-- dump date 20140620_054251 -- class Genbank::CDS -- table cds_note -- id note YP_001586278.1 member of the SPOUT superfamily of methyltransferases YP_001586279.1 multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways YP_001586280.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate YP_001586281.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_001586282.1 COG: COG3022 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001586283.1 Psort location: mitochondrial, score: 23 YP_001586284.1 KEGG: hpa:HPAG1_0925 7.6e-63 D-alanine glycine permease K01613; COG: COG1115 Na+/alanine symporter; Psort location: plasma membrane, score: 23 YP_001586285.1 KEGG: stt:t0007 2.3e-164 talB; transaldolase B K00616; COG: COG0176 Transaldolase; Psort location: cytoplasmic, score: 23 YP_001586286.1 forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis YP_001586287.1 KEGG: dsy:DSY4088 0.0082 dmsC; putative anaerobic DMSO reductase chain C anchor subunit K00369; COG: COG1584 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001586288.1 COG: COG4735 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001586289.1 COG: NOG09752 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001586290.1 Psort location: extracellular, including cell wall, score: 9 YP_001586291.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_001586292.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_001586293.1 Psort location: endoplasmic reticulum, score: 9 YP_001586294.1 COG: COG0583 Transcriptional regulator; Psort location: nuclear, score: 23 YP_001586295.1 COG: NOG17566 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001586296.1 COG: COG3926 Putative secretion activating protein; Psort location: cytoskeletal, score: 9 YP_001586297.1 COG: COG3710 DNA-binding winged-HTH domains; Psort location: cytoplasmic, score: 23 YP_001586298.1 Psort location: endoplasmic reticulum, score: 9 YP_001586299.1 KEGG: vfi:VF1598 5.1e-46 exochitinase K01183; COG: COG3325 Chitinase; Psort location: cytoplasmic, score: 23 YP_001586300.1 COG: NOG24950 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001586301.1 Psort location: cytoplasmic, score: 23 YP_001586302.1 COG: NOG25589 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001586303.1 Psort location: cytoplasmic, score: 23 YP_001586304.1 Psort location: cytoplasmic, score: 23 YP_001586305.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001586306.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: nuclear, score: 23 YP_001586307.1 COG: COG3188 P pilus assembly protein, porin PapC; Psort location: mitochondrial, score: 23 YP_001586308.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001586309.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001586310.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001586311.1 Psort location: cytoplasmic, score: 23 YP_001586312.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: cytoplasmic, score: 23 YP_001586313.1 KEGG: mca:MCA2602 0.00037 dsbA; THIol:disulfide interchange protein DsbA K03673; COG: COG1651 Protein-disulfide isomerase; Psort location: extracellular, including cell wall, score: 9 YP_001586314.1 COG: NOG31826 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001586315.1 COG: COG3710 DNA-binding winged-HTH domains; Psort location: vesicles of secretory system, score: 9 YP_001586316.1 Psort location: endoplasmic reticulum, score: 9 YP_001586317.1 COG: NOG14106 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001586318.1 KEGG: eci:UTI89_C4527 2.5e-11 hypothetical protein K01081:K08077; COG: COG0737 5-nucleotidase/2,3-cyclic phosphodiesterase and related esterases; Psort location: nuclear, score: 23 YP_001586319.1 Psort location: nuclear, score: 23 YP_001586320.1 Psort location: mitochondrial, score: 23 YP_001586321.1 COG: NOG25516 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001586322.1 KEGG: eci:UTI89_C0020 4.2e-243 hypothetical protein K01134; COG: COG3119 Arylsulfatase A and related enzymes; Psort location: extracellular, including cell wall, score: 9 YP_001586323.1 KEGG: syg:sync_2368 8.6e-17 arylsulfatase regulator; COG: COG0641 Arylsulfatase regulator (Fe-S oxidoreductase); Psort location: cytoplasmic, score: 23 YP_001586324.1 COG: NOG26060 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001586325.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH YP_001586326.1 Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC YP_001586327.1 KEGG: sso:SSO3022 2.6e-94 xylS; alpha-xylosidase K01238; COG: COG1501 Alpha-glucosidases, family 31 of glycosyl hydrolases; Psort location: cytoplasmic, score: 23 YP_001586328.1 KEGG: eci:UTI89_C4210 6.4e-50 yicJ; hypothetical symporter YicJ K03292; COG: COG2211 Na+/melibiose symporter and related transporters; Psort location: plasma membrane, score: 23 YP_001586329.1 COG: COG0268 Ribosomal protein S20; Psort location: nuclear, score: 23 YP_001586330.1 COG: NOG13907 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001586331.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities YP_001586332.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme YP_001586333.1 KEGG: spt:SPA0048 1.0e-76 lspA; lipoprotein signal peptidase K03101; COG: COG0597 Lipoprotein signal peptidase; Psort location: endoplasmic reticulum, score: 9 YP_001586334.1 KEGG: sec:SC0042 2.1e-74 slpA; FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase) K03774; COG: COG1047 FKBP-type peptidyl-prolyl cis-trans isomerases 2; Psort location: extracellular, including cell wall, score: 9 YP_001586335.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway YP_001586336.1 Psort location: cytoplasmic, score: 23 YP_001586337.1 COG: NOG26437 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001586338.1 catalyzes the hydrolysis of both purine and pyrimidine ribonucleosides YP_001586339.1 KEGG: bcz:BCZK0490 2.4e-20 response regulator K02475; COG: COG4565 Response regulator of citrate/malate metabolism; Psort location: cytoplasmic, score: 23 YP_001586340.1 KEGG: sec:SC0047 3.2e-293 citA; putative transcription regulator, histidine kinase for citrate; COG: COG3290 Signal transduction histidine kinase regulating citrate/malate metabolism; Psort location: endoplasmic reticulum, score: 9 YP_001586341.1 KEGG: sec:SC0048 4.8e-219 oadB; putative oxalacetate decarboxylase, subunit beta K01572; COG: COG1883 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit; Psort location: plasma membrane, score: 23 YP_001586342.1 catalyzes the formation of pyruvate from oxaloacetate YP_001586343.1 catalyzes the decarboxylation of oxaloacetate to form pyruvate and carbon dioxide YP_001586344.1 COG: COG3493 Na+/citrate symporter; Psort location: plasma membrane, score: 23 YP_001586345.1 Psort location: mitochondrial, score: 23 YP_001586346.1 KEGG: stm:STM0058 1.4e-182 citC2; putative citrate lyase synthetase K01910; COG: COG3053 Citrate lyase synthetase; Psort location: cytoplasmic, score: 23 YP_001586347.1 acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate YP_001586348.1 KEGG: stm:STM0060 3.8e-148 citE2; putative citrate lyase beta chain (acyl lyase subunit) K01644; COG: COG2301 Citrate lyase beta subunit; Psort location: extracellular, including cell wall, score: 9 YP_001586349.1 KEGG: stm:STM0061 1.2e-268 citF2; putativ bifunctional citrate lyase alpha chain/citrate-ACP transferase K01643; COG: COG3051 Citrate lyase, alpha subunit; Psort location: cytoplasmic, score: 23 YP_001586350.1 KEGG: sty:STY0071 1.0e-97 citX2; citx protein; COG: COG3697 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase); Psort location: cytoplasmic, score: 23 YP_001586351.1 KEGG: sec:SC0057 5.3e-158 citG2; putative modifier of citrate lyase protein K05966; COG: COG1767 Triphosphoribosyl-dephospho-CoA synthetase; Psort location: cytoplasmic, score: 23 YP_001586352.1 Psort location: mitochondrial, score: 23 YP_001586353.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_001586354.1 Psort location: cytoplasmic, score: 23 YP_001586355.1 Psort location: endoplasmic reticulum, score: 9 YP_001586356.1 Psort location: nuclear, score: 23 YP_001586357.1 Psort location: mitochondrial, score: 23 YP_001586358.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_001586359.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity YP_001586360.1 regulator of carnitine metabolism; induces the caiTABCDE and fixABCX operons YP_001586361.1 involved in the synthesis of a cofactor required for carnitine dehydratase and carnitine racemase activities YP_001586362.1 catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA YP_001586363.1 KEGG: stt:t0072 1.7e-280 caiC; probable crotonobetaine/carnitine-CoA ligase K02182; COG: COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II; Psort location: cytoplasmic, score: 23 YP_001586364.1 catalyzes formation of L-carnitinyl-CoA by transfering the CoA moiety from gamma-butyrobetainyl-CoA, also catalyzes the formation of crotonobetainyl-CoA by transfer of CoA from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine YP_001586365.1 Psort location: mitochondrial, score: 23 YP_001586366.1 catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA YP_001586367.1 catalyzes the exchange of L-carnitine for gamma-butyrobetaine in carnitine metabolism YP_001586368.1 Psort location: nuclear, score: 23 YP_001586369.1 Psort location: endoplasmic reticulum, score: 9 YP_001586370.1 required for anaerobic carnitine reduction, may act to transfer electrons to crotonobetaine reductase YP_001586371.1 involved in electron transfer during carnitine metabolism YP_001586372.1 FAD/NAD(P)-binding domain; possibly part of an electron transfer system required for anaerobic carnitine reduction YP_001586373.1 KEGG: hma:rrnAC0094 3.9e-06 ydiS; flavoprotein probably electron transport K00313; COG: COG2440 Ferredoxin-like protein; Psort location: cytoplasmic, score: 23 YP_001586374.1 KEGG: cal:orf19.4384 5.5e-16 HXT10; fructose symporter K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001586375.1 KEGG: efa:EF0685 0.0030 rotamase family protein K07533; COG: NOG17119 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001586376.1 Psort location: cytoplasmic, score: 23 YP_001586377.1 COG: NOG27675 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001586378.1 Psort location: mitochondrial, score: 23 YP_001586379.1 COG: NOG31170 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001586380.1 COG: NOG34507 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001586381.1 KEGG: reh:H16_B0315 3.1e-137 arylsulfatase K01130; COG: COG3119 Arylsulfatase A and related enzymes; Psort location: cytoplasmic, score: 23 YP_001586382.1 Psort location: nuclear, score: 23 YP_001586383.1 Psort location: nuclear, score: 23 YP_001586384.1 Psort location: nuclear, score: 23 YP_001586385.1 Required for full activity of KefC, a potassium-proton antiporter YP_001586386.1 transport system that facilitates potassium-efflux YP_001586387.1 Psort location: mitochondrial, score: 23 YP_001586388.1 catalyzes the reduction of dihydrofolate to tetrahydrofolate YP_001586389.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP YP_001586390.1 protein associated with Co2+ and Mg2+ efflux YP_001586391.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_001586392.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate) YP_001586393.1 Chaperone involved in the folding of extracytoplasmic proteins, especially OmpA, OmpF and LamB YP_001586394.1 determines N-hexane tolerance and is involved in outer membrane permeability YP_001586395.1 Psort location: mitochondrial, score: 23 YP_001586396.1 functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system YP_001586397.1 catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs YP_001586398.1 transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA YP_001586399.1 Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C YP_001586400.1 Psort location: mitochondrial, score: 23 YP_001586401.1 COG: COG1434 Uncharacterized conserved protein; Psort location: mitochondrial, score: 23 YP_001586402.1 Psort location: cytoplasmic, score: 23 YP_001586403.1 COG: NOG28502 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001586404.2 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source YP_001586405.1 catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism YP_001586406.1 catalyzes the phosphorylation of ribulose to ribulose 5-phosphate YP_001586407.1 positive and negative regulator; regulates the araBAD and araFGH operons and other genes involved in the transport and catabolism of L-arabinose YP_001586408.1 KEGG: lsl:LSL_1322 0.0087 alkaline phosphatase K01077; COG: COG0586 Uncharacterized membrane-associated protein; Psort location: plasma membrane, score: 23 YP_001586409.1 with TbpA and ThiP is part of the thiamine and TPP transport system YP_001586410.1 permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine YP_001586411.1 part of the thiamine and TPP transport system tbpA-thiPQ YP_001586412.1 activates sgrS under glucose-phosphate stress conditions YP_001586413.1 Psort location: mitochondrial, score: 23 YP_001586414.1 Psort location: nuclear, score: 23 YP_001586415.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D YP_001586416.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_001586417.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis YP_001586418.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis YP_001586419.1 Psort location: mitochondrial, score: 23 YP_001586420.1 Psort location: mitochondrial, score: 23 YP_001586421.1 activator for leuABCD operon; member of LysR family of transcriptional activators YP_001586422.1 catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive YP_001586423.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit YP_001586424.1 Psort location: cytoplasmic, score: 23 YP_001586425.1 binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism YP_001586426.1 Psort location: cytoplasmic, score: 23 YP_001586427.1 Psort location: cytoplasmic, score: 23 YP_001586428.1 MraZ; UPF0040; crystal structure shows similarity to AbrB YP_001586429.1 KEGG: stm:STM0120 6.3e-162 yabC; putative S-adenosyl meTHIonine adenyltransferase K03438; COG: COG0275 Predicted S-adenosylmeTHIonine-dependent methyltransferase involved in cell envelope biogenesis; Psort location: cytoplasmic, score: 23 YP_001586430.1 COG: COG3116 Cell division protein; Psort location: cytoplasmic, score: 23 YP_001586431.1 KEGG: stt:t0126 0. ftsI; penicillin-binding protein 3 precursor K03587; COG: COG0768 Cell division protein FtsI/penicillin-binding protein 2; Psort location: endoplasmic reticulum, score: 23 YP_001586432.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate YP_001586433.1 KEGG: spt:SPA0126 4.2e-236 murF; UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diami nopimelate--D-alan alanyl ligase K01929; COG: COG0770 UDP-N-acetylmuramyl pentapeptide synthase; Psort location: cytoplasmic, score: 23 YP_001586434.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_001586435.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_001586436.1 integral membrane protein involved in stabilizing FstZ ring during cell division YP_001586437.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_001586438.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_001586439.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_001586440.1 involved in septum formation YP_001586441.1 ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane YP_001586442.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_001586443.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis YP_001586444.1 secM translational pause allows for the initiation of secA translation YP_001586445.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_001586446.1 KEGG: stt:t0141 5.4e-69 mutT; 7,8-dihydro-8-oxoguanine-triphosphatase K03574; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: cytoplasmic, score: 23 YP_001586447.1 COG: COG0583 Transcriptional regulator; Psort location: mitochondrial, score: 23 YP_001586448.1 KEGG: gbe:GbCGDNIH1_1027 3.4e-05 ribonuclease G; COG: COG3024 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001586449.1 COG: COG4582 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001586450.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis YP_001586451.1 catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate YP_001586452.1 COG: COG1459 Type II secretory pathway, component PulF; Psort location: endoplasmic reticulum, score: 9 YP_001586453.1 KEGG: pen:PSEEN2333 1.2e-80 xcpR-2; type II secretion pathway protein E K01509; COG: COG2804 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB; Psort location: cytoplasmic, score: 23 YP_001586454.1 COG: COG4969 Tfp pilus assembly protein, major pilin PilA; Psort location: mitochondrial, score: 23 YP_001586455.1 Psort location: mitochondrial, score: 23 YP_001586456.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide YP_001586457.1 KEGG: eci:UTI89_C0118 8.3e-89 ampD; AmpD protein K03806; COG: COG3023 Negative regulator of beta-lactamase expression; Psort location: cytoplasmic, score: 23 YP_001586458.1 involved in regulation of beta-lactamase; putative signaling protein YP_001586459.1 KEGG: sde:Sde_0777 2.6e-101 ribosomal protein L11 methyltransferase K01209; COG: COG3940 Predicted beta-xylosidase; Psort location: cytoplasmic, score: 23 YP_001586460.1 KEGG: eci:UTI89_C4210 1.3e-113 yicJ; hypothetical symporter YicJ K03292; COG: COG2211 Na+/melibiose symporter and related transporters; Psort location: plasma membrane, score: 23 YP_001586461.1 KEGG: eci:UTI89_C0120 3.0e-226 aroP; aromatic amino acid transport protein AroP K03293; COG: COG1113 Gamma-aminobutyrate permease and related permeases; Psort location: plasma membrane, score: 23 YP_001586462.1 Psort location: mitochondrial, score: 23 YP_001586463.1 activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex YP_001586464.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC YP_001586465.1 E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains YP_001586466.1 Psort location: mitochondrial, score: 23 YP_001586467.1 E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_001586468.1 Psort location: cytoplasmic, score: 23 YP_001586469.1 KEGG: hne:HNE_1624 0.0086 sodA; superoxide dismutase, Mn K00518; COG: NOG32314 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001586470.1 COG: NOG09806 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001586471.1 KEGG: ddi:DDB0231210 0.0042 putative CDC7 family protein kinase K02214; COG: NOG06276 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001586472.1 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate YP_001586473.1 COG: COG3112 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001586474.1 Psort location: nuclear, score: 23 YP_001586475.1 transports degraded pectin products into the bacterial cell YP_001586476.1 KEGG: art:Arth_1035 3.3e-16 4-hydroxythreonine-4-phosphate dehydrogenase K00097; COG: COG3395 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001586477.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate) YP_001586478.1 COG: COG1349 Transcriptional regulators of sugar metabolism; Psort location: cytoplasmic, score: 23 YP_001586479.1 S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine YP_001586480.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine YP_001586481.1 COG: NOG09835 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001586482.1 laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification YP_001586483.1 KEGG: stm:STM0169 0. gcd; glucose dehydrogenase K00117; COG: COG4993 Glucose dehydrogenase; Psort location: plasma membrane, score: 23 YP_001586484.1 KEGG: sec:SC0170 4.6e-95 hpt; hypoxanTHIne phosphoribosyltransferase K00760; COG: COG0634 HypoxanTHIne-guanine phosphoribosyltransferase; Psort location: cytoplasmic, score: 23 YP_001586485.1 catalyzes the interconversion of bicarbonate and carbon dioxide YP_001586486.1 KEGG: pen:PSEEN1596 5.3e-94 ABC transporter, ATP-binding protein; COG: COG1131 ABC-type multidrug transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001586487.1 COG: COG0842 ABC-type multidrug transport system, permease component; Psort location: plasma membrane, score: 23 YP_001586488.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001586489.1 COG: COG3188 P pilus assembly protein, porin PapC; Psort location: nuclear, score: 23 YP_001586490.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: extracellular, including cell wall, score: 9 YP_001586491.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001586492.1 Psort location: mitochondrial, score: 23 YP_001586493.1 Psort location: mitochondrial, score: 23 YP_001586494.1 Psort location: cytoplasmic, score: 23 YP_001586495.1 KEGG: sty:STY0196 3.9e-75 yadI; putative PTS system IIA component K02821; COG: COG2893 Phosphotransferase system, mannose/fructose-specific component IIA; Psort location: cytoplasmic, score: 23 YP_001586496.1 KEGG: azo:azo2324 5.5e-21 putative polysaccharide deacetylase; COG: COG0726 Predicted xylanase/chitin deacetylase; Psort location: extracellular, including cell wall, score: 9 YP_001586497.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5) YP_001586498.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine YP_001586499.1 Psort location: mitochondrial, score: 23 YP_001586500.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate YP_001586501.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: nuclear, score: 23 YP_001586502.1 COG: NOG18510 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001586503.1 COG: NOG14108 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001586504.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001586505.1 similar to the fimbrial usher protein PapC YP_001586506.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: extracellular, including cell wall, score: 9 YP_001586507.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001586508.1 Psort location: mitochondrial, score: 23 YP_001586509.1 catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP YP_001586510.1 Polymerase that creates the 3' poly(A) tail found in some mRNA's YP_001586511.1 this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu YP_001586512.1 COG: COG1734 DnaK suppressor protein; Psort location: nuclear, score: 23 YP_001586513.1 Regulatory factor involved in maltose metabolism YP_001586514.1 KEGG: stm:STM0188 8.7e-94 ligT; 2'-5' RNA ligase K01975; COG: COG1514 2-5 RNA ligase; Psort location: cytoplasmic, score: 23 YP_001586515.1 similar in sequence to the ATP-dependent RNA helicase HrpA YP_001586516.1 Psort location: cytoplasmic, score: 23 YP_001586517.1 bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell YP_001586518.1 Psort location: nuclear, score: 23 YP_001586519.1 Psort location: nuclear, score: 23 YP_001586520.1 involved with the transport of ferrichrome across the outer membrane; binds the ferrichrome-iron ligand and interacts with the TonB protein YP_001586521.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter YP_001586522.1 Part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; binds to all hydroxamate siderophores YP_001586523.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome YP_001586524.1 Psort location: cytoplasmic, score: 23 YP_001586525.1 Psort location: cytoplasmic, score: 23 YP_001586526.1 Psort location: cytoplasmic, score: 23 YP_001586527.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 23 YP_001586528.1 COG: COG3188 P pilus assembly protein, porin PapC; Psort location: endoplasmic reticulum, score: 9 YP_001586529.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: extracellular, including cell wall, score: 9 YP_001586530.1 COG: NOG13897 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001586531.1 COG: NOG09769 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001586532.1 COG: NOG23107 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001586533.1 COG: NOG06206 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001586534.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway YP_001586535.1 Psort location: cytoplasmic, score: 23 YP_001586536.1 Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation YP_001586537.1 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors YP_001586538.1 COG: COG2860 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001586539.1 solute binding component of the vitamin B12 transport system BtuCDF YP_001586540.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine YP_001586541.1 forms a homotetramer; requires magnesium for activity; catalyzes the hydrolysis of dGTP to form deoxyguanosine and triphosphate YP_001586542.1 protease Do; required at high temperature; degrades damaged proteins YP_001586543.1 regulates the expression of the operons for the enzymes involved in galactarate, glucarate and glycerate utilization YP_001586544.1 COG: NOG09673 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001586545.1 Psort location: mitochondrial, score: 23 YP_001586546.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001586547.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway YP_001586548.1 catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein YP_001586549.1 Psort location: cytoplasmic, score: 23 YP_001586550.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn YP_001586551.1 Psort location: cytoplasmic, score: 23 YP_001586552.2 COG: COG0052 Ribosomal protein S2; Psort location: cytoplasmic, score: 23 YP_001586553.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_001586554.1 Catalyzes the phosphorylation of UMP to UDP YP_001586555.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_001586556.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate YP_001586557.1 Psort location: mitochondrial, score: 23 YP_001586558.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate YP_001586559.1 catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate YP_001586560.1 catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response YP_001586561.1 part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins YP_001586562.1 COG: COG2825 Outer membrane protein; Psort location: extracellular, including cell wall, score: 9 YP_001586563.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis YP_001586564.1 Psort location: mitochondrial, score: 23 YP_001586565.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP YP_001586566.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis YP_001586567.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM YP_001586568.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_001586569.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase YP_001586570.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein YP_001586571.1 Psort location: nuclear, score: 23 YP_001586572.1 KEGG: bam:Bamb_1428 8.2e-31 chitinase K01183; COG: COG3979 Uncharacterized protein contain chitin-binding domain type 3; Psort location: extracellular, including cell wall, score: 9 YP_001586573.1 KEGG: stm:STM0234 0. ldcC; lysine decarboxylase 2 K01582; COG: COG1982 Arginine/lysine/orniTHIne decarboxylases; Psort location: cytoplasmic, score: 23 YP_001586574.1 KEGG: sec:SC0235 1.4e-68 yaeR; putative lactoylglutaTHIone lyase K01759; COG: COG0346 LactoylglutaTHIone lyase and related lyases; Psort location: cytoplasmic, score: 23 YP_001586575.1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU; ATP-dependent; responsible for modifying the wobble-base of the CAU anticodon of tRNAIle such that it exhibits proper recognition of the AUA codon rather than the AUG codon and is in turn properly recognized by isoleucyl-tRNA synthetase YP_001586576.1 KEGG: stm:STM4281 0.00029 nrfE; putative methylase K04016; Psort location: nuclear, score: 23 YP_001586577.1 COG: COG4568 Transcriptional antiterminator; Psort location: cytoplasmic, score: 23 YP_001586578.1 COG: NOG13866 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001586579.1 KEGG: bpm:BURPS1710b_0319 2.5e-41 YaeQ protein K00356; COG: COG4681 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001586580.1 KEGG: reh:H16_A3611 1.8e-31 pth2; peptidyl-tRNA hydrolase; COG: COG1186 Protein chain release factor B; Psort location: nuclear, score: 23 YP_001586581.1 COG: COG3015 Uncharacterized lipoprotein NlpE involved in copper resistance; Psort location: mitochondrial, score: 23 YP_001586582.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_001586583.1 KEGG: eci:UTI89_C0211 1.7e-111 yaeB; hypothetical protein YaeB; COG: COG1720 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001586584.1 COG: NOG09836 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001586585.1 COG: COG1464 ABC-type metal ion transport system, periplasmic component/surface antigen; Psort location: extracellular, including cell wall, score: 9 YP_001586586.1 part of the MetNIQ methionine uptake system YP_001586587.1 part of the metNIQ transport system for methionine YP_001586588.1 Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate YP_001586589.1 Psort location: cytoplasmic, score: 23 YP_001586590.1 COG: NOG09993 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001586591.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001586592.1 COG: COG5544 Predicted periplasmic lipoprotein; Psort location: cytoplasmic, score: 23 YP_001586593.1 catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome YP_001586594.1 KEGG: eci:UTI89_C2907 0. yfiQ; hypothetical protein YfiQ K09181; COG: COG1042 Acyl-CoA synthetase (NDP forming); Psort location: cytoplasmic, score: 23 YP_001586595.1 COG: COG3148 Uncharacterized conserved protein; Psort location: mitochondrial, score: 23 YP_001586596.1 KEGG: stm:STM2649 1.7e-74 trxC; THIoredoxin 2, redox factor K03672; COG: COG0526 Thiol-disulfide isomerase and THIoredoxins; Psort location: cytoplasmic, score: 23 YP_001586597.1 KEGG: stt:t0262 1.3e-186 yfiF; putative RNA methyltransferase K03214; COG: COG0566 rRNA methylases; Psort location: cytoplasmic, score: 23 YP_001586598.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine YP_001586599.1 stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit YP_001586600.1 COG: COG1280 Putative threonine efflux protein; Psort location: endoplasmic reticulum, score: 9 YP_001586601.1 Psort location: mitochondrial, score: 23 YP_001586602.1 KEGG: shn:Shewana3_3435 6.1e-06 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001586603.1 facilitates an early step in the assembly of the 50S subunit of the ribosome YP_001586604.1 KEGG: eci:UTI89_C2897 4.6e-111 yfiC; hypothetical protein YfiC K00599; COG: COG4123 Predicted O-methyltransferase; Psort location: cytoplasmic, score: 23 YP_001586605.1 catalyzes the formation of oxaloacetate from L-aspartate YP_001586606.1 Psort location: cytoplasmic, score: 23 YP_001586607.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response YP_001586608.1 COG: COG3073 Negative regulator of sigma E activity; Psort location: nuclear, score: 23 YP_001586609.1 periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP YP_001586610.1 involved in the reduction of the SoxR iron-sulfur cluster YP_001586611.1 Psort location: nuclear, score: 23 YP_001586612.1 Psort location: cytoplasmic, score: 23 YP_001586613.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_001586614.1 catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins YP_001586615.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_001586616.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA YP_001586617.1 involved in the de novo synthesis of pyridoxine (Vitamin B6) YP_001586618.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids YP_001586619.1 KEGG: bte:BTH_II0708 0.0043 fdxH; formate dehydrogenase, beta subunit K00124; COG: COG1145 Ferredoxin; Psort location: cytoplasmic, score: 23 YP_001586620.1 KEGG: shn:Shewana3_3435 1.0e-19 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: vesicles of secretory system, score: 23 YP_001586621.1 KEGG: dre:30298 2.6e-07 jak2b; Janus kinase 2b K04447; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001586622.1 KEGG: stt:t0284 1.2e-158 putative oxidoreductase K00077; COG: COG1893 Ketopantoate reductase; Psort location: cytoplasmic, score: 23 YP_001586623.1 KEGG: bte:BTH_I1550 3.9e-24 glucokinase/transcriptional regulator, RpiR family, fusion K00845; COG: COG1737 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001586624.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway YP_001586625.1 KEGG: stm:STM2570 7.8e-235 PTS system, sucrose-specific IIBC component, putative K02809:K02810; COG: COG1264 Phosphotransferase system IIB components; Psort location: plasma membrane, score: 23 YP_001586626.1 COG: COG0560 Phosphoserine phosphatase; Psort location: cytoplasmic, score: 23 YP_001586627.1 KEGG: stt:t0289 1.2e-89 yfhC; hypothetical protein K01500; COG: COG0590 Cytosine/adenosine deaminases; Psort location: cytoplasmic, score: 23 YP_001586628.1 YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function YP_001586629.1 Psort location: mitochondrial, score: 23 YP_001586630.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_001586631.1 Psort location: cytoplasmic, score: 23 YP_001586632.1 KEGG: sec:SC2559 2.6e-250 yfhK; putative sensory kinase in regulatory system K07711; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 9 YP_001586633.1 COG: NOG06210 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001586634.1 KEGG: eci:UTI89_C2502 9.1e-83 atoC; acetoacetate metabolism regulatory protein AtoC K07714; COG: COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains; Psort location: cytoplasmic, score: 23 YP_001586635.1 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA YP_001586636.1 COG: COG3104 Dipeptide/tripeptide permease; Psort location: plasma membrane, score: 23 YP_001586637.1 KEGG: stm:STM2559 0. cadA; lysine decarboxylase 1 K01582; COG: COG1982 Arginine/lysine/orniTHIne decarboxylases; Psort location: cytoplasmic, score: 23 YP_001586638.1 antiporter protein responsible for lysine import and cadaverine export; member of the lysine-dependent acid resistance system 4 (AR4); inner membrane protein YP_001586639.1 regulates the cadBA operon YP_001586640.1 Psort location: mitochondrial, score: 23 YP_001586641.1 flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine YP_001586642.1 Psort location: cytoplasmic, score: 23 YP_001586643.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_001586644.1 Psort location: nuclear, score: 23 YP_001586645.1 putative transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters YP_001586646.1 KEGG: spz:M5005_Spy_1664 0.0023 PTS system, mannitol (cryptic)-specific IIA component K00890; COG: COG3711 Transcriptional antiterminator; Psort location: mitochondrial, score: 23 YP_001586647.1 COG: COG3683 ABC-type uncharacterized transport system, periplasmic component; Psort location: golgi, score: 9 YP_001586648.1 KEGG: mlo:mll9630 0.0013 cytochrome c oxidase subunit I K02274; COG: COG2215 ABC-type uncharacterized transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001586649.1 KEGG: stt:t0306 4.0e-183 asrC; anaerobic sulfite reductase subunit C K00385; COG: COG2221 Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits; Psort location: cytoplasmic, score: 23 YP_001586650.1 with AsrAC catalyzes the reduction of sulfite to hydrogen sulfide YP_001586651.1 KEGG: cno:NT01CX_0257 1.6e-78 anaerobic sulfite reductase subunit A K00437; COG: COG1145 Ferredoxin; Psort location: nuclear, score: 23 YP_001586652.1 KEGG: sfx:S2753 5.5e-108 putative enzyme; COG: COG1073 Hydrolases of the alpha/beta superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001586653.1 KEGG: sec:SC2540 6.9e-140 suhB; inositol monophosphatase K01092; COG: COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family; Psort location: cytoplasmic, score: 23 YP_001586654.1 Psort location: nuclear, score: 23 YP_001586655.1 KEGG: stm:STM2545 2.5e-126 putative rRNA methylase K02533; COG: COG0565 rRNA methylase; Psort location: cytoplasmic, score: 23 YP_001586656.1 regulates the expression of the iscRSUA operon YP_001586657.1 Psort location: nuclear, score: 23 YP_001586658.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis YP_001586659.1 KEGG: rxy:Rxyl_1354 9.8e-16 tRNA (5-methylaminomethyl-2-THIouridylate)-methyltransferase K00566; COG: COG0822 NifU homolog involved in Fe-S cluster formation; Psort location: cytoplasmic, score: 23 YP_001586660.1 forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein YP_001586661.1 J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins YP_001586662.1 involved in the maturation of iron-sulfur cluster-containing proteins YP_001586663.1 KEGG: eci:UTI89_C2847 2.2e-56 fdx; ferredoxin, 2Fe-2S K04755; COG: COG0633 Ferredoxin; Psort location: cytoplasmic, score: 23 YP_001586664.1 COG: COG2975 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001586665.1 Psort location: extracellular, including cell wall, score: 9 YP_001586666.1 catalyzes the removal of an N-terminal amino acid from a peptide or arylamide YP_001586667.1 enhances serine sensitivity caused by inhibition of homoserine dehydrogenase I YP_001586668.1 Psort location: nuclear, score: 23 YP_001586669.1 COG: NOG26904 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001586670.1 Psort location: nuclear, score: 23 YP_001586671.1 Psort location: endoplasmic reticulum, score: 9 YP_001586672.1 catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds YP_001586673.1 COG: COG2373 Large extracellular alpha-helical protein; Psort location: cytoplasmic, score: 23 YP_001586674.1 penicillin-insensitive transglycosylase/transpeptidase YP_001586675.1 KEGG: dsy:DSY0357 1.5e-238 dmsA; putative anaerobic DMSO reductase chain A precursor K00369; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: cytoplasmic, score: 23 YP_001586676.1 KEGG: dsy:DSY0356 9.7e-63 dmsB; putative anaerobic DMSO reductase chain B iron-sulfur subunit K00369; COG: COG0437 Fe-S-cluster-containing hydrogenase components 1; Psort location: nuclear, score: 23 YP_001586677.1 KEGG: dsy:DSY1249 6.6e-32 dmsC; putative anaerobic DMSO reductase chain C anchor subunit K00369; COG: COG3302 DMSO reductase anchor subunit; Psort location: plasma membrane, score: 23 YP_001586678.1 KEGG: mja:MJ0264 3.0e-10 carbon monoxide dehydrogenase, iron sulfur subunit CooF-1 K00196; COG: COG1145 Ferredoxin; Psort location: cytoplasmic, score: 23 YP_001586679.1 Psort location: cytoplasmic, score: 23 YP_001586680.1 KEGG: sty:STY2771 1.8e-52 ndk; nucleoside diphosphate kinase (ndk) K00940; COG: COG0105 Nucleoside diphosphate kinase; Psort location: cytoplasmic, score: 23 YP_001586681.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance YP_001586682.1 Psort location: cytoplasmic, score: 23 YP_001586683.1 KEGG: bca:BCE_1379 0.00077 odhB; dihydrolipoamide acetyltransferase K00658; COG: COG1426 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001586684.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis YP_001586685.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_001586686.1 COG: COG2976 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001586687.1 with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis YP_001586688.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_001586689.1 Psort location: mitochondrial, score: 23 YP_001586690.1 KEGG: aha:AHA_1764 5.4e-14 ubiquitin ligase sinat5 K01932; COG: NOG17950 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001586691.1 Psort location: mitochondrial, score: 23 YP_001586692.1 Psort location: nuclear, score: 23 YP_001586693.1 COG: NOG08628 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001586694.1 COG: NOG20953 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001586695.1 COG: NOG25158 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001586696.1 KEGG: chu:CHU_3439 1.4e-05 CHU large protein; possible glycerol kinase-related K01238; COG: NOG25158 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001586697.1 Psort location: cytoplasmic, score: 23 YP_001586698.1 KEGG: bme:BMEII0148 1.6e-77 extracellular serine protease; COG: COG3210 Large exoproteins involved in heme utilization or adhesion; Psort location: mitochondrial, score: 23 YP_001586699.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_001586700.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate YP_001586701.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_001586702.1 COG: COG2801 Transposase and inactivated derivatives; Psort location: nuclear, score: 23 YP_001586703.1 Psort location: cytoplasmic, score: 23 YP_001586704.1 COG: NOG13900 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001586705.1 COG: NOG31354 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001586706.1 COG: NOG34782 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001586707.1 KEGG: shn:Shewana3_3829 5.3e-23 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) K01745; COG: COG2199 FOG: GGDEF domain; Psort location: endoplasmic reticulum, score: 9 YP_001586708.1 KEGG: sty:STY2743 2.0e-275 ppx; exopolyphosphatase K01514; COG: COG0248 Exopolyphosphatase; Psort location: endoplasmic reticulum, score: 9 YP_001586709.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate YP_001586710.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate YP_001586711.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_001586712.1 Psort location: mitochondrial, score: 23 YP_001586713.1 Psort location: cytoplasmic, score: 23 YP_001586714.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate YP_001586715.1 KEGG: bcz:BCZK0244 1.3e-07 guanine-hypoxanTHIne permease; xanTHIne/uracil permease family protein K06901; COG: COG2233 XanTHIne/uracil permeases; Psort location: plasma membrane, score: 23 YP_001586716.1 controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP YP_001586717.1 KEGG: mca:MCA2520 5.8e-33 arsC; arsenate reductase; COG: COG1393 Arsenate reductase and related proteins, glutaredoxin family; Psort location: mitochondrial, score: 23 YP_001586718.1 KEGG: eci:UTI89_C2810 8.4e-238 yfgC; hypothetical protein YfgC precursor; COG: COG4783 Putative Zn-dependent protease, contains TPR repeats; Psort location: extracellular, including cell wall, score: 9 YP_001586719.1 KEGG: tbd:Tbd_2668 7.0e-28 phosphoribosylaminoimidazole-succinocarboxamide (SAICAR) synthetase K01923; COG: COG0628 Predicted permease; Psort location: plasma membrane, score: 23 YP_001586720.1 Psort location: cytoplasmic, score: 23 YP_001586721.1 KEGG: shn:Shewana3_2682 6.1e-61 transcriptional regulator, CdaR K01694; COG: COG3835 Sugar diacid utilization regulator; Psort location: mitochondrial, score: 23 YP_001586722.1 KEGG: eci:UTI89_C3106 7.8e-19 ygbN; hypothetical permease YgbN K03299; COG: COG2610 H+/gluconate symporter and related permeases; Psort location: plasma membrane, score: 23 YP_001586723.1 KEGG: spt:SPA0377 2.8e-198 putative glycerate kinase K00865; COG: COG1929 Glycerate kinase; Psort location: cytoplasmic, score: 23 YP_001586724.1 bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine YP_001586725.1 negative transcriptional regulator of the gcvTHP operon YP_001586726.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_001586727.1 COG: COG3317 Uncharacterized lipoprotein; Psort location: golgi, score: 9 YP_001586728.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_001586729.1 KEGG: eci:UTI89_C2802 1.5e-146 ypfJ; hypothetical protein; COG: COG2321 Predicted metalloprotease; Psort location: mitochondrial, score: 23 YP_001586730.1 COG: COG1444 Predicted P-loop ATPase fused to an acetyltransferase; Psort location: cytoplasmic, score: 23 YP_001586731.1 COG: NOG13899 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001586732.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. YP_001586733.1 KEGG: eci:UTI89_C2797 5.8e-49 yffB; conserved THIoredoxin-like protein; COG: COG1393 Arsenate reductase and related proteins, glutaredoxin family; Psort location: cytoplasmic, score: 23 YP_001586734.1 Psort location: cytoplasmic, score: 23 YP_001586735.1 KEGG: eci:UTI89_C2351 5.3e-110 yegO; hypothetical protein YegO K07789; COG: COG0841 Cation/multidrug efflux pump; Psort location: plasma membrane, score: 23 YP_001586736.1 KEGG: stm:STM2480 1.4e-297 narQ; sensory histidine kinase in two-component regulatory system with NarP ( NarL) K07674; COG: COG3850 Signal transduction histidine kinase, nitrate/nitrite-specific; Psort location: endoplasmic reticulum, score: 9 YP_001586737.1 unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic) YP_001586738.1 Psort location: nuclear, score: 23 YP_001586739.1 Psort location: cytoplasmic, score: 23 YP_001586740.1 KEGG: oih:OB0667 3.5e-49 beta-lactamase K01467; COG: COG1680 Beta-lactamase class C and other penicillin binding proteins; Psort location: extracellular, including cell wall, score: 9 YP_001586741.1 KEGG: eci:UTI89_C2793 1.7e-88 yffH; hypothetical protein YffH K01515; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: cytoplasmic, score: 23 YP_001586742.1 COG: NOG06758 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001586743.1 COG: NOG31287 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001586744.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_001586745.1 KEGG: sty:STY2710 3.3e-165 talA; transaldolase A K00616; COG: COG0176 Transaldolase; Psort location: cytoplasmic, score: 23 YP_001586746.1 Psort location: cytoplasmic, score: 23 YP_001586747.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate YP_001586748.1 KEGG: sat:SYN_00303 0.0048 hydroxyethylTHIazole kinase K00878; COG: COG4810 Ethanolamine utilization protein; Psort location: cytoplasmic, score: 23 YP_001586749.1 KEGG: eci:UTI89_C2785 3.7e-70 eutP; ethanolamine utilization protein EutP K04029; COG: COG4917 Ethanolamine utilization protein; Psort location: cytoplasmic, score: 23 YP_001586750.1 COG: COG4766 Ethanolamine utilization protein; Psort location: cytoplasmic, score: 23 YP_001586751.1 KEGG: stm:STM2467 1.3e-140 eutT; putative cobalamin adenosyltransferase, ethanolamine utilization K04032; COG: COG4812 Ethanolamine utilization cobalamin adenosyltransferase; Psort location: cytoplasmic, score: 23 YP_001586752.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta YP_001586753.1 COG: COG4577 Carbon dioxide concentrating mechanism/carboxysome shell protein; Psort location: cytoplasmic, score: 23 YP_001586754.1 Psort location: nuclear, score: 23 YP_001586755.1 COG: COG4576 Carbon dioxide concentrating mechanism/carboxysome shell protein; Psort location: cytoplasmic, score: 23 YP_001586756.1 KEGG: rru:Rru_A0914 4.8e-100 aldehyde dehydrogenase K04021; COG: COG1012 NAD-dependent aldehyde dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001586757.1 COG: COG4820 Ethanolamine utilization protein, possible chaperonin; Psort location: cytoplasmic, score: 23 YP_001586758.1 KEGG: eci:UTI89_C2777 5.3e-181 eutG, yffV; ethanolamine utilization protein EutG iron-containing alcohol dehydrogenase K04022; COG: COG1454 Alcohol dehydrogenase, class IV; Psort location: cytoplasmic, score: 23 YP_001586759.1 KEGG: rsp:RSP_1788 0.0037 fruA; PTS system, fructose-specificIIBC component K02769:K02770; COG: COG3192 Ethanolamine utilization protein; Psort location: plasma membrane, score: 23 YP_001586760.1 ethanolamine utilization protein EutA YP_001586761.1 KEGG: spt:SPA0410 2.3e-242 eutB; ethanolamine ammonia-lyase heavy chain K03735; COG: COG4303 Ethanolamine ammonia-lyase, large subunit; Psort location: cytoplasmic, score: 23 YP_001586762.1 catalyzes the formation of acetaldehyde from ethanolamine YP_001586763.1 COG: COG4816 Ethanolamine utilization protein; Psort location: cytoplasmic, score: 23 YP_001586764.1 COG: COG4577 Carbon dioxide concentrating mechanism/carboxysome shell protein; Psort location: cytoplasmic, score: 23 YP_001586765.1 activates the transcription of the ethanolamine utilization operon YP_001586766.1 Psort location: mitochondrial, score: 23 YP_001586767.1 COG: NOG18511 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001586768.1 COG: NOG29106 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001586769.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis YP_001586770.1 KEGG: sty:STY2687 2.6e-149 amiA; probable N-acetylmuramoyl-L-alanine amidase K01448; COG: COG0860 N-acetylmuramoyl-L-alanine amidase; Psort location: mitochondrial, score: 23 YP_001586771.1 KEGG: eci:UTI89_C2767 7.6e-79 ypeA; hypothetical protein YpeA K00680; COG: COG0456 Acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001586772.1 COG: NOG08687 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001586773.1 COG: NOG06776 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001586774.1 KEGG: reh:H16_B0946 5.0e-43 predicted iron-dependent peroxidase K00430; COG: COG2837 Predicted iron-dependent peroxidase; Psort location: cytoplasmic, score: 23 YP_001586775.1 KEGG: stm:STM2445 6.0e-134 ucpA; putative oxidoreductase; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001586776.1 COG: COG4150 ABC-type sulfate transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001586777.1 KEGG: syn:sll0739 7.6e-30 modBC; ABC-type molybdate transport system permease/ATP-binding protein K02018; COG: COG0555 ABC-type sulfate transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001586778.1 Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import YP_001586779.1 KEGG: stm:STM2441 9.2e-193 cysA; ABC superfamily (atp_bind), sulfate permease A protein; chromate resistance K02045; COG: COG1118 ABC-type sulfate/molybdate transport systems, ATPase component; Psort location: cytoplasmic, score: 23 YP_001586780.1 catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide YP_001586781.1 KEGG: saz:Sama_2971 0.0011 peptidoglycan glycosyltransferase K05364; COG: COG0744 Membrane carboxypeptidase (penicillin-binding protein); Psort location: endoplasmic reticulum, score: 9 YP_001586782.1 COG: NOG10258 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001586783.1 Catalyzes the transfer of the ammonia group from glutamine to a new carbon-nitrogen group YP_001586784.1 KEGG: nwi:Nwi_0881 5.3e-25 transcriptional regulatory protein GntR family K00825; COG: COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs; Psort location: nuclear, score: 23 YP_001586785.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal YP_001586786.1 COG: NOG31214 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001586787.1 functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose YP_001586788.1 Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system YP_001586789.1 KEGG: bci:BCI_0069 1.5e-32 ptsH; phosphocarrier protein HPr K00890; COG: COG1925 Phosphotransferase system, HPr-related proteins; Psort location: cytoplasmic, score: 23 YP_001586790.1 Psort location: cytoplasmic, score: 23 YP_001586791.1 Psort location: extracellular, including cell wall, score: 9 YP_001586792.1 CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis YP_001586793.1 putative role in sulfur assimilation YP_001586794.1 interacts with cell division protein FitsZ and may be required to anchor septal ring structure YP_001586795.