468001666 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 877468001667 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 877468001668 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 877468001669 Predicted membrane protein [Function unknown]; Region: COG3223 877468001670 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 877468001671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468001672 dimer interface [polypeptide binding]; other site 877468001673 conserved gate region; other site 877468001674 putative PBP binding loops; other site 877468001675 ABC-ATPase subunit interface; other site 877468001676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468001677 dimer interface [polypeptide binding]; other site 877468001678 conserved gate region; other site 877468001679 putative PBP binding loops; other site 877468001680 ABC-ATPase subunit interface; other site 877468001681 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 877468001682 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 877468001683 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 877468001684 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 877468001685 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 877468001686 Walker A/P-loop; other site 877468001687 ATP binding site [chemical binding]; other site 877468001688 Q-loop/lid; other site 877468001689 ABC transporter signature motif; other site 877468001690 Walker B; other site 877468001691 D-loop; other site 877468001692 H-loop/switch region; other site 877468001693 TOBE domain; Region: TOBE_2; pfam08402 877468001694 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 877468001695 trimer interface; other site 877468001696 sugar binding site [chemical binding]; other site 877468001697 maltose regulon periplasmic protein; Provisional; Region: PRK10564 877468001698 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 877468001699 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 877468001700 UbiA prenyltransferase family; Region: UbiA; pfam01040 877468001701 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 877468001702 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 877468001703 putative acyl-acceptor binding pocket; other site 877468001704 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 877468001705 LexA repressor; Validated; Region: PRK00215 877468001706 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 877468001707 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 877468001708 Catalytic site [active] 877468001709 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 877468001710 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 877468001711 hypothetical protein; Provisional; Region: PRK10428 877468001712 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 877468001713 metal binding site 2 [ion binding]; metal-binding site 877468001714 putative DNA binding helix; other site 877468001715 metal binding site 1 [ion binding]; metal-binding site 877468001716 dimer interface [polypeptide binding]; other site 877468001717 structural Zn2+ binding site [ion binding]; other site 877468001718 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 877468001719 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 877468001720 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 877468001721 FMN binding site [chemical binding]; other site 877468001722 active site 877468001723 catalytic residues [active] 877468001724 substrate binding site [chemical binding]; other site 877468001725 phage shock protein G; Reviewed; Region: pspG; PRK09459 877468001726 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 877468001727 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 877468001728 NADP binding site [chemical binding]; other site 877468001729 dimer interface [polypeptide binding]; other site 877468001730 replicative DNA helicase; Provisional; Region: PRK08006 877468001731 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 877468001732 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 877468001733 Walker A motif; other site 877468001734 ATP binding site [chemical binding]; other site 877468001735 Walker B motif; other site 877468001736 DNA binding loops [nucleotide binding] 877468001737 alanine racemase; Reviewed; Region: alr; PRK00053 877468001738 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 877468001739 active site 877468001740 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 877468001741 substrate binding site [chemical binding]; other site 877468001742 catalytic residues [active] 877468001743 dimer interface [polypeptide binding]; other site 877468001744 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 877468001745 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 877468001746 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468001747 homodimer interface [polypeptide binding]; other site 877468001748 catalytic residue [active] 877468001749 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 877468001750 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 877468001751 active site 877468001752 motif I; other site 877468001753 motif II; other site 877468001754 Uncharacterized conserved protein [Function unknown]; Region: COG0432 877468001755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 877468001756 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 877468001757 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 877468001758 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 877468001759 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 877468001760 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 877468001761 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 877468001762 dimer interface [polypeptide binding]; other site 877468001763 ssDNA binding site [nucleotide binding]; other site 877468001764 tetramer (dimer of dimers) interface [polypeptide binding]; other site 877468001765 putative single-stranded DNA-binding protein; Region: PHA01740 877468001766 Zinc finger-containing protein; Region: zf-C4H2; pfam10146 877468001767 Outer membrane efflux protein; Region: OEP; pfam02321 877468001768 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 877468001769 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 877468001770 HlyD family secretion protein; Region: HlyD_3; pfam13437 877468001771 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 877468001772 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 877468001773 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 877468001774 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 877468001775 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 877468001776 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 877468001777 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 877468001778 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 877468001779 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 877468001780 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 877468001781 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 877468001782 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 877468001783 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 877468001784 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 877468001785 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 877468001786 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 877468001787 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 877468001788 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 877468001789 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 877468001790 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 877468001791 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 877468001792 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 877468001793 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 877468001794 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 877468001795 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 877468001796 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 877468001797 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 877468001798 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 877468001799 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 877468001800 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 877468001801 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 877468001802 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 877468001803 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 877468001804 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 877468001805 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 877468001806 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 877468001807 Bacterial Ig-like domain (group 3); Region: Big_3_2; pfam12245 877468001808 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 877468001809 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 877468001810 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 877468001811 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 877468001812 Walker A/P-loop; other site 877468001813 ATP binding site [chemical binding]; other site 877468001814 Q-loop/lid; other site 877468001815 ABC transporter signature motif; other site 877468001816 Walker B; other site 877468001817 D-loop; other site 877468001818 H-loop/switch region; other site 877468001819 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 877468001820 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 877468001821 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 877468001822 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 877468001823 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 877468001824 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 877468001825 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 877468001826 DNA binding residues [nucleotide binding] 877468001827 dimer interface [polypeptide binding]; other site 877468001828 [2Fe-2S] cluster binding site [ion binding]; other site 877468001829 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 877468001830 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 877468001831 putative C-terminal domain interface [polypeptide binding]; other site 877468001832 putative GSH binding site (G-site) [chemical binding]; other site 877468001833 putative dimer interface [polypeptide binding]; other site 877468001834 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 877468001835 putative N-terminal domain interface [polypeptide binding]; other site 877468001836 putative dimer interface [polypeptide binding]; other site 877468001837 putative substrate binding pocket (H-site) [chemical binding]; other site 877468001838 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 877468001839 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 877468001840 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 877468001841 Transcriptional regulator [Transcription]; Region: LysR; COG0583 877468001842 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468001843 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 877468001844 putative dimerization interface [polypeptide binding]; other site 877468001845 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 877468001846 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 877468001847 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 877468001848 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 877468001849 Na binding site [ion binding]; other site 877468001850 Predicted membrane protein [Function unknown]; Region: COG3162 877468001851 acetyl-CoA synthetase; Provisional; Region: PRK00174 877468001852 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 877468001853 active site 877468001854 CoA binding site [chemical binding]; other site 877468001855 acyl-activating enzyme (AAE) consensus motif; other site 877468001856 AMP binding site [chemical binding]; other site 877468001857 acetate binding site [chemical binding]; other site 877468001858 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 877468001859 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 877468001860 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 877468001861 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 877468001862 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 877468001863 heme lyase subunit NrfE; Provisional; Region: PRK10369 877468001864 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 877468001865 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 877468001866 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 877468001867 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 877468001868 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 877468001869 Sel1-like repeats; Region: SEL1; smart00671 877468001870 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 877468001871 molybdopterin cofactor binding site; other site 877468001872 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 877468001873 molybdopterin cofactor binding site; other site 877468001874 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 877468001875 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 877468001876 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 877468001877 Coenzyme A binding pocket [chemical binding]; other site 877468001878 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 877468001879 dimer interface [polypeptide binding]; other site 877468001880 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 877468001881 hypothetical protein; Provisional; Region: PRK10220 877468001882 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 877468001883 PhnA protein; Region: PhnA; pfam03831 877468001884 proline/glycine betaine transporter; Provisional; Region: PRK10642 877468001885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468001886 putative substrate translocation pore; other site 877468001887 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 877468001888 sensor protein BasS/PmrB; Provisional; Region: PRK10755 877468001889 HAMP domain; Region: HAMP; pfam00672 877468001890 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 877468001891 dimer interface [polypeptide binding]; other site 877468001892 phosphorylation site [posttranslational modification] 877468001893 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 877468001894 ATP binding site [chemical binding]; other site 877468001895 Mg2+ binding site [ion binding]; other site 877468001896 G-X-G motif; other site 877468001897 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 877468001898 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 877468001899 active site 877468001900 phosphorylation site [posttranslational modification] 877468001901 intermolecular recognition site; other site 877468001902 dimerization interface [polypeptide binding]; other site 877468001903 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 877468001904 DNA binding site [nucleotide binding] 877468001905 putative metal dependent hydrolase; Provisional; Region: PRK11598 877468001906 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 877468001907 Sulfatase; Region: Sulfatase; pfam00884 877468001908 arginine:agmatin antiporter; Provisional; Region: PRK10644 877468001909 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 877468001910 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 877468001911 arginine decarboxylase; Provisional; Region: PRK15029 877468001912 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 877468001913 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 877468001914 homodimer interface [polypeptide binding]; other site 877468001915 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468001916 catalytic residue [active] 877468001917 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 877468001918 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 877468001919 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 877468001920 alpha-galactosidase; Provisional; Region: PRK15076 877468001921 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 877468001922 NAD binding site [chemical binding]; other site 877468001923 sugar binding site [chemical binding]; other site 877468001924 divalent metal binding site [ion binding]; other site 877468001925 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 877468001926 dimer interface [polypeptide binding]; other site 877468001927 melibiose:sodium symporter; Provisional; Region: PRK10429 877468001928 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 877468001929 fumarate hydratase; Provisional; Region: PRK15389 877468001930 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 877468001931 Fumarase C-terminus; Region: Fumerase_C; pfam05683 877468001932 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 877468001933 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 877468001934 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 877468001935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 877468001936 active site 877468001937 phosphorylation site [posttranslational modification] 877468001938 intermolecular recognition site; other site 877468001939 dimerization interface [polypeptide binding]; other site 877468001940 sensory histidine kinase DcuS; Provisional; Region: PRK11086 877468001941 PAS domain; Region: PAS; smart00091 877468001942 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 877468001943 ATP binding site [chemical binding]; other site 877468001944 Mg2+ binding site [ion binding]; other site 877468001945 G-X-G motif; other site 877468001946 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 877468001947 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 877468001948 putative [Fe4-S4] binding site [ion binding]; other site 877468001949 putative molybdopterin cofactor binding site [chemical binding]; other site 877468001950 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 877468001951 putative molybdopterin cofactor binding site; other site 877468001952 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 877468001953 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 877468001954 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 877468001955 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 877468001956 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 877468001957 SdiA-regulated; Region: SdiA-regulated; cd09971 877468001958 putative active site [active] 877468001959 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 877468001960 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 877468001961 DNA binding residues [nucleotide binding] 877468001962 dimerization interface [polypeptide binding]; other site 877468001963 AraC family transcriptional regulator; Provisional; Region: PRK15186 877468001964 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 877468001965 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 877468001966 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 877468001967 Coenzyme A binding pocket [chemical binding]; other site 877468001968 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 877468001969 Uncharacterized conserved protein [Function unknown]; Region: COG5464 877468001970 Adhesin biosynthesis transcription regulatory protein; Region: PapB; cl04012 877468001971 pili assembly chaperone protein SafB; Provisional; Region: PRK15224 877468001972 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 877468001973 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 877468001974 PapC N-terminal domain; Region: PapC_N; pfam13954 877468001975 PapC N-terminal domain; Region: PapC_N; pfam13954 877468001976 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 877468001977 PapC C-terminal domain; Region: PapC_C; pfam13953 877468001978 Enterobacteria AfaD invasin protein; Region: AfaD; cl05376 877468001979 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 877468001980 hinge region; other site 877468001981 alpha helical domain; other site 877468001982 FaeA-like protein; Region: FaeA; pfam04703 877468001983 SdiA-regulated; Region: SdiA-regulated; pfam06977 877468001984 SdiA-regulated; Region: SdiA-regulated; cd09971 877468001985 putative active site [active] 877468001986 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 877468001987 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 877468001988 active site 877468001989 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 877468001990 Methyltransferase domain; Region: Methyltransf_27; pfam13708 877468001991 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 877468001992 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 877468001993 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 877468001994 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 877468001995 putative active site [active] 877468001996 putative NTP binding site [chemical binding]; other site 877468001997 putative nucleic acid binding site [nucleotide binding]; other site 877468001998 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 877468001999 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 877468002000 Protein of unknown function (DUF987); Region: DUF987; pfam06174 877468002001 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 877468002002 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 877468002003 MPN+ (JAMM) motif; other site 877468002004 Zinc-binding site [ion binding]; other site 877468002005 Antirestriction protein; Region: Antirestrict; pfam03230 877468002006 Domain of unknown function (DUF932); Region: DUF932; pfam06067 877468002007 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 877468002008 HTH domain; Region: HTH_11; cl17392 877468002009 WYL domain; Region: WYL; pfam13280 877468002010 Predicted GTPase [General function prediction only]; Region: COG3596 877468002011 YfjP GTPase; Region: YfjP; cd11383 877468002012 G1 box; other site 877468002013 GTP/Mg2+ binding site [chemical binding]; other site 877468002014 Switch I region; other site 877468002015 G2 box; other site 877468002016 Switch II region; other site 877468002017 G3 box; other site 877468002018 G4 box; other site 877468002019 G5 box; other site 877468002020 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 877468002021 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 877468002022 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 877468002023 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 877468002024 ProQ/FINO family; Region: ProQ; pfam04352 877468002025 H-NS histone family; Region: Histone_HNS; pfam00816 877468002026 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 877468002027 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 877468002028 Zn2+ binding site [ion binding]; other site 877468002029 Mg2+ binding site [ion binding]; other site 877468002030 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 877468002031 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 877468002032 Integrase core domain; Region: rve; pfam00665 877468002033 Predicted transcriptional regulators [Transcription]; Region: COG1695 877468002034 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 877468002035 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 877468002036 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 877468002037 Chromate transporter; Region: Chromate_transp; pfam02417 877468002038 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 877468002039 dihydropteroate synthase; Region: DHPS; TIGR01496 877468002040 substrate binding pocket [chemical binding]; other site 877468002041 dimer interface [polypeptide binding]; other site 877468002042 inhibitor binding site; inhibition site 877468002043 aminoglycoside resistance protein; Provisional; Region: PRK13746 877468002044 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 877468002045 active site 877468002046 NTP binding site [chemical binding]; other site 877468002047 metal binding triad [ion binding]; metal-binding site 877468002048 antibiotic binding site [chemical binding]; other site 877468002049 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 877468002050 integrase/recombinase; Provisional; Region: PRK15417 877468002051 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 877468002052 Int/Topo IB signature motif; other site 877468002053 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 877468002054 Domain of unknown function (DUF3330); Region: DUF3330; pfam11809 877468002055 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 877468002056 multiple promoter invertase; Provisional; Region: mpi; PRK13413 877468002057 catalytic residues [active] 877468002058 catalytic nucleophile [active] 877468002059 Presynaptic Site I dimer interface [polypeptide binding]; other site 877468002060 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 877468002061 Synaptic Flat tetramer interface [polypeptide binding]; other site 877468002062 Synaptic Site I dimer interface [polypeptide binding]; other site 877468002063 DNA binding site [nucleotide binding] 877468002064 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 877468002065 beta-lactamase TEM; Provisional; Region: PRK15442 877468002066 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 877468002067 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 877468002068 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 877468002069 Predicted transcriptional regulator [Transcription]; Region: COG2378 877468002070 WYL domain; Region: WYL; pfam13280 877468002071 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 877468002072 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 877468002073 Sulfatase; Region: Sulfatase; pfam00884 877468002074 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 877468002075 TPR motif; other site 877468002076 binding surface 877468002077 integrase; Provisional; Region: PRK09692 877468002078 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 877468002079 active site 877468002080 Int/Topo IB signature motif; other site 877468002081 putative transcriptional regulator; Provisional; Region: PRK11640 877468002082 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 877468002083 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 877468002084 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 877468002085 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 877468002086 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 877468002087 DsbD alpha interface [polypeptide binding]; other site 877468002088 catalytic residues [active] 877468002089 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 877468002090 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 877468002091 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 877468002092 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 877468002093 Aspartase; Region: Aspartase; cd01357 877468002094 active sites [active] 877468002095 tetramer interface [polypeptide binding]; other site 877468002096 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 877468002097 putative transporter; Provisional; Region: PRK11021 877468002098 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 877468002099 oligomerisation interface [polypeptide binding]; other site 877468002100 mobile loop; other site 877468002101 roof hairpin; other site 877468002102 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 877468002103 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 877468002104 ring oligomerisation interface [polypeptide binding]; other site 877468002105 ATP/Mg binding site [chemical binding]; other site 877468002106 stacking interactions; other site 877468002107 hinge regions; other site 877468002108 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 877468002109 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 877468002110 Radical SAM superfamily; Region: Radical_SAM; pfam04055 877468002111 FeS/SAM binding site; other site 877468002112 elongation factor P; Validated; Region: PRK00529 877468002113 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 877468002114 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 877468002115 RNA binding site [nucleotide binding]; other site 877468002116 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 877468002117 RNA binding site [nucleotide binding]; other site 877468002118 Predicted small secreted protein [Function unknown]; Region: COG5510 877468002119 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 877468002120 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 877468002121 DNA binding residues [nucleotide binding] 877468002122 dimerization interface [polypeptide binding]; other site 877468002123 multidrug efflux system protein; Provisional; Region: PRK11431 877468002124 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 877468002125 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 877468002126 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 877468002127 Iron-sulfur protein interface; other site 877468002128 proximal quinone binding site [chemical binding]; other site 877468002129 C-subunit interface; other site 877468002130 distal quinone binding site; other site 877468002131 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 877468002132 D-subunit interface [polypeptide binding]; other site 877468002133 Iron-sulfur protein interface; other site 877468002134 proximal quinone binding site [chemical binding]; other site 877468002135 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 877468002136 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 877468002137 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 877468002138 L-aspartate oxidase; Provisional; Region: PRK06175 877468002139 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 877468002140 poxB regulator PoxA; Provisional; Region: PRK09350 877468002141 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 877468002142 motif 1; other site 877468002143 dimer interface [polypeptide binding]; other site 877468002144 active site 877468002145 motif 2; other site 877468002146 motif 3; other site 877468002147 inner membrane transporter YjeM; Provisional; Region: PRK15238 877468002148 Protein of unknown function (DUF2645); Region: DUF2645; pfam10840 877468002149 putative mechanosensitive channel protein; Provisional; Region: PRK10929 877468002150 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 877468002151 Mechanosensitive ion channel; Region: MS_channel; pfam00924 877468002152 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 877468002153 GTPase RsgA; Reviewed; Region: PRK12288 877468002154 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 877468002155 RNA binding site [nucleotide binding]; other site 877468002156 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 877468002157 GTPase/Zn-binding domain interface [polypeptide binding]; other site 877468002158 GTP/Mg2+ binding site [chemical binding]; other site 877468002159 G4 box; other site 877468002160 G5 box; other site 877468002161 G1 box; other site 877468002162 Switch I region; other site 877468002163 G2 box; other site 877468002164 G3 box; other site 877468002165 Switch II region; other site 877468002166 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 877468002167 catalytic site [active] 877468002168 putative active site [active] 877468002169 putative substrate binding site [chemical binding]; other site 877468002170 dimer interface [polypeptide binding]; other site 877468002171 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 877468002172 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 877468002173 substrate binding pocket [chemical binding]; other site 877468002174 membrane-bound complex binding site; other site 877468002175 hinge residues; other site 877468002176 epoxyqueuosine reductase; Region: TIGR00276 877468002177 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 877468002178 putative carbohydrate kinase; Provisional; Region: PRK10565 877468002179 Uncharacterized conserved protein [Function unknown]; Region: COG0062 877468002180 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 877468002181 putative substrate binding site [chemical binding]; other site 877468002182 putative ATP binding site [chemical binding]; other site 877468002183 ADP-binding protein; Provisional; Region: PRK10646 877468002184 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 877468002185 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 877468002186 active site 877468002187 metal binding site [ion binding]; metal-binding site 877468002188 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 877468002189 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 877468002190 ATP binding site [chemical binding]; other site 877468002191 Mg2+ binding site [ion binding]; other site 877468002192 G-X-G motif; other site 877468002193 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 877468002194 ATP binding site [chemical binding]; other site 877468002195 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 877468002196 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 877468002197 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 877468002198 bacterial Hfq-like; Region: Hfq; cd01716 877468002199 hexamer interface [polypeptide binding]; other site 877468002200 Sm1 motif; other site 877468002201 RNA binding site [nucleotide binding]; other site 877468002202 Sm2 motif; other site 877468002203 GTPase HflX; Provisional; Region: PRK11058 877468002204 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 877468002205 HflX GTPase family; Region: HflX; cd01878 877468002206 G1 box; other site 877468002207 GTP/Mg2+ binding site [chemical binding]; other site 877468002208 Switch I region; other site 877468002209 G2 box; other site 877468002210 G3 box; other site 877468002211 Switch II region; other site 877468002212 G4 box; other site 877468002213 G5 box; other site 877468002214 FtsH protease regulator HflK; Provisional; Region: PRK10930 877468002215 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 877468002216 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 877468002217 FtsH protease regulator HflC; Provisional; Region: PRK11029 877468002218 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 877468002219 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 877468002220 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 877468002221 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 877468002222 GDP-binding site [chemical binding]; other site 877468002223 ACT binding site; other site 877468002224 IMP binding site; other site 877468002225 transcriptional repressor NsrR; Provisional; Region: PRK11014 877468002226 Predicted transcriptional regulator [Transcription]; Region: COG1959 877468002227 exoribonuclease R; Provisional; Region: PRK11642 877468002228 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 877468002229 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 877468002230 RNB domain; Region: RNB; pfam00773 877468002231 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 877468002232 RNA binding site [nucleotide binding]; other site 877468002233 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 877468002234 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 877468002235 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 877468002236 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 877468002237 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 877468002238 Ion channel; Region: Ion_trans_2; pfam07885 877468002239 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 877468002240 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 877468002241 Predicted membrane protein [Function unknown]; Region: COG3766 877468002242 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 877468002243 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 877468002244 Predicted integral membrane protein [Function unknown]; Region: COG5463 877468002245 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 877468002246 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 877468002247 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 877468002248 FAD binding site [chemical binding]; other site 877468002249 substrate binding site [chemical binding]; other site 877468002250 catalytic residues [active] 877468002251 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 877468002252 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 877468002253 esterase; Provisional; Region: PRK10566 877468002254 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 877468002255 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 877468002256 transcriptional repressor UlaR; Provisional; Region: PRK13509 877468002257 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 877468002258 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 877468002259 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 877468002260 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 877468002261 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 877468002262 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 877468002263 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 877468002264 active site 877468002265 P-loop; other site 877468002266 phosphorylation site [posttranslational modification] 877468002267 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 877468002268 active site 877468002269 phosphorylation site [posttranslational modification] 877468002270 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 877468002271 active site 877468002272 dimer interface [polypeptide binding]; other site 877468002273 magnesium binding site [ion binding]; other site 877468002274 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 877468002275 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 877468002276 AP (apurinic/apyrimidinic) site pocket; other site 877468002277 DNA interaction; other site 877468002278 Metal-binding active site; metal-binding site 877468002279 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 877468002280 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 877468002281 intersubunit interface [polypeptide binding]; other site 877468002282 active site 877468002283 Zn2+ binding site [ion binding]; other site 877468002284 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 877468002285 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 877468002286 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 877468002287 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 877468002288 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 877468002289 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 877468002290 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 877468002291 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 877468002292 EamA-like transporter family; Region: EamA; pfam00892 877468002293 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 877468002294 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 877468002295 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 877468002296 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 877468002297 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 877468002298 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 877468002299 DKNYY family; Region: DKNYY; pfam13644 877468002300 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 877468002301 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 877468002302 Hemerythrin-like domain; Region: Hr-like; cd12108 877468002303 Fe binding site [ion binding]; other site 877468002304 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 877468002305 EamA-like transporter family; Region: EamA; pfam00892 877468002306 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 877468002307 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 877468002308 NADP binding site [chemical binding]; other site 877468002309 Predicted transcriptional regulators [Transcription]; Region: COG1733 877468002310 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 877468002311 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 877468002312 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 877468002313 active site 877468002314 metal binding site [ion binding]; metal-binding site 877468002315 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 877468002316 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 877468002317 active site 877468002318 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 877468002319 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 877468002320 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 877468002321 Domain of unknown function DUF21; Region: DUF21; pfam01595 877468002322 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 877468002323 Transporter associated domain; Region: CorC_HlyC; smart01091 877468002324 methionine sulfoxide reductase A; Provisional; Region: PRK00058 877468002325 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 877468002326 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 877468002327 Surface antigen; Region: Bac_surface_Ag; pfam01103 877468002328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 877468002329 Family of unknown function (DUF490); Region: DUF490; pfam04357 877468002330 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 877468002331 dimerization interface [polypeptide binding]; other site 877468002332 putative active site pocket [active] 877468002333 putative catalytic residue [active] 877468002334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468002335 D-galactonate transporter; Region: 2A0114; TIGR00893 877468002336 putative substrate translocation pore; other site 877468002337 putative metallo-dependent hydrolase; Provisional; Region: PRK12394 877468002338 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 877468002339 active site 877468002340 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 877468002341 dimer interface [polypeptide binding]; other site 877468002342 substrate binding site [chemical binding]; other site 877468002343 metal binding sites [ion binding]; metal-binding site 877468002344 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 877468002345 AMP binding site [chemical binding]; other site 877468002346 metal binding site [ion binding]; metal-binding site 877468002347 active site 877468002348 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 877468002349 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 877468002350 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 877468002351 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 877468002352 hypothetical protein; Provisional; Region: PRK05255 877468002353 peptidase PmbA; Provisional; Region: PRK11040 877468002354 cytochrome b562; Provisional; Region: PRK15058 877468002355 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 877468002356 conserved hypothetical protein EF_0830/AHA_3911; Region: EF_0830; TIGR03577 877468002357 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 877468002358 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 877468002359 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 877468002360 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 877468002361 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 877468002362 active site 877468002363 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 877468002364 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 877468002365 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 877468002366 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 877468002367 HTH domain; Region: HTH_11; pfam08279 877468002368 Mga helix-turn-helix domain; Region: Mga; pfam05043 877468002369 PRD domain; Region: PRD; pfam00874 877468002370 PRD domain; Region: PRD; pfam00874 877468002371 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 877468002372 active site 877468002373 P-loop; other site 877468002374 phosphorylation site [posttranslational modification] 877468002375 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 877468002376 active site 877468002377 phosphorylation site [posttranslational modification] 877468002378 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 877468002379 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 877468002380 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 877468002381 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 877468002382 FeS/SAM binding site; other site 877468002383 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 877468002384 ATP cone domain; Region: ATP-cone; pfam03477 877468002385 Class III ribonucleotide reductase; Region: RNR_III; cd01675 877468002386 effector binding site; other site 877468002387 active site 877468002388 Zn binding site [ion binding]; other site 877468002389 glycine loop; other site 877468002390 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 877468002391 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 877468002392 Ca binding site [ion binding]; other site 877468002393 active site 877468002394 catalytic site [active] 877468002395 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 877468002396 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 877468002397 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 877468002398 active site turn [active] 877468002399 phosphorylation site [posttranslational modification] 877468002400 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 877468002401 trehalose repressor; Provisional; Region: treR; PRK09492 877468002402 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 877468002403 DNA binding site [nucleotide binding] 877468002404 domain linker motif; other site 877468002405 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 877468002406 dimerization interface [polypeptide binding]; other site 877468002407 ligand binding site [chemical binding]; other site 877468002408 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 877468002409 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 877468002410 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 877468002411 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 877468002412 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 877468002413 Soluble P-type ATPase [General function prediction only]; Region: COG4087 877468002414 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 877468002415 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 877468002416 homotrimer interaction site [polypeptide binding]; other site 877468002417 putative active site [active] 877468002418 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 877468002419 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 877468002420 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 877468002421 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 877468002422 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 877468002423 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 877468002424 Arginine repressor [Transcription]; Region: ArgR; COG1438 877468002425 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 877468002426 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 877468002427 Predicted membrane protein [Function unknown]; Region: COG1288 877468002428 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 877468002429 ornithine carbamoyltransferase; Validated; Region: PRK02102 877468002430 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 877468002431 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 877468002432 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 877468002433 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 877468002434 putative substrate binding site [chemical binding]; other site 877468002435 nucleotide binding site [chemical binding]; other site 877468002436 nucleotide binding site [chemical binding]; other site 877468002437 homodimer interface [polypeptide binding]; other site 877468002438 arginine deiminase; Provisional; Region: PRK01388 877468002439 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 877468002440 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 877468002441 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 877468002442 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 877468002443 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 877468002444 RNase E inhibitor protein; Provisional; Region: PRK11191 877468002445 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 877468002446 active site 877468002447 dinuclear metal binding site [ion binding]; other site 877468002448 dimerization interface [polypeptide binding]; other site 877468002449 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 877468002450 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 877468002451 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 877468002452 Coenzyme A binding pocket [chemical binding]; other site 877468002453 Predicted membrane protein [Function unknown]; Region: COG4269 877468002454 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 877468002455 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 877468002456 HIGH motif; other site 877468002457 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 877468002458 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 877468002459 active site 877468002460 KMSKS motif; other site 877468002461 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 877468002462 tRNA binding surface [nucleotide binding]; other site 877468002463 anticodon binding site; other site 877468002464 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 877468002465 DNA polymerase III subunit chi; Validated; Region: PRK05728 877468002466 multifunctional aminopeptidase A; Provisional; Region: PRK00913 877468002467 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 877468002468 interface (dimer of trimers) [polypeptide binding]; other site 877468002469 Substrate-binding/catalytic site; other site 877468002470 Zn-binding sites [ion binding]; other site 877468002471 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 877468002472 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 877468002473 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 877468002474 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 877468002475 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 877468002476 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 877468002477 DNA binding site [nucleotide binding] 877468002478 domain linker motif; other site 877468002479 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 877468002480 putative dimerization interface [polypeptide binding]; other site 877468002481 putative ligand binding site [chemical binding]; other site 877468002482 gluconate transporter; Region: gntP; TIGR00791 877468002483 fructuronate transporter; Provisional; Region: PRK10034; cl15264 877468002484 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 877468002485 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 877468002486 NADP binding site [chemical binding]; other site 877468002487 homodimer interface [polypeptide binding]; other site 877468002488 active site 877468002489 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 877468002490 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 877468002491 putative NAD(P) binding site [chemical binding]; other site 877468002492 catalytic Zn binding site [ion binding]; other site 877468002493 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 877468002494 ATP-binding site [chemical binding]; other site 877468002495 Gluconate-6-phosphate binding site [chemical binding]; other site 877468002496 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 877468002497 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 877468002498 putative NAD(P) binding site [chemical binding]; other site 877468002499 putative substrate binding site [chemical binding]; other site 877468002500 catalytic Zn binding site [ion binding]; other site 877468002501 structural Zn binding site [ion binding]; other site 877468002502 dimer interface [polypeptide binding]; other site 877468002503 integrase; Provisional; Region: PRK09692 877468002504 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 877468002505 active site 877468002506 Int/Topo IB signature motif; other site 877468002507 DEAD-like helicases superfamily; Region: DEXDc; smart00487 877468002508 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 877468002509 ATP binding site [chemical binding]; other site 877468002510 putative Mg++ binding site [ion binding]; other site 877468002511 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 877468002512 nucleotide binding region [chemical binding]; other site 877468002513 ATP-binding site [chemical binding]; other site 877468002514 Domain of unknown function (DUF1837); Region: DUF1837; pfam08878 877468002515 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 877468002516 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 877468002517 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 877468002518 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 877468002519 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 877468002520 active site 877468002521 metal binding site [ion binding]; metal-binding site 877468002522 interdomain interaction site; other site 877468002523 D5 N terminal like; Region: D5_N; smart00885 877468002524 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 877468002525 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 877468002526 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 877468002527 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 877468002528 HNH endonuclease; Region: HNH_2; pfam13391 877468002529 hypothetical protein; Provisional; Region: PRK12378 877468002530 Methyltransferase domain; Region: Methyltransf_23; pfam13489 877468002531 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 877468002532 S-adenosylmethionine binding site [chemical binding]; other site 877468002533 Methyltransferase domain; Region: Methyltransf_31; pfam13847 877468002534 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 877468002535 S-adenosylmethionine binding site [chemical binding]; other site 877468002536 hypothetical protein; Provisional; Region: PRK13687 877468002537 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 877468002538 Uncharacterized conserved protein [Function unknown]; Region: COG3439 877468002539 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 877468002540 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 877468002541 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 877468002542 DNA-binding site [nucleotide binding]; DNA binding site 877468002543 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 877468002544 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 877468002545 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 877468002546 active site 877468002547 HIGH motif; other site 877468002548 dimer interface [polypeptide binding]; other site 877468002549 KMSKS motif; other site 877468002550 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 877468002551 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 877468002552 aspartate racemase; Region: asp_race; TIGR00035 877468002553 cell density-dependent motility repressor; Provisional; Region: PRK10082 877468002554 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468002555 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 877468002556 dimerization interface [polypeptide binding]; other site 877468002557 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 877468002558 isoaspartyl dipeptidase; Provisional; Region: PRK10657 877468002559 dimer interface [polypeptide binding]; other site 877468002560 active site 877468002561 hypothetical protein; Provisional; Region: PRK10519 877468002562 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 877468002563 Nucleoside recognition; Region: Gate; pfam07670 877468002564 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 877468002565 Predicted membrane protein [Function unknown]; Region: COG2733 877468002566 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 877468002567 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468002568 putative substrate translocation pore; other site 877468002569 hypothetical protein; Provisional; Region: PRK09956 877468002570 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 877468002571 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 877468002572 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 877468002573 NAD(P) binding site [chemical binding]; other site 877468002574 catalytic residues [active] 877468002575 Protein of unknown function DUF91; Region: DUF91; cl00709 877468002576 Uncharacterized conserved protein [Function unknown]; Region: COG3586 877468002577 Uncharacterized conserved protein [Function unknown]; Region: COG1479 877468002578 Protein of unknown function DUF262; Region: DUF262; pfam03235 877468002579 Uncharacterized conserved protein [Function unknown]; Region: COG3472 877468002580 endoribonuclease SymE; Provisional; Region: PRK13605 877468002581 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 877468002582 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 877468002583 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 877468002584 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 877468002585 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 877468002586 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 877468002587 HsdM N-terminal domain; Region: HsdM_N; pfam12161 877468002588 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 877468002589 Methyltransferase domain; Region: Methyltransf_26; pfam13659 877468002590 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 877468002591 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 877468002592 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 877468002593 ATP binding site [chemical binding]; other site 877468002594 putative Mg++ binding site [ion binding]; other site 877468002595 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 877468002596 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 877468002597 P-loop, Walker A motif; other site 877468002598 Base recognition motif; other site 877468002599 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 877468002600 Uncharacterized small protein [Function unknown]; Region: COG2879 877468002601 carbon starvation protein A; Provisional; Region: PRK15015 877468002602 Carbon starvation protein CstA; Region: CstA; pfam02554 877468002603 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 877468002604 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 877468002605 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 877468002606 dimer interface [polypeptide binding]; other site 877468002607 ligand binding site [chemical binding]; other site 877468002608 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 877468002609 dimerization interface [polypeptide binding]; other site 877468002610 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 877468002611 dimer interface [polypeptide binding]; other site 877468002612 putative CheW interface [polypeptide binding]; other site 877468002613 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 877468002614 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 877468002615 Walker A motif; other site 877468002616 ATP binding site [chemical binding]; other site 877468002617 Walker B motif; other site 877468002618 arginine finger; other site 877468002619 Transcriptional antiterminator [Transcription]; Region: COG3933 877468002620 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 877468002621 active pocket/dimerization site; other site 877468002622 active site 877468002623 phosphorylation site [posttranslational modification] 877468002624 PRD domain; Region: PRD; pfam00874 877468002625 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 877468002626 active pocket/dimerization site; other site 877468002627 active site 877468002628 phosphorylation site [posttranslational modification] 877468002629 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 877468002630 active site 877468002631 phosphorylation site [posttranslational modification] 877468002632 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 877468002633 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 877468002634 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 877468002635 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 877468002636 dimer interface [polypeptide binding]; other site 877468002637 active site 877468002638 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 877468002639 dimer interface [polypeptide binding]; other site 877468002640 active site 877468002641 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 877468002642 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 877468002643 putative active site [active] 877468002644 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 877468002645 phosphoglycerol transferase I; Provisional; Region: PRK03776 877468002646 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 877468002647 hypothetical protein; Provisional; Region: PRK11667 877468002648 DNA replication protein DnaC; Validated; Region: PRK07952 877468002649 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 877468002650 Walker A motif; other site 877468002651 ATP binding site [chemical binding]; other site 877468002652 Walker B motif; other site 877468002653 primosomal protein DnaI; Provisional; Region: PRK02854 877468002654 hypothetical protein; Provisional; Region: PRK09917 877468002655 Uncharacterized conserved protein [Function unknown]; Region: COG2966 877468002656 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 877468002657 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 877468002658 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 877468002659 DNA binding residues [nucleotide binding] 877468002660 dimerization interface [polypeptide binding]; other site 877468002661 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 877468002662 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 877468002663 DNA binding residues [nucleotide binding] 877468002664 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 877468002665 putative deacylase active site [active] 877468002666 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 877468002667 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 877468002668 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 877468002669 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 877468002670 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 877468002671 metal binding site [ion binding]; metal-binding site 877468002672 active site 877468002673 I-site; other site 877468002674 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 877468002675 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 877468002676 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 877468002677 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 877468002678 S-adenosylmethionine binding site [chemical binding]; other site 877468002679 DNA polymerase III subunit psi; Validated; Region: PRK06856 877468002680 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 877468002681 Coenzyme A binding pocket [chemical binding]; other site 877468002682 dUMP phosphatase; Provisional; Region: PRK09449 877468002683 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 877468002684 motif II; other site 877468002685 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 877468002686 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 877468002687 G1 box; other site 877468002688 putative GEF interaction site [polypeptide binding]; other site 877468002689 GTP/Mg2+ binding site [chemical binding]; other site 877468002690 Switch I region; other site 877468002691 G2 box; other site 877468002692 G3 box; other site 877468002693 Switch II region; other site 877468002694 G4 box; other site 877468002695 G5 box; other site 877468002696 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 877468002697 periplasmic protein; Provisional; Region: PRK10568 877468002698 BON domain; Region: BON; pfam04972 877468002699 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 877468002700 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 877468002701 active site 877468002702 nucleophile elbow; other site 877468002703 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 877468002704 active site 877468002705 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 877468002706 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 877468002707 FeS/SAM binding site; other site 877468002708 hypothetical protein; Provisional; Region: PRK10977 877468002709 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 877468002710 intersubunit interface [polypeptide binding]; other site 877468002711 active site 877468002712 catalytic residue [active] 877468002713 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 877468002714 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 877468002715 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 877468002716 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 877468002717 phosphopentomutase; Provisional; Region: PRK05362 877468002718 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 877468002719 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 877468002720 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 877468002721 hypothetical protein; Provisional; Region: PRK15301 877468002722 putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304 877468002723 PapC N-terminal domain; Region: PapC_N; pfam13954 877468002724 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 877468002725 PapC C-terminal domain; Region: PapC_C; pfam13953 877468002726 putative fimbrial chaperone protein; Provisional; Region: PRK09918 877468002727 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 877468002728 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 877468002729 hypothetical protein; Provisional; Region: PRK15302 877468002730 hypothetical protein; Provisional; Region: PRK15303 877468002731 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 877468002732 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 877468002733 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 877468002734 hypothetical protein; Provisional; Region: PRK11246 877468002735 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 877468002736 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 877468002737 motif II; other site 877468002738 DNA repair protein RadA; Region: sms; TIGR00416 877468002739 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 877468002740 Walker A motif/ATP binding site; other site 877468002741 ATP binding site [chemical binding]; other site 877468002742 Walker B motif; other site 877468002743 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 877468002744 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 877468002745 non-specific DNA binding site [nucleotide binding]; other site 877468002746 salt bridge; other site 877468002747 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 877468002748 sequence-specific DNA binding site [nucleotide binding]; other site 877468002749 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 877468002750 active site 877468002751 (T/H)XGH motif; other site 877468002752 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 877468002753 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 877468002754 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 877468002755 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 877468002756 ABC transporter; Region: ABC_tran_2; pfam12848 877468002757 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 877468002758 lytic murein transglycosylase; Provisional; Region: PRK11619 877468002759 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 877468002760 N-acetyl-D-glucosamine binding site [chemical binding]; other site 877468002761 catalytic residue [active] 877468002762 Trp operon repressor; Provisional; Region: PRK01381 877468002763 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 877468002764 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 877468002765 catalytic core [active] 877468002766 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 877468002767 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 877468002768 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 877468002769 hypothetical protein; Provisional; Region: PRK10756 877468002770 CreA protein; Region: CreA; pfam05981 877468002771 DNA-binding response regulator CreB; Provisional; Region: PRK11083 877468002772 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 877468002773 active site 877468002774 phosphorylation site [posttranslational modification] 877468002775 intermolecular recognition site; other site 877468002776 dimerization interface [polypeptide binding]; other site 877468002777 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 877468002778 DNA binding site [nucleotide binding] 877468002779 sensory histidine kinase CreC; Provisional; Region: PRK11100 877468002780 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 877468002781 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 877468002782 dimer interface [polypeptide binding]; other site 877468002783 phosphorylation site [posttranslational modification] 877468002784 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 877468002785 ATP binding site [chemical binding]; other site 877468002786 Mg2+ binding site [ion binding]; other site 877468002787 G-X-G motif; other site 877468002788 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 877468002789 putative major fimbrial protein SthE; Provisional; Region: PRK15292 877468002790 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 877468002791 putative fimbrial protein SthD; Provisional; Region: PRK15293 877468002792 putative fimbrial outer membrane usher protein SthC; Provisional; Region: PRK15294 877468002793 PapC N-terminal domain; Region: PapC_N; pfam13954 877468002794 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 877468002795 PapC C-terminal domain; Region: PapC_C; pfam13953 877468002796 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 877468002797 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 877468002798 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 877468002799 putative fimbrial protein SthA; Provisional; Region: PRK15296 877468002800 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 877468002801 Helix-turn-helix domain; Region: HTH_36; pfam13730 877468002802 two-component response regulator; Provisional; Region: PRK11173 877468002803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 877468002804 active site 877468002805 phosphorylation site [posttranslational modification] 877468002806 intermolecular recognition site; other site 877468002807 dimerization interface [polypeptide binding]; other site 877468002808 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 877468002809 DNA binding site [nucleotide binding] 877468002810 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 877468002811 putative RNA methyltransferase; Provisional; Region: PRK10433 877468002812 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 877468002813 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 877468002814 putative catalytic residues [active] 877468002815 putative nucleotide binding site [chemical binding]; other site 877468002816 putative aspartate binding site [chemical binding]; other site 877468002817 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 877468002818 dimer interface [polypeptide binding]; other site 877468002819 putative threonine allosteric regulatory site; other site 877468002820 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 877468002821 putative threonine allosteric regulatory site; other site 877468002822 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 877468002823 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 877468002824 homoserine kinase; Provisional; Region: PRK01212 877468002825 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 877468002826 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 877468002827 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 877468002828 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468002829 catalytic residue [active] 877468002830 hypothetical protein; Validated; Region: PRK02101 877468002831 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 877468002832 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 877468002833 transaldolase-like protein; Provisional; Region: PTZ00411 877468002834 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 877468002835 active site 877468002836 dimer interface [polypeptide binding]; other site 877468002837 catalytic residue [active] 877468002838 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 877468002839 MPT binding site; other site 877468002840 trimer interface [polypeptide binding]; other site 877468002841 hypothetical protein; Provisional; Region: PRK10659 877468002842 hypothetical protein; Provisional; Region: PRK10236 877468002843 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 877468002844 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 877468002845 Protein of unknown function (DUF2541); Region: DUF2541; cl08090 877468002846 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 877468002847 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 877468002848 nucleotide binding site [chemical binding]; other site 877468002849 chaperone protein DnaJ; Provisional; Region: PRK10767 877468002850 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 877468002851 HSP70 interaction site [polypeptide binding]; other site 877468002852 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 877468002853 substrate binding site [polypeptide binding]; other site 877468002854 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 877468002855 Zn binding sites [ion binding]; other site 877468002856 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 877468002857 dimer interface [polypeptide binding]; other site 877468002858 Transcriptional regulator [Transcription]; Region: LysR; COG0583 877468002859 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468002860 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 877468002861 substrate binding pocket [chemical binding]; other site 877468002862 dimerization interface [polypeptide binding]; other site 877468002863 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 877468002864 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 877468002865 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 877468002866 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 877468002867 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 877468002868 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 877468002869 active site 877468002870 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 877468002871 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 877468002872 aromatic chitin/cellulose binding site residues [chemical binding]; other site 877468002873 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 877468002874 Helix-turn-helix domain; Region: HTH_36; pfam13730 877468002875 fimbrial protein BcfA; Provisional; Region: PRK15187 877468002876 fimbrial chaperone protein BcfB; Provisional; Region: PRK15188 877468002877 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 877468002878 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 877468002879 outer membrane usher protein; Provisional; Region: PRK15193 877468002880 PapC N-terminal domain; Region: PapC_N; pfam13954 877468002881 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 877468002882 PapC C-terminal domain; Region: PapC_C; pfam13953 877468002883 fimbrial protein BcfD; Provisional; Region: PRK15189 877468002884 fimbrial protein BcfE; Provisional; Region: PRK15190 877468002885 fimbrial protein BcfF; Provisional; Region: PRK15191 877468002886 fimbrial chaperone BcfG; Provisional; Region: PRK15192 877468002887 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 877468002888 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 877468002889 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 877468002890 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 877468002891 catalytic residues [active] 877468002892 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 877468002893 Transcriptional regulator [Transcription]; Region: LysR; COG0583 877468002894 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468002895 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 877468002896 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 877468002897 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 877468002898 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 877468002899 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 877468002900 active site 877468002901 metal binding site [ion binding]; metal-binding site 877468002902 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 877468002903 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502 877468002904 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 877468002905 Sulfatase; Region: Sulfatase; pfam00884 877468002906 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 877468002907 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 877468002908 FeS/SAM binding site; other site 877468002909 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 877468002910 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 877468002911 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 877468002912 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 877468002913 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 877468002914 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468002915 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 877468002916 putative dimerization interface [polypeptide binding]; other site 877468002917 putative alpha-glucosidase; Provisional; Region: PRK10658 877468002918 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 877468002919 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 877468002920 putative active site [active] 877468002921 putative catalytic site [active] 877468002922 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 877468002923 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 877468002924 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 877468002925 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 877468002926 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 877468002927 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 877468002928 active site 877468002929 Riboflavin kinase; Region: Flavokinase; smart00904 877468002930 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 877468002931 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 877468002932 active site 877468002933 HIGH motif; other site 877468002934 nucleotide binding site [chemical binding]; other site 877468002935 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 877468002936 active site 877468002937 KMSKS motif; other site 877468002938 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 877468002939 tRNA binding surface [nucleotide binding]; other site 877468002940 anticodon binding site; other site 877468002941 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 877468002942 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 877468002943 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 877468002944 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 877468002945 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 877468002946 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 877468002947 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 877468002948 active site 877468002949 tetramer interface [polypeptide binding]; other site 877468002950 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 877468002951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 877468002952 active site 877468002953 phosphorylation site [posttranslational modification] 877468002954 intermolecular recognition site; other site 877468002955 dimerization interface [polypeptide binding]; other site 877468002956 Transcriptional regulator; Region: CitT; pfam12431 877468002957 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 877468002958 PAS domain; Region: PAS; smart00091 877468002959 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 877468002960 ATP binding site [chemical binding]; other site 877468002961 Mg2+ binding site [ion binding]; other site 877468002962 G-X-G motif; other site 877468002963 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 877468002964 oxaloacetate decarboxylase; Provisional; Region: PRK14040 877468002965 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 877468002966 active site 877468002967 catalytic residues [active] 877468002968 metal binding site [ion binding]; metal-binding site 877468002969 homodimer binding site [polypeptide binding]; other site 877468002970 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 877468002971 carboxyltransferase (CT) interaction site; other site 877468002972 biotinylation site [posttranslational modification]; other site 877468002973 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 877468002974 Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493 877468002975 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 877468002976 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 877468002977 putative active site [active] 877468002978 (T/H)XGH motif; other site 877468002979 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 877468002980 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 877468002981 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 877468002982 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 877468002983 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 877468002984 triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125 877468002985 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 877468002986 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 877468002987 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 877468002988 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 877468002989 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 877468002990 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 877468002991 catalytic site [active] 877468002992 subunit interface [polypeptide binding]; other site 877468002993 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 877468002994 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 877468002995 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 877468002996 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 877468002997 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 877468002998 ATP-grasp domain; Region: ATP-grasp_4; cl17255 877468002999 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 877468003000 IMP binding site; other site 877468003001 dimer interface [polypeptide binding]; other site 877468003002 interdomain contacts; other site 877468003003 partial ornithine binding site; other site 877468003004 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 877468003005 carnitine operon protein CaiE; Provisional; Region: PRK13627 877468003006 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 877468003007 putative trimer interface [polypeptide binding]; other site 877468003008 putative metal binding site [ion binding]; other site 877468003009 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 877468003010 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 877468003011 substrate binding site [chemical binding]; other site 877468003012 oxyanion hole (OAH) forming residues; other site 877468003013 trimer interface [polypeptide binding]; other site 877468003014 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 877468003015 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 877468003016 acyl-activating enzyme (AAE) consensus motif; other site 877468003017 putative AMP binding site [chemical binding]; other site 877468003018 putative active site [active] 877468003019 putative CoA binding site [chemical binding]; other site 877468003020 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 877468003021 CoA-transferase family III; Region: CoA_transf_3; pfam02515 877468003022 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 877468003023 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 877468003024 active site 877468003025 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 877468003026 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 877468003027 Ligand binding site [chemical binding]; other site 877468003028 Electron transfer flavoprotein domain; Region: ETF; pfam01012 877468003029 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 877468003030 Electron transfer flavoprotein domain; Region: ETF; smart00893 877468003031 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 877468003032 putative oxidoreductase FixC; Provisional; Region: PRK10157 877468003033 ferredoxin-like protein FixX; Provisional; Region: PRK15449 877468003034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468003035 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 877468003036 putative substrate translocation pore; other site 877468003037 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 877468003038 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 877468003039 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 877468003040 Sulfatase; Region: Sulfatase; cl17466 877468003041 Sulfatase; Region: Sulfatase; cl17466 877468003042 Sulfatase; Region: Sulfatase; cl17466 877468003043 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 877468003044 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 877468003045 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 877468003046 TrkA-N domain; Region: TrkA_N; pfam02254 877468003047 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 877468003048 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 877468003049 folate binding site [chemical binding]; other site 877468003050 NADP+ binding site [chemical binding]; other site 877468003051 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 877468003052 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 877468003053 active site 877468003054 metal binding site [ion binding]; metal-binding site 877468003055 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 877468003056 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 877468003057 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 877468003058 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 877468003059 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 877468003060 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 877468003061 SurA N-terminal domain; Region: SurA_N; pfam09312 877468003062 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 877468003063 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 877468003064 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 877468003065 OstA-like protein; Region: OstA; pfam03968 877468003066 Organic solvent tolerance protein; Region: OstA_C; pfam04453 877468003067 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 877468003068 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 877468003069 putative metal binding site [ion binding]; other site 877468003070 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 877468003071 HSP70 interaction site [polypeptide binding]; other site 877468003072 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 877468003073 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 877468003074 active site 877468003075 ATP-dependent helicase HepA; Validated; Region: PRK04914 877468003076 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 877468003077 ATP binding site [chemical binding]; other site 877468003078 putative Mg++ binding site [ion binding]; other site 877468003079 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 877468003080 nucleotide binding region [chemical binding]; other site 877468003081 ATP-binding site [chemical binding]; other site 877468003082 DNA polymerase II; Reviewed; Region: PRK05762 877468003083 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 877468003084 active site 877468003085 catalytic site [active] 877468003086 substrate binding site [chemical binding]; other site 877468003087 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 877468003088 active site 877468003089 metal-binding site 877468003090 Uncharacterized conserved protein [Function unknown]; Region: COG1434 877468003091 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 877468003092 putative active site [active] 877468003093 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 877468003094 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 877468003095 Probable transposase; Region: OrfB_IS605; pfam01385 877468003096 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 877468003097 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 877468003098 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 877468003099 intersubunit interface [polypeptide binding]; other site 877468003100 active site 877468003101 Zn2+ binding site [ion binding]; other site 877468003102 L-arabinose isomerase; Provisional; Region: PRK02929 877468003103 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 877468003104 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 877468003105 trimer interface [polypeptide binding]; other site 877468003106 putative substrate binding site [chemical binding]; other site 877468003107 putative metal binding site [ion binding]; other site 877468003108 ribulokinase; Provisional; Region: PRK04123 877468003109 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 877468003110 active site 877468003111 N- and C-terminal domain interface [polypeptide binding]; other site 877468003112 MgATP binding site [chemical binding]; other site 877468003113 carbohydrate binding site [chemical binding]; other site 877468003114 homodimer interface [polypeptide binding]; other site 877468003115 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 877468003116 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 877468003117 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 877468003118 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 877468003119 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 877468003120 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 877468003121 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 877468003122 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 877468003123 Walker A/P-loop; other site 877468003124 ATP binding site [chemical binding]; other site 877468003125 Q-loop/lid; other site 877468003126 ABC transporter signature motif; other site 877468003127 Walker B; other site 877468003128 D-loop; other site 877468003129 H-loop/switch region; other site 877468003130 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 877468003131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468003132 dimer interface [polypeptide binding]; other site 877468003133 conserved gate region; other site 877468003134 putative PBP binding loops; other site 877468003135 ABC-ATPase subunit interface; other site 877468003136 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468003137 dimer interface [polypeptide binding]; other site 877468003138 conserved gate region; other site 877468003139 putative PBP binding loops; other site 877468003140 ABC-ATPase subunit interface; other site 877468003141 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 877468003142 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 877468003143 transcriptional regulator SgrR; Provisional; Region: PRK13626 877468003144 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 877468003145 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 877468003146 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 877468003147 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 877468003148 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 877468003149 substrate binding site [chemical binding]; other site 877468003150 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 877468003151 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 877468003152 substrate binding site [chemical binding]; other site 877468003153 ligand binding site [chemical binding]; other site 877468003154 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 877468003155 tartrate dehydrogenase; Region: TTC; TIGR02089 877468003156 2-isopropylmalate synthase; Validated; Region: PRK00915 877468003157 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 877468003158 active site 877468003159 catalytic residues [active] 877468003160 metal binding site [ion binding]; metal-binding site 877468003161 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 877468003162 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 877468003163 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468003164 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 877468003165 putative substrate binding pocket [chemical binding]; other site 877468003166 putative dimerization interface [polypeptide binding]; other site 877468003167 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 877468003168 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 877468003169 PYR/PP interface [polypeptide binding]; other site 877468003170 dimer interface [polypeptide binding]; other site 877468003171 TPP binding site [chemical binding]; other site 877468003172 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 877468003173 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 877468003174 TPP-binding site [chemical binding]; other site 877468003175 dimer interface [polypeptide binding]; other site 877468003176 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 877468003177 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 877468003178 putative valine binding site [chemical binding]; other site 877468003179 dimer interface [polypeptide binding]; other site 877468003180 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 877468003181 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 877468003182 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 877468003183 DNA binding site [nucleotide binding] 877468003184 domain linker motif; other site 877468003185 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 877468003186 dimerization interface [polypeptide binding]; other site 877468003187 ligand binding site [chemical binding]; other site 877468003188 mraZ protein; Region: TIGR00242 877468003189 MraZ protein; Region: MraZ; pfam02381 877468003190 MraZ protein; Region: MraZ; pfam02381 877468003191 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 877468003192 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 877468003193 cell division protein FtsL; Provisional; Region: PRK10772 877468003194 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 877468003195 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 877468003196 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 877468003197 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 877468003198 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 877468003199 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 877468003200 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 877468003201 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 877468003202 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 877468003203 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 877468003204 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 877468003205 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 877468003206 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 877468003207 Mg++ binding site [ion binding]; other site 877468003208 putative catalytic motif [active] 877468003209 putative substrate binding site [chemical binding]; other site 877468003210 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 877468003211 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 877468003212 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 877468003213 cell division protein FtsW; Provisional; Region: PRK10774 877468003214 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 877468003215 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 877468003216 active site 877468003217 homodimer interface [polypeptide binding]; other site 877468003218 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 877468003219 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 877468003220 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 877468003221 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 877468003222 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 877468003223 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 877468003224 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 877468003225 cell division protein FtsQ; Provisional; Region: PRK10775 877468003226 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 877468003227 Cell division protein FtsQ; Region: FtsQ; pfam03799 877468003228 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 877468003229 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 877468003230 Cell division protein FtsA; Region: FtsA; pfam14450 877468003231 cell division protein FtsZ; Validated; Region: PRK09330 877468003232 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 877468003233 nucleotide binding site [chemical binding]; other site 877468003234 SulA interaction site; other site 877468003235 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 877468003236 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 877468003237 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 877468003238 SecA regulator SecM; Provisional; Region: PRK02943 877468003239 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 877468003240 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 877468003241 SEC-C motif; Region: SEC-C; pfam02810 877468003242 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 877468003243 active site 877468003244 8-oxo-dGMP binding site [chemical binding]; other site 877468003245 nudix motif; other site 877468003246 metal binding site [ion binding]; metal-binding site 877468003247 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 877468003248 DNA gyrase inhibitor; Reviewed; Region: PRK00418 877468003249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 877468003250 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 877468003251 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 877468003252 CoA-binding site [chemical binding]; other site 877468003253 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 877468003254 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 877468003255 active site 877468003256 type IV pilin biogenesis protein; Provisional; Region: PRK10573 877468003257 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 877468003258 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 877468003259 hypothetical protein; Provisional; Region: PRK10436 877468003260 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 877468003261 Walker A motif; other site 877468003262 ATP binding site [chemical binding]; other site 877468003263 Walker B motif; other site 877468003264 putative major pilin subunit; Provisional; Region: PRK10574 877468003265 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 877468003266 Pilin (bacterial filament); Region: Pilin; pfam00114 877468003267 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 877468003268 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 877468003269 dimerization interface [polypeptide binding]; other site 877468003270 active site 877468003271 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 877468003272 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 877468003273 amidase catalytic site [active] 877468003274 Zn binding residues [ion binding]; other site 877468003275 substrate binding site [chemical binding]; other site 877468003276 regulatory protein AmpE; Provisional; Region: PRK10987 877468003277 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 877468003278 active site 877468003279 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 877468003280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468003281 putative substrate translocation pore; other site 877468003282 aromatic amino acid transporter; Provisional; Region: PRK10238 877468003283 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 877468003284 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 877468003285 DNA-binding site [nucleotide binding]; DNA binding site 877468003286 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 877468003287 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 877468003288 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 877468003289 dimer interface [polypeptide binding]; other site 877468003290 TPP-binding site [chemical binding]; other site 877468003291 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 877468003292 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 877468003293 E3 interaction surface; other site 877468003294 lipoyl attachment site [posttranslational modification]; other site 877468003295 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 877468003296 E3 interaction surface; other site 877468003297 lipoyl attachment site [posttranslational modification]; other site 877468003298 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 877468003299 E3 interaction surface; other site 877468003300 lipoyl attachment site [posttranslational modification]; other site 877468003301 e3 binding domain; Region: E3_binding; pfam02817 877468003302 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 877468003303 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 877468003304 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 877468003305 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 877468003306 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 877468003307 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 877468003308 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 877468003309 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 877468003310 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 877468003311 substrate binding site [chemical binding]; other site 877468003312 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 877468003313 substrate binding site [chemical binding]; other site 877468003314 ligand binding site [chemical binding]; other site 877468003315 putative inner membrane protein; Provisional; Region: PRK09823 877468003316 Low molecular weight phosphatase family; Region: LMWPc; cl00105 877468003317 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3112 877468003318 2-keto-3-deoxygluconate permease; Provisional; Region: PRK12460 877468003319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 877468003320 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 877468003321 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 877468003322 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 877468003323 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 877468003324 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 877468003325 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 877468003326 spermidine synthase; Provisional; Region: PRK00811 877468003327 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 877468003328 S-adenosylmethionine binding site [chemical binding]; other site 877468003329 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 877468003330 multicopper oxidase; Provisional; Region: PRK10965 877468003331 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 877468003332 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 877468003333 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 877468003334 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 877468003335 Trp docking motif [polypeptide binding]; other site 877468003336 putative active site [active] 877468003337 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 877468003338 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 877468003339 active site 877468003340 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 877468003341 active site clefts [active] 877468003342 zinc binding site [ion binding]; other site 877468003343 dimer interface [polypeptide binding]; other site 877468003344 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 877468003345 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 877468003346 Walker A/P-loop; other site 877468003347 ATP binding site [chemical binding]; other site 877468003348 Q-loop/lid; other site 877468003349 ABC transporter signature motif; other site 877468003350 Walker B; other site 877468003351 D-loop; other site 877468003352 H-loop/switch region; other site 877468003353 inner membrane transport permease; Provisional; Region: PRK15066 877468003354 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 877468003355 putative fimbrial protein StiH; Provisional; Region: PRK15297 877468003356 fimbrial outer membrane usher protein StiC; Provisional; Region: PRK15298 877468003357 PapC N-terminal domain; Region: PapC_N; pfam13954 877468003358 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 877468003359 PapC C-terminal domain; Region: PapC_C; pfam13953 877468003360 fimbrial chaperone protein StiB; Provisional; Region: PRK15299 877468003361 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 877468003362 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 877468003363 fimbrial protein StiA; Provisional; Region: PRK15300 877468003364 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 877468003365 active pocket/dimerization site; other site 877468003366 active site 877468003367 phosphorylation site [posttranslational modification] 877468003368 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 877468003369 putative active site [active] 877468003370 putative metal binding site [ion binding]; other site 877468003371 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 877468003372 tetramerization interface [polypeptide binding]; other site 877468003373 active site 877468003374 Pantoate-beta-alanine ligase; Region: PanC; cd00560 877468003375 pantoate--beta-alanine ligase; Region: panC; TIGR00018 877468003376 active site 877468003377 ATP-binding site [chemical binding]; other site 877468003378 pantoate-binding site; other site 877468003379 HXXH motif; other site 877468003380 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 877468003381 oligomerization interface [polypeptide binding]; other site 877468003382 active site 877468003383 metal binding site [ion binding]; metal-binding site 877468003384 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 877468003385 catalytic center binding site [active] 877468003386 ATP binding site [chemical binding]; other site 877468003387 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 877468003388 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 877468003389 active site 877468003390 NTP binding site [chemical binding]; other site 877468003391 metal binding triad [ion binding]; metal-binding site 877468003392 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 877468003393 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 877468003394 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 877468003395 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 877468003396 active site 877468003397 nucleotide binding site [chemical binding]; other site 877468003398 HIGH motif; other site 877468003399 KMSKS motif; other site 877468003400 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 877468003401 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 877468003402 2'-5' RNA ligase; Provisional; Region: PRK15124 877468003403 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 877468003404 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 877468003405 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 877468003406 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 877468003407 ATP binding site [chemical binding]; other site 877468003408 putative Mg++ binding site [ion binding]; other site 877468003409 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 877468003410 nucleotide binding region [chemical binding]; other site 877468003411 ATP-binding site [chemical binding]; other site 877468003412 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 877468003413 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 877468003414 Transglycosylase; Region: Transgly; pfam00912 877468003415 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 877468003416 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 877468003417 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 877468003418 N-terminal plug; other site 877468003419 ligand-binding site [chemical binding]; other site 877468003420 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 877468003421 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 877468003422 Walker A/P-loop; other site 877468003423 ATP binding site [chemical binding]; other site 877468003424 Q-loop/lid; other site 877468003425 ABC transporter signature motif; other site 877468003426 Walker B; other site 877468003427 D-loop; other site 877468003428 H-loop/switch region; other site 877468003429 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 877468003430 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 877468003431 siderophore binding site; other site 877468003432 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 877468003433 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 877468003434 ABC-ATPase subunit interface; other site 877468003435 dimer interface [polypeptide binding]; other site 877468003436 putative PBP binding regions; other site 877468003437 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 877468003438 ABC-ATPase subunit interface; other site 877468003439 dimer interface [polypeptide binding]; other site 877468003440 putative PBP binding regions; other site 877468003441 putative fimbrial subunit StfA; Provisional; Region: PRK15283 877468003442 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 877468003443 PapC N-terminal domain; Region: PapC_N; pfam13954 877468003444 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 877468003445 PapC C-terminal domain; Region: PapC_C; pfam13953 877468003446 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 877468003447 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 877468003448 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 877468003449 Fimbrial protein; Region: Fimbrial; cl01416 877468003450 putative minor fimbrial subunit StfF; Provisional; Region: PRK15287 877468003451 putative minor fimbrial subunit StfG; Provisional; Region: PRK15288 877468003452 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 877468003453 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 877468003454 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 877468003455 inhibitor-cofactor binding pocket; inhibition site 877468003456 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468003457 catalytic residue [active] 877468003458 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 877468003459 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 877468003460 Cl- selectivity filter; other site 877468003461 Cl- binding residues [ion binding]; other site 877468003462 pore gating glutamate residue; other site 877468003463 dimer interface [polypeptide binding]; other site 877468003464 H+/Cl- coupling transport residue; other site 877468003465 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 877468003466 hypothetical protein; Provisional; Region: PRK10578 877468003467 UPF0126 domain; Region: UPF0126; pfam03458 877468003468 UPF0126 domain; Region: UPF0126; pfam03458 877468003469 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 877468003470 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 877468003471 cobalamin binding residues [chemical binding]; other site 877468003472 putative BtuC binding residues; other site 877468003473 dimer interface [polypeptide binding]; other site 877468003474 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 877468003475 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 877468003476 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 877468003477 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 877468003478 Zn2+ binding site [ion binding]; other site 877468003479 Mg2+ binding site [ion binding]; other site 877468003480 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 877468003481 serine endoprotease; Provisional; Region: PRK10942 877468003482 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 877468003483 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 877468003484 protein binding site [polypeptide binding]; other site 877468003485 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 877468003486 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 877468003487 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 877468003488 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 877468003489 hypothetical protein; Provisional; Region: PRK13677 877468003490 shikimate transporter; Provisional; Region: PRK09952 877468003491 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468003492 putative substrate translocation pore; other site 877468003493 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 877468003494 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 877468003495 trimer interface [polypeptide binding]; other site 877468003496 active site 877468003497 substrate binding site [chemical binding]; other site 877468003498 CoA binding site [chemical binding]; other site 877468003499 PII uridylyl-transferase; Provisional; Region: PRK05007 877468003500 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 877468003501 metal binding triad; other site 877468003502 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 877468003503 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 877468003504 Zn2+ binding site [ion binding]; other site 877468003505 Mg2+ binding site [ion binding]; other site 877468003506 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 877468003507 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 877468003508 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 877468003509 active site 877468003510 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 877468003511 rRNA interaction site [nucleotide binding]; other site 877468003512 S8 interaction site; other site 877468003513 putative laminin-1 binding site; other site 877468003514 elongation factor Ts; Provisional; Region: tsf; PRK09377 877468003515 UBA/TS-N domain; Region: UBA; pfam00627 877468003516 Elongation factor TS; Region: EF_TS; pfam00889 877468003517 Elongation factor TS; Region: EF_TS; pfam00889 877468003518 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 877468003519 putative nucleotide binding site [chemical binding]; other site 877468003520 uridine monophosphate binding site [chemical binding]; other site 877468003521 homohexameric interface [polypeptide binding]; other site 877468003522 ribosome recycling factor; Reviewed; Region: frr; PRK00083 877468003523 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 877468003524 hinge region; other site 877468003525 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 877468003526 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 877468003527 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 877468003528 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 877468003529 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 877468003530 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 877468003531 catalytic residue [active] 877468003532 putative FPP diphosphate binding site; other site 877468003533 putative FPP binding hydrophobic cleft; other site 877468003534 dimer interface [polypeptide binding]; other site 877468003535 putative IPP diphosphate binding site; other site 877468003536 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 877468003537 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 877468003538 zinc metallopeptidase RseP; Provisional; Region: PRK10779 877468003539 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 877468003540 active site 877468003541 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 877468003542 protein binding site [polypeptide binding]; other site 877468003543 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 877468003544 protein binding site [polypeptide binding]; other site 877468003545 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 877468003546 putative substrate binding region [chemical binding]; other site 877468003547 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 877468003548 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 877468003549 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 877468003550 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 877468003551 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 877468003552 Surface antigen; Region: Bac_surface_Ag; pfam01103 877468003553 periplasmic chaperone; Provisional; Region: PRK10780 877468003554 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 877468003555 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 877468003556 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 877468003557 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 877468003558 trimer interface [polypeptide binding]; other site 877468003559 active site 877468003560 UDP-GlcNAc binding site [chemical binding]; other site 877468003561 lipid binding site [chemical binding]; lipid-binding site 877468003562 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 877468003563 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 877468003564 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 877468003565 active site 877468003566 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 877468003567 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 877468003568 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 877468003569 RNA/DNA hybrid binding site [nucleotide binding]; other site 877468003570 active site 877468003571 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 877468003572 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 877468003573 putative active site [active] 877468003574 putative PHP Thumb interface [polypeptide binding]; other site 877468003575 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 877468003576 generic binding surface II; other site 877468003577 generic binding surface I; other site 877468003578 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 877468003579 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 877468003580 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 877468003581 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 877468003582 putative sugar binding site [chemical binding]; other site 877468003583 catalytic residues [active] 877468003584 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 877468003585 lysine decarboxylase LdcC; Provisional; Region: PRK15399 877468003586 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 877468003587 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 877468003588 homodimer interface [polypeptide binding]; other site 877468003589 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468003590 catalytic residue [active] 877468003591 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 877468003592 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 877468003593 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 877468003594 putative metal binding site [ion binding]; other site 877468003595 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 877468003596 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 877468003597 Ligand Binding Site [chemical binding]; other site 877468003598 TilS substrate binding domain; Region: TilS; pfam09179 877468003599 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 877468003600 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 877468003601 hypothetical protein; Provisional; Region: PRK04964 877468003602 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 877468003603 hypothetical protein; Provisional; Region: PRK09256 877468003604 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 877468003605 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 877468003606 NlpE N-terminal domain; Region: NlpE; pfam04170 877468003607 prolyl-tRNA synthetase; Provisional; Region: PRK09194 877468003608 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 877468003609 dimer interface [polypeptide binding]; other site 877468003610 motif 1; other site 877468003611 active site 877468003612 motif 2; other site 877468003613 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 877468003614 putative deacylase active site [active] 877468003615 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 877468003616 active site 877468003617 motif 3; other site 877468003618 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 877468003619 anticodon binding site; other site 877468003620 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 877468003621 homodimer interaction site [polypeptide binding]; other site 877468003622 cofactor binding site; other site 877468003623 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 877468003624 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 877468003625 lipoprotein, YaeC family; Region: TIGR00363 877468003626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468003627 dimer interface [polypeptide binding]; other site 877468003628 conserved gate region; other site 877468003629 ABC-ATPase subunit interface; other site 877468003630 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 877468003631 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 877468003632 Walker A/P-loop; other site 877468003633 ATP binding site [chemical binding]; other site 877468003634 Q-loop/lid; other site 877468003635 ABC transporter signature motif; other site 877468003636 Walker B; other site 877468003637 D-loop; other site 877468003638 H-loop/switch region; other site 877468003639 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 877468003640 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 877468003641 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 877468003642 active site 877468003643 motif I; other site 877468003644 motif II; other site 877468003645 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 877468003646 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 877468003647 active site 877468003648 catalytic tetrad [active] 877468003649 Transcriptional regulator [Transcription]; Region: LysR; COG0583 877468003650 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468003651 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 877468003652 putative effector binding pocket; other site 877468003653 dimerization interface [polypeptide binding]; other site 877468003654 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 877468003655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468003656 putative substrate translocation pore; other site 877468003657 hypothetical protein; Provisional; Region: PRK05421 877468003658 putative catalytic site [active] 877468003659 putative metal binding site [ion binding]; other site 877468003660 putative phosphate binding site [ion binding]; other site 877468003661 putative catalytic site [active] 877468003662 putative phosphate binding site [ion binding]; other site 877468003663 putative metal binding site [ion binding]; other site 877468003664 Methyltransferase domain; Region: Methyltransf_23; pfam13489 877468003665 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 877468003666 S-adenosylmethionine binding site [chemical binding]; other site 877468003667 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 877468003668 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 877468003669 N-acetyl-D-glucosamine binding site [chemical binding]; other site 877468003670 catalytic residue [active] 877468003671 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 877468003672 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 877468003673 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 877468003674 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 877468003675 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 877468003676 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 877468003677 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 877468003678 RNA/DNA hybrid binding site [nucleotide binding]; other site 877468003679 active site 877468003680 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 877468003681 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 877468003682 active site 877468003683 catalytic site [active] 877468003684 substrate binding site [chemical binding]; other site 877468003685 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 877468003686 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 877468003687 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 877468003688 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 877468003689 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 877468003690 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 877468003691 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 877468003692 ImpE protein; Region: ImpE; pfam07024 877468003693 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 877468003694 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 877468003695 Walker A motif; other site 877468003696 ATP binding site [chemical binding]; other site 877468003697 Walker B motif; other site 877468003698 arginine finger; other site 877468003699 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 877468003700 Walker A motif; other site 877468003701 ATP binding site [chemical binding]; other site 877468003702 Walker B motif; other site 877468003703 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 877468003704 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 877468003705 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 877468003706 Protein of unknown function (DUF877); Region: DUF877; pfam05943 877468003707 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 877468003708 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 877468003709 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 877468003710 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 877468003711 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 877468003712 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 877468003713 hypothetical protein; Provisional; Region: PRK08126 877468003714 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 877468003715 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 877468003716 ligand binding site [chemical binding]; other site 877468003717 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 877468003718 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 877468003719 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 877468003720 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 877468003721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4893 877468003722 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 877468003723 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 877468003724 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 877468003725 Uncharacterized conserved protein [Function unknown]; Region: COG5435 877468003726 PAAR motif; Region: PAAR_motif; pfam05488 877468003727 RHS Repeat; Region: RHS_repeat; pfam05593 877468003728 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 877468003729 RHS Repeat; Region: RHS_repeat; pfam05593 877468003730 RHS Repeat; Region: RHS_repeat; pfam05593 877468003731 RHS protein; Region: RHS; pfam03527 877468003732 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 877468003733 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 877468003734 Protein of unknown function (DUF4019); Region: DUF4019; pfam13211 877468003735 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 877468003736 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 877468003737 Integrase core domain; Region: rve_3; pfam13683 877468003738 pili assembly chaperone protein SafB; Provisional; Region: PRK15224 877468003739 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 877468003740 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 877468003741 pilin outer membrane usher protein SafC; Provisional; Region: PRK15223 877468003742 PapC N-terminal domain; Region: PapC_N; pfam13954 877468003743 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 877468003744 PapC C-terminal domain; Region: PapC_C; pfam13953 877468003745 Enterobacteria AfaD invasin protein; Region: AfaD; cl05376 877468003746 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 877468003747 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 877468003748 putative active site [active] 877468003749 putative metal binding site [ion binding]; other site 877468003750 Transcriptional regulator [Transcription]; Region: LysR; COG0583 877468003751 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468003752 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 877468003753 dimerization interface [polypeptide binding]; other site 877468003754 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 877468003755 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 877468003756 dimer interface [polypeptide binding]; other site 877468003757 C-N hydrolase family amidase; Provisional; Region: PRK10438 877468003758 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 877468003759 putative active site [active] 877468003760 catalytic triad [active] 877468003761 dimer interface [polypeptide binding]; other site 877468003762 multimer interface [polypeptide binding]; other site 877468003763 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 877468003764 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 877468003765 active site 877468003766 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 877468003767 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 877468003768 dimer interface [polypeptide binding]; other site 877468003769 active site 877468003770 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 877468003771 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 877468003772 putative active site [active] 877468003773 putative dimer interface [polypeptide binding]; other site 877468003774 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 877468003775 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 877468003776 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 877468003777 active site 877468003778 DNA polymerase IV; Validated; Region: PRK02406 877468003779 DNA binding site [nucleotide binding] 877468003780 hypothetical protein; Reviewed; Region: PRK09588 877468003781 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 877468003782 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 877468003783 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 877468003784 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 877468003785 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 877468003786 metal binding site [ion binding]; metal-binding site 877468003787 dimer interface [polypeptide binding]; other site 877468003788 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 877468003789 active site 877468003790 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 877468003791 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 877468003792 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 877468003793 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 877468003794 trimer interface [polypeptide binding]; other site 877468003795 eyelet of channel; other site 877468003796 gamma-glutamyl kinase; Provisional; Region: PRK05429 877468003797 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 877468003798 nucleotide binding site [chemical binding]; other site 877468003799 homotetrameric interface [polypeptide binding]; other site 877468003800 putative phosphate binding site [ion binding]; other site 877468003801 putative allosteric binding site; other site 877468003802 PUA domain; Region: PUA; pfam01472 877468003803 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 877468003804 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 877468003805 putative catalytic cysteine [active] 877468003806 Integrase core domain; Region: rve; pfam00665 877468003807 Integrase core domain; Region: rve_2; pfam13333 877468003808 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 877468003809 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 877468003810 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 877468003811 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 877468003812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468003813 putative substrate translocation pore; other site 877468003814 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 877468003815 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 877468003816 substrate binding site [chemical binding]; other site 877468003817 ligand binding site [chemical binding]; other site 877468003818 3-isopropylmalate dehydratase small subunit [Amino acid transport and metabolism]; Region: LeuD; COG0066 877468003819 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 877468003820 hypothetical protein; Provisional; Region: PRK14812 877468003821 substrate binding site [chemical binding]; other site 877468003822 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 877468003823 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 877468003824 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 877468003825 transcriptional activator TtdR; Provisional; Region: PRK09801 877468003826 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468003827 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 877468003828 putative effector binding pocket; other site 877468003829 putative dimerization interface [polypeptide binding]; other site 877468003830 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 877468003831 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 877468003832 putative fimbrial usher protein StbD; Provisional; Region: PRK15247 877468003833 fimbrial outer membrane usher protein StbC; Provisional; Region: PRK15248 877468003834 PapC N-terminal domain; Region: PapC_N; pfam13954 877468003835 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 877468003836 PapC C-terminal domain; Region: PapC_C; pfam13953 877468003837 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 877468003838 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 877468003839 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 877468003840 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 877468003841 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 877468003842 DNA binding site [nucleotide binding] 877468003843 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 877468003844 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 877468003845 DNA binding residues [nucleotide binding] 877468003846 dimerization interface [polypeptide binding]; other site 877468003847 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 877468003848 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 877468003849 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 877468003850 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 877468003851 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 877468003852 HlyD family secretion protein; Region: HlyD_3; pfam13437 877468003853 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 877468003854 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 877468003855 metal-binding site [ion binding] 877468003856 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 877468003857 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 877468003858 motif II; other site 877468003859 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 877468003860 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 877468003861 DNA binding residues [nucleotide binding] 877468003862 dimer interface [polypeptide binding]; other site 877468003863 copper binding site [ion binding]; other site 877468003864 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 877468003865 metal-binding site [ion binding] 877468003866 putative sialic acid transporter; Region: 2A0112; TIGR00891 877468003867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468003868 putative substrate translocation pore; other site 877468003869 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 877468003870 DNA methylase; Region: N6_N4_Mtase; cl17433 877468003871 DNA methylase; Region: N6_N4_Mtase; pfam01555 877468003872 type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483 877468003873 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 877468003874 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 877468003875 VRR-NUC domain; Region: VRR_NUC; pfam08774 877468003876 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 877468003877 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 877468003878 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 877468003879 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 877468003880 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 877468003881 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 877468003882 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 877468003883 N-terminal plug; other site 877468003884 ligand-binding site [chemical binding]; other site 877468003885 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 877468003886 hypothetical protein; Provisional; Region: PRK09929 877468003887 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 877468003888 Propionate catabolism activator; Region: PrpR_N; pfam06506 877468003889 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 877468003890 Walker A motif; other site 877468003891 ATP binding site [chemical binding]; other site 877468003892 Walker B motif; other site 877468003893 arginine finger; other site 877468003894 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 877468003895 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 877468003896 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 877468003897 tetramer interface [polypeptide binding]; other site 877468003898 active site 877468003899 Mg2+/Mn2+ binding site [ion binding]; other site 877468003900 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 877468003901 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 877468003902 dimer interface [polypeptide binding]; other site 877468003903 active site 877468003904 citrylCoA binding site [chemical binding]; other site 877468003905 oxalacetate/citrate binding site [chemical binding]; other site 877468003906 coenzyme A binding site [chemical binding]; other site 877468003907 catalytic triad [active] 877468003908 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 877468003909 2-methylcitrate dehydratase; Region: prpD; TIGR02330 877468003910 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 877468003911 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 877468003912 acyl-activating enzyme (AAE) consensus motif; other site 877468003913 AMP binding site [chemical binding]; other site 877468003914 active site 877468003915 CoA binding site [chemical binding]; other site 877468003916 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 877468003917 dimer interface [polypeptide binding]; other site 877468003918 active site 877468003919 Schiff base residues; other site 877468003920 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 877468003921 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 877468003922 Autotransporter beta-domain; Region: Autotransporter; pfam03797 877468003923 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 877468003924 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 877468003925 ligand binding site [chemical binding]; other site 877468003926 flexible hinge region; other site 877468003927 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 877468003928 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 877468003929 microcin B17 transporter; Reviewed; Region: PRK11098 877468003930 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 877468003931 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 877468003932 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 877468003933 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 877468003934 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 877468003935 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 877468003936 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 877468003937 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 877468003938 drug efflux system protein MdtG; Provisional; Region: PRK09874 877468003939 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468003940 putative substrate translocation pore; other site 877468003941 anti-RssB factor; Provisional; Region: PRK10244 877468003942 hypothetical protein; Provisional; Region: PRK11505 877468003943 psiF repeat; Region: PsiF_repeat; pfam07769 877468003944 psiF repeat; Region: PsiF_repeat; pfam07769 877468003945 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 877468003946 MASE2 domain; Region: MASE2; pfam05230 877468003947 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 877468003948 metal binding site [ion binding]; metal-binding site 877468003949 active site 877468003950 I-site; other site 877468003951 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 877468003952 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 877468003953 hypothetical protein; Validated; Region: PRK00124 877468003954 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 877468003955 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 877468003956 ADP binding site [chemical binding]; other site 877468003957 magnesium binding site [ion binding]; other site 877468003958 putative shikimate binding site; other site 877468003959 hypothetical protein; Provisional; Region: PRK10380 877468003960 hypothetical protein; Provisional; Region: PRK10481 877468003961 hypothetical protein; Provisional; Region: PRK10579 877468003962 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 877468003963 fructokinase; Reviewed; Region: PRK09557 877468003964 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 877468003965 nucleotide binding site [chemical binding]; other site 877468003966 MFS transport protein AraJ; Provisional; Region: PRK10091 877468003967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468003968 putative substrate translocation pore; other site 877468003969 exonuclease subunit SbcC; Provisional; Region: PRK10246 877468003970 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 877468003971 Walker A/P-loop; other site 877468003972 ATP binding site [chemical binding]; other site 877468003973 Q-loop/lid; other site 877468003974 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 877468003975 ABC transporter signature motif; other site 877468003976 Walker B; other site 877468003977 D-loop; other site 877468003978 H-loop/switch region; other site 877468003979 exonuclease subunit SbcD; Provisional; Region: PRK10966 877468003980 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 877468003981 active site 877468003982 metal binding site [ion binding]; metal-binding site 877468003983 DNA binding site [nucleotide binding] 877468003984 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 877468003985 transcriptional regulator PhoB; Provisional; Region: PRK10161 877468003986 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 877468003987 active site 877468003988 phosphorylation site [posttranslational modification] 877468003989 intermolecular recognition site; other site 877468003990 dimerization interface [polypeptide binding]; other site 877468003991 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 877468003992 DNA binding site [nucleotide binding] 877468003993 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 877468003994 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 877468003995 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 877468003996 putative active site [active] 877468003997 heme pocket [chemical binding]; other site 877468003998 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 877468003999 dimer interface [polypeptide binding]; other site 877468004000 phosphorylation site [posttranslational modification] 877468004001 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 877468004002 ATP binding site [chemical binding]; other site 877468004003 Mg2+ binding site [ion binding]; other site 877468004004 G-X-G motif; other site 877468004005 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 877468004006 putative proline-specific permease; Provisional; Region: proY; PRK10580 877468004007 maltodextrin glucosidase; Provisional; Region: PRK10785 877468004008 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 877468004009 homodimer interface [polypeptide binding]; other site 877468004010 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 877468004011 active site 877468004012 homodimer interface [polypeptide binding]; other site 877468004013 catalytic site [active] 877468004014 peroxidase; Provisional; Region: PRK15000 877468004015 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 877468004016 dimer interface [polypeptide binding]; other site 877468004017 decamer (pentamer of dimers) interface [polypeptide binding]; other site 877468004018 catalytic triad [active] 877468004019 peroxidatic and resolving cysteines [active] 877468004020 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 877468004021 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 877468004022 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 877468004023 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 877468004024 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 877468004025 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 877468004026 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 877468004027 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 877468004028 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 877468004029 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 877468004030 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 877468004031 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 877468004032 Protein export membrane protein; Region: SecD_SecF; pfam02355 877468004033 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 877468004034 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 877468004035 Predicted transcriptional regulator [Transcription]; Region: COG2378 877468004036 HTH domain; Region: HTH_11; pfam08279 877468004037 WYL domain; Region: WYL; pfam13280 877468004038 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 877468004039 active site 877468004040 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 877468004041 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 877468004042 hypothetical protein; Provisional; Region: PRK11530 877468004043 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 877468004044 ATP cone domain; Region: ATP-cone; pfam03477 877468004045 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 877468004046 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 877468004047 catalytic motif [active] 877468004048 Zn binding site [ion binding]; other site 877468004049 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 877468004050 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 877468004051 homopentamer interface [polypeptide binding]; other site 877468004052 active site 877468004053 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 877468004054 putative RNA binding site [nucleotide binding]; other site 877468004055 thiamine monophosphate kinase; Provisional; Region: PRK05731 877468004056 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 877468004057 ATP binding site [chemical binding]; other site 877468004058 dimerization interface [polypeptide binding]; other site 877468004059 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 877468004060 tetramer interfaces [polypeptide binding]; other site 877468004061 binuclear metal-binding site [ion binding]; other site 877468004062 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 877468004063 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 877468004064 active site 877468004065 catalytic tetrad [active] 877468004066 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 877468004067 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 877468004068 TPP-binding site; other site 877468004069 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 877468004070 PYR/PP interface [polypeptide binding]; other site 877468004071 dimer interface [polypeptide binding]; other site 877468004072 TPP binding site [chemical binding]; other site 877468004073 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 877468004074 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 877468004075 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 877468004076 substrate binding pocket [chemical binding]; other site 877468004077 chain length determination region; other site 877468004078 substrate-Mg2+ binding site; other site 877468004079 catalytic residues [active] 877468004080 aspartate-rich region 1; other site 877468004081 active site lid residues [active] 877468004082 aspartate-rich region 2; other site 877468004083 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 877468004084 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 877468004085 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 877468004086 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 877468004087 Ligand Binding Site [chemical binding]; other site 877468004088 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 877468004089 active site residue [active] 877468004090 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 877468004091 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468004092 dimer interface [polypeptide binding]; other site 877468004093 conserved gate region; other site 877468004094 putative PBP binding loops; other site 877468004095 ABC-ATPase subunit interface; other site 877468004096 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 877468004097 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468004098 dimer interface [polypeptide binding]; other site 877468004099 conserved gate region; other site 877468004100 putative PBP binding loops; other site 877468004101 ABC-ATPase subunit interface; other site 877468004102 2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258 877468004103 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 877468004104 Walker A/P-loop; other site 877468004105 ATP binding site [chemical binding]; other site 877468004106 Q-loop/lid; other site 877468004107 ABC transporter signature motif; other site 877468004108 Walker B; other site 877468004109 D-loop; other site 877468004110 H-loop/switch region; other site 877468004111 TOBE domain; Region: TOBE_2; pfam08402 877468004112 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 877468004113 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 877468004114 transcriptional regulator protein; Region: phnR; TIGR03337 877468004115 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 877468004116 DNA-binding site [nucleotide binding]; DNA binding site 877468004117 UTRA domain; Region: UTRA; pfam07702 877468004118 2-aminoethylphosphonate--pyruvate transaminase; Region: transamin_PhnW; TIGR02326 877468004119 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 877468004120 catalytic residue [active] 877468004121 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 877468004122 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 877468004123 motif II; other site 877468004124 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 877468004125 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 877468004126 conserved cys residue [active] 877468004127 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 877468004128 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 877468004129 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 877468004130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 877468004131 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 877468004132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468004133 Major Facilitator Superfamily; Region: MFS_1; pfam07690 877468004134 putative substrate translocation pore; other site 877468004135 Sel1-like repeats; Region: SEL1; smart00671 877468004136 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 877468004137 Sel1 repeat; Region: Sel1; pfam08238 877468004138 Sel1-like repeats; Region: SEL1; smart00671 877468004139 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 877468004140 Sel1-like repeats; Region: SEL1; smart00671 877468004141 Sel1-like repeats; Region: SEL1; smart00671 877468004142 Sel1-like repeats; Region: SEL1; smart00671 877468004143 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 877468004144 UbiA prenyltransferase family; Region: UbiA; pfam01040 877468004145 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 877468004146 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 877468004147 Subunit III/IV interface [polypeptide binding]; other site 877468004148 Subunit I/III interface [polypeptide binding]; other site 877468004149 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 877468004150 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 877468004151 D-pathway; other site 877468004152 Putative ubiquinol binding site [chemical binding]; other site 877468004153 Low-spin heme (heme b) binding site [chemical binding]; other site 877468004154 Putative water exit pathway; other site 877468004155 Binuclear center (heme o3/CuB) [ion binding]; other site 877468004156 K-pathway; other site 877468004157 Putative proton exit pathway; other site 877468004158 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 877468004159 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 877468004160 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 877468004161 muropeptide transporter; Reviewed; Region: ampG; PRK11902 877468004162 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468004163 putative substrate translocation pore; other site 877468004164 hypothetical protein; Provisional; Region: PRK11627 877468004165 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 877468004166 transcriptional regulator BolA; Provisional; Region: PRK11628 877468004167 trigger factor; Provisional; Region: tig; PRK01490 877468004168 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 877468004169 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 877468004170 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 877468004171 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 877468004172 oligomer interface [polypeptide binding]; other site 877468004173 active site residues [active] 877468004174 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 877468004175 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 877468004176 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 877468004177 Walker A motif; other site 877468004178 ATP binding site [chemical binding]; other site 877468004179 Walker B motif; other site 877468004180 Iron permease FTR1 family; Region: FTR1; cl00475 877468004181 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 877468004182 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 877468004183 Found in ATP-dependent protease La (LON); Region: LON; smart00464 877468004184 Found in ATP-dependent protease La (LON); Region: LON; smart00464 877468004185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 877468004186 Walker A motif; other site 877468004187 ATP binding site [chemical binding]; other site 877468004188 Walker B motif; other site 877468004189 arginine finger; other site 877468004190 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 877468004191 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 877468004192 IHF dimer interface [polypeptide binding]; other site 877468004193 IHF - DNA interface [nucleotide binding]; other site 877468004194 periplasmic folding chaperone; Provisional; Region: PRK10788 877468004195 SurA N-terminal domain; Region: SurA_N_3; cl07813 877468004196 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 877468004197 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 877468004198 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 877468004199 active site 877468004200 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 877468004201 Ligand Binding Site [chemical binding]; other site 877468004202 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 877468004203 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 877468004204 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 877468004205 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 877468004206 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 877468004207 active site 877468004208 motif I; other site 877468004209 motif II; other site 877468004210 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 877468004211 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 877468004212 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 877468004213 catalytic residue [active] 877468004214 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 877468004215 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 877468004216 putative DNA binding site [nucleotide binding]; other site 877468004217 putative Zn2+ binding site [ion binding]; other site 877468004218 AsnC family; Region: AsnC_trans_reg; pfam01037 877468004219 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 877468004220 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 877468004221 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 877468004222 Walker A/P-loop; other site 877468004223 ATP binding site [chemical binding]; other site 877468004224 Q-loop/lid; other site 877468004225 ABC transporter signature motif; other site 877468004226 Walker B; other site 877468004227 D-loop; other site 877468004228 H-loop/switch region; other site 877468004229 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 877468004230 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 877468004231 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 877468004232 Walker A/P-loop; other site 877468004233 ATP binding site [chemical binding]; other site 877468004234 Q-loop/lid; other site 877468004235 ABC transporter signature motif; other site 877468004236 Walker B; other site 877468004237 D-loop; other site 877468004238 H-loop/switch region; other site 877468004239 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 877468004240 Nitrogen regulatory protein P-II; Region: P-II; smart00938 877468004241 ammonium transporter; Provisional; Region: PRK10666 877468004242 acyl-CoA thioesterase II; Provisional; Region: PRK10526 877468004243 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 877468004244 active site 877468004245 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 877468004246 catalytic triad [active] 877468004247 dimer interface [polypeptide binding]; other site 877468004248 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 877468004249 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 877468004250 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 877468004251 DNA binding site [nucleotide binding] 877468004252 active site 877468004253 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 877468004254 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 877468004255 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 877468004256 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 877468004257 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 877468004258 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 877468004259 maltose O-acetyltransferase; Provisional; Region: PRK10092 877468004260 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 877468004261 active site 877468004262 substrate binding site [chemical binding]; other site 877468004263 trimer interface [polypeptide binding]; other site 877468004264 CoA binding site [chemical binding]; other site 877468004265 gene expression modulator; Provisional; Region: PRK10945 877468004266 Hha toxicity attenuator; Provisional; Region: PRK10667 877468004267 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 877468004268 Protein export membrane protein; Region: SecD_SecF; cl14618 877468004269 Protein export membrane protein; Region: SecD_SecF; cl14618 877468004270 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 877468004271 HlyD family secretion protein; Region: HlyD_3; pfam13437 877468004272 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 877468004273 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 877468004274 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 877468004275 hypothetical protein; Provisional; Region: PRK11281 877468004276 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 877468004277 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 877468004278 Mechanosensitive ion channel; Region: MS_channel; pfam00924 877468004279 Uncharacterized conserved protein [Function unknown]; Region: COG5464 877468004280 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 877468004281 hypothetical protein; Provisional; Region: PRK11038 877468004282 primosomal replication protein N''; Provisional; Region: PRK10093 877468004283 hypothetical protein; Provisional; Region: PRK10527 877468004284 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 877468004285 active site 877468004286 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 877468004287 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 877468004288 Walker A motif; other site 877468004289 ATP binding site [chemical binding]; other site 877468004290 Walker B motif; other site 877468004291 DNA polymerase III subunit delta'; Validated; Region: PRK08485 877468004292 arginine finger; other site 877468004293 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 877468004294 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 877468004295 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 877468004296 hypothetical protein; Validated; Region: PRK00153 877468004297 recombination protein RecR; Reviewed; Region: recR; PRK00076 877468004298 RecR protein; Region: RecR; pfam02132 877468004299 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 877468004300 putative active site [active] 877468004301 putative metal-binding site [ion binding]; other site 877468004302 tetramer interface [polypeptide binding]; other site 877468004303 heat shock protein 90; Provisional; Region: PRK05218 877468004304 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 877468004305 ATP binding site [chemical binding]; other site 877468004306 Mg2+ binding site [ion binding]; other site 877468004307 G-X-G motif; other site 877468004308 adenylate kinase; Reviewed; Region: adk; PRK00279 877468004309 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 877468004310 AMP-binding site [chemical binding]; other site 877468004311 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 877468004312 ferrochelatase; Reviewed; Region: hemH; PRK00035 877468004313 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 877468004314 C-terminal domain interface [polypeptide binding]; other site 877468004315 active site 877468004316 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 877468004317 active site 877468004318 N-terminal domain interface [polypeptide binding]; other site 877468004319 acetyl esterase; Provisional; Region: PRK10162 877468004320 inosine/guanosine kinase; Provisional; Region: PRK15074 877468004321 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 877468004322 putative cation:proton antiport protein; Provisional; Region: PRK10669 877468004323 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 877468004324 TrkA-N domain; Region: TrkA_N; pfam02254 877468004325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468004326 Major Facilitator Superfamily; Region: MFS_1; pfam07690 877468004327 putative substrate translocation pore; other site 877468004328 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 877468004329 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 877468004330 active site 877468004331 metal binding site [ion binding]; metal-binding site 877468004332 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 877468004333 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 877468004334 putative deacylase active site [active] 877468004335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 877468004336 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 877468004337 copper exporting ATPase; Provisional; Region: copA; PRK10671 877468004338 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 877468004339 metal-binding site [ion binding] 877468004340 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 877468004341 metal-binding site [ion binding] 877468004342 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 877468004343 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 877468004344 motif II; other site 877468004345 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 877468004346 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 877468004347 DNA binding residues [nucleotide binding] 877468004348 dimer interface [polypeptide binding]; other site 877468004349 copper binding site [ion binding]; other site 877468004350 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 877468004351 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 877468004352 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 877468004353 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 877468004354 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 877468004355 Walker A/P-loop; other site 877468004356 ATP binding site [chemical binding]; other site 877468004357 Q-loop/lid; other site 877468004358 ABC transporter signature motif; other site 877468004359 Walker B; other site 877468004360 D-loop; other site 877468004361 H-loop/switch region; other site 877468004362 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 877468004363 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 877468004364 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 877468004365 oxidoreductase; Provisional; Region: PRK08017 877468004366 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 877468004367 NADP binding site [chemical binding]; other site 877468004368 active site 877468004369 steroid binding site; other site 877468004370 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 877468004371 active site 877468004372 catalytic triad [active] 877468004373 oxyanion hole [active] 877468004374 switch loop; other site 877468004375 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 877468004376 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 877468004377 Walker A/P-loop; other site 877468004378 ATP binding site [chemical binding]; other site 877468004379 Q-loop/lid; other site 877468004380 ABC transporter signature motif; other site 877468004381 Walker B; other site 877468004382 D-loop; other site 877468004383 H-loop/switch region; other site 877468004384 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 877468004385 FtsX-like permease family; Region: FtsX; pfam02687 877468004386 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 877468004387 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 877468004388 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 877468004389 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 877468004390 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 877468004391 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 877468004392 Walker A/P-loop; other site 877468004393 ATP binding site [chemical binding]; other site 877468004394 Q-loop/lid; other site 877468004395 ABC transporter signature motif; other site 877468004396 Walker B; other site 877468004397 D-loop; other site 877468004398 H-loop/switch region; other site 877468004399 NIL domain; Region: NIL; pfam09383 877468004400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468004401 dimer interface [polypeptide binding]; other site 877468004402 conserved gate region; other site 877468004403 ABC-ATPase subunit interface; other site 877468004404 Predicted ATPase [General function prediction only]; Region: COG2603 877468004405 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 877468004406 active site residue [active] 877468004407 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 877468004408 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468004409 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 877468004410 dimerization interface [polypeptide binding]; other site 877468004411 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 877468004412 ureidoglycolate hydrolase; Provisional; Region: PRK03606 877468004413 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 877468004414 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 877468004415 Bacterial transcriptional regulator; Region: IclR; pfam01614 877468004416 glyoxylate carboligase; Provisional; Region: PRK11269 877468004417 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 877468004418 PYR/PP interface [polypeptide binding]; other site 877468004419 dimer interface [polypeptide binding]; other site 877468004420 TPP binding site [chemical binding]; other site 877468004421 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 877468004422 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 877468004423 TPP-binding site [chemical binding]; other site 877468004424 hydroxypyruvate isomerase; Provisional; Region: PRK09997 877468004425 tartronate semialdehyde reductase; Provisional; Region: PRK15059 877468004426 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 877468004427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468004428 Major Facilitator Superfamily; Region: MFS_1; pfam07690 877468004429 putative substrate translocation pore; other site 877468004430 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 877468004431 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 877468004432 Na binding site [ion binding]; other site 877468004433 putative substrate binding site [chemical binding]; other site 877468004434 allantoinase; Provisional; Region: PRK08044 877468004435 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 877468004436 active site 877468004437 putative uracil/xanthine transporter; Provisional; Region: PRK11412 877468004438 glycerate kinase II; Provisional; Region: PRK09932 877468004439 Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257 877468004440 Mif2/CENP-C like; Region: Mif2; pfam11699 877468004441 Cupin domain; Region: Cupin_2; pfam07883 877468004442 allantoate amidohydrolase; Region: AllC; TIGR03176 877468004443 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 877468004444 active site 877468004445 metal binding site [ion binding]; metal-binding site 877468004446 dimer interface [polypeptide binding]; other site 877468004447 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 877468004448 membrane protein FdrA; Validated; Region: PRK06091 877468004449 CoA binding domain; Region: CoA_binding; pfam02629 877468004450 CoA-ligase; Region: Ligase_CoA; pfam00549 877468004451 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 877468004452 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 877468004453 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 877468004454 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 877468004455 putative substrate binding site [chemical binding]; other site 877468004456 nucleotide binding site [chemical binding]; other site 877468004457 nucleotide binding site [chemical binding]; other site 877468004458 homodimer interface [polypeptide binding]; other site 877468004459 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 877468004460 ATP-grasp domain; Region: ATP-grasp; pfam02222 877468004461 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 877468004462 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 877468004463 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 877468004464 putative active site [active] 877468004465 putative metal binding site [ion binding]; other site 877468004466 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 877468004467 substrate binding site [chemical binding]; other site 877468004468 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 877468004469 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 877468004470 active site 877468004471 HIGH motif; other site 877468004472 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 877468004473 KMSKS motif; other site 877468004474 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 877468004475 tRNA binding surface [nucleotide binding]; other site 877468004476 anticodon binding site; other site 877468004477 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4727 877468004478 Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916 877468004479 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 877468004480 ribosome-associated protein; Provisional; Region: PRK11507 877468004481 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 877468004482 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 877468004483 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 877468004484 homodimer interface [polypeptide binding]; other site 877468004485 NADP binding site [chemical binding]; other site 877468004486 substrate binding site [chemical binding]; other site 877468004487 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 877468004488 fimbrial protein FimI; Provisional; Region: PRK15200 877468004489 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 877468004490 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 877468004491 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 877468004492 outer membrane usher protein FimD; Provisional; Region: PRK15198 877468004493 PapC N-terminal domain; Region: PapC_N; pfam13954 877468004494 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 877468004495 PapC C-terminal domain; Region: PapC_C; pfam13953 877468004496 fimbrial-like adhesin; Provisional; Region: fimH; PRK15199 877468004497 fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934 877468004498 transcriptional regulator FimZ; Provisional; Region: PRK09935 877468004499 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 877468004500 active site 877468004501 phosphorylation site [posttranslational modification] 877468004502 intermolecular recognition site; other site 877468004503 dimerization interface [polypeptide binding]; other site 877468004504 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 877468004505 DNA binding residues [nucleotide binding] 877468004506 dimerization interface [polypeptide binding]; other site 877468004507 fimbriae regulatory protein FimW; Provisional; Region: PRK15201 877468004508 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 877468004509 DNA binding residues [nucleotide binding] 877468004510 dimerization interface [polypeptide binding]; other site 877468004511 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 877468004512 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 877468004513 Ligand binding site; other site 877468004514 Putative Catalytic site; other site 877468004515 DXD motif; other site 877468004516 Predicted membrane protein [Function unknown]; Region: COG2246 877468004517 GtrA-like protein; Region: GtrA; pfam04138 877468004518 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 877468004519 ATP binding site [chemical binding]; other site 877468004520 Mg2+ binding site [ion binding]; other site 877468004521 G-X-G motif; other site 877468004522 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 877468004523 Cupin; Region: Cupin_6; pfam12852 877468004524 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 877468004525 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 877468004526 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 877468004527 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 877468004528 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 877468004529 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 877468004530 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 877468004531 Predicted membrane protein [Function unknown]; Region: COG3059 877468004532 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 877468004533 phenylalanine transporter; Provisional; Region: PRK10249 877468004534 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 877468004535 Mechanosensitive ion channel; Region: MS_channel; pfam00924 877468004536 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 877468004537 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 877468004538 active site 877468004539 oxyanion hole [active] 877468004540 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 877468004541 catalytic triad [active] 877468004542 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 877468004543 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 877468004544 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 877468004545 ATP binding site [chemical binding]; other site 877468004546 Walker B motif; other site 877468004547 arginine finger; other site 877468004548 Transcriptional antiterminator [Transcription]; Region: COG3933 877468004549 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 877468004550 active pocket/dimerization site; other site 877468004551 active site 877468004552 phosphorylation site [posttranslational modification] 877468004553 PRD domain; Region: PRD; pfam00874 877468004554 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 877468004555 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 877468004556 putative active site [active] 877468004557 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 877468004558 dimer interface [polypeptide binding]; other site 877468004559 active site 877468004560 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 877468004561 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 877468004562 dimer interface [polypeptide binding]; other site 877468004563 active site 877468004564 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 877468004565 dimer interface [polypeptide binding]; other site 877468004566 active site 877468004567 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 877468004568 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 877468004569 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 877468004570 active site 877468004571 phosphorylation site [posttranslational modification] 877468004572 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 877468004573 active pocket/dimerization site; other site 877468004574 active site 877468004575 phosphorylation site [posttranslational modification] 877468004576 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 877468004577 dimer interface [polypeptide binding]; other site 877468004578 FMN binding site [chemical binding]; other site 877468004579 hypothetical protein; Provisional; Region: PRK10250 877468004580 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 877468004581 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 877468004582 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 877468004583 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 877468004584 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 877468004585 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 877468004586 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 877468004587 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 877468004588 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 877468004589 outer membrane receptor FepA; Provisional; Region: PRK13524 877468004590 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 877468004591 N-terminal plug; other site 877468004592 ligand-binding site [chemical binding]; other site 877468004593 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 877468004594 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 877468004595 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 877468004596 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 877468004597 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 877468004598 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 877468004599 acyl-activating enzyme (AAE) consensus motif; other site 877468004600 AMP binding site [chemical binding]; other site 877468004601 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 877468004602 LPS O-antigen length regulator; Provisional; Region: PRK10381 877468004603 Chain length determinant protein; Region: Wzz; pfam02706 877468004604 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 877468004605 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 877468004606 Walker A/P-loop; other site 877468004607 ATP binding site [chemical binding]; other site 877468004608 Q-loop/lid; other site 877468004609 ABC transporter signature motif; other site 877468004610 Walker B; other site 877468004611 D-loop; other site 877468004612 H-loop/switch region; other site 877468004613 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 877468004614 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 877468004615 ABC-ATPase subunit interface; other site 877468004616 dimer interface [polypeptide binding]; other site 877468004617 putative PBP binding regions; other site 877468004618 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 877468004619 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 877468004620 ABC-ATPase subunit interface; other site 877468004621 dimer interface [polypeptide binding]; other site 877468004622 putative PBP binding regions; other site 877468004623 enterobactin exporter EntS; Provisional; Region: PRK10489 877468004624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468004625 putative substrate translocation pore; other site 877468004626 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 877468004627 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 877468004628 siderophore binding site; other site 877468004629 isochorismate synthase EntC; Provisional; Region: PRK15016 877468004630 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 877468004631 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 877468004632 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 877468004633 acyl-activating enzyme (AAE) consensus motif; other site 877468004634 active site 877468004635 AMP binding site [chemical binding]; other site 877468004636 substrate binding site [chemical binding]; other site 877468004637 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 877468004638 hydrophobic substrate binding pocket; other site 877468004639 Isochorismatase family; Region: Isochorismatase; pfam00857 877468004640 active site 877468004641 conserved cis-peptide bond; other site 877468004642 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 877468004643 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 877468004644 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 877468004645 putative NAD(P) binding site [chemical binding]; other site 877468004646 active site 877468004647 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 877468004648 CoenzymeA binding site [chemical binding]; other site 877468004649 subunit interaction site [polypeptide binding]; other site 877468004650 PHB binding site; other site 877468004651 carbon starvation protein A; Provisional; Region: PRK15015 877468004652 Carbon starvation protein CstA; Region: CstA; pfam02554 877468004653 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 877468004654 Uncharacterized small protein [Function unknown]; Region: COG2879 877468004655 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 877468004656 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 877468004657 putative active site [active] 877468004658 metal binding site [ion binding]; metal-binding site 877468004659 methionine aminotransferase; Validated; Region: PRK09082 877468004660 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 877468004661 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468004662 homodimer interface [polypeptide binding]; other site 877468004663 catalytic residue [active] 877468004664 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 877468004665 ParB-like nuclease domain; Region: ParBc; pfam02195 877468004666 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 877468004667 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 877468004668 Active Sites [active] 877468004669 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 877468004670 Transcriptional regulator [Transcription]; Region: LysR; COG0583 877468004671 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468004672 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 877468004673 dimerization interface [polypeptide binding]; other site 877468004674 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 877468004675 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 877468004676 dimerization domain [polypeptide binding]; other site 877468004677 dimer interface [polypeptide binding]; other site 877468004678 catalytic residues [active] 877468004679 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 877468004680 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 877468004681 dimer interface [polypeptide binding]; other site 877468004682 decamer (pentamer of dimers) interface [polypeptide binding]; other site 877468004683 catalytic triad [active] 877468004684 peroxidatic and resolving cysteines [active] 877468004685 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 877468004686 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 877468004687 catalytic residue [active] 877468004688 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 877468004689 catalytic residues [active] 877468004690 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 877468004691 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 877468004692 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 877468004693 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 877468004694 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 877468004695 putative molybdopterin cofactor binding site [chemical binding]; other site 877468004696 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 877468004697 molybdopterin cofactor binding site; other site 877468004698 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 877468004699 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 877468004700 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 877468004701 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 877468004702 Ligand Binding Site [chemical binding]; other site 877468004703 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 877468004704 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 877468004705 NAD binding site [chemical binding]; other site 877468004706 catalytic Zn binding site [ion binding]; other site 877468004707 structural Zn binding site [ion binding]; other site 877468004708 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 877468004709 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 877468004710 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 877468004711 B1 nucleotide binding pocket [chemical binding]; other site 877468004712 B2 nucleotide binding pocket [chemical binding]; other site 877468004713 CAS motifs; other site 877468004714 active site 877468004715 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 877468004716 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 877468004717 transmembrane helices; other site 877468004718 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 877468004719 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 877468004720 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 877468004721 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 877468004722 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 877468004723 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 877468004724 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 877468004725 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 877468004726 putative active site [active] 877468004727 (T/H)XGH motif; other site 877468004728 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 877468004729 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 877468004730 putative active site [active] 877468004731 heme pocket [chemical binding]; other site 877468004732 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 877468004733 ATP binding site [chemical binding]; other site 877468004734 Mg2+ binding site [ion binding]; other site 877468004735 G-X-G motif; other site 877468004736 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 877468004737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 877468004738 active site 877468004739 phosphorylation site [posttranslational modification] 877468004740 intermolecular recognition site; other site 877468004741 dimerization interface [polypeptide binding]; other site 877468004742 Transcriptional regulator; Region: CitT; pfam12431 877468004743 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 877468004744 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 877468004745 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 877468004746 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 