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB YP_001586796.1 KEGG: cmu:TC0823 0.00043 DNA polymerase III, epsilon subunit, putative K02342; COG: COG3530 Uncharacterized protein conserved in bacteria; Psort location: cytoskeletal, score: 9 YP_001586797.1 COG: COG0385 Predicted Na+-dependent transporter; Psort location: endoplasmic reticulum, score: 9 YP_001586798.1 KEGG: shn:Shewana3_3435 6.8e-23 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: mitochondrial, score: 23 YP_001586799.1 COG: NOG06876 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001586800.1 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation YP_001586801.1 KEGG: eci:UTI89_C3355 1.5e-135 nupG; transport of nucleosides, permease protein K03289; COG: NOG06211 non supervised orthologous group; Psort location: plasma membrane, score: 23 YP_001586802.1 COG: NOG19353 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001586803.1 KEGG: shn:Shewana3_3435 9.2e-19 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001586804.1 Psort location: nuclear, score: 23 YP_001586805.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_001586806.1 COG: NOG09785 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001586807.1 KEGG: xfa:XF1823 0.0090 tail-specific protease K03797; COG: NOG09771 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001586808.1 KEGG: shn:Shewana3_3829 1.1e-22 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) K01745; COG: COG2199 FOG: GGDEF domain; Psort location: endoplasmic reticulum, score: 23 YP_001586809.1 COG: COG1972 Nucleoside permease; Psort location: endoplasmic reticulum, score: 9 YP_001586810.1 Psort location: mitochondrial, score: 23 YP_001586811.1 COG: COG1914 Mn2+ and Fe2+ transporters of the NRAMP family; Psort location: plasma membrane, score: 23 YP_001586812.1 KEGG: vpa:VP2751 0.00027 penicillin-binding protein 1A K05366; COG: NOG09770 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001586813.1 KEGG: ret:RHE_CH02454 2.4e-107 probable oxidoreductase protein K05882; COG: COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001586814.1 Psort location: nuclear, score: 23 YP_001586815.1 KEGG: stm:STM2405 3.8e-297 indolepyruvate decarboxylase K01568; COG: COG3961 Pyruvate decarboxylase and related THIamine pyrophosphate-requiring enzymes; Psort location: cytoplasmic, score: 23 YP_001586816.1 KEGG: cpr:CPR_1400 3.5e-09 chloride channel protein K01529; COG: COG0038 Chloride channel protein EriC; Psort location: plasma membrane, score: 23 YP_001586817.1 catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate YP_001586818.1 Psort location: mitochondrial, score: 23 YP_001586819.1 KEGG: stm:STM2402 4.5e-223 yfdZ; putative aminotransferase; COG: COG0436 Aspartate/tyrosine/aromatic aminotransferase; Psort location: cytoplasmic, score: 23 YP_001586820.1 Psort location: nuclear, score: 23 YP_001586821.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(palmitoleoyl)-lipid IVA in cells subjected to cold shock YP_001586822.1 Psort location: cytoplasmic, score: 23 YP_001586823.1 COG: NOG13898 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001586824.1 KEGG: ptr:463007 0.0058 VNN2, LOC463007; vanin 2 K01463; COG: COG2271 Sugar phosphate permease; Psort location: plasma membrane, score: 23 YP_001586825.1 Psort location: endoplasmic reticulum, score: 9 YP_001586826.1 Psort location: cytoplasmic, score: 23 YP_001586827.1 COG: COG1840 ABC-type Fe3+ transport system, periplasmic component; Psort location: cytoplasmic, score: 23 YP_001586828.1 KEGG: stm:STM2397 0. pgtB; Phosphoglycerate transport: protein for signal transmission K08475; COG: COG4192 Signal transduction histidine kinase regulating phosphoglycerate transport system; Psort location: endoplasmic reticulum, score: 23 YP_001586829.1 KEGG: bms:BR1115 5.2e-32 ntrX; nitrogen regulation protein NtrX; COG: COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains; Psort location: cytoplasmic, score: 23 YP_001586830.1 outer membrane protease; involved in virulence in many organisms; OmpT; IcsP; SopA; Pla; PgtE; omptin; in Escherichia coli OmpT can degrade antimicrobial peptides; in Yersinia Pla activates plasminogen during infection; in Shigella flexneria SopA cleaves the autotransporter IcsA YP_001586831.1 KEGG: psp:PSPPH_4690 1.1e-09 formate transporter K00122; COG: COG2116 Formate/nitrite family of transporters; Psort location: plasma membrane, score: 23 YP_001586832.1 COG: COG2853 Surface lipoprotein; Psort location: extracellular, including cell wall, score: 9 YP_001586833.1 COG: COG2067 Long-chain fatty acid transport protein; Psort location: extracellular, including cell wall, score: 9 YP_001586834.1 Psort location: cytoplasmic, score: 23 YP_001586835.1 Psort location: nuclear, score: 23 YP_001586836.1 COG: COG3691 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001586837.1 FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth YP_001586838.1 multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate YP_001586839.1 Psort location: mitochondrial, score: 23 YP_001586840.1 KEGG: sec:SC2389 9.4e-65 sixA; phosphohistidine phosphatase K08296; COG: COG2062 Phosphohistidine phosphatase SixA; Psort location: cytoplasmic, score: 23 YP_001586841.1 Psort location: nuclear, score: 23 YP_001586842.1 COG: COG2840 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001586843.1 Psort location: cytoplasmic, score: 23 YP_001586844.1 involved in methylation of ribosomal protein L3 YP_001586845.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_001586846.1 D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm YP_001586847.1 COG: COG0730 Predicted permeases; Psort location: endoplasmic reticulum, score: 9 YP_001586848.1 COG: COG3101 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001586849.1 COG: NOG13546 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001586850.1 catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules YP_001586851.1 FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_001586852.1 COG: COG1266 Predicted metal-dependent membrane protease; Psort location: endoplasmic reticulum, score: 9 YP_001586853.1 COG: NOG26784 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001586854.1 COG: NOG18512 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001586855.1 COG: COG3423 Predicted transcriptional regulator; Psort location: nuclear, score: 23 YP_001586856.1 COG: NOG28278 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001586857.1 KEGG: eci:UTI89_C5041 1.2e-05 yjiJ; hypothetical protein YjiJ K00403; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001586858.1 in Salmonella typhimurium Flk regulates flagellar biosynthesis by inhibition of the flagellar-associated type III secretion system; lowers secretion levels of the anti-sigma28 factor FlgM to the periplasm; inner membrane-anchored protein YP_001586859.1 KEGG: sec:SC2372 5.0e-201 pdxB; erythronate-4-phosphate dehyrogenase K03473; COG: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001586860.1 KEGG: eci:UTI89_C2604 1.4e-159 usg; USG-1 protein K00133; COG: COG0136 Aspartate-semialdehyde dehydrogenase; Psort location: cytoplasmic, score: 23 YP_001586861.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_001586862.1 KEGG: lsl:LSL_1322 1.2e-14 alkaline phosphatase K01077; COG: COG0586 Uncharacterized membrane-associated protein; Psort location: endoplasmic reticulum, score: 9 YP_001586863.1 KEGG: sty:STY2597 1.1e-118 accD; acetyl-CoA carboxylase beta subunit K01963; COG: COG0777 Acetyl-CoA carboxylase beta subunit; Psort location: cytoplasmic, score: 23 YP_001586864.1 KEGG: stm:STM2365 6.4e-224 folC; multifunctional folylpolyglutamate synthase K01927:K01930; COG: COG0285 Folylpolyglutamate synthase; Psort location: cytoplasmic, score: 23 YP_001586865.1 KEGG: pfo:Pfl_1900 2.3e-13 argininosuccinate synthase K03749; COG: COG3147 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001586866.1 Psort location: cytoplasmic, score: 23 YP_001586867.1 membrane protein required for colicin V production YP_001586868.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_001586869.1 KEGG: eci:UTI89_C2502 1.9e-59 atoC; acetoacetate metabolism regulatory protein AtoC K07714; COG: COG3829 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains; Psort location: cytoplasmic, score: 23 YP_001586870.1 KEGG: stt:t0504 3.5e-255 putative amino acid decarboxylase K01586; COG: COG0019 Diaminopimelate decarboxylase; Psort location: cytoplasmic, score: 23 YP_001586871.1 KEGG: eci:UTI89_C0120 9.7e-06 aroP; aromatic amino acid transport protein AroP K03293; COG: COG0531 Amino acid transporters; Psort location: plasma membrane, score: 23 YP_001586872.1 KEGG: plt:Plut_0280 3.4e-05 alanine racemase region K01775; COG: COG3457 Predicted amino acid racemase; Psort location: cytoplasmic, score: 23 YP_001586873.1 KEGG: eci:UTI89_C0120 1.3e-60 aroP; aromatic amino acid transport protein AroP K03293; COG: COG0833 Amino acid transporters; Psort location: plasma membrane, score: 23 YP_001586874.1 catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate YP_001586875.1 Psort location: cytoplasmic, score: 23 YP_001586876.1 KEGG: bur:Bcep18194_A4695 2.1e-28 ABC polar amino acid transporter, periplasmic ligand binding protein K01713; COG: COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; Psort location: extracellular, including cell wall, score: 9 YP_001586877.1 KEGG: bur:Bcep18194_A4695 1.1e-29 ABC polar amino acid transporter, periplasmic ligand binding protein K01713; COG: COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; Psort location: extracellular, including cell wall, score: 9 YP_001586878.1 Psort location: mitochondrial, score: 23 YP_001586879.1 KEGG: sma:SAV6546 2.1e-21 putative ABC transporter permease K02028; COG: COG4215 ABC-type arginine transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001586880.1 KEGG: sma:SAV6546 5.1e-25 putative ABC transporter permease K02028; COG: COG4160 ABC-type arginine/histidine transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001586881.1 KEGG: stm:STM2351 4.2e-133 hisP; ABC superfamily (atp_bind), histidine and lysine/arginine/orniTHIne transport protein K02028; COG: COG4598 ABC-type histidine transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001586882.1 KEGG: ava:Ava_0206 1.7e-56 hypothetical protein; COG: COG1090 Predicted nucleoside-diphosphate sugar epimerase; Psort location: cytoplasmic, score: 23 YP_001586883.1 KEGG: eci:UTI89_C2586 1.5e-91 yfcG; putative S-transferase K00799; COG: COG0625 GlutaTHIone S-transferase; Psort location: cytoplasmic, score: 23 YP_001586884.1 KEGG: eci:UTI89_C2585 4.4e-90 yfcF; hypothetical protein K00799; COG: COG0625 GlutaTHIone S-transferase; Psort location: cytoplasmic, score: 23 YP_001586885.1 KEGG: eci:UTI89_C2584 4.5e-81 yfcE; hypothetical protein; COG: COG0622 Predicted phosphoesterase; Psort location: cytoplasmic, score: 23 YP_001586886.1 KEGG: ssn:SSO_2356 8.5e-87 putative regulator; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: cytoplasmic, score: 23 YP_001586887.1 KEGG: efa:EF1922 1.4e-05 transcriptional regulator, LacI family/carbohydrate kinase, PfkB family protein K00852; COG: COG1609 Transcriptional regulators; Psort location: mitochondrial, score: 23 YP_001586888.1 Psort location: nuclear, score: 23 YP_001586889.1 KEGG: stm:STM2344 4.9e-75 putative phosphotransferase system K02821; COG: COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type); Psort location: cytoplasmic, score: 23 YP_001586890.1 KEGG: spt:SPA0521 1.5e-41 putative sugar phosphotransferase component II B K02822; COG: COG3414 Phosphotransferase system, galactitol-specific IIB component; Psort location: cytoplasmic, score: 23 YP_001586891.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr YP_001586892.1 KEGG: stm:STM2341 7.0e-147 putative transketolase K00615; COG: COG3959 Transketolase, N-terminal subunit; Psort location: cytoplasmic, score: 23 YP_001586893.1 KEGG: sec:SC2341 8.7e-165 tktC; putative transketolase K00615; COG: COG3958 Transketolase, C-terminal subunit; Psort location: cytoplasmic, score: 23 YP_001586894.1 COG: COG1288 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001586895.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate YP_001586896.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA YP_001586897.1 Psort location: nuclear, score: 23 YP_001586898.1 Psort location: cytoplasmic, score: 23 YP_001586899.1 COG: COG3092 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001586900.1 COG: COG3013 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001586901.1 KEGG: eci:UTI89_C2575 2.2e-97 yfbT; protein YfbT K01112; COG: COG0637 Predicted phosphatase/phosphohexomutase; Psort location: cytoplasmic, score: 23 YP_001586902.1 KEGG: rxy:Rxyl_1626 0.0062 proton-translocating NADH-quinone oxidoreductase, chain M K05903; COG: COG0471 Di- and tricarboxylate transporters; Psort location: plasma membrane, score: 23 YP_001586903.1 KEGG: stm:STM2332 6.0e-102 putative hydrolase of HD superfamily K08722; COG: COG1896 Predicted hydrolases of HD superfamily; Psort location: mitochondrial, score: 23 YP_001586904.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor YP_001586905.1 KEGG: shn:Shewana3_3435 3.3e-05 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001586906.1 COG: NOG34329 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001586907.1 Psort location: cytoplasmic, score: 23 YP_001586908.1 Psort location: cytoplasmic, score: 23 YP_001586909.1 Catalyzes the transfer of electrons from NADH to quinone YP_001586910.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen YP_001586911.1 NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms YP_001586912.1 Catalyzes the transfer of electrons from NADH to quinone YP_001586913.1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase YP_001586914.1 Catalyzes the transfer of electrons from NADH to quinone YP_001586915.1 Catalyzes the transfer of electrons from NADH to quinone YP_001586916.1 Catalyzes the transfer of electrons from NADH to quinone YP_001586917.1 Catalyzes the transfer of electrons from NADH to quinone YP_001586918.1 Catalyzes the transfer of electrons from NADH to quinone YP_001586919.1 Catalyzes the transfer of electrons from NADH to ubiquinone YP_001586920.1 Catalyzes the transfer of electrons from NADH to quinone YP_001586921.1 Catalyzes the transfer of electrons from NADH to quinone YP_001586922.1 Psort location: cytoplasmic, score: 23 YP_001586923.1 Psort location: cytoplasmic, score: 23 YP_001586924.1 Psort location: endoplasmic reticulum, score: 9 YP_001586925.1 KEGG: eci:UTI89_C2553 3.1e-192 yfbK; hypothetical protein YfbK; COG: COG2304 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain; Psort location: extracellular, including cell wall, score: 9 YP_001586926.1 KEGG: stm:STM2314 6.9e-172 putative chemotaxis signal transduction protein K03415; COG: COG0784 FOG: CheY-like receiver; Psort location: cytoplasmic, score: 23 YP_001586927.1 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions YP_001586928.1 KEGG: vfi:VF0317 3.4e-28 acetyltransferase K02348; COG: COG2153 Predicted acyltransferase; Psort location: cytoplasmic, score: 23 YP_001586929.1 KEGG: pca:Pcar_1199 0.00094 MCP methyltransferase, CheR-type K00575; COG: COG4575 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001586930.1 KEGG: sec:SC2310 1.1e-233 menF; isochorismate synthase (isochorismate hydroxymutase 2), menaquinone biosynthesis K02552; COG: COG1169 Isochorismate synthase; Psort location: cytoplasmic, score: 23 YP_001586931.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis YP_001586932.1 catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA YP_001586933.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA YP_001586934.1 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate YP_001586935.1 KEGG: spt:SPA0558 2.7e-248 menE; O-succinylbenzoic acid-CoA ligase K01911; COG: COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II; Psort location: mitochondrial, score: 23 YP_001586936.1 KEGG: xac:XAC4286 0.0080 mutM; formamidopyrimidine DNA glycosylase K01248; COG: NOG11335 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001586937.1 COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: plasma membrane, score: 23 YP_001586938.1 COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001586939.1 catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A YP_001586940.1 KEGG: reh:H16_B1643 1.1e-40 predicted xylanase/chitin deacetylase K01463; COG: COG0726 Predicted xylanase/chitin deacetylase; Psort location: cytoplasmic, score: 23 YP_001586941.1 Bifunctional polymyxin resistance arnA protein; catalyzes the decarboxylation of UDP-glucuronic acid to UDP-4-keto-arabinose and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose to form UDP-L-4-formamido-arabinose; active in certain mutant strains YP_001586942.1 catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate YP_001586943.1 catalyzes the conversion of UDP-4-keto-arabinose to UDP-4-amino-4-deoxy-L-arabinose YP_001586944.1 Psort location: nuclear, score: 23 YP_001586945.1 COG: NOG08101 non supervised orthologous group; Psort location: golgi, score: 9 YP_001586946.1 KEGG: ecc:c2793 1.0e-65 yfaO; putative NUDIX hydrolase YfaO; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: cytoplasmic, score: 23 YP_001586947.1 COG: NOG08732 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001586948.1 Psort location: nuclear, score: 23 YP_001586949.1 KEGG: mmu:319945 1.4e-05 Flad1; RFad1, flavin adenine dinucleotide synthetase, homolog (yeast) K00953; COG: COG1058 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA; Psort location: cytoplasmic, score: 23 YP_001586950.1 COG: COG1414 Transcriptional regulator; Psort location: endoplasmic reticulum, score: 9 YP_001586951.1 KEGG: eci:UTI89_C2529 3.4e-218 yfaW; hypothetical protein YfaW K01781; COG: COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily; Psort location: cytoplasmic, score: 23 YP_001586952.1 KEGG: ani:AN1180.2 0.0028 hypothetical protein K04428; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001586953.1 KEGG: eci:UTI89_C2527 2.2e-120 yfaU; hypothetical protein YfaU K01636; COG: COG3836 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Psort location: cytoplasmic, score: 23 YP_001586954.1 COG: COG1058 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA; Psort location: mitochondrial, score: 23 YP_001586955.1 similar to ElaD; specific cysteine protease which targets ubiquitin and ubiquitin-like proteins covalently bound to target proteins; SseL in Salmonella is required for macrophage killing and virulence, and it is secreted by the salmonella pathogenicity island 2 type III secretion system YP_001586956.1 Psort location: cytoplasmic, score: 23 YP_001586957.1 anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate YP_001586958.1 sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters YP_001586959.1 anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor YP_001586960.1 Psort location: extracellular, including cell wall, score: 9 YP_001586961.1 catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell YP_001586962.1 hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic YP_001586963.1 KEGG: shn:Shewana3_3435 4.9e-20 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001586964.1 KEGG: shn:Shewana3_1692 1.1e-06 Xaa-His dipeptidase K01270; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001586965.1 plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases YP_001586966.1 B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA YP_001586967.1 Catalyzes the rate-limiting step in dNTP synthesis YP_001586968.1 Psort location: cytoplasmic, score: 23 YP_001586969.1 KEGG: stm:STM2276 1.5e-96 ubiG; 3-demethylubiquinone-9 3-methyltransferase and 2-octaprenyl-6-hydroxy phenol methylase K00568; COG: COG2227 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase; Psort location: cytoplasmic, score: 23 YP_001586970.1 Psort location: cytoplasmic, score: 23 YP_001586971.1 KEGG: msm:MSMEG_3400 9.7e-06 glutamyl-tRNA(Gln) amidotransferase subunit A K01957; COG: COG1802 Transcriptional regulators; Psort location: mitochondrial, score: 23 YP_001586972.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001586973.1 KEGG: pha:PSHAa0287 6.6e-112 mandelate racemase; COG: COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily; Psort location: cytoplasmic, score: 23 YP_001586974.1 Psort location: cytoplasmic, score: 23 YP_001586975.1 negatively supercoils closed circular double-stranded DNA YP_001586976.1 Psort location: mitochondrial, score: 23 YP_001586977.1 KEGG: stm:STM2271 0. rcsC; sensory histidine kinase in two-component regulatory system with RcsB, regulates colanic capsule biosynthesis K07677; COG: COG0784 FOG: CheY-like receiver; Psort location: endoplasmic reticulum, score: 23 YP_001586978.1 two-component response regulator RscB regulates the genes involved in capsule biosynthesis and cell division; probably phosphorylated by RcsC or RcsF YP_001586979.1 KEGG: stm:STM2269 0. yojN; putative sensor/kinase in regulatory system K07676; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 9 YP_001586980.1 Psort location: mitochondrial, score: 23 YP_001586981.1 allows for ions and hydrophilic solutes to cross the outer membrane YP_001586982.1 catalyzes the conversion of aminoimidazole ribotide to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine moiety of thiamine; involved in the maintenance and/or assembly of sulfur clusters; periplasmic lipoporotein anchored to the inner membrane; part of the thiamine pyrophosphate biosynthesis pathway YP_001586983.1 KEGG: spt:SPA0599 4.7e-189 ada; ADA regulatory protein K00567; COG: COG0350 Methylated DNA-protein cysteine methyltransferase; Psort location: cytoplasmic, score: 23 YP_001586984.1 COG: COG3145 Alkylated DNA repair protein; Psort location: cytoplasmic, score: 23 YP_001586985.1 efflux pump for the antibacterial peptide microcin J25 YP_001586986.1 Psort location: mitochondrial, score: 23 YP_001586987.1 serine protease inhibitor, inhibits trypsin and other proteases YP_001586988.1 Psort location: nuclear, score: 23 YP_001586989.1 Predicted role in electron transfer to the periplasmic nitrate reductase protein NapA. YP_001586990.1 KEGG: eci:UTI89_C2485 3.2e-32 napD; NapD protein, subunit of nitrate reductase, periplasmic K02570; COG: COG3062 Uncharacterized protein involved in formation of periplasmic nitrate reductase; Psort location: cytoplasmic, score: 23 YP_001586991.1 periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC YP_001586992.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway YP_001586993.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA YP_001586994.1 small subunit of periplasmic nitrate reductase; receives electrons from the membrane-bound NapC and passes them to NapA YP_001586995.1 with NapABDFGH functions as a nitrate reductase; NapC functions as an electron shuttle between NapAB and NapGH or quinone YP_001586996.1 ATP-binding protein; required for proper cytochrome c maturation YP_001586997.1 COG: COG2386 ABC-type transport system involved in cytochrome c biogenesis, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001586998.1 KEGG: vfi:VF1822 5.2e-80 heme chaperone heme-lyase K02195; COG: COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001586999.1 COG: COG3114 Heme exporter protein D; Psort location: cytoplasmic, score: 23 YP_001587000.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane YP_001587001.1 KEGG: vfi:VF1819 8.1e-217 heme chaperone--apocytochrome heme-lyase K02198; COG: COG1138 Cytochrome c biogenesis factor; Psort location: plasma membrane, score: 23 YP_001587002.1 KEGG: azo:azo3929 3.3e-30 ccmG; protein disulfide-isomerase K01829; COG: COG0526 Thiol-disulfide isomerase and THIoredoxins; Psort location: extracellular, including cell wall, score: 9 YP_001587003.1 KEGG: stm:STM4281 1.4e-20 nrfE; putative methylase K04016; COG: COG3088 Uncharacterized protein involved in biosynthesis of c-type cytochromes; Psort location: endoplasmic reticulum, score: 9 YP_001587004.1 nitrate/nitrite response regulator NarP; NarP is phosphorylated by NarX and NarQ and can activate fdnG and nitrite or nitrate reductase systems; represses expression of other anaerobic genes YP_001587005.1 Psort location: cytoplasmic, score: 23 YP_001587006.1 KEGG: xtr:548509 0.0015 MGC108396; MGC108396 protein K01312; COG: NOG31164 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001587007.1 COG: NOG33844 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587008.1 Psort location: mitochondrial, score: 23 YP_001587009.1 COG: COG5301 Phage-related tail fibre protein; Psort location: cytoplasmic, score: 23 YP_001587010.1 Psort location: mitochondrial, score: 23 YP_001587011.1 Psort location: nuclear, score: 23 YP_001587012.1 Psort location: cytoplasmic, score: 23 YP_001587013.1 KEGG: hsa:23239 8.5e-10 PHLPP, PLEKHE1; PH domain and leucine rich repeat protein phosphatase K01090; COG: COG4886 Leucine-rich repeat (LRR) protein; Psort location: cytoplasmic, score: 23 YP_001587014.1 COG: NOG17190 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001587015.1 Psort location: mitochondrial, score: 23 YP_001587016.1 COG: NOG25302 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587017.1 COG: NOG15377 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587018.1 COG: COG4928 Predicted P-loop ATPase; Psort location: cytoplasmic, score: 23 YP_001587019.1 Psort location: cytoplasmic, score: 23 YP_001587020.1 COG: NOG19594 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001587021.1 COG: COG3740 Phage head maturation protease; Psort location: cytoplasmic, score: 23 YP_001587022.1 COG: NOG20217 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587023.1 COG: COG5525 Bacteriophage tail assembly protein; Psort location: cytoplasmic, score: 23 YP_001587024.1 COG: NOG11457 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001587025.1 KEGG: azo:azo3580 2.9e-61 putative acyltransferase family protein K00680; COG: COG1835 Predicted acyltransferases; Psort location: plasma membrane, score: 23 YP_001587026.1 Psort location: cytoplasmic, score: 23 YP_001587027.1 KEGG: stm:STM2230.1c 1.1e-79 DNA polymerase V subunit; COG: COG1974 SOS-response transcriptional repressors (RecA-mediated autopeptidases); Psort location: cytoplasmic, score: 23 YP_001587028.1 KEGG: aha:AHA_1664 5.8e-104 putative sulfatase; COG: COG3083 Predicted hydrolase of alkaline phosphatase superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001587029.1 COG: COG3082 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001587030.1 COG: COG3081 Nucleoid-associated protein; Psort location: cytoplasmic, score: 23 YP_001587031.1 COG: NOG25034 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001587032.1 Psort location: nuclear, score: 23 YP_001587033.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_001587034.1 KEGG: eci:UTI89_C2461 0. yejH; hypothetical protein YejH K01529; COG: COG1061 DNA or RNA helicases of superfamily II; Psort location: cytoplasmic, score: 23 YP_001587035.1 catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA YP_001587036.1 Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance YP_001587037.1 Psort location: mitochondrial, score: 23 YP_001587038.1 COG: NOG14216 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001587039.1 KEGG: pen:PSEEN3568 1.4e-155 ABC transporter, ATP-binding protein; COG: COG4172 ABC-type uncharacterized transport system, duplicated ATPase component; Psort location: cytoplasmic, score: 23 YP_001587040.1 KEGG: syf:Synpcc7942_2454 4.3e-05 adenine phosphoribosyltransferase K00759; COG: COG4239 ABC-type uncharacterized transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001587041.1 KEGG: syf:Synpcc7942_2454 1.5e-32 adenine phosphoribosyltransferase K00759; COG: COG4174 ABC-type uncharacterized transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001587042.1 COG: COG4166 ABC-type oligopeptide transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001587043.1 KEGG: vfi:VF0494 9.2e-32 sensory transduction protein kinase; COG: COG2200 FOG: EAL domain; Psort location: endoplasmic reticulum, score: 9 YP_001587044.1 Psort location: nuclear, score: 23 YP_001587045.1 Psort location: nuclear, score: 23 YP_001587046.1 by similarity, Spr seems to have peptidase activity; involved in thermoresistance YP_001587047.1 Psort location: mitochondrial, score: 23 YP_001587048.1 KEGG: eci:UTI89_C2451 3.0e-100 hypothetical protein K01094; COG: COG0671 Membrane-associated phospholipid phosphatase; Psort location: endoplasmic reticulum, score: 9 YP_001587049.1 KEGG: reh:H16_A3373 6.7e-16 putative GTPase (G3E family); COG: COG0523 Putative GTPases (G3E family); Psort location: cytoplasmic, score: 23 YP_001587050.1 Stimulates the peptidyltransferase activity of the 70S ribosome and enhances dipeptide synthesis with N-formylmethionyl-tRNA and puromycin in vitro, suggesting its involvement in the formation of the first peptide bond of a protein YP_001587051.1 COG: NOG28525 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001587052.1 Psort location: cytoplasmic, score: 23 YP_001587053.1 Psort location: cytoplasmic, score: 23 YP_001587054.1 Psort location: cytoplasmic, score: 23 YP_001587055.1 COG: NOG23005 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001587056.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001587057.1 Psort location: nuclear, score: 23 YP_001587058.1 Psort location: cytoplasmic, score: 23 YP_001587059.1 phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr YP_001587060.1 converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers YP_001587061.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_001587062.1 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues YP_001587063.1 Psort location: cytoplasmic, score: 23 YP_001587064.1 COG: COG2855 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001587065.1 KEGG: shn:Shewana3_3435 1.1e-08 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001587066.1 Psort location: mitochondrial, score: 23 YP_001587067.1 KEGG: eci:UTI89_C0120 2.6e-69 aroP; aromatic amino acid transport protein AroP K03293; COG: COG0833 Amino acid transporters; Psort location: plasma membrane, score: 23 YP_001587068.1 Psort location: cytoplasmic, score: 23 YP_001587069.1 Cir; FeuA; CirA; receptor protein for siderophores (colicin IA, IB and V) and microcins (E492, H47, and M); TonB-dependent; able to transport monomers, dimer, and linear trimers of 2,3-dihydorxybenzoylserine; outer membrane protein YP_001587070.1 COG: COG2271 Sugar phosphate permease; Psort location: plasma membrane, score: 23 YP_001587071.1 KEGG: aba:Acid345_2803 2.1e-44 phosphoserine phosphatase SerB K01079; COG: COG0560 Phosphoserine phosphatase; Psort location: cytoplasmic, score: 23 YP_001587072.1 Psort location: mitochondrial, score: 23 YP_001587073.1 KEGG: sec:SC2212 7.7e-244 sdhL; putative D-serine dehydratase K01752; COG: COG1760 L-serine deaminase; Psort location: endoplasmic reticulum, score: 9 YP_001587074.1 COG: COG1396 Predicted transcriptional regulators; Psort location: nuclear, score: 23 YP_001587075.1 KEGG: spt:SPA0657 2.5e-158 yeiG; putative esterase K03929; COG: COG0627 Predicted esterase; Psort location: cytoplasmic, score: 23 YP_001587076.1 Psort location: mitochondrial, score: 23 YP_001587077.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer YP_001587078.1 COG: COG2311 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 23 YP_001587079.1 Psort location: endoplasmic reticulum, score: 9 YP_001587080.1 negative regulator of the mglBAC operon for galactose utilization YP_001587081.1 Psort location: cytoplasmic, score: 23 YP_001587082.1 KEGG: msm:MSMEG_3095 7.4e-13 D-ribose-binding periplasmic protein; COG: COG1879 ABC-type sugar transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001587083.1 Psort location: mitochondrial, score: 23 YP_001587084.1 with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains YP_001587085.1 ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex YP_001587086.1 catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines YP_001587087.1 function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain YP_001587088.1 COG: NOG13896 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587089.1 COG: COG2949 Uncharacterized membrane protein; Psort location: extracellular, including cell wall, score: 9 YP_001587090.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis YP_001587091.1 KEGG: bcz:BCZK3376 1.8e-29 murein hydrolase export regulator K01238; COG: COG1346 Putative effector of murein hydrolase; Psort location: endoplasmic reticulum, score: 9 YP_001587092.1 KEGG: btk:BT9727_3424 3.1e-11 murein hydrolase exporter K06518; COG: COG1380 Putative effector of murein hydrolase LrgA; Psort location: endoplasmic reticulum, score: 9 YP_001587093.1 KEGG: shn:Shewana3_3435 8.5e-11 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001587094.1 KEGG: cal:orf19.4384 1.4e-10 HXT10; fructose symporter K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001587095.1 KEGG: stt:t0677 4.1e-190 putative gentisate 1,2-dioxygenase K00450; COG: COG3435 Gentisate 1,2-dioxygenase; Psort location: cytoplasmic, score: 23 YP_001587096.1 KEGG: reh:H16_B0874 9.9e-93 fumarylpyruvate hydrolase K01557; COG: COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway); Psort location: cytoplasmic, score: 23 YP_001587097.1 KEGG: pen:PSEEN2595 1.8e-63 mhbI; maleylpyruvate isomerase K01800; COG: COG0625 GlutaTHIone S-transferase; Psort location: cytoplasmic, score: 23 YP_001587098.1 catalyzes the formation of catechol from salicylate YP_001587099.1 KEGG: sec:SC2191 2.9e-166 yohI; putative nitrogen regulation protein K05541; COG: COG0042 tRNA-dihydrouridine synthase; Psort location: cytoplasmic, score: 23 YP_001587100.1 Psort location: cytoplasmic, score: 23 YP_001587101.1 COG: NOG33037 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587102.1 Psort location: cytoplasmic, score: 23 YP_001587103.1 may be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride YP_001587104.1 KEGG: stt:t0684 3.0e-132 yohF; putative oxidoreductase; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001587105.1 KEGG: oih:OB2407 0.00065 alkaline phosphatase K01077; COG: COG0586 Uncharacterized membrane-associated protein; Psort location: endoplasmic reticulum, score: 9 YP_001587106.1 Psort location: mitochondrial, score: 23 YP_001587107.1 COG: NOG06773 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001587108.1 specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7 YP_001587109.1 component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent YP_001587110.1 Psort location: mitochondrial, score: 23 YP_001587111.1 KEGG: stm:STM2166 0. bglX; beta-D-glucoside glucohydrolase, periplasmic K05349; COG: COG1472 Beta-glucosidase-related glycosidases; Psort location: cytoplasmic, score: 23 YP_001587112.1 KEGG: lwe:lwe1439 3.9e-25 glycine betaine/L-proline ABC transporter, permease/glycine betaine/L-proline-binding protein; COG: COG1732 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein); Psort location: extracellular, including cell wall, score: 9 YP_001587113.1 KEGG: lwe:lwe1439 9.1e-35 glycine betaine/L-proline ABC transporter, permease/glycine betaine/L-proline-binding protein; COG: COG1174 ABC-type proline/glycine betaine transport systems, permease component; Psort location: plasma membrane, score: 23 YP_001587114.1 KEGG: bur:Bcep18194_B0497 4.4e-67 ABC proline/glycine betaine transporter, ATPase subunit K05847; COG: COG1125 ABC-type proline/glycine betaine transport systems, ATPase components; Psort location: cytoplasmic, score: 23 YP_001587115.1 KEGG: lwe:lwe1439 8.2e-34 glycine betaine/L-proline ABC transporter, permease/glycine betaine/L-proline-binding protein; COG: COG1174 ABC-type proline/glycine betaine transport systems, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001587116.1 COG: NOG18136 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587117.1 KEGG: eci:UTI89_C3737 3.0e-07 yhdM; Zn(II)-responsive regulator of ZntA; COG: COG0789 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001587118.1 KEGG: stm:STM2159 4.5e-294 yehU; paral putative sensor/kinase in regulatory system K07704; COG: COG3275 Putative regulator of cell autolysis; Psort location: endoplasmic reticulum, score: 9 YP_001587119.1 unknown function; when overproduced it confers drug-resistance YP_001587120.1 COG: COG4807 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001587121.1 COG: COG4808 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001587122.1 COG: COG4808 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001587123.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_001587124.1 KEGG: eci:UTI89_C2387 1.1e-191 mrp; putative ATPase K03593; COG: COG0489 ATPases involved in chromosome partitioning; Psort location: cytoplasmic, score: 23 YP_001587125.1 COG: NOG18135 non supervised orthologous group; Psort location: golgi, score: 9 YP_001587126.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001587127.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: nuclear, score: 23 YP_001587128.1 COG: COG3188 P pilus assembly protein, porin PapC; Psort location: extracellular, including cell wall, score: 9 YP_001587129.1 COG: NOG07909 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001587130.1 Psort location: nuclear, score: 23 YP_001587131.1 COG: COG5455 Predicted integral membrane protein; Psort location: extracellular, including cell wall, score: 9 YP_001587132.1 Psort location: nuclear, score: 23 YP_001587133.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP YP_001587134.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine YP_001587135.1 KEGG: reh:H16_B1289 1.2e-13 phnF; regulator of phosphonate operon, GntR-family; COG: COG2188 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001587136.1 KEGG: bcl:ABC3643 1.3e-17 ribokinase K00852; COG: COG0524 Sugar kinases, ribokinase family; Psort location: mitochondrial, score: 23 YP_001587137.1 KEGG: stm:STM2143 1.1e-175 yegU; putative glycohydrolase K05521; COG: COG1397 ADP-ribosylglycohydrolase; Psort location: mitochondrial, score: 23 YP_001587138.1 KEGG: eci:UTI89_C3355 4.3e-53 nupG; transport of nucleosides, permease protein K03289; COG: NOG06278 non supervised orthologous group; Psort location: plasma membrane, score: 23 YP_001587139.1 catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate YP_001587140.1 cytosolic protein with phosphatidylglycerol kinase activity; undetermined physiological role YP_001587141.1 Psort location: mitochondrial, score: 23 YP_001587142.1 Psort location: cytoplasmic, score: 23 YP_001587143.1 COG: NOG28778 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587144.1 Psort location: nuclear, score: 23 YP_001587145.1 KEGG: stm:STM2136 1.7e-248 yegQ; putative protease K08303; COG: COG0826 Collagenase and related proteases; Psort location: cytoplasmic, score: 23 YP_001587146.1 COG: NOG06226 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587147.1 COG: NOG24988 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587148.1 COG: NOG26588 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001587149.1 response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport YP_001587150.1 KEGG: sec:SC2132 5.5e-250 baeS, baeR; sensory kinase in two-component regulatoyr system wtih BaeR K07642; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 9 YP_001587151.1 KEGG: sgl:SG1466 2.2e-07 deTHIobiotin synthase K01935; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001587152.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC; confers resistance against novobiocin and deoxycholate YP_001587153.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate YP_001587154.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate YP_001587155.1 Psort location: nuclear, score: 23 YP_001587156.1 KEGG: mbo:Mb0358 1.3e-07 dnaK; probable chaperone protein DnaK (heat shock protein 70) (heat shock 70 kda protein) (HSP70) K04043; COG: COG0443 Molecular chaperone; Psort location: cytoplasmic, score: 23 YP_001587157.1 inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine YP_001587158.1 KEGG: eci:UTI89_C2343 0. yegE; putative sensor-type protein; COG: COG2199 FOG: GGDEF domain; Psort location: plasma membrane, score: 23 YP_001587159.1 Psort location: cytoplasmic, score: 23 YP_001587160.1 Psort location: cytoplasmic, score: 23 YP_001587161.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor YP_001587162.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis YP_001587163.1 YegA; inner membrane protein involved in the assembly of outer membrane proteins (OMPs); asmA-null mutants show low lipopolysaccharide (LPS) levels, suggesting a role in LPS biogenesis and/or in restricting outer membrane fluidity, resulting on altered assembly of OMPs YP_001587164.1 KEGG: eci:UTI89_C0656 1.0e-24 ybeX; putative transport protein K06189; COG: COG1253 Hemolysins and related proteins containing CBS domains; Psort location: plasma membrane, score: 23 YP_001587165.1 Psort location: cytoplasmic, score: 23 YP_001587166.1 Psort location: cytoplasmic, score: 23 YP_001587167.1 COG: COG1596 Periplasmic protein involved in polysaccharide export; Psort location: cytoplasmic, score: 23 YP_001587168.1 Wzb shows phosphatase activity towards the autophosphorylated Wzc protein, which induces colanic acid biosynthesis; catalyzes the phosphorylation of UDP-glucose dehydrogenase, an enzyme involved in colanic acid biosynthesis YP_001587169.1 Wzc; catalyzes the autophosphorylation on tyrosine residues which downregulates the biosynthesis of colonic acid (an extracellular polysaccharide) YP_001587170.1 KEGG: eci:UTI89_C2333 2.0e-140 wcaA; putative colanic acid biosynthesis glycosyltransferase WcaA; COG: COG0463 Glycosyltransferases involved in cell wall biogenesis; Psort location: mitochondrial, score: 23 YP_001587171.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); wcaB is induced in sessile bacteria and by osmotic shock, and repressed when grown in rich medium YP_001587172.1 KEGG: eci:UTI89_C2331 9.6e-182 wcaC; putative glycosyltransferase K00754; COG: COG0438 Glycosyltransferase; Psort location: cytoplasmic, score: 23 YP_001587173.1 essential for colanic acid biosynthesis; colanic acid is an exopolysaccharide produced under stress conditions that confers acid and heat tolerance YP_001587174.1 KEGG: eci:UTI89_C2329 5.3e-94 wcaE; putative colanic acid biosynthesis glycosyl transferase; COG: COG0463 Glycosyltransferases involved in cell wall biogenesis; Psort location: cytoplasmic, score: 23 YP_001587175.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit) YP_001587176.1 KEGG: stm:STM2109 1.7e-200 gmd; GDP-D-mannose dehydratase K01711; COG: COG1089 GDP-D-mannose dehydratase; Psort location: cytoplasmic, score: 23 YP_001587177.1 KEGG: stm:STM2108 4.7e-173 wcaG; bifunctional GDP fucose synthetase in colanic acid biosyntheis K02377; COG: COG0451 Nucleoside-diphosphate-sugar epimerases; Psort location: cytoplasmic, score: 23 YP_001587178.1 KEGG: sec:SC2108 8.2e-82 wcaI; putative glycosyl transferase in colanic acid biosynthesis K03207; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: cytoplasmic, score: 23 YP_001587179.1 KEGG: eci:UTI89_C2324 6.7e-190 wcaI; putative colanic biosynthesis glycosyl transferase K03208; COG: COG0438 Glycosyltransferase; Psort location: cytoplasmic, score: 23 YP_001587180.1 KEGG: sec:SC2106 2.0e-261 manC; mannose-1-phosphate in colanic acid gene cluster K00971; COG: COG0662 Mannose-6-phosphate isomerase; Psort location: cytoplasmic, score: 23 YP_001587181.1 KEGG: stm:STM2104 6.9e-243 cpsG; phosphomannomutase in colanic acid gene cluster K01840; COG: COG1109 Phosphomannomutase; Psort location: cytoplasmic, score: 23 YP_001587182.1 WcaJ; glucose-1-phosphate transferase responsible for the addition of the first glucose-1-phosphate from UDP-glucose to the lipid carrier undecaprenyl phosphate in the biosynthesis of colanic acid YP_001587183.1 COG: COG2244 Membrane protein involved in the export of O-antigen and teichoic acid; Psort location: plasma membrane, score: 23 YP_001587184.1 KEGG: sbo:SBO_0872 1.3e-156 wcaK; putative galactokinase K00849; COG: COG2327 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001587185.1 KEGG: stm:STM2100 8.6e-213 wcaL; putative glycosyl transferase in colanic acid gene cluster; COG: COG0438 Glycosyltransferase; Psort location: cytoplasmic, score: 23 YP_001587186.1 WcaM from Salmonella enterica is essential for biofilm formation on HEp-2 cells and chicken intestinal tissue but not on a plastic surface; may be involved in the biosynthesis of colanic acid YP_001587187.1 together with GalU subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose YP_001587188.1 NAD(P) binding; catalyzes the formation of dTDP-4-dehydro-6-deoxy-D-glucose from dTDP-glucose YP_001587189.1 with dTDP-4-dehydrorhamnose 3,5-epimerase forms a complex known as dTDP-L-rhamnose synthetase; catalyzes the reduction of dTDP-4-dehydro-6-deoxy-L-mannose to dTDP-L-rhamnose YP_001587190.1 KEGG: spt:SPA0771 6.4e-153 rfbA; TDP-glucose pyrophosphorylase K00973; COG: COG1209 dTDP-glucose pyrophosphorylase; Psort location: cytoplasmic, score: 23 YP_001587191.1 KEGG: sty:STY2304 9.6e-95 rfbC; dTDP-4-dehydrorhamnose 3,5-epimerase K01790; COG: COG1898 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes; Psort location: cytoplasmic, score: 23 YP_001587192.1 catalyzes the formation of 3,6-dideoxy-D-glycero-D-glycero-4-hexulose YP_001587193.1 KEGG: stm:STM2092 5.3e-142 rfbF; glucose-1-phosphate cytidylyltransferase K00978; COG: COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon); Psort location: cytoplasmic, score: 23 YP_001587194.1 KEGG: stm:STM2091 1.3e-200 rfbG; CDP-glucose 4,6-dehydratase K01709; COG: COG0451 Nucleoside-diphosphate-sugar epimerases; Psort location: cytoplasmic, score: 23 YP_001587195.1 KEGG: vfi:VF0184 4.3e-195 CDP-4-dehydro-6-deoxy-D-glucose 3-dehydratase K01726; COG: COG0399 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis; Psort location: cytoplasmic, score: 23 YP_001587196.1 KEGG: stm:STM2089 6.5e-160 rfbJ; LPS side chain defect: CDP-abequose synthase K01726; COG: COG0451 Nucleoside-diphosphate-sugar epimerases; Psort location: cytoplasmic, score: 23 YP_001587197.1 KEGG: pto:PTO1028 2.0e-06 NADH-quinone oxidoreductase chain M K00342; COG: COG2244 Membrane protein involved in the export of O-antigen and teichoic acid; Psort location: plasma membrane, score: 23 YP_001587198.1 KEGG: mge:MG_060 2.9e-10 glycosyl transferase, group 2 family protein K00754; COG: COG0463 Glycosyltransferases involved in cell wall biogenesis; Psort location: cytoplasmic, score: 23 YP_001587199.1 Psort location: cytoplasmic, score: 23 YP_001587200.1 KEGG: aae:aq_515 3.4e-28 mtfB; mannosyltransferase B K00754; COG: COG0438 Glycosyltransferase; Psort location: cytoplasmic, score: 23 YP_001587201.1 KEGG: stm:STM2085 3.1e-169 rfbN; LPS side chain defect: rhamnosyl transferase K00754; COG: COG0463 Glycosyltransferases involved in cell wall biogenesis; Psort location: cytoplasmic, score: 23 YP_001587202.1 KEGG: stm:STM2084 2.3e-260 rfbM; mannose-1-phosphate guanylyltransferase K00971; COG: COG0662 Mannose-6-phosphate isomerase; Psort location: cytoplasmic, score: 23 YP_001587203.1 KEGG: stm:STM2083 2.0e-252 rfbK; LPS side chain defect: phosphomannomutase K01840; COG: COG1109 Phosphomannomutase; Psort location: endoplasmic reticulum, score: 9 YP_001587204.1 KEGG: stm:STM2082 6.3e-265 rfbP; LPS side chain defect: bifunctional enzyme: undecaprenol-phosphate galactosephosphotransferase, and O-antigen transfer K00996; COG: COG2148 Sugar transferases involved in lipopolysaccharide synthesis; Psort location: endoplasmic reticulum, score: 9 YP_001587205.1 Psort location: cytoplasmic, score: 23 YP_001587206.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate YP_001587207.1 Psort location: endoplasmic reticulum, score: 9 YP_001587208.1 KEGG: stm:STM2080 2.7e-202 udg; UDP-glucose/GDP-mannose dehydrogenase K00012; COG: COG1004 Predicted UDP-glucose 6-dehydrogenase; Psort location: cytoplasmic, score: 23 YP_001587209.1 KEGG: pfo:Pfl_3844 1.1e-06 lipopolysaccharide biosynthesis K00903; COG: COG3765 Chain length determinant protein; Psort location: endoplasmic reticulum, score: 9 YP_001587210.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis YP_001587211.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase YP_001587212.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide YP_001587213.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide YP_001587214.1 catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate YP_001587215.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_001587216.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_001587217.