877468004747 DNA-binding site [nucleotide binding]; DNA binding site 877468004748 RNA-binding motif; other site 877468004749 chromosome condensation membrane protein; Provisional; Region: PRK14196 877468004750 Predicted amidohydrolase [General function prediction only]; Region: COG0388 877468004751 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 877468004752 putative active site [active] 877468004753 catalytic triad [active] 877468004754 putative dimer interface [polypeptide binding]; other site 877468004755 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 877468004756 lipoyl synthase; Provisional; Region: PRK05481 877468004757 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 877468004758 FeS/SAM binding site; other site 877468004759 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 877468004760 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468004761 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 877468004762 substrate binding pocket [chemical binding]; other site 877468004763 dimerization interface [polypeptide binding]; other site 877468004764 lipoate-protein ligase B; Provisional; Region: PRK14342 877468004765 hypothetical protein; Provisional; Region: PRK04998 877468004766 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 877468004767 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 877468004768 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 877468004769 rare lipoprotein A; Provisional; Region: PRK10672 877468004770 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 877468004771 Sporulation related domain; Region: SPOR; pfam05036 877468004772 cell wall shape-determining protein; Provisional; Region: PRK10794 877468004773 penicillin-binding protein 2; Provisional; Region: PRK10795 877468004774 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 877468004775 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 877468004776 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 877468004777 ribosome-associated protein; Provisional; Region: PRK11538 877468004778 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 877468004779 catalytic core [active] 877468004780 threonine-phosphate decarboxylase; Provisional; Region: PRK08056 877468004781 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 877468004782 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468004783 homodimer interface [polypeptide binding]; other site 877468004784 catalytic residue [active] 877468004785 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 877468004786 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 877468004787 active site 877468004788 (T/H)XGH motif; other site 877468004789 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 877468004790 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 877468004791 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 877468004792 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 877468004793 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 877468004794 HIGH motif; other site 877468004795 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 877468004796 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 877468004797 active site 877468004798 KMSKS motif; other site 877468004799 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 877468004800 tRNA binding surface [nucleotide binding]; other site 877468004801 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 877468004802 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 877468004803 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 877468004804 Propionate catabolism activator; Region: PrpR_N; pfam06506 877468004805 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 877468004806 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 877468004807 Walker A motif; other site 877468004808 ATP binding site [chemical binding]; other site 877468004809 Walker B motif; other site 877468004810 arginine finger; other site 877468004811 hypothetical protein; Provisional; Region: PRK11032 877468004812 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 877468004813 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 877468004814 Sel1-like repeats; Region: SEL1; smart00671 877468004815 Sel1-like repeats; Region: SEL1; smart00671 877468004816 Sel1-like repeats; Region: SEL1; smart00671 877468004817 Sel1-like repeats; Region: SEL1; smart00671 877468004818 Sel1-like repeats; Region: SEL1; smart00671 877468004819 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 877468004820 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 877468004821 HSP70 interaction site [polypeptide binding]; other site 877468004822 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 877468004823 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 877468004824 HSP70 interaction site [polypeptide binding]; other site 877468004825 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 877468004826 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 877468004827 nucleotide binding site [chemical binding]; other site 877468004828 putative NEF/HSP70 interaction site [polypeptide binding]; other site 877468004829 SBD interface [polypeptide binding]; other site 877468004830 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 877468004831 active site 877468004832 tetramer interface [polypeptide binding]; other site 877468004833 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 877468004834 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 877468004835 Walker A/P-loop; other site 877468004836 ATP binding site [chemical binding]; other site 877468004837 Q-loop/lid; other site 877468004838 ABC transporter signature motif; other site 877468004839 Walker B; other site 877468004840 D-loop; other site 877468004841 H-loop/switch region; other site 877468004842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468004843 dimer interface [polypeptide binding]; other site 877468004844 conserved gate region; other site 877468004845 putative PBP binding loops; other site 877468004846 ABC-ATPase subunit interface; other site 877468004847 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 877468004848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468004849 dimer interface [polypeptide binding]; other site 877468004850 conserved gate region; other site 877468004851 putative PBP binding loops; other site 877468004852 ABC-ATPase subunit interface; other site 877468004853 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 877468004854 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 877468004855 substrate binding pocket [chemical binding]; other site 877468004856 membrane-bound complex binding site; other site 877468004857 hinge residues; other site 877468004858 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 877468004859 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 877468004860 putative active site [active] 877468004861 catalytic triad [active] 877468004862 putative dimer interface [polypeptide binding]; other site 877468004863 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 877468004864 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 877468004865 Transporter associated domain; Region: CorC_HlyC; smart01091 877468004866 metal-binding heat shock protein; Provisional; Region: PRK00016 877468004867 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 877468004868 PhoH-like protein; Region: PhoH; pfam02562 877468004869 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 877468004870 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 877468004871 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 877468004872 FeS/SAM binding site; other site 877468004873 TRAM domain; Region: TRAM; pfam01938 877468004874 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 877468004875 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 877468004876 asparagine synthetase B; Provisional; Region: asnB; PRK09431 877468004877 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 877468004878 active site 877468004879 dimer interface [polypeptide binding]; other site 877468004880 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 877468004881 Ligand Binding Site [chemical binding]; other site 877468004882 Molecular Tunnel; other site 877468004883 UMP phosphatase; Provisional; Region: PRK10444 877468004884 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 877468004885 active site 877468004886 motif I; other site 877468004887 motif II; other site 877468004888 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 877468004889 MarR family; Region: MarR; pfam01047 877468004890 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 877468004891 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 877468004892 nucleotide binding site [chemical binding]; other site 877468004893 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 877468004894 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 877468004895 active site 877468004896 dimer interface [polypeptide binding]; other site 877468004897 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 877468004898 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 877468004899 active site 877468004900 trimer interface [polypeptide binding]; other site 877468004901 allosteric site; other site 877468004902 active site lid [active] 877468004903 hexamer (dimer of trimers) interface [polypeptide binding]; other site 877468004904 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 877468004905 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 877468004906 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 877468004907 active site turn [active] 877468004908 phosphorylation site [posttranslational modification] 877468004909 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 877468004910 HPr interaction site; other site 877468004911 glycerol kinase (GK) interaction site [polypeptide binding]; other site 877468004912 active site 877468004913 phosphorylation site [posttranslational modification] 877468004914 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 877468004915 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 877468004916 active site 877468004917 HIGH motif; other site 877468004918 nucleotide binding site [chemical binding]; other site 877468004919 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 877468004920 KMSKS motif; other site 877468004921 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 877468004922 outer membrane porin, OprD family; Region: OprD; pfam03573 877468004923 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 877468004924 YbfN-like lipoprotein; Region: YbfN; pfam13982 877468004925 citrate-proton symporter; Provisional; Region: PRK15075 877468004926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468004927 putative substrate translocation pore; other site 877468004928 tricarballylate utilization protein B; Provisional; Region: PRK15033 877468004929 tricarballylate dehydrogenase; Validated; Region: PRK08274 877468004930 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 877468004931 Transcriptional regulator [Transcription]; Region: LysR; COG0583 877468004932 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468004933 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 877468004934 putative dimerization interface [polypeptide binding]; other site 877468004935 ferric uptake regulator; Provisional; Region: fur; PRK09462 877468004936 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 877468004937 metal binding site 2 [ion binding]; metal-binding site 877468004938 putative DNA binding helix; other site 877468004939 metal binding site 1 [ion binding]; metal-binding site 877468004940 dimer interface [polypeptide binding]; other site 877468004941 structural Zn2+ binding site [ion binding]; other site 877468004942 flavodoxin FldA; Validated; Region: PRK09267 877468004943 LexA regulated protein; Provisional; Region: PRK11675 877468004944 acyl-CoA esterase; Provisional; Region: PRK10673 877468004945 PGAP1-like protein; Region: PGAP1; pfam07819 877468004946 replication initiation regulator SeqA; Provisional; Region: PRK11187 877468004947 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 877468004948 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 877468004949 active site 877468004950 substrate binding site [chemical binding]; other site 877468004951 metal binding site [ion binding]; metal-binding site 877468004952 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 877468004953 putrescine transporter; Provisional; Region: potE; PRK10655 877468004954 ornithine decarboxylase; Provisional; Region: PRK13578 877468004955 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 877468004956 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 877468004957 homodimer interface [polypeptide binding]; other site 877468004958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468004959 catalytic residue [active] 877468004960 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 877468004961 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 877468004962 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 877468004963 active site 877468004964 phosphorylation site [posttranslational modification] 877468004965 intermolecular recognition site; other site 877468004966 dimerization interface [polypeptide binding]; other site 877468004967 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 877468004968 DNA binding site [nucleotide binding] 877468004969 sensor protein KdpD; Provisional; Region: PRK10490 877468004970 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 877468004971 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 877468004972 Ligand Binding Site [chemical binding]; other site 877468004973 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 877468004974 GAF domain; Region: GAF_3; pfam13492 877468004975 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 877468004976 dimer interface [polypeptide binding]; other site 877468004977 phosphorylation site [posttranslational modification] 877468004978 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 877468004979 ATP binding site [chemical binding]; other site 877468004980 Mg2+ binding site [ion binding]; other site 877468004981 G-X-G motif; other site 877468004982 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 877468004983 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 877468004984 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 877468004985 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 877468004986 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 877468004987 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 877468004988 DNA photolyase; Region: DNA_photolyase; pfam00875 877468004989 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 877468004990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468004991 putative substrate translocation pore; other site 877468004992 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468004993 Uncharacterized conserved protein [Function unknown]; Region: COG0327 877468004994 metal-binding protein; Provisional; Region: PRK10799 877468004995 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 877468004996 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 877468004997 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 877468004998 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 877468004999 putative active site [active] 877468005000 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 877468005001 active site 877468005002 DNA binding site [nucleotide binding] 877468005003 Int/Topo IB signature motif; other site 877468005004 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 877468005005 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 877468005006 UDP-galactopyranose mutase; Region: GLF; pfam03275 877468005007 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 877468005008 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 877468005009 active site 877468005010 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 877468005011 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 877468005012 putative ADP-binding pocket [chemical binding]; other site 877468005013 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 877468005014 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 877468005015 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 877468005016 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 877468005017 Walker A/P-loop; other site 877468005018 ATP binding site [chemical binding]; other site 877468005019 Q-loop/lid; other site 877468005020 ABC transporter signature motif; other site 877468005021 Walker B; other site 877468005022 D-loop; other site 877468005023 H-loop/switch region; other site 877468005024 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 877468005025 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 877468005026 active site 877468005027 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 877468005028 active site 877468005029 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 877468005030 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 877468005031 endonuclease VIII; Provisional; Region: PRK10445 877468005032 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 877468005033 DNA binding site [nucleotide binding] 877468005034 catalytic residue [active] 877468005035 putative catalytic residues [active] 877468005036 H2TH interface [polypeptide binding]; other site 877468005037 intercalation triad [nucleotide binding]; other site 877468005038 substrate specificity determining residue; other site 877468005039 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 877468005040 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 877468005041 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 877468005042 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 877468005043 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 877468005044 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 877468005045 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 877468005046 dimer interface [polypeptide binding]; other site 877468005047 active site 877468005048 citrylCoA binding site [chemical binding]; other site 877468005049 NADH binding [chemical binding]; other site 877468005050 cationic pore residues; other site 877468005051 oxalacetate/citrate binding site [chemical binding]; other site 877468005052 coenzyme A binding site [chemical binding]; other site 877468005053 catalytic triad [active] 877468005054 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 877468005055 proximal heme binding site [chemical binding]; other site 877468005056 SdhD (CybS) interface [polypeptide binding]; other site 877468005057 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 877468005058 SdhC subunit interface [polypeptide binding]; other site 877468005059 proximal heme binding site [chemical binding]; other site 877468005060 cardiolipin binding site; other site 877468005061 Iron-sulfur protein interface; other site 877468005062 proximal quinone binding site [chemical binding]; other site 877468005063 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 877468005064 L-aspartate oxidase; Provisional; Region: PRK06175 877468005065 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 877468005066 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 877468005067 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 877468005068 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 877468005069 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 877468005070 TPP-binding site [chemical binding]; other site 877468005071 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 877468005072 dimer interface [polypeptide binding]; other site 877468005073 PYR/PP interface [polypeptide binding]; other site 877468005074 TPP binding site [chemical binding]; other site 877468005075 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 877468005076 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 877468005077 E3 interaction surface; other site 877468005078 lipoyl attachment site [posttranslational modification]; other site 877468005079 e3 binding domain; Region: E3_binding; pfam02817 877468005080 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 877468005081 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 877468005082 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 877468005083 CoA-ligase; Region: Ligase_CoA; pfam00549 877468005084 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 877468005085 CoA binding domain; Region: CoA_binding; smart00881 877468005086 CoA-ligase; Region: Ligase_CoA; pfam00549 877468005087 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 877468005088 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 877468005089 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 877468005090 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 877468005091 Predicted outer membrane lipoprotein [Function unknown]; Region: COG4890 877468005092 hypothetical protein; Provisional; Region: PRK10588 877468005093 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 877468005094 active site 877468005095 colicin uptake protein TolQ; Provisional; Region: PRK10801 877468005096 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 877468005097 colicin uptake protein TolR; Provisional; Region: PRK11024 877468005098 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 877468005099 TolA C-terminal; Region: TolA; pfam06519 877468005100 translocation protein TolB; Provisional; Region: tolB; PRK03629 877468005101 TolB amino-terminal domain; Region: TolB_N; pfam04052 877468005102 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 877468005103 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 877468005104 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 877468005105 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 877468005106 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 877468005107 ligand binding site [chemical binding]; other site 877468005108 tol-pal system protein YbgF; Provisional; Region: PRK10803 877468005109 Tetratricopeptide repeat; Region: TPR_6; pfam13174 877468005110 Tetratricopeptide repeat; Region: TPR_6; pfam13174 877468005111 quinolinate synthetase; Provisional; Region: PRK09375 877468005112 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 877468005113 zinc transporter ZitB; Provisional; Region: PRK03557 877468005114 YbgS-like protein; Region: YbgS; pfam13985 877468005115 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 877468005116 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 877468005117 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Region: FumA; COG1838 877468005118 fumarate hydratase; Provisional; Region: PRK06246 877468005119 Transcriptional regulator [Transcription]; Region: LysR; COG0583 877468005120 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468005121 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 877468005122 dimerization interface [polypeptide binding]; other site 877468005123 cell density-dependent motility repressor; Provisional; Region: PRK10082 877468005124 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468005125 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 877468005126 dimerization interface [polypeptide binding]; other site 877468005127 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 877468005128 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 877468005129 transmembrane helices; other site 877468005130 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 877468005131 oxaloacetate decarboxylase; Provisional; Region: PRK14040 877468005132 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 877468005133 active site 877468005134 catalytic residues [active] 877468005135 metal binding site [ion binding]; metal-binding site 877468005136 homodimer binding site [polypeptide binding]; other site 877468005137 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 877468005138 carboxyltransferase (CT) interaction site; other site 877468005139 biotinylation site [posttranslational modification]; other site 877468005140 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 877468005141 Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767 877468005142 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 877468005143 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 877468005144 dimer interface [polypeptide binding]; other site 877468005145 putative PBP binding regions; other site 877468005146 ABC-ATPase subunit interface; other site 877468005147 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 877468005148 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 877468005149 Walker A/P-loop; other site 877468005150 ATP binding site [chemical binding]; other site 877468005151 Q-loop/lid; other site 877468005152 ABC transporter signature motif; other site 877468005153 Walker B; other site 877468005154 D-loop; other site 877468005155 H-loop/switch region; other site 877468005156 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 877468005157 catalytic core [active] 877468005158 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 877468005159 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 877468005160 active site 877468005161 catalytic residues [active] 877468005162 galactokinase; Provisional; Region: PRK05101 877468005163 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 877468005164 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 877468005165 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 877468005166 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 877468005167 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 877468005168 dimer interface [polypeptide binding]; other site 877468005169 active site 877468005170 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 877468005171 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 877468005172 NAD binding site [chemical binding]; other site 877468005173 homodimer interface [polypeptide binding]; other site 877468005174 active site 877468005175 substrate binding site [chemical binding]; other site 877468005176 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4714 877468005177 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 877468005178 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 877468005179 Walker A/P-loop; other site 877468005180 ATP binding site [chemical binding]; other site 877468005181 Q-loop/lid; other site 877468005182 ABC transporter signature motif; other site 877468005183 Walker B; other site 877468005184 D-loop; other site 877468005185 H-loop/switch region; other site 877468005186 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 877468005187 Walker A/P-loop; other site 877468005188 ATP binding site [chemical binding]; other site 877468005189 Q-loop/lid; other site 877468005190 ABC transporter signature motif; other site 877468005191 Walker B; other site 877468005192 D-loop; other site 877468005193 H-loop/switch region; other site 877468005194 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 877468005195 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 877468005196 molybdenum-pterin binding domain; Region: Mop; TIGR00638 877468005197 TOBE domain; Region: TOBE; pfam03459 877468005198 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 877468005199 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 877468005200 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 877468005201 substrate binding pocket [chemical binding]; other site 877468005202 membrane-bound complex binding site; other site 877468005203 hinge residues; other site 877468005204 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 877468005205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468005206 dimer interface [polypeptide binding]; other site 877468005207 conserved gate region; other site 877468005208 putative PBP binding loops; other site 877468005209 ABC-ATPase subunit interface; other site 877468005210 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 877468005211 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 877468005212 Walker A/P-loop; other site 877468005213 ATP binding site [chemical binding]; other site 877468005214 Q-loop/lid; other site 877468005215 ABC transporter signature motif; other site 877468005216 Walker B; other site 877468005217 D-loop; other site 877468005218 H-loop/switch region; other site 877468005219 molybdenum-pterin binding domain; Region: Mop; TIGR00638 877468005220 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 877468005221 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 877468005222 active site 877468005223 motif I; other site 877468005224 motif II; other site 877468005225 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 877468005226 6-phosphogluconolactonase; Provisional; Region: PRK11028 877468005227 acyl-CoA thioesterase; Provisional; Region: PRK10531 877468005228 putative pectinesterase; Region: PLN02432; cl01911 877468005229 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 877468005230 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 877468005231 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 877468005232 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 877468005233 dimer interface [polypeptide binding]; other site 877468005234 active site 877468005235 Int/Topo IB signature motif; other site 877468005236 Protein of unknown function (DUF4014); Region: DUF4014; pfam13198 877468005237 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 877468005238 Protein of unknown function (DUF2737); Region: DUF2737; pfam10930 877468005239 Protein of unknown function (DUF2856); Region: DUF2856; pfam11043 877468005240 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 877468005241 active site 877468005242 catalytic site [active] 877468005243 substrate binding site [chemical binding]; other site 877468005244 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 877468005245 dimer interface [polypeptide binding]; other site 877468005246 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 877468005247 ssDNA binding site [nucleotide binding]; other site 877468005248 tetramer (dimer of dimers) interface [polypeptide binding]; other site 877468005249 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 877468005250 hypothetical protein; Provisional; Region: PRK09946 877468005251 Cro; Region: Cro; pfam09048 877468005252 Bacteriophage CII protein; Region: Phage_CII; pfam05269 877468005253 T5orf172 domain; Region: T5orf172; cl17462 877468005254 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 877468005255 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 877468005256 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 877468005257 Walker A motif; other site 877468005258 ATP binding site [chemical binding]; other site 877468005259 Walker B motif; other site 877468005260 arginine finger; other site 877468005261 Transcriptional regulator; Region: Rrf2; cl17282 877468005262 NinF protein; Region: NinF; pfam05810 877468005263 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 877468005264 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 877468005265 active site 877468005266 metal binding site [ion binding]; metal-binding site 877468005267 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 877468005268 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 877468005269 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 877468005270 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 877468005271 Protein of unknown function (DUF2560); Region: DUF2560; pfam10834 877468005272 hypothetical protein; Region: PHA00781 877468005273 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 877468005274 Phage terminase large subunit; Region: Terminase_3; pfam04466 877468005275 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 877468005276 P22 tail accessory factor; Region: P22_Tail-4; pfam11650 877468005277 Phage stabilisation protein; Region: Phage_stabilise; pfam11134 877468005278 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 877468005279 head assembly protein; Region: PHA00771 877468005280 Head binding; Region: Head_binding; pfam09008 877468005281 imidazolonepropionase; Validated; Region: PRK09356 877468005282 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 877468005283 active site 877468005284 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 877468005285 putative active site [active] 877468005286 putative metal binding site [ion binding]; other site 877468005287 histidine utilization repressor; Provisional; Region: PRK14999 877468005288 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 877468005289 DNA-binding site [nucleotide binding]; DNA binding site 877468005290 UTRA domain; Region: UTRA; pfam07702 877468005291 urocanate hydratase; Provisional; Region: PRK05414 877468005292 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 877468005293 active sites [active] 877468005294 tetramer interface [polypeptide binding]; other site 877468005295 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 877468005296 substrate binding site [chemical binding]; other site 877468005297 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 877468005298 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 877468005299 inhibitor-cofactor binding pocket; inhibition site 877468005300 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468005301 catalytic residue [active] 877468005302 biotin synthase; Provisional; Region: PRK15108 877468005303 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 877468005304 FeS/SAM binding site; other site 877468005305 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 877468005306 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 877468005307 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 877468005308 substrate-cofactor binding pocket; other site 877468005309 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468005310 catalytic residue [active] 877468005311 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 877468005312 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 877468005313 S-adenosylmethionine binding site [chemical binding]; other site 877468005314 AAA domain; Region: AAA_26; pfam13500 877468005315 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 877468005316 excinuclease ABC subunit B; Provisional; Region: PRK05298 877468005317 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 877468005318 ATP binding site [chemical binding]; other site 877468005319 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 877468005320 nucleotide binding region [chemical binding]; other site 877468005321 ATP-binding site [chemical binding]; other site 877468005322 Ultra-violet resistance protein B; Region: UvrB; pfam12344 877468005323 UvrB/uvrC motif; Region: UVR; pfam02151 877468005324 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 877468005325 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 877468005326 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 877468005327 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 877468005328 Leucine-rich repeats; other site 877468005329 Substrate binding site [chemical binding]; other site 877468005330 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 877468005331 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 877468005332 putative substrate binding pocket [chemical binding]; other site 877468005333 dimer interface [polypeptide binding]; other site 877468005334 phosphate binding site [ion binding]; other site 877468005335 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 877468005336 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 877468005337 FeS/SAM binding site; other site 877468005338 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 877468005339 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 877468005340 MPT binding site; other site 877468005341 trimer interface [polypeptide binding]; other site 877468005342 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 877468005343 trimer interface [polypeptide binding]; other site 877468005344 dimer interface [polypeptide binding]; other site 877468005345 putative active site [active] 877468005346 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 877468005347 MoaE interaction surface [polypeptide binding]; other site 877468005348 MoeB interaction surface [polypeptide binding]; other site 877468005349 thiocarboxylated glycine; other site 877468005350 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 877468005351 MoaE homodimer interface [polypeptide binding]; other site 877468005352 MoaD interaction [polypeptide binding]; other site 877468005353 active site residues [active] 877468005354 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 877468005355 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 877468005356 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 877468005357 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 877468005358 Predicted integral membrane protein [Function unknown]; Region: COG0392 877468005359 cardiolipin synthase 2; Provisional; Region: PRK11263 877468005360 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 877468005361 putative active site [active] 877468005362 catalytic site [active] 877468005363 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 877468005364 putative active site [active] 877468005365 catalytic site [active] 877468005366 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 877468005367 putative catalytic site [active] 877468005368 putative metal binding site [ion binding]; other site 877468005369 putative phosphate binding site [ion binding]; other site 877468005370 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 877468005371 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 877468005372 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 877468005373 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 877468005374 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 877468005375 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 877468005376 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 877468005377 Walker A/P-loop; other site 877468005378 ATP binding site [chemical binding]; other site 877468005379 Q-loop/lid; other site 877468005380 ABC transporter signature motif; other site 877468005381 Walker B; other site 877468005382 D-loop; other site 877468005383 H-loop/switch region; other site 877468005384 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 877468005385 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 877468005386 Walker A/P-loop; other site 877468005387 ATP binding site [chemical binding]; other site 877468005388 Q-loop/lid; other site 877468005389 ABC transporter signature motif; other site 877468005390 Walker B; other site 877468005391 D-loop; other site 877468005392 H-loop/switch region; other site 877468005393 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 877468005394 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 877468005395 HlyD family secretion protein; Region: HlyD_3; pfam13437 877468005396 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 877468005397 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 877468005398 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 877468005399 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 877468005400 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 877468005401 ATP binding site [chemical binding]; other site 877468005402 Mg++ binding site [ion binding]; other site 877468005403 motif III; other site 877468005404 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 877468005405 nucleotide binding region [chemical binding]; other site 877468005406 ATP-binding site [chemical binding]; other site 877468005407 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 877468005408 DEAD_2; Region: DEAD_2; pfam06733 877468005409 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 877468005410 glycosyl transferase family protein; Provisional; Region: PRK08136 877468005411 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 877468005412 hypothetical protein; Provisional; Region: PRK10259 877468005413 hypothetical protein; Provisional; Region: PRK11019 877468005414 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 877468005415 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 877468005416 putative mechanosensitive channel protein; Provisional; Region: PRK11465 877468005417 Mechanosensitive ion channel; Region: MS_channel; pfam00924 877468005418 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 877468005419 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 877468005420 Walker A/P-loop; other site 877468005421 ATP binding site [chemical binding]; other site 877468005422 Q-loop/lid; other site 877468005423 ABC transporter signature motif; other site 877468005424 Walker B; other site 877468005425 D-loop; other site 877468005426 H-loop/switch region; other site 877468005427 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 877468005428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468005429 dimer interface [polypeptide binding]; other site 877468005430 conserved gate region; other site 877468005431 putative PBP binding loops; other site 877468005432 ABC-ATPase subunit interface; other site 877468005433 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 877468005434 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 877468005435 substrate binding pocket [chemical binding]; other site 877468005436 membrane-bound complex binding site; other site 877468005437 hinge residues; other site 877468005438 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 877468005439 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 877468005440 dimerization interface [polypeptide binding]; other site 877468005441 DPS ferroxidase diiron center [ion binding]; other site 877468005442 ion pore; other site 877468005443 threonine and homoserine efflux system; Provisional; Region: PRK10532 877468005444 EamA-like transporter family; Region: EamA; pfam00892 877468005445 outer membrane protein X; Provisional; Region: ompX; PRK09408 877468005446 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 877468005447 Sulfatase; Region: Sulfatase; pfam00884 877468005448 manganese transport regulator MntR; Provisional; Region: PRK11050 877468005449 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 877468005450 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 877468005451 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 877468005452 transmembrane helices; other site 877468005453 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 877468005454 L,D-transpeptidase; Provisional; Region: PRK10260 877468005455 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 877468005456 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 877468005457 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 877468005458 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 877468005459 Walker A/P-loop; other site 877468005460 ATP binding site [chemical binding]; other site 877468005461 ABC transporter signature motif; other site 877468005462 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 877468005463 Walker B; other site 877468005464 ABC transporter; Region: ABC_tran_2; pfam12848 877468005465 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 877468005466 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 877468005467 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 877468005468 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 877468005469 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 877468005470 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 877468005471 active site 877468005472 motif I; other site 877468005473 motif II; other site 877468005474 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 877468005475 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 877468005476 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 877468005477 dimer interface [polypeptide binding]; other site 877468005478 active site 877468005479 glycine loop; other site 877468005480 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 877468005481 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 877468005482 FeS/SAM binding site; other site 877468005483 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 877468005484 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 877468005485 ATP binding site [chemical binding]; other site 877468005486 substrate interface [chemical binding]; other site 877468005487 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 877468005488 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 877468005489 dimer interface [polypeptide binding]; other site 877468005490 putative functional site; other site 877468005491 putative MPT binding site; other site 877468005492 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 877468005493 catalytic nucleophile [active] 877468005494 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 877468005495 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 877468005496 Walker A/P-loop; other site 877468005497 ATP binding site [chemical binding]; other site 877468005498 Q-loop/lid; other site 877468005499 ABC transporter signature motif; other site 877468005500 Walker B; other site 877468005501 D-loop; other site 877468005502 H-loop/switch region; other site 877468005503 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 877468005504 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 877468005505 Walker A/P-loop; other site 877468005506 ATP binding site [chemical binding]; other site 877468005507 Q-loop/lid; other site 877468005508 ABC transporter signature motif; other site 877468005509 Walker B; other site 877468005510 D-loop; other site 877468005511 H-loop/switch region; other site 877468005512 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 877468005513 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 877468005514 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 877468005515 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 877468005516 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468005517 dimer interface [polypeptide binding]; other site 877468005518 conserved gate region; other site 877468005519 putative PBP binding loops; other site 877468005520 ABC-ATPase subunit interface; other site 877468005521 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 877468005522 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 877468005523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468005524 dimer interface [polypeptide binding]; other site 877468005525 conserved gate region; other site 877468005526 putative PBP binding loops; other site 877468005527 ABC-ATPase subunit interface; other site 877468005528 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 877468005529 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 877468005530 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 877468005531 FeS/SAM binding site; other site 877468005532 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 877468005533 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 877468005534 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 877468005535 Ligand binding site [chemical binding]; other site 877468005536 Electron transfer flavoprotein domain; Region: ETF; pfam01012 877468005537 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 877468005538 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 877468005539 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 877468005540 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 877468005541 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 877468005542 active site 877468005543 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 877468005544 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 877468005545 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 877468005546 Transcriptional regulator [Transcription]; Region: LysR; COG0583 877468005547 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468005548 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 877468005549 putative dimerization interface [polypeptide binding]; other site 877468005550 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 877468005551 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 877468005552 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 877468005553 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 877468005554 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 877468005555 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 877468005556 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 877468005557 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 877468005558 putative C-terminal domain interface [polypeptide binding]; other site 877468005559 putative GSH binding site (G-site) [chemical binding]; other site 877468005560 putative dimer interface [polypeptide binding]; other site 877468005561 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 877468005562 putative N-terminal domain interface [polypeptide binding]; other site 877468005563 putative dimer interface [polypeptide binding]; other site 877468005564 putative substrate binding pocket (H-site) [chemical binding]; other site 877468005565 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 877468005566 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 877468005567 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 877468005568 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 877468005569 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 877468005570 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 877468005571 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 877468005572 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 877468005573 active site 877468005574 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 877468005575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468005576 putative substrate translocation pore; other site 877468005577 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 877468005578 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 877468005579 active site 877468005580 motif I; other site 877468005581 motif II; other site 877468005582 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 877468005583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468005584 putative substrate translocation pore; other site 877468005585 Major Facilitator Superfamily; Region: MFS_1; pfam07690 877468005586 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 877468005587 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 877468005588 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 877468005589 putative transporter; Provisional; Region: PRK04972 877468005590 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 877468005591 TrkA-C domain; Region: TrkA_C; pfam02080 877468005592 TrkA-C domain; Region: TrkA_C; pfam02080 877468005593 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 877468005594 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 877468005595 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 877468005596 GSH binding site [chemical binding]; other site 877468005597 catalytic residues [active] 877468005598 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 877468005599 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 877468005600 dimer interface [polypeptide binding]; other site 877468005601 FMN binding site [chemical binding]; other site 877468005602 NADPH bind site [chemical binding]; other site 877468005603 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 877468005604 RimK-like ATP-grasp domain; Region: RimK; pfam08443 877468005605 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 877468005606 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 877468005607 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 877468005608 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 877468005609 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 877468005610 Walker A/P-loop; other site 877468005611 ATP binding site [chemical binding]; other site 877468005612 Q-loop/lid; other site 877468005613 ABC transporter signature motif; other site 877468005614 Walker B; other site 877468005615 D-loop; other site 877468005616 H-loop/switch region; other site 877468005617 TOBE domain; Region: TOBE_2; pfam08402 877468005618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468005619 dimer interface [polypeptide binding]; other site 877468005620 conserved gate region; other site 877468005621 putative PBP binding loops; other site 877468005622 ABC-ATPase subunit interface; other site 877468005623 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 877468005624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468005625 dimer interface [polypeptide binding]; other site 877468005626 conserved gate region; other site 877468005627 putative PBP binding loops; other site 877468005628 ABC-ATPase subunit interface; other site 877468005629 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 877468005630 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 877468005631 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 877468005632 S-adenosylmethionine binding site [chemical binding]; other site 877468005633 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 877468005634 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 877468005635 active site 877468005636 P-loop; other site 877468005637 phosphorylation site [posttranslational modification] 877468005638 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 877468005639 Sulfatase; Region: Sulfatase; cl17466 877468005640 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 877468005641 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 877468005642 substrate binding pocket [chemical binding]; other site 877468005643 membrane-bound complex binding site; other site 877468005644 hinge residues; other site 877468005645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468005646 dimer interface [polypeptide binding]; other site 877468005647 conserved gate region; other site 877468005648 putative PBP binding loops; other site 877468005649 ABC-ATPase subunit interface; other site 877468005650 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 877468005651 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468005652 dimer interface [polypeptide binding]; other site 877468005653 conserved gate region; other site 877468005654 putative PBP binding loops; other site 877468005655 ABC-ATPase subunit interface; other site 877468005656 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 877468005657 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 877468005658 substrate binding pocket [chemical binding]; other site 877468005659 membrane-bound complex binding site; other site 877468005660 hinge residues; other site 877468005661 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 877468005662 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 877468005663 Walker A/P-loop; other site 877468005664 ATP binding site [chemical binding]; other site 877468005665 Q-loop/lid; other site 877468005666 ABC transporter signature motif; other site 877468005667 Walker B; other site 877468005668 D-loop; other site 877468005669 H-loop/switch region; other site 877468005670 putative lipoprotein; Provisional; Region: PRK10533 877468005671 hypothetical protein; Provisional; Region: PRK02877 877468005672 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 877468005673 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 877468005674 amidase catalytic site [active] 877468005675 Zn binding residues [ion binding]; other site 877468005676 substrate binding site [chemical binding]; other site 877468005677 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 877468005678 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 877468005679 NAD(P) binding site [chemical binding]; other site 877468005680 active site 877468005681 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 877468005682 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 877468005683 putative NAD(P) binding site [chemical binding]; other site 877468005684 putative active site [active] 877468005685 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 877468005686 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 877468005687 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 877468005688 tetramer interface [polypeptide binding]; other site 877468005689 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468005690 catalytic residue [active] 877468005691 pyruvate dehydrogenase; Provisional; Region: PRK09124 877468005692 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 877468005693 PYR/PP interface [polypeptide binding]; other site 877468005694 dimer interface [polypeptide binding]; other site 877468005695 tetramer interface [polypeptide binding]; other site 877468005696 TPP binding site [chemical binding]; other site 877468005697 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 877468005698 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 877468005699 TPP-binding site [chemical binding]; other site 877468005700 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 877468005701 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 877468005702 FAD binding pocket [chemical binding]; other site 877468005703 FAD binding motif [chemical binding]; other site 877468005704 phosphate binding motif [ion binding]; other site 877468005705 beta-alpha-beta structure motif; other site 877468005706 NAD binding pocket [chemical binding]; other site 877468005707 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 877468005708 catalytic loop [active] 877468005709 iron binding site [ion binding]; other site 877468005710 hybrid cluster protein; Provisional; Region: PRK05290 877468005711 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 877468005712 ACS interaction site; other site 877468005713 CODH interaction site; other site 877468005714 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 877468005715 hybrid metal cluster; other site 877468005716 Predicted membrane protein [Function unknown]; Region: COG2431 877468005717 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 877468005718 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 877468005719 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 877468005720 putative active site [active] 877468005721 putative metal-binding site [ion binding]; other site 877468005722 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 877468005723 macrolide transporter subunit MacA; Provisional; Region: PRK11578 877468005724 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 877468005725 HlyD family secretion protein; Region: HlyD_3; pfam13437 877468005726 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 877468005727 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 877468005728 Walker A/P-loop; other site 877468005729 ATP binding site [chemical binding]; other site 877468005730 Q-loop/lid; other site 877468005731 ABC transporter signature motif; other site 877468005732 Walker B; other site 877468005733 D-loop; other site 877468005734 H-loop/switch region; other site 877468005735 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 877468005736 FtsX-like permease family; Region: FtsX; pfam02687 877468005737 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 877468005738 DNA-binding site [nucleotide binding]; DNA binding site 877468005739 RNA-binding motif; other site 877468005740 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 877468005741 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 877468005742 Clp amino terminal domain; Region: Clp_N; pfam02861 877468005743 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 877468005744 Walker A motif; other site 877468005745 ATP binding site [chemical binding]; other site 877468005746 Walker B motif; other site 877468005747 arginine finger; other site 877468005748 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 877468005749 Walker A motif; other site 877468005750 ATP binding site [chemical binding]; other site 877468005751 Walker B motif; other site 877468005752 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 877468005753 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 877468005754 DNA binding site [nucleotide binding] 877468005755 active site 877468005756 Int/Topo IB signature motif; other site 877468005757 Isochorismatase family; Region: Isochorismatase; pfam00857 877468005758 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 877468005759 catalytic triad [active] 877468005760 dimer interface [polypeptide binding]; other site 877468005761 conserved cis-peptide bond; other site 877468005762 Pirin-related protein [General function prediction only]; Region: COG1741 877468005763 Pirin; Region: Pirin; pfam02678 877468005764 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 877468005765 LysR family transcriptional regulator; Provisional; Region: PRK14997 877468005766 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468005767 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 877468005768 putative effector binding pocket; other site 877468005769 putative dimerization interface [polypeptide binding]; other site 877468005770 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 877468005771 rRNA binding site [nucleotide binding]; other site 877468005772 predicted 30S ribosome binding site; other site 877468005773 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 877468005774 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 877468005775 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 877468005776 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 877468005777 Walker A/P-loop; other site 877468005778 ATP binding site [chemical binding]; other site 877468005779 Q-loop/lid; other site 877468005780 ABC transporter signature motif; other site 877468005781 Walker B; other site 877468005782 D-loop; other site 877468005783 H-loop/switch region; other site 877468005784 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 877468005785 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 877468005786 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 877468005787 Walker A/P-loop; other site 877468005788 ATP binding site [chemical binding]; other site 877468005789 Q-loop/lid; other site 877468005790 ABC transporter signature motif; other site 877468005791 Walker B; other site 877468005792 D-loop; other site 877468005793 H-loop/switch region; other site 877468005794 thioredoxin reductase; Provisional; Region: PRK10262 877468005795 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 877468005796 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 877468005797 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 877468005798 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 877468005799 putative DNA binding site [nucleotide binding]; other site 877468005800 putative Zn2+ binding site [ion binding]; other site 877468005801 AsnC family; Region: AsnC_trans_reg; pfam01037 877468005802 DNA translocase FtsK; Provisional; Region: PRK10263 877468005803 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 877468005804 DNA translocase FtsK; Provisional; Region: PRK10263 877468005805 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 877468005806 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 877468005807 periplasmic chaperone LolA; Region: lolA; TIGR00547 877468005808 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 877468005809 recombination factor protein RarA; Reviewed; Region: PRK13342 877468005810 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 877468005811 Walker A motif; other site 877468005812 ATP binding site [chemical binding]; other site 877468005813 Walker B motif; other site 877468005814 arginine finger; other site 877468005815 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 877468005816 seryl-tRNA synthetase; Provisional; Region: PRK05431 877468005817 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 877468005818 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 877468005819 dimer interface [polypeptide binding]; other site 877468005820 active site 877468005821 motif 1; other site 877468005822 motif 2; other site 877468005823 motif 3; other site 877468005824 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 877468005825 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 877468005826 putative [Fe4-S4] binding site [ion binding]; other site 877468005827 putative molybdopterin cofactor binding site [chemical binding]; other site 877468005828 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 877468005829 putative molybdopterin cofactor binding site; other site 877468005830 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 877468005831 4Fe-4S binding domain; Region: Fer4; pfam00037 877468005832 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 877468005833 putative MFS family transporter protein; Provisional; Region: PRK03633 877468005834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468005835 putative substrate translocation pore; other site 877468005836 inner membrane transporter YjeM; Provisional; Region: PRK15238 877468005837 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 877468005838 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 877468005839 FeS/SAM binding site; other site 877468005840 pathogenicity island 1 protein SopD2; Provisional; Region: PRK15380 877468005841 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 877468005842 Pyruvate formate lyase 1; Region: PFL1; cd01678 877468005843 coenzyme A binding site [chemical binding]; other site 877468005844 active site 877468005845 catalytic residues [active] 877468005846 glycine loop; other site 877468005847 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 877468005848 uncharacterized domain; Region: TIGR00702 877468005849 YcaO-like family; Region: YcaO; pfam02624 877468005850 Predicted membrane protein [Function unknown]; Region: COG2323 877468005851 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 877468005852 homodimer interface [polypeptide binding]; other site 877468005853 substrate-cofactor binding pocket; other site 877468005854 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468005855 catalytic residue [active] 877468005856 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 877468005857 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 877468005858 hinge; other site 877468005859 active site 877468005860 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 877468005861 cytidylate kinase; Provisional; Region: cmk; PRK00023 877468005862 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 877468005863 CMP-binding site; other site 877468005864 The sites determining sugar specificity; other site 877468005865 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 877468005866 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 877468005867 RNA binding site [nucleotide binding]; other site 877468005868 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 877468005869 RNA binding site [nucleotide binding]; other site 877468005870 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 877468005871 RNA binding site [nucleotide binding]; other site 877468005872 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 877468005873 RNA binding site [nucleotide binding]; other site 877468005874 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 877468005875 RNA binding site [nucleotide binding]; other site 877468005876 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 877468005877 IHF dimer interface [polypeptide binding]; other site 877468005878 IHF - DNA interface [nucleotide binding]; other site 877468005879 ComEC family competence protein; Provisional; Region: PRK11539 877468005880 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 877468005881 Competence protein; Region: Competence; pfam03772 877468005882 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 877468005883 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 877468005884 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 877468005885 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 877468005886 Walker A/P-loop; other site 877468005887 ATP binding site [chemical binding]; other site 877468005888 Q-loop/lid; other site 877468005889 ABC transporter signature motif; other site 877468005890 Walker B; other site 877468005891 D-loop; other site 877468005892 H-loop/switch region; other site 877468005893 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 877468005894 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 877468005895 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 877468005896 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 877468005897 hypothetical protein; Provisional; Region: PRK11827 877468005898 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 877468005899 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 877468005900 Ligand binding site; other site 877468005901 oligomer interface; other site 877468005902 hypothetical protein; Provisional; Region: PRK10593 877468005903 Uncharacterized conserved protein [Function unknown]; Region: COG1434 877468005904 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 877468005905 putative active site [active] 877468005906 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 877468005907 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 877468005908 S-adenosylmethionine binding site [chemical binding]; other site 877468005909 condesin subunit F; Provisional; Region: PRK05260 877468005910 condesin subunit E; Provisional; Region: PRK05256 877468005911 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 877468005912 P-loop containing region of AAA domain; Region: AAA_29; cl17516 877468005913 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 877468005914 murein L,D-transpeptidase; Provisional; Region: PRK10594 877468005915 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 877468005916 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 877468005917 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 877468005918 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 877468005919 Peptidase M15; Region: Peptidase_M15_3; cl01194 877468005920 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 877468005921 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 877468005922 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 877468005923 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468005924 homodimer interface [polypeptide binding]; other site 877468005925 catalytic residue [active] 877468005926 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 877468005927 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 877468005928 trimer interface [polypeptide binding]; other site 877468005929 eyelet of channel; other site 877468005930 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 877468005931 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 877468005932 putative dimer interface [polypeptide binding]; other site 877468005933 putative anticodon binding site; other site 877468005934 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 877468005935 homodimer interface [polypeptide binding]; other site 877468005936 motif 1; other site 877468005937 motif 2; other site 877468005938 active site 877468005939 motif 3; other site 877468005940 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 877468005941 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 877468005942 putative DNA binding site [nucleotide binding]; other site 877468005943 putative Zn2+ binding site [ion binding]; other site 877468005944 AsnC family; Region: AsnC_trans_reg; pfam01037 877468005945 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 877468005946 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 877468005947 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 877468005948 catalytic residue [active] 877468005949 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 877468005950 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 877468005951 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 877468005952 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 877468005953 active site 877468005954 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 877468005955 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 877468005956 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 877468005957 Int/Topo IB signature motif; other site 877468005958 RecT family; Region: RecT; pfam03837 877468005959 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 877468005960 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 877468005961 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 877468005962 primosomal protein DnaI; Provisional; Region: PRK02854 877468005963 putative replication protein; Provisional; Region: PRK12377 877468005964 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 877468005965 Walker A motif; other site 877468005966 ATP binding site [chemical binding]; other site 877468005967 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 877468005968 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 877468005969 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 877468005970 DinI-like family; Region: DinI; pfam06183 877468005971 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 877468005972 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 877468005973 Antitermination protein; Region: Antiterm; pfam03589 877468005974 Antitermination protein; Region: Antiterm; pfam03589 877468005975 PipA protein; Region: PipA; pfam07108 877468005976 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 877468005977 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 877468005978 catalytic residues [active] 877468005979 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 877468005980 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 877468005981 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 877468005982 Domain of unknown function (DUF1859); Region: DUF1859; pfam08948 877468005983 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 877468005984 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 877468005985 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 877468005986 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 877468005987 oligomer interface [polypeptide binding]; other site 877468005988 active site residues [active] 877468005989 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 877468005990 Uncharacterized conserved protein [Function unknown]; Region: COG5471 877468005991 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 877468005992 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 877468005993 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 877468005994 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 877468005995 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 877468005996 Minor tail protein T; Region: Phage_tail_T; cl05636 877468005997 Phage-related minor tail protein [Function unknown]; Region: COG5281 877468005998 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 877468005999 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 877468006000 Phage-related protein [Function unknown]; Region: COG4718 877468006001 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 877468006002 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cl00891 877468006003 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 877468006004 active site 877468006005 Cu2+ binding site [ion binding]; other site 877468006006 Zn2+ binding site [ion binding]; other site 877468006007 P-class dimer interface [polypeptide binding]; other site 877468006008 Phage-related protein [Function unknown]; Region: gp18; COG4672 877468006009 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 877468006010 MPN+ (JAMM) motif; other site 877468006011 Zinc-binding site [ion binding]; other site 877468006012 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 877468006013 NlpC/P60 family; Region: NLPC_P60; cl17555 877468006014 Phage-related protein, tail component [Function unknown]; Region: COG4723 877468006015 Phage-related protein, tail component [Function unknown]; Region: COG4733 877468006016 Putative phage tail protein; Region: Phage-tail_3; pfam13550 877468006017 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 877468006018 Interdomain contacts; other site 877468006019 Cytokine receptor motif; other site 877468006020 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 877468006021 Fibronectin type III protein; Region: DUF3672; pfam12421 877468006022 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 877468006023 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 877468006024 Phage Tail Collar Domain; Region: Collar; pfam07484 877468006025 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 877468006026 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 877468006027 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 877468006028 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 877468006029 hypothetical protein; Provisional; Region: PRK09951 877468006030 DinI-like family; Region: DinI; cl11630 877468006031 aminopeptidase N; Provisional; Region: pepN; PRK14015 877468006032 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 877468006033 active site 877468006034 Zn binding site [ion binding]; other site 877468006035 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 877468006036 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 877468006037 quinone interaction residues [chemical binding]; other site 877468006038 active site 877468006039 catalytic residues [active] 877468006040 FMN binding site [chemical binding]; other site 877468006041 substrate binding site [chemical binding]; other site 877468006042 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 877468006043 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 877468006044 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 877468006045 MOSC domain; Region: MOSC; pfam03473 877468006046 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 877468006047 catalytic loop [active] 877468006048 iron binding site [ion binding]; other site 877468006049 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 877468006050 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 877468006051 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 877468006052 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 877468006053 S-adenosylmethionine binding site [chemical binding]; other site 877468006054 ABC transporter ATPase component; Reviewed; Region: PRK11147 877468006055 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 877468006056 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 877468006057 Walker A/P-loop; other site 877468006058 Walker A/P-loop; other site 877468006059 ATP binding site [chemical binding]; other site 877468006060 ATP binding site [chemical binding]; other site 877468006061 Q-loop/lid; other site 877468006062 Q-loop/lid; other site 877468006063 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 877468006064 ABC transporter signature motif; other site 877468006065 Walker B; other site 877468006066 D-loop; other site 877468006067 ABC transporter; Region: ABC_tran_2; pfam12848 877468006068 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 877468006069 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 877468006070 Paraquat-inducible protein A; Region: PqiA; pfam04403 877468006071 Paraquat-inducible protein A; Region: PqiA; pfam04403 877468006072 paraquat-inducible protein B; Provisional; Region: PRK10807 877468006073 mce related protein; Region: MCE; pfam02470 877468006074 mce related protein; Region: MCE; pfam02470 877468006075 mce related protein; Region: MCE; pfam02470 877468006076 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 877468006077 Protein of unknown function (DUF330); Region: DUF330; pfam03886 877468006078 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 877468006079 active site 1 [active] 877468006080 dimer interface [polypeptide binding]; other site 877468006081 active site 2 [active] 877468006082 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 877468006083 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 877468006084 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 877468006085 outer membrane protein A; Reviewed; Region: PRK10808 877468006086 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 877468006087 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 877468006088 ligand binding site [chemical binding]; other site 877468006089 cell division inhibitor SulA; Region: sula; TIGR00623 877468006090 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 877468006091 TfoX C-terminal domain; Region: TfoX_C; pfam04994 877468006092 TIGR01666 family membrane protein; Region: YCCS 877468006093 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 877468006094 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 877468006095 Predicted membrane protein [Function unknown]; Region: COG3304 877468006096 Domain of unknown function (DUF307); Region: DUF307; pfam03733 877468006097 Domain of unknown function (DUF307); Region: DUF307; pfam03733 877468006098 DNA helicase IV; Provisional; Region: helD; PRK11054 877468006099 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 877468006100 Part of AAA domain; Region: AAA_19; pfam13245 877468006101 Family description; Region: UvrD_C_2; pfam13538 877468006102 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 877468006103 active site 877468006104 dimer interfaces [polypeptide binding]; other site 877468006105 catalytic residues [active] 877468006106 hypothetical protein; Provisional; Region: PRK03641 877468006107 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 877468006108 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 877468006109 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; cl01548 877468006110 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 877468006111 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 877468006112 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 877468006113 putative RNA binding site [nucleotide binding]; other site 877468006114 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 877468006115 S-adenosylmethionine binding site [chemical binding]; other site 877468006116 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 877468006117 substrate binding site [chemical binding]; other site 877468006118 Cupin domain; Region: Cupin_2; cl17218 877468006119 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 877468006120 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 877468006121 acylphosphatase; Provisional; Region: PRK14426 877468006122 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 877468006123 sulfur transfer protein TusE; Provisional; Region: PRK11508 877468006124 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 877468006125 YccA-like proteins; Region: YccA_like; cd10433 877468006126 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 877468006127 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 877468006128 active site 877468006129 DNA binding site [nucleotide binding] 877468006130 Int/Topo IB signature motif; other site 877468006131 Domain of unknown function (DUF4224); Region: DUF4224; pfam13986 877468006132 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 877468006133 exonuclease VIII; Reviewed; Region: PRK09709 877468006134 exonuclease VIII; Reviewed; Region: PRK09709 877468006135 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 877468006136 Helix-turn-helix domain; Region: HTH_36; pfam13730 877468006137 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 877468006138 replicative DNA helicase; Region: DnaB; TIGR00665 877468006139 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 877468006140 Walker A motif; other site 877468006141 ATP binding site [chemical binding]; other site 877468006142 Walker B motif; other site 877468006143 DNA binding loops [nucleotide binding] 877468006144 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 877468006145 MT-A70; Region: MT-A70; cl01947 877468006146 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 877468006147 Protein of unknown function (DUF1133); Region: DUF1133; pfam06576 877468006148 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 877468006149 catalytic residues [active] 877468006150 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 877468006151 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 877468006152 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 877468006153 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 877468006154 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 877468006155 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834 877468006156 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 877468006157 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 877468006158 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 877468006159 Protein of unknown function (DUF3277); Region: DUF3277; pfam11681 877468006160 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 877468006161 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 877468006162 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 877468006163 N-acetyl-D-glucosamine binding site [chemical binding]; other site 877468006164 catalytic residue [active] 877468006165 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 877468006166 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 877468006167 Baseplate J-like protein; Region: Baseplate_J; cl01294 877468006168 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 877468006169 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 877468006170 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 877468006171 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 877468006172 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 877468006173 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 877468006174 PipA protein; Region: PipA; pfam07108 877468006175 secreted effector protein PipB; Provisional; Region: PRK15197 877468006176 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 877468006177 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 877468006178 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 877468006179 type III secretion chaperone protein SigE; Provisional; Region: PRK15202 877468006180 inositol phosphate phosphatase SopB; Provisional; Region: PRK15378 877468006181 Enterobacterial virulence protein IpgD; Region: IpgD; pfam05925 877468006182 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 877468006183 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 877468006184 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 877468006185 HAMP domain; Region: HAMP; pfam00672 877468006186 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 877468006187 dimer interface [polypeptide binding]; other site 877468006188 phosphorylation site [posttranslational modification] 877468006189 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 877468006190 ATP binding site [chemical binding]; other site 877468006191 Mg2+ binding site [ion binding]; other site 877468006192 G-X-G motif; other site 877468006193 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 877468006194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 877468006195 active site 877468006196 phosphorylation site [posttranslational modification] 877468006197 intermolecular recognition site; other site 877468006198 dimerization interface [polypeptide binding]; other site 877468006199 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 877468006200 DNA binding site [nucleotide binding] 877468006201 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 877468006202 active site 877468006203 homotetramer interface [polypeptide binding]; other site 877468006204 4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486 877468006205 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 877468006206 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 877468006207 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 877468006208 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 877468006209 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203 877468006210 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 877468006211 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 877468006212 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 877468006213 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 877468006214 NAD binding site [chemical binding]; other site 877468006215 catalytic residues [active] 877468006216 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 877468006217 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 877468006218 putative active site [active] 877468006219 putative metal binding site [ion binding]; other site 877468006220 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 877468006221 putative substrate binding pocket [chemical binding]; other site 877468006222 trimer interface [polypeptide binding]; other site 877468006223 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 877468006224 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 877468006225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468006226 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 877468006227 putative substrate translocation pore; other site 877468006228 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 877468006229 Cupin domain; Region: Cupin_2; pfam07883 877468006230 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 877468006231 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 877468006232 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 877468006233 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 877468006234 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 877468006235 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 877468006236 HSP70 interaction site [polypeptide binding]; other site 877468006237 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 877468006238 substrate binding site [polypeptide binding]; other site 877468006239 dimer interface [polypeptide binding]; other site 877468006240 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 877468006241 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 877468006242 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 877468006243 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 877468006244 DsbD alpha interface [polypeptide binding]; other site 877468006245 catalytic residues [active] 877468006246 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 877468006247 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 877468006248 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 877468006249 catalytic residues [active] 877468006250 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 877468006251 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 877468006252 catalytic residues [active] 877468006253 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 877468006254 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 877468006255 catalytic core [active] 877468006256 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 877468006257 hypothetical protein; Provisional; Region: PRK10174 877468006258 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 877468006259 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 877468006260 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 877468006261 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 877468006262 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 877468006263 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 877468006264 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 877468006265 Predicted transcriptional regulator [Transcription]; Region: COG3905 877468006266 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 877468006267 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 877468006268 Glutamate binding site [chemical binding]; other site 877468006269 NAD binding site [chemical binding]; other site 877468006270 catalytic residues [active] 877468006271 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 877468006272 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 877468006273 Na binding site [ion binding]; other site 877468006274 hypothetical protein; Provisional; Region: PRK10536 877468006275 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 877468006276 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 877468006277 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 877468006278 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 877468006279 putative active site [active] 877468006280 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 877468006281 Na binding site [ion binding]; other site 877468006282 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 877468006283 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 877468006284 putative active site cavity [active] 877468006285 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 877468006286 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 877468006287 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178 877468006288 putative sialic acid transporter; Provisional; Region: PRK12307 877468006289 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468006290 putative substrate translocation pore; other site 877468006291 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 877468006292 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 877468006293 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 877468006294 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 877468006295 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 877468006296 putative ligand binding site [chemical binding]; other site 877468006297 NAD binding site [chemical binding]; other site 877468006298 dimerization interface [polypeptide binding]; other site 877468006299 catalytic site [active] 877468006300 putative hydrolase; Validated; Region: PRK09248 877468006301 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 877468006302 active site 877468006303 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 877468006304 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 877468006305 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 877468006306 curli assembly protein CsgF; Provisional; Region: PRK10050 877468006307 curli assembly protein CsgE; Provisional; Region: PRK10386 877468006308 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 877468006309 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 877468006310 DNA binding residues [nucleotide binding] 877468006311 dimerization interface [polypeptide binding]; other site 877468006312 