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors YP_001587218.1 Psort location: mitochondrial, score: 23 YP_001587219.1 KEGG: bsu:BG13829 7.7e-08 ytcB; similar to NDP-sugar epimerase; COG: COG0451 Nucleoside-diphosphate-sugar epimerases; Psort location: endoplasmic reticulum, score: 9 YP_001587220.1 KEGG: shn:Shewana3_3435 0.00095 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001587221.1 Psort location: mitochondrial, score: 23 YP_001587222.1 KEGG: eci:UTI89_C0120 2.9e-15 aroP; aromatic amino acid transport protein AroP K03293; COG: COG0531 Amino acid transporters; Psort location: plasma membrane, score: 23 YP_001587223.1 Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates YP_001587224.1 Psort location: endoplasmic reticulum, score: 9 YP_001587225.1 COG: COG0582 Integrase; Psort location: cytoplasmic, score: 23 YP_001587226.1 COG: NOG30287 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001587227.1 KEGG: stt:t1926 2.4e-146 putative DNA methylase K06223; COG: COG0338 Site-specific DNA methylase; Psort location: cytoplasmic, score: 23 YP_001587228.1 KEGG: stt:t1924 5.8e-120 exo; exonuclease K01143; COG: NOG07914 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587229.1 COG: NOG18528 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587230.1 COG: NOG14124 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587231.1 Psort location: cytoplasmic, score: 23 YP_001587232.1 Psort location: cytoplasmic, score: 23 YP_001587233.1 Psort location: cytoplasmic, score: 23 YP_001587234.1 COG: COG1396 Predicted transcriptional regulators; Psort location: nuclear, score: 23 YP_001587235.1 Psort location: mitochondrial, score: 23 YP_001587236.1 COG: NOG24659 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587237.1 COG: NOG18590 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001587238.1 COG: NOG20728 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001587239.1 Psort location: cytoplasmic, score: 23 YP_001587240.1 COG: NOG16865 non supervised orthologous group; Psort location: cytoskeletal, score: 9 YP_001587241.1 COG: NOG27404 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587242.1 COG: NOG22010 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587243.1 COG: NOG13881 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587244.1 COG: NOG30773 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587245.1 Psort location: nuclear, score: 23 YP_001587246.1 COG: NOG18526 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587247.1 COG: NOG29483 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587248.1 COG: NOG06198 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587249.1 Psort location: cytoplasmic, score: 23 YP_001587250.1 COG: NOG14016 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001587251.1 COG: NOG24469 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587252.1 COG: NOG28546 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587253.1 COG: NOG19594 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587254.1 KEGG: cvi:CV0024 7.7e-05 probable hydroxyethylTHIazole kinase K00878; COG: COG3179 Predicted chitinase; Psort location: cytoplasmic, score: 23 YP_001587255.1 KEGG: stm:STM0908 1.5e-05 Fels-1 prophage K01423; COG: NOG11447 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001587256.1 Psort location: cytoplasmic, score: 23 YP_001587257.1 COG: NOG06766 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001587258.1 COG: NOG14015 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587259.1 Psort location: cytoplasmic, score: 23 YP_001587260.1 Psort location: nuclear, score: 23 YP_001587261.1 KEGG: eci:UTI89_C0735 4.9e-12 tolA; membrane spanning protein TolA K03646; COG: COG5022 Myosin heavy chain; Psort location: cytoplasmic, score: 23 YP_001587262.1 COG: NOG14665 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587263.1 Psort location: cytoplasmic, score: 23 YP_001587264.1 Psort location: nuclear, score: 23 YP_001587265.1 Psort location: extracellular, including cell wall, score: 9 YP_001587266.1 Psort location: cytoplasmic, score: 23 YP_001587267.1 Psort location: cytoplasmic, score: 23 YP_001587268.1 Psort location: cytoplasmic, score: 23 YP_001587269.1 Psort location: cytoplasmic, score: 23 YP_001587270.1 Psort location: cytoplasmic, score: 23 YP_001587271.1 Psort location: cytoplasmic, score: 23 YP_001587272.1 COG: NOG14677 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587273.1 Psort location: cytoplasmic, score: 23 YP_001587274.1 Psort location: cytoplasmic, score: 23 YP_001587275.1 Psort location: cytoplasmic, score: 23 YP_001587276.1 Psort location: cytoplasmic, score: 23 YP_001587277.1 Psort location: cytoplasmic, score: 23 YP_001587278.1 COG: COG3299 Uncharacterized homolog of phage Mu protein gp47; Psort location: cytoplasmic, score: 23 YP_001587279.1 Psort location: cytoplasmic, score: 23 YP_001587280.1 COG: COG5295 Autotransporter adhesin; Psort location: cytoplasmic, score: 23 YP_001587281.1 COG: NOG18524 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587282.1 COG: NOG31945 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587283.1 KEGG: bxe:Bxe_C1379 8.0e-36 putative acyltransferase transmembrane protein K00680; COG: COG1835 Predicted acyltransferases; Psort location: plasma membrane, score: 23 YP_001587284.1 COG: NOG18514 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587285.1 COG: COG5525 Bacteriophage tail assembly protein; Psort location: nuclear, score: 23 YP_001587286.1 Psort location: cytoplasmic, score: 23 YP_001587287.1 Psort location: cytoplasmic, score: 23 YP_001587288.1 Psort location: cytoplasmic, score: 23 YP_001587289.1 Psort location: nuclear, score: 23 YP_001587290.1 Psort location: golgi, score: 9 YP_001587291.1 Psort location: endoplasmic reticulum, score: 9 YP_001587292.1 KEGG: stm:STM2065 0. phsA; Hydrogen sulfide production: membrane anchoring protein K08352; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: extracellular, including cell wall, score: 9 YP_001587293.1 KEGG: eci:UTI89_C1863 2.1e-51 putative oxidoreductase Fe-S subunit K00178; COG: COG0437 Fe-S-cluster-containing hydrogenase components 1; Psort location: cytoplasmic, score: 23 YP_001587294.1 KEGG: pol:Bpro_0940 1.3e-07 formate dehydrogenase, gamma subunit K00127; COG: COG4117 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein); Psort location: endoplasmic reticulum, score: 9 YP_001587295.1 removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; penicillin-binding protein 6B; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains YP_001587296.1 COG: COG3449 DNA gyrase inhibitor; Psort location: cytoplasmic, score: 23 YP_001587297.1 COG: COG1289 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001587298.1 Psort location: nuclear, score: 23 YP_001587299.1 KEGG: pac:PPA1242 0.0036 ATP synthase delta chain K02113; COG: COG2926 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001587300.1 KEGG: lwe:lwe1128 2.0e-48 propanediol utilization kinase PduX K01009; COG: COG4542 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase; Psort location: cytoskeletal, score: 9 YP_001587301.1 involved in coenzyme B(12)-dependent 1, 2-propanediol degradation; important for the synthesis of propionyl coenzyme A during growth on 1,2-propanediol YP_001587302.1 KEGG: eci:UTI89_C2785 1.6e-12 eutP; ethanolamine utilization protein EutP K04029; COG: COG4917 Ethanolamine utilization protein; Psort location: mitochondrial, score: 23 YP_001587303.1 COG: COG4810 Ethanolamine utilization protein; Psort location: cytoplasmic, score: 23 YP_001587304.1 COG: COG4577 Carbon dioxide concentrating mechanism/carboxysome shell protein; Psort location: cytoplasmic, score: 23 YP_001587305.1 KEGG: eci:UTI89_C1819 2.3e-39 rnfC; electron transport complex protein RnfC K03615; COG: COG4656 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC; Psort location: cytoplasmic, score: 23 YP_001587306.1 KEGG: sec:SC2060 9.2e-193 pduQ; propanediol utilization: propanol dehydrogenase K00100; COG: COG1454 Alcohol dehydrogenase, class IV; Psort location: cytoplasmic, score: 23 YP_001587307.1 KEGG: rru:Rru_A0914 4.3e-115 aldehyde dehydrogenase K04021; COG: COG1012 NAD-dependent aldehyde dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001587308.1 KEGG: noc:Noc_0867 3.8e-29 cobalamin adenosyltransferase K00798; COG: COG2096 Uncharacterized conserved protein; Psort location: extracellular, including cell wall, score: 9 YP_001587309.1 COG: COG4576 Carbon dioxide concentrating mechanism/carboxysome shell protein; Psort location: mitochondrial, score: 23 YP_001587310.1 COG: NOG15374 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587311.1 KEGG: dar:Daro_2921 1.1e-42 acetate kinase K00925; COG: COG4869 Propanediol utilization protein; Psort location: cytoplasmic, score: 23 YP_001587312.1 COG: COG4577 Carbon dioxide concentrating mechanism/carboxysome shell protein; Psort location: extracellular, including cell wall, score: 9 YP_001587313.1 COG: COG4577 Carbon dioxide concentrating mechanism/carboxysome shell protein; Psort location: cytoplasmic, score: 23 YP_001587314.1 KEGG: stt:t0833 0.0012 pduD; diol dehydratase medium subunit K06121; COG: NOG12182 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587315.1 COG: NOG06036 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587316.1 KEGG: stm:STM2042 1.4e-86 pduE; Propanediol utilization: dehydratase, small subunit K06122; COG: COG4910 Propanediol dehydratase, small subunit; Psort location: nuclear, score: 23 YP_001587317.1 KEGG: stm:STM2041 1.3e-113 pduD; Propanediol utilization: dehydratase, medium subunit K06121; COG: COG4909 Propanediol dehydratase, large subunit; Psort location: cytoplasmic, score: 23 YP_001587318.1 KEGG: stm:STM2040 7.2e-296 pduC; glycerol dehydratase large subunit K06120; COG: COG4909 Propanediol dehydratase, large subunit; Psort location: cytoplasmic, score: 23 YP_001587319.1 KEGG: ama:AM747 0.0080 nuoK; NADH dehydrogenase chain K K00340; COG: COG4816 Ethanolamine utilization protein; Psort location: endoplasmic reticulum, score: 9 YP_001587320.1 COG: COG4577 Carbon dioxide concentrating mechanism/carboxysome shell protein; Psort location: cytoplasmic, score: 23 YP_001587321.1 KEGG: fal:FRAAL3366 0.00024 putative arsenate reductase (partial match); COG: COG0580 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family); Psort location: plasma membrane, score: 23 YP_001587322.1 KEGG: bsu:BG10166 1.0e-12 adaA; methylphosphotriester-DNA alkyltransferase / transcriptional regulator (AraC family) K00567; COG: COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain; Psort location: nuclear, score: 23 YP_001587323.1 Psort location: mitochondrial, score: 23 YP_001587324.1 responsible for the amidation of carboxylic groups at position A and C of cobyrinic acid or hydrogenobrynic acid YP_001587325.1 CobD; CbiB in Salmonella; converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group YP_001587326.1 catalyzes the interconversion of cobalt-precorrin-8X and cobyrinic acid in the anaerobic biosynthesis of cobalamin YP_001587327.1 Catalyzes the methylation of C-1 in cobalt-precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A YP_001587328.1 catalyzes the methylation of C-5 in cobalt-precorrin-6Y to form cobalt-precorrin-7W-a YP_001587329.1 catalyzes the methylation of either C-15 or C-5 in cobalt-precorrin-6Y to form cobalt-precorrin-7W; decarboxylating YP_001587330.1 KEGG: sty:STY2234 4.8e-132 cbiF; precorrin-4 C11-methyltransferase K03396; COG: COG2875 Precorrin-4 methylase; Psort location: cytoplasmic, score: 23 YP_001587331.1 catalyzes the formation of cobalt-precorrin 4 from cobalt-precorrin 3 YP_001587332.1 KEGG: spt:SPA0844 5.4e-124 cbiH; precorrin-3 C17-methyltransferase K03395; COG: COG1010 Precorrin-3B methylase; Psort location: cytoplasmic, score: 23 YP_001587333.1 CobK/CbiJ; there are 2 pathways for cobalamin (vitamin B12) production, one aerobic (ex. P. denitrificans), the other anaerobic (ex. S. typhimurium); the CobK/CbiJ perform similar reactions in both; the anaerobic pathway includes the use of a chelated cobalt ion in order for ring contraction to occur; CobK thus converts precorrin 6 into dihydro-precorrin 6 while CbiJ converts cobalt-precorrin 6 into cobalt-deihydro-precorrin 6 YP_001587334.1 KEGG: sec:SC2033 4.9e-139 cbiK; synthesis of vitamin B12 adenosyl cobalamide precursor K02190; COG: COG4822 Cobalamin biosynthesis protein CbiK, Co2+ chelatase; Psort location: cytoplasmic, score: 23 YP_001587335.1 catalyzes the formation of precorrin-3A from precorrin-2 YP_001587336.1 catalyzes the ATP-dependent transport of cobalt YP_001587337.1 periplasmic cobalt binding component of the cobalt transport system YP_001587338.1 COG: COG0619 ABC-type cobalt transport system, permease component CbiQ and related transporters; Psort location: endoplasmic reticulum, score: 9 YP_001587339.1 with CbiNQ forms the ABC transporter for cobalt import YP_001587340.1 catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation YP_001587341.1 catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP YP_001587342.1 catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole YP_001587343.1 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole YP_001587344.1 KEGG: eci:UTI89_C2228 9.0e-131 erfK; hypothetical protein K00257; COG: COG1376 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001587345.1 Psort location: cytoplasmic, score: 23 YP_001587346.1 COG: COG0534 Na+-driven multidrug efflux pump; Psort location: plasma membrane, score: 23 YP_001587347.1 Psort location: cytoplasmic, score: 23 YP_001587348.1 Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile YP_001587349.1 Psort location: nuclear, score: 23 YP_001587350.1 Psort location: nuclear, score: 23 YP_001587351.1 COG: COG1666 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001587352.1 COG: NOG07567 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001587353.1 KEGG: fnu:FN1514 1.4e-25 phophatidylinositol-4-phosphate 5-kinase K00889; COG: COG2849 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001587354.1 COG: NOG34225 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001587355.1 COG: COG0582 Integrase; Psort location: cytoplasmic, score: 23 YP_001587356.1 COG: COG0582 Integrase; Psort location: cytoplasmic, score: 23 YP_001587357.1 Psort location: nuclear, score: 23 YP_001587358.1 Psort location: cytoplasmic, score: 23 YP_001587359.1 KEGG: tel:tll1413 3.1e-05 chlD; magnesium-chelatase subunit K03404:K03405; COG: NOG39043 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001587360.1 Psort location: cytoplasmic, score: 23 YP_001587361.1 COG: NOG34171 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587362.1 COG: NOG34190 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587363.1 COG: COG0582 Integrase; Psort location: nuclear, score: 23 YP_001587364.1 Psort location: mitochondrial, score: 23 YP_001587365.1 COG: NOG27689 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587366.1 Psort location: cytoplasmic, score: 23 YP_001587367.1 COG: COG3006 Uncharacterized protein involved in chromosome partitioning; Psort location: cytoplasmic, score: 23 YP_001587368.1 KEGG: shn:Shewana3_2096 2.0e-48 THIoredoxin-disulfide reductase K00384; COG: COG3095 Uncharacterized protein involved in chromosome partitioning; Psort location: cytoplasmic, score: 23 YP_001587369.1 SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects YP_001587370.1 Psort location: cytoplasmic, score: 23 YP_001587371.1 Psort location: nuclear, score: 23 YP_001587372.1 Psort location: cytoplasmic, score: 23 YP_001587373.1 KEGG: oih:OB0759 6.1e-55 ATP-dependent DNA helicase K03657; COG: COG0210 Superfamily I DNA and RNA helicases; Psort location: cytoplasmic, score: 23 YP_001587374.1 COG: NOG16186 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587375.1 COG: COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and THIamine biosynthesis family 2; Psort location: cytoplasmic, score: 23 YP_001587376.1 COG: NOG16470 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001587377.1 COG: NOG27449 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587378.1 COG: COG3423 Predicted transcriptional regulator; Psort location: nuclear, score: 23 YP_001587379.1 Psort location: nuclear, score: 23 YP_001587380.1 Psort location: cytoplasmic, score: 23 YP_001587381.1 COG: COG4683 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001587382.1 COG: NOG21794 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587383.1 Psort location: nuclear, score: 23 YP_001587384.1 COG: COG0582 Integrase; Psort location: cytoplasmic, score: 23 YP_001587385.1 Psort location: cytoplasmic, score: 23 YP_001587386.1 Psort location: cytoplasmic, score: 23 YP_001587387.1 Psort location: nuclear, score: 23 YP_001587388.1 COG: COG0582 Integrase; Psort location: nuclear, score: 23 YP_001587389.1 Psort location: cytoplasmic, score: 23 YP_001587390.1 COG: COG3228 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001587391.1 KEGG: bat:BAS1827 0.0066 homoserine kinase K00872; Psort location: cytoplasmic, score: 23 YP_001587392.1 COG: NOG34277 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001587393.1 binds with UmuC protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization YP_001587394.1 binds processed UmuD protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization YP_001587395.1 Psort location: mitochondrial, score: 23 YP_001587396.1 COG: COG1278 Cold shock proteins; Psort location: cytoplasmic, score: 23 YP_001587397.1 Psort location: cytoplasmic, score: 23 YP_001587398.1 Psort location: cytoplasmic, score: 23 YP_001587399.1 COG: COG3203 Outer membrane protein (porin); Psort location: extracellular, including cell wall, score: 9 YP_001587400.1 Psort location: cytoplasmic, score: 23 YP_001587401.1 Psort location: cytoplasmic, score: 23 YP_001587402.1 Psort location: cytoplasmic, score: 23 YP_001587403.1 COG: NOG20643 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587404.1 COG: COG1418 Predicted HD superfamily hydrolase; Psort location: endoplasmic reticulum, score: 9 YP_001587405.1 KEGG: spt:SPA0878 1.7e-262 dcm; DNA-cytosine methyltransferase K00558; COG: COG0270 Site-specific DNA methylase; Psort location: cytoplasmic, score: 23 YP_001587406.1 KEGG: sec:SC1994 7.9e-84 vsr; DNA mismatch endonuclease, patch repair protein K07458; COG: COG3727 DNA G:T-mismatch repair endonuclease; Psort location: cytoplasmic, score: 23 YP_001587407.1 KEGG: syw:SYNW0942 0.00027 putative phosphatidate cytidylyltransferase K00981; COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001587408.1 COG: COG2354 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001587409.1 COG: COG5475 Uncharacterized small protein; Psort location: cytoplasmic, score: 23 YP_001587410.1 KEGG: vfi:VFA0796 3.9e-26 sensor protein; COG: COG2199 FOG: GGDEF domain; Psort location: endoplasmic reticulum, score: 9 YP_001587411.1 catalyzes the hydrolysis of mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate YP_001587412.1 COG: NOG14111 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587413.1 COG: NOG14105 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587414.1 COG: COG2771 DNA-binding HTH domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001587415.1 FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus YP_001587416.1 with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus YP_001587417.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus YP_001587418.1 with FlhA, FlhB, FliP, FliQ and FliR is one of the membrane components of the flagellar export apparatus YP_001587419.1 One of three proteins involved in switching the direction of the flagellar rotation YP_001587420.1 with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation YP_001587421.1 interacts with cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring YP_001587422.1 KEGG: bxe:Bxe_A1062 0.00040 ribonuclease E and G; COG: COG3144 Flagellar hook-length control protein; Psort location: nuclear, score: 23 YP_001587423.1 rod/hook and filament chaperone YP_001587424.1 involved in type III protein export during flagellum assembly YP_001587425.1 binds to and inhibits the function of flagella specific ATPase FliI YP_001587426.1 One of three proteins involved in switching the direction of the flagellar rotation YP_001587427.1 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod YP_001587428.1 Psort location: cytoplasmic, score: 23 YP_001587429.1 forms a junction between the M-ring and FlgB during flagella biosynthesis YP_001587430.1 COG: NOG29680 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001587431.1 Psort location: mitochondrial, score: 23 YP_001587432.1 COG: COG0425 Predicted redox protein, regulator of disulfide bond formation; Psort location: nuclear, score: 23 YP_001587433.1 COG: COG2391 Predicted transporter component; Psort location: endoplasmic reticulum, score: 9 YP_001587434.1 COG: NOG09020 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001587435.1 converts 1,4-alpha-D-glucans to maltodextrin YP_001587436.1 binds flagellar cap subunits (FliD) and seems to prevents their oligomerization prior to its translocation through the flagellum-specific type III export pathway; acts as a repressor of flagellar class 2 operons by preventing FlhD2C2 to bind the promoter and inhibiting the FlhD2C2-dependent transcription; member of the type III cytoplasmic chaperone family YP_001587437.1 flagellin specific chaperone YP_001587438.1 involved in flagellin assembly YP_001587439.1 Psort location: nuclear, score: 23 YP_001587440.1 Psort location: nuclear, score: 23 YP_001587441.1 structural flagella protein; individual Salmonella serotypes usually alternate between the production of 2 antigenic forms of flagella, termed phase 1 and phase 2, each specified by separate structural genes YP_001587442.1 COG: NOG18465 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587443.1 Psort location: cytoplasmic, score: 23 YP_001587444.1 KEGG: nwi:Nwi_0782 3.1e-07 integrase, catalytic region K00986; COG: COG2801 Transposase and inactivated derivatives; Psort location: nuclear, score: 23 YP_001587445.1 KEGG: stm:STM1958 3.7e-212 fliB; N-methylation of lysine residues in flagellin K00599; COG: NOG18602 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587446.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes YP_001587447.1 expression activator of the class 2 type of flagellar operons, essential to achieve maximal cell motility; activator of type 1 fimbrial gene expression; cell density-responsive regulator; FliZ in Salmonella typhimurium induces HilA, an activator of invasion genes necessary to achieve full virulence YP_001587448.1 Psort location: nuclear, score: 23 YP_001587449.1 KEGG: eci:UTI89_C2121 7.9e-116 fliY; cystine-binding periplasmic protein precursor K02030:K02424; COG: COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; Psort location: cytoplasmic, score: 23 YP_001587450.1 Psort location: mitochondrial, score: 23 YP_001587451.1 catalyzes the formation of pyruvate from D-cysteine YP_001587452.1 KEGG: hpa:HPAG1_0922 2.2e-40 amino acid ABC transporter, permease protein; COG: COG0765 ABC-type amino acid transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001587453.1 KEGG: spt:SPA0918 8.3e-128 yecC; putative ABC transport ATP-binding protein K02028; COG: COG1126 ABC-type polar amino acid transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001587454.1 regulates genes involved in cell division YP_001587455.1 COG: NOG13894 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001587456.1 COG: NOG33125 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587457.1 in Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate virulence gene expression also via the Csr system YP_001587458.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_001587459.1 KEGG: stt:t0931 2.8e-95 pgsA; phosphotidylglycerophosphate synthetase K00995; COG: COG0558 Phosphatidylglycerophosphate synthase; Psort location: endoplasmic reticulum, score: 9 YP_001587460.1 Psort location: nuclear, score: 23 YP_001587461.1 COG: NOG33408 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001587462.1 KEGG: rba:RB11119 2.8e-05 pipeptidyl-peptidase VI; COG: COG0791 Cell wall-associated hydrolases (invasion-associated proteins); Psort location: extracellular, including cell wall, score: 9 YP_001587463.1 KEGG: ath:At5g35790 0.0025 MWP19.3; glucose-6-phosphate dehydrogenase K00036; COG: NOG33353 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001587464.1 COG: COG3318 Predicted metal-binding protein related to the C-terminal domain of SecA; Psort location: cytoplasmic, score: 23 YP_001587465.1 COG: COG0814 Amino acid permeases; Psort location: plasma membrane, score: 23 YP_001587466.1 COG: NOG14112 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587467.1 cytoplasmic iron storage protein YP_001587468.1 Psort location: cytoplasmic, score: 23 YP_001587469.1 COG: NOG11332 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001587470.1 KEGG: stm:STM1933 2.2e-111 hypothetical protein K01806; COG: COG0698 Ribose 5-phosphate isomerase RpiB; Psort location: cytoplasmic, score: 23 YP_001587471.1 KEGG: cel:D1037.3 0.0088 ferritin; D1037.3 K00522; COG: COG1528 Ferritin-like protein; Psort location: cytoplasmic, score: 23 YP_001587472.1 Psort location: nuclear, score: 23 YP_001587473.1 KEGG: lic:LIC11685 2.3e-15 4-methyl-5(b-hydroxyethyl)-THIazole monophosphate biosynthesis K03152; COG: COG0693 Putative intracellular protease/amidase; Psort location: extracellular, including cell wall, score: 23 YP_001587474.1 biosynthetic; catalyzes the formation of trehalose and phosphate from trehalose-6-phosphate; expression is increased under osmotic stress and induced during the transition to stationary phase and by decreased temperature YP_001587475.1 KEGG: stm:STM1928 1.1e-258 otsA; trehalose-6-phosphate synthase K00697; COG: COG0380 Trehalose-6-phosphate synthase; Psort location: cytoplasmic, score: 23 YP_001587476.1 ppGpp-dependent; membrane-associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress YP_001587477.1 Psort location: cytoplasmic, score: 23 YP_001587478.1 Psort location: cytoplasmic, score: 23 YP_001587479.1 with FlhC is involved in the activation of class 2 flagellar genes and is involved in the regulation of a number of other genetic systems YP_001587480.1 With FlhD is involved in the activation of class 2 flagellar genes and as well as a number of other genetic systems YP_001587481.1 Psort location: mitochondrial, score: 23 YP_001587482.1 With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine YP_001587483.1 with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine YP_001587484.1 chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY; sensory histidine kinase/signal sensing protein; CheA is the histidine kinase component YP_001587485.1 KEGG: eci:UTI89_C2090 3.0e-75 cheW; CheW positive regulator of CheA protein activity K03408; COG: COG0835 Chemotaxis signal transduction protein; Psort location: cytoplasmic, score: 23 YP_001587486.1 KEGG: vpa:VPA0675 4.6e-10 torS; sensor protein TorS K07647; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001587487.1 methylates the MCP YP_001587488.1 regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins YP_001587489.1 chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble YP_001587490.1 cytosolic phosphatase which functions in the chemotaxis signal transduction complex by controlling the level of phosphorylated CheY through dephosphorylation YP_001587491.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export YP_001587492.1 membrane protein involved in the flagellar export apparatus YP_001587493.1 COG: NOG12148 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001587494.1 Psort location: mitochondrial, score: 23 YP_001587495.1 COG: COG4225 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins; Psort location: cytoplasmic, score: 23 YP_001587496.1 KEGG: eci:UTI89_C0637 2.4e-194 mrdA; cell elongation, e phase; peptidoglycan synthetase; penicillin-binding protein 2 K05515; COG: COG0768 Cell division protein FtsI/penicillin-binding protein 2; Psort location: cytoplasmic, score: 23 YP_001587497.1 Psort location: mitochondrial, score: 23 YP_001587498.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_001587499.1 Psort location: mitochondrial, score: 23 YP_001587500.1 COG: COG3102 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001587501.1 COG: COG3142 Uncharacterized protein involved in copper resistance; Psort location: cytoplasmic, score: 23 YP_001587502.1 KEGG: eci:UTI89_C2075 1.8e-166 yecP; hypothetical protein K00599; COG: COG0500 SAM-dependent methyltransferases; Psort location: cytoplasmic, score: 23 YP_001587503.1 KEGG: eci:UTI89_C2074 1.3e-122 yecO; hypothetical protein K00559; COG: COG0500 SAM-dependent methyltransferases; Psort location: cytoplasmic, score: 23 YP_001587504.1 KEGG: hsa:4056 3.4e-05 LTC4S; leukotriene C4 synthase K00807; COG: COG3788 Uncharacterized relative of glutaTHIone S-transferase, MAPEG superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001587505.1 COG: COG1801 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001587506.1 KEGG: eci:UTI89_C2071 8.4e-80 yecD; hypothetical protein; COG: COG1335 Amidases related to nicotinamidase; Psort location: endoplasmic reticulum, score: 9 YP_001587507.1 Psort location: mitochondrial, score: 23 YP_001587508.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_001587509.1 KEGG: sec:SC1908 1.3e-65 ntpA; dATP pyrophosphohydrolase K08310; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: cytoplasmic, score: 23 YP_001587510.1 KEGG: eci:UTI89_C2068 4.6e-127 yebC; hypothetical protein K00975; COG: COG0217 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001587511.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity YP_001587512.1 KEGG: mst:Msp_0343 9.9e-21 pstS; PstS K02040; COG: COG0226 ABC-type phosphate transport system, periplasmic component; Psort location: endoplasmic reticulum, score: 9 YP_001587513.1 COG: NOG06204 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587514.1 COG: NOG26311 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001587515.1 Psort location: endoplasmic reticulum, score: 9 YP_001587516.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_001587517.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_001587518.1 involved in transport of zinc(II) with ZnuA and C YP_001587519.1 KEGG: pen:PSEEN0071 9.5e-56 znuC; zinc ABC transporter, ATP-binding protein; COG: COG1121 ABC-type Mn/Zn transport systems, ATPase component; Psort location: cytoplasmic, score: 23 YP_001587520.1 involved in transport of zinc(II) with ZnuA and C YP_001587521.1 KEGG: stm:STM1890 5.7e-232 yebA; putative peptidase; COG: COG0739 Membrane proteins related to metalloendopeptidases; Psort location: mitochondrial, score: 23 YP_001587522.1 Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA YP_001587523.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_001587524.1 Represses the expression of the zwf, eda, glp and gap YP_001587525.1 Psort location: cytoplasmic, score: 23 YP_001587526.1 Psort location: cytoplasmic, score: 23 YP_001587527.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_001587528.1 Psort location: mitochondrial, score: 23 YP_001587529.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate YP_001587530.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate YP_001587531.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis YP_001587532.1 COG: COG3141 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001587533.1 secreted protein; unknown function YP_001587534.1 COG: COG2979 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001587535.1 PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues YP_001587536.1 3'-5' exonuclease activity on single or double-strand DNA YP_001587537.1 KEGG: psp:PSPPH_2956 0.00041 hydrolase, carbon-nitrogen family K01950; COG: COG0388 Predicted amidohydrolase; Psort location: cytoplasmic, score: 23 YP_001587538.1 KEGG: spt:SPA0993 2.7e-35 holE; DNA polymerase III, theta subunit K02345; COG: NOG13893 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587539.1 COG: COG2372 Uncharacterized protein, homolog of Cu resistance protein CopC; Psort location: extracellular, including cell wall, score: 9 YP_001587540.1 COG: COG1276 Putative copper export protein; Psort location: plasma membrane, score: 23 YP_001587541.1 COG: NOG09766 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001587542.1 COG: COG0582 Integrase; Psort location: cytoplasmic, score: 23 YP_001587543.1 Psort location: nuclear, score: 23 YP_001587544.1 Psort location: nuclear, score: 23 YP_001587545.1 COG: COG5525 Bacteriophage tail assembly protein; Psort location: nuclear, score: 23 YP_001587546.1 COG: NOG18514 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587547.1 Psort location: extracellular, including cell wall, score: 9 YP_001587548.1 Psort location: cytoplasmic, score: 23 YP_001587549.1 KEGG: ypn:YPN_0750 1.9e-82 extracellular solute-binding protein K01713; COG: COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; Psort location: extracellular, including cell wall, score: 9 YP_001587550.1 Psort location: mitochondrial, score: 23 YP_001587551.1 Psort location: nuclear, score: 23 YP_001587552.1 Psort location: nuclear, score: 23 YP_001587553.1 Psort location: nuclear, score: 23 YP_001587554.1 COG: COG0582 Integrase; Psort location: mitochondrial, score: 23 YP_001587555.1 KEGG: ece:Z2409 3.2e-87 recE; putative exodeoxyribonuclease VIII of prophage CP-933R K01146; COG: NOG06785 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001587556.1 COG: COG3179 Predicted chitinase; Psort location: cytoplasmic, score: 23 YP_001587557.1 KEGG: stm:STM0908 0.0015 Fels-1 prophage K01423; COG: NOG11447 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001587558.1 Psort location: cytoplasmic, score: 23 YP_001587559.1 Psort location: endoplasmic reticulum, score: 9 YP_001587560.1 Psort location: nuclear, score: 23 YP_001587561.1 COG: NOG34132 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587562.1 COG: COG5525 Bacteriophage tail assembly protein; Psort location: nuclear, score: 23 YP_001587563.1 COG: COG5301 Phage-related tail fibre protein; Psort location: cytoplasmic, score: 23 YP_001587564.1 Psort location: nuclear, score: 23 YP_001587565.1 Psort location: cytoplasmic, score: 23 YP_001587566.1 Psort location: cytoplasmic, score: 23 YP_001587567.1 KEGG: ecj:JW3469 2.5e-05 arsB; arsenite/antimonite transporter K03893; Psort location: cytoplasmic, score: 23 YP_001587568.1 Psort location: cytoplasmic, score: 23 YP_001587569.1 Psort location: cytoplasmic, score: 23 YP_001587570.1 Psort location: cytoplasmic, score: 23 YP_001587571.1 Psort location: cytoplasmic, score: 23 YP_001587572.1 COG: COG1495 Disulfide bond formation protein DsbB; Psort location: endoplasmic reticulum, score: 9 YP_001587573.1 Psort location: nuclear, score: 23 YP_001587574.1 COG: NOG23006 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001587575.1 COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: plasma membrane, score: 23 YP_001587576.1 Psort location: mitochondrial, score: 23 YP_001587577.1 Psort location: cytoplasmic, score: 23 YP_001587578.1 Psort location: mitochondrial, score: 23 YP_001587579.1 COG: COG0582 Integrase; Psort location: mitochondrial, score: 23 YP_001587580.1 Psort location: cytoplasmic, score: 23 YP_001587581.1 Psort location: cytoplasmic, score: 23 YP_001587582.1 Psort location: cytoplasmic, score: 23 YP_001587583.1 COG: NOG31307 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001587584.1 Psort location: nuclear, score: 23 YP_001587585.1 KEGG: shn:Shewana3_0771 1.1e-06 pantoate--beta-alanine ligase K01918; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001587586.1 Psort location: mitochondrial, score: 23 YP_001587587.1 COG: NOG23759 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001587588.1 COG: COG5562 Phage envelope protein; Psort location: cytoplasmic, score: 23 YP_001587589.1 Psort location: endoplasmic reticulum, score: 9 YP_001587590.1 Psort location: mitochondrial, score: 23 YP_001587591.1 Psort location: endoplasmic reticulum, score: 9 YP_001587592.1 COG: NOG18552 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001587593.1 Psort location: mitochondrial, score: 23 YP_001587594.1 COG: NOG32758 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001587595.1 Psort location: mitochondrial, score: 23 YP_001587596.1 Plays a key role in signaling protein misfolding via the cpxR/cpxA transducing system; modulates the phosphorylated status of many phosphoproteins YP_001587597.1 COG: NOG12164 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001587598.1 COG: NOG13883 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587599.1 Psort location: cytoplasmic, score: 23 YP_001587600.1 in Escherichia coli this enzyme specifically methylates C1407 of the 16S rRNA YP_001587601.1 COG: COG3008 Paraquat-inducible protein B; Psort location: cytoplasmic, score: 23 YP_001587602.1 COG: COG2995 Uncharacterized paraquat-inducible protein A; Psort location: plasma membrane, score: 23 YP_001587603.1 KEGG: gbe:GbCGDNIH1_0602 0.0011 phosphoenolpyruvate-protein phosphotransferase; COG: COG1956 GAF domain-containing protein; Psort location: cytoplasmic, score: 23 YP_001587604.1 affects solute and DNA transport through an unknown mechanism YP_001587605.1 Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3 YP_001587606.1 Psort location: nuclear, score: 23 YP_001587607.1 KEGG: stm:STM1844 4.3e-131 htpX; heat shock protein, integral membrane protein K03799; COG: COG0501 Zn-dependent protease with chaperone function; Psort location: endoplasmic reticulum, score: 9 YP_001587608.1 KEGG: sgl:SG1466 5.9e-07 deTHIobiotin synthase K01935; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001587609.1 Psort location: cytoplasmic, score: 23 YP_001587610.1 COG: COG1414 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001587611.1 COG: NOG13884 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001587612.1 COG: NOG18120 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001587613.1 COG: NOG11327 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001587614.1 Psort location: mitochondrial, score: 23 YP_001587615.1 Psort location: cytoplasmic, score: 23 YP_001587616.1 Psort location: mitochondrial, score: 23 YP_001587617.1 COG: COG1278 Cold shock proteins; Psort location: cytoplasmic, score: 23 YP_001587618.1 Psort location: cytoplasmic, score: 23 YP_001587619.1 KEGG: ecc:c0102 1.2e-199 ftsI; peptidoglycan synthetase ftsI precursor K03587; COG: COG0768 Cell division protein FtsI/penicillin-binding protein 2; Psort location: endoplasmic reticulum, score: 9 YP_001587620.1 methylates the guanosine in position 745 of 23S rRNA; required for translation and cell growth YP_001587621.1 COG: COG1971 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001587622.1 COG: COG4811 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001587623.1 hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel YP_001587624.1 KEGG: eci:UTI89_C2015 4.0e-128 manY; PTS enzyme IIC, mannose-specific K02795; COG: COG3715 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC; Psort location: endoplasmic reticulum, score: 9 YP_001587625.1 KEGG: stt:t1048 7.6e-166 manX; mannose-specific IIAB component of PTS system K02793:K02794; COG: COG2893 Phosphotransferase system, mannose/fructose-specific component IIA; Psort location: cytoplasmic, score: 23 YP_001587626.1 Psort location: cytoplasmic, score: 23 YP_001587627.1 KEGG: eci:UTI89_C0656 3.5e-25 ybeX; putative transport protein K06189; COG: COG1253 Hemolysins and related proteins containing CBS domains; Psort location: plasma membrane, score: 23 YP_001587628.1 KEGG: eci:UTI89_C1702 1.4e-29 hypothetical protein; COG: COG2200 FOG: EAL domain; Psort location: endoplasmic reticulum, score: 9 YP_001587629.1 KEGG: sty:STY1956 2.6e-243 sdaA; L-serine deaminase 1 K01752; COG: COG1760 L-serine deaminase; Psort location: cytoplasmic, score: 23 YP_001587630.1 KEGG: gbe:GbCGDNIH1_1634 3.7e-31 coA pyrophosphatase K01529; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: cytoplasmic, score: 23 YP_001587631.1 KEGG: stm:STM1824 1.9e-247 pabB; p-aminobenzoate synthetase, component I K01665; COG: COG0147 Anthranilate/para-aminobenzoate synthases component I; Psort location: cytoplasmic, score: 23 YP_001587632.1 COG: COG3140 Uncharacterized protein conserved in bacteria; Psort location: cytoskeletal, score: 9 YP_001587633.1 KEGG: mxa:MXAN_0920 1.6e-05 2-aminomuconate deaminase; COG: COG0251 Putative translation initiation inhibitor, yjgF family; Psort location: cytoskeletal, score: 9 YP_001587634.1 KEGG: sty:STY1951 0. putative ATP-dependent helicase K03722; COG: COG1199 Rad3-related DNA helicases; Psort location: cytoplasmic, score: 23 YP_001587635.1 KEGG: ecp:ECP_1750 7.1e-83 hypothetical protease YeaZ K01423; COG: COG1214 Inactive homolog of metal-dependent proteases, putative molecular chaperone; Psort location: cytoplasmic, score: 23 YP_001587636.1 COG: COG3065 Starvation-inducible outer membrane lipoprotein; Psort location: extracellular, including cell wall, score: 9 YP_001587637.1 Psort location: cytoplasmic, score: 23 YP_001587638.1 Activates fatty acids by binding to coenzyme A YP_001587639.1 KEGG: sec:SC1810 2.2e-198 rnd; RNase D, processes tRNA precursor K03684; COG: COG0349 Ribonuclease D; Psort location: cytoplasmic, score: 23 YP_001587640.1 works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell YP_001587641.1 ATPase; with MinC inhibits cell division by blocking formation of the polar Z ring septums YP_001587642.1 blocks the formation of polar Z-ring septums YP_001587643.1 COG: COG3100 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001587644.1 KEGG: bpm:BURPS1710b_A0012 7.5e-40 fumarylacetoacetate (FAA) hydrolase K01557; COG: COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway); Psort location: cytoplasmic, score: 23 YP_001587645.1 COG: COG2983 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001587646.1 COG: NOG32497 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001587647.1 Psort location: mitochondrial, score: 23 YP_001587648.1 COG: NOG18116 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587649.1 COG: COG3615 Uncharacterized protein/domain, possibly involved in tellurite resistance; Psort location: cytoplasmic, score: 23 YP_001587650.1 disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein YP_001587651.1 involved in regulation of intracellular pH under alkaline conditions YP_001587652.1 Psort location: endoplasmic reticulum, score: 9 YP_001587653.1 Multifunctional regulator of fatty acid metabolism YP_001587654.1 COG: COG2719 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001587655.1 Psort location: cytoplasmic, score: 23 YP_001587656.1 catalyzes the oxidative deamination of D-amino acids YP_001587657.1 catabolic enzyme, converts L-alanine to D-alanine which is then oxidized to pyruvate by dadA YP_001587658.1 the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli YP_001587659.1 catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine YP_001587660.1 KEGG: stm:STM1799 4.9e-107 emtA; membrane-bound lytic murein transglycosylase E K08308; COG: COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains); Psort location: extracellular, including cell wall, score: 9 YP_001587661.1 COG: COG5581 Predicted glycosyltransferase; Psort location: cytoplasmic, score: 23 YP_001587662.1 KEGG: cjk:jk1171 0.00057 cdsA; phosphatidate cytidylyltransferase K00981; COG: COG2261 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001587663.1 periplasmic; catalyzes the hydrolysis of trehalose to glucose which can then be imported into the cell YP_001587664.1 Psort location: nuclear, score: 23 YP_001587665.1 KEGG: stm:STM1795 2.9e-237 putative glutamic dehyrogenase-like protein K00261; COG: COG0334 Glutamate dehydrogenase/leucine dehydrogenase; Psort location: cytoplasmic, score: 23 YP_001587666.1 Psort location: mitochondrial, score: 23 YP_001587667.1 KEGG: stt:t1083 6.2e-203 appB; probable cytochrome oxidase subunit II K00426; COG: COG1294 Cytochrome bd-type quinol oxidase, subunit 2; Psort location: plasma membrane, score: 23 YP_001587668.1 KEGG: spt:SPA1081 2.7e-280 appC; probable THIrd cytochrome oxidase, subunit I K00425; COG: COG1271 Cytochrome bd-type quinol oxidase, subunit 1; Psort location: endoplasmic reticulum, score: 9 YP_001587669.1 KEGG: eci:UTI89_C1045 5.0e-114 hyaF; hydrogenase-1 operon protein HyaF K03618; COG: NOG06279 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587670.1 involved in processing hydrogenase proteins HyaA and HyaB YP_001587671.1 HyaD; endopeptidase involved in the cleavage of the C-terminus end of HyaB (the large subunit of hydrogenase 1) YP_001587672.1 KEGG: eci:UTI89_C1042 1.8e-109 hyaC; probable Ni/Fe-hydrogenase 1 B-type cytochrome subunit K03620; COG: COG1969 Ni,Fe-hydrogenase I cytochrome b subunit; Psort location: endoplasmic reticulum, score: 9 YP_001587673.1 involved in hydrogen cycling during fermentative growth YP_001587674.1 KEGG: stm:STM1786 7.4e-207 hydrogenase small chain K06282; COG: COG1740 Ni,Fe-hydrogenase I small subunit; Psort location: mitochondrial, score: 23 YP_001587675.1 Psort location: nuclear, score: 23 YP_001587676.1 Psort location: endoplasmic reticulum, score: 9 YP_001587677.1 COG: NOG25521 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587678.1 Psort location: cytoplasmic, score: 23 YP_001587679.1 Psort location: endoplasmic reticulum, score: 9 YP_001587680.1 Psort location: endoplasmic reticulum, score: 9 YP_001587681.1 Psort location: cytoplasmic, score: 23 YP_001587682.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_001587683.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_001587684.1 YchH; transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria; ychH presents a class II promoter to bind CRP; unknown function YP_001587685.1 putative role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport YP_001587686.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_001587687.1 Psort location: mitochondrial, score: 23 YP_001587688.1 Psort location: nuclear, score: 23 YP_001587689.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis YP_001587690.1 Incorporates lipoproteins in the outer membrane after they are released by the LolA protein YP_001587691.1 Psort location: nuclear, score: 23 YP_001587692.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins YP_001587693.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_001587694.1 HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB YP_001587695.1 COG: COG3094 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001587696.1 COG: COG2912 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001587697.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis YP_001587698.1 COG: COG0387 Ca2+/H+ antiporter; Psort location: plasma membrane, score: 23 YP_001587699.1 Psort location: cytoplasmic, score: 23 YP_001587700.1 in Escherichia coli this protein putatively regulates the sodium/proton (also pH-independent calcium/proton) antiporter chaA; has weak affinity for calcium and magnesium ions YP_001587701.1 COG: COG1553 Uncharacterized conserved protein involved in intracellular sulfur reduction; Psort location: cytoplasmic, score: 23 YP_001587702.1 Psort location: cytoplasmic, score: 23 YP_001587703.1 COG: NOG06760 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587704.1 two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase YP_001587705.1 KEGG: sec:SC1760 0. narX; sensory histidine kinase in two component regulatory system with NarL, senses nitrate/nitrite, regulates anaerobic respiration and fermentation K07673; COG: COG3850 Signal transduction histidine kinase, nitrate/nitrite-specific; Psort location: endoplasmic reticulum, score: 9 YP_001587706.1 Psort location: mitochondrial, score: 23 YP_001587707.1 COG: COG2223 Nitrate/nitrite transporter; Psort location: plasma membrane, score: 23 YP_001587708.1 Psort location: cytoplasmic, score: 23 YP_001587709.1 KEGG: stm:STM1764 0. narG; nitrate reductase alpha chain K00370; COG: COG5013 Nitrate reductase alpha subunit; Psort location: cytoplasmic, score: 23 YP_001587710.1 KEGG: stt:t1672 1.9e-288 narH; respiratory nitrate reductase 1 beta chain K00371; COG: COG1140 Nitrate reductase beta subunit; Psort location: cytoplasmic, score: 23 YP_001587711.1 KEGG: stm:STM1762 4.0e-121 narJ; nitrate reductase delta chain K00373; COG: COG2180 Nitrate reductase delta subunit; Psort location: cytoplasmic, score: 23 YP_001587712.1 KEGG: stm:STM1761 2.5e-119 narI; nitrate reductase gamma chain K00374; COG: COG2181 Nitrate reductase gamma subunit; Psort location: plasma membrane, score: 23 YP_001587713.1 Psort location: nuclear, score: 23 YP_001587714.1 KEGG: cch:Cag_1938 1.5e-64 Sel1-like repeat; COG: COG0790 FOG: TPR repeat, SEL1 subfamily; Psort location: mitochondrial, score: 23 YP_001587715.1 KEGG: stm:STM1756 4.1e-126 purU; formyltetrahydrofolate deformylase K01433; COG: COG0788 Formyltetrahydrofolate hydrolase; Psort location: cytoplasmic, score: 23 YP_001587716.1 Psort location: cytoplasmic, score: 23 YP_001587717.1 KEGG: pen:PSEEN4477 0.00064 secA; preprotein translocase SecA subunit; COG: COG3012 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001587718.1 KEGG: eci:UTI89_C1430 1.9e-137 ychK; hypothetical protein; COG: COG1752 Predicted esterase of the alpha-beta hydrolase superfamily; Psort location: cytoplasmic, score: 23 YP_001587719.1 KEGG: eci:UTI89_C1431 1.5e-160 rssB; RssB/Hnr protein K02485; COG: COG0784 FOG: CheY-like receiver; Psort location: cytoplasmic, score: 23 YP_001587720.1 together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose YP_001587721.1 COG: COG2916 DNA-binding protein H-NS; Psort location: nuclear, score: 23 YP_001587722.1 Psort location: nuclear, score: 23 YP_001587723.1 KEGG: stt:t1661 2.1e-90 tdk; thymidine kinase K00857; COG: COG1435 Thymidine kinase; Psort location: cytoskeletal, score: 9 YP_001587724.1 KEGG: stm:STM1749 0. adhE; alcohol dehydrogenase / acetaldehyde dehydrogenase K00001:K04072; COG: COG1012 NAD-dependent aldehyde dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001587725.1 COG: COG2095 Multiple antibiotic transporter; Psort location: plasma membrane, score: 23 YP_001587726.1 Psort location: mitochondrial, score: 23 YP_001587727.1 KEGG: rpd:RPD_2839 0.0048 LexA repressor K01356; Psort location: nuclear, score: 23 YP_001587728.1 KEGG: shn:Shewana3_2650 6.1e-23 acetate kinase K00925; COG: COG4166 ABC-type oligopeptide transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001587729.1 KEGG: rha:RHA1_ro09047 3.0e-43 ABC peptide transporter, permease component K02033; COG: COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001587730.1 KEGG: baa:BA_0884 0.0024 binding-protein-dependent transport systems inner membrane component K00294; COG: COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001587731.1 KEGG: rru:Rru_A0589 5.7e-97 oligopeptide/dipeptide ABC transporter, ATP-binding protein-like K02031; COG: COG0444 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001587732.1 KEGG: bur:Bcep18194_B0119 2.8e-95 oligopeptide/dipeptide ABC transporter, ATPase subunit K02032; COG: COG4608 ABC-type oligopeptide transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001587733.1 COG: COG1226 Kef-type K+ transport systems, predicted NAD-binding component; Psort location: endoplasmic reticulum, score: 9 YP_001587734.1 highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein YP_001587735.1 catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol) YP_001587736.1 Psort location: nuclear, score: 23 YP_001587737.1 unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity YP_001587738.1 membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins YP_001587739.1 YciA; hydrolase that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA; member of the the acyl coenzyme A hydrolase family of proteins YP_001587740.1 Involved in cell division; probably involved in intracellular septation YP_001587741.1 COG: NOG06197 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001587742.1 COG: COG0727 Predicted Fe-S-cluster oxidoreductase; Psort location: nuclear, score: 23 YP_001587743.1 receptor for colicin S4 YP_001587744.1 KEGG: mfa:Mfla_1436 1.8e-109 catalase K00429; COG: COG3546 Mn-containing catalase; Psort location: mitochondrial, score: 23 YP_001587745.1 KEGG: rpe:RPE_3645 6.0e-05 catalase K00429; COG: COG3685 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001587746.1 KEGG: rpe:RPE_3645 4.6e-25 catalase K00429; COG: COG3685 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001587747.1 Psort location: cytoplasmic, score: 23 YP_001587749.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis YP_001587750.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_001587751.1 monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate YP_001587752.1 bifunctional anthranilate synthase II/anthranilate phosphoribosyltransferase; TrpD; forms a heterotetramer with Trp E and the complex catalyzes the formation of anthranilate from chorismate and glutamine; also catalyzes the formation of N-(5-phospho-D-ribosyl)-anthranilate from athranilate and 5-phospho-alpha-D-ribose 1-diphosphate; functions in tryptophan biosynthesis YP_001587753.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine YP_001587754.1 KEGG: reh:H16_A1200 1.5e-41 predicted metal-dependent phosphoesterase (PHP family); COG: COG0613 Predicted metal-dependent phosphoesterases (PHP family); Psort location: cytoplasmic, score: 23 YP_001587755.1 COG: COG0009 Putative translation factor (SUA5); Psort location: cytoplasmic, score: 23 YP_001587756.1 catalyzes the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA YP_001587757.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide YP_001587758.1 KEGG: ecc:c1736 2.2e-120 yciK; short chain dehydrogenase; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001587759.1 Psort location: nuclear, score: 23 YP_001587760.1 SohB; periplasmic protein; member of the peptidase S49 family YP_001587761.1 COG: NOG13548 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587762.1 Psort location: cytoplasmic, score: 23 YP_001587763.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity YP_001587764.1 Psort location: mitochondrial, score: 23 YP_001587765.1 KEGG: shn:Shewana3_3435 1.8e-08 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001587766.1 Psort location: nuclear, score: 23 YP_001587767.1 COG: NOG13876 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001587768.1 Psort location: nuclear, score: 23 YP_001587769.1 Psort location: cytoplasmic, score: 23 YP_001587770.1 Catalyzes the conversion of citrate to isocitrate YP_001587771.1 catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate YP_001587772.1 KEGG: sty:STY1341 1.6e-140 pgpB; phosphatidylglycerophosphatase B K01096; COG: COG0671 Membrane-associated phospholipid phosphatase; Psort location: endoplasmic reticulum, score: 9 YP_001587773.1 COG: COG3771 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001587774.1 KEGG: azo:azo1075 4.3e-60 conserved hypothetical transferase protein; COG: COG2956 Predicted N-acetylglucosaminyl transferase; Psort location: cytoplasmic, score: 23 YP_001587775.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase YP_001587776.1 COG: COG0023 Translation initiation factor 1 (eIF-1/SUI1) and related proteins; Psort location: cytoplasmic, score: 23 YP_001587777.1 COG: NOG17005 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001587778.1 Psort location: cytoplasmic, score: 23 YP_001587779.1 COG: COG1349 Transcriptional regulators of sugar metabolism; Psort location: cytoskeletal, score: 9 YP_001587780.1 Psort location: cytoplasmic, score: 23 YP_001587781.1 Psort location: nuclear, score: 23 YP_001587782.1 c-di-GMP phosphodiesterase; probably degrades signalling molecule c-di-GMP YP_001587783.1 Psort location: cytoplasmic, score: 23 YP_001587784.1 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction YP_001587785.1 COG: COG2128 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001587786.1 Psort location: nuclear, score: 23 YP_001587787.1 Catalyzes a key regulatory step in fatty acid biosynthesis YP_001587788.1 Psort location: nuclear, score: 23 YP_001587789.1 COG: NOG18521 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587790.1 Psort location: nuclear, score: 23 YP_001587791.1 Psort location: mitochondrial, score: 23 YP_001587792.1 KEGG: hpa:HPAG1_0304 4.9e-52 dipeptide ABC transporter K00927; COG: COG4167 ABC-type antimicrobial peptide transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001587793.1 KEGG: ret:RHE_CH00739 5.0e-66 dppDch1, dppFch1; dipeptide ABC transporter, ATP-binding protein K02031; COG: COG4170 ABC-type antimicrobial peptide transport system, ATPase component; Psort location: nuclear, score: 23 YP_001587794.1 KEGG: lwe:lwe0999 0.00037 gbuB; glycine betaine/L-proline ABC transporter, permease protein; COG: COG4171 ABC-type antimicrobial peptide transport system, permease component; Psort location: endoplasmic reticulum, score: 23 YP_001587795.1 KEGG: syf:Synpcc7942_2454 9.0e-28 adenine phosphoribosyltransferase K00759; COG: COG4168 ABC-type antimicrobial peptide transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001587796.1 KEGG: shn:Shewana3_2650 7.1e-123 acetate kinase K00925; COG: COG4166 ABC-type oligopeptide transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001587797.1 transcriptional activator for pspABCE which are induced in response to phage proteins, membrane altering stresses, and impaired proton expor YP_001587798.1 involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF YP_001587799.1 acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding YP_001587800.1 with PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock YP_001587801.1 COG: NOG14121 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587802.1 rhodanese; catalyzes the formation of thiocyanate from thiosulfate and hydrogen cyanide YP_001587803.1 KEGG: sdy:SDY_1399 2.6e-243 ycjX; putative YcjX; COG: COG3106 Predicted ATPase; Psort location: cytoplasmic, score: 23 YP_001587804.1 COG: COG3768 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 23 YP_001587805.1 Psort location: extracellular, including cell wall, score: 9 YP_001587806.1 regulates genes involved in the biosynthesis and transport of aromatic amino acids YP_001587807.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein YP_001587808.1 KEGG: sdy:SDY_1403 1.0e-145 ycjG; putative muconate cycloisomerase I; COG: COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily; Psort location: cytoplasmic, score: 23 YP_001587809.1 COG: COG2866 Predicted carboxypeptidase; Psort location: cytoplasmic, score: 23 YP_001587810.1 KEGG: shn:Shewana3_2650 2.9e-21 acetate kinase K00925; COG: COG4166 ABC-type oligopeptide transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001587811.1 KEGG: ath:At4g39230 3.0e-07 T22F8.130; isoflavone reductase, putative K00224; COG: NOG39315 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001587812.1 KEGG: shn:Shewana3_3435 1.7e-08 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001587813.1 Psort location: cytoplasmic, score: 23 YP_001587814.1 Psort location: cytoplasmic, score: 23 YP_001587815.1 KEGG: eci:UTI89_C0323 3.2e-135 2,5-diketo-D-gluconic acid reductase A K00100; COG: COG0656 Aldo/keto reductases, related to diketogulonate reductase; Psort location: cytoplasmic, score: 23 YP_001587816.1 KEGG: eco:b4249 1.0e-99 yjgI; predicted oxidoreductase with NAD(P)-binding Rossmann-fold domain; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: extracellular, including cell wall, score: 9 YP_001587817.1 COG: COG1309 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001587818.1 COG: NOG31342 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587819.1 COG: NOG26007 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587820.1 KEGG: bcz:BCZK3497 1.4e-07 adaA; transcriptional regulator, AraC family K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: vesicles of secretory system, score: 9 YP_001587821.1 COG: NOG24375 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001587822.1 COG: NOG08628 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587823.1 COG: NOG25390 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001587824.1 KEGG: rba:RB4586 1.4e-15 tpx; probable THIol peroxidase K00435; COG: COG2077 Peroxiredoxin; Psort location: cytoplasmic, score: 23 YP_001587825.1 COG: NOG18520 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587826.1 COG: COG3382 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001587827.1 Psort location: cytoplasmic, score: 23 YP_001587828.1 COG: COG1396 Predicted transcriptional regulators; Psort location: endoplasmic reticulum, score: 9 YP_001587829.1 COG: COG0668 Small-conductance mechanosensitive channel; Psort location: plasma membrane, score: 23 YP_001587830.1 COG: NOG14120 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001587831.1 with UspC and UspD is involved in resistance to UV irradiation YP_001587832.1 Global transcription factor that controls the expression of over 100 target genes in response to anoxia YP_001587833.1 KEGG: stt:t1563 3.9e-91 ogt; O6-methylguanine-DNA-alkyltransferase K00567; COG: COG0350 Methylated DNA-protein cysteine methyltransferase; Psort location: cytoplasmic, score: 23 YP_001587834.1 COG: COG2840 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001587835.1 Psort location: mitochondrial, score: 23 YP_001587836.1 Psort location: cytoplasmic, score: 23 YP_001587837.1 COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: extracellular, including cell wall, score: 23 YP_001587838.1 COG: COG0598 Mg2+ and Co2+ transporters; Psort location: cytoplasmic, score: 23 YP_001587839.1 exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA YP_001587840.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs YP_001587841.1 COG: COG0582 Integrase; Psort location: cytoplasmic, score: 23 YP_001587842.1 Psort location: cytoplasmic, score: 23 YP_001587843.1 KEGG: cbu:CBU_0996 0.0046 ctaB; protoheme IX farnesyltransferase K02301; COG: COG2076 Membrane transporters of cations and cationic drugs; Psort location: endoplasmic reticulum, score: 9 YP_001587844.1 COG: COG0589 Universal stress protein UspA and related nucleotide-binding proteins; Psort location: cytoplasmic, score: 23 YP_001587845.1 COG: NOG18465 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587846.1 Psort location: cytoplasmic, score: 23 YP_001587847.1 KEGG: nwi:Nwi_0782 3.1e-07 integrase, catalytic region K00986; COG: COG2801 Transposase and inactivated derivatives; Psort location: nuclear, score: 23 YP_001587848.1 KEGG: sty:STY1419 0. probable pyruvate-flavodoxin oxidoreductase K03737; COG: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit; Psort location: cytoplasmic, score: 23 YP_001587849.1 Psort location: nuclear, score: 23 YP_001587850.1 COG: COG3042 Putative hemolysin; Psort location: extracellular, including cell wall, score: 9 YP_001587851.1 COG: COG3187 Heat shock protein; Psort location: cytoplasmic, score: 23 YP_001587852.1 Psort location: endoplasmic reticulum, score: 9 YP_001587853.1 KEGG: spt:SPA1239 1.4e-173 ldhA; D-lactate dehydrogenase K03778; COG: COG1052 Lactate dehydrogenase and related dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001587854.1 COG: NOG06225 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001587855.1 COG: NOG17319 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001587856.1 COG: COG3784 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001587857.1 COG: COG3791 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001587858.1 FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds YP_001587859.1 involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain YP_001587860.1 COG: COG1434 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001587861.1 Psort location: nuclear, score: 23 YP_001587862.1 B-type di-heme cytochrome with a major alpha-absorption peak at 561 nm and a minor peak at 555 nm YP_001587863.1 KEGG: nmu:Nmul_A0349 0.00024 UbiE/COQ5 methyltransferase K00551; COG: COG0500 SAM-dependent methyltransferases; Psort location: cytoplasmic, score: 23 YP_001587864.1 Psort location: cytoplasmic, score: 23 YP_001587865.1 KEGG: azo:azo2381 7.0e-18 dolichyl-phosphate-mannose-protein mannosyltransferase K00728; COG: COG5305 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001587866.1 KEGG: hpa:HPAG1_0922 2.7e-19 amino acid ABC transporter, permease protein; COG: COG0765 ABC-type amino acid transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001587867.1 KEGG: stm:STM1635 6.5e-128 putative ABC-type polar amino acid transport system, ATPase component K02028; COG: COG1126 ABC-type polar amino acid transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001587868.1 KEGG: hpa:HPAG1_0922 1.2e-16 amino acid ABC transporter, permease protein; COG: COG0765 ABC-type amino acid transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001587869.1 KEGG: bur:Bcep18194_B0836 2.1e-21 ABC amino acid transporter, periplasmic ligand binding protein K01713; COG: COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; Psort location: extracellular, including cell wall, score: 9 YP_001587870.1 Psort location: cytoplasmic, score: 23 YP_001587871.1 KEGG: ctc:CTC01157 1.2e-08 phosphoesterase; COG: COG3326 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001587872.1 KEGG: aha:AHA_3791 5.5e-23 phosphatidylcholine-sterol acyltransferase K00650; COG: COG3240 Phospholipase/leciTHInase/hemolysin; Psort location: cytoplasmic, score: 23 YP_001587873.1 Psort location: cytoplasmic, score: 23 YP_001587874.1 Psort location: cytoplasmic, score: 23 YP_001587875.1 COG: NOG06184 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001587876.1 Psort location: cytoplasmic, score: 23 YP_001587877.1 Psort location: cytoplasmic, score: 23 YP_001587878.1 COG: COG1937 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001587879.1 KEGG: stm:STM1627 2.3e-203 alcohol dehydrogenase class III K00001:K00121; COG: COG1062 Zn-dependent alcohol dehydrogenases, class III; Psort location: mitochondrial, score: 23 YP_001587880.1 KEGG: vch:VCA0709 9.9e-05 torS; sensor protein TorS K07647; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001587881.1 KEGG: shn:Shewana3_3435 0.0036 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001587882.1 COG: COG5383 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001587883.1 KEGG: stm:STM1623 5.1e-279 putative carboxylesterase K03927; COG: COG2272 Carboxylesterase type B; Psort location: cytoplasmic, score: 23 YP_001587884.1 involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans YP_001587885.1 Psort location: mitochondrial, score: 23 YP_001587886.1 COG: COG2353 Uncharacterized conserved protein; Psort location: extracellular, including cell wall, score: 9 YP_001587887.1 KEGG: lpl:lp_3586 9.8e-102 lox; lactate oxidase K00119; COG: COG1304 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases; Psort location: extracellular, including cell wall, score: 9 YP_001587888.1 KEGG: cvi:CV0230 3.3e-30 probable aminoglycoside N6'-acetyltransferase K00663; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001587889.1 COG: COG1349 Transcriptional regulators of sugar metabolism; Psort location: cytoplasmic, score: 23 YP_001587890.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate YP_001587891.1 KEGG: sec:SC1612 4.3e-76 sgcA; putative sugar specific PTS enzyme II K02773; COG: COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type); Psort location: cytoplasmic, score: 23 YP_001587892.1 COG: COG0434 Predicted TIM-barrel enzyme; Psort location: cytoplasmic, score: 23 YP_001587893.1 KEGG: stt:t1523 6.2e-226 putative phosphotransferase enzyme K02775; COG: COG3775 Phosphotransferase system, galactitol-specific IIC component; Psort location: plasma membrane, score: 23 YP_001587894.1 KEGG: sty:STY1451 6.1e-45 putative phosphotransferase enzyme K02774; COG: COG3414 Phosphotransferase system, galactitol-specific IIB component; Psort location: nuclear, score: 23 YP_001587895.1 KEGG: mja:MJ0555 2.0e-53 endoglucanase K01179; COG: COG1363 Cellulase M and related proteins; Psort location: cytoplasmic, score: 23 YP_001587896.1 Psort location: cytoplasmic, score: 23 YP_001587897.1 KEGG: spt:SPA1258 6.1e-93 rimL; ribosomal-protein-serine acetyltransferase K03817; COG: COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins; Psort location: cytoplasmic, score: 23 YP_001587898.1 KEGG: mba:Mbar_A1937 1.4e-05 mannose-1-phosphate guanylyltransferase (GDP) K00966; COG: NOG06285 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587899.1 COG: COG1275 Tellurite resistance protein and related permeases; Psort location: endoplasmic reticulum, score: 9 YP_001587900.1 with TehA confers resistance to tellurite YP_001587901.1 COG: NOG06284 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001587902.1 KEGG: msm:MSMEG_1710 0.0019 ribose transport system permease protein RbsC; COG: COG3135 Uncharacterized protein involved in benzoate metabolism; Psort location: plasma membrane, score: 23 YP_001587903.1 KEGG: bxe:Bxe_C0924 0.00093 transcriptional regulator, XRE family with shikimate kinase activity K00891; COG: COG1396 Predicted transcriptional regulators; Psort location: mitochondrial, score: 23 YP_001587904.1 KEGG: stm:STM1604 0. ydcP; putative collagenase K08303; COG: COG0826 Collagenase and related proteases; Psort location: cytoplasmic, score: 23 YP_001587905.1 COG: NOG18519 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001587906.1 Psort location: nuclear, score: 23 YP_001587907.1 translocated by the type III secretion system SPI-2; localizes to Sifs in infected cells and specifically to Salmonella-containing vacuoles YP_001587908.1 Psort location: cytoplasmic, score: 23 YP_001587909.1 Psort location: nuclear, score: 23 YP_001587910.1 COG: NOG27850 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001587911.1 COG: NOG31445 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587912.1 KEGG: stm:STM1599 1.1e-139 pdgL; periplasmic dipeptidase precursor K08641; COG: COG2173 D-alanyl-D-alanine dipeptidase; Psort location: extracellular, including cell wall, score: 9 YP_001587913.1 KEGG: eci:UTI89_C1658 1.3e-216 ydcR; hypothetical protein YdcR K00811; COG: COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs; Psort location: cytoplasmic, score: 23 YP_001587914.1 Psort location: nuclear, score: 23 YP_001587915.1 catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation YP_001587916.1 Psort location: mitochondrial, score: 23 YP_001587917.1 Psort location: endoplasmic reticulum, score: 9 YP_001587918.1 COG: NOG12162 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587919.1 COG: COG4458 Uncharacterized protein conserved in bacteria, putative virulence factor; Psort location: cytoplasmic, score: 23 YP_001587920.1 COG: COG4457 Uncharacterized protein conserved in bacteria, putative virulence factor; Psort location: cytoplasmic, score: 23 YP_001587921.1 KEGG: mag:amb3277 3.2e-06 RTX toxins and related Ca2+-binding protein K00754; COG: NOG35976 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001587922.1 COG: NOG13890 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001587923.1 COG: COG3238 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001587924.1 KEGG: stm:STM1590 4.9e-91 yncA; putative acyltransferase K03823; COG: COG1247 Sortase and related acyltransferases; Psort location: cytoplasmic, score: 23 YP_001587925.1 KEGG: stm:STM1589 1.2e-190 yncB; putative NADP-dependent oxidoreductase; COG: COG2130 Putative NADP-dependent oxidoreductases; Psort location: mitochondrial, score: 23 YP_001587926.1 Psort location: mitochondrial, score: 23 YP_001587927.1 Psort location: extracellular, including cell wall, score: 9 YP_001587928.1 KEGG: msm:MSMEG_3400 4.1e-11 glutamyl-tRNA(Gln) amidotransferase subunit A K01957; COG: COG1802 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001587929.1 COG: COG1629 Outer membrane receptor proteins, mostly Fe transport; Psort location: extracellular, including cell wall, score: 9 YP_001587930.1 Psort location: nuclear, score: 23 YP_001587931.1 COG: COG3391 Uncharacterized conserved protein; Psort location: mitochondrial, score: 23 YP_001587932.1 COG: NOG30650 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001587933.1 KEGG: eci:UTI89_C0120 6.0e-86 aroP; aromatic amino acid transport protein AroP K03293; COG: COG1113 Gamma-aminobutyrate permease and related permeases; Psort location: plasma membrane, score: 23 YP_001587934.1 Psort location: nuclear, score: 23 YP_001587935.1 COG: NOG25496 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587936.1 Psort location: nuclear, score: 23 YP_001587937.1 KEGG: stm:STM1582 5.4e-156 nhoA; putative arylamine N-acetyltransferase K00675; COG: COG2162 Arylamine N-acetyltransferase; Psort location: cytoplasmic, score: 23 YP_001587938.1 KEGG: hma:rrnAC1794 1.2e-23 dapF; diaminopimelate epimerase K01778; COG: COG0384 Predicted epimerase, PhzC/PhzF homolog; Psort location: cytoplasmic, score: 23 YP_001587939.1 KEGG: stm:STM1580 3.4e-122 narV; nitrate reductase gamma chain K08347; COG: COG2181 Nitrate reductase gamma subunit; Psort location: plasma membrane, score: 23 YP_001587940.1 KEGG: stm:STM1579 1.1e-120 narW; nitrate reductase delta chain K08361; COG: COG2180 Nitrate reductase delta subunit; Psort location: cytoplasmic, score: 23 YP_001587941.1 KEGG: stm:STM1578 4.1e-293 narY; nitrate reductase beta chain K08346; COG: COG1140 Nitrate reductase beta subunit; Psort location: cytoplasmic, score: 23 YP_001587942.1 KEGG: stm:STM1577 0. narZ; nitrate reductase alpha chain K08345; COG: COG5013 Nitrate reductase alpha subunit; Psort location: cytoplasmic, score: 23 YP_001587943.1 Psort location: cytoplasmic, score: 23 YP_001587944.1 COG: COG2223 Nitrate/nitrite transporter; Psort location: plasma membrane, score: 23 YP_001587945.1 Psort location: mitochondrial, score: 23 YP_001587946.1 COG: COG1309 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001587947.1 KEGG: shn:Shewana3_1692 0.0014 Xaa-His dipeptidase K01270; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001587948.1 COG: COG3791 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001587949.1 Psort location: nuclear, score: 23 YP_001587950.1 COG: COG3203 Outer membrane protein (porin); Psort location: extracellular, including cell wall, score: 9 YP_001587951.1 Psort location: cytoplasmic, score: 23 YP_001587952.1 COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: plasma membrane, score: 23 YP_001587953.1 Psort location: mitochondrial, score: 23 YP_001587954.1 Psort location: mitochondrial, score: 23 YP_001587955.1 KEGG: stm:STM1569 5.9e-166 fdnH; formate dehydrogenase, iron-sulfur subunit (formate dehydrogenase beta subunit) K08349; COG: COG0437 Fe-S-cluster-containing hydrogenase components 1; Psort location: cytoplasmic, score: 23 YP_001587956.1 nitrate-inducible, cytochrome b556(fdn) component of formate dehydrogenase YP_001587957.1 similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs YP_001587958.1 Psort location: cytoplasmic, score: 23 YP_001587959.1 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate YP_001587960.1 protein D; stationary-phase-induced ribosome-associated; in Escherichia coli this protein becomes associated with the ribosome; expression increases during stationary phase YP_001587961.1 COG: NOG14119 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587962.1 KEGG: pfl:PFL_0043 2.1e-42 osmC; hydroperoxide resistance protein OsmC K04063; COG: COG1764 Predicted redox protein, regulator of disulfide bond formation; Psort location: cytoplasmic, score: 23 YP_001587963.1 COG: NOG11340 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001587964.1 COG: NOG09007 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001587965.1 KEGG: sme:SMb21447 9.0e-147 glgB2; putative 1,4-alpha-glucan branching enzyme protein K00700; COG: COG0296 1,4-alpha-glucan branching enzyme; Psort location: endoplasmic reticulum, score: 9 YP_001587966.1 KEGG: ret:RHE_PE00008 6.5e-208 putative maltooligosyl trehalose synthase protein; COG: COG3280 Maltooligosyl trehalose synthase; Psort location: cytoplasmic, score: 23 YP_001587967.1 KEGG: stm:STM1558 0. putative glycosyl hydrolase K02438; COG: COG1523 Type II secretory pathway, pullulanase PulA and related glycosidases; Psort location: cytoplasmic, score: 23 YP_001587968.1 KEGG: spt:SPA1313 4.7e-221 putative aminotransferase K00842; COG: COG1168 Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities; Psort location: cytoplasmic, score: 23 YP_001587969.1 COG: COG1757 Na+/H+ antiporter; Psort location: plasma membrane, score: 23 YP_001587970.1 KEGG: efa:EF1922 8.0e-06 transcriptional regulator, LacI family/carbohydrate kinase, PfkB family protein K00852; COG: COG1609 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001587971.1 COG: NOG25553 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001587972.1 Psort location: cytoplasmic, score: 23 YP_001587973.1 Psort location: cytoplasmic, score: 23 YP_001587974.1 Psort location: mitochondrial, score: 23 YP_001587975.1 COG: NOG06535 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001587976.1 Psort location: mitochondrial, score: 23 YP_001587977.1 KEGG: ape:APE_1501.1 5.0e-11 ribonuclease UK114; COG: COG0251 Putative translation initiation inhibitor, yjgF family; Psort location: cytoplasmic, score: 23 YP_001587978.1 KEGG: ser:SERP1204 2.2e-40 queA; S-adenosylmeTHIonine:tRNA ribosyltransferase-isomerase; COG: COG0809 S-adenosylmeTHIonine:tRNA-ribosyltransferase-isomerase (queuine synthetase); Psort location: cytoplasmic, score: 23 YP_001587979.1 Psort location: mitochondrial, score: 23 YP_001587980.1 COG: COG1846 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001587981.1 KEGG: pst:PSPTO_2645 3.0e-84 FAD-binding monooxygenase, PheA/TfdB family K05712; COG: COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases; Psort location: cytoplasmic, score: 23 YP_001587982.1 KEGG: shn:Shewana3_1692 0.0011 Xaa-His dipeptidase K01270; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001587983.1 Psort location: cytoplasmic, score: 23 YP_001587984.1 COG: COG4287 PhoPQ-activated pathogenicity-related protein; Psort location: endoplasmic reticulum, score: 9 YP_001587985.1 Psort location: mitochondrial, score: 23 YP_001587986.1 KEGG: ani:AN1180.2 0.00066 hypothetical protein K04428; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001587987.1 KEGG: stm:STM1542 1.7e-182 putative zinc-binding dehydrogenase K00100; COG: COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases; Psort location: endoplasmic reticulum, score: 9 YP_001587988.1 KEGG: reh:H16_B1289 4.0e-05 phnF; regulator of phosphonate operon, GntR-family; COG: COG2186 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001587989.1 KEGG: bur:Bcep18194_B0916 1.4e-40 penicillin amidase K01434; COG: COG3049 Penicillin V acylase and related amidases; Psort location: extracellular, including cell wall, score: 9 YP_001587990.1 Psort location: nuclear, score: 23 YP_001587991.1 KEGG: stm:STM1539 3.2e-183 hydrogenase small chain K06282; COG: COG1740 Ni,Fe-hydrogenase I small subunit; Psort location: cytoplasmic, score: 23 YP_001587992.1 KEGG: stm:STM1538 0. hydrogenase large chain K06281; COG: COG0374 Ni,Fe-hydrogenase I large subunit; Psort location: cytoplasmic, score: 23 YP_001587993.1 KEGG: eci:UTI89_C1042 7.6e-47 hyaC; probable Ni/Fe-hydrogenase 1 B-type cytochrome subunit K03620; COG: COG1969 Ni,Fe-hydrogenase I cytochrome b subunit; Psort location: endoplasmic reticulum, score: 9 YP_001587994.1 KEGG: sec:SC1553 9.5e-104 hupD; putative hydrogenase maturation protease K03605; COG: COG0680 Ni,Fe-hydrogenase maturation factor; Psort location: cytoplasmic, score: 23 YP_001587995.1 COG: NOG17080 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587996.1 COG: NOG22061 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001587997.1 KEGG: eci:UTI89_C1045 1.0e-35 hyaF; hydrogenase-1 operon protein HyaF K03618; COG: COG1773 Rubredoxin; Psort location: extracellular, including cell wall, score: 9 YP_001587998.1 COG: NOG36839 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001587999.1 COG: COG0375 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression); Psort location: cytoplasmic, score: 23 YP_001588000.1 COG: COG3203 Outer membrane protein (porin); Psort location: extracellular, including cell wall, score: 9 YP_001588001.1 COG: NOG24917 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001588002.1 COG: COG3781 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 23 YP_001588003.1 Psort location: nuclear, score: 23 YP_001588004.1 COG: NOG13916 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001588005.1 catalyzes the formation of glutamate from glutamine YP_001588006.1 in Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase YP_001588007.1 COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001588008.1 KEGG: dre:30298 3.2e-06 jak2b; Janus kinase 2b K04447; COG: COG2814 Arabinose efflux permease; Psort location: plasma membrane, score: 23 YP_001588009.1 protein involved in resistance to different drugs (tetracycline, chloramphenicol, beta-lactams, and quinolones); part of the multiple antibiotic resistance (mar) locus, which is composed by the genes marC and marRAB; unknown function YP_001588010.1 Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes YP_001588011.1 transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype; also activates sodA, zwf and micF YP_001588012.1 COG: NOG15370 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001588013.1 KEGG: pae:PA1977 4.8e-05 sensor protein GLPS; COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: plasma membrane, score: 23 YP_001588014.1 YdeF; uncharacterized member of the major facilitator superfamily (MFS) of transporters YP_001588015.1 Psort location: endoplasmic reticulum, score: 9 YP_001588016.1 Psort location: cytoplasmic, score: 23 YP_001588017.1 COG: COG3111 Uncharacterized conserved protein; Psort location: extracellular, including cell wall, score: 9 YP_001588018.1 Psort location: cytoskeletal, score: 9 YP_001588019.1 Psort location: cytoplasmic, score: 23 YP_001588020.1 COG: COG1546 Uncharacterized protein (competence- and mitomycin-induced); Psort location: cytoplasmic, score: 23 YP_001588021.1 Psort location: mitochondrial, score: 23 YP_001588022.1 Psort location: cytoplasmic, score: 23 YP_001588023.1 KEGG: stm:STM1512 0. dcp; dipeptidyl carboxypeptidase II K01284; COG: COG0339 Zn-dependent oligopeptidases; Psort location: cytoplasmic, score: 23 YP_001588024.1 NADP(+)-dependent; catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine YP_001588025.1 KEGG: msm:MSMEG_3400 1.1e-07 glutamyl-tRNA(Gln) amidotransferase subunit A K01957; COG: COG1802 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001588026.1 COG: NOG13886 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588027.1 KEGG: stm:STM1508 8.5e-261 ydfI; putative mannitol dehydrogenase K00040; COG: COG0246 Mannitol-1-phosphate/altronate dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001588028.1 Psort location: cytoplasmic, score: 23 YP_001588029.1 KEGG: cal:orf19.2425 2.8e-05 highly conserved hypothetical protein K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001588030.1 KEGG: stm:STM1506 1.4e-180 rspB; putative dehydrogenase K08322; COG: COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001588031.1 KEGG: eci:UTI89_C1768 1.5e-217 rspA; starvation sensing protein RspA K08323; COG: COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily; Psort location: cytoplasmic, score: 23 YP_001588032.1 KEGG: mta:Moth_2191 0.0082 NADH dehydrogenase (quinone) K05903; COG: COG1742 Uncharacterized conserved protein; Psort location: extracellular, including cell wall, score: 23 YP_001588033.1 Psort location: cytoplasmic, score: 23 YP_001588034.1 COG: NOG11441 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001588035.1 KEGG: sec:SC1519 3.9e-98 speG; spermidine N1-acetyltransferase K00657; COG: COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins; Psort location: cytoplasmic, score: 23 YP_001588036.1 COG: NOG06202 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001588037.1 COG: NOG12175 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001588038.1 KEGG: stm:STM1499 0. putative dimethyl sulphoxide reductase, chain A1 K07309; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: cytoplasmic, score: 23 YP_001588039.1 KEGG: stm:STM1498 0. putative dimethyl sulphoxide reductase K07310; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: mitochondrial, score: 23 YP_001588040.1 KEGG: ecp:ECP_0909 1.0e-115 anaerobic dimethyl sulfoxide reductase, subunit B K07307; COG: COG0437 Fe-S-cluster-containing hydrogenase components 1; Psort location: nuclear, score: 23 YP_001588041.1 KEGG: eci:UTI89_C1777 2.0e-119 ynfH; anaerobic dimethyl sulfoxide reductase chain YnfH K07312; COG: COG3302 DMSO reductase anchor subunit; Psort location: plasma membrane, score: 23 YP_001588042.1 binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane YP_001588043.1 KEGG: lwe:lwe1439 8.6e-39 glycine betaine/L-proline ABC transporter, permease/glycine betaine/L-proline-binding protein; COG: COG1174 ABC-type proline/glycine betaine transport systems, permease component; Psort location: endoplasmic reticulum, score: 23 YP_001588044.1 KEGG: lwe:lwe1443 6.0e-31 opuCC; glycine betaine/L-proline ABC transporter, glycine betaine/L-proline-binding protein; COG: COG1732 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein); Psort location: extracellular, including cell wall, score: 9 YP_001588045.1 KEGG: lwe:lwe1439 3.5e-42 glycine betaine/L-proline ABC transporter, permease/glycine betaine/L-proline-binding protein; COG: COG1174 ABC-type proline/glycine betaine transport systems, permease component; Psort location: plasma membrane, score: 23 YP_001588046.1 KEGG: bur:Bcep18194_C7553 6.8e-133 ABC glycine betaine/L-proline transporter, ATPase subunit K05847; COG: COG1125 ABC-type proline/glycine betaine transport systems, ATPase components; Psort location: cytoplasmic, score: 23 YP_001588047.1 KEGG: cpr:CPR_1400 1.2e-23 chloride channel protein K01529; COG: COG0038 Chloride channel protein EriC; Psort location: plasma membrane, score: 23 YP_001588048.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium YP_001588049.1 KEGG: eci:UTI89_C1781 7.8e-196 mlc; putative NAGC-like transcriptional regulator K00845; COG: COG1940 Transcriptional regulator/sugar kinase; Psort location: cytoplasmic, score: 23 YP_001588050.1 KEGG: shn:Shewana3_3435 7.0e-21 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001588051.1 KEGG: shn:Shewana3_1692 3.1e-50 Xaa-His dipeptidase K01270; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001588052.1 Psort location: mitochondrial, score: 23 YP_001588053.1 required for growth and survival under moderately acid conditions YP_001588054.1 Psort location: golgi, score: 9 YP_001588055.1 KEGG: spt:SPA1370 4.8e-148 putative secreted protein K04775; COG: COG3591 V8-like Glu-specific endopeptidase; Psort location: extracellular, including cell wall, score: 9 YP_001588056.1 with MdtJ is involved in resistance to deoxycholate, nalidixic acid, fosfomycin, and SDS YP_001588057.1 with MdtI is involved in resistance to deoxycholate , nalidixic acid, fosfomycin, and SDS YP_001588058.1 Psort location: nuclear, score: 23 YP_001588059.1 Psort location: cytoplasmic, score: 23 YP_001588060.1 transport of quorum-sensing signal; mutations in this gene alters the transport of the quorum-sensing signal autoinducer 2 (AI-2) which affects expression of a large number of genes YP_001588061.1 catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme YP_001588062.1 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm YP_001588063.1 Psort location: cytoplasmic, score: 23 YP_001588064.1 COG: NOG06063 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001588065.1 Psort location: nuclear, score: 23 YP_001588066.1 Psort location: endoplasmic reticulum, score: 9 YP_001588067.1 KEGG: eci:UTI89_C0120 1.6e-09 aroP; aromatic amino acid transport protein AroP K03293; COG: COG0531 Amino acid transporters; Psort location: plasma membrane, score: 23 YP_001588068.1 KEGG: dre:494109 0.0033 zgc:101688 K00516; COG: COG3136 Uncharacterized membrane protein required for alginate biosynthesis; Psort location: endoplasmic reticulum, score: 9 YP_001588069.1 response regulator in two-component regulatory system with RstB YP_001588070.1 Psort location: cytoplasmic, score: 23 YP_001588071.1 COG: NOG29757 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588072.1 COG: COG3203 Outer membrane protein (porin); Psort location: extracellular, including cell wall, score: 9 YP_001588073.1 KEGG: hma:rrnAC3411 6.3e-12 metal dependent amidohydrolase superfamily protein K01443:K01427:K01465:K01486; COG: COG1574 Predicted metal-dependent hydrolase with the TIM-barrel fold; Psort location: extracellular, including cell wall, score: 9 YP_001588074.1 KEGG: stm:STM1471 1.2e-229 rstB; sensory histidine kinase in two-component regulatory system with RstA K07639; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 9 YP_001588075.1 binds to DNA replication terminator sequences to prevent passage of replication forks YP_001588076.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_001588077.1 KEGG: spt:SPA1387 2.1e-296 fumA; Fumarate hydratase class I, aerobic K01676; COG: COG1951 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain; Psort location: cytoplasmic, score: 23 YP_001588078.1 KEGG: spt:SPA1388 7.6e-205 manA; mannose-6-phosphate isomerase K01809; COG: COG1482 Phosphomannose isomerase; Psort location: cytoplasmic, score: 23 YP_001588079.1 COG: COG5339 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001588080.1 COG: COG1609 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001588081.1 KEGG: sec:SC1481 7.1e-67 malY; MalY protein [includes: cystaTHIonine beta-lyase K01760; COG: COG1168 Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities; Psort location: cytoplasmic, score: 23 YP_001588082.1 Psort location: nuclear, score: 23 YP_001588083.1 KEGG: sec:SC1480 3.0e-132 add; adenosine deaminase K01488; COG: COG1816 Adenosine deaminase; Psort location: cytoplasmic, score: 23 YP_001588084.1 KEGG: eci:UTI89_C1812 1.6e-172 ydgJ; hypothetical oxidoreductase YdgJ; COG: COG0673 Predicted dehydrogenases and related proteins; Psort location: cytoplasmic, score: 23 YP_001588085.1 YdgT; in E. coli, when complexed with H-NS or StpA binds a 26 base-pair DNA sequence of oriC; seems to play a role in optimizing the activity of oriC; non-essential; Hha protein paralog; in an hha mutant background, cnu is overexpressed and can compensate hha-induced phenotypes YP_001588086.1 COG: NOG08686 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001588087.1 KEGG: vfi:VF0935 6.8e-78 Na(+)-translocating NADH-quinone reductase subunit E K03617; COG: COG4657 Predicted NADH:ubiquinone oxidoreductase, subunit RnfA; Psort location: plasma membrane, score: 23 YP_001588088.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen YP_001588089.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen YP_001588090.1 RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents YP_001588091.1 part of membrane-bound complex hought to be involved in electron transport to nitrogen YP_001588092.1 in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase YP_001588093.1 DNA-(apurinic or apyrimidinic site) lyase; has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity; removed damaged DNA at cytosines, thymines and guanines YP_001588094.1 Psort location: cytoplasmic, score: 23 YP_001588095.1 mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium; member of proton-dependent oligopeptide transport (POT) system family; in Escherichia coli this gene is regulated by OmpR although not via osmoregulation YP_001588096.1 KEGG: stm:STM1451 5.1e-105 gst; glutaTHIonine S-transferase K00799; COG: COG0625 GlutaTHIone S-transferase; Psort location: cytoplasmic, score: 23 YP_001588097.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal YP_001588098.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) YP_001588099.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate YP_001588100.1 MliC; membrane-bound lysozyme inhibitor of c-type lysozyme YP_001588101.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling YP_001588102.1 COG: COG3133 Outer membrane lipoprotein; Psort location: extracellular, including cell wall, score: 9 YP_001588103.1 Transcription regulator that can both activate or repress expression YP_001588104.1 COG: NOG13888 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588105.1 COG: COG1566 Multidrug resistance efflux pump; Psort location: endoplasmic reticulum, score: 9 YP_001588106.1 COG: COG1289 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001588107.1 SodC; copper and zinc binding; converts superoxide radicals to hydrogen peroxide and water YP_001588108.1 KEGG: ecc:c2039 7.3e-145 ydhF; hypothetical oxidoreductase YdhF; COG: COG4989 Predicted oxidoreductase; Psort location: cytoskeletal, score: 9 YP_001588109.1 COG: COG3313 Predicted Fe-S protein; Psort location: nuclear, score: 23 YP_001588110.1 KEGG: bpm:BURPS1710b_A2293 4.4e-35 TetR-family regulatory protein K00356; COG: COG1309 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001588111.1 Ni-dependent; catalyzes the formation of S-lactoylglutathione from methylglyoxal and glutathione YP_001588112.1 Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A) YP_001588113.1 KEGG: ama:AM1083 1.2e-07 grxC1; glutaredoxin 3 K03676; COG: COG0278 Glutaredoxin-related protein; Psort location: cytoplasmic, score: 23 YP_001588114.1 Psort location: nuclear, score: 23 YP_001588115.1 KEGG: ssn:SSO_1501 7.4e-104 ydhO; putative lipoprotein K01183; COG: COG0791 Cell wall-associated hydrolases (invasion-associated proteins); Psort location: mitochondrial, score: 23 YP_001588116.1 SodB; iron binding; present under aerobic and anaerobic conditions; destroys free radicals YP_001588117.1 Psort location: cytoplasmic, score: 23 YP_001588118.1 binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers YP_001588119.1 KEGG: shn:Shewana3_3435 0.00063 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001588120.1 Psort location: mitochondrial, score: 23 YP_001588121.1 uncharacterized member of the major facilitator superfamily (MFS) YP_001588122.1 catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge YP_001588123.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine YP_001588124.1 NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones YP_001588125.1 Psort location: cytoplasmic, score: 23 YP_001588126.1 member of a type III secretion system which is part of a pathogenicity island in Salmonella, Yersinia and pathogenic Escherichia coli YP_001588127.1 COG: COG4791 Type III secretory pathway, component EscT; Psort location: endoplasmic reticulum, score: 9 YP_001588128.1 COG: COG4794 Type III secretory pathway, component EscS; Psort location: endoplasmic reticulum, score: 9 YP_001588129.1 part of a set of proteins involved in the infection of eukaryotic cells; in plant pathogens involved in the hypersensitivity response YP_001588130.1 COG: COG1886 Flagellar motor switch/type III secretory pathway protein; Psort location: cytoplasmic, score: 23 YP_001588131.1 COG: NOG24542 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588132.1 COG: NOG23008 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001588133.1 KEGG: stm:STM1415 2.5e-231 ssaN; Secretion system apparatus: homology with the YscN family of proteins K03224; COG: COG1157 Flagellar biosynthesis/type III secretory pathway ATPase; Psort location: cytoplasmic, score: 23 YP_001588134.1 with SsaC forms part of a protein export system across the inner and outer cell membranes; part of the Salmonella pathogenicity island 2; part of the type III secretion system YP_001588135.1 COG: NOG15484 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588136.1 COG: NOG09839 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588137.1 COG: NOG14113 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588138.1 COG: NOG12246 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588139.1 COG: COG4669 Type III secretory pathway, lipoprotein EscJ; Psort location: cytoplasmic, score: 23 YP_001588140.1 COG: NOG23089 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001588141.1 COG: NOG22388 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588142.1 COG: NOG18517 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001588143.1 COG: NOG26042 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001588144.1 COG: NOG26742 non supervised orthologous group; Psort location: plasma membrane, score: 23 YP_001588145.1 KEGG: ter:Tery_0416 1.1e-05 1-deoxy-D-xylulose 5-phosphate reductoisomerase K00099; COG: COG0457 FOG: TPR repeat; Psort location: cytoplasmic, score: 23 YP_001588146.1 COG: NOG20797 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588147.1 COG: NOG18516 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001588148.1 KEGG: dre:317747 0.0064 rock2; rho-associated, coiled-coil containing protein kinase 2 K04514; COG: COG5613 Uncharacterized conserved protein; Psort location: mitochondrial, score: 23 YP_001588149.1 COG: COG0457 FOG: TPR repeat; Psort location: mitochondrial, score: 23 YP_001588150.1 COG: NOG20796 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001588151.1 COG: NOG23007 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001588152.1 Psort location: cytoplasmic, score: 23 YP_001588153.1 COG: NOG24541 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001588154.1 COG: NOG08735 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001588155.1 COG: COG1450 Type II secretory pathway, component PulD; Psort location: extracellular, including cell wall, score: 9 YP_001588156.1 COG: NOG20795 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588157.1 KEGG: sec:SC1413 0. ssrA; secretion system regulator:sensor component K00873; COG: COG0784 FOG: CheY-like receiver; Psort location: endoplasmic reticulum, score: 23 YP_001588158.1 KEGG: pha:PSHAa1916 6.3e-27 uvrY, sirA; response regulator K07689; COG: COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; Psort location: cytoplasmic, score: 23 YP_001588159.1 Psort location: mitochondrial, score: 23 YP_001588160.1 KEGG: eci:UTI89_C3737 8.5e-06 yhdM; Zn(II)-responsive regulator of ZntA; COG: COG0789 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001588161.1 Psort location: nuclear, score: 23 YP_001588162.1 COG: COG3272 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001588163.1 COG: NOG13889 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588164.1 KEGG: rru:Rru_A1500 2.0e-17 signal transduction histidine kinase (STHK) with CheB and CheR activity K03412:K00575; COG: COG4566 Response regulator; Psort location: cytoplasmic, score: 23 YP_001588165.1 KEGG: stm:STM1386 0. ttrS; sensory histidine kinase K00873; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 9 YP_001588166.1 KEGG: pai:PAE1263 5.4e-46 molybdopterin oxidoreductase, iron-sulfur binding subunit K00184; COG: COG0437 Fe-S-cluster-containing hydrogenase components 1; Psort location: extracellular, including cell wall, score: 9 YP_001588167.1 KEGG: afu:AF2386 8.2e-07 molybdopterin oxidoreductase, membrane subunit K00185; COG: NOG06755 non supervised orthologous group; Psort location: plasma membrane, score: 23 YP_001588168.1 KEGG: afu:AF0159 3.3e-94 molybdopterin oxidoreductase, molybdopterin binding subunit K00183; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: extracellular, including cell wall, score: 9 YP_001588169.1 KEGG: cpe:CPE1632 3.1e-50 rbsK; ribokinase K00852; COG: COG0524 Sugar kinases, ribokinase family; Psort location: cytoplasmic, score: 23 YP_001588170.1 COG: COG5426 Uncharacterized membrane protein; Psort location: cytoskeletal, score: 9 YP_001588171.1 KEGG: xcb:XC_1296 3.3e-53 proline imino-peptidase K01259; COG: COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily); Psort location: cytoplasmic, score: 23 YP_001588172.1 KEGG: eci:UTI89_C0120 1.2e-07 aroP; aromatic amino acid transport protein AroP K03293; COG: COG0531 Amino acid transporters; Psort location: plasma membrane, score: 23 YP_001588173.1 Psort location: cytoplasmic, score: 23 YP_001588174.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_001588175.1 COG: COG4238 Murein lipoprotein; Psort location: extracellular, including cell wall, score: 9 YP_001588176.1 KEGG: eci:UTI89_C2228 8.4e-64 erfK; hypothetical protein K00257; COG: COG1376 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001588177.1 Acts with SufS to catalyze the formation of L-alanine from L-cysteine YP_001588178.1 catalyzes the formation of L-alanine and selenide or sulfanylcysteine from selenocysteine or cysteine YP_001588179.1 with SufBC activates cysteine desulfurase SufS YP_001588180.1 part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE YP_001588181.1 with SufCD activates cysteine desulfurase SufS YP_001588182.1 functions as a scaffold on which iron-sulfur clusters ([2Fe-2S]; [4Fe-4S]) are assembled; forms a homodimer; similar to IscA protein YP_001588183.1 KEGG: eci:UTI89_C4668 1.2e-30 gltP; glutamate-aspartate symport protein K03309; COG: COG1823 Predicted Na+/dicarboxylate symporter; Psort location: plasma membrane, score: 23 YP_001588184.1 COG: NOG11331 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588185.1 KEGG: eco:b1686 1.4e-63 ydiI; hypothetical protein; COG: COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism; Psort location: cytoplasmic, score: 23 YP_001588186.1 KEGG: eci:UTI89_C1879 0. ydiJ; hypothetical protein YdiJ; COG: COG0247 Fe-S oxidoreductase; Psort location: cytoplasmic, score: 23 YP_001588187.1 Psort location: cytoplasmic, score: 23 YP_001588188.1 YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function YP_001588189.1 COG: NOG09765 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001588190.1 KEGG: cal:orf19.6005 0.0064 STL13; sugar transporter K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001588191.1 Psort location: cytoplasmic, score: 23 YP_001588192.1 Psort location: mitochondrial, score: 23 YP_001588193.1 KEGG: lin:lin0026 0.0032 similar to PTS system, beta-glucosides specific enzyme IIABC K02755:K02756:K02757; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001588194.1 YdiB; quinate/shikimate dehydrogenase from Escherichia coli uses both NAD and NAD(P) to convert quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate YP_001588195.1 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis YP_001588196.1 KEGG: eci:UTI89_C1886 1.3e-264 ydiF; hypothetical protein YdiF K01026; COG: COG4670 Acyl CoA:acetate/3-ketoacid CoA transferase; Psort location: cytoplasmic, score: 23 YP_001588197.1 may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain YP_001588198.1 KEGG: btl:BALH_3368 2.9e-14 adaA; transcriptional regulator, AraC family K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001588199.1 Psort location: cytoplasmic, score: 23 YP_001588200.1 YdiO, YdiQ, YdiR, YdiS, and YdiT may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain YP_001588201.1 May play a role in a redox process YP_001588202.1 KEGG: stm:STM1352 3.6e-223 ydiS; flavoprotein K00313; COG: COG0644 Dehydrogenases (flavoproteins); Psort location: cytoplasmic, score: 23 YP_001588203.1 KEGG: hma:rrnAC0094 0.00016 ydiS; flavoprotein probably electron transport K00313; COG: COG2440 Ferredoxin-like protein; Psort location: cytoplasmic, score: 23 YP_001588204.1 acts in anaerobic beta-oxidation of fatty acids; possible ligase/synthase involved in anaerobic growth on fatty acids YP_001588205.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_001588206.1 Psort location: cytoplasmic, score: 23 YP_001588207.1 COG: COG1806 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001588208.1 Psort location: mitochondrial, score: 23 YP_001588209.1 tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate YP_001588210.1 COG: COG4256 Hemin uptake protein; Psort location: nuclear, score: 23 YP_001588211.1 COG: COG0397 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001588212.1 COG: COG2200 FOG: EAL domain; Psort location: cytoplasmic, score: 23 YP_001588213.1 Psort location: cytoplasmic, score: 23 YP_001588214.1 KEGG: eci:UTI89_C1901 7.5e-72 nlpC; probable lipoprotein NlpC precursor; COG: COG0791 Cell wall-associated hydrolases (invasion-associated proteins); Psort location: extracellular, including cell wall, score: 9 YP_001588215.1 ATP-binding protein that acts with the transmembrane protein BtuC and the solute binding protein BtuF to transport vitamin B12 into the cell YP_001588216.1 similar to glutathione peroxidase; member of the btuCED operon which is required for vitamin B12 transport across the inner membrane YP_001588217.1 with BtuD and BtuF transports vitamin B12 into the cell YP_001588218.