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 877468006313 Curlin associated repeat; Region: Curlin_rpt; pfam07012 877468006314 Curlin associated repeat; Region: Curlin_rpt; pfam07012 877468006315 major curlin subunit; Provisional; Region: csgA; PRK10051 877468006316 Curlin associated repeat; Region: Curlin_rpt; pfam07012 877468006317 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 877468006318 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 877468006319 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 877468006320 putative ADP-ribose binding site [chemical binding]; other site 877468006321 putative active site [active] 877468006322 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 877468006323 PLD-like domain; Region: PLDc_2; pfam13091 877468006324 putative active site [active] 877468006325 catalytic site [active] 877468006326 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 877468006327 PLD-like domain; Region: PLDc_2; pfam13091 877468006328 putative active site [active] 877468006329 catalytic site [active] 877468006330 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 877468006331 Acyltransferase family; Region: Acyl_transf_3; pfam01757 877468006332 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 877468006333 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 877468006334 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 877468006335 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 877468006336 Ligand binding site; other site 877468006337 DXD motif; other site 877468006338 lipoprotein; Provisional; Region: PRK10175 877468006339 secY/secA suppressor protein; Provisional; Region: PRK11467 877468006340 drug efflux system protein MdtG; Provisional; Region: PRK09874 877468006341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468006342 putative substrate translocation pore; other site 877468006343 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 877468006344 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 877468006345 putative acyl-acceptor binding pocket; other site 877468006346 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 877468006347 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 877468006348 active site residue [active] 877468006349 hypothetical protein; Provisional; Region: PRK03757 877468006350 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 877468006351 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 877468006352 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 877468006353 hydroxyglutarate oxidase; Provisional; Region: PRK11728 877468006354 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 877468006355 DNA damage-inducible protein I; Provisional; Region: PRK10597 877468006356 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 877468006357 active site 877468006358 dimer interface [polypeptide binding]; other site 877468006359 substrate binding pocket [chemical binding]; other site 877468006360 lipoprotein; Provisional; Region: PRK10598 877468006361 glutaredoxin 2; Provisional; Region: PRK10387 877468006362 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 877468006363 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 877468006364 N-terminal domain interface [polypeptide binding]; other site 877468006365 multidrug resistance protein MdtH; Provisional; Region: PRK11646 877468006366 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468006367 putative substrate translocation pore; other site 877468006368 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 877468006369 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 877468006370 hypothetical protein; Provisional; Region: PRK11239 877468006371 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 877468006372 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 877468006373 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 877468006374 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 877468006375 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 877468006376 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 877468006377 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 877468006378 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 877468006379 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 877468006380 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 877468006381 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 877468006382 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 877468006383 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 877468006384 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 877468006385 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 877468006386 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 877468006387 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 877468006388 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 877468006389 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 877468006390 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 877468006391 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 877468006392 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 877468006393 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 877468006394 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 877468006395 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 877468006396 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 877468006397 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 877468006398 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 877468006399 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 877468006400 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 877468006401 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 877468006402 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 877468006403 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 877468006404 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 877468006405 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 877468006406 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 877468006407 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 877468006408 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 877468006409 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 877468006410 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 877468006411 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 877468006412 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 877468006413 homodimer interface [polypeptide binding]; other site 877468006414 oligonucleotide binding site [chemical binding]; other site 877468006415 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 877468006416 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 877468006417 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 877468006418 RNA binding surface [nucleotide binding]; other site 877468006419 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 877468006420 active site 877468006421 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 877468006422 Maf-like protein; Region: Maf; pfam02545 877468006423 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 877468006424 active site 877468006425 dimer interface [polypeptide binding]; other site 877468006426 hypothetical protein; Provisional; Region: PRK11193 877468006427 putative phosphate acyltransferase; Provisional; Region: PRK05331 877468006428 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 877468006429 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 877468006430 dimer interface [polypeptide binding]; other site 877468006431 active site 877468006432 CoA binding pocket [chemical binding]; other site 877468006433 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 877468006434 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 877468006435 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 877468006436 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 877468006437 NAD(P) binding site [chemical binding]; other site 877468006438 homotetramer interface [polypeptide binding]; other site 877468006439 homodimer interface [polypeptide binding]; other site 877468006440 active site 877468006441 acyl carrier protein; Provisional; Region: acpP; PRK00982 877468006442 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 877468006443 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 877468006444 dimer interface [polypeptide binding]; other site 877468006445 active site 877468006446 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 877468006447 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 877468006448 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468006449 catalytic residue [active] 877468006450 conserved hypothetical protein, YceG family; Region: TIGR00247 877468006451 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 877468006452 dimerization interface [polypeptide binding]; other site 877468006453 thymidylate kinase; Validated; Region: tmk; PRK00698 877468006454 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 877468006455 TMP-binding site; other site 877468006456 ATP-binding site [chemical binding]; other site 877468006457 DNA polymerase III subunit delta'; Validated; Region: PRK07993 877468006458 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 877468006459 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 877468006460 active site 877468006461 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 877468006462 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 877468006463 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 877468006464 active site turn [active] 877468006465 phosphorylation site [posttranslational modification] 877468006466 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 877468006467 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 877468006468 N-terminal plug; other site 877468006469 ligand-binding site [chemical binding]; other site 877468006470 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 877468006471 nucleotide binding site/active site [active] 877468006472 HIT family signature motif; other site 877468006473 catalytic residue [active] 877468006474 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 877468006475 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 877468006476 putative dimer interface [polypeptide binding]; other site 877468006477 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 877468006478 thiamine kinase; Region: ycfN_thiK; TIGR02721 877468006479 thiamine kinase; Provisional; Region: thiK; PRK10271 877468006480 substrate binding site [chemical binding]; other site 877468006481 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 877468006482 beta-hexosaminidase; Provisional; Region: PRK05337 877468006483 hypothetical protein; Provisional; Region: PRK04940 877468006484 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 877468006485 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 877468006486 hypothetical protein; Provisional; Region: PRK11280 877468006487 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 877468006488 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 877468006489 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 877468006490 L,D-transpeptidase; Provisional; Region: PRK10190 877468006491 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 877468006492 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 877468006493 transcription-repair coupling factor; Provisional; Region: PRK10689 877468006494 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 877468006495 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 877468006496 ATP binding site [chemical binding]; other site 877468006497 putative Mg++ binding site [ion binding]; other site 877468006498 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 877468006499 nucleotide binding region [chemical binding]; other site 877468006500 ATP-binding site [chemical binding]; other site 877468006501 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 877468006502 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 877468006503 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 877468006504 FtsX-like permease family; Region: FtsX; pfam02687 877468006505 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 877468006506 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 877468006507 Walker A/P-loop; other site 877468006508 ATP binding site [chemical binding]; other site 877468006509 Q-loop/lid; other site 877468006510 ABC transporter signature motif; other site 877468006511 Walker B; other site 877468006512 D-loop; other site 877468006513 H-loop/switch region; other site 877468006514 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 877468006515 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 877468006516 FtsX-like permease family; Region: FtsX; pfam02687 877468006517 fructokinase; Reviewed; Region: PRK09557 877468006518 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 877468006519 nucleotide binding site [chemical binding]; other site 877468006520 NAD-dependent deacetylase; Provisional; Region: PRK00481 877468006521 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 877468006522 NAD+ binding site [chemical binding]; other site 877468006523 substrate binding site [chemical binding]; other site 877468006524 Zn binding site [ion binding]; other site 877468006525 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 877468006526 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 877468006527 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 877468006528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468006529 dimer interface [polypeptide binding]; other site 877468006530 conserved gate region; other site 877468006531 putative PBP binding loops; other site 877468006532 ABC-ATPase subunit interface; other site 877468006533 Sif protein; Region: Sif; pfam06767 877468006534 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 877468006535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468006536 dimer interface [polypeptide binding]; other site 877468006537 conserved gate region; other site 877468006538 putative PBP binding loops; other site 877468006539 ABC-ATPase subunit interface; other site 877468006540 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 877468006541 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 877468006542 Walker A/P-loop; other site 877468006543 ATP binding site [chemical binding]; other site 877468006544 Q-loop/lid; other site 877468006545 ABC transporter signature motif; other site 877468006546 Walker B; other site 877468006547 D-loop; other site 877468006548 H-loop/switch region; other site 877468006549 TOBE domain; Region: TOBE_2; pfam08402 877468006550 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 877468006551 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 877468006552 metal binding site [ion binding]; metal-binding site 877468006553 dimer interface [polypeptide binding]; other site 877468006554 Uncharacterized conserved protein [Function unknown]; Region: COG2850 877468006555 Cupin domain; Region: Cupin_2; cl17218 877468006556 sensor protein PhoQ; Provisional; Region: PRK10815 877468006557 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 877468006558 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 877468006559 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 877468006560 ATP binding site [chemical binding]; other site 877468006561 Mg2+ binding site [ion binding]; other site 877468006562 G-X-G motif; other site 877468006563 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 877468006564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 877468006565 active site 877468006566 phosphorylation site [posttranslational modification] 877468006567 intermolecular recognition site; other site 877468006568 dimerization interface [polypeptide binding]; other site 877468006569 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 877468006570 DNA binding site [nucleotide binding] 877468006571 adenylosuccinate lyase; Provisional; Region: PRK09285 877468006572 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 877468006573 tetramer interface [polypeptide binding]; other site 877468006574 active site 877468006575 putative lysogenization regulator; Reviewed; Region: PRK00218 877468006576 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 877468006577 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 877468006578 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 877468006579 nudix motif; other site 877468006580 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 877468006581 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 877468006582 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 877468006583 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 877468006584 probable active site [active] 877468006585 isocitrate dehydrogenase; Validated; Region: PRK07362 877468006586 isocitrate dehydrogenase; Reviewed; Region: PRK07006 877468006587 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 877468006588 DinI-like family; Region: DinI; cl11630 877468006589 DinI-like family; Region: DinI; cl11630 877468006590 Ricin-type beta-trefoil; Region: RICIN; smart00458 877468006591 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 877468006592 putative sugar binding sites [chemical binding]; other site 877468006593 Q-X-W motif; other site 877468006594 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 877468006595 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 877468006596 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 877468006597 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604 877468006598 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 877468006599 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 877468006600 putative dimer interface [polypeptide binding]; other site 877468006601 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 877468006602 BNR repeat-like domain; Region: BNR_2; pfam13088 877468006603 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 877468006604 TRL-like protein family; Region: TRL; pfam13146 877468006605 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 877468006606 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 877468006607 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 877468006608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468006609 dimer interface [polypeptide binding]; other site 877468006610 conserved gate region; other site 877468006611 ABC-ATPase subunit interface; other site 877468006612 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 877468006613 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468006614 dimer interface [polypeptide binding]; other site 877468006615 conserved gate region; other site 877468006616 putative PBP binding loops; other site 877468006617 ABC-ATPase subunit interface; other site 877468006618 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 877468006619 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 877468006620 Walker A/P-loop; other site 877468006621 ATP binding site [chemical binding]; other site 877468006622 Q-loop/lid; other site 877468006623 ABC transporter signature motif; other site 877468006624 Walker B; other site 877468006625 D-loop; other site 877468006626 H-loop/switch region; other site 877468006627 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 877468006628 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 877468006629 Walker A/P-loop; other site 877468006630 ATP binding site [chemical binding]; other site 877468006631 Q-loop/lid; other site 877468006632 ABC transporter signature motif; other site 877468006633 Walker B; other site 877468006634 D-loop; other site 877468006635 H-loop/switch region; other site 877468006636 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 877468006637 Mechanosensitive ion channel; Region: MS_channel; pfam00924 877468006638 zinc/cadmium-binding protein; Provisional; Region: PRK10306 877468006639 aminoglycoside resistance protein; Provisional; Region: PRK13746 877468006640 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 877468006641 active site 877468006642 NTP binding site [chemical binding]; other site 877468006643 metal binding triad [ion binding]; metal-binding site 877468006644 antibiotic binding site [chemical binding]; other site 877468006645 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 877468006646 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 877468006647 DNA binding residues [nucleotide binding] 877468006648 transcriptional regulator MirA; Provisional; Region: PRK15043 877468006649 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 877468006650 DNA binding residues [nucleotide binding] 877468006651 dimer interface [polypeptide binding]; other site 877468006652 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 877468006653 chorismate mutase; Provisional; Region: PRK08055 877468006654 leucine export protein LeuE; Provisional; Region: PRK10958 877468006655 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 877468006656 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 877468006657 hypothetical protein; Provisional; Region: PRK10457 877468006658 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 877468006659 Domain of unknown function (DUF333); Region: DUF333; pfam03891 877468006660 Uncharacterized conserved protein [Function unknown]; Region: COG3189 877468006661 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 877468006662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468006663 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 877468006664 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 877468006665 Predicted membrane protein [Function unknown]; Region: COG2707 877468006666 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 877468006667 putative deacylase active site [active] 877468006668 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 877468006669 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 877468006670 metal binding site [ion binding]; metal-binding site 877468006671 active site 877468006672 I-site; other site 877468006673 hypothetical protein; Provisional; Region: PRK05325 877468006674 PrkA family serine protein kinase; Provisional; Region: PRK15455 877468006675 AAA ATPase domain; Region: AAA_16; pfam13191 877468006676 Walker A motif; other site 877468006677 ATP binding site [chemical binding]; other site 877468006678 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 877468006679 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 877468006680 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 877468006681 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 877468006682 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 877468006683 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 877468006684 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 877468006685 active site 877468006686 catalytic tetrad [active] 877468006687 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 877468006688 active site 877468006689 phosphate binding residues; other site 877468006690 catalytic residues [active] 877468006691 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 877468006692 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 877468006693 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 877468006694 methionine sulfoxide reductase B; Provisional; Region: PRK00222 877468006695 SelR domain; Region: SelR; pfam01641 877468006696 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 877468006697 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 877468006698 Isochorismatase family; Region: Isochorismatase; pfam00857 877468006699 catalytic triad [active] 877468006700 metal binding site [ion binding]; metal-binding site 877468006701 conserved cis-peptide bond; other site 877468006702 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 877468006703 active site 877468006704 homodimer interface [polypeptide binding]; other site 877468006705 protease 4; Provisional; Region: PRK10949 877468006706 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 877468006707 tandem repeat interface [polypeptide binding]; other site 877468006708 oligomer interface [polypeptide binding]; other site 877468006709 active site residues [active] 877468006710 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 877468006711 tandem repeat interface [polypeptide binding]; other site 877468006712 oligomer interface [polypeptide binding]; other site 877468006713 active site residues [active] 877468006714 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 877468006715 putative FMN binding site [chemical binding]; other site 877468006716 selenophosphate synthetase; Provisional; Region: PRK00943 877468006717 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 877468006718 dimerization interface [polypeptide binding]; other site 877468006719 putative ATP binding site [chemical binding]; other site 877468006720 DNA topoisomerase III; Provisional; Region: PRK07726 877468006721 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 877468006722 active site 877468006723 putative interdomain interaction site [polypeptide binding]; other site 877468006724 putative metal-binding site [ion binding]; other site 877468006725 putative nucleotide binding site [chemical binding]; other site 877468006726 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 877468006727 domain I; other site 877468006728 DNA binding groove [nucleotide binding] 877468006729 phosphate binding site [ion binding]; other site 877468006730 domain II; other site 877468006731 domain III; other site 877468006732 nucleotide binding site [chemical binding]; other site 877468006733 catalytic site [active] 877468006734 domain IV; other site 877468006735 glutamate dehydrogenase; Provisional; Region: PRK09414 877468006736 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 877468006737 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 877468006738 NAD(P) binding site [chemical binding]; other site 877468006739 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 877468006740 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 877468006741 active site 877468006742 8-oxo-dGMP binding site [chemical binding]; other site 877468006743 nudix motif; other site 877468006744 metal binding site [ion binding]; metal-binding site 877468006745 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 877468006746 putative catalytic site [active] 877468006747 putative phosphate binding site [ion binding]; other site 877468006748 active site 877468006749 metal binding site A [ion binding]; metal-binding site 877468006750 DNA binding site [nucleotide binding] 877468006751 putative AP binding site [nucleotide binding]; other site 877468006752 putative metal binding site B [ion binding]; other site 877468006753 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 877468006754 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 877468006755 inhibitor-cofactor binding pocket; inhibition site 877468006756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468006757 catalytic residue [active] 877468006758 arginine succinyltransferase; Provisional; Region: PRK10456 877468006759 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 877468006760 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 877468006761 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 877468006762 NAD(P) binding site [chemical binding]; other site 877468006763 catalytic residues [active] 877468006764 succinylarginine dihydrolase; Provisional; Region: PRK13281 877468006765 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 877468006766 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 877468006767 putative active site [active] 877468006768 Zn binding site [ion binding]; other site 877468006769 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 877468006770 dimer interface [polypeptide binding]; other site 877468006771 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 877468006772 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 877468006773 GIY-YIG motif/motif A; other site 877468006774 active site 877468006775 catalytic site [active] 877468006776 putative DNA binding site [nucleotide binding]; other site 877468006777 metal binding site [ion binding]; metal-binding site 877468006778 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 877468006779 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 877468006780 homodimer interface [polypeptide binding]; other site 877468006781 NAD binding pocket [chemical binding]; other site 877468006782 ATP binding pocket [chemical binding]; other site 877468006783 Mg binding site [ion binding]; other site 877468006784 active-site loop [active] 877468006785 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 877468006786 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 877468006787 active site 877468006788 P-loop; other site 877468006789 phosphorylation site [posttranslational modification] 877468006790 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 877468006791 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 877468006792 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 877468006793 methionine cluster; other site 877468006794 active site 877468006795 phosphorylation site [posttranslational modification] 877468006796 metal binding site [ion binding]; metal-binding site 877468006797 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 877468006798 Cupin domain; Region: Cupin_2; pfam07883 877468006799 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 877468006800 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 877468006801 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 877468006802 NAD binding site [chemical binding]; other site 877468006803 sugar binding site [chemical binding]; other site 877468006804 divalent metal binding site [ion binding]; other site 877468006805 tetramer (dimer of dimers) interface [polypeptide binding]; other site 877468006806 dimer interface [polypeptide binding]; other site 877468006807 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 877468006808 putative active site [active] 877468006809 YdjC motif; other site 877468006810 Mg binding site [ion binding]; other site 877468006811 putative homodimer interface [polypeptide binding]; other site 877468006812 hydroperoxidase II; Provisional; Region: katE; PRK11249 877468006813 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 877468006814 tetramer interface [polypeptide binding]; other site 877468006815 heme binding pocket [chemical binding]; other site 877468006816 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 877468006817 domain interactions; other site 877468006818 cell division modulator; Provisional; Region: PRK10113 877468006819 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 877468006820 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 877468006821 inner membrane protein; Provisional; Region: PRK11648 877468006822 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 877468006823 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 877468006824 motif II; other site 877468006825 YniB-like protein; Region: YniB; pfam14002 877468006826 Phosphotransferase enzyme family; Region: APH; pfam01636 877468006827 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 877468006828 active site 877468006829 ATP binding site [chemical binding]; other site 877468006830 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 877468006831 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 877468006832 6-phosphofructokinase 2; Provisional; Region: PRK10294 877468006833 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 877468006834 putative substrate binding site [chemical binding]; other site 877468006835 putative ATP binding site [chemical binding]; other site 877468006836 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 877468006837 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528 877468006838 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 877468006839 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 877468006840 active site 877468006841 substrate binding site [chemical binding]; other site 877468006842 Mg2+ binding site [ion binding]; other site 877468006843 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 877468006844 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 877468006845 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 877468006846 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 877468006847 active site 877468006848 dimer interface [polypeptide binding]; other site 877468006849 motif 1; other site 877468006850 motif 2; other site 877468006851 motif 3; other site 877468006852 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 877468006853 anticodon binding site; other site 877468006854 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 877468006855 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 877468006856 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 877468006857 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 877468006858 23S rRNA binding site [nucleotide binding]; other site 877468006859 L21 binding site [polypeptide binding]; other site 877468006860 L13 binding site [polypeptide binding]; other site 877468006861 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 877468006862 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 877468006863 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 877468006864 dimer interface [polypeptide binding]; other site 877468006865 motif 1; other site 877468006866 active site 877468006867 motif 2; other site 877468006868 motif 3; other site 877468006869 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 877468006870 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 877468006871 putative tRNA-binding site [nucleotide binding]; other site 877468006872 B3/4 domain; Region: B3_4; pfam03483 877468006873 tRNA synthetase B5 domain; Region: B5; smart00874 877468006874 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 877468006875 dimer interface [polypeptide binding]; other site 877468006876 motif 1; other site 877468006877 motif 3; other site 877468006878 motif 2; other site 877468006879 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 877468006880 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 877468006881 IHF dimer interface [polypeptide binding]; other site 877468006882 IHF - DNA interface [nucleotide binding]; other site 877468006883 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 877468006884 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 877468006885 ABC-ATPase subunit interface; other site 877468006886 dimer interface [polypeptide binding]; other site 877468006887 putative PBP binding regions; other site 877468006888 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 877468006889 catalytic residues [active] 877468006890 dimer interface [polypeptide binding]; other site 877468006891 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 877468006892 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 877468006893 Walker A/P-loop; other site 877468006894 ATP binding site [chemical binding]; other site 877468006895 Q-loop/lid; other site 877468006896 ABC transporter signature motif; other site 877468006897 Walker B; other site 877468006898 D-loop; other site 877468006899 H-loop/switch region; other site 877468006900 NlpC/P60 family; Region: NLPC_P60; pfam00877 877468006901 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 877468006902 Uncharacterized conserved protein [Function unknown]; Region: COG0397 877468006903 hypothetical protein; Validated; Region: PRK00029 877468006904 hypothetical protein; Provisional; Region: PRK10183 877468006905 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 877468006906 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 877468006907 PEP synthetase regulatory protein; Provisional; Region: PRK05339 877468006908 phosphoenolpyruvate synthase; Validated; Region: PRK06464 877468006909 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 877468006910 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 877468006911 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 877468006912 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 877468006913 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 877468006914 acyl-activating enzyme (AAE) consensus motif; other site 877468006915 putative AMP binding site [chemical binding]; other site 877468006916 putative active site [active] 877468006917 putative CoA binding site [chemical binding]; other site 877468006918 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 877468006919 oxidoreductase; Provisional; Region: PRK10015 877468006920 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 877468006921 Electron transfer flavoprotein domain; Region: ETF; smart00893 877468006922 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 877468006923 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 877468006924 Ligand binding site [chemical binding]; other site 877468006925 Electron transfer flavoprotein domain; Region: ETF; pfam01012 877468006926 Cupin domain; Region: Cupin_2; pfam07883 877468006927 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 877468006928 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 877468006929 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 877468006930 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 877468006931 active site 877468006932 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 877468006933 Coenzyme A transferase; Region: CoA_trans; smart00882 877468006934 Coenzyme A transferase; Region: CoA_trans; cl17247 877468006935 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 877468006936 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 877468006937 active site 877468006938 catalytic residue [active] 877468006939 dimer interface [polypeptide binding]; other site 877468006940 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 877468006941 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 877468006942 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 877468006943 shikimate binding site; other site 877468006944 NAD(P) binding site [chemical binding]; other site 877468006945 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468006946 putative substrate translocation pore; other site 877468006947 Major Facilitator Superfamily; Region: MFS_1; pfam07690 877468006948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468006949 Major Facilitator Superfamily; Region: MFS_1; pfam07690 877468006950 putative substrate translocation pore; other site 877468006951 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 877468006952 putative inner membrane protein; Provisional; Region: PRK10983 877468006953 Domain of unknown function DUF20; Region: UPF0118; pfam01594 877468006954 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 877468006955 FAD binding domain; Region: FAD_binding_4; pfam01565 877468006956 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 877468006957 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 877468006958 CoenzymeA binding site [chemical binding]; other site 877468006959 subunit interaction site [polypeptide binding]; other site 877468006960 PHB binding site; other site 877468006961 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 877468006962 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 877468006963 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 877468006964 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 877468006965 putative ABC transporter; Region: ycf24; CHL00085 877468006966 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 877468006967 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 877468006968 Walker A/P-loop; other site 877468006969 ATP binding site [chemical binding]; other site 877468006970 Q-loop/lid; other site 877468006971 ABC transporter signature motif; other site 877468006972 Walker B; other site 877468006973 D-loop; other site 877468006974 H-loop/switch region; other site 877468006975 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 877468006976 FeS assembly protein SufD; Region: sufD; TIGR01981 877468006977 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 877468006978 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 877468006979 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 877468006980 catalytic residue [active] 877468006981 cysteine desufuration protein SufE; Provisional; Region: PRK09296 877468006982 L,D-transpeptidase; Provisional; Region: PRK10190 877468006983 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 877468006984 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 877468006985 murein lipoprotein; Provisional; Region: PRK15396 877468006986 pyruvate kinase; Provisional; Region: PRK09206 877468006987 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 877468006988 domain interfaces; other site 877468006989 active site 877468006990 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 877468006991 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 877468006992 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 877468006993 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 877468006994 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 877468006995 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 877468006996 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 877468006997 substrate binding site [chemical binding]; other site 877468006998 dimer interface [polypeptide binding]; other site 877468006999 ATP binding site [chemical binding]; other site 877468007000 tetrathionate reductase subunit A; Provisional; Region: PRK14991 877468007001 The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758 877468007002 putative [Fe4-S4] binding site [ion binding]; other site 877468007003 putative molybdopterin cofactor binding site [chemical binding]; other site 877468007004 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 877468007005 putative molybdopterin cofactor binding site; other site 877468007006 tetrathionate reductase subunit C; Provisional; Region: PRK14992 877468007007 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 877468007008 tetrathionate reductase subunit B; Provisional; Region: PRK14993 877468007009 4Fe-4S binding domain; Region: Fer4; pfam00037 877468007010 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 877468007011 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 877468007012 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 877468007013 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 877468007014 dimer interface [polypeptide binding]; other site 877468007015 phosphorylation site [posttranslational modification] 877468007016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 877468007017 ATP binding site [chemical binding]; other site 877468007018 Mg2+ binding site [ion binding]; other site 877468007019 G-X-G motif; other site 877468007020 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 877468007021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 877468007022 active site 877468007023 phosphorylation site [posttranslational modification] 877468007024 intermolecular recognition site; other site 877468007025 dimerization interface [polypeptide binding]; other site 877468007026 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 877468007027 DNA binding residues [nucleotide binding] 877468007028 dimerization interface [polypeptide binding]; other site 877468007029 hypothetical protein; Provisional; Region: PRK10292 877468007030 Uncharacterized conserved protein [Function unknown]; Region: COG1683 877468007031 Uncharacterized conserved protein [Function unknown]; Region: COG3272 877468007032 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 877468007033 transcriptional regulator MirA; Provisional; Region: PRK15043 877468007034 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 877468007035 DNA binding residues [nucleotide binding] 877468007036 two component system sensor kinase SsrB; Provisional; Region: PRK15369 877468007037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 877468007038 active site 877468007039 phosphorylation site [posttranslational modification] 877468007040 intermolecular recognition site; other site 877468007041 dimerization interface [polypeptide binding]; other site 877468007042 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 877468007043 DNA binding residues [nucleotide binding] 877468007044 dimerization interface [polypeptide binding]; other site 877468007045 two component system sensor kinase SsrA; Provisional; Region: PRK15347 877468007046 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 877468007047 dimerization interface [polypeptide binding]; other site 877468007048 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 877468007049 dimer interface [polypeptide binding]; other site 877468007050 phosphorylation site [posttranslational modification] 877468007051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 877468007052 ATP binding site [chemical binding]; other site 877468007053 Mg2+ binding site [ion binding]; other site 877468007054 G-X-G motif; other site 877468007055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 877468007056 active site 877468007057 phosphorylation site [posttranslational modification] 877468007058 intermolecular recognition site; other site 877468007059 dimerization interface [polypeptide binding]; other site 877468007060 outer membrane secretin SsaC; Provisional; Region: PRK15346 877468007061 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 877468007062 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 877468007063 type III secretion system protein SsaD; Provisional; Region: PRK15367 877468007064 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 877468007065 type III secretion system chaperone SsaE; Provisional; Region: PRK15366 877468007066 EspA-like secreted protein; Region: EspA; cl04069 877468007067 pathogenicity island 2 chaperone protein SscA; Provisional; Region: PRK15363 877468007068 pathogenicity island 2 effector protein SseC; Provisional; Region: PRK15362 877468007069 pathogenicity island 2 effector protein SseD; Provisional; Region: PRK15361 877468007070 pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360 877468007071 type III secretion system chaperone protein SscB; Provisional; Region: PRK15359 877468007072 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 877468007073 TPR motif; other site 877468007074 binding surface 877468007075 pathogenicity island 2 effector protein SseF; Provisional; Region: PRK15358 877468007076 pathogenicity island 2 effector protein SseG; Provisional; Region: PRK15357 877468007077 type III secretion system needle protein SsaG; Provisional; Region: PRK15344 877468007078 type III secretion system protein SsaH; Provisional; Region: PRK15356 877468007079 Type III secretion needle MxiH like; Region: MxiH; cl09641 877468007080 type III secretion system lipoprotein SsaJ; Provisional; Region: PRK15348 877468007081 Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327 877468007082 type III secretion system protein SsaK; Provisional; Region: PRK15354 877468007083 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 877468007084 type III secretion system protein SsaL; Provisional; Region: PRK15345 877468007085 HrpJ-like domain; Region: HrpJ; pfam07201 877468007086 TyeA; Region: TyeA; cl07611 877468007087 type III secretion system protein SsaM; Provisional; Region: PRK15353 877468007088 secretion system apparatus protein SsaV; Provisional; Region: PRK12720 877468007089 FHIPEP family; Region: FHIPEP; pfam00771 877468007090 type III secretion system ATPase SsaN; Validated; Region: PRK07594 877468007091 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 877468007092 Walker A motif; other site 877468007093 ATP binding site [chemical binding]; other site 877468007094 Walker B motif; other site 877468007095 type III secretion system protein SsaO; Provisional; Region: PRK15352 877468007096 type III secretion system protein SsaP; Provisional; Region: PRK15351 877468007097 type III secretion system protein SsaQ; Validated; Region: PRK08035 877468007098 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 877468007099 Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790 877468007100 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 877468007101 secretion system apparatus protein SsaU; Reviewed; Region: PRK12721 877468007102 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 877468007103 multidrug efflux protein; Reviewed; Region: PRK01766 877468007104 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 877468007105 cation binding site [ion binding]; other site 877468007106 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 877468007107 Lumazine binding domain; Region: Lum_binding; pfam00677 877468007108 Lumazine binding domain; Region: Lum_binding; pfam00677 877468007109 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 877468007110 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 877468007111 S-adenosylmethionine binding site [chemical binding]; other site 877468007112 putative transporter; Provisional; Region: PRK11043 877468007113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468007114 putative substrate translocation pore; other site 877468007115 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 877468007116 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468007117 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 877468007118 dimerization interface [polypeptide binding]; other site 877468007119 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 877468007120 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 877468007121 DNA binding site [nucleotide binding] 877468007122 domain linker motif; other site 877468007123 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 877468007124 dimerization interface [polypeptide binding]; other site 877468007125 ligand binding site [chemical binding]; other site 877468007126 superoxide dismutase; Provisional; Region: PRK10543 877468007127 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 877468007128 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 877468007129 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 877468007130 NlpC/P60 family; Region: NLPC_P60; pfam00877 877468007131 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 877468007132 putative GSH binding site [chemical binding]; other site 877468007133 catalytic residues [active] 877468007134 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 877468007135 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 877468007136 dimer interface [polypeptide binding]; other site 877468007137 catalytic site [active] 877468007138 putative active site [active] 877468007139 putative substrate binding site [chemical binding]; other site 877468007140 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 877468007141 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 877468007142 dimer interface [polypeptide binding]; other site 877468007143 active site 877468007144 metal binding site [ion binding]; metal-binding site 877468007145 glutathione binding site [chemical binding]; other site 877468007146 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 877468007147 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 877468007148 FMN binding site [chemical binding]; other site 877468007149 active site 877468007150 substrate binding site [chemical binding]; other site 877468007151 catalytic residue [active] 877468007152 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 877468007153 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 877468007154 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 877468007155 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 877468007156 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 877468007157 active site 877468007158 catalytic tetrad [active] 877468007159 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 877468007160 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 877468007161 E-class dimer interface [polypeptide binding]; other site 877468007162 P-class dimer interface [polypeptide binding]; other site 877468007163 active site 877468007164 Cu2+ binding site [ion binding]; other site 877468007165 Zn2+ binding site [ion binding]; other site 877468007166 Fusaric acid resistance protein family; Region: FUSC; pfam04632 877468007167 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 877468007168 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 877468007169 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 877468007170 HlyD family secretion protein; Region: HlyD_3; pfam13437 877468007171 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 877468007172 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 877468007173 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 877468007174 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 877468007175 lysozyme inhibitor; Provisional; Region: PRK11372 877468007176 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 877468007177 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 877468007178 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 877468007179 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 877468007180 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 877468007181 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 877468007182 active site 877468007183 HIGH motif; other site 877468007184 dimer interface [polypeptide binding]; other site 877468007185 KMSKS motif; other site 877468007186 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 877468007187 RNA binding surface [nucleotide binding]; other site 877468007188 pyridoxamine kinase; Validated; Region: PRK05756 877468007189 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 877468007190 ATP binding site [chemical binding]; other site 877468007191 glutathionine S-transferase; Provisional; Region: PRK10542 877468007192 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 877468007193 C-terminal domain interface [polypeptide binding]; other site 877468007194 GSH binding site (G-site) [chemical binding]; other site 877468007195 dimer interface [polypeptide binding]; other site 877468007196 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 877468007197 dimer interface [polypeptide binding]; other site 877468007198 N-terminal domain interface [polypeptide binding]; other site 877468007199 substrate binding pocket (H-site) [chemical binding]; other site 877468007200 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 877468007201 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468007202 putative substrate translocation pore; other site 877468007203 POT family; Region: PTR2; pfam00854 877468007204 endonuclease III; Provisional; Region: PRK10702 877468007205 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 877468007206 minor groove reading motif; other site 877468007207 helix-hairpin-helix signature motif; other site 877468007208 substrate binding pocket [chemical binding]; other site 877468007209 active site 877468007210 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 877468007211 electron transport complex RsxE subunit; Provisional; Region: PRK12405 877468007212 electron transport complex protein RnfG; Validated; Region: PRK01908 877468007213 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 877468007214 electron transport complex protein RnfC; Provisional; Region: PRK05035 877468007215 SLBB domain; Region: SLBB; pfam10531 877468007216 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 877468007217 electron transport complex protein RnfB; Provisional; Region: PRK05113 877468007218 Putative Fe-S cluster; Region: FeS; cl17515 877468007219 4Fe-4S binding domain; Region: Fer4; pfam00037 877468007220 electron transport complex protein RsxA; Provisional; Region: PRK05151 877468007221 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 877468007222 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 877468007223 putative oxidoreductase; Provisional; Region: PRK11579 877468007224 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 877468007225 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 877468007226 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 877468007227 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 877468007228 active site 877468007229 purine riboside binding site [chemical binding]; other site 877468007230 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 877468007231 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 877468007232 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 877468007233 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 877468007234 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 877468007235 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 877468007236 fumarate hydratase; Provisional; Region: PRK15389 877468007237 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 877468007238 Fumarase C-terminus; Region: Fumerase_C; pfam05683 877468007239 fumarate hydratase; Reviewed; Region: fumC; PRK00485 877468007240 Class II fumarases; Region: Fumarase_classII; cd01362 877468007241 active site 877468007242 tetramer interface [polypeptide binding]; other site 877468007243 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 877468007244 sensor protein RstB; Provisional; Region: PRK10604 877468007245 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 877468007246 dimerization interface [polypeptide binding]; other site 877468007247 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 877468007248 dimer interface [polypeptide binding]; other site 877468007249 phosphorylation site [posttranslational modification] 877468007250 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 877468007251 ATP binding site [chemical binding]; other site 877468007252 Mg2+ binding site [ion binding]; other site 877468007253 G-X-G motif; other site 877468007254 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 877468007255 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 877468007256 active site 877468007257 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 877468007258 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 877468007259 trimer interface [polypeptide binding]; other site 877468007260 eyelet of channel; other site 877468007261 Domain of unknown function (DUF1744); Region: DUF1744; pfam08490 877468007262 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 877468007263 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 877468007264 active site 877468007265 phosphorylation site [posttranslational modification] 877468007266 intermolecular recognition site; other site 877468007267 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 877468007268 DNA binding site [nucleotide binding] 877468007269 GlpM protein; Region: GlpM; pfam06942 877468007270 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 877468007271 Spore germination protein; Region: Spore_permease; cl17796 877468007272 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 877468007273 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 877468007274 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 877468007275 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 877468007276 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 877468007277 ligand binding site [chemical binding]; other site 877468007278 homodimer interface [polypeptide binding]; other site 877468007279 NAD(P) binding site [chemical binding]; other site 877468007280 trimer interface B [polypeptide binding]; other site 877468007281 trimer interface A [polypeptide binding]; other site 877468007282 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 877468007283 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 877468007284 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 877468007285 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 877468007286 Domain of unknown function DUF20; Region: UPF0118; pfam01594 877468007287 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 877468007288 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 877468007289 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 877468007290 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 877468007291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468007292 putative substrate translocation pore; other site 877468007293 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 877468007294 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468007295 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 877468007296 dimerization interface [polypeptide binding]; other site 877468007297 substrate binding pocket [chemical binding]; other site 877468007298 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 877468007299 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 877468007300 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 877468007301 putative dithiobiotin synthetase; Provisional; Region: PRK12374 877468007302 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 877468007303 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 877468007304 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 877468007305 Cl- selectivity filter; other site 877468007306 Cl- binding residues [ion binding]; other site 877468007307 pore gating glutamate residue; other site 877468007308 dimer interface [polypeptide binding]; other site 877468007309 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 877468007310 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 877468007311 Walker A/P-loop; other site 877468007312 ATP binding site [chemical binding]; other site 877468007313 Q-loop/lid; other site 877468007314 ABC transporter signature motif; other site 877468007315 Walker B; other site 877468007316 D-loop; other site 877468007317 H-loop/switch region; other site 877468007318 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 877468007319 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468007320 dimer interface [polypeptide binding]; other site 877468007321 conserved gate region; other site 877468007322 ABC-ATPase subunit interface; other site 877468007323 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 877468007324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468007325 dimer interface [polypeptide binding]; other site 877468007326 conserved gate region; other site 877468007327 putative PBP binding loops; other site 877468007328 ABC-ATPase subunit interface; other site 877468007329 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 877468007330 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 877468007331 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 877468007332 4Fe-4S binding domain; Region: Fer4; pfam00037 877468007333 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 877468007334 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 877468007335 putative [Fe4-S4] binding site [ion binding]; other site 877468007336 putative molybdopterin cofactor binding site [chemical binding]; other site 877468007337 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 877468007338 putative molybdopterin cofactor binding site; other site 877468007339 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 877468007340 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 877468007341 putative [Fe4-S4] binding site [ion binding]; other site 877468007342 putative molybdopterin cofactor binding site [chemical binding]; other site 877468007343 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 877468007344 putative molybdopterin cofactor binding site; other site 877468007345 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 877468007346 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 877468007347 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 877468007348 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 877468007349 Coenzyme A binding pocket [chemical binding]; other site 877468007350 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 877468007351 hypothetical protein; Provisional; Region: PRK13659 877468007352 hypothetical protein; Provisional; Region: PRK02237 877468007353 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 877468007354 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 877468007355 putative active site pocket [active] 877468007356 putative metal binding site [ion binding]; other site 877468007357 putative oxidoreductase; Provisional; Region: PRK10083 877468007358 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 877468007359 putative NAD(P) binding site [chemical binding]; other site 877468007360 catalytic Zn binding site [ion binding]; other site 877468007361 structural Zn binding site [ion binding]; other site 877468007362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468007363 metabolite-proton symporter; Region: 2A0106; TIGR00883 877468007364 putative substrate translocation pore; other site 877468007365 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 877468007366 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 877468007367 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 877468007368 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 877468007369 Transcriptional regulators [Transcription]; Region: GntR; COG1802 877468007370 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 877468007371 DNA-binding site [nucleotide binding]; DNA binding site 877468007372 FCD domain; Region: FCD; pfam07729 877468007373 malonic semialdehyde reductase; Provisional; Region: PRK10538 877468007374 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 877468007375 putative NAD(P) binding site [chemical binding]; other site 877468007376 homodimer interface [polypeptide binding]; other site 877468007377 homotetramer interface [polypeptide binding]; other site 877468007378 active site 877468007379 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 877468007380 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 877468007381 active site 877468007382 Zn binding site [ion binding]; other site 877468007383 General stress protein [General function prediction only]; Region: GsiB; COG3729 877468007384 hypothetical protein; Validated; Region: PRK03657 877468007385 hypothetical protein; Provisional; Region: PRK10053 877468007386 putative transporter; Provisional; Region: PRK10054 877468007387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468007388 putative substrate translocation pore; other site 877468007389 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 877468007390 EamA-like transporter family; Region: EamA; pfam00892 877468007391 MarB protein; Region: MarB; pfam13999 877468007392 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 877468007393 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 877468007394 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 877468007395 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 877468007396 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 877468007397 inner membrane protein; Provisional; Region: PRK10995 877468007398 putative arabinose transporter; Provisional; Region: PRK03545 877468007399 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468007400 putative substrate translocation pore; other site 877468007401 Transcriptional regulator [Transcription]; Region: LysR; COG0583 877468007402 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468007403 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 877468007404 putative dimerization interface [polypeptide binding]; other site 877468007405 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 877468007406 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 877468007407 NAD(P) binding site [chemical binding]; other site 877468007408 catalytic residues [active] 877468007409 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 877468007410 glutaminase; Provisional; Region: PRK00971 877468007411 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 877468007412 Predicted membrane protein [Function unknown]; Region: COG3781 877468007413 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 877468007414 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 877468007415 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 877468007416 trimer interface [polypeptide binding]; other site 877468007417 eyelet of channel; other site 877468007418 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 877468007419 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 877468007420 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 877468007421 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 877468007422 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 877468007423 Rubredoxin [Energy production and conversion]; Region: COG1773 877468007424 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 877468007425 iron binding site [ion binding]; other site 877468007426 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 877468007427 HupF/HypC family; Region: HupF_HypC; cl00394 877468007428 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 877468007429 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 877468007430 putative substrate-binding site; other site 877468007431 nickel binding site [ion binding]; other site 877468007432 Ni,Fe-hydrogenase I cytochrome b subunit [Energy production and conversion]; Region: HyaC; COG1969 877468007433 hydrogenase 1 large subunit; Provisional; Region: PRK10170 877468007434 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 877468007435 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 877468007436 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 877468007437 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 877468007438 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 877468007439 active site 877468007440 Transcriptional regulators [Transcription]; Region: FadR; COG2186 877468007441 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 877468007442 DNA-binding site [nucleotide binding]; DNA binding site 877468007443 FCD domain; Region: FCD; pfam07729 877468007444 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 877468007445 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 877468007446 putative NAD(P) binding site [chemical binding]; other site 877468007447 catalytic Zn binding site [ion binding]; other site 877468007448 structural Zn binding site [ion binding]; other site 877468007449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468007450 D-galactonate transporter; Region: 2A0114; TIGR00893 877468007451 putative substrate translocation pore; other site 877468007452 PhoPQ-activated pathogenicity-related protein [General function prediction only]; Region: PqaA; COG4287 877468007453 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 877468007454 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468007455 Major Facilitator Superfamily; Region: MFS_1; pfam07690 877468007456 putative substrate translocation pore; other site 877468007457 hypothetical protein; Provisional; Region: PRK06184 877468007458 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 877468007459 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 877468007460 Transcriptional regulators [Transcription]; Region: MarR; COG1846 877468007461 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 877468007462 putative DNA binding site [nucleotide binding]; other site 877468007463 putative Zn2+ binding site [ion binding]; other site 877468007464 S-adenosylmethionine:tRNA-ribosyltransferase- isomerase (queuine synthetase) [Translation, ribosomal structure and biogenesis]; Region: QueA; COG0809 877468007465 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 877468007466 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 877468007467 homotrimer interaction site [polypeptide binding]; other site 877468007468 putative active site [active] 877468007469 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 877468007470 Domain of unknown function DUF29; Region: DUF29; pfam01724 877468007471 Transcriptional regulator [Transcription]; Region: LysR; COG0583 877468007472 Transcriptional regulators [Transcription]; Region: PurR; COG1609 877468007473 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 877468007474 DNA binding site [nucleotide binding] 877468007475 domain linker motif; other site 877468007476 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 877468007477 dimerization interface (closed form) [polypeptide binding]; other site 877468007478 ligand binding site [chemical binding]; other site 877468007479 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 877468007480 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 877468007481 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 877468007482 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468007483 homodimer interface [polypeptide binding]; other site 877468007484 catalytic residue [active] 877468007485 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 877468007486 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 877468007487 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 877468007488 active site 877468007489 catalytic site [active] 877468007490 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 877468007491 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 877468007492 active site 877468007493 catalytic site [active] 877468007494 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 877468007495 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 877468007496 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 877468007497 catalytic site [active] 877468007498 active site 877468007499 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 877468007500 Protein of unknown function (DUF1264); Region: DUF1264; pfam06884 877468007501 acid-resistance protein; Provisional; Region: hdeB; PRK11566 877468007502 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 877468007503 biofilm-dependent modulation protein; Provisional; Region: PRK11436 877468007504 malate dehydrogenase; Provisional; Region: PRK13529 877468007505 Malic enzyme, N-terminal domain; Region: malic; pfam00390 877468007506 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 877468007507 NAD(P) binding site [chemical binding]; other site 877468007508 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 877468007509 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 877468007510 NAD binding site [chemical binding]; other site 877468007511 substrate binding site [chemical binding]; other site 877468007512 catalytic Zn binding site [ion binding]; other site 877468007513 tetramer interface [polypeptide binding]; other site 877468007514 structural Zn binding site [ion binding]; other site 877468007515 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 877468007516 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 877468007517 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 877468007518 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 877468007519 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 877468007520 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 877468007521 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 877468007522 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 877468007523 molybdopterin cofactor binding site; other site 877468007524 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 877468007525 aromatic amino acid exporter; Provisional; Region: PRK11689 877468007526 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 877468007527 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 877468007528 trimer interface [polypeptide binding]; other site 877468007529 eyelet of channel; other site 877468007530 Uncharacterized conserved protein [Function unknown]; Region: COG3791 877468007531 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 877468007532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468007533 putative substrate translocation pore; other site 877468007534 TetR family transcriptional regulator; Provisional; Region: PRK14996 877468007535 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 877468007536 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 877468007537 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 877468007538 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 877468007539 [4Fe-4S] binding site [ion binding]; other site 877468007540 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 877468007541 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 877468007542 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 877468007543 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 877468007544 molybdopterin cofactor binding site; other site 877468007545 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 877468007546 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 877468007547 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 877468007548 hypothetical protein; Provisional; Region: PRK10281 877468007549 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 877468007550 L-asparagine permease; Provisional; Region: PRK15049 877468007551 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 877468007552 Uncharacterized conserved protein [Function unknown]; Region: COG3391 877468007553 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 877468007554 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 877468007555 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 877468007556 N-terminal plug; other site 877468007557 ligand-binding site [chemical binding]; other site 877468007558 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 877468007559 DNA-binding site [nucleotide binding]; DNA binding site 877468007560 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 877468007561 FCD domain; Region: FCD; pfam07729 877468007562 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 877468007563 Prostaglandin dehydrogenases; Region: PGDH; cd05288 877468007564 NAD(P) binding site [chemical binding]; other site 877468007565 substrate binding site [chemical binding]; other site 877468007566 dimer interface [polypeptide binding]; other site 877468007567 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 877468007568 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 877468007569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 877468007570 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 877468007571 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfB; COG4457 877468007572 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458 877468007573 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 877468007574 1-pyrroline dehydrogenase; Region: ABALDH; TIGR03374 877468007575 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 877468007576 tetrameric interface [polypeptide binding]; other site 877468007577 NAD binding site [chemical binding]; other site 877468007578 catalytic residues [active] 877468007579 substrate binding site [chemical binding]; other site 877468007580 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 877468007581 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 877468007582 DNA-binding site [nucleotide binding]; DNA binding site 877468007583 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 877468007584 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468007585 homodimer interface [polypeptide binding]; other site 877468007586 catalytic residue [active] 877468007587 D-alanyl-D-alanine dipeptidase [Cell envelope biogenesis, outer membrane]; Region: DdpX; COG2173 877468007588 secreted effector protein SifB; Provisional; Region: sifB; PRK09499 877468007589 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 877468007590 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 877468007591 Peptidase family U32; Region: Peptidase_U32; pfam01136 877468007592 Collagenase; Region: DUF3656; pfam12392 877468007593 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 877468007594 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 877468007595 non-specific DNA binding site [nucleotide binding]; other site 877468007596 salt bridge; other site 877468007597 sequence-specific DNA binding site [nucleotide binding]; other site 877468007598 Cupin domain; Region: Cupin_2; pfam07883 877468007599 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 877468007600 benzoate transporter; Region: benE; TIGR00843 877468007601 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 877468007602 tellurite resistance protein TehB; Provisional; Region: PRK11207 877468007603 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 877468007604 S-adenosylmethionine binding site [chemical binding]; other site 877468007605 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 877468007606 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 877468007607 gating phenylalanine in ion channel; other site 877468007608 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 877468007609 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 877468007610 putative trimer interface [polypeptide binding]; other site 877468007611 putative CoA binding site [chemical binding]; other site 877468007612 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 877468007613 putative trimer interface [polypeptide binding]; other site 877468007614 putative CoA binding site [chemical binding]; other site 877468007615 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 877468007616 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 877468007617 Coenzyme A binding pocket [chemical binding]; other site 877468007618 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 877468007619 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 877468007620 oligomer interface [polypeptide binding]; other site 877468007621 active site 877468007622 metal binding site [ion binding]; metal-binding site 877468007623 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 877468007624 active site 877468007625 P-loop; other site 877468007626 phosphorylation site [posttranslational modification] 877468007627 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 877468007628 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 877468007629 membrane complex biogenesis protein, BtpA family; Region: thylakoid_BtpA; TIGR00259 877468007630 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 877468007631 active site 877468007632 phosphorylation site [posttranslational modification] 877468007633 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 877468007634 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 877468007635 substrate binding site [chemical binding]; other site 877468007636 hexamer interface [polypeptide binding]; other site 877468007637 metal binding site [ion binding]; metal-binding site 877468007638 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 877468007639 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 877468007640 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 877468007641 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 877468007642 Coenzyme A binding pocket [chemical binding]; other site 877468007643 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 877468007644 teramer interface [polypeptide binding]; other site 877468007645 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 877468007646 active site 877468007647 FMN binding site [chemical binding]; other site 877468007648 catalytic residues [active] 877468007649 Uncharacterized conserved protein [Function unknown]; Region: COG2353 877468007650 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 877468007651 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 877468007652 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 877468007653 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 877468007654 substrate binding pocket [chemical binding]; other site 877468007655 catalytic triad [active] 877468007656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 877468007657 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 877468007658 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 877468007659 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468007660 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 877468007661 dimerization interface [polypeptide binding]; other site 877468007662 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 877468007663 dimer interface [polypeptide binding]; other site 877468007664 ligand binding site [chemical binding]; other site 877468007665 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 877468007666 HAMP domain; Region: HAMP; pfam00672 877468007667 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 877468007668 dimer interface [polypeptide binding]; other site 877468007669 putative CheW interface [polypeptide binding]; other site 877468007670 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 877468007671 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 877468007672 substrate binding site [chemical binding]; other site 877468007673 catalytic Zn binding site [ion binding]; other site 877468007674 NAD binding site [chemical binding]; other site 877468007675 structural Zn binding site [ion binding]; other site 877468007676 dimer interface [polypeptide binding]; other site 877468007677 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 877468007678 putative metal binding site [ion binding]; other site 877468007679 putative homodimer interface [polypeptide binding]; other site 877468007680 putative homotetramer interface [polypeptide binding]; other site 877468007681 putative homodimer-homodimer interface [polypeptide binding]; other site 877468007682 putative allosteric switch controlling residues; other site 877468007683 Sif protein; Region: Sif; cl11505 877468007684 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 877468007685 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 877468007686 active site 877468007687 catalytic triad [active] 877468007688 oxyanion hole [active] 877468007689 Predicted membrane protein [Function unknown]; Region: COG3326 877468007690 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 877468007691 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 877468007692 substrate binding pocket [chemical binding]; other site 877468007693 membrane-bound complex binding site; other site 877468007694 hinge residues; other site 877468007695 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 877468007696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468007697 dimer interface [polypeptide binding]; other site 877468007698 conserved gate region; other site 877468007699 putative PBP binding loops; other site 877468007700 ABC-ATPase subunit interface; other site 877468007701 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 877468007702 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 877468007703 Walker A/P-loop; other site 877468007704 ATP binding site [chemical binding]; other site 877468007705 Q-loop/lid; other site 877468007706 ABC transporter signature motif; other site 877468007707 Walker B; other site 877468007708 D-loop; other site 877468007709 H-loop/switch region; other site 877468007710 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 877468007711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468007712 dimer interface [polypeptide binding]; other site 877468007713 conserved gate region; other site 877468007714 putative PBP binding loops; other site 877468007715 ABC-ATPase subunit interface; other site 877468007716 Predicted membrane protein [Function unknown]; Region: COG5305 877468007717 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 877468007718 S-adenosylmethionine binding site [chemical binding]; other site 877468007719 cytochrome b561; Provisional; Region: PRK11513 877468007720 Uncharacterized conserved protein [Function unknown]; Region: COG1434 877468007721 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 877468007722 putative active site [active] 877468007723 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 877468007724 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 877468007725 ATP binding site [chemical binding]; other site 877468007726 putative Mg++ binding site [ion binding]; other site 877468007727 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 877468007728 nucleotide binding region [chemical binding]; other site 877468007729 ATP-binding site [chemical binding]; other site 877468007730 Helicase associated domain (HA2); Region: HA2; pfam04408 877468007731 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 877468007732 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 877468007733 azoreductase; Reviewed; Region: PRK00170 877468007734 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 877468007735 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 877468007736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 877468007737 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 877468007738 hypothetical protein; Provisional; Region: PRK10695 877468007739 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 877468007740 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 877468007741 putative ligand binding site [chemical binding]; other site 877468007742 putative NAD binding site [chemical binding]; other site 877468007743 catalytic site [active] 877468007744 heat-inducible protein; Provisional; Region: PRK10449 877468007745 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 877468007746 Domain of unknown function (DUF333); Region: DUF333; pfam03891 877468007747 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 877468007748 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 877468007749 dimer interface [polypeptide binding]; other site 877468007750 PYR/PP interface [polypeptide binding]; other site 877468007751 TPP binding site [chemical binding]; other site 877468007752 substrate binding site [chemical binding]; other site 877468007753 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 877468007754 Domain of unknown function; Region: EKR; smart00890 877468007755 4Fe-4S binding domain; Region: Fer4_6; pfam12837 877468007756 4Fe-4S binding domain; Region: Fer4; pfam00037 877468007757 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 877468007758 TPP-binding site [chemical binding]; other site 877468007759 dimer interface [polypeptide binding]; other site 877468007760 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 877468007761 Ligand Binding Site [chemical binding]; other site 877468007762 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 877468007763 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 877468007764 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 877468007765 Ligand Binding Site [chemical binding]; other site 877468007766 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 877468007767 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 877468007768 ATP binding site [chemical binding]; other site 877468007769 Mg++ binding site [ion binding]; other site 877468007770 motif III; other site 877468007771 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 877468007772 nucleotide binding region [chemical binding]; other site 877468007773 ATP-binding site [chemical binding]; other site 877468007774 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 877468007775 putative RNA binding site [nucleotide binding]; other site 877468007776 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 877468007777 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 877468007778 Cl binding site [ion binding]; other site 877468007779 oligomer interface [polypeptide binding]; other site 877468007780 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 877468007781 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 877468007782 dimer interface [polypeptide binding]; other site 877468007783 putative CheW interface [polypeptide binding]; other site 877468007784 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 877468007785 Smr domain; Region: Smr; pfam01713 877468007786 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 877468007787 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 877468007788 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 877468007789 DNA binding site [nucleotide binding] 877468007790 active site 877468007791 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 877468007792 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 877468007793 ligand binding site [chemical binding]; other site 877468007794 flexible hinge region; other site 877468007795 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 877468007796 putative switch regulator; other site 877468007797 non-specific DNA interactions [nucleotide binding]; other site 877468007798 DNA binding site [nucleotide binding] 877468007799 sequence specific DNA binding site [nucleotide binding]; other site 877468007800 putative cAMP binding site [chemical binding]; other site 877468007801 universal stress protein UspE; Provisional; Region: PRK11175 877468007802 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 877468007803 Ligand Binding Site [chemical binding]; other site 877468007804 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 877468007805 Ligand Binding Site [chemical binding]; other site 877468007806 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 877468007807 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 877468007808 Mechanosensitive ion channel; Region: MS_channel; pfam00924 877468007809 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 877468007810 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 877468007811 non-specific DNA binding site [nucleotide binding]; other site 877468007812 salt bridge; other site 877468007813 sequence-specific DNA binding site [nucleotide binding]; other site 877468007814 Cupin domain; Region: Cupin_2; pfam07883 877468007815 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 877468007816 B3/4 domain; Region: B3_4; pfam03483 877468007817 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: Tpx; COG2077 877468007818 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 877468007819 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 877468007820 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 877468007821 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 877468007822 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 877468007823 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 877468007824 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 877468007825 oxidoreductase; Provisional; Region: PRK12742 877468007826 classical (c) SDRs; Region: SDR_c; cd05233 877468007827 NAD(P) binding site [chemical binding]; other site 877468007828 active site 877468007829 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 877468007830 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 