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_001588219.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_001588220.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_001588221.1 Psort location: mitochondrial, score: 23 YP_001588222.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_001588223.1 COG: COG0291 Ribosomal protein L35; Psort location: cytoplasmic, score: 23 YP_001588224.1 KEGG: fth:FTH_1368 3.4e-35 infC; protein-synthesizing GTPase; COG: COG0290 Translation initiation factor 3 (IF-3); Psort location: nuclear, score: 23 YP_001588225.1 catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001588226.1 Psort location: cytoplasmic, score: 23 YP_001588227.1 Psort location: cytoplasmic, score: 23 YP_001588228.1 Psort location: cytoplasmic, score: 23 YP_001588229.1 KEGG: sha:SH0994 0.00024 agrC; AgrC K07706; COG: NOG08734 non supervised orthologous group; Psort location: plasma membrane, score: 23 YP_001588230.1 KEGG: pat:Patl_0573 1.4e-47 endonuclease; COG: COG1864 DNA/RNA endonuclease G, NUC1; Psort location: extracellular, including cell wall, score: 9 YP_001588231.1 COG: NOG30047 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588232.1 COG: COG3528 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001588233.1 COG: COG3137 Putative salt-induced outer membrane protein; Psort location: extracellular, including cell wall, score: 9 YP_001588234.1 KEGG: stm:STM1326 7.5e-159 pfkB; 6-phosphofructokinase II K00850; COG: COG1105 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB); Psort location: extracellular, including cell wall, score: 9 YP_001588235.1 COG: NOG12163 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588236.1 KEGG: eci:UTI89_C1919 3.3e-149 yniA; hypothetical protein YniA K00924; COG: COG3001 Fructosamine-3-kinase; Psort location: cytoplasmic, score: 23 YP_001588237.1 COG: NOG07880 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 23 YP_001588238.1 YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate YP_001588239.1 COG: COG1988 Predicted membrane-bound metal-dependent hydrolases; Psort location: cytoplasmic, score: 23 YP_001588240.1 KEGG: eci:UTI89_C4668 4.9e-36 gltP; glutamate-aspartate symport protein K03309; COG: COG1823 Predicted Na+/dicarboxylate symporter; Psort location: plasma membrane, score: 23 YP_001588241.1 COG: NOG11329 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001588242.1 Catalase HPII; monofunctional catalase that decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide YP_001588243.1 KEGG: eci:UTI89_C1926 1.2e-105 ydjC; hypothetical protein YdjC K03478; COG: COG3394 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001588244.1 KEGG: sec:SC1337 7.7e-244 celF; phospho-beta-glucosidase (cellobiose-6-phosphate hydrolase) K01222; COG: COG1486 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases; Psort location: cytoplasmic, score: 23 YP_001588245.1 represses the celABCDF-ydjC operon involved in carbon uptake YP_001588246.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake YP_001588247.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake YP_001588248.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake YP_001588249.1 osmotically-inducible lipoprotein E; activator of ntr-like gene protein YP_001588250.1 Psort location: mitochondrial, score: 23 YP_001588251.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers YP_001588252.1 Psort location: cytoplasmic, score: 23 YP_001588253.1 3' incision activity; acts with UvrC YP_001588254.1 periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP YP_001588255.1 Psort location: cytoplasmic, score: 23 YP_001588256.1 catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism YP_001588257.1 catalyzes the hydrolysis of 2-N-succinylarginine into 2-N-succinylornithine, ammonia and carbon dioxide in arginine degradation YP_001588258.1 a high throughput screen identified this enzyme as an aldehyde dehydrogenase with broad substrate specificity; converts succinylglutamate semialdehyde and NAD to succinylglutamate and NADH YP_001588259.1 KEGG: spt:SPA1540 3.4e-186 astA; arginine succinyltransferase K00673; COG: COG3138 Arginine/orniTHIne N-succinyltransferase beta subunit; Psort location: cytoplasmic, score: 23 YP_001588260.1 catalyzes the transamination of 2-N-succinylornithine and alpha-ketoglutarate into 2-N-succinylglutamate semialdehyde and glutamate; also functions as the catabolic acetylornithine aminotransferase catalyzing the formation of 2-N-acetylglutamate semialdehyde and glutamate from 2-N-acetylornithine and alpha-ketoglutarate YP_001588261.1 Psort location: mitochondrial, score: 23 YP_001588262.1 removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction YP_001588263.1 KEGG: sec:SC1323 3.2e-71 nudG; putative mutator MutT protein K08320; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: cytoplasmic, score: 23 YP_001588264.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer YP_001588265.1 decatenates replicating daughter chromosomes YP_001588266.1 catalyzes the formation of selenophosphate from selenide and ATP YP_001588267.1 KEGG: sbo:SBO_1322 1.2e-85 ydjA; hypothetical protein; COG: COG0778 Nitroreductase; Psort location: cytoplasmic, score: 23 YP_001588268.1 SppA; catalyzes the degradation of cleaved signal peptides; essential to maintain secretion of mature proteins across the membrane YP_001588269.1 Psort location: nuclear, score: 23 YP_001588270.1 converts asparagine to aspartate and ammonia YP_001588271.1 catalyzes the formation of nicotinate from nicotinamide in NAD biosynthesis and the formation of pyrazinoate from pyrazinamide YP_001588272.1 Psort location: mitochondrial, score: 23 YP_001588273.1 COG: COG3139 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001588274.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress YP_001588275.1 Psort location: mitochondrial, score: 23 YP_001588276.1 KEGG: stt:t1169 3.5e-152 gapA; glyceraldehyde 3-phosphate dehydrogenase A K00134; COG: COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Psort location: cytoplasmic, score: 23 YP_001588277.1 KEGG: tbd:Tbd_2730 2.4e-33 dihydroxy-acid dehydratase K01687; COG: COG0676 Uncharacterized enzymes related to aldose 1-epimerase; Psort location: cytoplasmic, score: 23 YP_001588278.1 KEGG: syg:sync_2368 3.3e-14 arylsulfatase regulator; COG: COG0641 Arylsulfatase regulator (Fe-S oxidoreductase); Psort location: cytoplasmic, score: 23 YP_001588279.1 COG: COG3713 Outer membrane protein V; Psort location: extracellular, including cell wall, score: 9 YP_001588280.1 Psort location: nuclear, score: 23 YP_001588281.1 KEGG: eci:UTI89_C1979 0. yeaG; hypothetical protein K07180; COG: COG2766 Putative Ser protein kinase; Psort location: cytoplasmic, score: 23 YP_001588282.1 Psort location: mitochondrial, score: 23 YP_001588283.1 KEGG: eci:UTI89_C1980 7.1e-218 yeaH; hypothetical protein YeaH K00754; COG: COG2718 Uncharacterized conserved protein; Psort location: mitochondrial, score: 23 YP_001588284.1 Psort location: extracellular, including cell wall, score: 9 YP_001588285.1 KEGG: eci:UTI89_C1612 2.0e-13 ydaM; hypothetical protein YdaM; COG: COG2199 FOG: GGDEF domain; Psort location: endoplasmic reticulum, score: 9 YP_001588286.1 KEGG: lpl:lp_2048 0.0084 proS, pro; prolyl-tRNA synthetase K01881; COG: COG2606 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001588287.1 Psort location: endoplasmic reticulum, score: 9 YP_001588288.1 Psort location: nuclear, score: 23 YP_001588289.1 COG: COG2707 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001588290.1 COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001588291.1 KEGG: pca:Pcar_2776 0.00082 2-acyl-glycerophospho-ethanolamine acyltransferase K05939:K01909; COG: COG2807 Cyanate permease; Psort location: plasma membrane, score: 23 YP_001588292.1 Psort location: nuclear, score: 23 YP_001588293.1 KEGG: eci:UTI89_C1988 2.7e-44 yeaO; hypothetical protein K00589; COG: COG3189 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001588294.1 COG: NOG29442 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588295.1 COG: COG3042 Putative hemolysin; Psort location: nuclear, score: 23 YP_001588296.1 Psort location: cytoplasmic, score: 23 YP_001588297.1 Psort location: golgi, score: 9 YP_001588298.1 KEGG: cya:CYA_1318 0.0051 gspO; prepilin peptidase K02464; COG: COG2261 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001588299.1 COG: NOG24806 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001588300.1 Psort location: cytoplasmic, score: 23 YP_001588301.1 Psort location: nuclear, score: 23 YP_001588302.1 COG: NOG15334 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 23 YP_001588303.1 COG: COG3615 Uncharacterized protein/domain, possibly involved in tellurite resistance; Psort location: mitochondrial, score: 23 YP_001588304.1 Psort location: mitochondrial, score: 23 YP_001588305.1 Psort location: nuclear, score: 23 YP_001588306.1 COG: COG1280 Putative threonine efflux protein; Psort location: plasma membrane, score: 23 YP_001588307.1 catalyzes the interconversion of chorismate to prephenate YP_001588308.1 COG: NOG34337 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001588309.1 COG: NOG23111 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588310.1 COG: COG0789 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001588311.1 COG: COG2771 DNA-binding HTH domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001588312.1 streptomycin 3'-adenyltransferase YP_001588313.1 Psort location: nuclear, score: 23 YP_001588314.1 COG: COG3443 Predicted periplasmic or secreted protein; Psort location: extracellular, including cell wall, score: 9 YP_001588315.1 Psort location: mitochondrial, score: 23 YP_001588316.1 KEGG: mja:MJ0155 0.0035 formate dehydrogenase, iron-sulfur subunit K00124; COG: COG1145 Ferredoxin; Psort location: nuclear, score: 23 YP_001588317.1 COG: COG0668 Small-conductance mechanosensitive channel; Psort location: endoplasmic reticulum, score: 9 YP_001588318.1 KEGG: ava:Ava_B0212 5.9e-40 ABC transporter-like K02032; COG: COG1124 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001588319.1 KEGG: ava:Ava_B0213 2.2e-31 oligopeptide/dipeptide ABC transporter, ATP-binding protein-like K02031; COG: COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase; Psort location: mitochondrial, score: 23 YP_001588320.1 COG: COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; Psort location: endoplasmic reticulum, score: 23 YP_001588321.1 KEGG: rha:RHA1_ro09047 1.2e-32 ABC peptide transporter, permease component K02033; COG: COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001588322.1 KEGG: shn:Shewana3_2650 1.8e-06 acetate kinase K00925; COG: COG0747 ABC-type dipeptide transport system, periplasmic component; Psort location: endoplasmic reticulum, score: 9 YP_001588323.1 Psort location: endoplasmic reticulum, score: 9 YP_001588324.1 Psort location: extracellular, including cell wall, score: 9 YP_001588325.1 COG: NOG18515 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001588326.1 KEGG: eca:ECA0823 1.4e-38 cybB; cytochrome B561; COG: COG3038 Cytochrome B561; Psort location: endoplasmic reticulum, score: 9 YP_001588327.1 KEGG: eci:UTI89_C0678 9.0e-20 hypothetical protein K01186; COG: COG4692 Predicted neuraminidase (sialidase); Psort location: cytoplasmic, score: 23 YP_001588328.1 COG: COG0071 Molecular chaperone (small heat shock protein); Psort location: cytoplasmic, score: 23 YP_001588329.1 COG: NOG30976 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588330.1 Psort location: nuclear, score: 23 YP_001588331.1 COG: NOG33500 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001588332.1 Psort location: cytoplasmic, score: 23 YP_001588333.1 PliC; periplasmic lysozyme inhibitor of c-type lysozyme YP_001588334.1 Psort location: nuclear, score: 23 YP_001588335.1 Psort location: cytoplasmic, score: 23 YP_001588336.1 Psort location: nuclear, score: 23 YP_001588337.1 COG: NOG33614 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588338.1 COG: COG3637 Opacity protein and related surface antigens; Psort location: endoplasmic reticulum, score: 9 YP_001588339.1 Psort location: nuclear, score: 23 YP_001588340.1 COG: NOG33321 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588341.1 COG: NOG30737 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001588342.1 COG: COG1278 Cold shock proteins; Psort location: nuclear, score: 23 YP_001588343.1 Psort location: mitochondrial, score: 23 YP_001588344.1 Psort location: mitochondrial, score: 23 YP_001588345.1 KEGG: sde:Sde_3710 9.6e-08 arabinogalactan endo-1,4-beta-galactosidase K01224; COG: NOG25721 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001588346.1 COG: NOG15335 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588347.1 Psort location: endoplasmic reticulum, score: 9 YP_001588348.1 Psort location: endoplasmic reticulum, score: 9 YP_001588349.1 Psort location: mitochondrial, score: 23 YP_001588350.1 Psort location: cytoplasmic, score: 23 YP_001588351.1 COG: NOG36734 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001588352.1 COG: COG1943 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001588353.1 Psort location: cytoplasmic, score: 23 YP_001588354.1 KEGG: sty:STY1278 2.6e-24 icdA; isocitrate dehydrogenase K00031; COG: COG0538 Isocitrate dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001588355.1 Psort location: endoplasmic reticulum, score: 9 YP_001588356.1 COG: COG2135 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001588357.1 KEGG: ypn:YPN_0750 2.1e-83 extracellular solute-binding protein K01713; COG: COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; Psort location: extracellular, including cell wall, score: 9 YP_001588358.1 Psort location: cytoplasmic, score: 23 YP_001588359.1 Psort location: cytoplasmic, score: 23 YP_001588360.1 Psort location: cytoplasmic, score: 23 YP_001588361.1 COG: NOG20650 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588362.1 COG: COG5301 Phage-related tail fibre protein; Psort location: cytoplasmic, score: 23 YP_001588363.1 COG: COG3778 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001588364.1 COG: COG3299 Uncharacterized homolog of phage Mu protein gp47; Psort location: cytoplasmic, score: 23 YP_001588365.1 COG: COG4381 Mu-like prophage protein gp46; Psort location: cytoplasmic, score: 23 YP_001588366.1 COG: COG4384 Mu-like prophage protein gp45; Psort location: cytoplasmic, score: 23 YP_001588367.1 COG: COG4379 Mu-like prophage tail protein gpP; Psort location: cytoplasmic, score: 23 YP_001588368.1 COG: COG4228 Mu-like prophage DNA circulation protein; Psort location: cytoplasmic, score: 23 YP_001588369.1 COG: COG5283 Phage-related tail protein; Psort location: endoplasmic reticulum, score: 9 YP_001588370.1 COG: NOG22112 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588371.1 COG: NOG11333 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588372.1 COG: COG4386 Mu-like prophage tail sheath protein gpL; Psort location: cytoplasmic, score: 23 YP_001588373.1 Psort location: nuclear, score: 23 YP_001588374.1 COG: NOG22114 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588375.1 COG: NOG30834 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001588376.1 COG: NOG32857 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588377.1 COG: NOG24115 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588378.1 Psort location: nuclear, score: 23 YP_001588379.1 COG: COG4653 Predicted phage phi-C31 gp36 major capsid-like protein; Psort location: cytoplasmic, score: 23 YP_001588380.1 KEGG: mtu:Rv2651c 0.00088 possible phiRv2 prophage protease; COG: COG3740 Phage head maturation protease; Psort location: cytoplasmic, score: 23 YP_001588381.1 COG: COG4695 Phage-related protein; Psort location: cytoplasmic, score: 23 YP_001588382.1 COG: NOG39002 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001588383.1 COG: COG4626 Phage terminase-like protein, large subunit; Psort location: mitochondrial, score: 23 YP_001588384.1 COG: COG3747 Phage terminase, small subunit; Psort location: nuclear, score: 23 YP_001588385.1 Psort location: mitochondrial, score: 23 YP_001588386.1 Psort location: cytoplasmic, score: 23 YP_001588387.1 Psort location: endoplasmic reticulum, score: 9 YP_001588388.1 KEGG: mxa:MXAN_4534 1.2e-05 chitinase, class I K01183; COG: COG3179 Predicted chitinase; Psort location: cytoplasmic, score: 23 YP_001588389.1 COG: NOG19594 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588390.1 Psort location: nuclear, score: 23 YP_001588391.1 COG: NOG09845 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588392.1 COG: NOG14016 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001588393.1 Psort location: cytoplasmic, score: 23 YP_001588394.1 COG: NOG06198 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588395.1 Psort location: nuclear, score: 23 YP_001588396.1 COG: NOG18526 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001588397.1 Psort location: nuclear, score: 23 YP_001588398.1 Psort location: cytoplasmic, score: 23 YP_001588399.1 COG: NOG12160 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588400.1 Psort location: cytoplasmic, score: 23 YP_001588401.1 COG: NOG27404 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588402.1 COG: NOG29340 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588403.1 KEGG: spi:MGAS10750_Spy1680 4.1e-10 replicative DNA helicase K01529; COG: COG1484 DNA replication protein; Psort location: cytoplasmic, score: 23 YP_001588404.1 COG: COG3756 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001588405.1 KEGG: bcz:BCZK4216 0.0093 clpX; ATP-dependent Clp protease, ATP-binding subunit K03544; Psort location: cytoplasmic, score: 23 YP_001588406.1 COG: NOG24659 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588407.1 COG: COG3381 Uncharacterized component of anaerobic dehydrogenases; Psort location: nuclear, score: 23 YP_001588408.1 COG: NOG36342 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001588409.1 COG: NOG36342 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001588410.1 Psort location: mitochondrial, score: 23 YP_001588411.1 COG: NOG36471 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001588412.1 KEGG: sty:STY2073 1.9e-160 recE; exodeoxyribonuclease VIII K01146; COG: NOG06785 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588413.1 COG: NOG11393 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588414.1 COG: NOG30287 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588415.1 Psort location: cytoplasmic, score: 23 YP_001588416.1 COG: NOG18529 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001588417.1 COG: COG0582 Integrase; Psort location: cytoplasmic, score: 23 YP_001588418.1 COG: NOG31283 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588419.1 Psort location: nuclear, score: 23 YP_001588420.1 Psort location: nuclear, score: 23 YP_001588421.1 Psort location: mitochondrial, score: 23 YP_001588422.1 KEGG: ypn:YPN_0750 2.1e-83 extracellular solute-binding protein K01713; COG: COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; Psort location: extracellular, including cell wall, score: 9 YP_001588423.1 Psort location: cytoplasmic, score: 23 YP_001588424.1 Psort location: cytoplasmic, score: 23 YP_001588425.1 Psort location: extracellular, including cell wall, score: 9 YP_001588426.1 COG: NOG20650 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588427.1 COG: COG5301 Phage-related tail fibre protein; Psort location: cytoplasmic, score: 23 YP_001588428.1 COG: NOG11442 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588429.1 KEGG: chu:CHU_0841 0.00093 CHU large protein; uncharacterized K01238; COG: COG3299 Uncharacterized homolog of phage Mu protein gp47; Psort location: cytoplasmic, score: 23 YP_001588430.1 COG: NOG14123 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588431.1 COG: NOG14673 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588432.1 Psort location: nuclear, score: 23 YP_001588433.1 Psort location: cytoplasmic, score: 23 YP_001588434.1 Psort location: cytoplasmic, score: 23 YP_001588435.1 COG: NOG29947 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001588436.1 COG: NOG10016 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588437.1 COG: NOG19596 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588438.1 COG: NOG11443 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001588439.1 KEGG: bxe:Bxe_B2926 1.3e-16 putative transglycolase K01238; COG: NOG17187 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001588440.1 COG: NOG27862 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588441.1 COG: NOG11444 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588442.1 COG: NOG06286 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001588443.1 COG: NOG11445 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 23 YP_001588444.1 COG: NOG28542 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588445.1 COG: NOG18525 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001588446.1 COG: NOG12166 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588447.1 COG: NOG29211 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001588448.1 COG: COG4834 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001588449.1 COG: NOG11446 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588450.1 COG: COG3566 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001588451.1 COG: COG2369 Uncharacterized protein, homolog of phage Mu protein gp30; Psort location: cytoplasmic, score: 23 YP_001588452.1 Psort location: cytoplasmic, score: 23 YP_001588453.1 COG: COG3567 Uncharacterized protein conserved in bacteria; Psort location: mitochondrial, score: 23 YP_001588454.1 COG: COG1783 Phage terminase large subunit; Psort location: cytoplasmic, score: 23 YP_001588455.1 COG: NOG06766 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001588456.1 COG: NOG31488 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001588457.1 COG: NOG23010 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588458.1 KEGG: stm:STM0908 0.00053 Fels-1 prophage K01423; COG: NOG11447 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001588459.1 KEGG: cvi:CV0024 1.8e-07 probable hydroxyethylTHIazole kinase K00878; COG: COG3179 Predicted chitinase; Psort location: cytoplasmic, score: 23 YP_001588460.1 COG: NOG23011 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001588461.1 COG: NOG37752 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001588462.1 COG: NOG26958 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001588463.1 Psort location: nuclear, score: 23 YP_001588464.1 Psort location: nuclear, score: 23 YP_001588465.1 COG: NOG09845 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588466.1 Psort location: cytoplasmic, score: 23 YP_001588467.1 COG: NOG14016 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588468.1 Psort location: cytoplasmic, score: 23 YP_001588469.1 COG: NOG06198 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588470.1 COG: NOG29483 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588471.1 Psort location: cytoplasmic, score: 23 YP_001588472.1 COG: NOG25762 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001588473.1 Psort location: cytoplasmic, score: 23 YP_001588474.1 COG: NOG12173 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001588475.1 Psort location: cytoplasmic, score: 23 YP_001588476.1 COG: COG5529 Pyocin large subunit; Psort location: cytoplasmic, score: 23 YP_001588477.1 Psort location: nuclear, score: 23 YP_001588478.1 KEGG: spr:spr0448 0.0060 hsdS; type I site-specific deoxyribonuclease chain S K01152; COG: NOG36342 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001588479.1 Psort location: nuclear, score: 23 YP_001588480.1 COG: NOG35289 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588481.1 Psort location: cytoplasmic, score: 23 YP_001588482.1 COG: NOG36471 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001588483.1 Psort location: cytoplasmic, score: 23 YP_001588484.1 Psort location: mitochondrial, score: 23 YP_001588485.1 The RecE (also known as exonuclease VIII) pathway is an alternative pathway for the initiation of homologous recombination in Escherichia coli. The RecE pathway is activated in recB, recC sbcA (suppressors of recB and recC) mutants. Activation of the RecE pathway results in the production of at least two phage proteins relevant for recombinational repair. RecE is a duplex DNA-specific exonuclease which produces 3' overhangs in duplex DNA by preferentially degrading the 5'-ending strands. Recombinational repair of E.coli chromosomal DNA involves as well other proteins: RecA, RecF, RecJ, RecO, RecR, and RuvC. YP_001588486.1 COG: COG3723 Recombinational DNA repair protein (RecE pathway); Psort location: cytoplasmic, score: 23 YP_001588487.1 Psort location: cytoplasmic, score: 23 YP_001588488.1 Psort location: nuclear, score: 23 YP_001588489.1 COG: NOG22010 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588490.1 Psort location: cytoplasmic, score: 23 YP_001588491.1 COG: COG0582 Integrase; Psort location: nuclear, score: 23 YP_001588492.1 Converts isocitrate to alpha ketoglutarate YP_001588493.1 KEGG: stm:STM1237 1.2e-117 ymfC; putative ribosomal large subunit pseudouridine synthase K06181; COG: COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases; Psort location: nuclear, score: 23 YP_001588494.1 COG: COG4461 Uncharacterized protein conserved in bacteria, putative lipoprotein; Psort location: mitochondrial, score: 23 YP_001588495.1 KEGG: sec:SC1186 3.1e-82 ymfB; putative MutT-like protein; COG: COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Psort location: cytoplasmic, score: 23 YP_001588496.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_001588497.1 HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis YP_001588498.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_001588499.1 response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress YP_001588500.1 KEGG: spt:SPA1620 1.8e-258 phoQ; sensor protein PhoQ, regulator of virulence determinants K07637; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 9 YP_001588501.1 COG: COG2850 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001588502.1 COG: COG0457 FOG: TPR repeat; Psort location: mitochondrial, score: 23 YP_001588503.1 catalyzes the release of the N-terminal amino acid from a tripeptide YP_001588504.1 Psort location: nuclear, score: 23 YP_001588505.1 functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase YP_001588506.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component YP_001588507.1 Psort location: mitochondrial, score: 23 YP_001588508.1 translocated by the type III secretion system SPI-2; required for the formation of lysosomal glycoprotein structures (Sifs); required for maintenance of membrane in the Salmonella-containing vacuole; a cysteine residue with CAAX motif is modified by isoprenoid addition of protein geranylgeranyl transferase I; also modified by S-acylation YP_001588509.1 Psort location: cytoplasmic, score: 23 YP_001588510.1 Psort location: cytoplasmic, score: 23 YP_001588511.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component YP_001588512.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotD is a periplasmic component that binds the substrate YP_001588513.1 Modulates the activities of several enzymes which are inactive in their acetylated form YP_001588514.1 catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine YP_001588515.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane YP_001588516.1 outer membrane specific; part of transporter complex lolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone YP_001588517.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane YP_001588518.1 Psort location: mitochondrial, score: 23 YP_001588519.1 KEGG: eci:UTI89_C1242 0. mfd; transcription-repair coupling factor; mutation frequency decline K03723; COG: COG1197 Transcription-repair coupling factor (superfamily II helicase); Psort location: cytoplasmic, score: 23 YP_001588520.1 Psort location: mitochondrial, score: 23 YP_001588521.1 KEGG: eci:UTI89_C2228 4.9e-68 erfK; hypothetical protein K00257; COG: COG1376 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001588522.1 KEGG: reu:Reut_B4338 0.0024 copper/zinc superoxide dismutase K04565; COG: NOG13874 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001588523.1 COG: COG1309 Transcriptional regulator; Psort location: nuclear, score: 23 YP_001588524.1 COG: COG3134 Predicted outer membrane lipoprotein; Psort location: endoplasmic reticulum, score: 9 YP_001588525.1 KEGG: stt:t1709 1.5e-231 ndh; NADH dehydrogenase K03885; COG: COG1252 NADH dehydrogenase, FAD-containing subunit; Psort location: cytoplasmic, score: 23 YP_001588526.1 COG: COG1943 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001588527.1 Psort location: cytoplasmic, score: 23 YP_001588528.1 COG: COG3150 Predicted esterase; Psort location: cytoplasmic, score: 23 YP_001588529.1 hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides YP_001588530.1 catalyzes the phosphorylation of thiamine to thiamine phosphate YP_001588531.1 COG: COG3417 Collagen-binding surface adhesin SpaP (antigen I/II family); Psort location: extracellular, including cell wall, score: 9 YP_001588532.1 COG: COG5633 Predicted periplasmic lipoprotein; Psort location: extracellular, including cell wall, score: 9 YP_001588533.1 KEGG: eci:UTI89_C1231 1.2e-57 ycfF; HIT-like protein YcfF K01518; COG: COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases; Psort location: cytoplasmic, score: 23 YP_001588534.1 COG: COG4773 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid; Psort location: endoplasmic reticulum, score: 9 YP_001588535.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_001588536.1 Psort location: cytoplasmic, score: 23 YP_001588537.1 KEGG: stm:STM1202 8.6e-126 ycfH; putative deoxyribonuclease K03424; COG: COG0084 Mg-dependent DNase; Psort location: cytoplasmic, score: 23 YP_001588538.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA YP_001588539.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) YP_001588540.1 KEGG: eci:UTI89_C1224 1.6e-158 yceG; putative thymidylate kinase; COG: COG1559 Predicted periplasmic solute-binding protein; Psort location: extracellular, including cell wall, score: 23 YP_001588541.1 catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate YP_001588542.2 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_001588543.1 carries the fatty acid chain in fatty acid biosynthesis YP_001588544.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_001588545.1 KEGG: stm:STM1194 9.2e-161 fabD; malonyl-CoA-[acyl-carrier-protein] transacylase K00645; COG: COG0331 (acyl-carrier-protein) S-malonyltransferase; Psort location: cytoplasmic, score: 23 YP_001588546.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs YP_001588547.1 KEGG: azo:azo1622 1.3e-49 plsX; probable fatty acid/phospholipid synthesis protein PlsX; COG: COG0416 Fatty acid/phospholipid biosynthesis enzyme; Psort location: cytoplasmic, score: 23 YP_001588548.1 Psort location: cytoplasmic, score: 23 YP_001588549.1 COG: COG1399 Predicted metal-binding, possibly nucleic acid-binding protein; Psort location: cytoplasmic, score: 23 YP_001588550.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell YP_001588551.1 Psort location: cytoplasmic, score: 23 YP_001588552.1 COG: NOG06217 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588553.1 catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA YP_001588554.1 Psort location: cytoplasmic, score: 23 YP_001588555.1 bifunctional ribonuclease E/endoribonuclease/RNA-binding protein/RNA degradosome binding protein; forms part of the membrane-associated degradosome complex along with PNPase, RhlB, and enolase YP_001588556.1 Psort location: mitochondrial, score: 23 YP_001588557.1 with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes YP_001588558.1 with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook YP_001588559.1 Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space YP_001588560.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum YP_001588561.1 part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod YP_001588562.1 Psort location: nuclear, score: 23 YP_001588563.1 makes up the distal portion of the flagellar basal body rod YP_001588564.1 FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod YP_001588565.1 the hook connects flagellar basal body to the flagellar filament YP_001588566.1 acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production YP_001588567.1 with FlgF and B makes up the proximal portion of the flagellar basal body rod YP_001588568.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella YP_001588569.1 Psort location: mitochondrial, score: 23 YP_001588570.1 required for the assembly of the flagellar basal body P-ring YP_001588571.1 Psort location: cytoplasmic, score: 23 YP_001588572.1 regulates the flagellar specific sigma28 transcription factor YP_001588573.1 COG: COG3418 Flagellar biosynthesis/type III secretory pathway chaperone; Psort location: nuclear, score: 23 YP_001588574.1 COG: COG0728 Uncharacterized membrane protein, putative virulence factor; Psort location: plasma membrane, score: 23 YP_001588575.1 KEGG: lpl:lp_0813 2.9e-31 oxidoreductase (putative) K03810; COG: COG0673 Predicted dehydrogenases and related proteins; Psort location: cytoplasmic, score: 23 YP_001588576.1 COG: COG3132 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001588577.1 KEGG: sec:SC1115 1.0e-106 rimJ; acetylation of N-terminal alanine of 30S ribosomal subunit protein S5 K03790; COG: COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins; Psort location: cytoplasmic, score: 23 YP_001588578.1 Confers resistance to norfloxacin and enoxacin YP_001588579.1 cofactor involved in the reduction of disulfides YP_001588580.1 COG: NOG07875 non supervised orthologous group; Psort location: nuclear, score: 23; ORF located using Blastx YP_001588581.1 COG: NOG07875 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001588582.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis YP_001588583.1 COG: NOG13873 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588584.1 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing YP_001588585.1 catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids YP_001588586.1 Psort location: nuclear, score: 23 YP_001588587.1 Psort location: nuclear, score: 23 YP_001588588.1 KEGG: reh:H16_A3123 2.7e-26 cytochrome b561 K00156; COG: COG3038 Cytochrome B561; Psort location: endoplasmic reticulum, score: 9 YP_001588589.1 COG: COG2353 Uncharacterized conserved protein; Psort location: extracellular, including cell wall, score: 9 YP_001588590.1 KEGG: pub:SAR11_1074 8.6e-23 yceA; rhodanese domain protein; COG: COG1054 Predicted sulfurtransferase; Psort location: cytoplasmic, score: 23 YP_001588591.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA YP_001588592.1 Confers resistance to fosfomycin and deoxycholate YP_001588593.1 COG: NOG09842 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588594.1 COG: COG5645 Predicted periplasmic lipoprotein; Psort location: endoplasmic reticulum, score: 9 YP_001588595.1 necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space YP_001588596.1 involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan YP_001588597.1 Psort location: mitochondrial, score: 23 YP_001588598.1 required for the transfer of succinyl residues to the glucan backbone YP_001588599.1 KEGG: reh:H16_B1107 1.0e-115 phospholipase D K01115; COG: COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipi n synthases and related enzymes; Psort location: mitochondrial, score: 23 YP_001588600.1 KEGG: reh:H16_A1552 1.2e-46 predicted phosphatase homolog to the C-terminal domain of histone macroH2A1; COG: COG2110 Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1; Psort location: cytoplasmic, score: 23 YP_001588601.1 COG: NOG18522 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_002633100.1 involved in autoagglutination of curliated cells; not involved in production of curli fibers YP_001588603.1 COG: NOG09021 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001588604.1 CsgB; functions as a nucleator in the assembly of curli (coiled surface structures) on the cell surface YP_001588605.1 Psort location: nuclear, score: 23 YP_001588606.1 Psort location: cytoplasmic, score: 23 YP_001588607.1 Psort location: nuclear, score: 23 YP_001588608.1 Psort location: cytoplasmic, score: 23 YP_001588609.1 activates the csgBA and csgDEFG operons involved in biofilm formation YP_001588610.1 chaperone-like protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex YP_001588611.1 nucleator protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex YP_001588612.1 COG: COG1462 Uncharacterized protein involved in formation of curli polymers; Psort location: endoplasmic reticulum, score: 9 YP_001588613.1 COG: NOG09737 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001588614.1 KEGG: vfi:VFA0083 3.2e-09 ynfI; anaerobic dimethyl sulfoxide reductase chain YnfI K00397; COG: COG3381 Uncharacterized component of anaerobic dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001588615.1 KEGG: eci:UTI89_C1155 1.7e-120 ycdX; hypothetical protein K04477; COG: COG1387 Histidinol phosphatase and related hydrolases of the PHP family; Psort location: cytoplasmic, score: 23 YP_001588616.1 KEGG: eco:b1033 5.0e-137 ycdW; 2-ketoacid reductase K00049; COG: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001588617.1 Psort location: cytoplasmic, score: 23 YP_001588618.1 Psort location: cytoplasmic, score: 23 YP_001588619.1 KEGG: eco:b4280 5.7e-129 yjhC; KpLE2 phage-like element; predicted oxidoreductase; COG: COG0673 Predicted dehydrogenases and related proteins; Psort location: cytoplasmic, score: 23 YP_001588620.1 KEGG: cal:orf19.2425 2.1e-07 highly conserved hypothetical protein K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001588621.1 COG: NOG06222 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 23 YP_001588622.1 COG: COG3055 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001588623.1 Psort location: cytoplasmic, score: 23 YP_001588624.1 Psort location: mitochondrial, score: 23 YP_001588625.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate YP_001588626.1 Psort location: nuclear, score: 23 YP_001588627.1 Psort location: cytoplasmic, score: 23 YP_001588628.1 KEGG: rpr:RP465 3.3e-08 phoR; alkaline phosphatase synthesis sensor protein phoR K07636; COG: COG0591 Na+/proline symporter; Psort location: plasma membrane, score: 23 YP_001588629.1 Psort location: mitochondrial, score: 23 YP_001588630.1 KEGG: bte:BTH_I1550 2.3e-28 glucokinase/transcriptional regulator, RpiR family, fusion K00845; COG: COG1737 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001588631.1 KEGG: reh:H16_A0527 1.7e-42 phoH; phosphate starvation-inducible protein PhoH,predicted ATPase; COG: COG1702 Phosphate starvation-inducible protein PhoH, predicted ATPase; Psort location: cytoplasmic, score: 23 YP_001588632.1 Psort location: cytoplasmic, score: 23 YP_001588633.1 Psort location: mitochondrial, score: 23 YP_001588634.1 KEGG: rde:RD1_2839 8.5e-08 sensor histidine kinase, putative; COG: COG0591 Na+/proline symporter; Psort location: plasma membrane, score: 23 YP_001588635.1 Psort location: cytoplasmic, score: 23 YP_001588636.1 Psort location: cytoplasmic, score: 23 YP_001588637.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichai coli this protein also self-regulates transcription via a DNA-binding domain at the N-terminus; forms dimers and is a peripherally membrane-associated protein YP_001588638.1 COG: COG3755 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001588639.1 KEGG: bcl:ABC2937 0.0040 NADH dehydrogenase K03885; COG: COG1309 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001588640.1 Psort location: cytoplasmic, score: 23 YP_001588641.1 Psort location: mitochondrial, score: 23 YP_001588642.1 Psort location: mitochondrial, score: 23 YP_001588643.1 Psort location: cytoplasmic, score: 23 YP_001588644.1 stationary phase protein that binds TrpR repressor YP_001588645.1 COG: NOG13872 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588646.1 KEGG: stm:STM1117 1.5e-224 agp; glucose-1-phosphatase K01085; COG: NOG06770 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001588647.1 KEGG: ava:Ava_4761 1.5e-09 THIoredoxin K03671; COG: COG0526 Thiol-disulfide isomerase and THIoredoxins; Psort location: endoplasmic reticulum, score: 9 YP_001588648.1 KEGG: azo:azo0382 2.1e-05 dsbA; putative protein disulfide-isomerase K01829; COG: COG1651 Protein-disulfide isomerase; Psort location: extracellular, including cell wall, score: 9 YP_001588649.1 KEGG: xcc:XCC0519 6.5e-54 dsbD; c-type cytochrome biogenesis protein K04084; COG: COG4233 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis; Psort location: endoplasmic reticulum, score: 9 YP_001588650.1 COG: NOG29928 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588651.1 Psort location: mitochondrial, score: 23 YP_001588652.1 functional analog of DnaJ; co-chaperone with DnaK, molecular chaperone in an adaptive response to environmental stresses other than heat shock YP_001588653.1 with CpbA modulates the activity of the dnaK chaperone system; interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA YP_001588654.1 Psort location: cytoplasmic, score: 23 YP_001588655.1 Psort location: cytoplasmic, score: 23 YP_001588656.1 Psort location: nuclear, score: 23 YP_001588657.1 KEGG: aha:AHA_1197 3.0e-29 ribonuclease Z, putative K00784; COG: COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III; Psort location: extracellular, including cell wall, score: 9 YP_001588658.1 KEGG: bli:BL05281 1.1e-06 adaA; methylphosphotriester-DNA alkyltransferase and transcriptional regulator (AraC/XylS family) K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001588659.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001588660.1 KEGG: sty:STY1140 5.8e-136 hpcH, hpaI; 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase K02510; COG: COG3836 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Psort location: cytoplasmic, score: 23 YP_001588661.1 KEGG: sty:STY1139 5.3e-142 hpcG; 2-oxo-hepta-3-ene-1,7-dioic acid hydratase K02509; COG: COG3971 2-keto-4-pentenoate hydratase; Psort location: cytoplasmic, score: 23 YP_001588662.1 Psort location: cytoplasmic, score: 23 YP_001588663.1 KEGG: sec:SC1054 3.5e-65 hpaF; 4-hydroxyphenylacetate catabolism K01826; COG: COG3232 5-carboxymethyl-2-hydroxymuconate isomerase; Psort location: cytoplasmic, score: 23 YP_001588664.1 KEGG: stm:STM1103 8.8e-156 hpaD; 4-hydroxyphenylacetate catabolism K00455; COG: COG3384 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001588665.1 KEGG: stm:STM1102 1.9e-263 hpaE; 4-hydroxyphenylacetate catabolism K00151; COG: COG1012 NAD-dependent aldehyde dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001588666.1 KEGG: stt:t1818 4.6e-230 hpaG; 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase / 5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase K05921; COG: COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway); Psort location: cytoplasmic, score: 23 YP_001588667.1 COG: COG1846 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001588668.1 KEGG: stm:STM1099 5.0e-288 hpaB; 4-hydroxyphenylacetate catabolism K00483; COG: COG2368 Aromatic ring hydroxylase; Psort location: cytoplasmic, score: 23 YP_001588669.1 KEGG: spt:SPA1752 4.0e-89 hpaC; 4-hydroxyphenylacetate 3-monooxygenase coupling protein K00484; COG: COG1853 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family; Psort location: cytoplasmic, score: 23 YP_001588670.1 Psort location: mitochondrial, score: 23 YP_001588671.1 Psort location: nuclear, score: 23 YP_001588672.1 KEGG: gbe:GbCGDNIH1_1243 7.9e-13 urate oxidase K00365; COG: COG2351 Transthyretin-like protein; Psort location: extracellular, including cell wall, score: 9 YP_001588673.1 induced by CusR in the presence of copper; YedW induces the expression of the upstream gene yedV (encoding a sensor kinase) as well as yedW; yedVW is one of four copper regulons found in E. coli; part of the copper homeostasis mechanism; confers resistance to copper and several drugs when induced YP_001588674.1 KEGG: sec:SC1045 1.0e-234 copS; copper resistance; histidine kinase K07644; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 9 YP_001588675.1 KEGG: lsa:LSA0897 1.2e-71 pepD5; dipeptidase D-type (U34 family) K01274; COG: COG4690 Dipeptidase; Psort location: endoplasmic reticulum, score: 9 YP_001588676.1 Psort location: extracellular, including cell wall, score: 23 YP_001588677.1 COG: NOG34864 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001588678.1 COG: NOG06178 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001588679.1 COG: NOG09749 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588680.1 Psort location: nuclear, score: 23 YP_001588681.1 KEGG: ava:Ava_4923 6.9e-08 serine/threonine protein kinase K08884; COG: COG1357 Uncharacterized low-complexity proteins; Psort location: cytoplasmic, score: 23 YP_001588682.1 COG: NOG26051 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588683.1 Psort location: cytoplasmic, score: 23 YP_001588684.1 COG: COG0670 Integral membrane protein, interacts with FtsH; Psort location: endoplasmic reticulum, score: 9 YP_001588685.1 transfers sulfur from TusBCD complex to MnmA; involved in thiouridation of U34 position of some tRNAs YP_001588686.1 catalyzes the hydrolysis of acylphosphate YP_001588687.1 KEGG: pol:Bpro_1638 0.0017 transcriptional regulator, AraC family K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: nuclear, score: 23 YP_001588688.1 COG: COG1881 Phospholipid-binding protein; Psort location: extracellular, including cell wall, score: 9 YP_001588689.1 Psort location: cytoplasmic, score: 23 YP_001588690.1 KEGG: eci:UTI89_C1034 7.5e-198 yccW; hypothetical protein YccW K06969; COG: COG1092 Predicted SAM-dependent methyltransferases; Psort location: vesicles of secretory system, score: 9 YP_001588691.1 COG: COG3785 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001588692.1 KEGG: rru:Rru_A2075 9.5e-30 O-acetylhomoserine/O-acetylserine sulfhydrylase K01740; COG: COG1832 Predicted CoA-binding protein; Psort location: cytoplasmic, score: 23 YP_001588693.1 COG: COG3110 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001588694.1 catalyzes the formation of methylglyoxal from glycerone phosphate YP_001588695.1 catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand YP_001588696.1 COG: COG3304 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001588697.1 KEGG: eco:b3358 6.6e-30 yhfK; conserved inner membrane protein K01823; COG: COG1289 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001588698.1 COG: COG3070 Regulator of competence-specific genes; Psort location: cytoplasmic, score: 23 YP_001588699.1 Psort location: nuclear, score: 23 YP_001588700.1 COG: COG5404 SOS-response cell division inhibitor, blocks FtsZ ring formation; Psort location: extracellular, including cell wall, score: 9 YP_001588701.1 OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d YP_001588702.1 COG: COG3120 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001588703.1 KEGG: spt:SPA1782 0. lonH; Lon-like ATP-dependent protease K04770; COG: COG1067 Predicted ATP-dependent protease; Psort location: cytoplasmic, score: 23 YP_001588704.1 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP YP_001588705.1 Psort location: cytoplasmic, score: 23 YP_001588706.1 COG: COG3009 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001588707.1 COG: COG3008 Paraquat-inducible protein B; Psort location: endoplasmic reticulum, score: 9 YP_001588708.1 COG: COG2995 Uncharacterized paraquat-inducible protein A; Psort location: plasma membrane, score: 23 YP_001588709.1 Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth YP_001588710.1 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA YP_001588711.1 KEGG: eci:UTI89_C0875 2.0e-05 hcr; NADH oxidoreductase; COG: COG0633 Ferredoxin; Psort location: mitochondrial, score: 23 YP_001588712.1 COG: NOG07913 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588713.1 Psort location: nuclear, score: 23 YP_001588714.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors YP_001588715.1 KEGG: stm:STM1057 0. pepN; aminopeptidase N K01256; COG: COG0308 Aminopeptidase N; Psort location: cytoplasmic, score: 23 YP_001588716.1 catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate YP_001588717.1 KEGG: hpa:HPAG1_0925 1.1e-59 D-alanine glycine permease K01613; COG: COG1115 Na+/alanine symporter; Psort location: plasma membrane, score: 23 YP_001588718.1 Psort location: cytoplasmic, score: 23 YP_001588719.1 catalyzes the formation of pyruvate from 2,3-diaminopropionate YP_001588720.1 Psort location: cytoplasmic, score: 23 YP_001588721.1 Psort location: endoplasmic reticulum, score: 9 YP_001588722.1 COG: COG1522 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001588723.1 Psort location: nuclear, score: 23 YP_001588724.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001588725.1 Psort location: nuclear, score: 23 YP_001588726.1 COG: COG3203 Outer membrane protein (porin); Psort location: extracellular, including cell wall, score: 9 YP_001588727.1 Psort location: cytoplasmic, score: 23 YP_001588728.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate YP_001588729.1 KEGG: eci:UTI89_C0999 1.7e-111 ycbL; hypothetical protein K01069; COG: COG0491 Zn-dependent hydrolases, including glyoxylases; Psort location: extracellular, including cell wall, score: 9 YP_001588730.1 COG: COG3108 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001588731.1 KEGG: fal:FRAAL6874 0.00034 amiB; N-acetymuramyl-L-alanine amidase K01448; COG: COG2989 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001588732.1 SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects YP_001588733.1 acts with MukB and MukF to condense the chromosome and allow for segregation during cell division YP_001588734.1 acts with MukB and MukE to condense the chromosome and allow for segregation during cell division YP_001588735.1 involved in cellular zinc and cadmium homeostasis by binding excess metal ions to its cysteine sulfurs and histidine nitrogens; expression of smtA in cyanobacteria is repressed by SmtB at low concentrations of zinc; NO elicits release of Zn ions from SmtA YP_001588736.1 COG: COG1434 Uncharacterized conserved protein; Psort location: extracellular, including cell wall, score: 9 YP_001588737.1 COG: NOG06195 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588738.1 Psort location: nuclear, score: 23 YP_001588739.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS YP_001588740.1 KEGG: net:Neut_2110 1.5e-14 tetraacyldisaccharide 4'-kinase K00912; COG: COG2835 Uncharacterized conserved protein; Psort location: nuclear, score: 23 YP_001588741.1 COG: COG3214 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001588742.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate YP_001588743.1 involved in the transport of lipid A across the inner membrane YP_001588744.1 COG: COG0658 Predicted membrane metal-binding protein; Psort location: plasma membrane, score: 23 YP_001588745.1 Psort location: nuclear, score: 23 YP_001588746.1 Psort location: cytoplasmic, score: 23 YP_001588747.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_001588748.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_001588749.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP YP_001588750.1 KEGG: sec:SC0933 7.3e-129 ycaL; putative Zn-dependent protease with chaperone function K07387; COG: COG0501 Zn-dependent protease with chaperone function; Psort location: extracellular, including cell wall, score: 9 YP_001588751.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_001588752.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine YP_001588753.1 Psort location: nuclear, score: 23 YP_001588754.1 COG: COG2323 Predicted membrane protein; Psort location: cytoplasmic, score: 23 YP_001588755.1 Psort location: cytoplasmic, score: 23 YP_001588756.1 COG: COG1944 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001588757.1 KEGG: shn:Shewana3_1556 1.1e-75 meTHIonine gamma-lyase K01761; COG: COG2116 Formate/nitrite family of transporters; Psort location: endoplasmic reticulum, score: 9 YP_001588758.1 KEGG: stm:STM0973 0. pflB; pyruvate formate lyase I K00656; COG: COG1882 Pyruvate-formate lyase; Psort location: cytoplasmic, score: 23 YP_001588759.1 COG: NOG25864 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588760.1 Psort location: mitochondrial, score: 23 YP_001588761.1 Psort location: cytoplasmic, score: 23 YP_001588762.1 Psort location: cytoplasmic, score: 23 YP_001588763.1 KEGG: sec:SC0924 1.4e-118 pflA; pyruvate formate lyase activating enzyme 1 K04069; COG: COG1180 Pyruvate-formate lyase-activating enzyme; Psort location: cytoplasmic, score: 23 YP_001588764.1 KEGG: eci:UTI89_C0120 2.8e-10 aroP; aromatic amino acid transport protein AroP K03293; COG: COG0531 Amino acid transporters; Psort location: plasma membrane, score: 23 YP_001588765.1 KEGG: eci:UTI89_C5041 1.4e-07 yjiJ; hypothetical protein YjiJ K00403; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001588766.1 Psort location: nuclear, score: 23 YP_001588767.1 Psort location: nuclear, score: 23 YP_001588768.1 KEGG: ecp:ECP_0910 3.8e-139 anaerobic dimethyl sulfoxide reductase, subunit C K07308; COG: COG3302 DMSO reductase anchor subunit; Psort location: plasma membrane, score: 23 YP_001588769.1 KEGG: ecp:ECP_0909 1.0e-115 anaerobic dimethyl sulfoxide reductase, subunit B K07307; COG: COG0437 Fe-S-cluster-containing hydrogenase components 1; Psort location: nuclear, score: 23 YP_001588770.1 KEGG: stm:STM0964 0. dmsA; anaerobic dimethyl sulfoxide reductase, subunit A K07306; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: cytoplasmic, score: 23 YP_001588771.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001588772.1 Psort location: cytoplasmic, score: 23 YP_001588773.1 KEGG: pha:PSHAa1714 2.2e-143 rarA; polynucleotide enzyme with nucleotide triphosphate hydrolase domain K07478; COG: COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase; Psort location: cytoplasmic, score: 23 YP_001588774.1 participates with LolB in the incorporation of lipoprotein into the outer membrane YP_001588775.1 DNA-binding membrane protein required for chromosome resolution and partitioning YP_001588776.1 mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system YP_001588777.1 catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding YP_001588778.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c YP_001588779.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c YP_001588780.1 leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys YP_001588781.1 Psort location: nuclear, score: 23 YP_001588782.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_001588783.1 Psort location: mitochondrial, score: 23 YP_001588784.1 KEGG: shn:Shewana3_3435 8.2e-06 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: endoplasmic reticulum, score: 9 YP_001588785.1 KEGG: shn:Shewana3_3385 3.2e-32 hypoxanTHIne phosphoribosyltransferase K00760; COG: COG1741 Pirin-related protein; Psort location: cytoplasmic, score: 23 YP_001588786.1 KEGG: psp:PSPPH_0909 3.2e-48 isochorismatase family protein K05993; COG: COG1335 Amidases related to nicotinamidase; Psort location: endoplasmic reticulum, score: 9 YP_001588787.1 COG: COG0582 Integrase; Psort location: cytoplasmic, score: 23 YP_001588788.1 COG: NOG30969 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001588789.1 ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease; directs protease to specific substrates YP_001588790.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA YP_001588791.1 COG: COG1278 Cold shock proteins; Psort location: cytoplasmic, score: 23 YP_001588792.1 Psort location: nuclear, score: 23 YP_001588793.1 with MacA is involved in the export of macrolide YP_001588794.1 confers macrolide resistance via active drug efflux YP_001588795.1 COG: COG2990 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001588796.1 COG: COG3593 Predicted ATP-dependent endonuclease of the OLD family; Psort location: cytoplasmic, score: 23 YP_001588797.1 Psort location: nuclear, score: 23 YP_001588798.1 COG: COG2431 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 23 YP_001588799.1 catalyzes the reduction of hydroxylamine to ammonia and water YP_001588800.1 KEGG: stm:STM0936 1.9e-176 hcr; NADH oxidoreductase for hcp gene product; COG: COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1; Psort location: cytoplasmic, score: 23 YP_001588801.1 catalyzes the formation of acetate from pyruvate YP_001588802.1 low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine YP_001588803.1 KEGG: eci:UTI89_C0872 2.3e-219 ybjT; hypothetical protein YbjT K00329:K00356; COG: COG0702 Predicted nucleoside-diphosphate-sugar epimerases; Psort location: mitochondrial, score: 23 YP_001588804.1 Psort location: nuclear, score: 23 YP_001588805.1 KEGG: eci:UTI89_C0871 3.3e-172 ybjS; hypothetical protein YbjS K00067; COG: COG0451 Nucleoside-diphosphate-sugar epimerases; Psort location: cytoplasmic, score: 23 YP_001588806.1 KEGG: sty:STY0927 3.8e-148 putative N-acetylmuramoyl-L-alanine amidase K01446; COG: COG3023 Negative regulator of beta-lactamase expression; Psort location: extracellular, including cell wall, score: 9 YP_001588807.1 COG: COG0393 Uncharacterized conserved protein; Psort location: cytoskeletal, score: 9 YP_001588808.1 induced during stationary phase and by acivicin (a glutamine analog); regulated by Lrp and RpoS YP_001588809.1 With ArtMQJI transports arginine across the inner membrane YP_001588810.1 KEGG: eci:UTI89_C2121 1.6e-28 fliY; cystine-binding periplasmic protein precursor K02030:K02424; COG: COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; Psort location: extracellular, including cell wall, score: 9 YP_001588811.1 with ArtPMJI transports arginine across the inner membrane YP_001588812.1 with ArtPQJI acts to transport arginine across the inner membrane YP_001588813.1 KEGG: eci:UTI89_C2121 2.7e-28 fliY; cystine-binding periplasmic protein precursor K02030:K02424; COG: COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; Psort location: extracellular, including cell wall, score: 9 YP_001588814.1 Psort location: mitochondrial, score: 23 YP_001588815.1 KEGG: reh:H16_B1528 4.0e-24 sulfatase; COG: COG3119 Arylsulfatase A and related enzymes; Psort location: cytoplasmic, score: 23 YP_001588816.1 KEGG: stm:STM0885 2.6e-53 putative phosphotransferase enzyme II, B component K02822; COG: COG3414 Phosphotransferase system, galactitol-specific IIB component; Psort location: cytoplasmic, score: 23 YP_001588817.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr YP_001588818.1 COG: NOG35567 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588819.1 RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA YP_001588820.1 KEGG: sma:SAV1319 0.0046 bacA1; undecaprenyl-diphosphatase K06153; COG: NOG08677 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001588821.1 KEGG: cyb:CYB_0398 2.3e-13 modB; molybdate ABC transporter, permease protein K02018; COG: COG1177 ABC-type spermidine/putrescine transport system, permease component II; Psort location: plasma membrane, score: 23 YP_001588822.1 KEGG: hpa:HPAG1_0451 3.6e-08 molybdenum ABC transporter ModB K06022; COG: COG1176 ABC-type spermidine/putrescine transport system, permease component I; Psort location: endoplasmic reticulum, score: 9 YP_001588823.1 part of the PotFGHI ATP-dependent putrescine transporter YP_001588824.1 COG: COG0687 Spermidine/putrescine-binding periplasmic protein; Psort location: endoplasmic reticulum, score: 9 YP_001588825.1 COG: NOG08676 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588826.1 responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 YP_001588827.1 NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds YP_001588828.1 YbjC; located in the same operon as the nfsA gene; member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress; induced by paraquat; regulated by SoxS; unknown function YP_001588829.1 functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase YP_001588830.1 COG: NOG09759 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001588831.1 COG: COG2985 Predicted permease; Psort location: plasma membrane, score: 23 YP_001588832.1 COG: COG3226 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001588833.1 Psort location: cytoplasmic, score: 23 YP_001588834.1 KEGG: pho:PH1451 0.00086 NADH dehydrogenase I chain M K00342; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001588835.1 KEGG: ecp:ECP_0835 4.3e-76 putative hydrolase of the HAD superfamily K07757; COG: COG0561 Predicted hydrolases of the HAD superfamily; Psort location: cytoplasmic, score: 23 YP_001588836.1 KEGG: shn:Shewana3_1692 2.5e-07 Xaa-His dipeptidase K01270; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001588837.1 KEGG: btk:BT9727_2194 1.5e-11 probable phosphatase, PAP2 superfamily; possible bacitracin transport permease K01112; COG: COG0671 Membrane-associated phospholipid phosphatase; Psort location: endoplasmic reticulum, score: 9 YP_001588838.1 COG: COG1349 Transcriptional regulators of sugar metabolism; Psort location: cytoplasmic, score: 23 YP_001588839.1 penicillin-binding protein 6a; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains YP_001588840.1 KEGG: eci:UTI89_C0841 7.8e-93 yliJ; hypothetical GST-like protein YliJ K00799; COG: COG0625 GlutaTHIone S-transferase; Psort location: cytoplasmic, score: 23 YP_001588841.1 KEGG: sru:SRU_0451 1.1e-38 pyrroloquinoline-quinone glucose dehydrogenase; COG: COG2133 Glucose/sorbosone dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001588842.1 Psort location: nuclear, score: 23 YP_001588843.1 COG: COG2610 H+/gluconate symporter and related permeases; Psort location: endoplasmic reticulum, score: 9 YP_001588844.1 KEGG: shn:Shewana3_3435 6.3e-20 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001588845.1 KEGG: sec:SC0852 0. etfD; putative dehydrogenase (flavoproteins) K00311; COG: COG0644 Dehydrogenases (flavoproteins); Psort location: nuclear, score: 23 YP_001588846.1 Psort location: mitochondrial, score: 23 YP_001588847.1 KEGG: stm:STM0857 1.3e-211 putative acyl-CoA dehydrogenase K00249; COG: COG1960 Acyl-CoA dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001588848.1 COG: COG3777 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001588849.1 KEGG: fnu:FN1424 4.1e-21 acyl-CoA dehydrogenase, short-chain specific K00248; COG: COG2025 Electron transfer flavoprotein, alpha subunit; Psort location: cytoplasmic, score: 23 YP_001588850.1 COG: COG2086 Electron transfer flavoprotein, beta subunit; Psort location: cytoplasmic, score: 23 YP_001588851.1 KEGG: bmf:BAB2_0164 6.8e-20 citrate lyase, beta subunit, putative K01644; COG: COG2301 Citrate lyase beta subunit; Psort location: cytoplasmic, score: 23 YP_001588852.1 Psort location: cytoplasmic, score: 23 YP_001588853.1 COG: NOG04673 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001588854.1 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing YP_001588855.1 Psort location: nuclear, score: 23 YP_001588856.1 catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit YP_001588857.1 KEGG: rha:RHA1_ro09047 1.5e-06 ABC peptide transporter, permease component K02033; COG: COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001588858.1 KEGG: rha:RHA1_ro09047 3.4e-44 ABC peptide transporter, permease component K02033; COG: COG0601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001588859.1 KEGG: shn:Shewana3_2650 3.8e-36 acetate kinase K00925; COG: COG0747 ABC-type dipeptide transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001588860.1 with GsiBCD is involved in glutathione import; GsiA contains 2 ATP-binding domains YP_001588861.1 KEGG: stm:STM0847 7.8e-164 ybiK; putative asparaginase K01424; COG: COG1446 Asparaginase; Psort location: cytoplasmic, score: 23 YP_001588862.1 is involved in the formation of active molybdenum cofactor and the chelation of molybdenum YP_001588863.1 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase YP_001588864.1 Psort location: mitochondrial, score: 23 YP_001588865.1 KEGG: stm:STM0844 7.8e-164 pflE; putative pyruvate formate lyase activating enzyme K04069; COG: COG1180 Pyruvate-formate lyase-activating enzyme; Psort location: cytoplasmic, score: 23 YP_001588866.1 KEGG: sec:SC0838 0. pflF; putative pyruvate formate lyase K00656; COG: COG1882 Pyruvate-formate lyase; Psort location: cytoplasmic, score: 23 YP_001588867.1 KEGG: stm:STM0842 4.6e-143 ybiV(1); putative hydrolase of the HAD superfamily K07757; COG: COG0561 Predicted hydrolases of the HAD superfamily; Psort location: cytoplasmic, score: 23 YP_001588868.1 Psort location: cytoplasmic, score: 23 YP_001588869.1 COG: NOG06762 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001588870.1 KEGG: eci:UTI89_C0824 4.2e-275 ybiT; hypothetical ABC transporter ATP-binding protein YbiT K01957; COG: COG0488 ATPase components of ABC transporters with duplicated ATPase domains; Psort location: cytoplasmic, score: 23 YP_001588871.1 KEGG: eci:UTI89_C2228 1.5e-103 erfK; hypothetical protein K00257; COG: COG1376 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001588872.1 COG: COG0471 Di- and tricarboxylate transporters; Psort location: plasma membrane, score: 23 YP_001588873.1 Transcriptional regulator that represses the manganese transporter MntH when manganese is present YP_001588874.1 Psort location: cytoplasmic, score: 23 YP_001588875.1 Psort location: mitochondrial, score: 23 YP_001588876.1 KEGG: eci:UTI89_C0819 2.0e-243 ybiP; hypothetical protein YbiP K00924; COG: COG2194 Predicted membrane-associated, metal-dependent hydrolase; Psort location: endoplasmic reticulum, score: 9 YP_001588877.1 OmpX; involved in cell adhesion; forms an eight-stranded antiparallel beta-barrel that protrudes from the cell surface; mutations in the gene increase cell-surface contact in fimbriated strains but decrease contact in nonfimbriated strains YP_001588878.1 Psort location: nuclear, score: 23 YP_001588879.1 KEGG: pae:PA1977 6.5e-07 sensor protein GLPS; COG: COG5006 Predicted permease, DMT superfamily; Psort location: plasma membrane, score: 23 YP_001588880.1 Psort location: cytoplasmic, score: 23 YP_001588881.1 binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage YP_001588882.1 Psort location: cytoplasmic, score: 23 YP_001588883.1 similar to periplasmic-binding component of ABC transporters YP_001588884.1 similar to permease component of ABC transporters; mutations impair ability of Escherichia coli to transport and utilize glutamine YP_001588885.1 similar to ATP-binding component of ABC transporters YP_001588886.1 Psort location: nuclear, score: 23 YP_001588887.1 COG: COG0668 Small-conductance mechanosensitive channel; Psort location: plasma membrane, score: 23 YP_001588888.1 KEGG: vfi:VFA1153 4.0e-80 methyltransferase; COG: COG3129 Predicted SAM-dependent methyltransferase; Psort location: cytoplasmic, score: 23 YP_001588889.1 Psort location: nuclear, score: 23 YP_001588890.1 COG: COG1734 DnaK suppressor protein; Psort location: nuclear, score: 23 YP_001588891.1 Psort location: nuclear, score: 23 YP_001588892.1 COG: NOG33440 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001588893.1 COG: NOG13870 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001588894.1 KEGG: rso:RSc0378 2.6e-53 trpD3, RS03346; putative anthranilate phosphoribosyltransferase protein K00766; COG: COG0547 Anthranilate phosphoribosyltransferase; Psort location: cytoplasmic, score: 23 YP_001588895.1 helicase involved in DNA repair and perhaps also replication YP_001588896.1 Psort location: nuclear, score: 23 YP_001588897.1 this helicase is not essential cell growth YP_001588898.1 KEGG: stm:STM1749 0. adhE; alcohol dehydrogenase / acetaldehyde dehydrogenase K00001:K04072; COG: COG1012 NAD-dependent aldehyde dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001588899.1 KEGG: pol:Bpro_1462 2.0e-126 transketolase, central region K00615; COG: COG3958 Transketolase, C-terminal subunit; Psort location: cytoplasmic, score: 23 YP_001588900.1 KEGG: pol:Bpro_1461 2.5e-112 transketolase-like K00615; COG: COG3959 Transketolase, N-terminal subunit; Psort location: cytoplasmic, score: 23 YP_001588901.1 KEGG: pfo:Pfl_2721 4.3e-92 short-chain dehydrogenase/reductase SDR K00059; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001588902.1 KEGG: dre:30298 5.9e-05 jak2b; Janus kinase 2b K04447; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001588903.1 Psort location: nuclear, score: 23 YP_001588904.1 Psort location: nuclear, score: 23 YP_001588905.1 Psort location: cytoplasmic, score: 23 YP_001588906.1 KEGG: shn:Shewana3_3435 0.00044 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: mitochondrial, score: 23 YP_001588907.1 COG: COG1309 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001588908.1 COG: COG0845 Membrane-fusion protein; Psort location: endoplasmic reticulum, score: 9 YP_001588909.1 KEGG: rru:Rru_A1792 2.2e-166 ABC transporter component K01990; COG: COG1131 ABC-type multidrug transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001588910.1 KEGG: fal:FRAAL1796 1.9e-11 putative ABC transporter ATP-binding subunit; COG: COG0842 ABC-type multidrug transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001588911.1 KEGG: fal:FRAAL1796 1.1e-10 putative ABC transporter ATP-binding subunit; COG: COG0842 ABC-type multidrug transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001588912.1 COG: NOG09757 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 23 YP_001588913.1 Psort location: mitochondrial, score: 23 YP_001588914.1 KEGG: eci:UTI89_C0791 8.2e-121 ybhP; putative DNase; COG: COG3568 Metal-dependent hydrolase; Psort location: mitochondrial, score: 23 YP_001588915.1 KEGG: stt:t2076 4.9e-226 ybhO; putative phospholipase K06132; COG: COG1502 Phosphatidylserine/phosphatidylglycerophosphate/cardiolipi n synthases and related enzymes; Psort location: cytoplasmic, score: 23 YP_001588916.1 COG: COG0392 Predicted integral membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001588917.1 Psort location: endoplasmic reticulum, score: 9 YP_001588918.1 Psort location: endoplasmic reticulum, score: 9 YP_001588919.1 COG: COG0670 Integral membrane protein, interacts with FtsH; Psort location: endoplasmic reticulum, score: 9 YP_001588920.1 COG: COG0670 Integral membrane protein, interacts with FtsH; Psort location: endoplasmic reticulum, score: 9 YP_001588921.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin YP_001588922.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin YP_001588923.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis YP_001588924.1 KEGG: mtu:Rv0984 1.5e-11 moaB2; possible pterin-4-alpha-carbinolamine dehydratase MoaB2 (PHS) (4-alpha-hydroxy-tetrahydropterin dehydratase) (pterin-4-A-carbinolamine dehydratase) (phenylalanine hydroxylase-stimulating protein) (PHS) (pterin carbinolamine dehydratase) (PCD); COG: COG0521 Molybdopterin biosynthesis enzymes; Psort location: cytoplasmic, score: 23 YP_001588925.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z YP_001588926.1 KEGG: mth:MTH1018 5.6e-05 LPPG:FO 2-phopspho-L-lactate transferase K00924; COG: COG0391 Uncharacterized conserved protein; Psort location: extracellular, including cell wall, score: 9 YP_001588927.1 KEGG: rno:59265 1.5e-12 Phlpp; PH domain and leucine rich repeat protein phosphatase K01090; COG: COG4886 Leucine-rich repeat (LRR) protein; Psort location: nuclear, score: 23 YP_001588928.1 Psort location: nuclear, score: 23 YP_001588929.1 Psort location: nuclear, score: 23 YP_001588930.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_001588931.1 Psort location: cytoplasmic, score: 23 YP_001588932.1 Psort location: cytoplasmic, score: 23 YP_001588933.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium YP_001588934.1 putative methyltransferase; acyl carrier protein involved in an unidentified step in the synthesis of pimeloyl-CoA, a biotin precursor; member of the bio operon (bioABFCD); in Escherichia coli, bioC-null mutants require biotin for growth YP_001588935.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine YP_001588936.1 KEGG: stm:STM0794 9.1e-186 bioB; biotin synthetase K01012; COG: COG0502 Biotin synthase and related enzymes; Psort location: nuclear, score: 23 YP_001588937.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate YP_001588938.1 YbhB; similar to rat and human kinase inhibitory proteins YP_001588939.1 catalyzes the degradation of histidine to urocanate and ammmonia YP_001588940.1 catalyzes the formation of 4-imidazolone-5-propanoate from urocanate during histidine metabolism YP_001588941.1 KEGG: reh:H16_A3019 5.9e-56 hutC; histidine utilization repressor; COG: COG2188 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001588942.1 catalyzes the formation of glutamate and formamide from N-formimidoyl-L-glutamate YP_001588943.1 catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway YP_001588944.1 outer membrane lipoprotein that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; YbhC localizes to the cellular poles; member of pectinesterase family YP_001588945.1 Psort location: extracellular, including cell wall, score: 9 YP_001588946.1 catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate YP_001588947.1 YbhA; catalyzes the dephosphorylation of pyridoxal phosphate, fructose 1,6-bisphosphate, erythrose 4-phosphate and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; phosphotransferase activity observed when using monophosphates as phosphate donor; member of the haloacid dehalogenase-like hydrolases superfamily YP_001588948.1 Part of the ABC transporter complex modABC involved in molybdenum import YP_001588949.1 part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE YP_001588950.1 with ModCB is involved in the high-affinity transport of molybdate YP_001588951.1 COG: NOG17580 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001588952.1 represses the modABCD operon and activates the moaABCD and napFDAGHBC operons YP_001588953.1 contains 2 ATP-binding cassettes; involved in the transport of molybdenum YP_001588954.1 Psort location: cytoplasmic, score: 23 YP_001588955.1 COG: COG4714 Uncharacterized membrane-anchored protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001588956.1 KEGG: stm:STM0776 6.4e-185 galE; UDP-galactose 4-epimerase K01784; COG: COG1087 UDP-glucose 4-epimerase; Psort location: cytoplasmic, score: 23 YP_001588957.1 catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P YP_001588958.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism YP_001588959.1 catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose YP_001588960.1 Psort location: nuclear, score: 23 YP_001588961.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate YP_001588962.1 KEGG: stm:STM0771 1.7e-129 putative ABC-type cobalamin/Fe3+-siderophores transport system, ATPase component K02013; COG: COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components; Psort location: extracellular, including cell wall, score: 9 YP_001588963.1 COG: COG0609 ABC-type Fe3+-siderophore transport system, permease component; Psort location: plasma membrane, score: 23 YP_001588964.1 KEGG: sec:SC0057 9.9e-22 citG2; putative modifier of citrate lyase protein K05966; COG: COG1767 Triphosphoribosyl-dephospho-CoA synthetase; Psort location: cytoplasmic, score: 23 YP_001588965.1 catalyzes the formation of pyruvate from oxaloacetate YP_001588966.1 catalyzes the decarboxylation of oxaloacetate to form pyruvate and carbon dioxide YP_001588967.1 KEGG: ecj:JW3469 1.5e-08 arsB; arsenite/antimonite transporter K03893; COG: COG0471 Di- and tricarboxylate transporters; Psort location: plasma membrane, score: 23 YP_001588968.1 KEGG: shn:Shewana3_3435 9.4e-10 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001588969.1 KEGG: shn:Shewana3_3435 1.2e-27 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: mitochondrial, score: 23 YP_001588970.1 Psort location: mitochondrial, score: 23 YP_001588971.1 Catalyzes the reversible hydration of fumaric acid to yield I-malic acid YP_001588972.1 KEGG: stm:STM0761 1.8e-93 fumarate hydratase Class I anaerobic K01678; COG: COG1838 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain; Psort location: cytoplasmic, score: 23 YP_001588973.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive YP_001588974.1 Psort location: nuclear, score: 23 YP_001588975.1 KEGG: cal:orf19.4072 0.00075 HYR10; similar to cell surface flocculin K01186; COG: NOG09755 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001588976.1 involved in zinc efflux across the cytoplasmic membrane YP_001588977.1 COG: COG3201 Nicotinamide mononucleotide transporter; Psort location: plasma membrane, score: 23 YP_001588978.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate YP_001588979.1 Psort location: nuclear, score: 23 YP_001588981.1 periplasmic protein that interacts with TolA; the tol-pal system is probably involved in maintaining cell envelope integrity YP_001588982.1 KEGG: bxe:Bxe_A4171 1.5e-07 putative cytochrome c oxidase K00403; COG: COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins; Psort location: nuclear, score: 23 YP_001588983.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA YP_001588984.1 inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins YP_001588985.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins YP_001588986.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins YP_001588987.1 catalyzes the hydrolysis of short chain aliphatic acyl-CoA thioesters; physiological role remains unknown; involved in phospholipid metabolism; part of the Tol/Pal system of proteins that are critical for maintaining the integrity of the cell envelope components YP_001588988.1 COG: COG3790 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001588989.1 Psort location: mitochondrial, score: 23 YP_001588990.1 COG: COG4890 Predicted outer membrane lipoprotein; Psort location: extracellular, including cell wall, score: 9 YP_001588991.1 KEGG: spt:SPA2002 1.2e-206 cydB; cytochrome d ubiquinol oxidase subunit II K00426; COG: COG1294 Cytochrome bd-type quinol oxidase, subunit 2; Psort location: plasma membrane, score: 23 YP_001588992.1 KEGG: stm:STM0740 3.1e-279 cydA; cytochrome d terminal oxidase, polypeptide subunit I K00425; COG: COG1271 Cytochrome bd-type quinol oxidase, subunit 1; Psort location: plasma membrane, score: 23 YP_001588993.1 Psort location: nuclear, score: 23 YP_001588994.1 Psort location: cytoplasmic, score: 23 YP_001588995.1 Psort location: cytoplasmic, score: 23 YP_001588996.1 Psort location: cytoplasmic, score: 23 YP_001588997.1 Psort location: nuclear, score: 23 YP_001588998.1 Psort location: cytoplasmic, score: 23 YP_001588999.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle YP_001589000.1 catalyzes the interconversion of succinyl-CoA and succinate YP_001589001.1 Psort location: cytoplasmic, score: 23 YP_001589002.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA YP_001589003.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide YP_001589004.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase YP_001589005.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol YP_001589006.1 KEGG: sty:STY0776 3.6e-56 sdhD; succinate dehydrogenase hydrophobic membrane anchor protein K00242; COG: COG2142 Succinate dehydrogenase, hydrophobic anchor subunit; Psort location: endoplasmic reticulum, score: 9 YP_001589007.1 KEGG: spt:SPA2011 4.7e-63 sdhC; succinate dehydrogenase cytochrome b-556 subunit K00241; COG: COG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit; Psort location: endoplasmic reticulum, score: 9 YP_001589008.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH YP_001589009.1 COG: COG3180 Putative ammonia monooxygenase; Psort location: plasma membrane, score: 23 YP_001589010.1 5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity YP_001589011.1 COG: NOG33349 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589012.1 COG: COG5610 Predicted hydrolase (HAD superfamily); Psort location: cytoplasmic, score: 23 YP_001589013.1 COG: COG0463 Glycosyltransferases involved in cell wall biogenesis; Psort location: cytoplasmic, score: 23 YP_001589014.1 KEGG: mbo:Mb3838c 1.8e-22 galactofuranosyl transferase; COG: COG1216 Predicted glycosyltransferases; Psort location: endoplasmic reticulum, score: 9 YP_001589015.1 KEGG: lpn:lpg0773 1.8e-38 polysaccharide ABC transporter, ATP binding protein K01990; COG: COG1134 ABC-type polysaccharide/polyol phosphate transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001589016.1 COG: COG1682 ABC-type polysaccharide/polyol phosphate export systems, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001589017.1 KEGG: sat:SYN_02667 3.5e-49 alpha-D-QuiNAc alpha-1,3-galactosyltransferase K00754; COG: COG0438 Glycosyltransferase; Psort location: cytoplasmic, score: 23 YP_001589018.1 KEGG: tth:TTC0528 8.8e-15 rfbF; dTDP-rhamnosyl transferase RfbF; COG: COG1216 Predicted glycosyltransferases; Psort location: cytoplasmic, score: 23 YP_001589019.1 KEGG: spt:SPA2022 7.3e-184 UDP-galactopyranose mutase K01854; COG: COG0562 UDP-galactopyranose mutase; Psort location: cytoplasmic, score: 23 YP_001589020.1 Psort location: cytoplasmic, score: 23 YP_001589021.1 COG: NOG25230 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001589022.1 COG: NOG29749 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001589023.1 COG: COG0582 Integrase; Psort location: mitochondrial, score: 23 YP_001589024.1 COG: NOG34016 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589025.1 COG: COG1540 Uncharacterized proteins, homologs of lactam utilization protein B; Psort location: cytoplasmic, score: 23 YP_001589026.1 KEGG: eci:UTI89_C0710 3.2e-142 ybgK; hypothetical protein K01941; COG: COG1984 Allophanate hydrolase subunit 2; Psort location: cytoplasmic, score: 23 YP_001589027.1 KEGG: eci:UTI89_C0709 3.7e-102 ybgJ; hypothetical protein YbgJ K01457; COG: COG2049 Allophanate hydrolase subunit 1; Psort location: cytoplasmic, score: 23 YP_001589028.1 COG: COG0327 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001589029.1 Psort location: nuclear, score: 23 YP_001589030.1 KEGG: ace:Acel_1973 0.0016 V-type H(+)-translocating pyrophosphatase K01507; COG: COG3104 Dipeptide/tripeptide permease; Psort location: plasma membrane, score: 23 YP_001589031.1 UV-induced DNA repair; converts cyclobutane-type pyrimidine dimers created during exposure to UV ratiation to monomers; light dependent YP_001589032.1 COG: COG1943 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001589033.1 Psort location: cytoplasmic, score: 23 YP_001589034.1 COG: NOG13868 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589035.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions YP_001589036.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions YP_001589037.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex YP_001589038.1 sensory histidine kinase in two-component regulatory system with KdpE; signal sensing protein YP_001589039.1 response regulator in two-component regulatory system with KdpD; regulates the kdp operon involved in potassium transport YP_001589040.1 Psort location: cytoplasmic, score: 23 YP_001589041.1 Psort location: cytoplasmic, score: 23 YP_001589042.1 KEGG: stm:STM0701 0. speF; orniTHIne decarboxylase isozyme K01581; COG: COG1982 Arginine/lysine/orniTHIne decarboxylases; Psort location: cytoplasmic, score: 23 YP_001589043.1 catalyzes the uptake of putrescine via a proton symport mechanism, as well as the efflux of putrescine by a putrescine/ornithine antiport system YP_001589044.1 COG: COG3467 Predicted flavin-nucleotide-binding protein; Psort location: cytoplasmic, score: 23 YP_001589045.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate YP_001589046.1 negative modulator of the initiation of chromosome replication YP_001589047.1 KEGG: spt:SPA2045 1.2e-137 ybfF; putative esterase/lipase YbfF; COG: COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily); Psort location: cytoplasmic, score: 23 YP_001589048.1 Psort location: nuclear, score: 23 YP_001589049.1 COG: NOG13544 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001589050.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_001589051.1 Psort location: cytoplasmic, score: 23 YP_001589052.1 negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer YP_001589053.1 KEGG: shn:Shewana3_3435 3.2e-05 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001589054.1 catalyzes the oxidation of tricarballylate to cis-aconitate; FAD-dependent; required for the utilization of tricarballylate as a carbon and energy source by S. enterica YP_001589055.1 KEGG: afu:AF0661 5.3e-10 heterodisulfide reductase, subunit E, putative K03390; COG: NOG06514 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 23 YP_001589056.1 KEGG: cal:orf19.4384 1.4e-05 HXT10; fructose symporter K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001589057.1 COG: NOG11319 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001589058.1 KEGG: psp:PSPPH_3782 2.5e-12 porin D; COG: NOG06287 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001589059.1 Psort location: nuclear, score: 23 YP_001589060.1 Psort location: cytoplasmic, score: 23 YP_001589061.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001589062.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_001589063.1 Psort location: nuclear, score: 23 YP_001589064.1 catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate YP_001589065.1 catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate YP_001589066.1 KEGG: eci:UTI89_C0670 8.1e-201 nagC; transcriptional repressor of nag (N-acetylglucosamine) operon K02565; COG: COG1940 Transcriptional regulator/sugar kinase; Psort location: cytoplasmic, score: 23 YP_001589067.1 KEGG: eci:UTI89_C0669 1.3e-129 nagD; N-acetylglucosamine metabolism K02566; COG: COG0647 Predicted sugar phosphatases of the HAD superfamily; Psort location: cytoplasmic, score: 23 YP_001589068.1 functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP YP_001589072.1 Psort location: endoplasmic reticulum, score: 9 YP_001589073.1 catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q YP_001589074.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_001589075.1 Psort location: mitochondrial, score: 23 YP_001589076.1 Psort location: cytoplasmic, score: 23 YP_001589077.1 KEGG: reh:H16_A0527 4.2e-85 phoH; phosphate starvation-inducible protein PhoH,predicted ATPase; COG: COG1702 Phosphate starvation-inducible protein PhoH, predicted ATPase; Psort location: cytoplasmic, score: 23 YP_001589078.1 KEGG: dps:DP1605 2.1e-09 probable pyridoxal phosphate biosynthetic protein K03474; COG: COG0319 Predicted metal-dependent hydrolase; Psort location: cytoplasmic, score: 23 YP_001589079.1 Psort location: nuclear, score: 23 YP_001589080.1 KEGG: eci:UTI89_C0656 1.6e-149 ybeX; putative transport protein K06189; COG: COG4535 Putative Mg2+ and Co2+ transporter CorC; Psort location: cytoplasmic, score: 23 YP_001589081.1 Transfers the fatty acyl group on membrane lipoproteins YP_001589082.1 KEGG: bur:Bcep18194_A4762 9.9e-22 ABC amino acid transporter, periplasmic ligand binding protein K01713; COG: COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; Psort location: extracellular, including cell wall, score: 9 YP_001589083.1 KEGG: eca:ECA0855 4.9e-20 ABC transporter permease protein K02028; COG: COG0765 ABC-type amino acid transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001589084.1 KEGG: ret:RHE_PF00254 2.0e-26 glnP, glnQ; glutamine ABC transporter, ATP-binding protein K02028; COG: COG0765 ABC-type amino acid transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001589085.1 KEGG: stt:t2211 5.4e-124 gltL; glutamate/aspartate transport ATP-binding protein GltL K02028; COG: COG1126 ABC-type polar amino acid transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001589086.1 Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively; pyrimidine-specific YP_001589087.1 Psort location: cytoplasmic, score: 23 YP_001589088.1 KEGG: mbo:Mb0358 1.5e-80 dnaK; probable chaperone protein DnaK (heat shock protein 70) (heat shock 70 kda protein) (HSP70) K04043; COG: COG0443 Molecular chaperone; Psort location: cytoplasmic, score: 23 YP_001589089.1 COG: NOG07566 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589090.1 COG: NOG09046 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589091.1 COG: NOG06784 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589092.1 Psort location: mitochondrial, score: 23 YP_001589093.1 KEGG: cch:Cag_1938 1.7e-51 Sel1-like repeat; COG: COG0790 FOG: TPR repeat, SEL1 subfamily; Psort location: cytoskeletal, score: 9 YP_001589094.1 COG: NOG08739 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589095.1 KEGG: reh:H16_A1904 1.2e-71 prpR; propionate catabolism activator K01529; COG: COG3829 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains; Psort location: extracellular, including cell wall, score: 9 YP_001589096.1 transports degraded pectin products into the bacterial cell YP_001589097.1 KEGG: stm:STM0650 2.4e-208 putative hydrolase C-terminus K01685; COG: COG2721 Altronate dehydratase; Psort location: cytoplasmic, score: 23 YP_001589098.1 KEGG: stt:t2218 4.5e-49 putative hydrolase N-terminus K01685; COG: COG2721 Altronate dehydratase; Psort location: cytoplasmic, score: 23 YP_001589099.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_001589100.1 rare lipoprotein B; involved in the assembly of LPS in the outer membrane YP_001589101.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA YP_001589102.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria YP_001589103.1 cobalamin biosynthesis protein; decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin; structurally similar to histidinol phosphate aminotransferase YP_001589104.1 KEGG: stm:STM0643 2.6e-108 cobC; alpha ribazole-5'-P phosphatase in cobalamin synthesis K02226; COG: COG0406 Fructose-2,6-bisphosphatase; Psort location: endoplasmic reticulum, score: 9 YP_001589105.1 Psort location: cytoplasmic, score: 23 YP_001589106.1 Psort location: cytoplasmic, score: 23 YP_001589107.1 KEGG: bba:Bd3846 5.6e-10 probable nicotinate-nucleotide adenylyltransferase K00969; COG: COG0799 Uncharacterized homolog of plant Iojap protein; Psort location: cytoplasmic, score: 23 YP_001589108.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA YP_001589109.1 KEGG: eci:UTI89_C0637 0. mrdA; cell elongation, e phase; peptidoglycan synthetase; penicillin-binding protein 2 K05515; COG: COG0768 Cell division protein FtsI/penicillin-binding protein 2; Psort location: cytoplasmic, score: 23 YP_001589110.1 COG: COG0772 Bacterial cell division membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001589111.1 KEGG: pfo:Pfl_1900 2.2e-08 argininosuccinate synthase K03749; COG: COG0797 Lipoproteins; Psort location: nuclear, score: 23 YP_001589112.1 penicillin-binding protein 5; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors YP_001589113.1 KEGG: dme:Dmel_CG10495 0.0086 CG10495 K05545; COG: COG2921 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001589114.1 Psort location: cytoplasmic, score: 23 YP_001589115.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein YP_001589116.1 Psort location: mitochondrial, score: 23 YP_001589117.1 COG: COG0583 Transcriptional regulator; Psort location: nuclear, score: 23 YP_001589118.1 Psort location: cytoplasmic, score: 23 YP_001589119.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_001589120.1 TatE; similar to TatA and found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes YP_001589121.1 KEGG: eci:UTI89_C0629 1.3e-99 ybeM; putative amidase K01501; COG: COG0388 Predicted amidohydrolase; Psort location: cytoplasmic, score: 23 YP_001589122.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling YP_001589123.1 COG: COG1943 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001589124.1 Psort location: cytoplasmic, score: 23 YP_001589125.1 member of the CspA family; constitutively expressed RNA/ssDNA-binding protein; functions in helping cells adapt to low temperature; aids nucleic acid melting; participates in gene regulation; can act as a transcription antiterminator YP_001589126.1 catalyzes the transfer of palmitate to lipid A YP_001589127.1 Psort location: cytoplasmic, score: 23 YP_001589128.1 responsible for the transport of C4-dicarboxylates during anaerobic growth YP_001589129.1 regulates the expression of citAB in citrate fermentation YP_001589130.1 KEGG: stt:t2242 3.8e-290 dpiB; sensor kinase DpiB K07700; COG: COG3290 Signal transduction histidine kinase regulating citrate/malate metabolism; Psort location: endoplasmic reticulum, score: 9 YP_001589131.1 Psort location: nuclear, score: 23 YP_001589132.1 Psort location: cytoplasmic, score: 23 YP_001589133.1 KEGG: stm:STM0624 5.1e-192 citC; citrate lyase synthetase K01910; COG: COG3053 Citrate lyase synthetase; Psort location: cytoplasmic, score: 23 YP_001589134.1 acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate YP_001589135.1 KEGG: stm:STM0622 3.5e-152 citE; citrate lyase beta chain (acyl lyase subunit) K01660:K01644; COG: COG2301 Citrate lyase beta subunit; Psort location: mitochondrial, score: 23 YP_001589136.1 KEGG: stm:STM0621 1.4e-267 citF; bifunctional citrate lyase alpha chain/citrate-ACP transferase K01037:K01643; COG: COG3051 Citrate lyase, alpha subunit; Psort location: cytoplasmic, score: 23 YP_001589137.1 2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase; holo-citrate lyase synthase; CitG forms the prosthetic group precursor 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA which is then transferred to apo-ACP by CitX to produce holo-ACP and pyrophosphate YP_001589138.1 catalyzes the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA from ATP and 3-dephospho-CoA YP_001589139.1 COG: COG0471 Di- and tricarboxylate transporters; Psort location: plasma membrane, score: 23 YP_001589140.1 KEGG: stt:t2250 5.0e-146 rna; ribonuclease I precursor K01169; COG: COG3719 Ribonuclease I; Psort location: extracellular, including cell wall, score: 9 YP_001589141.1 Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation YP_001589142.1 KEGG: psp:PSPPH_3469 1.3e-161 fdh; glutaTHIone-dependent formaldehyde dehydrogenase; COG: COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases; Psort location: endoplasmic reticulum, score: 9 YP_001589143.1 Psort location: cytoplasmic, score: 23 YP_001589144.1 Psort location: nuclear, score: 23 YP_001589145.1 COG: COG0589 Universal stress protein UspA and related nucleotide-binding proteins; Psort location: cytoplasmic, score: 23 YP_001589146.1 KEGG: dsy:DSY0599 1.3e-17 dmsC; putative anaerobic DMSO reductase chain C anchor subunit K00369; COG: COG3302 DMSO reductase anchor subunit; Psort location: plasma membrane, score: 23 YP_001589147.1 KEGG: dsy:DSY0598 2.0e-46 dmsB; putative anaerobic DMSO reductase chain B iron-sulfur subunit K00369; COG: COG0437 Fe-S-cluster-containing hydrogenase components 1; Psort location: nuclear, score: 23 YP_001589148.1 KEGG: dsy:DSY0597 4.6e-198 dmsA; putative anaerobic DMSO reductase chain A precursor K00369; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: cytoplasmic, score: 23 YP_001589149.1 KEGG: vfi:VFA0083 2.7e-12 ynfI; anaerobic dimethyl sulfoxide reductase chain YnfI K00397; COG: COG3381 Uncharacterized component of anaerobic dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001589150.1 KEGG: stm:STM0609 3.3e-275 ahpF; alkyl hydroperoxide reductase, F52a subunit; detoxification of hydroperoxides K03387; COG: COG3634 Alkyl hydroperoxide reductase, large subunit; Psort location: cytoplasmic, score: 23 YP_001589151.1 with AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols; AhpC reduced the hydroperoxide substrate YP_001589152.1 Involved in disulfide bond formation YP_001589153.1 COG: COG0583 Transcriptional regulator; Psort location: nuclear, score: 23 YP_001589154.1 KEGG: eci:UTI89_C2238 3.4e-131 ibrA; hypothetical protein YbdN K00390; COG: COG3969 Predicted phosphoadenosine phosphosulfate sulfotransferase; Psort location: cytoplasmic, score: 23 YP_001589155.1 COG: COG1475 Predicted transcriptional regulators; Psort location: cytoskeletal, score: 9 YP_001589156.1 catalyzes the transfer of an amino moiety YP_001589157.1 member of the iron-containing alcohol dehydrogenase family; unknown function YP_001589158.1 COG: COG2879 Uncharacterized small protein; Psort location: cytoplasmic, score: 23 YP_001589159.1 KEGG: xtr:3283503 0.0032 ND6; NADH dehydrogenase subunit 6 K03884; COG: COG1966 Carbon starvation protein, predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001589160.1 Psort location: nuclear, score: 23 YP_001589161.1 KEGG: eco:b0597 1.6e-67 ybdB; hypothetical protein; COG: COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism; Psort location: cytoplasmic, score: 23 YP_001589162.1 catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin YP_001589163.1 KEGG: spt:SPA2137 2.4e-153 entB; isochorismatase K01252; COG: COG3433 Aryl carrier domain; Psort location: cytoplasmic, score: 23 YP_001589164.1 bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate YP_001589165.1 KEGG: stm:STM0595 3.6e-207 entC; isochorismate synthetase, enterochelin biosynthesis K02361; COG: COG1169 Isochorismate synthase; Psort location: cytoplasmic, score: 23 YP_001589166.1 with FepCDG is involved in the transport of ferric enterobactin YP_001589167.1 protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters YP_001589168.1 with FepBCG is involved in the transport of ferric enterobactin YP_001589169.1 with FepBCD is involved in the transport of ferric enterobactin YP_001589170.1 with FepBDE is involved in the transport of ferric enterobactin YP_001589171.1 part of the ferric enterobactin transport system; necessary for enetrobactin uptake YP_001589172.1 with EntB, EntD, and EntE forms the multienzyme complex enterobactin synthase; EntF is the serine activating enzyme which catalyzes the formation of the amide and ester bonds of the cyclic enterobactin YP_001589173.1 COG: COG3251 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001589174.1 KEGG: btk:BT9727_2470 3.1e-12 probable esterase K07214; COG: COG2382 Enterochelin esterase and related enzymes; Psort location: cytoplasmic, score: 23 YP_001589175.1 Psort location: extracellular, including cell wall, score: 9 YP_001589176.1 Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space YP_001589177.1 KEGG: stt:t2284 4.7e-118 entD; enterobactin synthetase component D K02362; COG: COG2977 Phosphopantetheinyl transferase component of siderophore synthetase; Psort location: cytoplasmic, score: 23 YP_001589178.1 ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity YP_001589179.1 COG: NOG15356 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001589180.1 KEGG: bcz:BCZK3497 1.1e-08 adaA; transcriptional regulator, AraC family K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001589181.1 COG: COG1309 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001589182.1 COG: COG2315 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001589183.1 catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive YP_001589184.1 Psort location: nuclear, score: 23 YP_001589185.1 KEGG: pen:PSEEN0445 3.7e-22 estA; esterase EstA precursor K01044; COG: COG3240 Phospholipase/leciTHInase/hemolysin; Psort location: endoplasmic reticulum, score: 9 YP_001589186.1 Psort location: nuclear, score: 23 YP_001589187.1 COG: COG0668 Small-conductance mechanosensitive channel; Psort location: plasma membrane, score: 23 YP_001589188.1 KEGG: eci:UTI89_C0120 9.8e-157 aroP; aromatic amino acid transport protein AroP K03293; COG: COG1113 Gamma-aminobutyrate permease and related permeases; Psort location: plasma membrane, score: 23 YP_001589189.1 KEGG: ptr:452298 2.0e-05 LOC452298; similar to rho/rac-interacting citron kinase K08282; COG: COG1076 DnaJ-domain-containing proteins 1; Psort location: nuclear, score: 23 YP_001589190.1 COG: COG3059 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001589191.1 COG: NOG18530 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001589192.1 Psort location: cytoplasmic, score: 23 YP_001589193.1 Involved in disulfide oxidoreductase activity and electron transport YP_001589194.1 KEGG: bur:Bcep18194_C7173 4.7e-07 two component transcriptional regulator, AraC family; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001589195.1 COG: COG3696 Putative silver efflux pump; Psort location: mitochondrial, score: 23 YP_001589196.1 KEGG: sec:SC0599 6.5e-25 cusS; sensor protein K07644; COG: COG0642 Signal transduction histidine kinase; Psort location: cytoplasmic, score: 23 YP_001589197.1 Psort location: nuclear, score: 23 YP_001589198.1 Psort location: cytoplasmic, score: 23 YP_001589199.1 COG: COG2246 Predicted membrane protein; Psort location: cytoplasmic, score: 23 YP_001589200.1 KEGG: stm:STM0558 9.8e-157 yfdH; putative glycosyltransferase K00754; COG: COG0463 Glycosyltransferases involved in cell wall biogenesis; Psort location: cytoplasmic, score: 23 YP_001589201.1 COG: NOG14427 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001589202.1 Psort location: cytoplasmic, score: 23 YP_001589203.1 COG: COG2963 Transposase and inactivated derivatives; Psort location: nuclear, score: 23 YP_001589204.1 COG: COG0582 Integrase; Psort location: mitochondrial, score: 23 YP_001589205.1 Psort location: nuclear, score: 23 YP_001589206.1 COG: COG2771 DNA-binding HTH domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001589207.1 COG: NOG29740 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589208.1 COG: NOG24886 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001589209.1 Psort location: cytoplasmic, score: 23 YP_001589210.1 activates the production of the major fimbrae protein FimA YP_001589211.