877468007831 active site 877468007832 catalytic tetrad [active] 877468007833 Transcriptional regulator [Transcription]; Region: LysR; COG0583 877468007834 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468007835 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 877468007836 putative effector binding pocket; other site 877468007837 putative dimerization interface [polypeptide binding]; other site 877468007838 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 877468007839 NmrA-like family; Region: NmrA; pfam05368 877468007840 NAD(P) binding site [chemical binding]; other site 877468007841 active site lysine 877468007842 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 877468007843 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 877468007844 peptide binding site [polypeptide binding]; other site 877468007845 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 877468007846 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 877468007847 putative active site [active] 877468007848 Zn binding site [ion binding]; other site 877468007849 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 877468007850 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 877468007851 active site 877468007852 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 877468007853 dimer interface [polypeptide binding]; other site 877468007854 catalytic triad [active] 877468007855 peroxidatic and resolving cysteines [active] 877468007856 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 877468007857 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 877468007858 putative aromatic amino acid binding site; other site 877468007859 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 877468007860 Walker A motif; other site 877468007861 ATP binding site [chemical binding]; other site 877468007862 Walker B motif; other site 877468007863 arginine finger; other site 877468007864 hypothetical protein; Provisional; Region: PRK05415 877468007865 TIGR01620 family protein; Region: hyp_HI0043 877468007866 Predicted ATPase [General function prediction only]; Region: COG3106 877468007867 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 877468007868 active site residue [active] 877468007869 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 877468007870 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 877468007871 phage shock protein C; Region: phageshock_pspC; TIGR02978 877468007872 phage shock protein B; Provisional; Region: pspB; PRK09458 877468007873 phage shock protein PspA; Provisional; Region: PRK10698 877468007874 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 877468007875 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 877468007876 Walker A motif; other site 877468007877 ATP binding site [chemical binding]; other site 877468007878 Walker B motif; other site 877468007879 arginine finger; other site 877468007880 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 877468007881 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 877468007882 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 877468007883 peptide binding site [polypeptide binding]; other site 877468007884 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 877468007885 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468007886 dimer interface [polypeptide binding]; other site 877468007887 conserved gate region; other site 877468007888 putative PBP binding loops; other site 877468007889 ABC-ATPase subunit interface; other site 877468007890 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 877468007891 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 877468007892 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468007893 dimer interface [polypeptide binding]; other site 877468007894 conserved gate region; other site 877468007895 putative PBP binding loops; other site 877468007896 ABC-ATPase subunit interface; other site 877468007897 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 877468007898 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 877468007899 Walker A/P-loop; other site 877468007900 ATP binding site [chemical binding]; other site 877468007901 Q-loop/lid; other site 877468007902 ABC transporter signature motif; other site 877468007903 Walker B; other site 877468007904 D-loop; other site 877468007905 H-loop/switch region; other site 877468007906 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 877468007907 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 877468007908 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 877468007909 Walker A/P-loop; other site 877468007910 ATP binding site [chemical binding]; other site 877468007911 Q-loop/lid; other site 877468007912 ABC transporter signature motif; other site 877468007913 Walker B; other site 877468007914 D-loop; other site 877468007915 H-loop/switch region; other site 877468007916 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 877468007917 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 877468007918 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 877468007919 NAD binding site [chemical binding]; other site 877468007920 homotetramer interface [polypeptide binding]; other site 877468007921 homodimer interface [polypeptide binding]; other site 877468007922 substrate binding site [chemical binding]; other site 877468007923 active site 877468007924 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 877468007925 Uncharacterized conserved protein [Function unknown]; Region: COG2128 877468007926 exoribonuclease II; Provisional; Region: PRK05054 877468007927 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 877468007928 RNB domain; Region: RNB; pfam00773 877468007929 S1 RNA binding domain; Region: S1; pfam00575 877468007930 RNase II stability modulator; Provisional; Region: PRK10060 877468007931 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 877468007932 putative active site [active] 877468007933 heme pocket [chemical binding]; other site 877468007934 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 877468007935 metal binding site [ion binding]; metal-binding site 877468007936 active site 877468007937 I-site; other site 877468007938 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 877468007939 hypothetical protein; Provisional; Region: PRK13658 877468007940 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 877468007941 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 877468007942 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 877468007943 lipoprotein; Provisional; Region: PRK10540 877468007944 translation initiation factor Sui1; Validated; Region: PRK06824 877468007945 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 877468007946 putative rRNA binding site [nucleotide binding]; other site 877468007947 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 877468007948 active site 877468007949 dimer interface [polypeptide binding]; other site 877468007950 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 877468007951 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 877468007952 binding surface 877468007953 TPR motif; other site 877468007954 Predicted membrane protein [Function unknown]; Region: COG3771 877468007955 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 877468007956 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 877468007957 active site 877468007958 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 877468007959 dimerization interface [polypeptide binding]; other site 877468007960 active site 877468007961 aconitate hydratase; Validated; Region: PRK09277 877468007962 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 877468007963 substrate binding site [chemical binding]; other site 877468007964 ligand binding site [chemical binding]; other site 877468007965 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 877468007966 substrate binding site [chemical binding]; other site 877468007967 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 877468007968 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468007969 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 877468007970 substrate binding site [chemical binding]; other site 877468007971 putative dimerization interface [polypeptide binding]; other site 877468007972 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 877468007973 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 877468007974 active site 877468007975 interdomain interaction site; other site 877468007976 putative metal-binding site [ion binding]; other site 877468007977 nucleotide binding site [chemical binding]; other site 877468007978 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 877468007979 domain I; other site 877468007980 DNA binding groove [nucleotide binding] 877468007981 phosphate binding site [ion binding]; other site 877468007982 domain II; other site 877468007983 domain III; other site 877468007984 nucleotide binding site [chemical binding]; other site 877468007985 catalytic site [active] 877468007986 domain IV; other site 877468007987 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 877468007988 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 877468007989 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 877468007990 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 877468007991 hypothetical protein; Provisional; Region: PRK11037 877468007992 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 877468007993 putative inner membrane peptidase; Provisional; Region: PRK11778 877468007994 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 877468007995 tandem repeat interface [polypeptide binding]; other site 877468007996 oligomer interface [polypeptide binding]; other site 877468007997 active site residues [active] 877468007998 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 877468007999 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 877468008000 NADP binding site [chemical binding]; other site 877468008001 homodimer interface [polypeptide binding]; other site 877468008002 active site 877468008003 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 877468008004 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 877468008005 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 877468008006 homodimer interface [polypeptide binding]; other site 877468008007 Walker A motif; other site 877468008008 ATP binding site [chemical binding]; other site 877468008009 hydroxycobalamin binding site [chemical binding]; other site 877468008010 Walker B motif; other site 877468008011 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 877468008012 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 877468008013 RNA binding surface [nucleotide binding]; other site 877468008014 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 877468008015 probable active site [active] 877468008016 hypothetical protein; Provisional; Region: PRK11630 877468008017 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 877468008018 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 877468008019 active site 877468008020 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 877468008021 anthranilate synthase component I; Provisional; Region: PRK13564 877468008022 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 877468008023 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 877468008024 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 877468008025 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 877468008026 glutamine binding [chemical binding]; other site 877468008027 catalytic triad [active] 877468008028 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 877468008029 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 877468008030 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 877468008031 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 877468008032 active site 877468008033 ribulose/triose binding site [chemical binding]; other site 877468008034 phosphate binding site [ion binding]; other site 877468008035 substrate (anthranilate) binding pocket [chemical binding]; other site 877468008036 product (indole) binding pocket [chemical binding]; other site 877468008037 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 877468008038 active site 877468008039 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 877468008040 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 877468008041 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468008042 catalytic residue [active] 877468008043 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 877468008044 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 877468008045 substrate binding site [chemical binding]; other site 877468008046 active site 877468008047 catalytic residues [active] 877468008048 heterodimer interface [polypeptide binding]; other site 877468008049 General stress protein [General function prediction only]; Region: GsiB; COG3729 877468008050 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 877468008051 dimerization interface [polypeptide binding]; other site 877468008052 metal binding site [ion binding]; metal-binding site 877468008053 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 877468008054 dinuclear metal binding motif [ion binding]; other site 877468008055 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 877468008056 dimanganese center [ion binding]; other site 877468008057 outer membrane protein W; Provisional; Region: PRK10959 877468008058 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 877468008059 hypothetical protein; Provisional; Region: PRK02868 877468008060 intracellular septation protein A; Reviewed; Region: PRK00259 877468008061 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 877468008062 transport protein TonB; Provisional; Region: PRK10819 877468008063 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 877468008064 YciI-like protein; Reviewed; Region: PRK11370 877468008065 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 877468008066 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 877468008067 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 877468008068 putative active site [active] 877468008069 catalytic site [active] 877468008070 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 877468008071 putative active site [active] 877468008072 catalytic site [active] 877468008073 dsDNA-mimic protein; Reviewed; Region: PRK05094 877468008074 Ion transport protein; Region: Ion_trans; pfam00520 877468008075 Ion channel; Region: Ion_trans_2; pfam07885 877468008076 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 877468008077 Double zinc ribbon; Region: DZR; pfam12773 877468008078 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 877468008079 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 877468008080 Walker A/P-loop; other site 877468008081 ATP binding site [chemical binding]; other site 877468008082 Q-loop/lid; other site 877468008083 ABC transporter signature motif; other site 877468008084 Walker B; other site 877468008085 D-loop; other site 877468008086 H-loop/switch region; other site 877468008087 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 877468008088 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 877468008089 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 877468008090 Walker A/P-loop; other site 877468008091 ATP binding site [chemical binding]; other site 877468008092 Q-loop/lid; other site 877468008093 ABC transporter signature motif; other site 877468008094 Walker B; other site 877468008095 D-loop; other site 877468008096 H-loop/switch region; other site 877468008097 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 877468008098 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 877468008099 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 877468008100 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468008101 dimer interface [polypeptide binding]; other site 877468008102 conserved gate region; other site 877468008103 ABC-ATPase subunit interface; other site 877468008104 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 877468008105 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468008106 dimer interface [polypeptide binding]; other site 877468008107 conserved gate region; other site 877468008108 putative PBP binding loops; other site 877468008109 ABC-ATPase subunit interface; other site 877468008110 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 877468008111 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 877468008112 peptide binding site [polypeptide binding]; other site 877468008113 hypothetical protein; Provisional; Region: PRK11111 877468008114 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 877468008115 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 877468008116 putative catalytic cysteine [active] 877468008117 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 877468008118 putative active site [active] 877468008119 metal binding site [ion binding]; metal-binding site 877468008120 thymidine kinase; Provisional; Region: PRK04296 877468008121 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 877468008122 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 877468008123 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 877468008124 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 877468008125 active site 877468008126 tetramer interface; other site 877468008127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 877468008128 active site 877468008129 response regulator of RpoS; Provisional; Region: PRK10693 877468008130 phosphorylation site [posttranslational modification] 877468008131 intermolecular recognition site; other site 877468008132 dimerization interface [polypeptide binding]; other site 877468008133 hypothetical protein; Provisional; Region: PRK10279 877468008134 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 877468008135 active site 877468008136 nucleophile elbow; other site 877468008137 hypothetical protein; Provisional; Region: PRK01617 877468008138 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 877468008139 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 877468008140 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 877468008141 putative active site [active] 877468008142 putative substrate binding site [chemical binding]; other site 877468008143 putative cosubstrate binding site; other site 877468008144 catalytic site [active] 877468008145 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 877468008146 Sel1-like repeats; Region: SEL1; smart00671 877468008147 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 877468008148 Sel1-like repeats; Region: SEL1; smart00671 877468008149 Sel1-like repeats; Region: SEL1; smart00671 877468008150 Sel1-like repeats; Region: SEL1; smart00671 877468008151 Sel1-like repeats; Region: SEL1; smart00671 877468008152 Sel1-like repeats; Region: SEL1; smart00671 877468008153 Sel1-like repeats; Region: SEL1; smart00671 877468008154 Sel1-like repeats; Region: SEL1; smart00671 877468008155 Sel1-like repeats; Region: SEL1; smart00671 877468008156 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 877468008157 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 877468008158 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 877468008159 4Fe-4S binding domain; Region: Fer4; cl02805 877468008160 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 877468008161 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 877468008162 [4Fe-4S] binding site [ion binding]; other site 877468008163 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 877468008164 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 877468008165 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 877468008166 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 877468008167 molybdopterin cofactor binding site; other site 877468008168 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 877468008169 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 877468008170 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 877468008171 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 877468008172 dimerization interface [polypeptide binding]; other site 877468008173 Histidine kinase; Region: HisKA_3; pfam07730 877468008174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 877468008175 ATP binding site [chemical binding]; other site 877468008176 Mg2+ binding site [ion binding]; other site 877468008177 G-X-G motif; other site 877468008178 transcriptional regulator NarL; Provisional; Region: PRK10651 877468008179 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 877468008180 active site 877468008181 phosphorylation site [posttranslational modification] 877468008182 intermolecular recognition site; other site 877468008183 dimerization interface [polypeptide binding]; other site 877468008184 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 877468008185 DNA binding residues [nucleotide binding] 877468008186 dimerization interface [polypeptide binding]; other site 877468008187 putative invasin; Provisional; Region: PRK10177 877468008188 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 877468008189 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 877468008190 cation transport regulator; Reviewed; Region: chaB; PRK09582 877468008191 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 877468008192 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 877468008193 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 877468008194 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 877468008195 hypothetical protein; Provisional; Region: PRK10941 877468008196 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 877468008197 hypothetical protein; Provisional; Region: PRK10278 877468008198 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 877468008199 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 877468008200 peptide chain release factor 1; Validated; Region: prfA; PRK00591 877468008201 This domain is found in peptide chain release factors; Region: PCRF; smart00937 877468008202 RF-1 domain; Region: RF-1; pfam00472 877468008203 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 877468008204 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 877468008205 tRNA; other site 877468008206 putative tRNA binding site [nucleotide binding]; other site 877468008207 putative NADP binding site [chemical binding]; other site 877468008208 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 877468008209 Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017 877468008210 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 877468008211 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 877468008212 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 877468008213 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 877468008214 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 877468008215 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 877468008216 active site 877468008217 putative transporter; Provisional; Region: PRK11660 877468008218 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 877468008219 Sulfate transporter family; Region: Sulfate_transp; pfam00916 877468008220 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 877468008221 hypothetical protein; Provisional; Region: PRK10692 877468008222 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 877468008223 putative active site [active] 877468008224 catalytic residue [active] 877468008225 GTP-binding protein YchF; Reviewed; Region: PRK09601 877468008226 YchF GTPase; Region: YchF; cd01900 877468008227 G1 box; other site 877468008228 GTP/Mg2+ binding site [chemical binding]; other site 877468008229 Switch I region; other site 877468008230 G2 box; other site 877468008231 Switch II region; other site 877468008232 G3 box; other site 877468008233 G4 box; other site 877468008234 G5 box; other site 877468008235 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 877468008236 Protein of unknown function (DUF2743); Region: DUF2743; pfam10899 877468008237 Protein of unknown function (DUF4427); Region: DUF4427; pfam14468 877468008238 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 877468008239 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 877468008240 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 877468008241 hydrogenase 1 large subunit; Provisional; Region: PRK10170 877468008242 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 877468008243 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 877468008244 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 877468008245 putative substrate-binding site; other site 877468008246 nickel binding site [ion binding]; other site 877468008247 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 877468008248 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 877468008249 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 877468008250 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 877468008251 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 877468008252 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 877468008253 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 877468008254 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 877468008255 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 877468008256 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 877468008257 NAD(P) binding site [chemical binding]; other site 877468008258 trehalase; Provisional; Region: treA; PRK13271 877468008259 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 877468008260 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 877468008261 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 877468008262 Flagellar regulator YcgR; Region: YcgR; pfam07317 877468008263 PilZ domain; Region: PilZ; pfam07238 877468008264 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 877468008265 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 877468008266 N-acetyl-D-glucosamine binding site [chemical binding]; other site 877468008267 catalytic residue [active] 877468008268 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 877468008269 dimer interface [polypeptide binding]; other site 877468008270 catalytic triad [active] 877468008271 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 877468008272 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 877468008273 TrkA-C domain; Region: TrkA_C; pfam02080 877468008274 Transporter associated domain; Region: CorC_HlyC; smart01091 877468008275 alanine racemase; Reviewed; Region: dadX; PRK03646 877468008276 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 877468008277 active site 877468008278 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 877468008279 substrate binding site [chemical binding]; other site 877468008280 catalytic residues [active] 877468008281 dimer interface [polypeptide binding]; other site 877468008282 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 877468008283 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 877468008284 SpoVR family protein; Provisional; Region: PRK11767 877468008285 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 877468008286 fatty acid metabolism regulator; Provisional; Region: PRK04984 877468008287 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 877468008288 DNA-binding site [nucleotide binding]; DNA binding site 877468008289 FadR C-terminal domain; Region: FadR_C; pfam07840 877468008290 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 877468008291 transmembrane helices; other site 877468008292 disulfide bond formation protein B; Provisional; Region: PRK01749 877468008293 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 877468008294 GnsA/GnsB family; Region: GnsAB; pfam08178 877468008295 hypothetical protein; Provisional; Region: PRK05170 877468008296 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 877468008297 hypothetical protein; Provisional; Region: PRK10691 877468008298 YcgL domain; Region: YcgL; cl01189 877468008299 septum formation inhibitor; Reviewed; Region: minC; PRK03511 877468008300 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 877468008301 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 877468008302 cell division inhibitor MinD; Provisional; Region: PRK10818 877468008303 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 877468008304 Switch I; other site 877468008305 Switch II; other site 877468008306 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 877468008307 ribonuclease D; Provisional; Region: PRK10829 877468008308 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 877468008309 catalytic site [active] 877468008310 putative active site [active] 877468008311 putative substrate binding site [chemical binding]; other site 877468008312 HRDC domain; Region: HRDC; cl02578 877468008313 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 877468008314 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 877468008315 acyl-activating enzyme (AAE) consensus motif; other site 877468008316 putative AMP binding site [chemical binding]; other site 877468008317 putative active site [active] 877468008318 putative CoA binding site [chemical binding]; other site 877468008319 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 877468008320 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 877468008321 Glycoprotease family; Region: Peptidase_M22; pfam00814 877468008322 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 877468008323 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 877468008324 DEAD_2; Region: DEAD_2; pfam06733 877468008325 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 877468008326 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 877468008327 homotrimer interaction site [polypeptide binding]; other site 877468008328 putative active site [active] 877468008329 hypothetical protein; Provisional; Region: PRK05114 877468008330 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 877468008331 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 877468008332 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 877468008333 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 877468008334 putative active site [active] 877468008335 putative CoA binding site [chemical binding]; other site 877468008336 nudix motif; other site 877468008337 metal binding site [ion binding]; metal-binding site 877468008338 L-serine deaminase; Provisional; Region: PRK15023 877468008339 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 877468008340 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 877468008341 phage resistance protein; Provisional; Region: PRK10551 877468008342 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 877468008343 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 877468008344 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 877468008345 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 877468008346 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 877468008347 Transporter associated domain; Region: CorC_HlyC; smart01091 877468008348 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 877468008349 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 877468008350 active pocket/dimerization site; other site 877468008351 active site 877468008352 phosphorylation site [posttranslational modification] 877468008353 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 877468008354 active site 877468008355 phosphorylation site [posttranslational modification] 877468008356 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 877468008357 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 877468008358 hypothetical protein; Provisional; Region: PRK02913 877468008359 hypothetical protein; Provisional; Region: PRK11469 877468008360 Domain of unknown function DUF; Region: DUF204; pfam02659 877468008361 Domain of unknown function DUF; Region: DUF204; pfam02659 877468008362 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 877468008363 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 877468008364 S-adenosylmethionine binding site [chemical binding]; other site 877468008365 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 877468008366 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 877468008367 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 877468008368 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 877468008369 DNA-binding site [nucleotide binding]; DNA binding site 877468008370 RNA-binding motif; other site 877468008371 YebO-like protein; Region: YebO; pfam13974 877468008372 PhoPQ regulatory protein; Provisional; Region: PRK10299 877468008373 YobH-like protein; Region: YobH; pfam13996 877468008374 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 877468008375 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 877468008376 dimerization interface [polypeptide binding]; other site 877468008377 putative Zn2+ binding site [ion binding]; other site 877468008378 putative DNA binding site [nucleotide binding]; other site 877468008379 Bacterial transcriptional regulator; Region: IclR; pfam01614 877468008380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468008381 Major Facilitator Superfamily; Region: MFS_1; pfam07690 877468008382 putative substrate translocation pore; other site 877468008383 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468008384 heat shock protein HtpX; Provisional; Region: PRK05457 877468008385 carboxy-terminal protease; Provisional; Region: PRK11186 877468008386 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 877468008387 protein binding site [polypeptide binding]; other site 877468008388 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 877468008389 Catalytic dyad [active] 877468008390 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 877468008391 ProP expression regulator; Provisional; Region: PRK04950 877468008392 ProQ/FINO family; Region: ProQ; pfam04352 877468008393 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 877468008394 GAF domain; Region: GAF_2; pfam13185 877468008395 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 877468008396 Paraquat-inducible protein A; Region: PqiA; pfam04403 877468008397 Paraquat-inducible protein A; Region: PqiA; pfam04403 877468008398 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 877468008399 mce related protein; Region: MCE; pfam02470 877468008400 mce related protein; Region: MCE; pfam02470 877468008401 mce related protein; Region: MCE; pfam02470 877468008402 mce related protein; Region: MCE; pfam02470 877468008403 mce related protein; Region: MCE; pfam02470 877468008404 mce related protein; Region: MCE; pfam02470 877468008405 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 877468008406 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 877468008407 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 877468008408 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 877468008409 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 877468008410 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 877468008411 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 877468008412 type III secretion protein SopE2; Provisional; Region: PRK15280 877468008413 SopE GEF domain; Region: SopE_GEF; pfam07487 877468008414 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 877468008415 PapC N-terminal domain; Region: PapC_N; pfam13954 877468008416 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 877468008417 Acyltransferase family; Region: Acyl_transf_3; pfam01757 877468008418 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 877468008419 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 877468008420 DNA binding site [nucleotide binding] 877468008421 Int/Topo IB signature motif; other site 877468008422 active site 877468008423 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 877468008424 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 877468008425 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 877468008426 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 877468008427 MULE transposase domain; Region: MULE; pfam10551 877468008428 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 877468008429 DNA binding site [nucleotide binding] 877468008430 active site 877468008431 Int/Topo IB signature motif; other site 877468008432 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 877468008433 EamA-like transporter family; Region: EamA; pfam00892 877468008434 EamA-like transporter family; Region: EamA; pfam00892 877468008435 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 877468008436 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 877468008437 ADP-ribose binding site [chemical binding]; other site 877468008438 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 877468008439 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 877468008440 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 877468008441 exonuclease VIII; Reviewed; Region: PRK09709 877468008442 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 877468008443 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 877468008444 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 877468008445 dimer interface [polypeptide binding]; other site 877468008446 active site 877468008447 Int/Topo IB signature motif; other site 877468008448 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 877468008449 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 877468008450 hypothetical protein; Provisional; Region: PRK10301 877468008451 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 877468008452 Predicted amidohydrolase [General function prediction only]; Region: COG0388 877468008453 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 877468008454 exodeoxyribonuclease X; Provisional; Region: PRK07983 877468008455 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 877468008456 active site 877468008457 catalytic site [active] 877468008458 substrate binding site [chemical binding]; other site 877468008459 protease 2; Provisional; Region: PRK10115 877468008460 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 877468008461 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 877468008462 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 877468008463 putative metal binding site [ion binding]; other site 877468008464 hypothetical protein; Provisional; Region: PRK13680 877468008465 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 877468008466 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 877468008467 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 877468008468 ATP-grasp domain; Region: ATP-grasp; pfam02222 877468008469 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 877468008470 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 877468008471 active site 877468008472 intersubunit interface [polypeptide binding]; other site 877468008473 catalytic residue [active] 877468008474 phosphogluconate dehydratase; Validated; Region: PRK09054 877468008475 6-phosphogluconate dehydratase; Region: edd; TIGR01196 877468008476 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 877468008477 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 877468008478 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 877468008479 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 877468008480 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 877468008481 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 877468008482 putative active site [active] 877468008483 pyruvate kinase; Provisional; Region: PRK05826 877468008484 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 877468008485 domain interfaces; other site 877468008486 active site 877468008487 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 877468008488 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 877468008489 putative acyl-acceptor binding pocket; other site 877468008490 putative peptidase; Provisional; Region: PRK11649 877468008491 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 877468008492 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 877468008493 Peptidase family M23; Region: Peptidase_M23; pfam01551 877468008494 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 877468008495 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 877468008496 metal binding site [ion binding]; metal-binding site 877468008497 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 877468008498 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 877468008499 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 877468008500 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 877468008501 ABC-ATPase subunit interface; other site 877468008502 dimer interface [polypeptide binding]; other site 877468008503 putative PBP binding regions; other site 877468008504 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 877468008505 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 877468008506 Walker A motif; other site 877468008507 ATP binding site [chemical binding]; other site 877468008508 Walker B motif; other site 877468008509 arginine finger; other site 877468008510 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 877468008511 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 877468008512 RuvA N terminal domain; Region: RuvA_N; pfam01330 877468008513 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 877468008514 hypothetical protein; Provisional; Region: PRK11470 877468008515 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 877468008516 active site 877468008517 putative DNA-binding cleft [nucleotide binding]; other site 877468008518 dimer interface [polypeptide binding]; other site 877468008519 hypothetical protein; Validated; Region: PRK00110 877468008520 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 877468008521 nudix motif; other site 877468008522 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 877468008523 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 877468008524 dimer interface [polypeptide binding]; other site 877468008525 anticodon binding site; other site 877468008526 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 877468008527 homodimer interface [polypeptide binding]; other site 877468008528 motif 1; other site 877468008529 active site 877468008530 motif 2; other site 877468008531 GAD domain; Region: GAD; pfam02938 877468008532 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 877468008533 active site 877468008534 motif 3; other site 877468008535 Isochorismatase family; Region: Isochorismatase; pfam00857 877468008536 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 877468008537 catalytic triad [active] 877468008538 conserved cis-peptide bond; other site 877468008539 hypothetical protein; Provisional; Region: PRK10302 877468008540 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 877468008541 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 877468008542 S-adenosylmethionine binding site [chemical binding]; other site 877468008543 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 877468008544 S-adenosylmethionine binding site [chemical binding]; other site 877468008545 copper homeostasis protein CutC; Provisional; Region: PRK11572 877468008546 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 877468008547 putative metal binding site [ion binding]; other site 877468008548 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 877468008549 arginyl-tRNA synthetase; Region: argS; TIGR00456 877468008550 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 877468008551 active site 877468008552 HIGH motif; other site 877468008553 KMSK motif region; other site 877468008554 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 877468008555 tRNA binding surface [nucleotide binding]; other site 877468008556 anticodon binding site; other site 877468008557 penicillin-binding protein 2; Provisional; Region: PRK10795 877468008558 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 877468008559 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 877468008560 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 877468008561 Flagellar protein FlhE; Region: FlhE; pfam06366 877468008562 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 877468008563 FHIPEP family; Region: FHIPEP; pfam00771 877468008564 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 877468008565 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 877468008566 chemotaxis regulator CheZ; Provisional; Region: PRK11166 877468008567 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 877468008568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 877468008569 active site 877468008570 phosphorylation site [posttranslational modification] 877468008571 intermolecular recognition site; other site 877468008572 dimerization interface [polypeptide binding]; other site 877468008573 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 877468008574 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 877468008575 active site 877468008576 phosphorylation site [posttranslational modification] 877468008577 intermolecular recognition site; other site 877468008578 dimerization interface [polypeptide binding]; other site 877468008579 CheB methylesterase; Region: CheB_methylest; pfam01339 877468008580 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 877468008581 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 877468008582 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 877468008583 S-adenosylmethionine binding site [chemical binding]; other site 877468008584 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 877468008585 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 877468008586 dimer interface [polypeptide binding]; other site 877468008587 ligand binding site [chemical binding]; other site 877468008588 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 877468008589 dimerization interface [polypeptide binding]; other site 877468008590 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 877468008591 dimer interface [polypeptide binding]; other site 877468008592 putative CheW interface [polypeptide binding]; other site 877468008593 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 877468008594 putative CheA interaction surface; other site 877468008595 chemotaxis protein CheA; Provisional; Region: PRK10547 877468008596 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 877468008597 putative binding surface; other site 877468008598 active site 877468008599 CheY binding; Region: CheY-binding; pfam09078 877468008600 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 877468008601 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 877468008602 ATP binding site [chemical binding]; other site 877468008603 Mg2+ binding site [ion binding]; other site 877468008604 G-X-G motif; other site 877468008605 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 877468008606 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 877468008607 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 877468008608 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 877468008609 ligand binding site [chemical binding]; other site 877468008610 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 877468008611 flagellar motor protein MotA; Validated; Region: PRK09110 877468008612 transcriptional activator FlhC; Provisional; Region: PRK12722 877468008613 transcriptional activator FlhD; Provisional; Region: PRK02909 877468008614 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 877468008615 Ligand Binding Site [chemical binding]; other site 877468008616 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 877468008617 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 877468008618 active site 877468008619 homotetramer interface [polypeptide binding]; other site 877468008620 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 877468008621 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 877468008622 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 877468008623 DJ-1 family protein; Region: not_thiJ; TIGR01383 877468008624 conserved cys residue [active] 877468008625 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 877468008626 Ferritin-like domain; Region: Ferritin; pfam00210 877468008627 ferroxidase diiron center [ion binding]; other site 877468008628 hypothetical protein; Provisional; Region: PRK09273 877468008629 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 877468008630 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 877468008631 YecR-like lipoprotein; Region: YecR; pfam13992 877468008632 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 877468008633 Ferritin-like domain; Region: Ferritin; pfam00210 877468008634 ferroxidase diiron center [ion binding]; other site 877468008635 probable metal-binding protein; Region: matur_matur; TIGR03853 877468008636 tyrosine transporter TyrP; Provisional; Region: PRK15132 877468008637 aromatic amino acid transport protein; Region: araaP; TIGR00837 877468008638 hypothetical protein; Provisional; Region: PRK10396 877468008639 yecA family protein; Region: ygfB_yecA; TIGR02292 877468008640 SEC-C motif; Region: SEC-C; pfam02810 877468008641 glucose-6-phosphate 1-dehydrogenase; Region: PLN02640 877468008642 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 877468008643 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 877468008644 NlpC/P60 family; Region: NLPC_P60; cl17555 877468008645 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 877468008646 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 877468008647 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 877468008648 GIY-YIG motif/motif A; other site 877468008649 active site 877468008650 catalytic site [active] 877468008651 putative DNA binding site [nucleotide binding]; other site 877468008652 metal binding site [ion binding]; metal-binding site 877468008653 UvrB/uvrC motif; Region: UVR; pfam02151 877468008654 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 877468008655 Helix-hairpin-helix motif; Region: HHH; pfam00633 877468008656 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 877468008657 response regulator; Provisional; Region: PRK09483 877468008658 active site 877468008659 phosphorylation site [posttranslational modification] 877468008660 intermolecular recognition site; other site 877468008661 dimerization interface [polypeptide binding]; other site 877468008662 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 877468008663 DNA binding residues [nucleotide binding] 877468008664 dimerization interface [polypeptide binding]; other site 877468008665 hypothetical protein; Provisional; Region: PRK10613 877468008666 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 877468008667 Autoinducer binding domain; Region: Autoind_bind; pfam03472 877468008668 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 877468008669 DNA binding residues [nucleotide binding] 877468008670 dimerization interface [polypeptide binding]; other site 877468008671 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 877468008672 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 877468008673 Walker A/P-loop; other site 877468008674 ATP binding site [chemical binding]; other site 877468008675 Q-loop/lid; other site 877468008676 ABC transporter signature motif; other site 877468008677 Walker B; other site 877468008678 D-loop; other site 877468008679 H-loop/switch region; other site 877468008680 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 877468008681 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 877468008682 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468008683 dimer interface [polypeptide binding]; other site 877468008684 conserved gate region; other site 877468008685 putative PBP binding loops; other site 877468008686 ABC-ATPase subunit interface; other site 877468008687 D-cysteine desulfhydrase; Validated; Region: PRK03910 877468008688 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 877468008689 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468008690 catalytic residue [active] 877468008691 cystine transporter subunit; Provisional; Region: PRK11260 877468008692 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 877468008693 substrate binding pocket [chemical binding]; other site 877468008694 membrane-bound complex binding site; other site 877468008695 hinge residues; other site 877468008696 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 877468008697 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 877468008698 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 877468008699 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 877468008700 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 877468008701 DNA binding residues [nucleotide binding] 877468008702 flagellin; Validated; Region: PRK08026 877468008703 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 877468008704 Flagellin D3 domain; Region: Flagellin_D3; pfam08884 877468008705 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 877468008706 flagellar capping protein; Reviewed; Region: fliD; PRK08032 877468008707 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 877468008708 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 877468008709 flagellar protein FliS; Validated; Region: fliS; PRK05685 877468008710 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 877468008711 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 877468008712 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 877468008713 active site 877468008714 Na/Ca binding site [ion binding]; other site 877468008715 catalytic site [active] 877468008716 lipoprotein; Provisional; Region: PRK10397 877468008717 putative inner membrane protein; Provisional; Region: PRK11099 877468008718 Sulphur transport; Region: Sulf_transp; pfam04143 877468008719 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 877468008720 CPxP motif; other site 877468008721 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 877468008722 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 877468008723 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 877468008724 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 877468008725 flagellar motor switch protein FliG; Region: fliG; TIGR00207 877468008726 FliG C-terminal domain; Region: FliG_C; pfam01706 877468008727 flagellar assembly protein H; Validated; Region: fliH; PRK05687 877468008728 Flagellar assembly protein FliH; Region: FliH; pfam02108 877468008729 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 877468008730 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 877468008731 Walker A motif/ATP binding site; other site 877468008732 Walker B motif; other site 877468008733 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 877468008734 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 877468008735 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 877468008736 flagellar hook-length control protein; Provisional; Region: PRK10118 877468008737 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 877468008738 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 877468008739 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 877468008740 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 877468008741 flagellar motor switch protein; Validated; Region: fliN; PRK05698 877468008742 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 877468008743 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 877468008744 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 877468008745 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 877468008746 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 877468008747 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 877468008748 DNA binding residues [nucleotide binding] 877468008749 dimerization interface [polypeptide binding]; other site 877468008750 hypothetical protein; Provisional; Region: PRK10708 877468008751 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 877468008752 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 877468008753 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 877468008754 active site 877468008755 motif I; other site 877468008756 motif II; other site 877468008757 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 877468008758 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 877468008759 metal binding site [ion binding]; metal-binding site 877468008760 active site 877468008761 I-site; other site 877468008762 Uncharacterized small protein [Function unknown]; Region: COG5475 877468008763 hypothetical protein; Provisional; Region: PRK10062 877468008764 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 877468008765 EamA-like transporter family; Region: EamA; pfam00892 877468008766 EamA-like transporter family; Region: EamA; pfam00892 877468008767 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 877468008768 additional DNA contacts [nucleotide binding]; other site 877468008769 mismatch recognition site; other site 877468008770 active site 877468008771 zinc binding site [ion binding]; other site 877468008772 DNA intercalation site [nucleotide binding]; other site 877468008773 DNA cytosine methylase; Provisional; Region: PRK10458 877468008774 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 877468008775 cofactor binding site; other site 877468008776 DNA binding site [nucleotide binding] 877468008777 substrate interaction site [chemical binding]; other site 877468008778 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 877468008779 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 877468008780 Zn2+ binding site [ion binding]; other site 877468008781 Mg2+ binding site [ion binding]; other site 877468008782 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 877468008783 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 877468008784 trimer interface [polypeptide binding]; other site 877468008785 eyelet of channel; other site 877468008786 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 877468008787 DNA-binding site [nucleotide binding]; DNA binding site 877468008788 RNA-binding motif; other site 877468008789 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 877468008790 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 877468008791 active site 877468008792 DNA binding site [nucleotide binding] 877468008793 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 877468008794 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 877468008795 Catalytic site [active] 877468008796 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 877468008797 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 877468008798 putative protease; Region: PHA00666 877468008799 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 877468008800 Integrase; Region: Integrase_1; pfam12835 877468008801 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 877468008802 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 877468008803 Sel1 repeat; Region: Sel1; pfam08238 877468008804 Sel1-like repeats; Region: SEL1; smart00671 877468008805 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 877468008806 AMP nucleosidase; Provisional; Region: PRK08292 877468008807 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 877468008808 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 877468008809 MATE family multidrug exporter; Provisional; Region: PRK10189 877468008810 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 877468008811 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 877468008812 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 877468008813 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 877468008814 Sodium Bile acid symporter family; Region: SBF; cl17470 877468008815 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 877468008816 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 877468008817 P loop; other site 877468008818 Nucleotide binding site [chemical binding]; other site 877468008819 DTAP/Switch II; other site 877468008820 Switch I; other site 877468008821 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 877468008822 P loop; other site 877468008823 Nucleotide binding site [chemical binding]; other site 877468008824 DTAP/Switch II; other site 877468008825 Switch I; other site 877468008826 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 877468008827 Low molecular weight phosphatase family; Region: LMWPc; cd00115 877468008828 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 877468008829 active site 877468008830 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 877468008831 putative DNA binding site [nucleotide binding]; other site 877468008832 putative Zn2+ binding site [ion binding]; other site 877468008833 L,D-transpeptidase; Provisional; Region: PRK10190 877468008834 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 877468008835 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 877468008836 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 877468008837 putative dimer interface [polypeptide binding]; other site 877468008838 active site pocket [active] 877468008839 putative cataytic base [active] 877468008840 cobalamin synthase; Reviewed; Region: cobS; PRK00235 877468008841 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 877468008842 homotrimer interface [polypeptide binding]; other site 877468008843 Walker A motif; other site 877468008844 GTP binding site [chemical binding]; other site 877468008845 Walker B motif; other site 877468008846 cobyric acid synthase; Provisional; Region: PRK00784 877468008847 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 877468008848 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 877468008849 catalytic triad [active] 877468008850 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 877468008851 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 877468008852 Walker A/P-loop; other site 877468008853 ATP binding site [chemical binding]; other site 877468008854 Q-loop/lid; other site 877468008855 ABC transporter signature motif; other site 877468008856 Walker B; other site 877468008857 D-loop; other site 877468008858 H-loop/switch region; other site 877468008859 cobalt transport protein CbiQ; Provisional; Region: PRK15485 877468008860 cobalt transport protein CbiN; Provisional; Region: PRK02898 877468008861 cobalt transport protein CbiM; Validated; Region: PRK08319 877468008862 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 877468008863 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 877468008864 active site 877468008865 SAM binding site [chemical binding]; other site 877468008866 homodimer interface [polypeptide binding]; other site 877468008867 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 877468008868 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 877468008869 active site 877468008870 C-terminal domain interface [polypeptide binding]; other site 877468008871 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 877468008872 active site 877468008873 N-terminal domain interface [polypeptide binding]; other site 877468008874 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 877468008875 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 877468008876 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 877468008877 active site 877468008878 SAM binding site [chemical binding]; other site 877468008879 homodimer interface [polypeptide binding]; other site 877468008880 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 877468008881 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 877468008882 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 877468008883 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 877468008884 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 877468008885 active site 877468008886 SAM binding site [chemical binding]; other site 877468008887 homodimer interface [polypeptide binding]; other site 877468008888 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 877468008889 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 877468008890 S-adenosylmethionine binding site [chemical binding]; other site 877468008891 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 877468008892 putative homodimer interface [polypeptide binding]; other site 877468008893 active site 877468008894 SAM binding site [chemical binding]; other site 877468008895 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 877468008896 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 877468008897 Precorrin-8X methylmutase; Region: CbiC; pfam02570 877468008898 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 877468008899 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 877468008900 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 877468008901 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 877468008902 catalytic triad [active] 877468008903 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 877468008904 Sensory domain found in PocR; Region: PocR; pfam10114 877468008905 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 877468008906 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 877468008907 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 877468008908 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 877468008909 amphipathic channel; other site 877468008910 Asn-Pro-Ala signature motifs; other site 877468008911 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 877468008912 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 877468008913 Hexamer interface [polypeptide binding]; other site 877468008914 Putative hexagonal pore residue; other site 877468008915 propanediol utilization protein PduB; Provisional; Region: PRK15415 877468008916 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 877468008917 putative hexamer interface [polypeptide binding]; other site 877468008918 putative hexagonal pore; other site 877468008919 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 877468008920 putative hexamer interface [polypeptide binding]; other site 877468008921 putative hexagonal pore; other site 877468008922 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 877468008923 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 877468008924 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 877468008925 alpha-beta subunit interface [polypeptide binding]; other site 877468008926 alpha-gamma subunit interface [polypeptide binding]; other site 877468008927 active site 877468008928 substrate and K+ binding site; other site 877468008929 K+ binding site [ion binding]; other site 877468008930 cobalamin binding site [chemical binding]; other site 877468008931 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 877468008932 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 877468008933 Cell division protein FtsA; Region: FtsA; cl17206 877468008934 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 877468008935 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 877468008936 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 877468008937 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 877468008938 Hexamer interface [polypeptide binding]; other site 877468008939 Putative hexagonal pore residue; other site 877468008940 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 877468008941 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 877468008942 putative hexamer interface [polypeptide binding]; other site 877468008943 putative hexagonal pore; other site 877468008944 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 877468008945 Propanediol utilisation protein PduL; Region: PduL; pfam06130 877468008946 Propanediol utilisation protein PduL; Region: PduL; pfam06130 877468008947 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 877468008948 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 877468008949 Hexamer/Pentamer interface [polypeptide binding]; other site 877468008950 central pore; other site 877468008951 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 877468008952 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 877468008953 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 877468008954 putative catalytic cysteine [active] 877468008955 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 877468008956 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 877468008957 putative active site [active] 877468008958 metal binding site [ion binding]; metal-binding site 877468008959 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 877468008960 SLBB domain; Region: SLBB; pfam10531 877468008961 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 877468008962 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 877468008963 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 877468008964 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 877468008965 putative hexamer interface [polypeptide binding]; other site 877468008966 putative hexagonal pore; other site 877468008967 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 877468008968 putative hexamer interface [polypeptide binding]; other site 877468008969 putative hexagonal pore; other site 877468008970 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 877468008971 putative hexamer interface [polypeptide binding]; other site 877468008972 putative hexagonal pore; other site 877468008973 Ethanolamine utilisation - propanediol utilisation; Region: PduV-EutP; pfam10662 877468008974 G3 box; other site 877468008975 Switch II region; other site 877468008976 GTP/Mg2+ binding site [chemical binding]; other site 877468008977 G4 box; other site 877468008978 G5 box; other site 877468008979 propionate kinase; Reviewed; Region: PRK12397 877468008980 propionate/acetate kinase; Provisional; Region: PRK12379 877468008981 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 877468008982 hypothetical protein; Provisional; Region: PRK05423 877468008983 Predicted membrane protein [Function unknown]; Region: COG1289 877468008984 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 877468008985 DNA gyrase inhibitor; Provisional; Region: PRK10016 877468008986 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 877468008987 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 877468008988 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 877468008989 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 877468008990 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 877468008991 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 877468008992 4Fe-4S binding domain; Region: Fer4; cl02805 877468008993 thiosulfate reductase PhsA; Provisional; Region: PRK15488 877468008994 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 877468008995 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 877468008996 putative [Fe4-S4] binding site [ion binding]; other site 877468008997 putative molybdopterin cofactor binding site [chemical binding]; other site 877468008998 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 877468008999 putative molybdopterin cofactor binding site; other site 877468009000 E3 ubiquitin-protein ligase SopA; Provisional; Region: PRK15377 877468009001 SopA-like central domain; Region: SopA; pfam13981 877468009002 SopA-like catalytic domain; Region: SopA_C; pfam13979 877468009003 exonuclease I; Provisional; Region: sbcB; PRK11779 877468009004 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 877468009005 active site 877468009006 catalytic site [active] 877468009007 substrate binding site [chemical binding]; other site 877468009008 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 877468009009 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 877468009010 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468009011 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 877468009012 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 877468009013 dimerization interface [polypeptide binding]; other site 877468009014 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 877468009015 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 877468009016 putative NAD(P) binding site [chemical binding]; other site 877468009017 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 877468009018 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 877468009019 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 877468009020 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 877468009021 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 877468009022 NAD binding site [chemical binding]; other site 877468009023 dimerization interface [polypeptide binding]; other site 877468009024 product binding site; other site 877468009025 substrate binding site [chemical binding]; other site 877468009026 zinc binding site [ion binding]; other site 877468009027 catalytic residues [active] 877468009028 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 877468009029 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 877468009030 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468009031 homodimer interface [polypeptide binding]; other site 877468009032 catalytic residue [active] 877468009033 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 877468009034 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 877468009035 active site 877468009036 motif I; other site 877468009037 motif II; other site 877468009038 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 877468009039 putative active site pocket [active] 877468009040 4-fold oligomerization interface [polypeptide binding]; other site 877468009041 metal binding residues [ion binding]; metal-binding site 877468009042 3-fold/trimer interface [polypeptide binding]; other site 877468009043 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 877468009044 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 877468009045 putative active site [active] 877468009046 oxyanion strand; other site 877468009047 catalytic triad [active] 877468009048 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 877468009049 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 877468009050 catalytic residues [active] 877468009051 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 877468009052 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 877468009053 substrate binding site [chemical binding]; other site 877468009054 glutamase interaction surface [polypeptide binding]; other site 877468009055 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 877468009056 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 877468009057 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 877468009058 metal binding site [ion binding]; metal-binding site 877468009059 chain length determinant protein WzzB; Provisional; Region: PRK15471 877468009060 Chain length determinant protein; Region: Wzz; cl15801 877468009061 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 877468009062 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 877468009063 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 877468009064 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 877468009065 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 877468009066 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 877468009067 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 877468009068 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 877468009069 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 877468009070 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 877468009071 Bacterial sugar transferase; Region: Bac_transf; pfam02397 877468009072 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 877468009073 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 877468009074 active site 877468009075 substrate binding site [chemical binding]; other site 877468009076 metal binding site [ion binding]; metal-binding site 877468009077 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 877468009078 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 877468009079 Substrate binding site; other site 877468009080 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 877468009081 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 877468009082 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 877468009083 putative ADP-binding pocket [chemical binding]; other site 877468009084 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 877468009085 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 877468009086 O-Antigen ligase; Region: Wzy_C; cl04850 877468009087 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 877468009088 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 877468009089 active site 877468009090 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 877468009091 trimer interface [polypeptide binding]; other site 877468009092 active site 877468009093 substrate binding site [chemical binding]; other site 877468009094 CoA binding site [chemical binding]; other site 877468009095 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 877468009096 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 877468009097 active site 877468009098 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 877468009099 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 877468009100 NAD(P) binding site [chemical binding]; other site 877468009101 active site 877468009102 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 877468009103 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 877468009104 inhibitor-cofactor binding pocket; inhibition site 877468009105 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468009106 catalytic residue [active] 877468009107 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 877468009108 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 877468009109 NAD binding site [chemical binding]; other site 877468009110 homotetramer interface [polypeptide binding]; other site 877468009111 homodimer interface [polypeptide binding]; other site 877468009112 substrate binding site [chemical binding]; other site 877468009113 active site 877468009114 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 877468009115 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 877468009116 substrate binding site; other site 877468009117 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 877468009118 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 877468009119 catalytic loop [active] 877468009120 iron binding site [ion binding]; other site 877468009121 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 877468009122 FAD binding pocket [chemical binding]; other site 877468009123 FAD binding motif [chemical binding]; other site 877468009124 phosphate binding motif [ion binding]; other site 877468009125 beta-alpha-beta structure motif; other site 877468009126 NAD binding pocket [chemical binding]; other site 877468009127 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 877468009128 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 877468009129 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 877468009130 substrate binding site; other site 877468009131 tetramer interface; other site 877468009132 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 877468009133 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 877468009134 NADP binding site [chemical binding]; other site 877468009135 active site 877468009136 putative substrate binding site [chemical binding]; other site 877468009137 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 877468009138 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 877468009139 NAD binding site [chemical binding]; other site 877468009140 substrate binding site [chemical binding]; other site 877468009141 homodimer interface [polypeptide binding]; other site 877468009142 active site 877468009143 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 877468009144 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 877468009145 active site 877468009146 tetramer interface; other site 877468009147 colanic acid biosynthesis protein WcaM; Region: WcaM; TIGR04004 877468009148 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 877468009149 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 877468009150 putative ADP-binding pocket [chemical binding]; other site 877468009151 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 877468009152 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 877468009153 colanic acid exporter; Provisional; Region: PRK10459 877468009154 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 877468009155 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 877468009156 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 877468009157 phosphomannomutase CpsG; Provisional; Region: PRK15414 877468009158 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 877468009159 active site 877468009160 substrate binding site [chemical binding]; other site 877468009161 metal binding site [ion binding]; metal-binding site 877468009162 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 877468009163 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 877468009164 Substrate binding site; other site 877468009165 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 877468009166 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 877468009167 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 877468009168 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 877468009169 active site 877468009170 GDP-Mannose binding site [chemical binding]; other site 877468009171 dimer interface [polypeptide binding]; other site 877468009172 modified nudix motif 877468009173 metal binding site [ion binding]; metal-binding site 877468009174 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 877468009175 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 877468009176 NADP binding site [chemical binding]; other site 877468009177 active site 877468009178 putative substrate binding site [chemical binding]; other site 877468009179 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 877468009180 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 877468009181 NADP-binding site; other site 877468009182 homotetramer interface [polypeptide binding]; other site 877468009183 substrate binding site [chemical binding]; other site 877468009184 homodimer interface [polypeptide binding]; other site 877468009185 active site 877468009186 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 877468009187 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 877468009188 putative trimer interface [polypeptide binding]; other site 877468009189 putative active site [active] 877468009190 putative substrate binding site [chemical binding]; other site 877468009191 putative CoA binding site [chemical binding]; other site 877468009192 putative glycosyl transferase; Provisional; Region: PRK10063 877468009193 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 877468009194 metal-binding site 877468009195 putative colanic acid biosynthesis protein; Provisional; Region: wcaD; cl08075 877468009196 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 877468009197 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 877468009198 putative acyl transferase; Provisional; Region: PRK10191 877468009199 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 877468009200 trimer interface [polypeptide binding]; other site 877468009201 active site 877468009202 substrate binding site [chemical binding]; other site 877468009203 CoA binding site [chemical binding]; other site 877468009204 putative glycosyl transferase; Provisional; Region: PRK10018 877468009205 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 877468009206 active site 877468009207 tyrosine kinase; Provisional; Region: PRK11519 877468009208 Chain length determinant protein; Region: Wzz; pfam02706 877468009209 Chain length determinant protein; Region: Wzz; cl15801 877468009210 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 877468009211 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 877468009212 Low molecular weight phosphatase family; Region: LMWPc; cd00115 877468009213 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 877468009214 active site 877468009215 polysaccharide export protein Wza; Provisional; Region: PRK15078 877468009216 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 877468009217 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 877468009218 FOG: CBS domain [General function prediction only]; Region: COG0517 877468009219 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 877468009220 Transporter associated domain; Region: CorC_HlyC; smart01091 877468009221 putative assembly protein; Provisional; Region: PRK10833 877468009222 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 877468009223 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 877468009224 trimer interface [polypeptide binding]; other site 877468009225 active site 877468009226 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 877468009227 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 877468009228 ATP-binding site [chemical binding]; other site 877468009229 Sugar specificity; other site 877468009230 Pyrimidine base specificity; other site 877468009231 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 877468009232 PAS domain S-box; Region: sensory_box; TIGR00229 877468009233 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 877468009234 putative active site [active] 877468009235 heme pocket [chemical binding]; other site 877468009236 PAS domain S-box; Region: sensory_box; TIGR00229 877468009237 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 877468009238 putative active site [active] 877468009239 heme pocket [chemical binding]; other site 877468009240 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 877468009241 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 877468009242 metal binding site [ion binding]; metal-binding site 877468009243 active site 877468009244 I-site; other site 877468009245 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 877468009246 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 877468009247 AlkA N-terminal domain; Region: AlkA_N; pfam06029 877468009248 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 877468009249 minor groove reading motif; other site 877468009250 helix-hairpin-helix signature motif; other site 877468009251 substrate binding pocket [chemical binding]; other site 877468009252 active site 877468009253 putative chaperone; Provisional; Region: PRK11678 877468009254 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 877468009255 nucleotide binding site [chemical binding]; other site 877468009256 putative NEF/HSP70 interaction site [polypeptide binding]; other site 877468009257 SBD interface [polypeptide binding]; other site 877468009258 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 877468009259 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 877468009260 HlyD family secretion protein; Region: HlyD_3; pfam13437 877468009261 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 877468009262 Protein export membrane protein; Region: SecD_SecF; cl14618 877468009263 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 877468009264 putative transporter; Provisional; Region: PRK10504 877468009265 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468009266 putative substrate translocation pore; other site 877468009267 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 877468009268 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 877468009269 dimerization interface [polypeptide binding]; other site 877468009270 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 877468009271 dimer interface [polypeptide binding]; other site 877468009272 phosphorylation site [posttranslational modification] 877468009273 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 877468009274 ATP binding site [chemical binding]; other site 877468009275 Mg2+ binding site [ion binding]; other site 877468009276 G-X-G motif; other site 877468009277 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 877468009278 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 877468009279 active site 877468009280 phosphorylation site [posttranslational modification] 877468009281 intermolecular recognition site; other site 877468009282 dimerization interface [polypeptide binding]; other site 877468009283 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 877468009284 DNA binding site [nucleotide binding] 877468009285 PcfJ-like protein; Region: PcfJ; pfam14284 877468009286 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 877468009287 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 877468009288 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 877468009289 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 877468009290 putative protease; Provisional; Region: PRK15452 877468009291 Peptidase family U32; Region: Peptidase_U32; pfam01136 877468009292 type III secretion system protein; Provisional; Region: PRK15384; cl14665 877468009293 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 877468009294 lipid kinase; Reviewed; Region: PRK13054 877468009295 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 877468009296 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 877468009297 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 877468009298 putative active site; other site 877468009299 catalytic residue [active] 877468009300 nucleoside transporter; Region: 2A0110; TIGR00889 877468009301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468009302 putative substrate translocation pore; other site 877468009303 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 877468009304 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 877468009305 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 877468009306 substrate binding site [chemical binding]; other site 877468009307 ATP binding site [chemical binding]; other site 877468009308 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 877468009309 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 877468009310 DNA-binding site [nucleotide binding]; DNA binding site 877468009311 UTRA domain; Region: UTRA; pfam07702 877468009312 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 877468009313 dimer interface [polypeptide binding]; other site 877468009314 substrate binding site [chemical binding]; other site 877468009315 ATP binding site [chemical binding]; other site 877468009316 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 877468009317 substrate binding site [chemical binding]; other site 877468009318 multimerization interface [polypeptide binding]; other site 877468009319 ATP binding site [chemical binding]; other site 877468009320 Predicted integral membrane protein [Function unknown]; Region: COG5455 877468009321 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 877468009322 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 877468009323 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 877468009324 PapC N-terminal domain; Region: PapC_N; pfam13954 877468009325 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 877468009326 PapC C-terminal domain; Region: PapC_C; pfam13953 877468009327 fimbrial chaperone protein PegB; Provisional; Region: PRK15218 877468009328 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 877468009329 fimbrial chaperone protein; Provisional; Region: PRK15220 877468009330 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 877468009331 antiporter inner membrane protein; Provisional; Region: PRK11670 877468009332 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 877468009333 Walker A motif; other site 877468009334 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 877468009335 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 877468009336 active site 877468009337 HIGH motif; other site 877468009338 KMSKS motif; other site 877468009339 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 877468009340 tRNA binding surface [nucleotide binding]; other site 877468009341 anticodon binding site; other site 877468009342 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 877468009343 dimer interface [polypeptide binding]; other site 877468009344 putative tRNA-binding site [nucleotide binding]; other site 877468009345 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 877468009346 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 877468009347 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 877468009348 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 877468009349 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 877468009350 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 877468009351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 877468009352 active site 877468009353 phosphorylation site [posttranslational modification] 877468009354 intermolecular recognition site; other site 877468009355 dimerization interface [polypeptide binding]; other site 877468009356 LytTr DNA-binding domain; Region: LytTR; pfam04397 877468009357 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 877468009358 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 877468009359 GAF domain; Region: GAF; pfam01590 877468009360 Histidine kinase; Region: His_kinase; pfam06580 877468009361 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 877468009362 ATP binding site [chemical binding]; other site 877468009363 Mg2+ binding site [ion binding]; other site 877468009364 G-X-G motif; other site 877468009365 transcriptional regulator MirA; Provisional; Region: PRK15043 877468009366 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 877468009367 DNA binding residues [nucleotide binding] 877468009368 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 877468009369 putative PBP binding loops; other site 877468009370 ABC-ATPase subunit interface; other site 877468009371 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 877468009372 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 877468009373 Walker A/P-loop; other site 877468009374 ATP binding site [chemical binding]; other site 877468009375 Q-loop/lid; other site 877468009376 ABC transporter signature motif; other site 877468009377 Walker B; other site 877468009378 D-loop; other site 877468009379 H-loop/switch region; other site 877468009380 CBS domain; Region: CBS; pfam00571 877468009381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468009382 dimer interface [polypeptide binding]; other site 877468009383 conserved gate region; other site 877468009384 ABC-ATPase subunit interface; other site 877468009385 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 877468009386 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 877468009387 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 877468009388 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 877468009389 D-lactate dehydrogenase; Provisional; Region: PRK11183 877468009390 FAD binding domain; Region: FAD_binding_4; pfam01565 877468009391 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 877468009392 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 877468009393 