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001589212.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001589213.1 COG: COG3188 P pilus assembly protein, porin PapC; Psort location: extracellular, including cell wall, score: 9 YP_001589214.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: extracellular, including cell wall, score: 9 YP_001589215.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001589216.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: endoplasmic reticulum, score: 9 YP_001589217.1 Psort location: cytoplasmic, score: 23 YP_001589218.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate YP_001589219.1 COG: COG2501 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001589220.1 COG: COG1988 Predicted membrane-bound metal-dependent hydrolases; Psort location: endoplasmic reticulum, score: 9 YP_001589221.1 Psort location: endoplasmic reticulum, score: 9 YP_001589222.1 COG: COG4727 Uncharacterized protein conserved in bacteria; Psort location: mitochondrial, score: 23 YP_001589223.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_001589224.1 KEGG: sty:STY0584 8.5e-87 ppiB; peptidyl-prolyl cis-trans isomerase B K03768; COG: COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family; Psort location: cytoplasmic, score: 23 YP_001589225.1 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine YP_001589226.1 KEGG: stm:STM0534 4.2e-85 purE; phosphoribosylaminoimidazole carboxylase = AIR carboxylase, catalytic subunit K01588; COG: COG0041 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase; Psort location: cytoplasmic, score: 23 YP_001589227.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway YP_001589228.1 KEGG: stm:STM0532 2.7e-154 arcC; carbamate kinase K00926; COG: COG0549 Carbamate kinase; Psort location: cytoplasmic, score: 23 YP_001589229.1 COG: NOG06194 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589230.1 COG: NOG06566 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589231.1 multicopy suppressor of dominant negative ftsH mutations YP_001589232.1 KEGG: spt:SPA2195 9.1e-186 allD; ureidoglycolate dehydrogenase K00073; COG: COG2055 Malate/L-lactate dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001589233.1 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide YP_001589234.1 COG: COG3257 Uncharacterized protein, possibly involved in glyoxylate utilization; Psort location: cytoplasmic, score: 23 YP_001589235.1 KEGG: stm:STM0525 3.5e-200 glxK; glycerate kinase II K00865; COG: COG1929 Glycerate kinase; Psort location: cytoplasmic, score: 23 YP_001589236.1 COG: COG2233 XanTHIne/uracil permeases; Psort location: plasma membrane, score: 23 YP_001589237.1 Plays a crucial role on both purine and pyrimidine metabolism YP_001589238.1 KEGG: pca:Pcar_0215 0.0048 NADH dehydrogenase I, M subunit K00342; COG: COG1953 Cytosine/uracil/THIamine/allantoin permeases; Psort location: plasma membrane, score: 23 YP_001589239.1 KEGG: azo:azo0148 0.00043 putative acyltransferase family protein K00680; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001589240.1 KEGG: stm:STM0519 2.9e-150 glxR; tartronic semialdehyde reductase K00042; COG: COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases; Psort location: endoplasmic reticulum, score: 9 YP_001589241.1 KEGG: spt:SPA2204 3.0e-139 hyi; hydroxypyruvate isomerase K01816; COG: COG3622 Hydroxypyruvate isomerase; Psort location: cytoplasmic, score: 23 YP_001589242.1 catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate YP_001589243.1 Psort location: extracellular, including cell wall, score: 9 YP_001589244.1 regulates operons involved in the utilization of allantoin YP_001589245.1 catalyzes the formation of glyoxylate from (S)-ureidoglycolate YP_001589246.1 activator of the allDC-ylbA operon involved in allantoin utilization YP_001589247.1 catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA YP_001589248.1 KEGG: baa:BA_0884 7.6e-47 binding-protein-dependent transport systems inner membrane component K00294; COG: COG2011 ABC-type metal ion transport system, permease component; Psort location: plasma membrane, score: 23 YP_001589249.1 KEGG: rru:Rru_A0788 1.7e-79 ABC transporter component K06020; COG: COG1135 ABC-type metal ion transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001589250.1 COG: COG1464 ABC-type metal ion transport system, periplasmic component/surface antigen; Psort location: extracellular, including cell wall, score: 9 YP_001589251.1 Psort location: nuclear, score: 23 YP_001589252.1 COG: COG3203 Outer membrane protein (porin); Psort location: endoplasmic reticulum, score: 9 YP_001589253.1 Psort location: cytoplasmic, score: 23 YP_001589254.1 COG: COG3127 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001589255.1 KEGG: pen:PSEEN1885 7.8e-61 ABC transporter, ATP-binding protein; COG: COG4181 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component; Psort location: cytoplasmic, score: 23 YP_001589256.1 KEGG: sty:STY0552 1.3e-108 tesA; acyl-coA THIoesterase I K01076; COG: COG2755 Lysophospholipase L1 and related esterases; Psort location: extracellular, including cell wall, score: 9 YP_001589257.1 KEGG: sty:STY0551 2.3e-132 ybbO; hypothetical oxidoreductase; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001589258.1 KEGG: eci:UTI89_C0527 3.7e-141 ybbN; putative THIoredoxin-like protein K05838; COG: COG3118 Thioredoxin domain-containing protein; Psort location: cytoplasmic, score: 23 YP_001589259.1 COG: COG0390 ABC-type uncharacterized transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001589260.1 KEGG: rru:Rru_A0497 7.9e-29 ABC transporter component K06020; COG: COG4619 ABC-type uncharacterized transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001589261.1 KEGG: reh:H16_A2036 5.7e-58 membrane protease subunits, stomatin/prohibitin homologs K01423; COG: COG0330 Membrane protease subunits, stomatin/prohibitin homologs; Psort location: endoplasmic reticulum, score: 9 YP_001589262.1 COG: COG1585 Membrane protein implicated in regulation of membrane protease activity; Psort location: endoplasmic reticulum, score: 9 YP_001589263.1 activator of copper-responsive regulon genes YP_001589264.1 KEGG: sty:STY0544 0. ybaR; copper-transporting ATPase K01533; COG: COG2217 Cation transport ATPase; Psort location: endoplasmic reticulum, score: 9 YP_001589265.1 COG: NOG23012 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001589266.1 COG: COG3735 Uncharacterized protein conserved in bacteria; Psort location: mitochondrial, score: 23 YP_001589267.1 KEGG: gme:Gmet_1354 0.0027 prolyl-tRNA synthetase K01881; COG: COG2606 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001589268.1 catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides YP_001589269.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001589270.1 Psort location: mitochondrial, score: 23 YP_001589271.1 YbaL; member of the CPA-2 family of antiporters; uncharacterized protein YP_001589272.1 KEGG: sec:SC0533 3.7e-244 gsk; inosine-guanosine kinase K00892; COG: COG0524 Sugar kinases, ribokinase family; Psort location: mitochondrial, score: 23 YP_001589273.1 KEGG: stm:STM0490 3.0e-178 aes; acetyl esterase K01066; COG: COG0657 Esterase/lipase; Psort location: cytoplasmic, score: 23 YP_001589274.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic YP_001589275.1 Psort location: nuclear, score: 23 YP_001589276.1 KEGG: sty:STY0532 3.4e-99 adk; adenylate kinase K00939; COG: COG0563 Adenylate kinase and related kinases; Psort location: cytoplasmic, score: 23 YP_001589277.1 Psort location: nuclear, score: 23 YP_001589278.1 Psort location: cytoplasmic, score: 23 YP_001589279.1 Psort location: cytoplasmic, score: 23 YP_001589280.1 molecular chaperone YP_001589281.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_001589282.1 COG: COG0718 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001589283.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA YP_001589284.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis YP_001589285.1 Psort location: nuclear, score: 23 YP_001589286.1 COG: COG2832 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001589287.1 PriC; protein involved in DNA replication; part of the primosome, a protein complex required to restart stalled replication forks; binds the complex formed by PriA, PriB and DNA; PriC-dependent primosome requires a gap to restart DNA replication; stimulates Rep activity at stalled forks YP_001589288.1 COG: NOG18531 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589289.1 COG: COG5464 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001589290.1 small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS YP_001589291.1 Psort location: nuclear, score: 23 YP_001589292.1 regulates the acrAB operon which is involved in susceptibility to dephalothin and cephaloridine YP_001589293.1 KEGG: saz:Sama_0326 0.0022 phosphopantothenoylcysteine decarboxylase, phosphopantothenate--cysteine ligase K01598:K01922; COG: COG0845 Membrane-fusion protein; Psort location: extracellular, including cell wall, score: 9 YP_001589294.1 KEGG: eci:UTI89_C2351 5.5e-108 yegO; hypothetical protein YegO K07789; COG: COG0841 Cation/multidrug efflux pump; Psort location: plasma membrane, score: 23 YP_001589295.1 COG: NOG09846 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001589296.1 with Hns involved in transcriptional regulation of hemolysin; non-specific DNA-binding protein which affects the production of multiple proteins YP_001589297.1 KEGG: sty:STY0515 9.0e-99 maA; maltose O-acetyltransferase K00661; COG: COG0110 Acetyltransferase (isoleucine patch superfamily); Psort location: cytoplasmic, score: 23 YP_001589298.1 COG: NOG07873 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001589299.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif YP_001589300.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_001589301.1 KEGG: mca:MCA1246 1.7e-32 methyltransferase CheR, putative K03412:K00575; COG: COG4943 Predicted signal transduction protein containing sensor and EAL domains; Psort location: endoplasmic reticulum, score: 9 YP_001589302.1 KEGG: eci:UTI89_C0482 2.6e-53 ybaZ; hypothetical protein YbaZ K07443; COG: COG3695 Predicted methylated DNA-protein cysteine methyltransferase; Psort location: cytoplasmic, score: 23 YP_001589303.1 COG: COG3126 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001589304.1 KEGG: sec:SC0507 2.4e-153 tesB; acyl-CoA THIoesterase II K01076; COG: COG1946 Acyl-CoA THIoesterase; Psort location: cytoplasmic, score: 23 YP_001589305.1 KEGG: ter:Tery_3993 1.8e-35 adenylate/guanylate cyclase K01769; COG: COG0004 Ammonia permease; Psort location: plasma membrane, score: 23 YP_001589306.1 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II 2 prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II 2 is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; functionally it is equivalent to protein P-II (GlnB), but itsexpression is driven by the presence of uridylyltransferase, nitrogen regulator I, and the absence of ammonia. YP_001589307.1 Psort location: nuclear, score: 23 YP_001589308.1 KEGG: cch:Cag_0453 6.7e-71 ATPase K06147; COG: COG1132 ABC-type multidrug transport system, ATPase and permease components; Psort location: endoplasmic reticulum, score: 9 YP_001589309.1 KEGG: reh:H16_A0776 5.7e-81 ABC-type transporter, ATPase and permease components: Prot2E family; COG: COG1132 ABC-type multidrug transport system, ATPase and permease components; Psort location: endoplasmic reticulum, score: 9 YP_001589310.1 COG: COG1522 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001589311.1 KEGG: sec:SC0500 1.5e-192 putative cysteine synthase/cystaTHIonine beta-synthase K01738; COG: COG0031 Cysteine synthase; Psort location: cytoplasmic, score: 23 YP_001589312.1 KEGG: aha:AHA_0482 1.0e-19 phosphatase YidA K01112; COG: COG0561 Predicted hydrolases of the HAD superfamily; Psort location: cytoplasmic, score: 23 YP_001589313.1 COG: COG4533 ABC-type uncharacterized transport system, periplasmic component; Psort location: cytoplasmic, score: 23 YP_001589314.1 YbaX; catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0), as one of the early reactions of quenosine biosynthesis; quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn, Asp, Tyr, and His YP_001589315.1 Psort location: cytoplasmic, score: 23 YP_001589316.1 KEGG: gbe:GbCGDNIH1_1102 5.0e-11 short-chain acyl-CoA hydrolase; COG: COG0824 Predicted THIoesterase; Psort location: cytoplasmic, score: 23 YP_001589317.1 KEGG: bur:Bcep18194_A5099 0.00031 RNA binding S1; COG: COG1555 DNA uptake protein and related DNA-binding proteins; Psort location: extracellular, including cell wall, score: 9 YP_001589318.1 KEGG: stm:STM0452 0. cypD; peptidyl prolyl isomerase K03770; COG: COG0760 Parvulin-like peptidyl-prolyl isomerase; Psort location: endoplasmic reticulum, score: 9 YP_001589319.1 histone-like DNA-binding protein YP_001589320.1 KEGG: stm:STM0450 0. lon; ATP-dependent protease Lon K01338; COG: COG0466 ATP-dependent Lon protease, bacterial type; Psort location: cytoplasmic, score: 23 YP_001589321.1 binds and unfolds substrates as part of the ClpXP protease YP_001589322.1 Psort location: cytoplasmic, score: 23 YP_001589323.1 Psort location: mitochondrial, score: 23 YP_001589324.1 KEGG: sec:SC0490 4.1e-126 clpP; proteolytic subunit of ClpA-ClpP ATP-dependent serine protease, heat shock protein F215 K01358; COG: COG0740 Protease subunit of ATP-dependent Clp proteases; Psort location: cytoplasmic, score: 23 YP_001589325.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_001589326.1 Psort location: mitochondrial, score: 23 YP_001589327.1 positive transcriptional regulator of morphogenetic pathway; controlling several genes involved in oxidative stress, acid stress, heat shock, osmotic shock, and carbon-starvation stress YP_001589328.1 Psort location: cytoplasmic, score: 23 YP_001589329.1 COG: COG3056 Uncharacterized lipoprotein; Psort location: cytoplasmic, score: 23 YP_001589330.1 in Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein YP_001589331.1 Psort location: endoplasmic reticulum, score: 9 YP_001589332.1 KEGG: sec:SC0485 4.9e-171 cyoA; cytochrome o ubiquinol oxidase subunit II K02297; COG: COG1622 Heme/copper-type cytochrome/quinol oxidases, subunit 2; Psort location: endoplasmic reticulum, score: 9 YP_001589333.1 KEGG: stt:t2418 0. cyoB; cytochrome o ubiquinol oxidase subunit I K02298; COG: COG0843 Heme/copper-type cytochrome/quinol oxidases, subunit 1; Psort location: plasma membrane, score: 23 YP_001589334.1 KEGG: sec:SC0483 2.3e-109 cyoC; cytochrome o ubiquinol oxidase subunit III K02299; COG: COG1845 Heme/copper-type cytochrome/quinol oxidase, subunit 3; Psort location: endoplasmic reticulum, score: 9 YP_001589335.1 KEGG: eci:UTI89_C0452 3.0e-52 cyoD; cytochrome o ubiquinol oxidase protein CyoD K02300; COG: COG3125 Heme/copper-type cytochrome/quinol oxidase, subunit 4; Psort location: endoplasmic reticulum, score: 9 YP_001589336.1 converts protoheme IX and farnesyl diphosphate to heme O YP_001589337.1 KEGG: eci:UTI89_C1133 1.3e-24 hypothetical protein; COG: COG0790 FOG: TPR repeat, SEL1 subfamily; Psort location: extracellular, including cell wall, score: 9 YP_001589338.1 KEGG: cch:Cag_1938 1.0e-16 Sel1-like repeat; COG: COG0790 FOG: TPR repeat, SEL1 subfamily; Psort location: extracellular, including cell wall, score: 9 YP_001589339.1 Psort location: nuclear, score: 23 YP_001589340.1 KEGG: shn:Shewana3_1692 5.1e-07 Xaa-His dipeptidase K01270; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001589341.1 putative nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription YP_001589342.1 KEGG: stm:STM0434 1.0e-145 apbA; 2-dehydropantoate 2-reductase K00077; COG: COG1893 Ketopantoate reductase; Psort location: cytoplasmic, score: 23 YP_001589343.1 KEGG: eci:UTI89_C0447 3.8e-61 THIJ; 4-methyl-5(B-hydroxyethyl)-THIazole monophosphate biosynthesis enzyme K03152; COG: COG0693 Putative intracellular protease/amidase; Psort location: endoplasmic reticulum, score: 9 YP_001589344.1 catalyzes the degradation of phosphonoacetaldehyde to acetaldehyde and phosphate YP_001589345.1 catalyzes the formation of phosphonoacetaldehyde from 2-aminoethylphosphonate and pyruvate YP_001589346.1 Psort location: cytoplasmic, score: 23 YP_001589347.1 KEGG: reh:H16_A3019 6.2e-11 hutC; histidine utilization repressor; COG: COG2188 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001589348.1 COG: COG1840 ABC-type Fe3+ transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001589349.1 KEGG: stm:STM0428 4.9e-194 phnT; 2-aminoethylphosphonate transporter,ATPase component K02052; COG: COG3842 ABC-type spermidine/putrescine transport systems, ATPase components; Psort location: cytoplasmic, score: 23 YP_001589350.1 KEGG: cdi:DIP0495 1.5e-11 putative molybdenum ABC transport system (integral membrane and ATP-binding proteins) K02017:K02018; COG: COG0555 ABC-type sulfate transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001589351.1 KEGG: ava:Ava_0243 2.3e-11 molybdate ABC transporter, permease protein K02018; COG: COG1177 ABC-type spermidine/putrescine transport system, permease component II; Psort location: endoplasmic reticulum, score: 23 YP_001589352.1 Required for the synthesis of the thiazole moiety YP_001589353.1 catalyzes the bidirectional exonucleolytic cleavage of DNA YP_001589354.1 KEGG: spt:SPA2300 1.2e-153 ispA; geranyltranstransferase K00795; COG: COG0142 Geranylgeranyl pyrophosphate synthase; Psort location: cytoplasmic, score: 23 YP_001589355.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_001589356.1 KEGG: eco:b0419 1.5e-160 yajO; predicted oxidoreductase, NAD(P)-binding; COG: COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001589357.1 hydrolyzes phosphatidylglycerophosphate to produce phosphatidylglycerol and phosphate YP_001589358.1 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP YP_001589359.1 Regulates rRNA biosynthesis by transcriptional antitermination YP_001589360.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_001589361.1 riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway; catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil YP_001589362.1 KEGG: eci:UTI89_C0435 2.4e-73 ybaD; hypothetical protein K07738; COG: COG1327 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains; Psort location: cytoplasmic, score: 23 YP_001589363.1 Psort location: cytoplasmic, score: 23 YP_001589364.1 COG: NOG07872 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001589365.1 COG: COG3248 Nucleoside-binding outer membrane protein; Psort location: extracellular, including cell wall, score: 9 YP_001589366.1 Psort location: cytoplasmic, score: 23 YP_001589367.1 Psort location: nuclear, score: 23 YP_001589368.1 Psort location: cytoplasmic, score: 23 YP_001589369.1 COG: NOG13275 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001589370.1 COG: COG2378 Predicted transcriptional regulator; Psort location: mitochondrial, score: 23 YP_001589371.1 KEGG: hma:rrnAC2504 0.00079 lgl; putative lactoyglutaTHIone lyase K01759; COG: COG3324 Predicted enzyme related to lactoylglutaTHIone lyase; Psort location: cytoplasmic, score: 23 YP_001589372.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_001589373.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane YP_001589374.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex YP_001589375.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) YP_001589376.1 Psort location: mitochondrial, score: 23 YP_001589377.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step YP_001589378.1 Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP YP_001589379.1 KEGG: stm:STM0402 8.0e-107 putative THIol - alkyl hydroperoxide reductase K03386; COG: COG0450 Peroxiredoxin; Psort location: cytoplasmic, score: 23 YP_001589380.1 KEGG: stm:STM0401 0. malZ; maltodextrin glucosidase K01187; COG: COG0366 Glycosidases; Psort location: cytoplasmic, score: 23 YP_001589381.1 cryptic permease that may be involved in the transport of proline across the inner membrane; in Salmonella typhimurium, the proY gene is silent unless overexpressed on a multicopy plasmid or activated by a proZ mutation YP_001589382.1 KEGG: rpb:RPB_2641 0.0012 V-type H(+)-translocating pyrophosphatase K01507; COG: COG1114 Branched-chain amino acid permeases; Psort location: plasma membrane, score: 23 YP_001589383.1 Psort location: cytoplasmic, score: 23 YP_001589384.1 membrane-associated histidine protein kinase that phosphorylates phoB in response to environmental signals as part of the two-component phosphate regulatory system phoR/phoB YP_001589385.1 Psort location: mitochondrial, score: 23 YP_001589386.1 two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB YP_001589387.1 Psort location: cytoplasmic, score: 23 YP_001589388.1 with SbcC cleaves DNA hairpin structure, also has 5' single-strand endonuclease activity YP_001589389.1 with SbcD cleaves DNA hairpin structures; also has 5' single-strand endonuclease activity YP_001589390.1 member of the major facilitator superfamily (MFS) of transporters; unknown function; may be associated with transport or processing of arabinose polymers YP_001589391.1 catalyzes phosphorylation of fructose; cytosolic enzyme YP_001589392.1 Required for efficient pilin antigenic variation YP_001589393.1 COG: COG3123 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001589394.1 COG: NOG06193 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001589395.1 COG: NOG13867 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001589396.1 type II enzyme similar to type I but differentially regulated and with a lower Km; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis YP_001589397.1 COG: COG1671 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001589398.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate YP_001589399.1 catalyzes the conversion of 2 GTP into c-di-GMP; adrA overexpression induces cellulose biosynthesis, cell adherence to abiotic surfaces and swimming and swarming motility; AdrA acts post-transcriptionally on the bcsABZC operon activating cellulose biosynthesis YP_001589400.1 COG: NOG17162 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001589401.1 Psort location: nuclear, score: 23 YP_001589402.1 COG: NOG14126 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589403.1 Psort location: cytoplasmic, score: 23 YP_001589404.1 KEGG: bps:BPSS1635 5.7e-06 probable class III aminotransferase K00836; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001589405.1 COG: COG3921 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001589406.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_001589407.1 COG: NOG15537 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001589408.1 Psort location: nuclear, score: 23 YP_001589409.1 COG: NOG11448 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001589410.1 COG: NOG06003 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001589411.1 in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope YP_001589412.1 Psort location: cytoplasmic, score: 23 YP_001589413.1 this protein has no known enzymatic function YP_001589414.1 COG: NOG06782 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589415.1 KEGG: eci:UTI89_C0334 1.2e-46 hypothetical protein; COG: COG3468 Type V secretory pathway, adhesin AidA; Psort location: extracellular, including cell wall, score: 9 YP_001589416.1 Psort location: nuclear, score: 23 YP_001589417.1 Psort location: cytoplasmic, score: 23 YP_001589418.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_001589419.1 catalyzes the formation of propionyl-CoA using propionate as a substrate; PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A; not expressed in Escherichia coli when grown on propionate/minimal media; ATP-dependent YP_001589420.1 functions in propionate metabolism; involved in isomerization of (2S,3S)-methylcitrate to (2R,3S)-methylisocitrate; also encodes minor aconitase or dehydratase activity; aconitase C YP_001589421.1 catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity YP_001589422.1 Psort location: cytoplasmic, score: 23 YP_001589423.1 catalyzes the formation of pyruvate and succinate from 2-methylisocitrate YP_001589424.1 KEGG: reh:H16_A1904 6.2e-84 prpR; propionate catabolism activator K01529; COG: COG1221 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain; Psort location: cytoplasmic, score: 23 YP_001589425.1 COG: NOG14127 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001589426.1 COG: COG1280 Putative threonine efflux protein; Psort location: cytoplasmic, score: 23 YP_001589427.1 KEGG: sgl:SG1838 6.3e-12 putative mannonate dehydratase K01686; COG: COG1629 Outer membrane receptor proteins, mostly Fe transport; Psort location: cytoplasmic, score: 23 YP_001589428.1 KEGG: rle:RL0442 3.1e-07 ada; putative ADA regulator (methylated-DNA--protein-cysteine methyltransferase) K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001589429.1 Psort location: endoplasmic reticulum, score: 9 YP_001589430.1 KEGG: stm:STM0361 4.2e-181 cytochrome BD2 subunit II K00426; COG: COG1294 Cytochrome bd-type quinol oxidase, subunit 2; Psort location: plasma membrane, score: 23 YP_001589431.1 KEGG: stm:STM0360 6.4e-256 cytochrome BD2 subunit I K00425; COG: COG1271 Cytochrome bd-type quinol oxidase, subunit 1; Psort location: plasma membrane, score: 23 YP_001589432.1 Psort location: cytoplasmic, score: 23 YP_001589433.1 KEGG: sec:SC0399 0. res; DNA restriction (DNA helicase K01156; COG: COG3587 Restriction endonuclease; Psort location: cytoplasmic, score: 23 YP_001589434.1 KEGG: sty:STY0388 0. mod; type III restriction-modification system StyLTI enzyme mod K07316; COG: COG2189 Adenine specific DNA methylase Mod; Psort location: cytoplasmic, score: 23 YP_001589435.1 KEGG: cal:orf19.3668 1.1e-07 HGT2; hexose transporter K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001589436.1 COG: NOG35886 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589437.1 KEGG: aha:AHA_3827 3.4e-05 mercuric reductase (Hg(II) reductase) K00520; COG: COG2608 Copper chaperone; Psort location: cytoplasmic, score: 23 YP_001589438.1 KEGG: eci:UTI89_C3737 7.4e-17 yhdM; Zn(II)-responsive regulator of ZntA; COG: COG0789 Predicted transcriptional regulators; Psort location: nuclear, score: 23 YP_001589439.1 KEGG: stm:STM0353 0. putative cation transport ATPase K01529; COG: COG2217 Cation transport ATPase; Psort location: plasma membrane, score: 23 YP_001589440.1 Psort location: nuclear, score: 23 YP_001589441.1 COG: COG0845 Membrane-fusion protein; Psort location: mitochondrial, score: 23 YP_001589442.1 KEGG: eci:UTI89_C2351 7.4e-120 yegO; hypothetical protein YegO K07789; COG: COG0841 Cation/multidrug efflux pump; Psort location: plasma membrane, score: 23 YP_001589443.1 COG: COG1538 Outer membrane protein; Psort location: cytoplasmic, score: 23 YP_001589444.1 COG: NOG14652 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001589445.1 COG: NOG30160 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001589446.1 COG: COG2771 DNA-binding HTH domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001589447.1 COG: COG3637 Opacity protein and related surface antigens; Psort location: extracellular, including cell wall, score: 9 YP_001589448.1 COG: NOG26028 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001589449.1 COG: NOG26665 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001589450.1 KEGG: shn:Shewana3_3829 3.1e-37 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) K01745; COG: COG2200 FOG: EAL domain; Psort location: cytoplasmic, score: 23 YP_001589451.1 Psort location: nuclear, score: 23 YP_001589452.1 COG: NOG30070 non supervised orthologous group; Psort location: golgi, score: 9 YP_001589453.1 COG: NOG20074 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001589454.1 Psort location: cytoplasmic, score: 23 YP_001589455.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001589456.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: extracellular, including cell wall, score: 9 YP_001589457.1 COG: COG3188 P pilus assembly protein, porin PapC; Psort location: extracellular, including cell wall, score: 9 YP_001589458.1 COG: NOG07902 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001589459.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: nuclear, score: 23 YP_001589460.1 Psort location: cytoplasmic, score: 23 YP_001589461.1 KEGG: shn:Shewana3_3435 0.0030 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001589462.1 KEGG: reh:H16_A0197 3.7e-70 predicted hydrolase or acyltransferase; COG: COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily); Psort location: cytoplasmic, score: 23 YP_001589463.1 KEGG: rha:RHA1_ro10314 4.7e-63 probable hydratase K01726; COG: COG0179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway); Psort location: cytoplasmic, score: 23 YP_001589464.1 KEGG: stm:STM0330 6.8e-110 putative 3-isopropylmalate isomerase (dehydratase), subunit with LeuC K01704; COG: COG0066 3-isopropylmalate dehydratase small subunit; Psort location: cytoplasmic, score: 23 YP_001589465.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_001589466.1 KEGG: shn:Shewana3_1692 9.7e-31 Xaa-His dipeptidase K01270; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001589467.1 COG: NOG09762 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589468.1 KEGG: sco:SCO3318 0.00040 hemC, SCE68.16c; putative porphobilinogen deaminase K01749; COG: NOG06036 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589469.1 KEGG: nwi:Nwi_0782 7.1e-12 integrase, catalytic region K00986; COG: COG2801 Transposase and inactivated derivatives; Psort location: mitochondrial, score: 23 YP_001589470.1 COG: COG0582 Integrase; Psort location: nuclear, score: 23 YP_001589471.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway YP_001589472.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis YP_001589473.1 Psort location: cytoplasmic, score: 23 YP_001589474.1 Psort location: endoplasmic reticulum, score: 9 YP_001589475.1 COG: COG3203 Outer membrane protein (porin); Psort location: cytoplasmic, score: 23 YP_001589476.1 involved in the expression of csgBA which is involved in curli formation; interacts with sigmaS YP_001589477.1 forms a 1:1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation YP_001589478.1 catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively YP_001589479.1 KEGG: stm:STM0316 5.2e-261 pepD; aminoacyl-histidine dipeptidase K01270; COG: COG2195 Di- and tripeptidases; Psort location: cytoplasmic, score: 23 YP_001589480.1 similar to release factor 1 and 2 YP_001589481.1 mutations in this gene result in a compromised ability for drug-inducible mexXY expression; expression is inducible by the same ribosome-targeting agents that induce mexXY YP_001589482.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function YP_001589483.1 COG: COG3034 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001589484.1 KEGG: reh:H16_A0476 1.3e-67 predicted glutamine amidotransferase class II; COG: COG0121 Predicted glutamine amidotransferase; Psort location: cytoplasmic, score: 23 YP_001589485.1 catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate YP_001589486.1 functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA YP_001589487.1 KEGG: eco:b0219 8.8e-117 yafV; predicted C-N hydrolase family amidase, NAD(P)-binding; COG: COG0388 Predicted amidohydrolase; Psort location: cytoplasmic, score: 23 YP_001589488.1 COG: COG3678 P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein; Psort location: cytoplasmic, score: 23 YP_001589489.1 Psort location: cytoplasmic, score: 23 YP_001589490.1 COG: COG3637 Opacity protein and related surface antigens; Psort location: extracellular, including cell wall, score: 9 YP_001589491.1 Psort location: cytoplasmic, score: 23 YP_001589492.1 KEGG: shn:Shewana3_3435 9.6e-05 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001589493.1 Psort location: cytoplasmic, score: 23 YP_001589494.1 Psort location: cytoplasmic, score: 23 YP_001589495.1 KEGG: chu:CHU_0603 1.1e-21 polysaccharide deacetylase K01452; COG: COG0726 Predicted xylanase/chitin deacetylase; Psort location: cytoplasmic, score: 23 YP_001589496.1 COG: NOG27222 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001589497.1 COG: COG3188 P pilus assembly protein, porin PapC; Psort location: extracellular, including cell wall, score: 9 YP_001589498.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: cytoplasmic, score: 23 YP_001589499.1 Psort location: cytoplasmic, score: 23 YP_001589500.1 COG: NOG27575 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001589501.1 Psort location: cytoplasmic, score: 23 YP_001589502.1 KEGG: nwi:Nwi_0782 0.0063 integrase, catalytic region K00986; COG: COG2801 Transposase and inactivated derivatives; Psort location: nuclear, score: 23 YP_001589503.1 COG: COG0542 ATPases with chaperone activity, ATP-binding subunit; Psort location: cytoplasmic, score: 23 YP_001589504.1 Psort location: nuclear, score: 23 YP_001589505.1 Psort location: cytoplasmic, score: 23 YP_001589506.1 Psort location: cytoplasmic, score: 23 YP_001589507.1 Psort location: nuclear, score: 23 YP_001589508.1 COG: NOG14023 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589509.1 Psort location: cytoplasmic, score: 23 YP_001589510.1 Psort location: nuclear, score: 23 YP_001589511.1 Psort location: cytoplasmic, score: 23 YP_001589512.1 COG: NOG24492 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589513.1 Psort location: cytoplasmic, score: 23 YP_001589514.1 Psort location: cytoplasmic, score: 23 YP_001589515.1 Psort location: cytoplasmic, score: 23 YP_001589516.1 Psort location: nuclear, score: 23 YP_001589517.1 KEGG: hpa:HPAG1_0820 3.0e-05 GTP-binding protein-like protein K00058; COG: COG3596 Predicted GTPase; Psort location: cytoplasmic, score: 23 YP_001589518.1 Psort location: cytoplasmic, score: 23 YP_001589519.1 COG: COG2378 Predicted transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001589520.1 Psort location: extracellular, including cell wall, score: 9 YP_001589521.1 Psort location: nuclear, score: 23 YP_001589522.1 COG: COG2378 Predicted transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001589523.1 Psort location: extracellular, including cell wall, score: 9 YP_001589524.1 COG: NOG22018 non supervised orthologous group; Psort location: vesicles of secretory system, score: 9 YP_001589525.1 Psort location: endoplasmic reticulum, score: 9 YP_001589526.1 Psort location: cytoplasmic, score: 23 YP_001589527.1 Psort location: cytoplasmic, score: 23 YP_001589528.1 COG: COG2003 DNA repair proteins; Psort location: extracellular, including cell wall, score: 9 YP_001589529.1 Psort location: cytoplasmic, score: 23 YP_001589530.1 Psort location: mitochondrial, score: 23 YP_001589531.1 COG: NOG14217 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001589532.1 COG: NOG14217 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589533.1 Psort location: cytoplasmic, score: 23 YP_001589534.1 COG: NOG14666 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589535.1 COG: NOG28061 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589536.1 Psort location: cytoplasmic, score: 23 YP_001589537.1 COG: NOG06321 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589539.1 Psort location: mitochondrial, score: 23 YP_001589540.1 3'-5' exonuclease of DNA polymerase III YP_001589541.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids YP_001589542.1 KEGG: vfi:VF1937 3.8e-45 methyltransferase K00599; COG: COG0500 SAM-dependent methyltransferases; Psort location: extracellular, including cell wall, score: 9 YP_001589543.1 catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione; plays an important role in cellular detoxification using glutathione YP_001589544.1 catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; may play a role in recycling muropeptides during cell division and/or cell elongation; in Helicobacter pylori MltD is a endolytic transglycosylase involved mainly in the rearrangement of the peptidoglycan layer of the bacterial cell wall YP_001589545.1 KEGG: eci:UTI89_C0229 2.3e-100 yafE; conserved hypothetical protein YafE K00599; COG: COG0500 SAM-dependent methyltransferases; Psort location: cytoplasmic, score: 23 YP_001589546.1 COG: COG3021 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001589547.1 Psort location: nuclear, score: 23 YP_001589548.1 KEGG: eci:UTI89_C5041 1.4e-09 yjiJ; hypothetical protein YjiJ K00403; COG: COG2814 Arabinose efflux permease; Psort location: plasma membrane, score: 23 YP_001589549.1 KEGG: shn:Shewana3_3435 1.2e-10 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001589550.1 catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid YP_001589551.1 Psort location: cytoplasmic, score: 23 YP_001589552.1 Psort location: mitochondrial, score: 23 YP_001589553.1 Psort location: nuclear, score: 23 YP_001589554.1 KEGG: eci:UTI89_C2925 0. clpB; heat shock protein K03695; COG: COG0542 ATPases with chaperone activity, ATP-binding subunit; Psort location: cytoplasmic, score: 23 YP_001589555.1 Psort location: nuclear, score: 23 YP_001589556.1 COG: COG1496 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001589557.1 responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA YP_001589558.1 with YaeT, NlpB and YfgL forms a complex involved in the proper assembly and/or targeting of OMPs to the outer membrane; involved in resistance to ampicillin and tetracycline YP_001589559.1 Psort location: nuclear, score: 23 YP_001589560.1 associated with 30S ribosomal subunit; interferes with translation elongation YP_001589561.1 Psort location: cytoplasmic, score: 23 YP_001589562.1 catalyzing the formation of prephenate from chorismate and the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis YP_001589563.1 KEGG: pub:SAR11_0777 1.2e-23 gnl; gluconolactonase K01053; COG: COG3386 Gluconolactonase; Psort location: cytoplasmic, score: 23 YP_001589564.1 catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis YP_001589565.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive YP_001589566.1 Psort location: cytoplasmic, score: 23 YP_001589567.1 COG: NOG17158 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001589568.1 KEGG: vfi:VFA0057 1.2e-16 sensor protein; COG: COG2199 FOG: GGDEF domain; Psort location: endoplasmic reticulum, score: 23 YP_001589569.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_001589570.1 KEGG: sec:SC2675 6.9e-101 trmD; tRNA (guanine-7-)-methyltransferase K00554; COG: COG0336 tRNA-(guanine-N1)-methyltransferase; Psort location: cytoplasmic, score: 23 YP_001589571.1 Psort location: cytoplasmic, score: 23 YP_001589572.1 Essential for efficient processing of 16S rRNA YP_001589573.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_001589574.1 Psort location: mitochondrial, score: 23 YP_001589575.1 with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins YP_001589576.1 KEGG: ece:Z3906m 1.8e-196 yfjD; uncharacterized CBS domain-containing protein K00638; COG: COG4536 Putative Mg2+ and Co2+ transporter CorB; Psort location: endoplasmic reticulum, score: 23 YP_001589577.1 COG: NOG26210 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589578.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor YP_001589579.1 KEGG: yps:YPTB0915 0.00064 sbcC; putative ATP-dependent dsDNA exonuclease K03546; COG: COG0497 ATPase involved in DNA repair; Psort location: cytoplasmic, score: 23 YP_001589580.1 COG: COG2913 Small protein A (tmRNA-binding); Psort location: extracellular, including cell wall, score: 9 YP_001589581.1 Psort location: nuclear, score: 23 YP_001589582.1 COG: COG2914 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001589583.1 KEGG: tfu:Tfu_1222 0.0015 actinorhodin polyketide synthase bifunctional cyclase/dehydratase K05554; COG: COG2867 Oligoketide cyclase/lipid transport protein; Psort location: cytoplasmic, score: 23 YP_001589584.1 Psort location: cytoplasmic, score: 23 YP_001589585.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_001589586.1 Psort location: endoplasmic reticulum, score: 9 YP_001589587.1 Psort location: cytoplasmic, score: 23 YP_001589588.1 Psort location: cytoplasmic, score: 23 YP_001589589.1 KEGG: chu:CHU_1906 1.2e-52 CHU large protein, possible SAP or adhesin AidA-related K01238; COG: COG5295 Autotransporter adhesin; Psort location: endoplasmic reticulum, score: 9 YP_001589590.1 COG: COG1538 Outer membrane protein; Psort location: nuclear, score: 23 YP_001589591.1 KEGG: pen:PSEEN0144 2.5e-96 type I toxin efflux ATP-binding protein; COG: COG2274 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain; Psort location: endoplasmic reticulum, score: 9 YP_001589592.1 COG: COG0845 Membrane-fusion protein; Psort location: endoplasmic reticulum, score: 9 YP_001589593.1 COG: COG0582 Integrase; Psort location: nuclear, score: 23 YP_001589594.1 KEGG: pfl:PFL_1789 3.3e-07 HAD-superfamily hydrolase K01091; COG: COG1011 Predicted hydrolase (HAD superfamily); Psort location: cytoplasmic, score: 23 YP_001589595.1 KEGG: mlo:mll8078 2.1e-05 3',5'-cyclic-nucleotide phosphodiesterase K01120; COG: COG1409 Predicted phosphohydrolases; Psort location: cytoplasmic, score: 23 YP_001589596.1 Psort location: cytoplasmic, score: 23 YP_001589597.1 COG: NOG18557 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589598.1 COG: NOG23021 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001589599.1 COG: NOG23022 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001589600.1 Psort location: cytoplasmic, score: 23 YP_001589601.1 Psort location: mitochondrial, score: 23 YP_001589602.1 COG: COG3311 Predicted transcriptional regulator; Psort location: nuclear, score: 23 YP_001589603.1 Psort location: mitochondrial, score: 23 YP_001589604.1 COG: NOG20798 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589605.1 COG: NOG32339 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589606.1 COG: NOG29857 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001589607.1 KEGG: sty:STY4832 0. Bacteriophage P4 DNA primase; COG: COG4643 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001589608.1 Psort location: mitochondrial, score: 23 YP_001589609.1 Psort location: nuclear, score: 23 YP_001589610.1 COG: COG0582 Integrase; Psort location: nuclear, score: 23 YP_001589611.1 COG: NOG06093 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589612.1 COG: COG0433 Predicted ATPase; Psort location: mitochondrial, score: 23 YP_001589613.1 COG: NOG18557 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001589614.1 Psort location: cytoplasmic, score: 23 YP_001589615.1 Psort location: nuclear, score: 23 YP_001589616.1 COG: NOG19478 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589617.1 Psort location: cytoskeletal, score: 9 YP_001589618.1 COG: NOG35293 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001589619.1 structural flagella protein; individual Salmonella serotypes usually alternate between the production of 2 antigenic forms of flagella, termed phase 1 and phase 2, each specified by separate structural genes YP_001589620.1 Psort location: cytoplasmic, score: 23 YP_001589621.1 COG: COG1961 Site-specific recombinases, DNA invertase Pin homologs; Psort location: cytoplasmic, score: 23 YP_001589622.1 Psort location: cytoplasmic, score: 23 YP_001589623.1 Psort location: mitochondrial, score: 23 YP_001589624.1 KEGG: eci:UTI89_C1122 1.2e-176 iroB; putative glucosyltransferase K00754; COG: COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase; Psort location: extracellular, including cell wall, score: 9 YP_001589625.1 KEGG: fal:FRAAL1741 1.2e-204 putative ABC transporter ATP-binding protein; COG: COG1132 ABC-type multidrug transport system, ATPase and permease components; Psort location: plasma membrane, score: 23 YP_001589626.1 KEGG: btk:BT9727_2470 6.0e-06 probable esterase K07214; COG: COG2382 Enterochelin esterase and related enzymes; Psort location: mitochondrial, score: 23 YP_001589627.1 KEGG: btk:BT9727_3479 2.4e-20 possible esterase; COG: COG2819 Predicted hydrolase of the alpha/beta superfamily; Psort location: nuclear, score: 23 YP_001589628.1 Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space YP_001589629.1 KEGG: tel:tlr1326 2.7e-07 serine/threonine protein kinase K08884; COG: COG1357 Uncharacterized low-complexity proteins; Psort location: nuclear, score: 23 YP_001589630.1 Psort location: mitochondrial, score: 23 YP_001589631.1 COG: COG2990 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001589632.1 Psort location: nuclear, score: 23 YP_001589633.1 Psort location: cytoplasmic, score: 23 YP_001589634.1 COG: NOG11449 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001589635.1 Psort location: mitochondrial, score: 23 YP_001589636.1 Psort location: cytoplasmic, score: 23 YP_001589637.1 COG: COG3376 High-affinity nickel permease; Psort location: endoplasmic reticulum, score: 9 YP_001589638.1 KEGG: stm:STM2784 2.6e-250 tctE; tricarboxylic transport: regulatory protein K07649; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 9 YP_001589639.1 KEGG: rha:RHA1_ro05622 1.8e-36 response regulator (protein-glutamate methylesterase) K07669; COG: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; Psort location: cytoplasmic, score: 23 YP_001589640.1 COG: NOG33077 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001589641.1 COG: COG3181 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001589642.1 COG: NOG11450 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001589643.1 KEGG: psp:PSPPH_3121 0.0040 nuoN; NADH-quinone oxidoreductase, N subunit K00343; COG: COG3333 Uncharacterized protein conserved in bacteria; Psort location: plasma membrane, score: 23 YP_001589644.1 Psort location: cytoplasmic, score: 23 YP_001589645.1 in Escherichia coli this gene is induced by carbon starvation and depends on sigma S and cAMP-CRP; the structure of the Gab protein shows it is a member of non-heme iron (II)-dependent oxygenase superfamily which includes clavamini acid synthases; forms homotetramers in solution YP_001589646.1 catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate YP_001589647.1 catalyzes the formation of succinate from succinate semialdehyde; NADP dependent YP_001589648.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate YP_001589649.1 KEGG: eci:UTI89_C0120 1.3e-74 aroP; aromatic amino acid transport protein AroP K03293; COG: COG1113 Gamma-aminobutyrate permease and related permeases; Psort location: plasma membrane, score: 23 YP_001589650.1 regulator of gab gene expression YP_001589651.1 KEGG: atu:Atu3770 0.0012 5'-nucleotidase K01081; COG: COG1652 Uncharacterized protein containing LysM domain; Psort location: cytoplasmic, score: 23 YP_001589652.1 COG: COG0401 Uncharacterized homolog of Blt101; Psort location: cytoplasmic, score: 23 YP_001589653.1 KEGG: reh:H16_A2208 1.7e-06 rhodanese-like: transcriptional regulator, ArsR family; COG: COG0640 Predicted transcriptional regulators; Psort location: nuclear, score: 23 YP_001589654.1 KEGG: azo:azo2810 2.4e-11 conserved hypothetical protein K01010; COG: COG0607 Rhodanese-related sulfurtransferase; Psort location: endoplasmic reticulum, score: 9 YP_001589655.1 COG: NOG35541 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589656.1 COG: COG2916 DNA-binding protein H-NS; Psort location: mitochondrial, score: 23 YP_001589657.1 Psort location: cytoplasmic, score: 23 YP_001589658.1 Psort location: nuclear, score: 23 YP_001589659.1 COG: NOG11269 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001589660.1 COG: NOG09772 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589661.1 COG: COG4575 Uncharacterized conserved protein; Psort location: vesicles of secretory system, score: 23 YP_001589662.1 KEGG: eci:UTI89_C3030 1.2e-169 hypothetical protein K00375; COG: COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs; Psort location: cytoplasmic, score: 23 YP_001589663.1 KEGG: msm:MSMEG_6370 1.7e-19 pcaC; 4-carboxymuconolactone decarboxylase K01607; COG: COG2128 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001589664.1 COG: NOG34989 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001589665.1 KEGG: vfi:VFA1040 0.00024 glutaredoxin K00435; COG: COG0695 Glutaredoxin and related proteins; Psort location: cytoplasmic, score: 23 YP_001589666.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF YP_001589667.1 Catalyzes the rate-limiting step in dNTP synthesis YP_001589668.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE YP_001589669.1 with ProWX is involved in the high-affinity uptake of glycine betaine YP_001589670.1 with ProVX is involved in the high-affinity uptake of glycine betaine YP_001589671.1 with ProVW, part of the high-affinity transport system for the osmoprotectant glycine betaine YP_001589672.1 Psort location: mitochondrial, score: 23 YP_001589673.1 KEGG: shn:Shewana3_1692 3.7e-17 Xaa-His dipeptidase K01270; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001589674.1 Psort location: nuclear, score: 23 YP_001589675.1 DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB YP_001589676.1 Psort location: mitochondrial, score: 23 YP_001589677.1 COG: COG1566 Multidrug resistance efflux pump; Psort location: endoplasmic reticulum, score: 9 YP_001589678.1 KEGG: sgl:SG1466 5.5e-07 deTHIobiotin synthase K01935; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001589679.1 COG: NOG06288 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001589680.1 Psort location: cytoplasmic, score: 23 YP_001589681.2 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2 YP_001589682.1 involved in the first step of glutathione biosynthesis YP_001589683.1 COG: COG1238 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001589684.1 YqaB; catalyzes the dephosphorylation of fructose 1-phosphate, 6-phosphogluconate and p-nitrophenyl phosphate (pNPP); presents beta-phosphoglucomutase activity at a lower extent YP_001589686.1 Psort location: nuclear, score: 23 YP_001589687.1 affects carbohydrate metabolism; has regulatory role in many processes YP_001589688.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001589689.1 Psort location: cytoplasmic, score: 23 YP_001589690.1 Psort location: nuclear, score: 23 YP_001589691.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities YP_001589692.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_001589693.1 COG: COG1546 Uncharacterized protein (competence- and mitomycin-induced); Psort location: cytoplasmic, score: 23 YP_001589694.1 membrane-bound lytic murein transglycosylase B; catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan YP_001589695.1 Psort location: nuclear, score: 23 YP_001589696.1 KEGG: sty:STY2953 3.9e-98 srlA; PTS system, glucitol/sorbitol-specific IIBC component K02782:K02783; COG: COG3730 Phosphotransferase system sorbitol-specific component IIC; Psort location: endoplasmic reticulum, score: 9 YP_001589697.1 KEGG: sec:SC2766 2.4e-169 srlE; PTS family, glucitol/sorbitol-specific IIB component, one of two IIC components K02782:K02783; COG: COG3732 Phosphotransferase system sorbitol-specific component IIBC; Psort location: endoplasmic reticulum, score: 9 YP_001589698.