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 877468009394 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 877468009395 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 877468009396 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 877468009397 oxidoreductase; Provisional; Region: PRK12743 877468009398 classical (c) SDRs; Region: SDR_c; cd05233 877468009399 NAD(P) binding site [chemical binding]; other site 877468009400 active site 877468009401 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 877468009402 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 877468009403 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 877468009404 FMN binding site [chemical binding]; other site 877468009405 active site 877468009406 catalytic residues [active] 877468009407 substrate binding site [chemical binding]; other site 877468009408 salicylate hydroxylase; Provisional; Region: PRK08163 877468009409 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 877468009410 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 877468009411 maleylacetoacetate isomerase; Region: maiA; TIGR01262 877468009412 C-terminal domain interface [polypeptide binding]; other site 877468009413 GSH binding site (G-site) [chemical binding]; other site 877468009414 putative dimer interface [polypeptide binding]; other site 877468009415 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 877468009416 dimer interface [polypeptide binding]; other site 877468009417 N-terminal domain interface [polypeptide binding]; other site 877468009418 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 877468009419 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 877468009420 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 877468009421 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 877468009422 Cupin domain; Region: Cupin_2; pfam07883 877468009423 Cupin domain; Region: Cupin_2; pfam07883 877468009424 benzoate transport; Region: 2A0115; TIGR00895 877468009425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468009426 putative substrate translocation pore; other site 877468009427 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 877468009428 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468009429 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 877468009430 dimerization interface [polypeptide binding]; other site 877468009431 hypothetical protein; Provisional; Region: PRK01821 877468009432 hypothetical protein; Provisional; Region: PRK10711 877468009433 cytidine deaminase; Provisional; Region: PRK09027 877468009434 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 877468009435 active site 877468009436 catalytic motif [active] 877468009437 Zn binding site [ion binding]; other site 877468009438 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 877468009439 active site 877468009440 catalytic motif [active] 877468009441 Zn binding site [ion binding]; other site 877468009442 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 877468009443 putative active site [active] 877468009444 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 877468009445 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 877468009446 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 877468009447 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 877468009448 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 877468009449 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 877468009450 homodimer interface [polypeptide binding]; other site 877468009451 active site 877468009452 FMN binding site [chemical binding]; other site 877468009453 substrate binding site [chemical binding]; other site 877468009454 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 877468009455 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 877468009456 TM-ABC transporter signature motif; other site 877468009457 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 877468009458 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 877468009459 Walker A/P-loop; other site 877468009460 ATP binding site [chemical binding]; other site 877468009461 Q-loop/lid; other site 877468009462 ABC transporter signature motif; other site 877468009463 Walker B; other site 877468009464 D-loop; other site 877468009465 H-loop/switch region; other site 877468009466 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 877468009467 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 877468009468 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 877468009469 ligand binding site [chemical binding]; other site 877468009470 calcium binding site [ion binding]; other site 877468009471 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 877468009472 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 877468009473 DNA binding site [nucleotide binding] 877468009474 domain linker motif; other site 877468009475 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 877468009476 dimerization interface (closed form) [polypeptide binding]; other site 877468009477 ligand binding site [chemical binding]; other site 877468009478 Predicted membrane protein [Function unknown]; Region: COG2311 877468009479 hypothetical protein; Provisional; Region: PRK10835 877468009480 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 877468009481 GTP cyclohydrolase I; Provisional; Region: PLN03044 877468009482 active site 877468009483 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 877468009484 S-formylglutathione hydrolase; Region: PLN02442 877468009485 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 877468009486 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 877468009487 non-specific DNA binding site [nucleotide binding]; other site 877468009488 salt bridge; other site 877468009489 sequence-specific DNA binding site [nucleotide binding]; other site 877468009490 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 877468009491 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 877468009492 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 877468009493 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 877468009494 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 877468009495 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 877468009496 motif II; other site 877468009497 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 877468009498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468009499 putative substrate translocation pore; other site 877468009500 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 877468009501 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 877468009502 N-terminal plug; other site 877468009503 ligand-binding site [chemical binding]; other site 877468009504 lysine transporter; Provisional; Region: PRK10836 877468009505 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 877468009506 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468009507 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 877468009508 putative dimerization interface [polypeptide binding]; other site 877468009509 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 877468009510 endonuclease IV; Provisional; Region: PRK01060 877468009511 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 877468009512 AP (apurinic/apyrimidinic) site pocket; other site 877468009513 DNA interaction; other site 877468009514 Metal-binding active site; metal-binding site 877468009515 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 877468009516 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 877468009517 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 877468009518 active site 877468009519 P-loop; other site 877468009520 phosphorylation site [posttranslational modification] 877468009521 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 877468009522 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 877468009523 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 877468009524 putative substrate binding site [chemical binding]; other site 877468009525 putative ATP binding site [chemical binding]; other site 877468009526 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 877468009527 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 877468009528 active site 877468009529 phosphorylation site [posttranslational modification] 877468009530 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 877468009531 dimerization domain swap beta strand [polypeptide binding]; other site 877468009532 regulatory protein interface [polypeptide binding]; other site 877468009533 active site 877468009534 regulatory phosphorylation site [posttranslational modification]; other site 877468009535 sugar efflux transporter B; Provisional; Region: PRK15011 877468009536 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468009537 putative substrate translocation pore; other site 877468009538 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 877468009539 elongation factor P; Provisional; Region: PRK04542 877468009540 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 877468009541 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 877468009542 RNA binding site [nucleotide binding]; other site 877468009543 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 877468009544 RNA binding site [nucleotide binding]; other site 877468009545 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 877468009546 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 877468009547 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 877468009548 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 877468009549 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 877468009550 active site 877468009551 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 877468009552 NlpC/P60 family; Region: NLPC_P60; pfam00877 877468009553 phage resistance protein; Provisional; Region: PRK10551 877468009554 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 877468009555 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 877468009556 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 877468009557 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 877468009558 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 877468009559 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468009560 dimer interface [polypeptide binding]; other site 877468009561 conserved gate region; other site 877468009562 putative PBP binding loops; other site 877468009563 ABC-ATPase subunit interface; other site 877468009564 microcin C ABC transporter permease; Provisional; Region: PRK15021 877468009565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468009566 dimer interface [polypeptide binding]; other site 877468009567 conserved gate region; other site 877468009568 ABC-ATPase subunit interface; other site 877468009569 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 877468009570 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 877468009571 Walker A/P-loop; other site 877468009572 ATP binding site [chemical binding]; other site 877468009573 Q-loop/lid; other site 877468009574 ABC transporter signature motif; other site 877468009575 Walker B; other site 877468009576 D-loop; other site 877468009577 H-loop/switch region; other site 877468009578 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 877468009579 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 877468009580 Walker A/P-loop; other site 877468009581 ATP binding site [chemical binding]; other site 877468009582 Q-loop/lid; other site 877468009583 ABC transporter signature motif; other site 877468009584 Walker B; other site 877468009585 D-loop; other site 877468009586 H-loop/switch region; other site 877468009587 hypothetical protein; Provisional; Region: PRK11835 877468009588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468009589 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 877468009590 putative substrate translocation pore; other site 877468009591 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 877468009592 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 877468009593 RNA binding surface [nucleotide binding]; other site 877468009594 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 877468009595 active site 877468009596 uracil binding [chemical binding]; other site 877468009597 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 877468009598 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 877468009599 ATP binding site [chemical binding]; other site 877468009600 putative Mg++ binding site [ion binding]; other site 877468009601 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 877468009602 nucleotide binding region [chemical binding]; other site 877468009603 ATP-binding site [chemical binding]; other site 877468009604 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 877468009605 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 877468009606 5S rRNA interface [nucleotide binding]; other site 877468009607 CTC domain interface [polypeptide binding]; other site 877468009608 L16 interface [polypeptide binding]; other site 877468009609 Nucleoid-associated protein [General function prediction only]; Region: COG3081 877468009610 nucleoid-associated protein NdpA; Validated; Region: PRK00378 877468009611 hypothetical protein; Provisional; Region: PRK13689 877468009612 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 877468009613 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 877468009614 Sulfatase; Region: Sulfatase; cl17466 877468009615 E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387 877468009616 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 877468009617 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 877468009618 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 877468009619 Leucine-rich repeats; other site 877468009620 Substrate binding site [chemical binding]; other site 877468009621 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 877468009622 DinI-like family; Region: DinI; cl11630 877468009623 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 877468009624 transcriptional regulator NarP; Provisional; Region: PRK10403 877468009625 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 877468009626 active site 877468009627 phosphorylation site [posttranslational modification] 877468009628 intermolecular recognition site; other site 877468009629 dimerization interface [polypeptide binding]; other site 877468009630 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 877468009631 DNA binding residues [nucleotide binding] 877468009632 dimerization interface [polypeptide binding]; other site 877468009633 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 877468009634 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 877468009635 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 877468009636 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 877468009637 catalytic residues [active] 877468009638 central insert; other site 877468009639 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 877468009640 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150 877468009641 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 877468009642 heme exporter protein CcmC; Region: ccmC; TIGR01191 877468009643 heme exporter protein CcmB; Region: ccmB; TIGR01190 877468009644 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 877468009645 Walker A/P-loop; other site 877468009646 ATP binding site [chemical binding]; other site 877468009647 Q-loop/lid; other site 877468009648 ABC transporter signature motif; other site 877468009649 Walker B; other site 877468009650 D-loop; other site 877468009651 H-loop/switch region; other site 877468009652 cytochrome c-type protein NapC; Provisional; Region: PRK10617 877468009653 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 877468009654 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 877468009655 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 877468009656 4Fe-4S binding domain; Region: Fer4_5; pfam12801 877468009657 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 877468009658 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 877468009659 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 877468009660 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 877468009661 [4Fe-4S] binding site [ion binding]; other site 877468009662 molybdopterin cofactor binding site; other site 877468009663 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 877468009664 molybdopterin cofactor binding site; other site 877468009665 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 877468009666 4Fe-4S binding domain; Region: Fer4; cl02805 877468009667 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 877468009668 secondary substrate binding site; other site 877468009669 primary substrate binding site; other site 877468009670 inhibition loop; other site 877468009671 dimerization interface [polypeptide binding]; other site 877468009672 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 877468009673 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 877468009674 Walker A/P-loop; other site 877468009675 ATP binding site [chemical binding]; other site 877468009676 Q-loop/lid; other site 877468009677 ABC transporter signature motif; other site 877468009678 Walker B; other site 877468009679 D-loop; other site 877468009680 H-loop/switch region; other site 877468009681 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 877468009682 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 877468009683 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 877468009684 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 877468009685 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 877468009686 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 877468009687 DNA binding site [nucleotide binding] 877468009688 active site 877468009689 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 877468009690 ApbE family; Region: ApbE; pfam02424 877468009691 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 877468009692 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 877468009693 trimer interface [polypeptide binding]; other site 877468009694 eyelet of channel; other site 877468009695 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 877468009696 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 877468009697 ATP binding site [chemical binding]; other site 877468009698 G-X-G motif; other site 877468009699 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 877468009700 putative binding surface; other site 877468009701 active site 877468009702 transcriptional regulator RcsB; Provisional; Region: PRK10840 877468009703 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 877468009704 active site 877468009705 phosphorylation site [posttranslational modification] 877468009706 intermolecular recognition site; other site 877468009707 dimerization interface [polypeptide binding]; other site 877468009708 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 877468009709 DNA binding residues [nucleotide binding] 877468009710 dimerization interface [polypeptide binding]; other site 877468009711 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 877468009712 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 877468009713 dimer interface [polypeptide binding]; other site 877468009714 phosphorylation site [posttranslational modification] 877468009715 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 877468009716 ATP binding site [chemical binding]; other site 877468009717 Mg2+ binding site [ion binding]; other site 877468009718 G-X-G motif; other site 877468009719 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 877468009720 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 877468009721 active site 877468009722 phosphorylation site [posttranslational modification] 877468009723 intermolecular recognition site; other site 877468009724 dimerization interface [polypeptide binding]; other site 877468009725 DNA gyrase subunit A; Validated; Region: PRK05560 877468009726 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 877468009727 CAP-like domain; other site 877468009728 active site 877468009729 primary dimer interface [polypeptide binding]; other site 877468009730 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 877468009731 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 877468009732 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 877468009733 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 877468009734 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 877468009735 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 877468009736 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 877468009737 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 877468009738 active site pocket [active] 877468009739 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 877468009740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468009741 putative substrate translocation pore; other site 877468009742 Transcriptional regulators [Transcription]; Region: GntR; COG1802 877468009743 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 877468009744 DNA-binding site [nucleotide binding]; DNA binding site 877468009745 FCD domain; Region: FCD; pfam07729 877468009746 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 877468009747 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 877468009748 S-adenosylmethionine binding site [chemical binding]; other site 877468009749 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 877468009750 ATP cone domain; Region: ATP-cone; pfam03477 877468009751 Class I ribonucleotide reductase; Region: RNR_I; cd01679 877468009752 active site 877468009753 dimer interface [polypeptide binding]; other site 877468009754 catalytic residues [active] 877468009755 effector binding site; other site 877468009756 R2 peptide binding site; other site 877468009757 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 877468009758 dimer interface [polypeptide binding]; other site 877468009759 putative radical transfer pathway; other site 877468009760 diiron center [ion binding]; other site 877468009761 tyrosyl radical; other site 877468009762 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 877468009763 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 877468009764 catalytic loop [active] 877468009765 iron binding site [ion binding]; other site 877468009766 Major Facilitator Superfamily; Region: MFS_1; pfam07690 877468009767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468009768 putative substrate translocation pore; other site 877468009769 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 877468009770 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468009771 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 877468009772 dimerization interface [polypeptide binding]; other site 877468009773 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 877468009774 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 877468009775 active site 877468009776 catalytic site [active] 877468009777 metal binding site [ion binding]; metal-binding site 877468009778 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 877468009779 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468009780 putative substrate translocation pore; other site 877468009781 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 877468009782 hydroxyglutarate oxidase; Provisional; Region: PRK11728 877468009783 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 877468009784 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 877468009785 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 877468009786 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 877468009787 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 877468009788 Cysteine-rich domain; Region: CCG; pfam02754 877468009789 Cysteine-rich domain; Region: CCG; pfam02754 877468009790 deubiquitinase SseL; Provisional; Region: PRK14848 877468009791 hypothetical protein; Provisional; Region: PRK03673 877468009792 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 877468009793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468009794 D-galactonate transporter; Region: 2A0114; TIGR00893 877468009795 putative substrate translocation pore; other site 877468009796 L-rhamnonate dehydratase; Provisional; Region: PRK15440 877468009797 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 877468009798 putative active site pocket [active] 877468009799 putative metal binding site [ion binding]; other site 877468009800 Transcriptional regulator [Transcription]; Region: IclR; COG1414 877468009801 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 877468009802 Bacterial transcriptional regulator; Region: IclR; pfam01614 877468009803 hypothetical protein; Provisional; Region: PRK03673 877468009804 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 877468009805 putative MPT binding site; other site 877468009806 Competence-damaged protein; Region: CinA; cl00666 877468009807 YfaZ precursor; Region: YfaZ; pfam07437 877468009808 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 877468009809 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 877468009810 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 877468009811 catalytic core [active] 877468009812 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 877468009813 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 877468009814 inhibitor-cofactor binding pocket; inhibition site 877468009815 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468009816 catalytic residue [active] 877468009817 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 877468009818 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 877468009819 Ligand binding site; other site 877468009820 Putative Catalytic site; other site 877468009821 DXD motif; other site 877468009822 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 877468009823 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 877468009824 active site 877468009825 substrate binding site [chemical binding]; other site 877468009826 cosubstrate binding site; other site 877468009827 catalytic site [active] 877468009828 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 877468009829 active site 877468009830 hexamer interface [polypeptide binding]; other site 877468009831 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 877468009832 NAD binding site [chemical binding]; other site 877468009833 substrate binding site [chemical binding]; other site 877468009834 active site 877468009835 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 877468009836 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 877468009837 putative active site [active] 877468009838 putative catalytic site [active] 877468009839 putative Zn binding site [ion binding]; other site 877468009840 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 877468009841 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 877468009842 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 877468009843 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 877468009844 signal transduction protein PmrD; Provisional; Region: PRK15450 877468009845 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 877468009846 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 877468009847 acyl-activating enzyme (AAE) consensus motif; other site 877468009848 putative AMP binding site [chemical binding]; other site 877468009849 putative active site [active] 877468009850 putative CoA binding site [chemical binding]; other site 877468009851 O-succinylbenzoate synthase [Coenzyme metabolism]; Region: MenC; COG1441 877468009852 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 877468009853 active site 877468009854 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 877468009855 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 877468009856 substrate binding site [chemical binding]; other site 877468009857 oxyanion hole (OAH) forming residues; other site 877468009858 trimer interface [polypeptide binding]; other site 877468009859 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 877468009860 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 877468009861 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 877468009862 dimer interface [polypeptide binding]; other site 877468009863 tetramer interface [polypeptide binding]; other site 877468009864 PYR/PP interface [polypeptide binding]; other site 877468009865 TPP binding site [chemical binding]; other site 877468009866 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 877468009867 TPP-binding site; other site 877468009868 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 877468009869 isochorismate synthases; Region: isochor_syn; TIGR00543 877468009870 hypothetical protein; Provisional; Region: PRK10404 877468009871 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 877468009872 Coenzyme A binding pocket [chemical binding]; other site 877468009873 ribonuclease BN; Region: true_RNase_BN; TIGR02649 877468009874 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 877468009875 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 877468009876 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 877468009877 active site 877468009878 phosphorylation site [posttranslational modification] 877468009879 intermolecular recognition site; other site 877468009880 dimerization interface [polypeptide binding]; other site 877468009881 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 877468009882 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 877468009883 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 877468009884 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 877468009885 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 877468009886 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 877468009887 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 877468009888 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 877468009889 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 877468009890 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 877468009891 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 877468009892 4Fe-4S binding domain; Region: Fer4; pfam00037 877468009893 4Fe-4S binding domain; Region: Fer4; pfam00037 877468009894 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 877468009895 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 877468009896 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 877468009897 catalytic loop [active] 877468009898 iron binding site [ion binding]; other site 877468009899 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 877468009900 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 877468009901 [4Fe-4S] binding site [ion binding]; other site 877468009902 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 877468009903 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 877468009904 SLBB domain; Region: SLBB; pfam10531 877468009905 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 877468009906 NADH dehydrogenase subunit E; Validated; Region: PRK07539 877468009907 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 877468009908 putative dimer interface [polypeptide binding]; other site 877468009909 [2Fe-2S] cluster binding site [ion binding]; other site 877468009910 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 877468009911 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 877468009912 NADH dehydrogenase subunit D; Validated; Region: PRK06075 877468009913 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 877468009914 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 877468009915 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 877468009916 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468009917 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 877468009918 putative dimerization interface [polypeptide binding]; other site 877468009919 aminotransferase AlaT; Validated; Region: PRK09265 877468009920 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 877468009921 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468009922 homodimer interface [polypeptide binding]; other site 877468009923 catalytic residue [active] 877468009924 5'-nucleotidase; Provisional; Region: PRK03826 877468009925 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 877468009926 transmembrane helices; other site 877468009927 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 877468009928 TrkA-C domain; Region: TrkA_C; pfam02080 877468009929 TrkA-C domain; Region: TrkA_C; pfam02080 877468009930 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 877468009931 putative phosphatase; Provisional; Region: PRK11587 877468009932 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 877468009933 motif II; other site 877468009934 hypothetical protein; Validated; Region: PRK05445 877468009935 hypothetical protein; Provisional; Region: PRK01816 877468009936 propionate/acetate kinase; Provisional; Region: PRK12379 877468009937 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 877468009938 phosphate acetyltransferase; Reviewed; Region: PRK05632 877468009939 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 877468009940 DRTGG domain; Region: DRTGG; pfam07085 877468009941 phosphate acetyltransferase; Region: pta; TIGR00651 877468009942 hypothetical protein; Provisional; Region: PRK11588 877468009943 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 877468009944 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 877468009945 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 877468009946 PYR/PP interface [polypeptide binding]; other site 877468009947 dimer interface [polypeptide binding]; other site 877468009948 TPP binding site [chemical binding]; other site 877468009949 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 877468009950 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 877468009951 TPP-binding site [chemical binding]; other site 877468009952 dimer interface [polypeptide binding]; other site 877468009953 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK12996 877468009954 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 877468009955 active site 877468009956 P-loop; other site 877468009957 phosphorylation site [posttranslational modification] 877468009958 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 877468009959 active site 877468009960 phosphorylation site [posttranslational modification] 877468009961 Transcriptional regulators [Transcription]; Region: PurR; COG1609 877468009962 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 877468009963 DNA binding site [nucleotide binding] 877468009964 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 877468009965 putative dimerization interface [polypeptide binding]; other site 877468009966 putative ligand binding site [chemical binding]; other site 877468009967 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 877468009968 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 877468009969 nudix motif; other site 877468009970 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 877468009971 active site 877468009972 metal binding site [ion binding]; metal-binding site 877468009973 homotetramer interface [polypeptide binding]; other site 877468009974 glutathione S-transferase; Provisional; Region: PRK15113 877468009975 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 877468009976 C-terminal domain interface [polypeptide binding]; other site 877468009977 GSH binding site (G-site) [chemical binding]; other site 877468009978 dimer interface [polypeptide binding]; other site 877468009979 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 877468009980 N-terminal domain interface [polypeptide binding]; other site 877468009981 putative dimer interface [polypeptide binding]; other site 877468009982 putative substrate binding pocket (H-site) [chemical binding]; other site 877468009983 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 877468009984 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 877468009985 C-terminal domain interface [polypeptide binding]; other site 877468009986 GSH binding site (G-site) [chemical binding]; other site 877468009987 dimer interface [polypeptide binding]; other site 877468009988 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 877468009989 N-terminal domain interface [polypeptide binding]; other site 877468009990 putative dimer interface [polypeptide binding]; other site 877468009991 active site 877468009992 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 877468009993 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 877468009994 putative NAD(P) binding site [chemical binding]; other site 877468009995 putative active site [active] 877468009996 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 877468009997 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 877468009998 Walker A/P-loop; other site 877468009999 ATP binding site [chemical binding]; other site 877468010000 Q-loop/lid; other site 877468010001 ABC transporter signature motif; other site 877468010002 Walker B; other site 877468010003 D-loop; other site 877468010004 H-loop/switch region; other site 877468010005 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 877468010006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468010007 dimer interface [polypeptide binding]; other site 877468010008 conserved gate region; other site 877468010009 putative PBP binding loops; other site 877468010010 ABC-ATPase subunit interface; other site 877468010011 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 877468010012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468010013 dimer interface [polypeptide binding]; other site 877468010014 conserved gate region; other site 877468010015 putative PBP binding loops; other site 877468010016 ABC-ATPase subunit interface; other site 877468010017 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 877468010018 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 877468010019 substrate binding pocket [chemical binding]; other site 877468010020 membrane-bound complex binding site; other site 877468010021 hinge residues; other site 877468010022 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 877468010023 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 877468010024 substrate binding pocket [chemical binding]; other site 877468010025 membrane-bound complex binding site; other site 877468010026 hinge residues; other site 877468010027 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 877468010028 Flavoprotein; Region: Flavoprotein; pfam02441 877468010029 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 877468010030 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 877468010031 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 877468010032 dimer interface [polypeptide binding]; other site 877468010033 active site 877468010034 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 877468010035 substrate binding site [chemical binding]; other site 877468010036 catalytic residue [active] 877468010037 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 877468010038 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 877468010039 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 877468010040 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 877468010041 catalytic residue [active] 877468010042 PAS fold; Region: PAS_4; pfam08448 877468010043 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 877468010044 putative active site [active] 877468010045 heme pocket [chemical binding]; other site 877468010046 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 877468010047 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 877468010048 Walker A motif; other site 877468010049 ATP binding site [chemical binding]; other site 877468010050 Walker B motif; other site 877468010051 arginine finger; other site 877468010052 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 877468010053 amidophosphoribosyltransferase; Provisional; Region: PRK09246 877468010054 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 877468010055 active site 877468010056 tetramer interface [polypeptide binding]; other site 877468010057 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 877468010058 active site 877468010059 colicin V production protein; Provisional; Region: PRK10845 877468010060 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 877468010061 cell division protein DedD; Provisional; Region: PRK11633 877468010062 Sporulation related domain; Region: SPOR; pfam05036 877468010063 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 877468010064 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 877468010065 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 877468010066 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 877468010067 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 877468010068 hypothetical protein; Provisional; Region: PRK10847 877468010069 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 877468010070 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 877468010071 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 877468010072 dimerization interface 3.5A [polypeptide binding]; other site 877468010073 active site 877468010074 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 877468010075 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 877468010076 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 877468010077 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 877468010078 ligand binding site [chemical binding]; other site 877468010079 NAD binding site [chemical binding]; other site 877468010080 catalytic site [active] 877468010081 homodimer interface [polypeptide binding]; other site 877468010082 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 877468010083 putative transporter; Provisional; Region: PRK12382 877468010084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468010085 putative substrate translocation pore; other site 877468010086 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 877468010087 non-specific DNA binding site [nucleotide binding]; other site 877468010088 salt bridge; other site 877468010089 sequence-specific DNA binding site [nucleotide binding]; other site 877468010090 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 877468010091 CAAX protease self-immunity; Region: Abi; pfam02517 877468010092 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 877468010093 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 877468010094 dimer interface [polypeptide binding]; other site 877468010095 active site 877468010096 Uncharacterized conserved protein [Function unknown]; Region: COG4121 877468010097 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 877468010098 YfcL protein; Region: YfcL; pfam08891 877468010099 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 877468010100 hypothetical protein; Provisional; Region: PRK10621 877468010101 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 877468010102 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 877468010103 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 877468010104 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 877468010105 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 877468010106 Tetramer interface [polypeptide binding]; other site 877468010107 active site 877468010108 FMN-binding site [chemical binding]; other site 877468010109 HemK family putative methylases; Region: hemK_fam; TIGR00536 877468010110 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 877468010111 S-adenosylmethionine binding site [chemical binding]; other site 877468010112 hypothetical protein; Provisional; Region: PRK04946 877468010113 Smr domain; Region: Smr; pfam01713 877468010114 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 877468010115 catalytic core [active] 877468010116 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 877468010117 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 877468010118 substrate binding site [chemical binding]; other site 877468010119 oxyanion hole (OAH) forming residues; other site 877468010120 trimer interface [polypeptide binding]; other site 877468010121 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 877468010122 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 877468010123 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 877468010124 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 877468010125 dimer interface [polypeptide binding]; other site 877468010126 active site 877468010127 Protein of unknown function (DUF406); Region: DUF406; cl11449 877468010128 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 877468010129 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 877468010130 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 877468010131 outer membrane protease; Reviewed; Region: PRK10993 877468010132 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 877468010133 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 877468010134 active site 877468010135 phosphorylation site [posttranslational modification] 877468010136 intermolecular recognition site; other site 877468010137 dimerization interface [polypeptide binding]; other site 877468010138 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 877468010139 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 877468010140 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 877468010141 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 877468010142 dimerization interface [polypeptide binding]; other site 877468010143 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 877468010144 dimer interface [polypeptide binding]; other site 877468010145 phosphorylation site [posttranslational modification] 877468010146 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 877468010147 ATP binding site [chemical binding]; other site 877468010148 Mg2+ binding site [ion binding]; other site 877468010149 G-X-G motif; other site 877468010150 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 877468010151 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 877468010152 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 877468010153 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468010154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468010155 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 877468010156 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 877468010157 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 877468010158 putative acyl-acceptor binding pocket; other site 877468010159 aminotransferase; Validated; Region: PRK08175 877468010160 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 877468010161 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468010162 homodimer interface [polypeptide binding]; other site 877468010163 catalytic residue [active] 877468010164 glucokinase; Provisional; Region: glk; PRK00292 877468010165 glucokinase, proteobacterial type; Region: glk; TIGR00749 877468010166 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 877468010167 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 877468010168 Cl- selectivity filter; other site 877468010169 Cl- binding residues [ion binding]; other site 877468010170 pore gating glutamate residue; other site 877468010171 dimer interface [polypeptide binding]; other site 877468010172 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 877468010173 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 877468010174 dimer interface [polypeptide binding]; other site 877468010175 PYR/PP interface [polypeptide binding]; other site 877468010176 TPP binding site [chemical binding]; other site 877468010177 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 877468010178 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 877468010179 TPP-binding site [chemical binding]; other site 877468010180 dimer interface [polypeptide binding]; other site 877468010181 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 877468010182 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 877468010183 active site 877468010184 catalytic tetrad [active] 877468010185 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 877468010186 manganese transport protein MntH; Reviewed; Region: PRK00701 877468010187 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 877468010188 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 877468010189 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 877468010190 Nucleoside recognition; Region: Gate; pfam07670 877468010191 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 877468010192 MASE1; Region: MASE1; pfam05231 877468010193 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 877468010194 diguanylate cyclase; Region: GGDEF; smart00267 877468010195 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 877468010196 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 877468010197 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 877468010198 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 877468010199 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 877468010200 active site 877468010201 HIGH motif; other site 877468010202 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 877468010203 active site 877468010204 KMSKS motif; other site 877468010205 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 877468010206 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468010207 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 877468010208 putative dimerization interface [polypeptide binding]; other site 877468010209 putative substrate binding pocket [chemical binding]; other site 877468010210 XapX domain; Region: XapX; TIGR03510 877468010211 nucleoside transporter; Region: 2A0110; TIGR00889 877468010212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468010213 putative substrate translocation pore; other site 877468010214 purine nucleoside phosphorylase; Provisional; Region: PRK08202 877468010215 hypothetical protein; Provisional; Region: PRK11528 877468010216 Transcriptional regulator [Transcription]; Region: LysR; COG0583 877468010217 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468010218 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 877468010219 putative dimerization interface [polypeptide binding]; other site 877468010220 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 877468010221 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 877468010222 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 877468010223 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 877468010224 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 877468010225 nucleotide binding pocket [chemical binding]; other site 877468010226 K-X-D-G motif; other site 877468010227 catalytic site [active] 877468010228 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 877468010229 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 877468010230 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 877468010231 Dimer interface [polypeptide binding]; other site 877468010232 BRCT sequence motif; other site 877468010233 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 877468010234 cell division protein ZipA; Provisional; Region: PRK03427 877468010235 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 877468010236 FtsZ protein binding site [polypeptide binding]; other site 877468010237 putative sulfate transport protein CysZ; Validated; Region: PRK04949 877468010238 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 877468010239 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 877468010240 dimer interface [polypeptide binding]; other site 877468010241 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468010242 catalytic residue [active] 877468010243 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 877468010244 dimerization domain swap beta strand [polypeptide binding]; other site 877468010245 regulatory protein interface [polypeptide binding]; other site 877468010246 active site 877468010247 regulatory phosphorylation site [posttranslational modification]; other site 877468010248 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 877468010249 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 877468010250 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 877468010251 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 877468010252 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 877468010253 HPr interaction site; other site 877468010254 glycerol kinase (GK) interaction site [polypeptide binding]; other site 877468010255 active site 877468010256 phosphorylation site [posttranslational modification] 877468010257 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 877468010258 dimer interface [polypeptide binding]; other site 877468010259 pyridoxamine kinase; Validated; Region: PRK05756 877468010260 pyridoxal binding site [chemical binding]; other site 877468010261 ATP binding site [chemical binding]; other site 877468010262 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 877468010263 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 877468010264 DNA-binding site [nucleotide binding]; DNA binding site 877468010265 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 877468010266 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468010267 homodimer interface [polypeptide binding]; other site 877468010268 catalytic residue [active] 877468010269 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 877468010270 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 877468010271 catalytic triad [active] 877468010272 hypothetical protein; Provisional; Region: PRK10318 877468010273 Transglycosylase; Region: Transgly; cl17702 877468010274 cysteine synthase B; Region: cysM; TIGR01138 877468010275 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 877468010276 dimer interface [polypeptide binding]; other site 877468010277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468010278 catalytic residue [active] 877468010279 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 877468010280 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 877468010281 Walker A/P-loop; other site 877468010282 ATP binding site [chemical binding]; other site 877468010283 Q-loop/lid; other site 877468010284 ABC transporter signature motif; other site 877468010285 Walker B; other site 877468010286 D-loop; other site 877468010287 H-loop/switch region; other site 877468010288 TOBE-like domain; Region: TOBE_3; pfam12857 877468010289 sulfate transport protein; Provisional; Region: cysT; CHL00187 877468010290 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468010291 dimer interface [polypeptide binding]; other site 877468010292 conserved gate region; other site 877468010293 putative PBP binding loops; other site 877468010294 ABC-ATPase subunit interface; other site 877468010295 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 877468010296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468010297 dimer interface [polypeptide binding]; other site 877468010298 conserved gate region; other site 877468010299 putative PBP binding loops; other site 877468010300 ABC-ATPase subunit interface; other site 877468010301 thiosulfate transporter subunit; Provisional; Region: PRK10852 877468010302 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 877468010303 short chain dehydrogenase; Provisional; Region: PRK08226 877468010304 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 877468010305 NAD binding site [chemical binding]; other site 877468010306 homotetramer interface [polypeptide binding]; other site 877468010307 homodimer interface [polypeptide binding]; other site 877468010308 active site 877468010309 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 877468010310 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 877468010311 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 877468010312 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 877468010313 putative acetyltransferase; Provisional; Region: PRK03624 877468010314 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 877468010315 Coenzyme A binding pocket [chemical binding]; other site 877468010316 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 877468010317 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 877468010318 active site 877468010319 metal binding site [ion binding]; metal-binding site 877468010320 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 877468010321 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 877468010322 transcriptional regulator EutR; Provisional; Region: PRK10130 877468010323 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 877468010324 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 877468010325 carboxysome structural protein EutK; Provisional; Region: PRK15466 877468010326 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 877468010327 Hexamer interface [polypeptide binding]; other site 877468010328 Hexagonal pore residue; other site 877468010329 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 877468010330 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 877468010331 putative hexamer interface [polypeptide binding]; other site 877468010332 putative hexagonal pore; other site 877468010333 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 877468010334 putative hexamer interface [polypeptide binding]; other site 877468010335 putative hexagonal pore; other site 877468010336 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 877468010337 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 877468010338 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 877468010339 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 877468010340 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 877468010341 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 877468010342 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 877468010343 active site 877468010344 metal binding site [ion binding]; metal-binding site 877468010345 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 877468010346 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 877468010347 nucleotide binding site [chemical binding]; other site 877468010348 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 877468010349 putative catalytic cysteine [active] 877468010350 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 877468010351 Hexamer/Pentamer interface [polypeptide binding]; other site 877468010352 central pore; other site 877468010353 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 877468010354 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 877468010355 Hexamer interface [polypeptide binding]; other site 877468010356 Putative hexagonal pore residue; other site 877468010357 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 877468010358 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 877468010359 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 877468010360 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 877468010361 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 877468010362 G1 box; other site 877468010363 GTP/Mg2+ binding site [chemical binding]; other site 877468010364 G2 box; other site 877468010365 Switch I region; other site 877468010366 G3 box; other site 877468010367 Switch II region; other site 877468010368 G4 box; other site 877468010369 G5 box; other site 877468010370 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 877468010371 putative hexamer interface [polypeptide binding]; other site 877468010372 putative hexagonal pore; other site 877468010373 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 877468010374 Malic enzyme, N-terminal domain; Region: malic; pfam00390 877468010375 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 877468010376 putative NAD(P) binding site [chemical binding]; other site 877468010377 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 877468010378 transaldolase-like protein; Provisional; Region: PTZ00411 877468010379 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 877468010380 active site 877468010381 dimer interface [polypeptide binding]; other site 877468010382 catalytic residue [active] 877468010383 transketolase; Reviewed; Region: PRK12753 877468010384 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 877468010385 TPP-binding site [chemical binding]; other site 877468010386 dimer interface [polypeptide binding]; other site 877468010387 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 877468010388 PYR/PP interface [polypeptide binding]; other site 877468010389 dimer interface [polypeptide binding]; other site 877468010390 TPP binding site [chemical binding]; other site 877468010391 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 877468010392 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 877468010393 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 877468010394 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 877468010395 dimer interface [polypeptide binding]; other site 877468010396 ADP-ribose binding site [chemical binding]; other site 877468010397 active site 877468010398 nudix motif; other site 877468010399 metal binding site [ion binding]; metal-binding site 877468010400 putative periplasmic esterase; Provisional; Region: PRK03642 877468010401 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 877468010402 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 877468010403 4Fe-4S binding domain; Region: Fer4; pfam00037 877468010404 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 877468010405 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 877468010406 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 877468010407 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 877468010408 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 877468010409 dimerization interface [polypeptide binding]; other site 877468010410 Histidine kinase; Region: HisKA_3; pfam07730 877468010411 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 877468010412 ATP binding site [chemical binding]; other site 877468010413 Mg2+ binding site [ion binding]; other site 877468010414 G-X-G motif; other site 877468010415 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 877468010416 Protein export membrane protein; Region: SecD_SecF; cl14618 877468010417 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 877468010418 ArsC family; Region: ArsC; pfam03960 877468010419 putative catalytic residues [active] 877468010420 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 877468010421 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 877468010422 metal binding site [ion binding]; metal-binding site 877468010423 dimer interface [polypeptide binding]; other site 877468010424 hypothetical protein; Provisional; Region: PRK13664 877468010425 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 877468010426 Helicase; Region: Helicase_RecD; pfam05127 877468010427 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 877468010428 Coenzyme A binding pocket [chemical binding]; other site 877468010429 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 877468010430 Predicted metalloprotease [General function prediction only]; Region: COG2321 877468010431 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 877468010432 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 877468010433 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 877468010434 ATP binding site [chemical binding]; other site 877468010435 active site 877468010436 substrate binding site [chemical binding]; other site 877468010437 lipoprotein; Provisional; Region: PRK11679 877468010438 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 877468010439 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 877468010440 dihydrodipicolinate synthase; Region: dapA; TIGR00674 877468010441 dimer interface [polypeptide binding]; other site 877468010442 active site 877468010443 catalytic residue [active] 877468010444 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 877468010445 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 877468010446 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 877468010447 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 877468010448 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 877468010449 catalytic triad [active] 877468010450 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 877468010451 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 877468010452 fructuronate transporter; Provisional; Region: PRK10034; cl15264 877468010453 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 877468010454 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 877468010455 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 877468010456 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 877468010457 Domain of unknown function DUF20; Region: UPF0118; pfam01594 877468010458 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 877468010459 Peptidase family M48; Region: Peptidase_M48; cl12018 877468010460 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 877468010461 ArsC family; Region: ArsC; pfam03960 877468010462 catalytic residues [active] 877468010463 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 877468010464 DNA replication initiation factor; Provisional; Region: PRK08084 877468010465 uracil transporter; Provisional; Region: PRK10720 877468010466 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 877468010467 active site 877468010468 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 877468010469 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 877468010470 dimerization interface [polypeptide binding]; other site 877468010471 putative ATP binding site [chemical binding]; other site 877468010472 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 877468010473 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 877468010474 active site 877468010475 substrate binding site [chemical binding]; other site 877468010476 cosubstrate binding site; other site 877468010477 catalytic site [active] 877468010478 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 877468010479 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 877468010480 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 877468010481 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 877468010482 putative active site [active] 877468010483 catalytic site [active] 877468010484 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 877468010485 domain interface [polypeptide binding]; other site 877468010486 active site 877468010487 catalytic site [active] 877468010488 exopolyphosphatase; Provisional; Region: PRK10854 877468010489 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 877468010490 nucleotide binding site [chemical binding]; other site 877468010491 MASE1; Region: MASE1; pfam05231 877468010492 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 877468010493 diguanylate cyclase; Region: GGDEF; smart00267 877468010494 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 877468010495 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 877468010496 Integrase core domain; Region: rve; pfam00665 877468010497 GMP synthase; Reviewed; Region: guaA; PRK00074 877468010498 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 877468010499 AMP/PPi binding site [chemical binding]; other site 877468010500 candidate oxyanion hole; other site 877468010501 catalytic triad [active] 877468010502 potential glutamine specificity residues [chemical binding]; other site 877468010503 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 877468010504 ATP Binding subdomain [chemical binding]; other site 877468010505 Ligand Binding sites [chemical binding]; other site 877468010506 Dimerization subdomain; other site 877468010507 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 877468010508 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 877468010509 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 877468010510 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 877468010511 active site 877468010512 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 877468010513 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 877468010514 generic binding surface II; other site 877468010515 generic binding surface I; other site 877468010516 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 877468010517 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 877468010518 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 877468010519 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 877468010520 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 877468010521 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 877468010522 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 877468010523 Autotransporter beta-domain; Region: Autotransporter; smart00869 877468010524 outer membrane protein RatB; Provisional; Region: PRK15314 877468010525 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 877468010526 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 877468010527 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 877468010528 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 877468010529 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 877468010530 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 877468010531 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 877468010532 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 877468010533 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 877468010534 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 877468010535 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 877468010536 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 877468010537 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 877468010538 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 877468010539 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 877468010540 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 877468010541 outer membrane protein RatA; Provisional; Region: PRK15315 877468010542 Oxygen tolerance; Region: BatD; pfam13584 877468010543 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 877468010544 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 877468010545 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 877468010546 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 877468010547 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 877468010548 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 877468010549 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 877468010550 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 877468010551 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 877468010552 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 877468010553 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 877468010554 intimin-like protein SinH; Provisional; Region: PRK15318 877468010555 intimin-like protein SinH; Provisional; Region: PRK15318 877468010556 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 877468010557 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 877468010558 GTP-binding protein Der; Reviewed; Region: PRK00093 877468010559 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 877468010560 G1 box; other site 877468010561 GTP/Mg2+ binding site [chemical binding]; other site 877468010562 Switch I region; other site 877468010563 G2 box; other site 877468010564 Switch II region; other site 877468010565 G3 box; other site 877468010566 G4 box; other site 877468010567 G5 box; other site 877468010568 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 877468010569 G1 box; other site 877468010570 GTP/Mg2+ binding site [chemical binding]; other site 877468010571 Switch I region; other site 877468010572 G2 box; other site 877468010573 G3 box; other site 877468010574 Switch II region; other site 877468010575 G4 box; other site 877468010576 G5 box; other site 877468010577 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 877468010578 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 877468010579 Trp docking motif [polypeptide binding]; other site 877468010580 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 877468010581 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 877468010582 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 877468010583 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 877468010584 dimer interface [polypeptide binding]; other site 877468010585 motif 1; other site 877468010586 active site 877468010587 motif 2; other site 877468010588 motif 3; other site 877468010589 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 877468010590 anticodon binding site; other site 877468010591 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 877468010592 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 877468010593 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 877468010594 cytoskeletal protein RodZ; Provisional; Region: PRK10856 877468010595 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 877468010596 non-specific DNA binding site [nucleotide binding]; other site 877468010597 salt bridge; other site 877468010598 sequence-specific DNA binding site [nucleotide binding]; other site 877468010599 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 877468010600 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 877468010601 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 877468010602 FeS/SAM binding site; other site 877468010603 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 877468010604 active site 877468010605 multimer interface [polypeptide binding]; other site 877468010606 4Fe-4S binding domain; Region: Fer4; pfam00037 877468010607 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 877468010608 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 877468010609 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 877468010610 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 877468010611 4Fe-4S binding domain; Region: Fer4; pfam00037 877468010612 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 877468010613 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 877468010614 putative [Fe4-S4] binding site [ion binding]; other site 877468010615 putative molybdopterin cofactor binding site [chemical binding]; other site 877468010616 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 877468010617 putative molybdopterin cofactor binding site; other site 877468010618 penicillin-binding protein 1C; Provisional; Region: PRK11240 877468010619 Transglycosylase; Region: Transgly; pfam00912 877468010620 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 877468010621 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 877468010622 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 877468010623 MG2 domain; Region: A2M_N; pfam01835 877468010624 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 877468010625 surface patch; other site 877468010626 thioester region; other site 877468010627 specificity defining residues; other site 877468010628 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 877468010629 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 877468010630 active site residue [active] 877468010631 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 877468010632 active site residue [active] 877468010633 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 877468010634 aminopeptidase B; Provisional; Region: PRK05015 877468010635 Peptidase; Region: DUF3663; pfam12404 877468010636 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 877468010637 interface (dimer of trimers) [polypeptide binding]; other site 877468010638 Substrate-binding/catalytic site; other site 877468010639 Zn-binding sites [ion binding]; other site 877468010640 hypothetical protein; Provisional; Region: PRK10721 877468010641 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 877468010642 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 877468010643 catalytic loop [active] 877468010644 iron binding site [ion binding]; other site 877468010645 chaperone protein HscA; Provisional; Region: hscA; PRK05183 877468010646 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 877468010647 nucleotide binding site [chemical binding]; other site 877468010648 putative NEF/HSP70 interaction site [polypeptide binding]; other site 877468010649 SBD interface [polypeptide binding]; other site 877468010650 co-chaperone HscB; Provisional; Region: hscB; PRK05014 877468010651 DnaJ domain; Region: DnaJ; pfam00226 877468010652 HSP70 interaction site [polypeptide binding]; other site 877468010653 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 877468010654 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 877468010655 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 877468010656 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 877468010657 trimerization site [polypeptide binding]; other site 877468010658 active site 877468010659 cysteine desulfurase; Provisional; Region: PRK14012 877468010660 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 877468010661 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 877468010662 catalytic residue [active] 877468010663 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 877468010664 Rrf2 family protein; Region: rrf2_super; TIGR00738 877468010665 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 877468010666 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 877468010667 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 877468010668 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 877468010669 active site 877468010670 dimerization interface [polypeptide binding]; other site 877468010671 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 877468010672 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 877468010673 sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910 877468010674 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 877468010675 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 877468010676 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 877468010677 FAD binding pocket [chemical binding]; other site 877468010678 FAD binding motif [chemical binding]; other site 877468010679 phosphate binding motif [ion binding]; other site 877468010680 beta-alpha-beta structure motif; other site 877468010681 NAD binding pocket [chemical binding]; other site 877468010682 Iron coordination center [ion binding]; other site 877468010683 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 877468010684 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 877468010685 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 877468010686 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 877468010687 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 877468010688 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 877468010689 PRD domain; Region: PRD; pfam00874 877468010690 PRD domain; Region: PRD; pfam00874 877468010691 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 877468010692 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468010693 putative substrate translocation pore; other site 877468010694 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 877468010695 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 877468010696 dimer interface [polypeptide binding]; other site 877468010697 active site 877468010698 glycine-pyridoxal phosphate binding site [chemical binding]; other site 877468010699 folate binding site [chemical binding]; other site 877468010700 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 877468010701 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 877468010702 heme-binding site [chemical binding]; other site 877468010703 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 877468010704 FAD binding pocket [chemical binding]; other site 877468010705 FAD binding motif [chemical binding]; other site 877468010706 phosphate binding motif [ion binding]; other site 877468010707 beta-alpha-beta structure motif; other site 877468010708 NAD binding pocket [chemical binding]; other site 877468010709 Heme binding pocket [chemical binding]; other site 877468010710 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 877468010711 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 877468010712 DNA binding site [nucleotide binding] 877468010713 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 877468010714 lysine decarboxylase CadA; Provisional; Region: PRK15400 877468010715 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 877468010716 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 877468010717 homodimer interface [polypeptide binding]; other site 877468010718 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468010719 catalytic residue [active] 877468010720 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 877468010721 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 877468010722 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468010723 putative substrate translocation pore; other site 877468010724 POT family; Region: PTR2; pfam00854 877468010725 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 877468010726 Nitrogen regulatory protein P-II; Region: P-II; smart00938 877468010727 response regulator GlrR; Provisional; Region: PRK15115 877468010728 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 877468010729 active site 877468010730 phosphorylation site [posttranslational modification] 877468010731 intermolecular recognition site; other site 877468010732 dimerization interface [polypeptide binding]; other site 877468010733 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 877468010734 Walker A motif; other site 877468010735 ATP binding site [chemical binding]; other site 877468010736 Walker B motif; other site 877468010737 arginine finger; other site 877468010738 hypothetical protein; Provisional; Region: PRK10722 877468010739 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 877468010740 HAMP domain; Region: HAMP; pfam00672 877468010741 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 877468010742 dimer interface [polypeptide binding]; other site 877468010743 phosphorylation site [posttranslational modification] 877468010744 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 877468010745 ATP binding site [chemical binding]; other site 877468010746 Mg2+ binding site [ion binding]; other site 877468010747 G-X-G motif; other site 877468010748 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 877468010749 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 877468010750 dimerization interface [polypeptide binding]; other site 877468010751 ATP binding site [chemical binding]; other site 877468010752 Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of...; Region: PurL; cd02193 877468010753 dimerization interface [polypeptide binding]; other site 877468010754 ATP binding site [chemical binding]; other site 877468010755 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 877468010756 putative active site [active] 877468010757 catalytic triad [active] 877468010758 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 877468010759 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 877468010760 substrate binding pocket [chemical binding]; other site 877468010761 membrane-bound complex binding site; other site 877468010762 hinge residues; other site 877468010763 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 877468010764 N-acetyl-D-glucosamine binding site [chemical binding]; other site 877468010765 catalytic residue [active] 877468010766 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 877468010767 nucleoside/Zn binding site; other site 877468010768 dimer interface [polypeptide binding]; other site 877468010769 catalytic motif [active] 877468010770 hypothetical protein; Provisional; Region: PRK11590 877468010771 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 877468010772 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 877468010773 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 877468010774 active site turn [active] 877468010775 phosphorylation site [posttranslational modification] 877468010776 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 877468010777 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 877468010778 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 877468010779 putative active site [active] 877468010780 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 877468010781 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 877468010782 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 877468010783 putative active site [active] 877468010784 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 877468010785 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 877468010786 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 877468010787 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468010788 Major Facilitator Superfamily; Region: MFS_1; pfam07690 877468010789 putative substrate translocation pore; other site 877468010790 Transcriptional regulator [Transcription]; Region: LysR; COG0583 877468010791 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468010792 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 877468010793 dimerization interface [polypeptide binding]; other site 877468010794 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 877468010795 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 877468010796 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 877468010797 active site 877468010798 hydrophilic channel; other site 877468010799 dimerization interface [polypeptide binding]; other site 877468010800 catalytic residues [active] 877468010801 active site lid [active] 877468010802 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 877468010803 Recombination protein O N terminal; Region: RecO_N; pfam11967 877468010804 Recombination protein O C terminal; Region: RecO_C; pfam02565 877468010805 GTPase Era; Reviewed; Region: era; PRK00089 877468010806 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 877468010807 G1 box; other site 877468010808 GTP/Mg2+ binding site [chemical binding]; other site 877468010809 Switch I region; other site 877468010810 G2 box; other site 877468010811 Switch II region; other site 877468010812 G3 box; other site 877468010813 G4 box; other site 877468010814 G5 box; other site 877468010815 KH domain; Region: KH_2; pfam07650 877468010816 ribonuclease III; Reviewed; Region: rnc; PRK00102 877468010817 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 877468010818 dimerization interface [polypeptide binding]; other site 877468010819 active site 877468010820 metal binding site [ion binding]; metal-binding site 877468010821 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 877468010822 dsRNA binding site [nucleotide binding]; other site 877468010823 signal peptidase I; Provisional; Region: PRK10861 877468010824 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 877468010825 Catalytic site [active] 877468010826 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 877468010827 GTP-binding protein LepA; Provisional; Region: PRK05433 877468010828 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 877468010829 G1 box; other site 877468010830 putative GEF interaction site [polypeptide binding]; other site 877468010831 GTP/Mg2+ binding site [chemical binding]; other site 877468010832 Switch I region; other site 877468010833 G2 box; other site 877468010834 G3 box; other site 877468010835 Switch II region; other site 877468010836 G4 box; other site 877468010837 G5 box; other site 877468010838 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 877468010839 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 877468010840 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 877468010841 type III secretion protein GogB; Provisional; Region: PRK15386 877468010842 Integrase core domain; Region: rve_3; cl15866 877468010843 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 877468010844 Macro domain, Appr-1"-pase family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase; cd02900 877468010845 ADP-ribose binding site [chemical binding]; other site 877468010846 putative active site [active] 877468010847 dimer interface [polypeptide binding]; other site 877468010848 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 877468010849 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 877468010850 Phage Tail Collar Domain; Region: Collar; pfam07484 877468010851 Phage-related protein, tail component [Function unknown]; Region: COG4733 877468010852 Putative phage tail protein; Region: Phage-tail_3; pfam13550 877468010853 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 877468010854 Interdomain contacts; other site 877468010855 Cytokine receptor motif; other site 877468010856 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 877468010857 Fibronectin type III protein; Region: DUF3672; pfam12421 877468010858 Phage-related protein, tail component [Function unknown]; Region: COG4723 877468010859 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 877468010860 MPN+ (JAMM) motif; other site 877468010861 Zinc-binding site [ion binding]; other site 877468010862 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 877468010863 NlpC/P60 family; Region: NLPC_P60; cl17555 877468010864 Phage-related protein [Function unknown]; Region: gp18; COG4672 877468010865 Phage-related protein [Function unknown]; Region: COG4718 877468010866 Phage-related minor tail protein [Function unknown]; Region: COG5281 877468010867 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 877468010868 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 877468010869 Minor tail protein T; Region: Phage_tail_T; cl05636 877468010870 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 877468010871 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 877468010872 Phage tail protein; Region: Phage_tail_3; pfam08813 877468010873 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 877468010874 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 877468010875 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 877468010876 Probable transposase; Region: OrfB_IS605; pfam01385 877468010877 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 877468010878 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 877468010879 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; cl05094 877468010880 DNA packaging protein FI; Region: Packaging_FI; pfam14000 877468010881 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 877468010882 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 877468010883 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 877468010884 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 877468010885 tandem repeat interface [polypeptide binding]; other site 877468010886 oligomer interface [polypeptide binding]; other site 877468010887 active site residues [active] 877468010888 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 877468010889 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 877468010890 gpW; Region: gpW; pfam02831 877468010891 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 877468010892 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 877468010893 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 877468010894 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 877468010895 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 877468010896 catalytic residues [active] 877468010897 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 877468010898 PipA protein; Region: PipA; pfam07108 877468010899 ORF6N domain; Region: ORF6N; pfam10543 877468010900 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 877468010901 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 877468010902 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 877468010903 DinI-like family; Region: DinI; pfam06183 877468010904 Protein of unknown function (DUF550); Region: DUF550; pfam04447 877468010905 Replication protein P; Region: Phage_lambda_P; pfam06992 877468010906 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 877468010907 AAA domain; Region: AAA_31; pfam13614 877468010908 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 877468010909 P-loop; other site 877468010910 Magnesium ion binding site [ion binding]; other site 877468010911 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 877468010912 Magnesium ion binding site [ion binding]; other site 877468010913 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 877468010914 exonuclease VIII; Reviewed; Region: PRK09709 877468010915 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 877468010916 RecT family; Region: RecT; pfam03837 877468010917 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 877468010918 integrase; Provisional; Region: PRK09692 877468010919 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 877468010920 active site 877468010921 Int/Topo IB signature motif; other site 877468010922 SoxR reducing system protein RseC; Provisional; Region: PRK10862 877468010923 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 877468010924 anti-sigma E factor; Provisional; Region: rseB; PRK09455 877468010925 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 877468010926 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 877468010927 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 877468010928 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 877468010929 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 877468010930 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 877468010931 DNA binding residues [nucleotide binding] 877468010932 L-aspartate oxidase; Provisional; Region: PRK09077 877468010933 L-aspartate oxidase; Provisional; Region: PRK06175 877468010934 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 877468010935 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 877468010936 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 877468010937 S-adenosylmethionine binding site [chemical binding]; other site 877468010938 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 877468010939 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 877468010940 ATP binding site [chemical binding]; other site 877468010941 Mg++ binding site [ion binding]; other site 877468010942 motif III; other site 877468010943 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 877468010944 nucleotide binding region [chemical binding]; other site 877468010945 ATP-binding site [chemical binding]; other site 877468010946 Transcriptional regulator [Transcription]; Region: LysR; COG0583 877468010947 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468010948 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 877468010949 dimerization interface [polypeptide binding]; other site 877468010950 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 877468010951 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 877468010952 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 877468010953 ligand binding site [chemical binding]; other site 877468010954 active site 877468010955 UGI interface [polypeptide binding]; other site 877468010956 catalytic site [active] 877468010957 putative methyltransferase; Provisional; Region: PRK10864 877468010958 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 877468010959 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 877468010960 thioredoxin 2; Provisional; Region: PRK10996 877468010961 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 877468010962 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 877468010963 catalytic residues [active] 877468010964 Uncharacterized conserved protein [Function unknown]; Region: COG3148 877468010965 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 877468010966 CoA binding domain; Region: CoA_binding_2; pfam13380 877468010967 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 877468010968 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 877468010969 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 877468010970 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 877468010971 Coenzyme A binding pocket [chemical binding]; other site 877468010972 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 877468010973 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 877468010974 domain interface [polypeptide binding]; other site 877468010975 putative active site [active] 877468010976 catalytic site [active] 877468010977 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 877468010978 domain interface [polypeptide binding]; other site 877468010979 putative active site [active] 877468010980 catalytic site [active] 877468010981 lipoprotein; Provisional; Region: PRK10759 877468010982 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 877468010983 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468010984 putative substrate translocation pore; other site 877468010985 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 877468010986 protein disaggregation chaperone; Provisional; Region: PRK10865 877468010987 Clp amino terminal domain; Region: Clp_N; pfam02861 877468010988 Clp amino terminal domain; Region: Clp_N; pfam02861 877468010989 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 877468010990 Walker A motif; other site 877468010991 ATP binding site [chemical binding]; other site 877468010992 Walker B motif; other site 877468010993 arginine finger; other site 877468010994 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 877468010995 Walker A motif; other site 877468010996 ATP binding site [chemical binding]; other site 877468010997 Walker B motif; other site 877468010998 arginine finger; other site 877468010999 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 877468011000 hypothetical protein; Provisional; Region: PRK10723 877468011001 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 877468011002 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 877468011003 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 877468011004 RNA binding surface [nucleotide binding]; other site 877468011005 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 877468011006 active site 877468011007 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 877468011008 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 877468011009 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 877468011010 30S subunit binding site; other site 877468011011 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 877468011012 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 877468011013 Prephenate dehydratase; Region: PDT; pfam00800 877468011014 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 877468011015 putative L-Phe binding site [chemical binding]; other site 877468011016 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 877468011017 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 877468011018 Chorismate mutase type II; Region: CM_2; cl00693 877468011019 prephenate dehydrogenase; Validated; Region: PRK08507 877468011020 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 877468011021 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 877468011022 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 877468011023 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 877468011024 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 877468011025 metal binding site [ion binding]; metal-binding site 877468011026 active site 877468011027 I-site; other site 877468011028 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 877468011029 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 877468011030 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 877468011031 RimM N-terminal domain; Region: RimM; pfam01782 877468011032 PRC-barrel domain; Region: PRC; pfam05239 877468011033 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 877468011034 signal recognition particle protein; Provisional; Region: PRK10867 877468011035 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 877468011036 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 877468011037 P loop; other site 877468011038 GTP binding site [chemical binding]; other site 877468011039 Signal peptide binding domain; Region: SRP_SPB; pfam02978 877468011040 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 877468011041 hypothetical protein; Provisional; Region: PRK11573 877468011042 Domain of unknown function DUF21; Region: DUF21; pfam01595 877468011043 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 877468011044 Transporter associated domain; Region: CorC_HlyC; smart01091 877468011045 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 877468011046 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 877468011047 dimer interface [polypeptide binding]; other site 877468011048 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 877468011049 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 877468011050 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 877468011051 recombination and repair protein; Provisional; Region: PRK10869 877468011052 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 877468011053 Walker A/P-loop; other site 877468011054 ATP binding site [chemical binding]; other site 877468011055 Q-loop/lid; other site 877468011056 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 877468011057 ABC transporter signature motif; other site 877468011058 Walker B; other site 877468011059 D-loop; other site 877468011060 H-loop/switch region; other site 877468011061 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 877468011062 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 877468011063 hypothetical protein; Validated; Region: PRK01777 877468011064 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 877468011065 putative coenzyme Q binding site [chemical binding]; other site 877468011066 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 877468011067 SmpB-tmRNA interface; other site 877468011068 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 877468011069 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 877468011070 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 877468011071 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 877468011072 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 877468011073 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 877468011074 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 877468011075 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 877468011076 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 877468011077 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 877468011078 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 877468011079 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 877468011080 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 877468011081 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 877468011082 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 877468011083 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 877468011084 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 877468011085 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 877468011086 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 877468011087 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 877468011088 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 877468011089 Walker A/P-loop; other site 877468011090 ATP binding site [chemical binding]; other site 877468011091 Q-loop/lid; other site 877468011092 ABC transporter signature motif; other site 877468011093 Walker B; other site 877468011094 D-loop; other site 877468011095 H-loop/switch region; other site 877468011096 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 877468011097 HlyD family secretion protein; Region: HlyD_3; pfam13437 877468011098 baseplate hub subunit and tail lysozyme; Provisional; Region: 5; PHA02596 877468011099 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 877468011100 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 877468011101 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 877468011102 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 877468011103 Baseplate J-like protein; Region: Baseplate_J; cl01294 877468011104 Baseplate J-like protein; Region: Baseplate_J; pfam04865 877468011105 Protein of unknown function (DUF2590); Region: DUF2590; pfam10761 877468011106 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 877468011107 Protein of unknown function (DUF2765); Region: DUF2765; pfam10963 877468011108 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 877468011109 Phage holin family 2; Region: Phage_holin_2; pfam04550 877468011110 Protein of unknown function (DUF2597); Region: DUF2597; pfam10772 877468011111 Protein of unknown function (DUF2586); Region: DUF2586; pfam10758 877468011112 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 877468011113 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 877468011114 terminase endonuclease subunit; Provisional; Region: M; PHA02537 877468011115 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 877468011116 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 877468011117 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 877468011118 terminase ATPase subunit; Provisional; Region: P; PHA02535 877468011119 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 877468011120 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 877468011121 Phage-related protein [Function unknown]; Region: COG4695; cl01923 877468011122 Phage portal protein; Region: Phage_portal; pfam04860 877468011123 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 877468011124 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 877468011125 Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961 877468011126 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 877468011127 threonine ammonia-lyase, medium form; Region: ilvA_1Cterm; TIGR01127 877468011128 Protein of unknown function (DUF2724); Region: DUF2724; pfam10893 877468011129 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 877468011130 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 877468011131 integrase; Provisional; Region: int; PHA02601 877468011132 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 877468011133 active site 877468011134 DNA binding site [nucleotide binding] 877468011135 Int/Topo IB signature motif; other site 877468011136 integrase; Provisional; Region: PRK09692 877468011137 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 877468011138 active site 877468011139 Int/Topo IB signature motif; other site 877468011140 Domain of unknown function DUF87; Region: DUF87; pfam01935 877468011141 HerA helicase [Replication, recombination, and repair]; Region: COG0433 877468011142 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 877468011143 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 877468011144 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 877468011145 Ash protein family; Region: Phage_ASH; pfam10554 877468011146 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 877468011147 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 877468011148 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 877468011149 active site 877468011150 metal binding site [ion binding]; metal-binding site 877468011151 interdomain interaction site; other site 877468011152 D5 N terminal like; Region: D5_N; smart00885 877468011153 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 877468011154 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 877468011155 Repressor of phase-1 flagellin; Region: Flag1_repress; pfam03614 877468011156 flagellin; Validated; Region: PRK08026 877468011157 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 877468011158 Flagellin D3 domain; Region: Flagellin_D3; pfam08884 877468011159 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 877468011160 multiple promoter invertase; Provisional; Region: mpi; PRK13413 877468011161 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 877468011162 catalytic residues [active] 877468011163 catalytic nucleophile [active] 877468011164 Presynaptic Site I dimer interface [polypeptide binding]; other site 877468011165 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 877468011166 Synaptic Flat tetramer interface [polypeptide binding]; other site 877468011167 Synaptic Site I dimer interface [polypeptide binding]; other site 877468011168 DNA binding site [nucleotide binding] 877468011169 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 877468011170 DNA-binding interface [nucleotide binding]; DNA binding site 877468011171 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 877468011172 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 877468011173 homodimer interface [polypeptide binding]; other site 877468011174 active site 877468011175 TDP-binding site; other site 877468011176 acceptor substrate-binding pocket; other site 877468011177 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 877468011178 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 877468011179 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 877468011180 Walker A/P-loop; other site 877468011181 ATP binding site [chemical binding]; other site 877468011182 Q-loop/lid; other site 877468011183 ABC transporter signature motif; other site 877468011184 Walker B; other site 877468011185 D-loop; other site 877468011186 H-loop/switch region; other site 877468011187 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 877468011188 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 877468011189 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 877468011190 Walker A/P-loop; other site 877468011191 ATP binding site [chemical binding]; other site 877468011192 Q-loop/lid; other site 877468011193 ABC transporter signature motif; other site 877468011194 Walker B; other site 877468011195 D-loop; other site 877468011196 H-loop/switch region; other site 877468011197 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 877468011198 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 877468011199 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 877468011200 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 877468011201 outer membrane receptor FepA; Provisional; Region: PRK13528 877468011202 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 877468011203 N-terminal plug; other site 877468011204 ligand-binding site [chemical binding]; other site 877468011205 secreted effector protein PipB2; Provisional; Region: PRK15196 877468011206 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 877468011207 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 877468011208 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 877468011209 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 877468011210 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 877468011211 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 877468011212 antimicrobial resistance protein Mig-14; Provisional; Region: PRK15312 877468011213 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 877468011214 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 877468011215 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 877468011216 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 877468011217 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 877468011218 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 877468011219 dimer interface [polypeptide binding]; other site 877468011220 phosphorylation site [posttranslational modification] 877468011221 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 877468011222 ATP binding site [chemical binding]; other site 877468011223 Mg2+ binding site [ion binding]; other site 877468011224 G-X-G motif; other site 877468011225 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 877468011226 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 877468011227 active site 877468011228 phosphorylation site [posttranslational modification] 877468011229 intermolecular recognition site; other site 877468011230 dimerization interface [polypeptide binding]; other site 877468011231 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 877468011232 DNA binding site [nucleotide binding] 877468011233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 877468011234 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 877468011235 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 877468011236 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 877468011237 substrate binding pocket [chemical binding]; other site 877468011238 active site 877468011239 iron coordination sites [ion binding]; other site 877468011240 Predicted dehydrogenase [General function prediction only]; Region: COG0579 877468011241 hydroxyglutarate oxidase; Provisional; Region: PRK11728 877468011242 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 877468011243 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 877468011244 tetramerization interface [polypeptide binding]; other site 877468011245 NAD(P) binding site [chemical binding]; other site 877468011246 catalytic residues [active] 877468011247 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 877468011248 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 877468011249 inhibitor-cofactor binding pocket; inhibition site 877468011250 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468011251 catalytic residue [active] 877468011252 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 877468011253 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 877468011254 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 877468011255 DNA-binding site [nucleotide binding]; DNA binding site 877468011256 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 877468011257 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 877468011258 bacterial OsmY and nodulation domain; Region: BON; smart00749 877468011259 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 877468011260 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 877468011261 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 877468011262 dimerization interface [polypeptide binding]; other site 877468011263 putative DNA binding site [nucleotide binding]; other site 877468011264 Transcriptional regulators [Transcription]; Region: MarR; COG1846 877468011265 putative Zn2+ binding site [ion binding]; other site 877468011266 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 877468011267 active site residue [active] 877468011268 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 877468011269 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 877468011270 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 877468011271 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 877468011272 hypothetical protein; Provisional; Region: PRK10556 877468011273 hypothetical protein; Provisional; Region: PRK10132 877468011274 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 877468011275 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 877468011276 DNA-binding site [nucleotide binding]; DNA binding site 877468011277 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 877468011278 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468011279 homodimer interface [polypeptide binding]; other site 877468011280 catalytic residue [active] 877468011281 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 877468011282 Uncharacterized conserved protein [Function unknown]; Region: COG2128 877468011283 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 877468011284 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 877468011285 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 877468011286 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 877468011287 Class I ribonucleotide reductase; Region: RNR_I; cd01679 877468011288 active site 877468011289 dimer interface [polypeptide binding]; other site 877468011290 catalytic residues [active] 877468011291 effector binding site; other site 877468011292 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 877468011293 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 877468011294 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 877468011295 dimer interface [polypeptide binding]; other site 877468011296 putative radical transfer pathway; other site 877468011297 diiron center [ion binding]; other site 877468011298 tyrosyl radical; other site 877468011299 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 877468011300 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 877468011301 Walker A/P-loop; other site 877468011302 ATP binding site [chemical binding]; other site 877468011303 Q-loop/lid; other site 877468011304 ABC transporter signature motif; other site 877468011305 Walker B; other site 877468011306 D-loop; other site 877468011307 H-loop/switch region; other site 877468011308 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 877468011309 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 877468011310 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 877468011311 dimer interface [polypeptide binding]; other site 877468011312 conserved gate region; other site 877468011313 putative PBP binding loops; other site 877468011314 ABC-ATPase subunit interface; other site 877468011315 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 877468011316 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 877468011317 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 877468011318 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468011319 transcriptional repressor MprA; Provisional; Region: PRK10870 877468011320 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 877468011321 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 877468011322 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 877468011323 HlyD family secretion protein; Region: HlyD_3; pfam13437 877468011324 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 877468011325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468011326 putative substrate translocation pore; other site 877468011327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468011328 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 877468011329 S-ribosylhomocysteinase; Provisional; Region: PRK02260 877468011330 glutamate--cysteine ligase; Provisional; Region: PRK02107 877468011331 Predicted membrane protein [Function unknown]; Region: COG1238 877468011332 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 877468011333 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 877468011334 motif II; other site 877468011335 carbon storage regulator; Provisional; Region: PRK01712 877468011336 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 877468011337 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 877468011338 motif 1; other site 877468011339 active site 877468011340 motif 2; other site 877468011341 motif 3; other site 877468011342 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 877468011343 DHHA1 domain; Region: DHHA1; pfam02272 877468011344 recombination regulator RecX; Reviewed; Region: recX; PRK00117 877468011345 recombinase A; Provisional; Region: recA; PRK09354 877468011346 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 877468011347 hexamer interface [polypeptide binding]; other site 877468011348 Walker A motif; other site 877468011349 ATP binding site [chemical binding]; other site 877468011350 Walker B motif; other site 877468011351 hypothetical protein; Validated; Region: PRK03661 877468011352 Transglycosylase SLT domain; Region: SLT_2; pfam13406 877468011353 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 877468011354 N-acetyl-D-glucosamine binding site [chemical binding]; other site 877468011355 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 877468011356 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 877468011357 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 877468011358 Nucleoside recognition; Region: Gate; pfam07670 877468011359 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 877468011360 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 877468011361 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 877468011362 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 877468011363 putative NAD(P) binding site [chemical binding]; other site 877468011364 active site 877468011365 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 877468011366 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 877468011367 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 877468011368 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 877468011369 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 877468011370 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 877468011371 putative active site [active] 877468011372 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 877468011373 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 877468011374 GAF domain; Region: GAF; pfam01590 877468011375 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 877468011376 Walker A motif; other site 877468011377 ATP binding site [chemical binding]; other site 877468011378 Walker B motif; other site 877468011379 arginine finger; other site 877468011380 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 877468011381 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 877468011382 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 877468011383 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 877468011384 iron binding site [ion binding]; other site 877468011385 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 877468011386 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 877468011387 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 877468011388 Acylphosphatase; Region: Acylphosphatase; pfam00708 877468011389 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 877468011390 HypF finger; Region: zf-HYPF; pfam07503 877468011391 HypF finger; Region: zf-HYPF; pfam07503 877468011392 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 877468011393 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 877468011394 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 877468011395 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 877468011396 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 877468011397 nickel binding site [ion binding]; other site 877468011398 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 877468011399 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 877468011400 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 877468011401 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 877468011402 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 877468011403 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 877468011404 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 877468011405 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 877468011406 NADH dehydrogenase; Region: NADHdh; cl00469 877468011407 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 877468011408 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 877468011409 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 877468011410 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 877468011411 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 877468011412 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 877468011413 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 877468011414 hydrogenase assembly chaperone; Provisional; Region: PRK10409 877468011415 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 877468011416 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 877468011417 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 877468011418 dimerization interface [polypeptide binding]; other site 877468011419 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 877468011420 ATP binding site [chemical binding]; other site 877468011421 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 877468011422 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 877468011423 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 877468011424 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 877468011425 Walker A motif; other site 877468011426 ATP binding site [chemical binding]; other site 877468011427 Walker B motif; other site 877468011428 arginine finger; other site 877468011429 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 877468011430 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 877468011431 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 877468011432 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 877468011433 metal binding site [ion binding]; metal-binding site 877468011434 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 877468011435 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 877468011436 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 877468011437 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 877468011438 ABC-ATPase subunit interface; other site 877468011439 dimer interface [polypeptide binding]; other site 877468011440 putative PBP binding regions; other site 877468011441 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 877468011442 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 877468011443 ABC-ATPase subunit interface; other site 877468011444 dimer interface [polypeptide binding]; other site 877468011445 putative PBP binding regions; other site 877468011446 effector protein YopJ; Provisional; Region: PRK15371 877468011447 transcriptional activator SprB; Provisional; Region: PRK15320 877468011448 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 877468011449 transcriptional regulator SirC; Provisional; Region: PRK15044 877468011450 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 877468011451 putative type III secretion system effector protein OrgC; Provisional; Region: PRK15321 877468011452 invasion protein OrgB; Provisional; Region: PRK15322 877468011453 type III secretion apparatus protein OrgA/MxiK; Region: OrgA_MxiK; TIGR02555 877468011454 invasion protein OrgA; Provisional; Region: PRK15323 877468011455 type III secretion system lipoprotein PrgK; Provisional; Region: PRK15324 877468011456 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 877468011457 type III secretion system needle complex protein PrgI; Provisional; Region: PRK15326 877468011458 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327 877468011459 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 877468011460 transcriptional regulator HilD; Provisional; Region: PRK15185 877468011461 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 877468011462 invasion protein regulator; Provisional; Region: PRK12370 877468011463 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 877468011464 DNA binding site [nucleotide binding] 877468011465 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 877468011466 binding surface 877468011467 TPR motif; other site 877468011468 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 877468011469 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 877468011470 N-acetyl-D-glucosamine binding site [chemical binding]; other site 877468011471 catalytic residue [active] 877468011472 pathogenicity island 1 effector protein StpP; Provisional; Region: PRK15375 877468011473 SicP binding; Region: SicP-binding; pfam09119 877468011474 GTPase-activating protein (GAP) domain found in bacterial cytotoxins, ExoS, SptP, and YopE. Part of protein secretion system; stimulates Rac1- dependent cytoskeletal changes that promote bacterial internalization; Region: ToxGAP; cd00219 877468011475 switch II binding region; other site 877468011476 Rac1 P-loop interaction site [polypeptide binding]; other site 877468011477 GTP binding residues [chemical binding]; other site 877468011478 switch I binding region; other site 877468011479 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047 877468011480 active site 877468011481 chaperone protein SicP; Provisional; Region: PRK15329 877468011482 putative acyl carrier protein IacP; Validated; Region: PRK08172 877468011483 pathogenicity island 1 effector protein SipA; Provisional; Region: PRK15376 877468011484 cell invasion protein SipD; Provisional; Region: PRK15330 877468011485 pathogenicity island 1 effector protein SipC; Provisional; Region: PRK15373 877468011486 pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374 877468011487 chaperone protein SicA; Provisional; Region: PRK15331 877468011488 Tetratricopeptide repeat; Region: TPR_3; pfam07720 877468011489 Tetratricopeptide repeat; Region: TPR_3; pfam07720 877468011490 type III secretion system protein SpaS; Validated; Region: PRK08156 877468011491 type III secretion system protein SpaR; Provisional; Region: PRK15332 877468011492 type III secretion system protein SpaQ; Provisional; Region: PRK15333 877468011493 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 877468011494 type III secretion system protein SpaO; Validated; Region: PRK08158 877468011495 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 877468011496 antigen presentation protein SpaN; Provisional; Region: PRK15334 877468011497 Surface presentation of antigens protein; Region: SPAN; pfam02510 877468011498 Salmonella surface presentation of antigen gene type M protein; Region: SPAM; cl03442 877468011499 ATP synthase SpaL; Validated; Region: PRK08149 877468011500 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 877468011501 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 877468011502 Walker A motif; other site 877468011503 ATP binding site [chemical binding]; other site 877468011504 Walker B motif; other site 877468011505 Invasion protein B family; Region: Invas_SpaK; cl04129 877468011506 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 877468011507 type III secretion system protein InvA; Provisional; Region: PRK15337 877468011508 type III secretion system regulator InvE; Provisional; Region: PRK15338 877468011509 type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568 877468011510 type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339 877468011511 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 877468011512 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 877468011513 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 877468011514 transcriptional regulator InvF; Provisional; Region: PRK15340 877468011515 InvH outer membrane lipoprotein; Region: InvH; pfam04741 877468011516 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 877468011517 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 877468011518 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 877468011519 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 877468011520 active site 877468011521 metal binding site [ion binding]; metal-binding site 877468011522 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 877468011523 MutS domain I; Region: MutS_I; pfam01624 877468011524 MutS domain II; Region: MutS_II; pfam05188 877468011525 MutS domain III; Region: MutS_III; pfam05192 877468011526 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 877468011527 Walker A/P-loop; other site 877468011528 ATP binding site [chemical binding]; other site 877468011529 Q-loop/lid; other site 877468011530 ABC transporter signature motif; other site 877468011531 Walker B; other site 877468011532 D-loop; other site 877468011533 H-loop/switch region; other site 877468011534 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 877468011535 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468011536 Major Facilitator Superfamily; Region: MFS_1; pfam07690 877468011537 putative substrate translocation pore; other site 877468011538 Transcriptional regulator [Transcription]; Region: LysR; COG0583 877468011539 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468011540 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 877468011541 putative effector binding pocket; other site 877468011542 dimerization interface [polypeptide binding]; other site 877468011543 GntP family permease; Region: GntP_permease; pfam02447 877468011544 fructuronate transporter; Provisional; Region: PRK10034; cl15264 877468011545 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 877468011546 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 877468011547 putative NAD(P) binding site [chemical binding]; other site 877468011548 active site 877468011549 putative substrate binding site [chemical binding]; other site 877468011550 hypothetical protein; Provisional; Region: PRK09989 877468011551 putative aldolase; Validated; Region: PRK08130 877468011552 intersubunit interface [polypeptide binding]; other site 877468011553 active site 877468011554 Zn2+ binding site [ion binding]; other site 877468011555 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 877468011556 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 877468011557 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 877468011558 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 877468011559 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 877468011560 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 877468011561 MarR family; Region: MarR_2; cl17246 877468011562 Transcriptional regulators [Transcription]; Region: MarR; COG1846 877468011563 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 877468011564 Flavoprotein; Region: Flavoprotein; pfam02441 877468011565 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 877468011566 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 877468011567 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 877468011568 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 877468011569 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 877468011570 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 877468011571 DNA binding residues [nucleotide binding] 877468011572 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 877468011573 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 877468011574 Peptidase family M23; Region: Peptidase_M23; pfam01551 877468011575 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 877468011576 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 877468011577 S-adenosylmethionine binding site [chemical binding]; other site 877468011578 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 877468011579 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 877468011580 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 877468011581 Permutation of conserved domain; other site 877468011582 active site 877468011583 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 877468011584 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 877468011585 homotrimer interaction site [polypeptide binding]; other site 877468011586 zinc binding site [ion binding]; other site 877468011587 CDP-binding sites; other site 877468011588 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 877468011589 substrate binding site; other site 877468011590 dimer interface; other site 877468011591 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 877468011592 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 877468011593 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 877468011594 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 877468011595 ligand-binding site [chemical binding]; other site 877468011596 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 877468011597 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 877468011598 CysD dimerization site [polypeptide binding]; other site 877468011599 G1 box; other site 877468011600 putative GEF interaction site [polypeptide binding]; other site 877468011601 GTP/Mg2+ binding site [chemical binding]; other site 877468011602 Switch I region; other site 877468011603 G2 box; other site 877468011604 G3 box; other site 877468011605 Switch II region; other site 877468011606 G4 box; other site 877468011607 G5 box; other site 877468011608 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 877468011609 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 877468011610 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 877468011611 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 877468011612 Active Sites [active] 877468011613 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 877468011614 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 877468011615 metal binding site [ion binding]; metal-binding site 877468011616 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 877468011617 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 877468011618 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09664 877468011619 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 877468011620 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 877468011621 CT1975-like protein; Region: Cas_CT1975; pfam09344 877468011622 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09670 877468011623 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 877468011624 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 877468011625 DEAD-like helicases superfamily; Region: DEXDc; smart00487 877468011626 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 877468011627 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 877468011628 pathogenicity island 1 effector protein SopD; Provisional; Region: PRK15379 877468011629 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 877468011630 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 877468011631 Active Sites [active] 877468011632 sulfite reductase subunit beta; Provisional; Region: PRK13504 877468011633 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 877468011634 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 877468011635 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 877468011636 Flavodoxin; Region: Flavodoxin_1; pfam00258 877468011637 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 877468011638 FAD binding pocket [chemical binding]; other site 877468011639 FAD binding motif [chemical binding]; other site 877468011640 catalytic residues [active] 877468011641 NAD binding pocket [chemical binding]; other site 877468011642 phosphate binding motif [ion binding]; other site 877468011643 beta-alpha-beta structure motif; other site 877468011644 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 877468011645 active site 877468011646 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 877468011647 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 877468011648 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 877468011649 enolase; Provisional; Region: eno; PRK00077 877468011650 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 877468011651 dimer interface [polypeptide binding]; other site 877468011652 metal binding site [ion binding]; metal-binding site 877468011653 substrate binding pocket [chemical binding]; other site 877468011654 CTP synthetase; Validated; Region: pyrG; PRK05380 877468011655 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 877468011656 Catalytic site [active] 877468011657 active site 877468011658 UTP binding site [chemical binding]; other site 877468011659 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 877468011660 active site 877468011661 putative oxyanion hole; other site 877468011662 catalytic triad [active] 877468011663 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 877468011664 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 877468011665 homodimer interface [polypeptide binding]; other site 877468011666 metal binding site [ion binding]; metal-binding site 877468011667 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 877468011668 homodimer interface [polypeptide binding]; other site 877468011669 active site 877468011670 putative chemical substrate binding site [chemical binding]; other site 877468011671 metal binding site [ion binding]; metal-binding site 877468011672 fimbrial protein SteA; Provisional; Region: PRK15261 877468011673 putative fimbrial outer membrane usher protein SteB; Provisional; Region: PRK15273 877468011674 PapC N-terminal domain; Region: PapC_N; pfam13954 877468011675 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 877468011676 PapC C-terminal domain; Region: PapC_C; pfam13953 877468011677 putative periplasmic fimbrial chaperone protein SteC; Provisional; Region: PRK15274 877468011678 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 877468011679 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 877468011680 putative fimbrial protein SteD; Provisional; Region: PRK15275 877468011681 putative fimbrial subunit SteE; Provisional; Region: PRK15276 877468011682 fimbrial protein SteF; Provisional; Region: PRK15260 877468011683 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 877468011684 HD domain; Region: HD_4; pfam13328 877468011685 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 877468011686 synthetase active site [active] 877468011687 NTP binding site [chemical binding]; other site 877468011688 metal binding site [ion binding]; metal-binding site 877468011689 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 877468011690 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 877468011691 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 877468011692 TRAM domain; Region: TRAM; pfam01938 877468011693 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 877468011694 S-adenosylmethionine binding site [chemical binding]; other site 877468011695 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 877468011696 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 877468011697 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 877468011698 dimerization interface [polypeptide binding]; other site 877468011699 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 877468011700 dimer interface [polypeptide binding]; other site 877468011701 phosphorylation site [posttranslational modification] 877468011702 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 877468011703 ATP binding site [chemical binding]; other site 877468011704 Mg2+ binding site [ion binding]; other site 877468011705 G-X-G motif; other site 877468011706 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 877468011707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 877468011708 active site 877468011709 phosphorylation site [posttranslational modification] 877468011710 intermolecular recognition site; other site 877468011711 dimerization interface [polypeptide binding]; other site 877468011712 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 877468011713 putative binding surface; other site 877468011714 active site 877468011715 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 877468011716 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 877468011717 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 877468011718 active site 877468011719 tetramer interface [polypeptide binding]; other site 877468011720 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 877468011721 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 877468011722 active site 877468011723 tetramer interface [polypeptide binding]; other site 877468011724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468011725 D-galactonate transporter; Region: 2A0114; TIGR00893 877468011726 putative substrate translocation pore; other site 877468011727 flavodoxin; Provisional; Region: PRK08105 877468011728 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 877468011729 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 877468011730 probable active site [active] 877468011731 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 877468011732 SecY interacting protein Syd; Provisional; Region: PRK04968 877468011733 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 877468011734 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 877468011735 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 877468011736 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 877468011737 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 877468011738 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 877468011739 serine transporter; Region: stp; TIGR00814 877468011740 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 877468011741 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 877468011742 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 877468011743 flap endonuclease-like protein; Provisional; Region: PRK09482 877468011744 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 877468011745 active site 877468011746 metal binding site 1 [ion binding]; metal-binding site 877468011747 putative 5' ssDNA interaction site; other site 877468011748 metal binding site 3; metal-binding site 877468011749 metal binding site 2 [ion binding]; metal-binding site 877468011750 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 877468011751 putative DNA binding site [nucleotide binding]; other site 877468011752 putative metal binding site [ion binding]; other site 877468011753 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 877468011754 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 877468011755 dimer interface [polypeptide binding]; other site 877468011756 active site 877468011757 metal binding site [ion binding]; metal-binding site 877468011758 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 877468011759 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 877468011760 intersubunit interface [polypeptide binding]; other site 877468011761 active site 877468011762 Zn2+ binding site [ion binding]; other site 877468011763 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 877468011764 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468011765 putative substrate translocation pore; other site 877468011766 L-fucose isomerase; Provisional; Region: fucI; PRK10991 877468011767 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 877468011768 hexamer (dimer of trimers) interface [polypeptide binding]; other site 877468011769 trimer interface [polypeptide binding]; other site 877468011770 substrate binding site [chemical binding]; other site 877468011771 Mn binding site [ion binding]; other site 877468011772 L-fuculokinase; Provisional; Region: PRK10331 877468011773 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 877468011774 nucleotide binding site [chemical binding]; other site 877468011775 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 877468011776 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 877468011777 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 877468011778 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 877468011779 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 877468011780 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 877468011781 hypothetical protein; Provisional; Region: PRK10873 877468011782 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 877468011783 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468011784 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 877468011785 dimerization interface [polypeptide binding]; other site 877468011786 substrate binding pocket [chemical binding]; other site 877468011787 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 877468011788 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 877468011789 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 877468011790 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 877468011791 catalytic residue [active] 877468011792 CsdA-binding activator; Provisional; Region: PRK15019 877468011793 Predicted permeases [General function prediction only]; Region: RarD; COG2962 877468011794 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 877468011795 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 877468011796 putative ATP binding site [chemical binding]; other site 877468011797 putative substrate interface [chemical binding]; other site 877468011798 murein transglycosylase A; Provisional; Region: mltA; PRK11162 877468011799 murein hydrolase B; Provisional; Region: PRK10760; cl17906 877468011800 MltA specific insert domain; Region: MltA; pfam03562 877468011801 3D domain; Region: 3D; pfam06725 877468011802 AMIN domain; Region: AMIN; pfam11741 877468011803 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 877468011804 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 877468011805 active site 877468011806 metal binding site [ion binding]; metal-binding site 877468011807 N-acetylglutamate synthase; Validated; Region: PRK05279 877468011808 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 877468011809 putative feedback inhibition sensing region; other site 877468011810 putative nucleotide binding site [chemical binding]; other site 877468011811 putative substrate binding site [chemical binding]; other site 877468011812 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 877468011813 Coenzyme A binding pocket [chemical binding]; other site 877468011814 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 877468011815 AAA domain; Region: AAA_30; pfam13604 877468011816 Family description; Region: UvrD_C_2; pfam13538 877468011817 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 877468011818 protease3; Provisional; Region: PRK15101 877468011819 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 877468011820 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 877468011821 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 877468011822 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 877468011823 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 877468011824 hypothetical protein; Provisional; Region: PRK10332 877468011825 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 877468011826 hypothetical protein; Provisional; Region: PRK11521 877468011827 hypothetical protein; Provisional; Region: PRK10557 877468011828 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 877468011829 hypothetical protein; Provisional; Region: PRK10506 877468011830 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 877468011831 thymidylate synthase; Reviewed; Region: thyA; PRK01827 877468011832 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 877468011833 dimerization interface [polypeptide binding]; other site 877468011834 active site 877468011835 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 877468011836 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 877468011837 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 877468011838 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 877468011839 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 877468011840 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 877468011841 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 877468011842 putative active site [active] 877468011843 Ap4A binding site [chemical binding]; other site 877468011844 nudix motif; other site 877468011845 putative metal binding site [ion binding]; other site 877468011846 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 877468011847 putative DNA-binding cleft [nucleotide binding]; other site 877468011848 putative DNA clevage site; other site 877468011849 molecular lever; other site 877468011850 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 877468011851 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 877468011852 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 877468011853 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 877468011854 active site 877468011855 catalytic tetrad [active] 877468011856 lysophospholipid transporter LplT; Provisional; Region: PRK11195 877468011857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468011858 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 877468011859 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 877468011860 putative acyl-acceptor binding pocket; other site 877468011861 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 877468011862 acyl-activating enzyme (AAE) consensus motif; other site 877468011863 putative AMP binding site [chemical binding]; other site 877468011864 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 877468011865 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 877468011866 DNA binding site [nucleotide binding] 877468011867 domain linker motif; other site 877468011868 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 877468011869 dimerization interface (closed form) [polypeptide binding]; other site 877468011870 ligand binding site [chemical binding]; other site 877468011871 Transcriptional regulators [Transcription]; Region: PurR; COG1609 877468011872 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 877468011873 DNA binding site [nucleotide binding] 877468011874 domain linker motif; other site 877468011875 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 877468011876 dimerization interface (closed form) [polypeptide binding]; other site 877468011877 ligand binding site [chemical binding]; other site 877468011878 diaminopimelate decarboxylase; Provisional; Region: PRK11165 877468011879 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 877468011880 active site 877468011881 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 877468011882 substrate binding site [chemical binding]; other site 877468011883 catalytic residues [active] 877468011884 dimer interface [polypeptide binding]; other site 877468011885 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 877468011886 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468011887 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 877468011888 dimerization interface [polypeptide binding]; other site 877468011889 putative racemase; Provisional; Region: PRK10200 877468011890 aspartate racemase; Region: asp_race; TIGR00035 877468011891 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 877468011892 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468011893 putative substrate translocation pore; other site 877468011894 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468011895 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 877468011896 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 877468011897 NADP binding site [chemical binding]; other site 877468011898 homodimer interface [polypeptide binding]; other site 877468011899 active site 877468011900 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 877468011901 putative acyltransferase; Provisional; Region: PRK05790 877468011902 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 877468011903 dimer interface [polypeptide binding]; other site 877468011904 active site 877468011905 Transcriptional regulator [Transcription]; Region: LysR; COG0583 877468011906 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468011907 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 877468011908 dimerization interface [polypeptide binding]; other site 877468011909 Predicted membrane protein [Function unknown]; Region: COG4125 877468011910 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 877468011911 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 877468011912 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 877468011913 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 877468011914 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 877468011915 putative metal binding site [ion binding]; other site 877468011916 putative homodimer interface [polypeptide binding]; other site 877468011917 putative homotetramer interface [polypeptide binding]; other site 877468011918 putative homodimer-homodimer interface [polypeptide binding]; other site 877468011919 putative allosteric switch controlling residues; other site 877468011920 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 877468011921 transcriptional activator SprB; Provisional; Region: PRK15320 877468011922 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14600 877468011923 Protein of unknown function (DUF1401); Region: DUF1401; pfam07180 877468011924 Fimbrial protein; Region: Fimbrial; pfam00419 877468011925 fimbrial chaperone protein StdC; Provisional; Region: PRK15254 877468011926 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 877468011927 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 877468011928 fimbrial outer membrane usher protein StdB; Provisional; Region: PRK15255 877468011929 PapC N-terminal domain; Region: PapC_N; pfam13954 877468011930 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 877468011931 PapC C-terminal domain; Region: PapC_C; pfam13953 877468011932 fimbrial protein StdA; Provisional; Region: PRK15210 877468011933 hypothetical protein; Provisional; Region: PRK10316 877468011934 YfdX protein; Region: YfdX; pfam10938 877468011935 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 877468011936 oligomeric interface; other site 877468011937 putative active site [active] 877468011938 homodimer interface [polypeptide binding]; other site 877468011939 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 877468011940 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 877468011941 Peptidase family M23; Region: Peptidase_M23; pfam01551 877468011942 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 877468011943 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 877468011944 active site 877468011945 metal binding site [ion binding]; metal-binding site 877468011946 nudix motif; other site 877468011947 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 877468011948 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 877468011949 dimer interface [polypeptide binding]; other site 877468011950 putative anticodon binding site; other site 877468011951 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 877468011952 motif 1; other site 877468011953 active site 877468011954 motif 2; other site 877468011955 motif 3; other site 877468011956 This domain is found in peptide chain release factors; Region: PCRF; smart00937 877468011957 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 877468011958 RF-1 domain; Region: RF-1; pfam00472 877468011959 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 877468011960 DHH family; Region: DHH; pfam01368 877468011961 DHHA1 domain; Region: DHHA1; pfam02272 877468011962 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 877468011963 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 877468011964 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 877468011965 dimerization domain [polypeptide binding]; other site 877468011966 dimer interface [polypeptide binding]; other site 877468011967 catalytic residues [active] 877468011968 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 877468011969 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 877468011970 active site 877468011971 Int/Topo IB signature motif; other site 877468011972 flavodoxin FldB; Provisional; Region: PRK12359 877468011973 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 877468011974 hypothetical protein; Provisional; Region: PRK10878 877468011975 putative global regulator; Reviewed; Region: PRK09559 877468011976 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 877468011977 hemolysin; Provisional; Region: PRK15087 877468011978 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 877468011979 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 877468011980 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 877468011981 beta-galactosidase; Region: BGL; TIGR03356 877468011982 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 877468011983 glycine dehydrogenase; Provisional; Region: PRK05367 877468011984 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 877468011985 tetramer interface [polypeptide binding]; other site 877468011986 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468011987 catalytic residue [active] 877468011988 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 877468011989 tetramer interface [polypeptide binding]; other site 877468011990 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468011991 catalytic residue [active] 877468011992 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 877468011993 lipoyl attachment site [posttranslational modification]; other site 877468011994 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 877468011995 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 877468011996 oxidoreductase; Provisional; Region: PRK08013 877468011997 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 877468011998 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 877468011999 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 877468012000 proline aminopeptidase P II; Provisional; Region: PRK10879 877468012001 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 877468012002 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 877468012003 active site 877468012004 hypothetical protein; Reviewed; Region: PRK01736 877468012005 Cell division protein ZapA; Region: ZapA; cl01146 877468012006 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 877468012007 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 877468012008 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 877468012009 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 877468012010 ligand binding site [chemical binding]; other site 877468012011 NAD binding site [chemical binding]; other site 877468012012 tetramer interface [polypeptide binding]; other site 877468012013 catalytic site [active] 877468012014 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 877468012015 L-serine binding site [chemical binding]; other site 877468012016 ACT domain interface; other site 877468012017 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 877468012018 tetramer (dimer of dimers) interface [polypeptide binding]; other site 877468012019 active site 877468012020 dimer interface [polypeptide binding]; other site 877468012021 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 877468012022 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468012023 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 877468012024 putative dimerization interface [polypeptide binding]; other site 877468012025 Uncharacterized conserved protein [Function unknown]; Region: COG2968 877468012026 oxidative stress defense protein; Provisional; Region: PRK11087 877468012027 arginine exporter protein; Provisional; Region: PRK09304 877468012028 mechanosensitive channel MscS; Provisional; Region: PRK10334 877468012029 Mechanosensitive ion channel; Region: MS_channel; pfam00924 877468012030 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 877468012031 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 877468012032 active site 877468012033 intersubunit interface [polypeptide binding]; other site 877468012034 zinc binding site [ion binding]; other site 877468012035 Na+ binding site [ion binding]; other site 877468012036 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 877468012037 Phosphoglycerate kinase; Region: PGK; pfam00162 877468012038 substrate binding site [chemical binding]; other site 877468012039 hinge regions; other site 877468012040 ADP binding site [chemical binding]; other site 877468012041 catalytic site [active] 877468012042 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 877468012043 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 877468012044 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 877468012045 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 877468012046 trimer interface [polypeptide binding]; other site 877468012047 putative Zn binding site [ion binding]; other site 877468012048 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 877468012049 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 877468012050 Walker A/P-loop; other site 877468012051 ATP binding site [chemical binding]; other site 877468012052 ABC transporter; Region: ABC_tran; pfam00005 877468012053 Q-loop/lid; other site 877468012054 ABC transporter signature motif; other site 877468012055 Walker B; other site 877468012056 D-loop; other site 877468012057 H-loop/switch region; other site 877468012058 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 877468012059 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 877468012060 Walker A/P-loop; other site 877468012061 ATP binding site [chemical binding]; other site 877468012062 Q-loop/lid; other site 877468012063 ABC transporter signature motif; other site 877468012064 Walker B; other site 877468012065 D-loop; other site 877468012066 H-loop/switch region; other site 877468012067 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 877468012068 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 877468012069 active site 877468012070 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 877468012071 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 877468012072 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 877468012073 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 877468012074 putative active site [active] 877468012075 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 877468012076 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 877468012077 putative NAD(P) binding site [chemical binding]; other site 877468012078 catalytic Zn binding site [ion binding]; other site 877468012079 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 877468012080 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 877468012081 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 877468012082 active site 877468012083 P-loop; other site 877468012084 phosphorylation site [posttranslational modification] 877468012085 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 877468012086 active site 877468012087 phosphorylation site [posttranslational modification] 877468012088 transketolase; Reviewed; Region: PRK12753 877468012089 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 877468012090 TPP-binding site [chemical binding]; other site 877468012091 dimer interface [polypeptide binding]; other site 877468012092 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 877468012093 PYR/PP interface [polypeptide binding]; other site 877468012094 dimer interface [polypeptide binding]; other site 877468012095 TPP binding site [chemical binding]; other site 877468012096 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 877468012097 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 877468012098 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 877468012099 agmatinase; Region: agmatinase; TIGR01230 877468012100 oligomer interface [polypeptide binding]; other site 877468012101 putative active site [active] 877468012102 Mn binding site [ion binding]; other site 877468012103 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 877468012104 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 877468012105 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 877468012106 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 877468012107 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 877468012108 putative NAD(P) binding site [chemical binding]; other site 877468012109 catalytic Zn binding site [ion binding]; other site 877468012110 structural Zn binding site [ion binding]; other site 877468012111 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 877468012112 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 877468012113 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 877468012114 Transcriptional regulators [Transcription]; Region: FadR; COG2186 877468012115 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 877468012116 DNA-binding site [nucleotide binding]; DNA binding site 877468012117 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 877468012118 DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237 877468012119 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 877468012120 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 877468012121 dimer interface [polypeptide binding]; other site 877468012122 active site 877468012123 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 877468012124 catalytic residues [active] 877468012125 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 877468012126 Virulence promoting factor; Region: YqgB; pfam11036 877468012127 S-adenosylmethionine synthetase; Validated; Region: PRK05250 877468012128 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 877468012129 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 877468012130 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 877468012131 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 877468012132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468012133 putative substrate translocation pore; other site 877468012134 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468012135 hypothetical protein; Provisional; Region: PRK04860 877468012136 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 877468012137 DNA-specific endonuclease I; Provisional; Region: PRK15137 877468012138 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 877468012139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 877468012140 RNA methyltransferase, RsmE family; Region: TIGR00046 877468012141 glutathione synthetase; Provisional; Region: PRK05246 877468012142 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 877468012143 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 877468012144 hypothetical protein; Validated; Region: PRK00228 877468012145 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 877468012146 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 877468012147 Transcriptional regulator [Transcription]; Region: IclR; COG1414 877468012148 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 877468012149 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 877468012150 Walker A motif; other site 877468012151 ATP binding site [chemical binding]; other site 877468012152 Walker B motif; other site 877468012153 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 877468012154 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 877468012155 catalytic residue [active] 877468012156 YGGT family; Region: YGGT; pfam02325 877468012157 YGGT family; Region: YGGT; pfam02325 877468012158 hypothetical protein; Validated; Region: PRK05090 877468012159 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 877468012160 active site 877468012161 dimerization interface [polypeptide binding]; other site 877468012162 HemN family oxidoreductase; Provisional; Region: PRK05660 877468012163 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 877468012164 FeS/SAM binding site; other site 877468012165 HemN C-terminal domain; Region: HemN_C; pfam06969 877468012166 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 877468012167 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 877468012168 homodimer interface [polypeptide binding]; other site 877468012169 active site 877468012170 hypothetical protein; Provisional; Region: PRK10626 877468012171 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 877468012172 hypothetical protein; Provisional; Region: PRK11702 877468012173 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 877468012174 adenine DNA glycosylase; Provisional; Region: PRK10880 877468012175 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 877468012176 minor groove reading motif; other site 877468012177 helix-hairpin-helix signature motif; other site 877468012178 substrate binding pocket [chemical binding]; other site 877468012179 active site 877468012180 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 877468012181 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 877468012182 DNA binding and oxoG recognition site [nucleotide binding] 877468012183 oxidative damage protection protein; Provisional; Region: PRK05408 877468012184 murein transglycosylase C; Provisional; Region: mltC; PRK11671 877468012185 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 877468012186 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 877468012187 N-acetyl-D-glucosamine binding site [chemical binding]; other site 877468012188 catalytic residue [active] 877468012189 nucleoside transporter; Region: 2A0110; TIGR00889 877468012190 ornithine decarboxylase; Provisional; Region: PRK13578 877468012191 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 877468012192 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 877468012193 homodimer interface [polypeptide binding]; other site 877468012194 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468012195 catalytic residue [active] 877468012196 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 877468012197 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 877468012198 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 877468012199 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 877468012200 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 877468012201 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 877468012202 putative active site [active] 877468012203 putative catalytic site [active] 877468012204 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 877468012205 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 877468012206 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468012207 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 877468012208 putative dimerization interface [polypeptide binding]; other site 877468012209 putative substrate binding pocket [chemical binding]; other site 877468012210 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 877468012211 Sulfatase; Region: Sulfatase; pfam00884 877468012212 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 877468012213 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 877468012214 FeS/SAM binding site; other site 877468012215 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 877468012216 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 877468012217 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 877468012218 DNA binding residues [nucleotide binding] 877468012219 dimerization interface [polypeptide binding]; other site 877468012220 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 877468012221 Amino acid permease; Region: AA_permease_2; pfam13520 877468012222 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 877468012223 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 877468012224 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 877468012225 Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113 877468012226 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 877468012227 NAD(P) binding site [chemical binding]; other site 877468012228 catalytic residues [active] 877468012229 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 877468012230 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 877468012231 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 877468012232 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 877468012233 tetramer interface [polypeptide binding]; other site 877468012234 active site 877468012235 Predicted amidohydrolase [General function prediction only]; Region: COG0388 877468012236 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 877468012237 putative active site [active] 877468012238 catalytic triad [active] 877468012239 putative dimer interface [polypeptide binding]; other site 877468012240 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468012241 D-galactonate transporter; Region: 2A0114; TIGR00893 877468012242 putative substrate translocation pore; other site 877468012243 mannonate dehydratase; Provisional; Region: PRK03906 877468012244 mannonate dehydratase; Region: uxuA; TIGR00695 877468012245 D-mannonate oxidoreductase; Provisional; Region: PRK15037 877468012246 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 877468012247 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 877468012248 Glucuronate isomerase; Region: UxaC; pfam02614 877468012249 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 877468012250 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 877468012251 dimer interface [polypeptide binding]; other site 877468012252 putative CheW interface [polypeptide binding]; other site 877468012253 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 877468012254 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 877468012255 CHAP domain; Region: CHAP; pfam05257 877468012256 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 877468012257 putative S-transferase; Provisional; Region: PRK11752 877468012258 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 877468012259 C-terminal domain interface [polypeptide binding]; other site 877468012260 GSH binding site (G-site) [chemical binding]; other site 877468012261 dimer interface [polypeptide binding]; other site 877468012262 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 877468012263 dimer interface [polypeptide binding]; other site 877468012264 N-terminal domain interface [polypeptide binding]; other site 877468012265 active site 877468012266 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 877468012267 molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537 877468012268 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 877468012269 putative ligand binding residues [chemical binding]; other site 877468012270 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 877468012271 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 877468012272 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 877468012273 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 877468012274 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 877468012275 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 877468012276 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 877468012277 putative substrate-binding site; other site 877468012278 nickel binding site [ion binding]; other site 877468012279 hydrogenase 2 large subunit; Provisional; Region: PRK10467 877468012280 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 877468012281 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 877468012282 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 877468012283 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 877468012284 4Fe-4S binding domain; Region: Fer4_6; pfam12837 877468012285 hydrogenase 2 small subunit; Provisional; Region: PRK10468 877468012286 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 877468012287 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 877468012288 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 877468012289 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 877468012290 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 877468012291 dimerization interface [polypeptide binding]; other site 877468012292 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 877468012293 dimer interface [polypeptide binding]; other site 877468012294 putative CheW interface [polypeptide binding]; other site 877468012295 hypothetical protein; Provisional; Region: PRK05208 877468012296 oxidoreductase; Provisional; Region: PRK07985 877468012297 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 877468012298 NAD binding site [chemical binding]; other site 877468012299 metal binding site [ion binding]; metal-binding site 877468012300 active site 877468012301 biopolymer transport protein ExbD; Provisional; Region: PRK11267 877468012302 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 877468012303 biopolymer transport protein ExbB; Provisional; Region: PRK10414 877468012304 cystathionine beta-lyase; Provisional; Region: PRK08114 877468012305 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 877468012306 homodimer interface [polypeptide binding]; other site 877468012307 substrate-cofactor binding pocket; other site 877468012308 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468012309 catalytic residue [active] 877468012310 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 877468012311 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 877468012312 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 877468012313 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 877468012314 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 877468012315 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 877468012316 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 877468012317 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 877468012318 dimer interface [polypeptide binding]; other site 877468012319 active site 877468012320 metal binding site [ion binding]; metal-binding site 877468012321 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 877468012322 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 877468012323 active site 877468012324 catalytic tetrad [active] 877468012325 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 877468012326 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 877468012327 transmembrane helices; other site 877468012328 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 877468012329 nucleotide binding site/active site [active] 877468012330 catalytic residue [active] 877468012331 hypothetical protein; Provisional; Region: PRK01254 877468012332 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 877468012333 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 877468012334 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 877468012335 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 877468012336 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 877468012337 DctM-like transporters; Region: DctM; pfam06808 877468012338 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 877468012339 FtsI repressor; Provisional; Region: PRK10883 877468012340 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 877468012341 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 877468012342 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 877468012343 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 877468012344 putative acyl-acceptor binding pocket; other site 877468012345 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 877468012346 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 877468012347 CAP-like domain; other site 877468012348 active site 877468012349 primary dimer interface [polypeptide binding]; other site 877468012350 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 877468012351 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 877468012352 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 877468012353 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 877468012354 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 877468012355 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 877468012356 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 877468012357 active site 877468012358 phosphorylation site [posttranslational modification] 877468012359 intermolecular recognition site; other site 877468012360 dimerization interface [polypeptide binding]; other site 877468012361 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 877468012362 DNA binding site [nucleotide binding] 877468012363 sensor protein QseC; Provisional; Region: PRK10337 877468012364 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 877468012365 dimer interface [polypeptide binding]; other site 877468012366 phosphorylation site [posttranslational modification] 877468012367 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 877468012368 ATP binding site [chemical binding]; other site 877468012369 Mg2+ binding site [ion binding]; other site 877468012370 G-X-G motif; other site 877468012371 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 877468012372 Uncharacterized conserved protein [Function unknown]; Region: COG1359 877468012373 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 877468012374 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 877468012375 ATP binding site [chemical binding]; other site 877468012376 Mg2+ binding site [ion binding]; other site 877468012377 G-X-G motif; other site 877468012378 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 877468012379 anchoring element; other site 877468012380 dimer interface [polypeptide binding]; other site 877468012381 ATP binding site [chemical binding]; other site 877468012382 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 877468012383 active site 877468012384 metal binding site [ion binding]; metal-binding site 877468012385 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 877468012386 esterase YqiA; Provisional; Region: PRK11071 877468012387 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 877468012388 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 877468012389 active site 877468012390 metal binding site [ion binding]; metal-binding site 877468012391 hexamer interface [polypeptide binding]; other site 877468012392 putative dehydrogenase; Provisional; Region: PRK11039 877468012393 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 877468012394 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 877468012395 dimer interface [polypeptide binding]; other site 877468012396 ADP-ribose binding site [chemical binding]; other site 877468012397 active site 877468012398 nudix motif; other site 877468012399 metal binding site [ion binding]; metal-binding site 877468012400 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 877468012401 hypothetical protein; Provisional; Region: PRK11653 877468012402 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 877468012403 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 877468012404 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 877468012405 putative active site [active] 877468012406 metal binding site [ion binding]; metal-binding site 877468012407 zinc transporter ZupT; Provisional; Region: PRK04201 877468012408 ZIP Zinc transporter; Region: Zip; pfam02535 877468012409 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 877468012410 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 877468012411 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 877468012412 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 877468012413 catalytic residues [active] 877468012414 hinge region; other site 877468012415 alpha helical domain; other site 877468012416 putative disulfide oxidoreductase; Provisional; Region: PRK04307 877468012417 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 877468012418 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 877468012419 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 877468012420 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 877468012421 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 877468012422 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 877468012423 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 877468012424 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 877468012425 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 877468012426 putative ribose interaction site [chemical binding]; other site 877468012427 putative ADP binding site [chemical binding]; other site 877468012428 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 877468012429 active site 877468012430 nucleotide binding site [chemical binding]; other site 877468012431 HIGH motif; other site 877468012432 KMSKS motif; other site 877468012433 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 877468012434 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 877468012435 metal binding triad; other site 877468012436 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 877468012437 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 877468012438 metal binding triad; other site 877468012439 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 877468012440 Uncharacterized conserved protein [Function unknown]; Region: COG3025 877468012441 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 877468012442 putative active site [active] 877468012443 putative metal binding residues [ion binding]; other site 877468012444 signature motif; other site 877468012445 putative triphosphate binding site [ion binding]; other site 877468012446 CHAD domain; Region: CHAD; pfam05235 877468012447 SH3 domain-containing protein; Provisional; Region: PRK10884 877468012448 Bacterial SH3 domain homologues; Region: SH3b; smart00287 877468012449 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 877468012450 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 877468012451 active site 877468012452 NTP binding site [chemical binding]; other site 877468012453 metal binding triad [ion binding]; metal-binding site 877468012454 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 877468012455 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 877468012456 Zn2+ binding site [ion binding]; other site 877468012457 Mg2+ binding site [ion binding]; other site 877468012458 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 877468012459 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 877468012460 homooctamer interface [polypeptide binding]; other site 877468012461 active site 877468012462 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 877468012463 UGMP family protein; Validated; Region: PRK09604 877468012464 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 877468012465 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 877468012466 DNA primase; Validated; Region: dnaG; PRK05667 877468012467 CHC2 zinc finger; Region: zf-CHC2; pfam01807 877468012468 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 877468012469 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 877468012470 active site 877468012471 metal binding site [ion binding]; metal-binding site 877468012472 interdomain interaction site; other site 877468012473 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 877468012474 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 877468012475 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 877468012476 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 877468012477 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 877468012478 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 877468012479 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 877468012480 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 877468012481 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 877468012482 DNA binding residues [nucleotide binding] 877468012483 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 877468012484 active site 877468012485 SUMO-1 interface [polypeptide binding]; other site 877468012486 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 877468012487 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 877468012488 FAD binding pocket [chemical binding]; other site 877468012489 FAD binding motif [chemical binding]; other site 877468012490 phosphate binding motif [ion binding]; other site 877468012491 NAD binding pocket [chemical binding]; other site 877468012492 Predicted transcriptional regulators [Transcription]; Region: COG1695 877468012493 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 877468012494 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 877468012495 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 877468012496 dimerization interface [polypeptide binding]; other site 877468012497 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 877468012498 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 877468012499 dimer interface [polypeptide binding]; other site 877468012500 putative CheW interface [polypeptide binding]; other site 877468012501 PAS fold; Region: PAS_3; pfam08447 877468012502 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 877468012503 putative active site [active] 877468012504 heme pocket [chemical binding]; other site 877468012505 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 877468012506 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 877468012507 dimer interface [polypeptide binding]; other site 877468012508 putative CheW interface [polypeptide binding]; other site 877468012509 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 877468012510 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 877468012511 inhibitor-cofactor binding pocket; inhibition site 877468012512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468012513 catalytic residue [active] 877468012514 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 877468012515 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 877468012516 active site 877468012517 FMN binding site [chemical binding]; other site 877468012518 2,4-decadienoyl-CoA binding site; other site 877468012519 catalytic residue [active] 877468012520 4Fe-4S cluster binding site [ion binding]; other site 877468012521 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 877468012522 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 877468012523 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 877468012524 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 877468012525 S-adenosylmethionine binding site [chemical binding]; other site 877468012526 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 877468012527 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 877468012528 putative active site [active] 877468012529 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 877468012530 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 877468012531 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 877468012532 serine/threonine transporter SstT; Provisional; Region: PRK13628 877468012533 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 877468012534 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 877468012535 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 877468012536 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 877468012537 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 877468012538 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 877468012539 Predicted membrane protein [Function unknown]; Region: COG5393 877468012540 YqjK-like protein; Region: YqjK; pfam13997 877468012541 Predicted membrane protein [Function unknown]; Region: COG2259 877468012542 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 877468012543 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 877468012544 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 877468012545 putative dimer interface [polypeptide binding]; other site 877468012546 N-terminal domain interface [polypeptide binding]; other site 877468012547 putative substrate binding pocket (H-site) [chemical binding]; other site 877468012548 Predicted membrane protein [Function unknown]; Region: COG3152 877468012549 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468012550 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 877468012551 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 877468012552 dimerization interface [polypeptide binding]; other site 877468012553 Pirin-related protein [General function prediction only]; Region: COG1741 877468012554 Pirin; Region: Pirin; pfam02678 877468012555 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 877468012556 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 877468012557 serine transporter; Region: stp; TIGR00814 877468012558 L-serine dehydratase TdcG; Provisional; Region: PRK15040 877468012559 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 877468012560 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 877468012561 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 877468012562 Pyruvate formate lyase 1; Region: PFL1; cd01678 877468012563 coenzyme A binding site [chemical binding]; other site 877468012564 active site 877468012565 catalytic residues [active] 877468012566 glycine loop; other site 877468012567 propionate/acetate kinase; Provisional; Region: PRK12379 877468012568 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 877468012569 threonine/serine transporter TdcC; Provisional; Region: PRK13629 877468012570 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 877468012571 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 877468012572 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 877468012573 tetramer interface [polypeptide binding]; other site 877468012574 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468012575 catalytic residue [active] 877468012576 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 877468012577 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468012578 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 877468012579 putative substrate binding pocket [chemical binding]; other site 877468012580 putative dimerization interface [polypeptide binding]; other site 877468012581 glycerate kinase I; Provisional; Region: PRK10342 877468012582 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 877468012583 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 877468012584 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 877468012585 galactarate dehydratase; Region: galactar-dH20; TIGR03248 877468012586 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 877468012587 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 877468012588 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 877468012589 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 877468012590 intersubunit interface [polypeptide binding]; other site 877468012591 active site 877468012592 zinc binding site [ion binding]; other site 877468012593 Na+ binding site [ion binding]; other site 877468012594 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 877468012595 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 877468012596 active site 877468012597 phosphorylation site [posttranslational modification] 877468012598 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 877468012599 active site 877468012600 P-loop; other site 877468012601 phosphorylation site [posttranslational modification] 877468012602 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 877468012603 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 877468012604 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 877468012605 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 877468012606 putative NAD(P) binding site [chemical binding]; other site 877468012607 catalytic Zn binding site [ion binding]; other site 877468012608 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 877468012609 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 877468012610 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 877468012611 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 877468012612 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 877468012613 putative SAM binding site [chemical binding]; other site 877468012614 putative homodimer interface [polypeptide binding]; other site 877468012615 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 877468012616 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 877468012617 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 877468012618 putative ligand binding site [chemical binding]; other site 877468012619 TIGR00252 family protein; Region: TIGR00252 877468012620 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 877468012621 dimer interface [polypeptide binding]; other site 877468012622 active site 877468012623 outer membrane lipoprotein; Provisional; Region: PRK11023 877468012624 BON domain; Region: BON; pfam04972 877468012625 BON domain; Region: BON; pfam04972 877468012626 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 877468012627 NADH(P)-binding; Region: NAD_binding_10; pfam13460 877468012628 NAD binding site [chemical binding]; other site 877468012629 active site 877468012630 intracellular protease, PfpI family; Region: PfpI; TIGR01382 877468012631 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 877468012632 proposed catalytic triad [active] 877468012633 conserved cys residue [active] 877468012634 hypothetical protein; Provisional; Region: PRK03467 877468012635 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 877468012636 GIY-YIG motif/motif A; other site 877468012637 putative active site [active] 877468012638 putative metal binding site [ion binding]; other site 877468012639 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 877468012640 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 877468012641 Coenzyme A binding pocket [chemical binding]; other site 877468012642 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 877468012643 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 877468012644 Peptidase family U32; Region: Peptidase_U32; pfam01136 877468012645 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 877468012646 putative protease; Provisional; Region: PRK15447 877468012647 hypothetical protein; Provisional; Region: PRK10508 877468012648 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 877468012649 tryptophan permease; Provisional; Region: PRK10483 877468012650 aromatic amino acid transport protein; Region: araaP; TIGR00837 877468012651 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 877468012652 DEAD-like helicases superfamily; Region: DEXDc; smart00487 877468012653 ATP binding site [chemical binding]; other site 877468012654 Mg++ binding site [ion binding]; other site 877468012655 motif III; other site 877468012656 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 877468012657 nucleotide binding region [chemical binding]; other site 877468012658 ATP-binding site [chemical binding]; other site 877468012659 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 877468012660 putative RNA binding site [nucleotide binding]; other site 877468012661 lipoprotein NlpI; Provisional; Region: PRK11189 877468012662 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 877468012663 binding surface 877468012664 TPR motif; other site 877468012665 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 877468012666 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 877468012667 RNase E interface [polypeptide binding]; other site 877468012668 trimer interface [polypeptide binding]; other site 877468012669 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 877468012670 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 877468012671 RNase E interface [polypeptide binding]; other site 877468012672 trimer interface [polypeptide binding]; other site 877468012673 active site 877468012674 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 877468012675 putative nucleic acid binding region [nucleotide binding]; other site 877468012676 G-X-X-G motif; other site 877468012677 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 877468012678 RNA binding site [nucleotide binding]; other site 877468012679 domain interface; other site 877468012680 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 877468012681 16S/18S rRNA binding site [nucleotide binding]; other site 877468012682 S13e-L30e interaction site [polypeptide binding]; other site 877468012683 25S rRNA binding site [nucleotide binding]; other site 877468012684 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 877468012685 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 877468012686 RNA binding site [nucleotide binding]; other site 877468012687 active site 877468012688 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 877468012689 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 877468012690 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 877468012691 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 877468012692 translation initiation factor IF-2; Region: IF-2; TIGR00487 877468012693 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 877468012694 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 877468012695 G1 box; other site 877468012696 putative GEF interaction site [polypeptide binding]; other site 877468012697 GTP/Mg2+ binding site [chemical binding]; other site 877468012698 Switch I region; other site 877468012699 G2 box; other site 877468012700 G3 box; other site 877468012701 Switch II region; other site 877468012702 G4 box; other site 877468012703 G5 box; other site 877468012704 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 877468012705 Translation-initiation factor 2; Region: IF-2; pfam11987 877468012706 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 877468012707 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 877468012708 NusA N-terminal domain; Region: NusA_N; pfam08529 877468012709 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 877468012710 RNA binding site [nucleotide binding]; other site 877468012711 homodimer interface [polypeptide binding]; other site 877468012712 NusA-like KH domain; Region: KH_5; pfam13184 877468012713 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 877468012714 G-X-X-G motif; other site 877468012715 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 877468012716 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 877468012717 ribosome maturation protein RimP; Reviewed; Region: PRK00092 877468012718 hypothetical protein; Provisional; Region: PRK14641 877468012719 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 877468012720 putative oligomer interface [polypeptide binding]; other site 877468012721 putative RNA binding site [nucleotide binding]; other site 877468012722 argininosuccinate synthase; Validated; Region: PRK05370 877468012723 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 877468012724 Preprotein translocase SecG subunit; Region: SecG; pfam03840 877468012725 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 877468012726 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 877468012727 active site 877468012728 substrate binding site [chemical binding]; other site 877468012729 metal binding site [ion binding]; metal-binding site 877468012730 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 877468012731 dihydropteroate synthase; Region: DHPS; TIGR01496 877468012732 substrate binding pocket [chemical binding]; other site 877468012733 dimer interface [polypeptide binding]; other site 877468012734 inhibitor binding site; inhibition site 877468012735 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 877468012736 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 877468012737 Walker A motif; other site 877468012738 ATP binding site [chemical binding]; other site 877468012739 Walker B motif; other site 877468012740 arginine finger; other site 877468012741 Peptidase family M41; Region: Peptidase_M41; pfam01434 877468012742 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 877468012743 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 877468012744 S-adenosylmethionine binding site [chemical binding]; other site 877468012745 RNA-binding protein YhbY; Provisional; Region: PRK10343 877468012746 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 877468012747 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 877468012748 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 877468012749 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 877468012750 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 877468012751 GTPase CgtA; Reviewed; Region: obgE; PRK12298 877468012752 GTP1/OBG; Region: GTP1_OBG; pfam01018 877468012753 Obg GTPase; Region: Obg; cd01898 877468012754 G1 box; other site 877468012755 GTP/Mg2+ binding site [chemical binding]; other site 877468012756 Switch I region; other site 877468012757 G2 box; other site 877468012758 G3 box; other site 877468012759 Switch II region; other site 877468012760 G4 box; other site 877468012761 G5 box; other site 877468012762 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 877468012763 EamA-like transporter family; Region: EamA; pfam00892 877468012764 EamA-like transporter family; Region: EamA; pfam00892 877468012765 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 877468012766 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 877468012767 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 877468012768 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 877468012769 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 877468012770 substrate binding pocket [chemical binding]; other site 877468012771 chain length determination region; other site 877468012772 substrate-Mg2+ binding site; other site 877468012773 catalytic residues [active] 877468012774 aspartate-rich region 1; other site 877468012775 active site lid residues [active] 877468012776 aspartate-rich region 2; other site 877468012777 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 877468012778 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 877468012779 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 877468012780 hinge; other site 877468012781 active site 877468012782 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 877468012783 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 877468012784 anti sigma factor interaction site; other site 877468012785 regulatory phosphorylation site [posttranslational modification]; other site 877468012786 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 877468012787 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 877468012788 mce related protein; Region: MCE; pfam02470 877468012789 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 877468012790 conserved hypothetical integral membrane protein; Region: TIGR00056 877468012791 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 877468012792 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 877468012793 Walker A/P-loop; other site 877468012794 ATP binding site [chemical binding]; other site 877468012795 Q-loop/lid; other site 877468012796 ABC transporter signature motif; other site 877468012797 Walker B; other site 877468012798 D-loop; other site 877468012799 H-loop/switch region; other site 877468012800 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 877468012801 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 877468012802 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 877468012803 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 877468012804 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 877468012805 putative active site [active] 877468012806 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 877468012807 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 877468012808 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 877468012809 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 877468012810 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 877468012811 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 877468012812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 877468012813 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 877468012814 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 877468012815 Walker A/P-loop; other site 877468012816 ATP binding site [chemical binding]; other site 877468012817 Q-loop/lid; other site 877468012818 ABC transporter signature motif; other site 877468012819 Walker B; other site 877468012820 D-loop; other site 877468012821 H-loop/switch region; other site 877468012822 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 877468012823 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 877468012824 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 877468012825 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 877468012826 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 877468012827 30S subunit binding site; other site 877468012828 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 877468012829 active site 877468012830 phosphorylation site [posttranslational modification] 877468012831 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 877468012832 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 877468012833 regulatory protein interface [polypeptide binding]; other site 877468012834 regulatory phosphorylation site [posttranslational modification]; other site 877468012835 hypothetical protein; Provisional; Region: PRK10345 877468012836 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 877468012837 Transglycosylase; Region: Transgly; cl17702 877468012838 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 877468012839 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 877468012840 conserved cys residue [active] 877468012841 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 877468012842 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 877468012843 putative active site [active] 877468012844 heme pocket [chemical binding]; other site 877468012845 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 877468012846 dimer interface [polypeptide binding]; other site 877468012847 phosphorylation site [posttranslational modification] 877468012848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 877468012849 ATP binding site [chemical binding]; other site 877468012850 Mg2+ binding site [ion binding]; other site 877468012851 G-X-G motif; other site 877468012852 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 877468012853 active site 877468012854 phosphorylation site [posttranslational modification] 877468012855 intermolecular recognition site; other site 877468012856 dimerization interface [polypeptide binding]; other site 877468012857 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 877468012858 putative binding surface; other site 877468012859 active site 877468012860 radical SAM protein, TIGR01212 family; Region: TIGR01212 877468012861 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 877468012862 FeS/SAM binding site; other site 877468012863 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 877468012864 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 877468012865 active site 877468012866 dimer interface [polypeptide binding]; other site 877468012867 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 877468012868 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 877468012869 active site 877468012870 FMN binding site [chemical binding]; other site 877468012871 substrate binding site [chemical binding]; other site 877468012872 3Fe-4S cluster binding site [ion binding]; other site 877468012873 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 877468012874 domain interface; other site 877468012875 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 877468012876 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 877468012877 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 877468012878 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 877468012879 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 877468012880 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 877468012881 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 877468012882 Na binding site [ion binding]; other site 877468012883 putative substrate binding site [chemical binding]; other site 877468012884 cytosine deaminase; Provisional; Region: PRK09230 877468012885 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 877468012886 active site 877468012887 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 877468012888 N-acetylmannosamine kinase; Provisional; Region: PRK05082 877468012889 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 877468012890 nucleotide binding site [chemical binding]; other site 877468012891 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 877468012892 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 877468012893 putative active site cavity [active] 877468012894 putative sialic acid transporter; Provisional; Region: PRK03893 877468012895 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468012896 putative substrate translocation pore; other site 877468012897 N-acetylneuraminate lyase; Provisional; Region: PRK04147 877468012898 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 877468012899 inhibitor site; inhibition site 877468012900 active site 877468012901 dimer interface [polypeptide binding]; other site 877468012902 catalytic residue [active] 877468012903 transcriptional regulator NanR; Provisional; Region: PRK03837 877468012904 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 877468012905 DNA-binding site [nucleotide binding]; DNA binding site 877468012906 FCD domain; Region: FCD; pfam07729 877468012907 Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969 877468012908 stringent starvation protein A; Provisional; Region: sspA; PRK09481 877468012909 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 877468012910 C-terminal domain interface [polypeptide binding]; other site 877468012911 putative GSH binding site (G-site) [chemical binding]; other site 877468012912 dimer interface [polypeptide binding]; other site 877468012913 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 877468012914 dimer interface [polypeptide binding]; other site 877468012915 N-terminal domain interface [polypeptide binding]; other site 877468012916 Family of unknown function (DUF695); Region: DUF695; pfam05117 877468012917 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 877468012918 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 877468012919 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 877468012920 23S rRNA interface [nucleotide binding]; other site 877468012921 L3 interface [polypeptide binding]; other site 877468012922 Predicted ATPase [General function prediction only]; Region: COG1485 877468012923 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 877468012924 hypothetical protein; Provisional; Region: PRK11677 877468012925 serine endoprotease; Provisional; Region: PRK10139 877468012926 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 877468012927 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 877468012928 protein binding site [polypeptide binding]; other site 877468012929 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 877468012930 serine endoprotease; Provisional; Region: PRK10898 877468012931 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 877468012932 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 877468012933 Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767 877468012934 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 877468012935 oxaloacetate decarboxylase; Provisional; Region: PRK14040 877468012936 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 877468012937 active site 877468012938 catalytic residues [active] 877468012939 metal binding site [ion binding]; metal-binding site 877468012940 homodimer binding site [polypeptide binding]; other site 877468012941 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 877468012942 carboxyltransferase (CT) interaction site; other site 877468012943 biotinylation site [posttranslational modification]; other site 877468012944 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 877468012945 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 877468012946 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 877468012947 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 877468012948 transmembrane helices; other site 877468012949 Citrate transporter; Region: CitMHS; pfam03600 877468012950 Transcriptional regulators [Transcription]; Region: GntR; COG1802 877468012951 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 877468012952 DNA-binding site [nucleotide binding]; DNA binding site 877468012953 FCD domain; Region: FCD; pfam07729 877468012954 Transcriptional regulators [Transcription]; Region: GntR; COG1802 877468012955 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 877468012956 DNA-binding site [nucleotide binding]; DNA binding site 877468012957 malate dehydrogenase; Provisional; Region: PRK05086 877468012958 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 877468012959 NAD binding site [chemical binding]; other site 877468012960 dimerization interface [polypeptide binding]; other site 877468012961 Substrate binding site [chemical binding]; other site 877468012962 arginine repressor; Provisional; Region: PRK05066 877468012963 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 877468012964 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 877468012965 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 877468012966 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 877468012967 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 877468012968 RNAase interaction site [polypeptide binding]; other site 877468012969 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 877468012970 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 877468012971 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 877468012972 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 877468012973 HlyD family secretion protein; Region: HlyD_3; pfam13437 877468012974 efflux system membrane protein; Provisional; Region: PRK11594 877468012975 transcriptional regulator; Provisional; Region: PRK10632 877468012976 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468012977 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 877468012978 putative effector binding pocket; other site 877468012979 dimerization interface [polypeptide binding]; other site 877468012980 protease TldD; Provisional; Region: tldD; PRK10735 877468012981 hypothetical protein; Provisional; Region: PRK10899 877468012982 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 877468012983 ribonuclease G; Provisional; Region: PRK11712 877468012984 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 877468012985 homodimer interface [polypeptide binding]; other site 877468012986 oligonucleotide binding site [chemical binding]; other site 877468012987 Maf-like protein; Region: Maf; pfam02545 877468012988 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 877468012989 active site 877468012990 dimer interface [polypeptide binding]; other site 877468012991 rod shape-determining protein MreD; Provisional; Region: PRK11060 877468012992 rod shape-determining protein MreC; Region: mreC; TIGR00219 877468012993 rod shape-determining protein MreC; Region: MreC; pfam04085 877468012994 rod shape-determining protein MreB; Provisional; Region: PRK13927 877468012995 MreB and similar proteins; Region: MreB_like; cd10225 877468012996 nucleotide binding site [chemical binding]; other site 877468012997 Mg binding site [ion binding]; other site 877468012998 putative protofilament interaction site [polypeptide binding]; other site 877468012999 RodZ interaction site [polypeptide binding]; other site 877468013000 regulatory protein CsrD; Provisional; Region: PRK11059 877468013001 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 877468013002 metal binding site [ion binding]; metal-binding site 877468013003 active site 877468013004 I-site; other site 877468013005 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 877468013006 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 877468013007 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 877468013008 NADP binding site [chemical binding]; other site 877468013009 dimer interface [polypeptide binding]; other site 877468013010 TMAO/DMSO reductase; Reviewed; Region: PRK05363 877468013011 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 877468013012 Moco binding site; other site 877468013013 metal coordination site [ion binding]; other site 877468013014 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 877468013015 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 877468013016 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 877468013017 carboxyltransferase (CT) interaction site; other site 877468013018 biotinylation site [posttranslational modification]; other site 877468013019 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 877468013020 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 877468013021 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 877468013022 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 877468013023 hypothetical protein; Provisional; Region: PRK10633 877468013024 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 877468013025 Na binding site [ion binding]; other site 877468013026 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 877468013027 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 877468013028 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 877468013029 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 877468013030 FMN binding site [chemical binding]; other site 877468013031 active site 877468013032 catalytic residues [active] 877468013033 substrate binding site [chemical binding]; other site 877468013034 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 877468013035 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 877468013036 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 877468013037 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 877468013038 DNA methylase; Region: N6_N4_Mtase; pfam01555 877468013039 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 877468013040 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 877468013041 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 877468013042 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 877468013043 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 877468013044 metal binding site [ion binding]; metal-binding site 877468013045 active site 877468013046 I-site; other site 877468013047 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 877468013048 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 877468013049 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 877468013050 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 877468013051 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 877468013052 HlyD family secretion protein; Region: HlyD; pfam00529 877468013053 HlyD family secretion protein; Region: HlyD_3; pfam13437 877468013054 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 877468013055 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 877468013056 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 877468013057 purine monophosphate binding site [chemical binding]; other site 877468013058 dimer interface [polypeptide binding]; other site 877468013059 putative catalytic residues [active] 877468013060 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 877468013061 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 877468013062 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 877468013063 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 877468013064 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 877468013065 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 877468013066 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 877468013067 active site 877468013068 phosphorylation site [posttranslational modification] 877468013069 intermolecular recognition site; other site 877468013070 dimerization interface [polypeptide binding]; other site 877468013071 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 877468013072 Walker A motif; other site 877468013073 ATP binding site [chemical binding]; other site 877468013074 Walker B motif; other site 877468013075 arginine finger; other site 877468013076 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 877468013077 sensor protein ZraS; Provisional; Region: PRK10364 877468013078 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 877468013079 dimer interface [polypeptide binding]; other site 877468013080 phosphorylation site [posttranslational modification] 877468013081 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 877468013082 ATP binding site [chemical binding]; other site 877468013083 Mg2+ binding site [ion binding]; other site 877468013084 G-X-G motif; other site 877468013085 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 877468013086 dimer interface [polypeptide binding]; other site 877468013087 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 877468013088 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 877468013089 IHF dimer interface [polypeptide binding]; other site 877468013090 IHF - DNA interface [nucleotide binding]; other site 877468013091 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 877468013092 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 877468013093 Active_site [active] 877468013094 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 877468013095 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 877468013096 substrate binding site [chemical binding]; other site 877468013097 active site 877468013098 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 877468013099 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 877468013100 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 877468013101 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 877468013102 putative NADH binding site [chemical binding]; other site 877468013103 putative active site [active] 877468013104 nudix motif; other site 877468013105 putative metal binding site [ion binding]; other site 877468013106 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 877468013107 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 877468013108 ThiC-associated domain; Region: ThiC-associated; pfam13667 877468013109 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 877468013110 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 877468013111 thiamine phosphate binding site [chemical binding]; other site 877468013112 active site 877468013113 pyrophosphate binding site [ion binding]; other site 877468013114 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 877468013115 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 877468013116 ATP binding site [chemical binding]; other site 877468013117 substrate interface [chemical binding]; other site 877468013118 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 877468013119 thiS-thiF/thiG interaction site; other site 877468013120 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 877468013121 ThiS interaction site; other site 877468013122 putative active site [active] 877468013123 tetramer interface [polypeptide binding]; other site 877468013124 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 877468013125 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 877468013126 FeS/SAM binding site; other site 877468013127 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 877468013128 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 877468013129 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 877468013130 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 877468013131 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 877468013132 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 877468013133 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 877468013134 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 877468013135 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 877468013136 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 877468013137 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 877468013138 DNA binding site [nucleotide binding] 877468013139 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 877468013140 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 877468013141 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 877468013142 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 877468013143 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 877468013144 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 877468013145 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 877468013146 RPB3 interaction site [polypeptide binding]; other site 877468013147 RPB1 interaction site [polypeptide binding]; other site 877468013148 RPB11 interaction site [polypeptide binding]; other site 877468013149 RPB10 interaction site [polypeptide binding]; other site 877468013150 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 877468013151 core dimer interface [polypeptide binding]; other site 877468013152 peripheral dimer interface [polypeptide binding]; other site 877468013153 L10 interface [polypeptide binding]; other site 877468013154 L11 interface [polypeptide binding]; other site 877468013155 putative EF-Tu interaction site [polypeptide binding]; other site 877468013156 putative EF-G interaction site [polypeptide binding]; other site 877468013157 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 877468013158 23S rRNA interface [nucleotide binding]; other site 877468013159 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 877468013160 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 877468013161 mRNA/rRNA interface [nucleotide binding]; other site 877468013162 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 877468013163 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 877468013164 L7/L12 interface [polypeptide binding]; other site 877468013165 23S rRNA interface [nucleotide binding]; other site 877468013166 L25 interface [polypeptide binding]; other site 877468013167 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 877468013168 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 877468013169 putative homodimer interface [polypeptide binding]; other site 877468013170 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 877468013171 heterodimer interface [polypeptide binding]; other site 877468013172 homodimer interface [polypeptide binding]; other site 877468013173 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 877468013174 elongation factor Tu; Reviewed; Region: PRK00049 877468013175 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 877468013176 G1 box; other site 877468013177 GEF interaction site [polypeptide binding]; other site 877468013178 GTP/Mg2+ binding site [chemical binding]; other site 877468013179 Switch I region; other site 877468013180 G2 box; other site 877468013181 G3 box; other site 877468013182 Switch II region; other site 877468013183 G4 box; other site 877468013184 G5 box; other site 877468013185 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 877468013186 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 877468013187 Antibiotic Binding Site [chemical binding]; other site 877468013188 pantothenate kinase; Provisional; Region: PRK05439 877468013189 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 877468013190 ATP-binding site [chemical binding]; other site 877468013191 CoA-binding site [chemical binding]; other site 877468013192 Mg2+-binding site [ion binding]; other site 877468013193 Biotin operon repressor [Transcription]; Region: BirA; COG1654 877468013194 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 877468013195 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 877468013196 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 877468013197 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 877468013198 FAD binding domain; Region: FAD_binding_4; pfam01565 877468013199 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 877468013200 glutamate racemase; Provisional; Region: PRK00865 877468013201 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 877468013202 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 877468013203 N-terminal plug; other site 877468013204 ligand-binding site [chemical binding]; other site 877468013205 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 877468013206 Protein of unknown function (DUF3164); Region: DUF3164; pfam11363 877468013207 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 877468013208 S-adenosylmethionine binding site [chemical binding]; other site 877468013209 hypothetical protein; Provisional; Region: PRK11056 877468013210 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 877468013211 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 877468013212 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 877468013213 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 877468013214 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 877468013215 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 877468013216 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468013217 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 877468013218 dimerization interface [polypeptide binding]; other site 877468013219 argininosuccinate lyase; Provisional; Region: PRK04833 877468013220 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 877468013221 active sites [active] 877468013222 tetramer interface [polypeptide binding]; other site 877468013223 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 877468013224 nucleotide binding site [chemical binding]; other site 877468013225 N-acetyl-L-glutamate binding site [chemical binding]; other site 877468013226 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 877468013227 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 877468013228 acetylornithine deacetylase; Provisional; Region: PRK05111 877468013229 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 877468013230 metal binding site [ion binding]; metal-binding site 877468013231 putative dimer interface [polypeptide binding]; other site 877468013232 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 877468013233 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 877468013234 hypothetical protein; Provisional; Region: PRK10649 877468013235 Sulfatase; Region: Sulfatase; pfam00884 877468013236 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 877468013237 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 877468013238 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 877468013239 active site 877468013240 P-loop; other site 877468013241 phosphorylation site [posttranslational modification] 877468013242 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 877468013243 FeS/SAM binding site; other site 877468013244 pyruvate formate lyase II activase; Provisional; Region: PRK10076 877468013245 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 877468013246 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 877468013247 dimer interface [polypeptide binding]; other site 877468013248 active site 877468013249 glycine loop; other site 877468013250 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 877468013251 active site 877468013252 P-loop; other site 877468013253 phosphorylation site [posttranslational modification] 877468013254 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 877468013255 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 877468013256 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 877468013257 dimerization domain swap beta strand [polypeptide binding]; other site 877468013258 regulatory protein interface [polypeptide binding]; other site 877468013259 active site 877468013260 regulatory phosphorylation site [posttranslational modification]; other site 877468013261 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 877468013262 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 877468013263 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 877468013264 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 877468013265 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 877468013266 active site 877468013267 phosphorylation site [posttranslational modification] 877468013268 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 877468013269 active site 877468013270 intersubunit interactions; other site 877468013271 catalytic residue [active] 877468013272 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 877468013273 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 877468013274 dimer interface [polypeptide binding]; other site 877468013275 active site 877468013276 metal binding site [ion binding]; metal-binding site 877468013277 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 877468013278 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 877468013279 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 877468013280 heme binding site [chemical binding]; other site 877468013281 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 877468013282 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 877468013283 FAD binding site [chemical binding]; other site 877468013284 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 877468013285 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 877468013286 active site 877468013287 metal binding site [ion binding]; metal-binding site 877468013288 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 877468013289 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 877468013290 mechanosensitive channel MscS; Provisional; Region: PRK10334 877468013291 Conserved TM helix; Region: TM_helix; pfam05552 877468013292 Mechanosensitive ion channel; Region: MS_channel; pfam00924 877468013293 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 877468013294 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 877468013295 putative catalytic residues [active] 877468013296 putative nucleotide binding site [chemical binding]; other site 877468013297 putative aspartate binding site [chemical binding]; other site 877468013298 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 877468013299 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 877468013300 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 877468013301 cystathionine gamma-synthase; Provisional; Region: PRK08045 877468013302 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 877468013303 homodimer interface [polypeptide binding]; other site 877468013304 substrate-cofactor binding pocket; other site 877468013305 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468013306 catalytic residue [active] 877468013307 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 877468013308 dimerization interface [polypeptide binding]; other site 877468013309 DNA binding site [nucleotide binding] 877468013310 corepressor binding sites; other site 877468013311 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 877468013312 conserved hypothetical protein; Region: chp_urease_rgn; TIGR02117 877468013313 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 877468013314 primosome assembly protein PriA; Validated; Region: PRK05580 877468013315 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 877468013316 ATP binding site [chemical binding]; other site 877468013317 putative Mg++ binding site [ion binding]; other site 877468013318 helicase superfamily c-terminal domain; Region: HELICc; smart00490 877468013319 ATP-binding site [chemical binding]; other site 877468013320 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 877468013321 DNA binding site [nucleotide binding] 877468013322 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 877468013323 domain linker motif; other site 877468013324 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 877468013325 dimerization interface [polypeptide binding]; other site 877468013326 ligand binding site [chemical binding]; other site 877468013327 essential cell division protein FtsN; Provisional; Region: PRK10927 877468013328 cell division protein FtsN; Provisional; Region: PRK12757 877468013329 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 877468013330 active site 877468013331 HslU subunit interaction site [polypeptide binding]; other site 877468013332 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 877468013333 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 877468013334 Walker A motif; other site 877468013335 ATP binding site [chemical binding]; other site 877468013336 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 877468013337 Walker B motif; other site 877468013338 arginine finger; other site 877468013339 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 877468013340 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 877468013341 UbiA prenyltransferase family; Region: UbiA; pfam01040 877468013342 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 877468013343 septal ring assembly protein ZapB; Provisional; Region: PRK15422 877468013344 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 877468013345 amphipathic channel; other site 877468013346 Asn-Pro-Ala signature motifs; other site 877468013347 glycerol kinase; Provisional; Region: glpK; PRK00047 877468013348 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 877468013349 N- and C-terminal domain interface [polypeptide binding]; other site 877468013350 active site 877468013351 MgATP binding site [chemical binding]; other site 877468013352 catalytic site [active] 877468013353 metal binding site [ion binding]; metal-binding site 877468013354 glycerol binding site [chemical binding]; other site 877468013355 homotetramer interface [polypeptide binding]; other site 877468013356 homodimer interface [polypeptide binding]; other site 877468013357 FBP binding site [chemical binding]; other site 877468013358 protein IIAGlc interface [polypeptide binding]; other site 877468013359 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 877468013360 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 877468013361 putative active site [active] 877468013362 ferredoxin-NADP reductase; Provisional; Region: PRK10926 877468013363 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 877468013364 FAD binding pocket [chemical binding]; other site 877468013365 FAD binding motif [chemical binding]; other site 877468013366 phosphate binding motif [ion binding]; other site 877468013367 beta-alpha-beta structure motif; other site 877468013368 NAD binding pocket [chemical binding]; other site 877468013369 Predicted membrane protein [Function unknown]; Region: COG3152 877468013370 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 877468013371 triosephosphate isomerase; Provisional; Region: PRK14567 877468013372 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 877468013373 substrate binding site [chemical binding]; other site 877468013374 dimer interface [polypeptide binding]; other site 877468013375 catalytic triad [active] 877468013376 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 877468013377 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 877468013378 substrate binding site [chemical binding]; other site 877468013379 hexamer interface [polypeptide binding]; other site 877468013380 metal binding site [ion binding]; metal-binding site 877468013381 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 877468013382 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 877468013383 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 877468013384 putative active site; other site 877468013385 catalytic residue [active] 877468013386 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 877468013387 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 877468013388 ligand binding site [chemical binding]; other site 877468013389 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 877468013390 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 877468013391 TM-ABC transporter signature motif; other site 877468013392 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 877468013393 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 877468013394 TM-ABC transporter signature motif; other site 877468013395 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 877468013396 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 877468013397 Walker A/P-loop; other site 877468013398 ATP binding site [chemical binding]; other site 877468013399 Q-loop/lid; other site 877468013400 ABC transporter signature motif; other site 877468013401 Walker B; other site 877468013402 D-loop; other site 877468013403 H-loop/switch region; other site 877468013404 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 877468013405 transcriptional regulator LsrR; Provisional; Region: PRK15418 877468013406 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 877468013407 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 877468013408 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 877468013409 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 877468013410 putative N- and C-terminal domain interface [polypeptide binding]; other site 877468013411 putative active site [active] 877468013412 putative MgATP binding site [chemical binding]; other site 877468013413 catalytic site [active] 877468013414 metal binding site [ion binding]; metal-binding site 877468013415 putative carbohydrate binding site [chemical binding]; other site 877468013416 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 877468013417 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 877468013418 CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934 877468013419 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 877468013420 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 877468013421 DNA-binding site [nucleotide binding]; DNA binding site 877468013422 Alanine racemase, C-terminal domain; Region: Ala_racemase_C; cl08293 877468013423 UTRA domain; Region: UTRA; pfam07702 877468013424 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 877468013425 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 877468013426 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 877468013427 putative substrate binding site [chemical binding]; other site 877468013428 putative ATP binding site [chemical binding]; other site 877468013429 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 877468013430 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 877468013431 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 877468013432 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 877468013433 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 877468013434 substrate binding pocket [chemical binding]; other site 877468013435 membrane-bound complex binding site; other site 877468013436 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 877468013437 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 877468013438 active site 877468013439 ADP/pyrophosphate binding site [chemical binding]; other site 877468013440 dimerization interface [polypeptide binding]; other site 877468013441 allosteric effector site; other site 877468013442 fructose-1,6-bisphosphate binding site; other site 877468013443 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 877468013444 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 877468013445 tail protein; Provisional; Region: D; PHA02561 877468013446 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 877468013447 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 877468013448 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 877468013449 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 877468013450 major tail tube protein; Provisional; Region: FII; PHA02600 877468013451 major tail sheath protein; Provisional; Region: FI; PHA02560 877468013452 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 877468013453 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 877468013454 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 877468013455 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 877468013456 Phage Tail Collar Domain; Region: Collar; pfam07484 877468013457 phage tail protein, P2 protein I family; Region: tail_P2_I; TIGR01634 877468013458 baseplate assembly protein; Provisional; Region: J; PHA02568 877468013459 baseplate wedge subunit; Provisional; Region: W; PHA02516 877468013460 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 877468013461 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 877468013462 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 877468013463 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 877468013464 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 877468013465 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 877468013466 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 877468013467 catalytic residues [active] 877468013468 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 877468013469 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 877468013470 terminase endonuclease subunit; Provisional; Region: M; PHA02537 877468013471 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 877468013472 capsid protein; Provisional; Region: N; PHA02538 877468013473 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 877468013474 terminase ATPase subunit; Provisional; Region: P; PHA02535 877468013475 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 877468013476 portal vertex protein; Provisional; Region: Q; PHA02536 877468013477 Phage portal protein; Region: Phage_portal; pfam04860 877468013478 Fic/DOC family; Region: Fic; pfam02661 877468013479 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 877468013480 Regulatory phage protein cox; Region: Phage_Cox; pfam10743 877468013481 integrase; Provisional; Region: int; PHA02601 877468013482 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 877468013483 active site 877468013484 DNA binding site [nucleotide binding] 877468013485 Int/Topo IB signature motif; other site 877468013486 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 877468013487 dimer interface [polypeptide binding]; other site 877468013488 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 877468013489 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 877468013490 active site 877468013491 intermolecular recognition site; other site 877468013492 dimerization interface [polypeptide binding]; other site 877468013493 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 877468013494 DNA binding site [nucleotide binding] 877468013495 two-component sensor protein; Provisional; Region: cpxA; PRK09470 877468013496 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 877468013497 dimerization interface [polypeptide binding]; other site 877468013498 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 877468013499 dimer interface [polypeptide binding]; other site 877468013500 phosphorylation site [posttranslational modification] 877468013501 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 877468013502 ATP binding site [chemical binding]; other site 877468013503 Mg2+ binding site [ion binding]; other site 877468013504 G-X-G motif; other site 877468013505 SnoaL-like domain; Region: SnoaL_2; pfam12680 877468013506 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 877468013507 MOSC domain; Region: MOSC; pfam03473 877468013508 3-alpha domain; Region: 3-alpha; pfam03475 877468013509 superoxide dismutase; Provisional; Region: PRK10925 877468013510 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 877468013511 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 877468013512 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 877468013513 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 877468013514 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 877468013515 DctM-like transporters; Region: DctM; pfam06808 877468013516 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 877468013517 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178 877468013518 L-rhamnose-proton symport protein (RhaT); Region: RhaT; pfam06379 877468013519 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 877468013520 transcriptional activator RhaR; Provisional; Region: PRK13502 877468013521 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 877468013522 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 877468013523 transcriptional activator RhaS; Provisional; Region: PRK13503 877468013524 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 877468013525 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 877468013526 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 877468013527 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 877468013528 N- and C-terminal domain interface [polypeptide binding]; other site 877468013529 active site 877468013530 putative catalytic site [active] 877468013531 metal binding site [ion binding]; metal-binding site 877468013532 ATP binding site [chemical binding]; other site 877468013533 rhamnulokinase; Provisional; Region: rhaB; PRK10640 877468013534 carbohydrate binding site [chemical binding]; other site 877468013535 L-rhamnose isomerase; Provisional; Region: PRK01076 877468013536 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 877468013537 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 877468013538 intersubunit interface [polypeptide binding]; other site 877468013539 active site 877468013540 Zn2+ binding site [ion binding]; other site 877468013541 lactaldehyde reductase; Region: lactal_redase; TIGR02638 877468013542 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 877468013543 dimer interface [polypeptide binding]; other site 877468013544 active site 877468013545 metal binding site [ion binding]; metal-binding site 877468013546 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 877468013547 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 877468013548 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 877468013549 non-specific DNA binding site [nucleotide binding]; other site 877468013550 salt bridge; other site 877468013551 sequence-specific DNA binding site [nucleotide binding]; other site 877468013552 Cupin domain; Region: Cupin_2; cl17218 877468013553 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 877468013554 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 877468013555 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 877468013556 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 877468013557 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 877468013558 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 877468013559 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 877468013560 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 877468013561 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 877468013562 molybdopterin cofactor binding site; other site 877468013563 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 877468013564 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 877468013565 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 877468013566 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 877468013567 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 877468013568 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 877468013569 Predicted transcriptional regulator [Transcription]; Region: COG2944 877468013570 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 877468013571 non-specific DNA binding site [nucleotide binding]; other site 877468013572 salt bridge; other site 877468013573 sequence-specific DNA binding site [nucleotide binding]; other site 877468013574 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 877468013575 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 877468013576 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 877468013577 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 877468013578 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 877468013579 non-specific DNA binding site [nucleotide binding]; other site 877468013580 salt bridge; other site 877468013581 sequence-specific DNA binding site [nucleotide binding]; other site 877468013582 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 877468013583 Coenzyme A binding pocket [chemical binding]; other site 877468013584 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 877468013585 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 877468013586 putative active site [active] 877468013587 dimerization interface [polypeptide binding]; other site 877468013588 putative tRNAtyr binding site [nucleotide binding]; other site 877468013589 hypothetical protein; Reviewed; Region: PRK01637 877468013590 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 877468013591 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 877468013592 motif II; other site 877468013593 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 877468013594 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 877468013595 putative DNA binding site [nucleotide binding]; other site 877468013596 putative Zn2+ binding site [ion binding]; other site 877468013597 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 877468013598 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 877468013599 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 877468013600 substrate binding site [chemical binding]; other site 877468013601 ATP binding site [chemical binding]; other site 877468013602 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 877468013603 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 877468013604 Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684 877468013605 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 877468013606 dimerization interface [polypeptide binding]; other site 877468013607 putative active cleft [active] 877468013608 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 877468013609 active site 877468013610 catalytic residues [active] 877468013611 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 877468013612 alpha-glucosidase; Provisional; Region: PRK10426 877468013613 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 877468013614 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 877468013615 putative active site [active] 877468013616 putative catalytic site [active] 877468013617 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 877468013618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468013619 putative substrate translocation pore; other site 877468013620 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 877468013621 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 877468013622 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 877468013623 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 877468013624 GTP-binding protein; Provisional; Region: PRK10218 877468013625 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 877468013626 G1 box; other site 877468013627 putative GEF interaction site [polypeptide binding]; other site 877468013628 GTP/Mg2+ binding site [chemical binding]; other site 877468013629 Switch I region; other site 877468013630 G2 box; other site 877468013631 G3 box; other site 877468013632 Switch II region; other site 877468013633 G4 box; other site 877468013634 G5 box; other site 877468013635 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 877468013636 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 877468013637 glutamine synthetase; Provisional; Region: glnA; PRK09469 877468013638 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 877468013639 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 877468013640 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 877468013641 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 877468013642 putative active site [active] 877468013643 heme pocket [chemical binding]; other site 877468013644 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 877468013645 dimer interface [polypeptide binding]; other site 877468013646 phosphorylation site [posttranslational modification] 877468013647 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 877468013648 ATP binding site [chemical binding]; other site 877468013649 Mg2+ binding site [ion binding]; other site 877468013650 G-X-G motif; other site 877468013651 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 877468013652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 877468013653 active site 877468013654 phosphorylation site [posttranslational modification] 877468013655 intermolecular recognition site; other site 877468013656 dimerization interface [polypeptide binding]; other site 877468013657 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 877468013658 Walker A motif; other site 877468013659 ATP binding site [chemical binding]; other site 877468013660 Walker B motif; other site 877468013661 arginine finger; other site 877468013662 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 877468013663 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 877468013664 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 877468013665 FeS/SAM binding site; other site 877468013666 HemN C-terminal domain; Region: HemN_C; pfam06969 877468013667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 877468013668 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 877468013669 G1 box; other site 877468013670 GTP/Mg2+ binding site [chemical binding]; other site 877468013671 Switch I region; other site 877468013672 G2 box; other site 877468013673 G3 box; other site 877468013674 Switch II region; other site 877468013675 G4 box; other site 877468013676 G5 box; other site 877468013677 DNA polymerase I; Provisional; Region: PRK05755 877468013678 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 877468013679 active site 877468013680 metal binding site 1 [ion binding]; metal-binding site 877468013681 putative 5' ssDNA interaction site; other site 877468013682 metal binding site 3; metal-binding site 877468013683 metal binding site 2 [ion binding]; metal-binding site 877468013684 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 877468013685 putative DNA binding site [nucleotide binding]; other site 877468013686 putative metal binding site [ion binding]; other site 877468013687 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 877468013688 active site 877468013689 catalytic site [active] 877468013690 substrate binding site [chemical binding]; other site 877468013691 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 877468013692 active site 877468013693 DNA binding site [nucleotide binding] 877468013694 catalytic site [active] 877468013695 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 877468013696 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 877468013697 putative acyl-acceptor binding pocket; other site 877468013698 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 877468013699 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 877468013700 catalytic residues [active] 877468013701 hinge region; other site 877468013702 alpha helical domain; other site 877468013703 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 877468013704 serine/threonine protein kinase; Provisional; Region: PRK11768 877468013705 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 877468013706 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 877468013707 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 877468013708 GTP binding site; other site 877468013709 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 877468013710 Walker A motif; other site 877468013711 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 877468013712 potassium transporter; Provisional; Region: PRK10750 877468013713 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 877468013714 hypothetical protein; Provisional; Region: PRK11568 877468013715 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 877468013716 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 877468013717 proline dipeptidase; Provisional; Region: PRK13607 877468013718 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 877468013719 active site 877468013720 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 877468013721 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 877468013722 substrate binding site [chemical binding]; other site 877468013723 oxyanion hole (OAH) forming residues; other site 877468013724 trimer interface [polypeptide binding]; other site 877468013725 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 877468013726 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 877468013727 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 877468013728 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 877468013729 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 877468013730 dimer interface [polypeptide binding]; other site 877468013731 active site 877468013732 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 877468013733 FMN reductase; Validated; Region: fre; PRK08051 877468013734 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 877468013735 FAD binding pocket [chemical binding]; other site 877468013736 FAD binding motif [chemical binding]; other site 877468013737 phosphate binding motif [ion binding]; other site 877468013738 beta-alpha-beta structure motif; other site 877468013739 NAD binding pocket [chemical binding]; other site 877468013740 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 877468013741 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 877468013742 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 877468013743 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 877468013744 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 877468013745 active site 877468013746 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 877468013747 sec-independent translocase; Provisional; Region: PRK01770 877468013748 sec-independent translocase; Provisional; Region: tatB; PRK00404 877468013749 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 877468013750 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 877468013751 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 877468013752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 877468013753 SCP-2 sterol transfer family; Region: SCP2; pfam02036 877468013754 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 877468013755 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 877468013756 S-adenosylmethionine binding site [chemical binding]; other site 877468013757 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 877468013758 DNA recombination protein RmuC; Provisional; Region: PRK10361 877468013759 RmuC family; Region: RmuC; pfam02646 877468013760 uridine phosphorylase; Provisional; Region: PRK11178 877468013761 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 877468013762 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 877468013763 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 877468013764 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 877468013765 FeS/SAM binding site; other site 877468013766 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 877468013767 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 877468013768 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 877468013769 THF binding site; other site 877468013770 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 877468013771 substrate binding site [chemical binding]; other site 877468013772 THF binding site; other site 877468013773 zinc-binding site [ion binding]; other site 877468013774 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 877468013775 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468013776 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 877468013777 putative dimerization interface [polypeptide binding]; other site 877468013778 putative hydrolase; Provisional; Region: PRK10976 877468013779 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 877468013780 active site 877468013781 motif I; other site 877468013782 motif II; other site 877468013783 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 877468013784 lysophospholipase L2; Provisional; Region: PRK10749 877468013785 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 877468013786 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 877468013787 threonine efflux system; Provisional; Region: PRK10229 877468013788 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 877468013789 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 877468013790 ATP binding site [chemical binding]; other site 877468013791 putative Mg++ binding site [ion binding]; other site 877468013792 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 877468013793 nucleotide binding region [chemical binding]; other site 877468013794 ATP-binding site [chemical binding]; other site 877468013795 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 877468013796 Helicase and RNase D C-terminal; Region: HRDC; smart00341 877468013797 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 877468013798 dimerization interface [polypeptide binding]; other site 877468013799 substrate binding site [chemical binding]; other site 877468013800 active site 877468013801 calcium binding site [ion binding]; other site 877468013802 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 877468013803 CoenzymeA binding site [chemical binding]; other site 877468013804 subunit interaction site [polypeptide binding]; other site 877468013805 PHB binding site; other site 877468013806 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 877468013807 EamA-like transporter family; Region: EamA; cl17759 877468013808 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 877468013809 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 877468013810 Cl binding site [ion binding]; other site 877468013811 oligomer interface [polypeptide binding]; other site 877468013812 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 877468013813 Part of AAA domain; Region: AAA_19; pfam13245 877468013814 Family description; Region: UvrD_C_2; pfam13538 877468013815 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 877468013816 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 877468013817 motif II; other site 877468013818 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 877468013819 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 877468013820 active site 877468013821 Int/Topo IB signature motif; other site 877468013822 hypothetical protein; Provisional; Region: PRK10963 877468013823 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 877468013824 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 877468013825 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 877468013826 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 877468013827 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 877468013828 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 877468013829 putative iron binding site [ion binding]; other site 877468013830 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 877468013831 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 877468013832 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 877468013833 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 877468013834 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 877468013835 domain interfaces; other site 877468013836 active site 877468013837 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 877468013838 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 877468013839 active site 877468013840 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 877468013841 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 877468013842 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 877468013843 HemY protein N-terminus; Region: HemY_N; pfam07219 877468013844 putative transport protein YifK; Provisional; Region: PRK10746 877468013845 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 877468013846 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 877468013847 putative common antigen polymerase; Provisional; Region: PRK02975 877468013848 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 877468013849 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 877468013850 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 877468013851 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 877468013852 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 877468013853 inhibitor-cofactor binding pocket; inhibition site 877468013854 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468013855 catalytic residue [active] 877468013856 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 877468013857 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 877468013858 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 877468013859 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 877468013860 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 877468013861 NAD binding site [chemical binding]; other site 877468013862 substrate binding site [chemical binding]; other site 877468013863 homodimer interface [polypeptide binding]; other site 877468013864 active site 877468013865 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 877468013866 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 877468013867 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 877468013868 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 877468013869 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 877468013870 homodimer interface [polypeptide binding]; other site 877468013871 active site 877468013872 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 877468013873 Chain length determinant protein; Region: Wzz; pfam02706 877468013874 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 877468013875 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 877468013876 Mg++ binding site [ion binding]; other site 877468013877 putative catalytic motif [active] 877468013878 substrate binding site [chemical binding]; other site 877468013879 transcription termination factor Rho; Provisional; Region: rho; PRK09376 877468013880 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 877468013881 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 877468013882 RNA binding site [nucleotide binding]; other site 877468013883 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 877468013884 multimer interface [polypeptide binding]; other site 877468013885 Walker A motif; other site 877468013886 ATP binding site [chemical binding]; other site 877468013887 Walker B motif; other site 877468013888 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 877468013889 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 877468013890 catalytic residues [active] 877468013891 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 877468013892 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 877468013893 ATP binding site [chemical binding]; other site 877468013894 Mg++ binding site [ion binding]; other site 877468013895 motif III; other site 877468013896 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 877468013897 nucleotide binding region [chemical binding]; other site 877468013898 ATP-binding site [chemical binding]; other site 877468013899 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 877468013900 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 877468013901 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 877468013902 Part of AAA domain; Region: AAA_19; pfam13245 877468013903 Family description; Region: UvrD_C_2; pfam13538 877468013904 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 877468013905 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 877468013906 ketol-acid reductoisomerase; Validated; Region: PRK05225 877468013907 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 877468013908 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 877468013909 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 877468013910 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468013911 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 877468013912 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 877468013913 putative dimerization interface [polypeptide binding]; other site 877468013914 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 877468013915 Phage-related protein [Function unknown]; Region: COG4679 877468013916 threonine dehydratase; Reviewed; Region: PRK09224 877468013917 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 877468013918 tetramer interface [polypeptide binding]; other site 877468013919 pyridoxal 5'-phosphate binding site [chemical binding]; other site 877468013920 catalytic residue [active] 877468013921 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 877468013922 putative Ile/Val binding site [chemical binding]; other site 877468013923 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 877468013924 putative Ile/Val binding site [chemical binding]; other site 877468013925 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 877468013926 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 877468013927 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 877468013928 homodimer interface [polypeptide binding]; other site 877468013929 substrate-cofactor binding pocket; other site 877468013930 catalytic residue [active] 877468013931 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 877468013932 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 877468013933 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 877468013934 PYR/PP interface [polypeptide binding]; other site 877468013935 dimer interface [polypeptide binding]; other site 877468013936 TPP binding site [chemical binding]; other site 877468013937 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 877468013938 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 877468013939 TPP-binding site [chemical binding]; other site 877468013940 dimer interface [polypeptide binding]; other site 877468013941 putative ATP-dependent protease; Provisional; Region: PRK09862 877468013942 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 877468013943 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 877468013944 Walker A motif; other site 877468013945 ATP binding site [chemical binding]; other site 877468013946 Walker B motif; other site 877468013947 arginine finger; other site 877468013948 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 877468013949 hypothetical protein; Provisional; Region: PRK11027 877468013950 transcriptional regulator HdfR; Provisional; Region: PRK03601 877468013951 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 877468013952 LysR substrate binding domain; Region: LysR_substrate; pfam03466 877468013953 dimerization interface [polypeptide binding]; other site 877468013954 Transcriptional regulators [Transcription]; Region: FadR; COG2186 877468013955 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 877468013956 DNA-binding site [nucleotide binding]; DNA binding site 877468013957 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 877468013958 putative transporter; Provisional; Region: PRK10504 877468013959 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468013960 putative substrate translocation pore; other site 877468013961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 877468013962 transcriptional repressor RbsR; Provisional; Region: PRK10423 877468013963 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 877468013964 DNA binding site [nucleotide binding] 877468013965 domain linker motif; other site 877468013966 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 877468013967 dimerization interface [polypeptide binding]; other site 877468013968 ligand binding site [chemical binding]; other site 877468013969 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 877468013970 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 877468013971 substrate binding site [chemical binding]; other site 877468013972 dimer interface [polypeptide binding]; other site 877468013973 ATP binding site [chemical binding]; other site 877468013974 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 877468013975 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 877468013976 ligand binding site [chemical binding]; other site 877468013977 dimerization interface [polypeptide binding]; other site 877468013978 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 877468013979 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 877468013980 TM-ABC transporter signature motif; other site 877468013981 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 877468013982 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 877468013983 Walker A/P-loop; other site 877468013984 ATP binding site [chemical binding]; other site 877468013985 Q-loop/lid; other site 877468013986 ABC transporter signature motif; other site 877468013987 Walker B; other site 877468013988 D-loop; other site 877468013989 H-loop/switch region; other site 877468013990 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 877468013991 D-ribose pyranase; Provisional; Region: PRK11797 877468013992 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 877468013993 potassium uptake protein; Region: kup; TIGR00794 877468013994 regulatory ATPase RavA; Provisional; Region: PRK13531 877468013995 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 877468013996 Walker A motif; other site 877468013997 ATP binding site [chemical binding]; other site 877468013998 Walker B motif; other site 877468013999 arginine finger; other site 877468014000 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 877468014001 hypothetical protein; Provisional; Region: yieM; PRK10997 877468014002 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 877468014003 metal ion-dependent adhesion site (MIDAS); other site 877468014004 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 877468014005 dimer interface [polypeptide binding]; other site 877468014006 active site 877468014007 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 877468014008 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 877468014009 putative DNA binding site [nucleotide binding]; other site 877468014010 putative Zn2+ binding site [ion binding]; other site 877468014011 AsnC family; Region: AsnC_trans_reg; pfam01037 877468014012 FMN-binding protein MioC; Provisional; Region: PRK09004