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_001589699.1 catalyzes the conversion of sorbitol 6-phosphate into fructose 6-phosphate YP_001589700.1 regulator for glucitol utilization YP_001589701.1 Psort location: mitochondrial, score: 23 YP_001589702.1 regulates genes involved in glucitol utilization YP_001589703.1 catalyzes the conversion of D-arabinose 5-phosphate to D-ribulose-5-phosphate YP_001589704.1 Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon YP_001589705.1 Psort location: endoplasmic reticulum, score: 9 YP_001589706.1 detoxifies nitric oxide using NADH YP_001589707.1 catalyzes the reduction of the rubredoxin moiety of nitric oxide reductase YP_001589708.1 KEGG: lil:LA3975 2.1e-06 acyP; acylphosphatase K01512; COG: COG0068 Hydrogenase maturation factor; Psort location: cytoplasmic, score: 23 YP_001589709.1 Psort location: nuclear, score: 23 YP_001589710.1 involved in electron transport from formate to hydrogen YP_001589711.1 Psort location: cytoplasmic, score: 23 YP_001589712.1 COG: NOG07882 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001589713.1 involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE YP_001589714.1 KEGG: eci:UTI89_C3081 1.8e-63 hycH; formate hydrogenlyase maturation protein HycH; COG: NOG09848 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589715.1 KEGG: eci:UTI89_C3082 1.4e-132 hycG; formate hydrogenlyase subunit 7; COG: COG3260 Ni,Fe-hydrogenase III small subunit; Psort location: cytoplasmic, score: 23 YP_001589716.1 electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate YP_001589717.1 KEGG: eci:UTI89_C3084 0. hycE; formate hydrogenlyase subunit 5 precursor; COG: COG3261 Ni,Fe-hydrogenase III large subunit; Psort location: cytoplasmic, score: 23 YP_001589718.1 KEGG: eci:UTI89_C3085 1.5e-144 hycD; membrane-spanning protein of formate hydrogenase; COG: COG0650 Formate hydrogenlyase subunit 4; Psort location: plasma membrane, score: 23 YP_001589719.1 catalyzes the oxidation of formate to carbon dioxide and molecular hydrogen; formate hydrogenlyase comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (subunit 3) YP_001589720.1 KEGG: eci:UTI89_C3087 6.3e-107 hycB; formate hydrogenlyase subunit 2; COG: COG1142 Fe-S-cluster-containing hydrogenase components 2; Psort location: extracellular, including cell wall, score: 9 YP_001589721.1 Psort location: cytoplasmic, score: 23 YP_001589722.1 regulates several genes involved in the formate hydrogenlyase system; seems to prevent binding of FhlA transcriptional activator to the activator sequence of hyc operon YP_001589723.1 Psort location: cytoplasmic, score: 23 YP_001589724.1 plays a role in hydrogenase nickel cofactor insertion YP_001589725.1 GTP hydrolase involved in nickel liganding into hydrogenases YP_001589726.1 HypC; accessory protein necessary for maturation of the hydrogenase isoforms 1, 2 and 3; forms a complex with HypD, HypE, and HypF proteins, which is the site of ligand biosynthesis and attachment to the iron atom of the NiFe site in the hydrogenase YP_001589727.1 COG: COG0409 Hydrogenase maturation factor; Psort location: cytoplasmic, score: 23 YP_001589728.1 KEGG: cch:Cag_0556 4.0e-80 hypE; hydrogenase expression/formation protein HypE K04655; COG: COG0309 Hydrogenase maturation factor; Psort location: cytoplasmic, score: 23 YP_001589729.1 Psort location: nuclear, score: 23 YP_001589730.1 KEGG: eci:UTI89_C3094 0. fhlA; formate hydrogenlyase transcriptional activator K01768; COG: COG3604 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains; Psort location: cytoplasmic, score: 23 YP_001589731.1 COG: NOG16835 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001589732.1 Psort location: extracellular, including cell wall, score: 9 YP_001589733.1 COG: COG0803 ABC-type metal ion transport system, periplasmic component/surface adhesin; Psort location: extracellular, including cell wall, score: 9 YP_001589734.1 KEGG: rru:Rru_A2894 4.2e-85 ABC transporter component K02074; COG: COG1121 ABC-type Mn/Zn transport systems, ATPase component; Psort location: cytoplasmic, score: 23 YP_001589735.1 KEGG: pde:Pden_0699 0.0037 NADH dehydrogenase (quinone) K05903; COG: COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components; Psort location: plasma membrane, score: 23 YP_001589736.1 COG: COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components; Psort location: plasma membrane, score: 23 YP_001589737.1 COG: NOG33788 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001589738.1 COG: NOG25264 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589739.1 Psort location: nuclear, score: 23 YP_001589740.1 COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001589741.1 Psort location: cytoplasmic, score: 23 YP_001589742.1 Psort location: cytoplasmic, score: 23 YP_001589743.1 COG: NOG23015 non supervised orthologous group; Psort location: cytoskeletal, score: 9 YP_001589744.1 COG: NOG14128 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589745.1 COG: NOG14693 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589746.1 COG: COG4669 Type III secretory pathway, lipoprotein EscJ; Psort location: golgi, score: 9 YP_001589747.1 COG: NOG19625 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589748.1 COG: NOG14694 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001589749.1 COG: NOG07990 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001589750.1 Psort location: cytoplasmic, score: 23 YP_001589751.1 KEGG: bli:BL05281 0.0030 adaA; methylphosphotriester-DNA alkyltransferase and transcriptional regulator (AraC/XylS family) K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: nuclear, score: 23 YP_001589752.1 Activates the expression of invasion genes and activates the expression of prgHIJK which is part of the pathogenicity island 1 type III secretion system YP_001589753.1 KEGG: pmt:PMT1824 1.2e-06 possible soluble lytic transglycosylase K01238; COG: COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains); Psort location: extracellular, including cell wall, score: 9 YP_001589754.1 KEGG: ddi:DDB0217322 2.6e-07 hypothetical protein K01104; COG: NOG11499 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001589755.1 COG: NOG23656 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589756.1 COG: NOG30285 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589757.1 carries the fatty acid chain in fatty acid biosynthesis YP_001589758.1 KEGG: cal:orf19.4072 1.5e-05 HYR10; similar to cell surface flocculin K01186; COG: NOG06172 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001589759.1 COG: NOG06173 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001589760.1 Psort location: mitochondrial, score: 23 YP_001589761.1 KEGG: cal:orf19.4683 0.0016 MLP1; myosin-like protein involved in translocation of macromolecules between the nucleoplasm and the NPC K01553; COG: NOG10023 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001589762.1 KEGG: hsa:11113 0.00012 CIT; citron (rho-interacting, serine/threonine kinase 21) K08282; COG: NOG06175 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001589763.1 COG: COG0457 FOG: TPR repeat; Psort location: cytoplasmic, score: 23 YP_001589764.1 Required for surface presentation of invasion plasmid antigens; required for invasion and for secretion of the three ipa proteins YP_001589765.1 COG: COG4791 Type III secretory pathway, component EscT; Psort location: plasma membrane, score: 23 YP_001589766.1 COG: COG4794 Type III secretory pathway, component EscS; Psort location: endoplasmic reticulum, score: 9 YP_001589767.1 part of a type III secretory system probably involved in invasion into eukaryotic cells YP_001589768.1 involved in a secretory pathway responsible for the surface presentation of determinants needed for the entry of Salmonella species into mammalian cells YP_001589769.1 COG: NOG19627 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001589770.1 COG: NOG18535 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001589771.1 Invasion protein InvC; necessary for efficient entry of S.typhimurium into cultured epithelial cells. Probable catalytic subunit of a protein translocase YP_001589772.1 COG: NOG14129 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589773.1 COG: COG4789 Type III secretory pathway, component EscV; Psort location: endoplasmic reticulum, score: 9 YP_001589774.1 COG: NOG06182 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001589775.1 COG: COG1450 Type II secretory pathway, component PulD; Psort location: extracellular, including cell wall, score: 9 YP_001589776.1 COG: NOG14596 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589777.1 Psort location: nuclear, score: 23 YP_001589778.1 Psort location: cytoplasmic, score: 23 YP_001589779.1 COG: NOG28130 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001589780.1 COG: NOG27628 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589781.1 COG: NOG11501 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589782.1 Psort location: cytoplasmic, score: 23 YP_001589783.1 Psort location: cytoplasmic, score: 23 YP_001589784.1 COG: COG2963 Transposase and inactivated derivatives; Psort location: nuclear, score: 23 YP_001589785.1 Psort location: mitochondrial, score: 23 YP_001589786.1 COG: COG4453 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001589787.1 KEGG: sat:SYN_02693 1.6e-12 acetyltransferase K00680; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001589788.1 COG: NOG07938 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589789.1 Psort location: nuclear, score: 23 YP_001589790.1 KEGG: stm:STM2907 2.3e-118 pphB; serine/threonine specific protein phosphatase 2 K07314; COG: COG0639 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases; Psort location: cytoplasmic, score: 23 YP_001589791.1 COG: NOG29516 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001589792.1 Psort location: endoplasmic reticulum, score: 9 YP_001589793.1 Psort location: cytoplasmic, score: 23 YP_001589794.1 COG: NOG29516 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001589795.1 This protein performs the mismatch recognition step during the DNA repair process YP_001589796.1 COG: COG4460 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001589797.1 KEGG: ani:AN1180.2 1.3e-06 hypothetical protein K04428; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001589798.1 KEGG: shn:Shewana3_3435 1.8e-08 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: extracellular, including cell wall, score: 23 YP_001589799.1 KEGG: eci:UTI89_C3106 1.6e-62 ygbN; hypothetical permease YgbN K03299; COG: COG2610 H+/gluconate symporter and related permeases; Psort location: plasma membrane, score: 23 YP_001589800.1 KEGG: bma:BMAA0572 1.9e-75 hypothetical protein K00043; COG: COG0451 Nucleoside-diphosphate-sugar epimerases; Psort location: cytoplasmic, score: 23 YP_001589801.1 KEGG: stt:t2816 1.2e-135 hyi; putative hydroxypyruvate isomerase K01816; COG: COG3622 Hydroxypyruvate isomerase; Psort location: cytoplasmic, score: 23 YP_001589802.1 KEGG: eci:UTI89_C3104 1.2e-94 ygbL; hypothetical aldolase class II protein YgbL K01628; COG: COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases; Psort location: cytoplasmic, score: 23 YP_001589803.1 KEGG: art:Arth_1035 6.8e-08 4-hydroxythreonine-4-phosphate dehydrogenase K00097; COG: COG3395 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001589804.1 KEGG: stm:STM2918 9.8e-157 ygbJ; 3-hydroxyisobutyrate dehydrogenase K08319; COG: COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001589805.1 COG: COG1349 Transcriptional regulators of sugar metabolism; Psort location: cytoplasmic, score: 23 YP_001589806.1 COG: COG1846 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001589807.1 KEGG: sec:SC2851 3.0e-100 pad; putative flavoprotein K03186; COG: COG0163 3-polyprenyl-4-hydroxybenzoate decarboxylase; Psort location: extracellular, including cell wall, score: 9 YP_001589808.1 KEGG: gvi:gll3010 1.1e-52 3-octaprenyl-4-hydroxybenzoate carboxy-lyase UbiD K03182; COG: COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases; Psort location: cytoplasmic, score: 23 YP_001589809.1 COG: NOG14130 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001589810.1 outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus YP_001589811.1 Psort location: cytoplasmic, score: 23 YP_001589812.1 Psort location: nuclear, score: 23 YP_001589813.1 catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins YP_001589814.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate YP_001589815.1 catalyzes the modification of U13 in tRNA(Glu) YP_001589816.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate YP_001589817.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers YP_001589818.1 forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein YP_001589819.1 Psort location: mitochondrial, score: 23 YP_001589820.1 COG: NOG12170 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001589821.1 converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis YP_001589822.1 may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ YP_001589823.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP YP_001589824.1 catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3 YP_001589825.1 COG: COG1203 Predicted helicases; Psort location: cytoplasmic, score: 23 YP_001589826.1 Psort location: cytoplasmic, score: 23 YP_001589827.1 COG: NOG25864 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589828.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite YP_001589829.1 hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide YP_001589830.1 catalyzes the reduction of sulfite to sulfide in the biosynthesis of L-cysteine from sulfate; a flavoprotein with flavin reductase activity YP_001589831.1 Psort location: cytoplasmic, score: 23 YP_001589832.1 KEGG: sty:STY3077 1.6e-44 6-pyruvoyltetrahydropterin synthase K01737; COG: COG0720 6-pyruvoyl-tetrahydropterin synthase; Psort location: cytoskeletal, score: 9 YP_001589833.1 KEGG: bcz:BCZK3890 0.00082 zinc metallohydrolase, metallo-beta-lactamase family K01467; COG: COG1237 Metal-dependent hydrolases of the beta-lactamase superfamily II; Psort location: cytoplasmic, score: 23 YP_001589834.1 COG: NOG18411 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001589835.1 Psort location: mitochondrial, score: 23 YP_001589836.1 Psort location: cytoplasmic, score: 23 YP_001589837.1 KEGG: hpa:HPAG1_0914 3.5e-05 hypothetical protein K04071; COG: COG0602 Organic radical activating enzymes; Psort location: cytoplasmic, score: 23 YP_001589838.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_001589839.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_001589840.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era YP_001589841.1 Psort location: nuclear, score: 23 YP_001589842.1 Psort location: mitochondrial, score: 23 YP_001589843.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001589844.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: nuclear, score: 23 YP_001589845.1 COG: NOG13897 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001589846.1 COG: NOG15373 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001589847.1 COG: NOG23107 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589848.1 COG: NOG26780 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001589849.1 (p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP YP_001589850.1 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S] YP_001589851.1 part of the two-component regulatory system with UvrY; involved in the regulation of carbon metabolism via the csrA/csrB regulatory system YP_001589852.1 KEGG: stt:t2868 3.6e-198 glycerate kinase K00865; COG: COG1929 Glycerate kinase; Psort location: cytoplasmic, score: 23 YP_001589853.1 KEGG: sec:SC2900 2.3e-244 gudD; D-glucarate dehydratase K01706; COG: COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily; Psort location: vesicles of secretory system, score: 9 YP_001589854.1 KEGG: stm:STM2961 8.3e-247 ygcY; putative D-glucarate dehydratase K01706; COG: COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily; Psort location: cytoplasmic, score: 23 YP_001589855.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001589856.1 Psort location: cytoplasmic, score: 23 YP_001589857.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_001589858.1 catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp YP_001589859.1 KEGG: shn:Shewana3_2825 5.0e-11 dTDP-4-dehydrorhamnose 3,5-epimerase K01790; COG: COG3098 Uncharacterized protein conserved in bacteria; Psort location: cytoskeletal, score: 9 YP_001589860.1 putative SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function YP_001589861.1 catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis YP_001589862.1 KEGG: hch:HCH_00651 5.4e-133 predicted Rossmann fold nucleotide-binding protein K00052; COG: COG1611 Predicted Rossmann fold nucleotide-binding protein; Psort location: cytoplasmic, score: 23 YP_001589863.1 Psort location: nuclear, score: 23 YP_001589864.1 Psort location: mitochondrial, score: 23 YP_001589865.1 COG: COG0814 Amino acid permeases; Psort location: plasma membrane, score: 23 YP_001589866.1 KEGG: sec:SC2910 3.0e-242 sdaB; L-serine dehydratase (L-threonine deaminase 2) K01752; COG: COG1760 L-serine deaminase; Psort location: cytoplasmic, score: 23 YP_001589867.1 Psort location: nuclear, score: 23 YP_001589868.1 has 3'-5' exonuclease activity that preferentially acts on ssDNA; also 3'-phosphodiesterase activity at sites with 3' incised apurinic/apyrimidinic sites; can remove 3' phosphoglycolate groups YP_001589869.1 Psort location: nuclear, score: 23 YP_001589870.1 KEGG: stm:STM2973 9.0e-202 fucO; L-1,2-propanediol oxidoreductase K00048; COG: COG1454 Alcohol dehydrogenase, class IV; Psort location: cytoplasmic, score: 23 YP_001589871.1 catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate YP_001589872.1 Psort location: mitochondrial, score: 23 YP_001589873.1 Psort location: nuclear, score: 23 YP_001589874.1 COG: COG0738 Fucose permease; Psort location: plasma membrane, score: 23 YP_001589875.1 catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose YP_001589876.1 Psort location: nuclear, score: 23 YP_001589877.1 KEGG: sec:SC2917 1.5e-254 fucK; L-fuculokinase K00879; COG: COG1070 Sugar (pentulose and hexulose) kinases; Psort location: cytoplasmic, score: 23 YP_001589878.1 COG: COG4154 Fucose dissimilation pathway protein FucU; Psort location: extracellular, including cell wall, score: 9 YP_001589879.1 regulates expression of genes involved in L-fucose utilization YP_001589880.1 KEGG: vfi:VF0593 1.2e-119 methyltransferase; COG: COG2933 Predicted SAM-dependent methyltransferase; Psort location: cytoplasmic, score: 23 YP_001589881.1 COG: COG2363 Uncharacterized small membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001589882.1 Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence YP_001589883.1 COG: NOG14132 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001589884.1 KEGG: sec:SC2924 1.8e-212 csdA; putative selenocysteine lyase; COG: COG0520 Selenocysteine lyase; Psort location: cytoplasmic, score: 23 YP_001589885.1 KEGG: cps:CPS_2211 9.9e-15 putative selenocysteine lyase K02426; COG: COG2166 SufE protein probably involved in Fe-S center assembly; Psort location: cytoplasmic, score: 23 YP_001589886.1 Psort location: cytoplasmic, score: 23 YP_001589887.1 COG: COG2962 Predicted permeases; Psort location: plasma membrane, score: 23 YP_001589888.1 KEGG: cal:orf19.2115 4.7e-26 molybdopterin-converting factor; COG: COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and THIamine biosynthesis family 1; Psort location: cytoplasmic, score: 23 YP_001589889.1 membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues YP_001589890.1 KEGG: spt:SPA2856 1.4e-205 amiC; N-acetylmuramoyl-L-alanine amidase K01448; COG: COG0860 N-acetylmuramoyl-L-alanine amidase; Psort location: cytoplasmic, score: 23 YP_001589891.1 catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis YP_001589892.1 helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity YP_001589893.1 helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity YP_001589894.1 KEGG: stm:STM2995 0. ptr; protease III K01407; COG: COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like; Psort location: extracellular, including cell wall, score: 9 YP_001589895.1 catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination YP_001589896.1 COG: COG4967 Tfp pilus assembly protein PilV; Psort location: cytoplasmic, score: 23 YP_001589897.1 COG: NOG10274 non supervised orthologous group; Psort location: golgi, score: 9 YP_001589898.1 COG: COG4795 Type II secretory pathway, component PulJ; Psort location: cytoplasmic, score: 23 YP_001589899.1 COG: COG2165 Type II secretory pathway, pseudopilin PulG; Psort location: extracellular, including cell wall, score: 9 YP_001589901.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived YP_001589902.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein YP_001589903.1 Psort location: cytoplasmic, score: 23 YP_001589904.1 member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr YP_001589905.1 hydrolyzes diadenosine polyphosphate YP_001589906.1 Psort location: mitochondrial, score: 23 YP_001589907.1 Psort location: mitochondrial, score: 23 YP_001589908.1 MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair YP_001589909.1 COG: COG0861 Membrane protein TerC, possibly involved in tellurium resistance; Psort location: plasma membrane, score: 23 YP_001589910.1 COG: NOG13901 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001589911.1 Psort location: nuclear, score: 23 YP_001589912.1 complements the prephenate dehydrogenase dysfunction of an Escherichia coli tyrosine auxotroph strain; member of the aldo/keto reductase 2 family; crystal structure of purified Escherichia coli protein shows bound NADPH YP_001589913.1 KEGG: gme:Gmet_0086 1.2e-23 2-acyl-glycerophospho-ethanolamine acyltransferase K05939:K01909; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001589914.1 Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1 YP_001589915.1 Psort location: nuclear, score: 23 YP_001589916.1 controls transcription of galETKM YP_001589917.1 KEGG: efa:EF1922 1.2e-12 transcriptional regulator, LacI family/carbohydrate kinase, PfkB family protein K00852; COG: COG1609 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001589918.1 catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding YP_001589919.1 activates the transcription of the lysA gene encoding diaminopimelate decarboxylase YP_001589920.1 KEGG: eci:UTI89_C3244 5.6e-99 ygeA; hypothetical protein YgeA K01779; COG: COG1794 Aspartate racemase; Psort location: cytoplasmic, score: 23 YP_001589921.1 KEGG: cal:orf19.3526 5.9e-56 ITR2; myo-inositol transporter K08140; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001589922.1 catalyzes the formation of 3-dehydro-2-deoxy-D-gluconate from 2-deoxy-D-gluconate YP_001589923.1 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate YP_001589924.1 Psort location: cytoplasmic, score: 23 YP_001589925.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis YP_001589926.1 KEGG: shn:Shewana3_3435 2.9e-07 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001589927.1 COG: COG4125 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001589928.1 Psort location: endoplasmic reticulum, score: 9 YP_001589929.1 COG: COG0814 Amino acid permeases; Psort location: plasma membrane, score: 23 YP_001589930.1 COG: COG1937 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001589931.1 membrane protein conferring nickel and cobalt resistance YP_001589932.1 COG: NOG26180 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001589933.1 COG: NOG23750 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001589934.1 COG: NOG26105 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001589935.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: extracellular, including cell wall, score: 9 YP_001589936.1 COG: COG3188 P pilus assembly protein, porin PapC; Psort location: endoplasmic reticulum, score: 9 YP_001589937.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: endoplasmic reticulum, score: 9 YP_001589938.1 Psort location: cytoplasmic, score: 23 YP_001589939.1 Psort location: cytoplasmic, score: 23 YP_001589940.1 COG: NOG06207 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001589941.1 COG: COG3637 Opacity protein and related surface antigens; Psort location: mitochondrial, score: 23 YP_001589942.1 Psort location: endoplasmic reticulum, score: 9 YP_001589943.1 Psort location: cytoplasmic, score: 23 YP_001589944.1 stability determinant protein YP_001589945.1 COG: COG4456 Virulence-associated protein and related proteins; Psort location: cytoplasmic, score: 23 YP_001589946.1 COG: NOG31325 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001589947.1 Psort location: cytoplasmic, score: 23 YP_001589948.1 COG: NOG10019 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001589949.1 KEGG: eci:UTI89_C3250 3.9e-114 ygeR; hypothetical lipoprotein YgeR precursor; COG: COG0739 Membrane proteins related to metalloendopeptidases; Psort location: nuclear, score: 23 YP_001589950.1 Psort location: cytoplasmic, score: 23 YP_001589951.1 catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate YP_001589952.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_001589953.1 KEGG: reh:H16_A1169 2.4e-107 prfB; protein chain release factor B (RF-2); COG: COG1186 Protein chain release factor B; Psort location: cytoplasmic, score: 23 YP_001589954.1 5'-3' single-stranded-DNA-specific exonuclease YP_001589955.1 DsbC; periplasmic protein with protein disulfide isomerase activity; this protein also shows disulfide oxidoreductase activity YP_001589956.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_001589957.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic YP_001589958.1 COG: NOG09016 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001589959.1 COG: COG2938 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001589960.1 Psort location: cytoplasmic, score: 23 YP_001589961.1 physiological role is not clear; not essential for growth but mutants grow poorly; mutations suppress hda null mutations; may be involved in regulation of ATP-DnaA levels; may also be involved in regulation of tRNA modifications; can bind folic acid and tetrahydrofolate; forms a three domain ring-like structure with a central channel; structurally similar to DMGO protein from A. globiformis; shows sequence similarity to yeast CAF17 transcriptional regulator YP_001589962.1 KEGG: ath:At4g22330 0.0083 T10I14.160; alkaline phytoceramidase family / aPHC family K04711; COG: COG1272 Predicted membrane protein, hemolysin III homolog; Psort location: plasma membrane, score: 23 YP_001589963.1 COG: COG3097 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001589964.1 KEGG: stm:STM3051 6.4e-272 bglA; 6-phospho-beta-glucosidase A K01223; COG: COG2723 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase; Psort location: cytoplasmic, score: 23 YP_001589965.1 COG: NOG26511 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001589966.1 Psort location: nuclear, score: 23 YP_001589967.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine YP_001589968.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor YP_001589969.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein YP_001589970.1 Psort location: nuclear, score: 23 YP_001589971.1 Psort location: cytoplasmic, score: 23 YP_001589972.1 Psort location: cytoplasmic, score: 23 YP_001589973.1 KEGG: ecp:ECP_2899 2.4e-192 protein VisC; COG: COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases; Psort location: cytoplasmic, score: 23 YP_001589974.1 Psort location: nuclear, score: 23 YP_001589975.1 Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone YP_001589976.1 exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide YP_001589977.1 the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown YP_001589978.1 KEGG: shn:Shewana3_3505 4.1e-16 fructose-bisphosphatase K01086; COG: COG3027 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001589979.2 ygfA expression increases five to eight fold in Escherichia coli cells growing as biofilms; unknown function YP_001589980.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate YP_001589981.1 Psort location: nuclear, score: 23 YP_001589982.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway YP_001589983.1 Psort location: mitochondrial, score: 23 YP_001589984.1 specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport YP_001589985.1 Psort location: cytoplasmic, score: 23 YP_001589986.1 COG: COG2968 Uncharacterized conserved protein; Psort location: extracellular, including cell wall, score: 9 YP_001589987.1 Involved in the export of arginine YP_001589988.1 Psort location: cytoplasmic, score: 23 YP_001589989.1 participates in the regulation of osmotic pressure changes within the cel YP_001589990.2 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate YP_001589991.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_001589992.1 NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate YP_001589993.1 Psort location: mitochondrial, score: 23 YP_001589994.1 KEGG: cya:CYA_1151 5.6e-23 glmU; UDP-N-acetylglucosamine pyrophosphorylase K04042:K00972; COG: COG1661 Predicted DNA-binding protein with PD1-like DNA-binding motif; Psort location: cytoplasmic, score: 23 YP_001589995.1 COG: NOG07916 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001589996.1 COG: COG0619 ABC-type cobalt transport system, permease component CbiQ and related transporters; Psort location: endoplasmic reticulum, score: 9 YP_001589997.1 KEGG: tko:TK0719 1.3e-18 ABC-type molybdate transport system, ATPase component K02017; COG: COG1122 ABC-type cobalt transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001589998.1 KEGG: bcn:Bcen_4728 1.3e-26 ABC transporter related K02052; COG: COG1118 ABC-type sulfate/molybdate transport systems, ATPase component; Psort location: endoplasmic reticulum, score: 9 YP_001589999.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_001590000.1 Psort location: mitochondrial, score: 23 YP_001590001.1 KEGG: stt:t2997 3.6e-127 putative metalloprotease K07387; COG: COG0501 Zn-dependent protease with chaperone function; Psort location: extracellular, including cell wall, score: 9 YP_001590002.1 catalyzes the formation of putrescine from agmatine YP_001590003.1 KEGG: bur:Bcep18194_C7536 1.1e-22 alpha/beta hydrolase K00433; COG: COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily); Psort location: endoplasmic reticulum, score: 9 YP_001590004.1 Psort location: nuclear, score: 23 YP_001590005.1 COG: COG2731 Beta-galactosidase, beta subunit; Psort location: cytoplasmic, score: 23 YP_001590006.1 KEGG: stm:STM3081 1.3e-177 putative malate/L-lactate dehydrogenase K00025; COG: COG2055 Malate/L-lactate dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001590007.1 KEGG: eci:UTI89_C3438 6.1e-132 hypothetical zinc-type alcohol dehydrogenase-like protein YjjN; COG: COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases; Psort location: endoplasmic reticulum, score: 9 YP_001590008.1 KEGG: eci:UTI89_C3437 7.3e-168 hypothetical oxidoreductase YdfI; COG: COG0246 Mannitol-1-phosphate/altronate dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001590009.1 Psort location: cytoplasmic, score: 23 YP_001590010.1 Psort location: cytoplasmic, score: 23 YP_001590011.1 Psort location: cytoplasmic, score: 23 YP_001590012.1 KEGG: reh:H16_B1289 5.9e-05 phnF; regulator of phosphonate operon, GntR-family; COG: COG2186 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001590013.1 COG: NOG14091 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001590014.1 catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis YP_001590015.1 COG: NOG20647 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001590016.1 Psort location: cytoplasmic, score: 23 YP_001590017.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_001590018.1 Psort location: mitochondrial, score: 23 YP_001590019.1 KEGG: cal:orf19.3526 1.8e-54 ITR2; myo-inositol transporter K08140; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001590020.1 COG: COG3091 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001590021.1 KEGG: sec:SC3033 4.3e-131 endA; DNA-specific endonuclease I K01150; COG: COG2356 Endonuclease I; Psort location: cytoplasmic, score: 23 YP_001590022.1 Psort location: endoplasmic reticulum, score: 9 YP_001590023.2 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_001590024.1 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione YP_001590025.1 COG: COG1678 Putative transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001590026.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function YP_001590027.1 COG: COG1414 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001590028.1 KEGG: pen:PSEEN2333 7.7e-26 xcpR-2; type II secretion pathway protein E K01509; COG: COG2805 Tfp pilus assembly protein, pilus retraction ATPase PilT; Psort location: cytoplasmic, score: 23 YP_001590029.1 KEGG: eci:UTI89_C3340 4.4e-106 yggS; hypothetical protein; COG: COG0325 Predicted enzyme with a TIM-barrel fold; Psort location: cytoplasmic, score: 23 YP_001590030.1 COG: COG0762 Predicted integral membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001590031.1 COG: COG1872 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001590032.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine YP_001590033.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_001590034.1 COG: NOG06290 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001590035.1 catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis YP_001590036.1 Psort location: cytoplasmic, score: 23 YP_001590037.1 COG: NOG06291 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001590038.1 COG: COG3171 Uncharacterized protein conserved in bacteria; Psort location: mitochondrial, score: 23 YP_001590039.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine YP_001590040.1 KEGG: stm:STM3110 6.3e-194 mutY; adenine DNA glycosylase K03575; COG: COG1194 A/G-specific DNA glycosylase; Psort location: cytoplasmic, score: 23 YP_001590041.1 KEGG: dps:DP2952 0.0096 probable fumarate hydratase class I, anaerobic K01676; COG: COG2924 Fe-S cluster protector protein; Psort location: cytoplasmic, score: 23 YP_001590042.1 Psort location: mitochondrial, score: 23 YP_001590043.1 Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues YP_001590044.1 Psort location: cytoplasmic, score: 23 YP_001590045.1 KEGG: eci:UTI89_C3355 3.2e-206 nupG; transport of nucleosides, permease protein K03289; COG: NOG06211 non supervised orthologous group; Psort location: plasma membrane, score: 23 YP_001590046.1 KEGG: sec:SC3055 0. speC; orniTHIne decarboxylase isozyme K01581; COG: COG1982 Arginine/lysine/orniTHIne decarboxylases; Psort location: cytoplasmic, score: 23 YP_001590047.1 Psort location: mitochondrial, score: 23 YP_001590048.1 Psort location: cytoplasmic, score: 23 YP_001590049.1 COG: COG1811 Uncharacterized membrane protein, possible Na+ channel or pump; Psort location: plasma membrane, score: 23 YP_001590050.1 KEGG: ret:RHE_CH00346 2.6e-37 putative biphenyl-2,3-diol 1,2-dioxygenase protein K00462; COG: COG0346 LactoylglutaTHIone lyase and related lyases; Psort location: cytoplasmic, score: 23 YP_001590051.1 KEGG: azo:azo3544 2.7e-74 probable 4-hydroxybutyrate coenzyme A transferase K01041; COG: COG0427 Acetyl-CoA hydrolase; Psort location: cytoplasmic, score: 23 YP_001590052.1 KEGG: nph:NP4248A 5.9e-24 fadB_1; enoyl-CoA hydratase II 1 K01692; COG: COG2030 Acyl dehydratase; Psort location: cytoplasmic, score: 23 YP_001590053.1 KEGG: stm:STM3120 1.6e-142 putative transcriptional regulator, LysR family K01644; COG: COG2301 Citrate lyase beta subunit; Psort location: cytoplasmic, score: 23 YP_001590054.1 KEGG: shn:Shewana3_3435 1.1e-20 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001590055.1 KEGG: stm:STM3122 0. putative arylsulfatase K01130; COG: COG3119 Arylsulfatase A and related enzymes; Psort location: extracellular, including cell wall, score: 9 YP_001590056.1 KEGG: syg:sync_2368 1.7e-20 arylsulfatase regulator; COG: COG0641 Arylsulfatase regulator (Fe-S oxidoreductase); Psort location: cytoplasmic, score: 23 YP_001590057.1 Psort location: mitochondrial, score: 23 YP_001590058.1 Psort location: cytoplasmic, score: 23 YP_001590059.1 KEGG: eci:UTI89_C1417 3.3e-06 narL; NarL transcriptional dual regulator K07684; COG: COG2909 ATP-dependent transcriptional regulator; Psort location: nuclear, score: 23 YP_001590060.1 COG: NOG18538 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001590061.1 KEGG: eci:UTI89_C0120 6.3e-06 aroP; aromatic amino acid transport protein AroP K03293; COG: COG0531 Amino acid transporters; Psort location: plasma membrane, score: 23 YP_001590062.1 Psort location: nuclear, score: 23 YP_001590063.1 COG: COG3450 Predicted enzyme of the cupin superfamily; Psort location: cytoplasmic, score: 23 YP_001590064.1 KEGG: stt:t3050 7.0e-234 ordL; putative oxidoreductase; COG: COG0665 Glycine/D-amino acid oxidases (deaminating); Psort location: cytoplasmic, score: 23 YP_001590065.1 KEGG: sec:SC3069 5.4e-259 feaB; putative NAD-dependent aldehyde dehydrogenase K00146; COG: COG1012 NAD-dependent aldehyde dehydrogenases; Psort location: endoplasmic reticulum, score: 9 YP_001590066.1 Psort location: cytoplasmic, score: 23 YP_001590067.1 inhibitor of RssB activity in response to DNA damage; blocks degradation of stationary phase sigma factor RpoS YP_001590068.1 COG: COG3157 Hemolysin-coregulated protein (uncharacterized); Psort location: cytoplasmic, score: 23 YP_001590069.1 Psort location: cytoplasmic, score: 23 YP_001590070.1 Psort location: nuclear, score: 23 YP_001590071.1 KEGG: hpa:HPAG1_0312 3.9e-50 hypothetical protein K01463; COG: COG0726 Predicted xylanase/chitin deacetylase; Psort location: cytoplasmic, score: 23 YP_001590072.1 KEGG: rha:RHA1_ro03918 1.0e-14 probable formamidase K01455; COG: COG0388 Predicted amidohydrolase; Psort location: cytoplasmic, score: 23 YP_001590073.1 Psort location: cytoplasmic, score: 23 YP_001590074.1 Psort location: cytoplasmic, score: 23 YP_001590075.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001590076.1 Psort location: cytoplasmic, score: 23 YP_001590077.1 Psort location: cytoplasmic, score: 23 YP_001590078.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate YP_001590079.1 KEGG: stt:t3057 6.3e-265 uxuB; D-mannonate oxidoreductase K00040; COG: COG0246 Mannitol-1-phosphate/altronate dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001590080.1 catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism YP_001590081.1 Psort location: nuclear, score: 23 YP_001590082.1 Psort location: nuclear, score: 23 YP_001590083.1 COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: mitochondrial, score: 23 YP_001590084.1 catalyzes the formation of glutathionylspermidine from glutathione and spermidine; also catalyzes the reverse reaction YP_001590085.1 YghU; B2989; one of eight putative glutathione transferase proteins from E. coli YP_001590086.1 COG: COG0725 ABC-type molybdate transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001590087.1 COG: COG0614 ABC-type Fe3+-hydroxamate transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001590088.1 COG: COG0298 Hydrogenase maturation factor; Psort location: endoplasmic reticulum, score: 9 YP_001590089.1 plays a role in hydrogenase nickel cofactor insertion YP_001590090.1 COG: NOG08099 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001590091.1 protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC) YP_001590092.1 involved in hydrogen uptake YP_001590093.1 HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits YP_001590094.1 Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2 YP_001590095.1 involved in hydrogen uptake YP_001590096.1 Psort location: mitochondrial, score: 23 YP_001590097.1 COG: NOG11338 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001590098.1 KEGG: abo:ABO_1307 1.3e-05 sensor histidine kinase/respose regulator; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001590099.1 COG: COG2862 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001590100.1 Psort location: cytoplasmic, score: 23 YP_001590101.1 Psort location: cytoplasmic, score: 23 YP_001590102.1 COG: NOG27696 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001590103.1 COG: NOG30084 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001590104.1 KEGG: sec:SC3099 2.1e-154 yghA; putative oxidoreductase; COG: COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases); Psort location: cytoplasmic, score: 23 YP_001590105.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell YP_001590106.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell YP_001590107.1 COG: NOG18127 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001590108.1 catalyzes the formation of L-homocysteine from cystathionine YP_001590109.1 KEGG: lsl:LSL_1322 1.4e-08 alkaline phosphatase K01077; COG: COG0586 Uncharacterized membrane-associated protein; Psort location: endoplasmic reticulum, score: 9 YP_001590110.1 KEGG: bli:BL05281 5.0e-07 adaA; methylphosphotriester-DNA alkyltransferase and transcriptional regulator (AraC/XylS family) K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001590111.1 Psort location: nuclear, score: 23 YP_001590112.1 KEGG: stm:STM3164 4.1e-206 yqhD; putative alcohol dehydrogenase K08325; COG: COG1979 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family; Psort location: cytoplasmic, score: 23 YP_001590113.1 methylglyoxal reductase/#-keto ester reductase; catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; also catalyzes the reduction of methylglyoxal, ethyl-2-methylacetoacetate and ethyl-acetoacetate YP_001590114.1 Psort location: nuclear, score: 23 YP_001590115.1 KEGG: fnu:FN2030 1.8e-05 inorganic pyrophosphatase K01507; COG: COG0471 Di- and tricarboxylate transporters; Psort location: plasma membrane, score: 23 YP_001590116.1 Psort location: cytoplasmic, score: 23 YP_001590117.1 COG: COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases; Psort location: cytoplasmic, score: 23 YP_001590118.1 Psort location: cytoplasmic, score: 23 YP_001590119.1 Psort location: endoplasmic reticulum, score: 9 YP_001590120.1 KEGG: eci:UTI89_C3435 0. hypothetical protein; COG: COG1032 Fe-S oxidoreductase; Psort location: nuclear, score: 23 YP_001590121.1 Psort location: cytoplasmic, score: 23 YP_001590122.1 COG: COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001590123.1 COG: COG3090 TRAP-type C4-dicarboxylate transport system, small permease component; Psort location: endoplasmic reticulum, score: 9 YP_001590124.1 COG: COG1593 TRAP-type C4-dicarboxylate transport system, large permease component; Psort location: plasma membrane, score: 23 YP_001590125.1 KEGG: eci:UTI89_C3443 2.3e-244 sufI; FtsI suppressor K04753; COG: COG2132 Putative multicopper oxidases; Psort location: cytoplasmic, score: 23 YP_001590126.1 KEGG: sty:STY3350 1.1e-130 plsC; 1-acyl-glycerol-3-phosphate acyltransferase K00655; COG: COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase; Psort location: endoplasmic reticulum, score: 9 YP_001590127.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_001590128.1 KEGG: bcz:BCZK3497 4.2e-14 adaA; transcriptional regulator, AraC family K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001590129.1 COG: COG3111 Uncharacterized conserved protein; Psort location: extracellular, including cell wall, score: 9 YP_001590130.1 response regulator in two-component regulatory system with QseC; regulates FlhCD which is the master regulator for flagella and motility genes YP_001590131.1 KEGG: sec:SC3122 2.0e-236 ygiY; putative sensory histidine kinase in regulatory system K07645; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 9 YP_001590132.1 KEGG: eci:UTI89_C3455 3.1e-98 mdaB; modulator of drug activity B K03923; COG: COG2249 Putative NADPH-quinone reductase (modulator of drug activity B); Psort location: cytoplasmic, score: 23 YP_001590133.1 COG: COG1359 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001590134.1 Psort location: nuclear, score: 23 YP_001590135.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_001590136.1 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate YP_001590137.1 KEGG: eci:UTI89_C3466 6.2e-139 icc; icc protein K03651; COG: COG1409 Predicted phosphohydrolases; Psort location: cytoplasmic, score: 23 YP_001590138.1 COG: COG3151 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001590139.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose YP_001590140.1 trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell YP_001590141.1 Psort location: nuclear, score: 23 YP_001590142.1 COG: COG5463 Predicted integral membrane protein; Psort location: nuclear, score: 23 YP_001590143.1 KEGG: vvy:VV2267 4.4e-122 glutaTHIonylspermidine synthase K01917; COG: COG0754 GlutaTHIonylspermidine synthase; Psort location: cytoplasmic, score: 23 YP_001590144.1 seems to be involved in biofilm formation; in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine YP_001590145.1 Psort location: cytoplasmic, score: 23 YP_001590146.1 COG: COG0428 Predicted divalent heavy-metal cations transporter; Psort location: plasma membrane, score: 23 YP_001590147.1 Psort location: cytoplasmic, score: 23 YP_001590148.1 KEGG: eci:UTI89_C3473 7.2e-296 assT; arylsulfate sulfotransferase K01023; COG: NOG06306 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001590149.1 KEGG: bci:BCI_0257 6.5e-10 dsbA; THIol:disulfide interchange protein DsbA K01829; COG: COG0526 Thiol-disulfide isomerase and THIoredoxins; Psort location: extracellular, including cell wall, score: 9 YP_001590150.1 KEGG: cps:CPS_3513 1.1e-15 dsbB; disulfide bond formation protein B K03611; COG: COG1495 Disulfide bond formation protein DsbB; Psort location: endoplasmic reticulum, score: 9 YP_001590151.1 DHBP synthase; functions during riboflavin biosynthesis YP_001590152.1 COG: COG2960 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001590153.1 Involved in glycogen synthesis. May be involved in glycogen priming YP_001590154.1 Psort location: cytoplasmic, score: 23 YP_001590155.1 COG: NOG09074 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001590156.1 KEGG: nma:NMA0905 5.0e-11 iga; IgA1 protease K01347; COG: COG2268 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001590157.1 catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose YP_001590158.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme YP_001590159.1 KEGG: aha:AHA_3770 1.6e-37 adenylate cyclase K01768; COG: COG3025 Uncharacterized conserved protein; Psort location: cytoskeletal, score: 9 YP_001590160.1 KEGG: bce:BC5234 0.0038 N-acetylmuramoyl-L-alanine amidase K01446; COG: COG3103 SH3 domain protein; Psort location: extracellular, including cell wall, score: 23 YP_001590161.1 catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases YP_001590162.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell YP_001590163.1 catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin YP_001590164.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX YP_001590165.1 Psort location: mitochondrial, score: 23 YP_001590166.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_001590167.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA YP_001590168.1 synthesizes RNA primers at the replication forks YP_001590169.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria YP_001590170.1 KEGG: stm:STM3212 2.3e-86 mug; DNA glycosylase, G/U mismatch specific K03649; COG: COG3663 G:T/U mismatch-specific DNA glycosylase; Psort location: cytoplasmic, score: 23 YP_001590171.1 COG: COG2375 Siderophore-interacting protein; Psort location: cytoplasmic, score: 23 YP_001590172.1 KEGG: msu:MS2199 0.00016 slpA; fKBP-type peptidyl-prolyl cis-trans isomerases 2 K03775; COG: COG1695 Predicted transcriptional regulators; Psort location: nuclear, score: 23 YP_001590173.1 KEGG: abo:ABO_1307 1.1e-06 sensor histidine kinase/respose regulator; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001590174.1 Psort location: nuclear, score: 23 YP_001590175.1 KEGG: azo:azo3685 4.3e-13 putative hybrid sensor and regulator protein; COG: COG2202 FOG: PAS/PAC domain; Psort location: endoplasmic reticulum, score: 9 YP_001590176.1 Psort location: cytoplasmic, score: 23 YP_001590177.1 catalyzes the formation of 4-aminobutyraldehyde from putrescine and 2-oxoglutarate YP_001590178.1 Psort location: extracellular, including cell wall, score: 9 YP_001590179.1 KEGG: stm:STM3219 0. fadH; 2,4-dieonyl-CoA reductase K00219; COG: COG0446 Uncharacterized NAD(FAD)-dependent dehydrogenases; Psort location: endoplasmic reticulum, score: 9 YP_001590180.1 KEGG: stm:STM3220 3.3e-204 ygjO; putative ribosomal RNA small subunit methyltransferase D K00564; COG: COG2813 16S RNA G1207 methylase RsmC; Psort location: cytoplasmic, score: 23 YP_001590181.1 COG: COG1451 Predicted metal-dependent hydrolase; Psort location: cytoplasmic, score: 23 YP_001590182.1 COG: COG2949 Uncharacterized membrane protein; Psort location: golgi, score: 9 YP_001590183.1 KEGG: ecc:c3845 9.0e-147 ygjR; hypothetical oxidoreductase YgjR; COG: COG0673 Predicted dehydrogenases and related proteins; Psort location: cytoplasmic, score: 23 YP_001590184.1 Psort location: mitochondrial, score: 23 YP_001590185.1 Psort location: mitochondrial, score: 23 YP_001590186.1 COG: COG0861 Membrane protein TerC, possibly involved in tellurium resistance; Psort location: plasma membrane, score: 23 YP_001590187.1 involved in the import of serine and threonine coupled with the import of sodium YP_001590188.1 Psort location: cytoplasmic, score: 23 YP_001590189.1 KEGG: sab:SAB2386 1.6e-08 probable alkaline phosphatase K01077; COG: COG0586 Uncharacterized membrane-associated protein; Psort location: endoplasmic reticulum, score: 9 YP_001590190.1 COG: NOG09774 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001590191.1 KEGG: bli:BL03996 7.8e-05 atpF; ATP synthase (subunit b) K02109; COG: NOG17164 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001590192.1 KEGG: tma:TM1614 0.0035 ATP synthase F0, subunit b K02109; COG: COG4575 Uncharacterized conserved protein; Psort location: vesicles of secretory system, score: 23 YP_001590193.1 COG: COG5393 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001590194.1 COG: NOG11454 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001590195.1 Psort location: cytoplasmic, score: 23 YP_001590196.1 KEGG: lpn:lpg0671 0.00014 ndh; NADH dehydrogenase transmembrane protein K03885; COG: COG2259 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001590197.1 KEGG: eci:UTI89_C3540 1.8e-173 yqjG; putative transferase K07393; COG: COG0435 Predicted glutaTHIone S-transferase; Psort location: cytoplasmic, score: 23 YP_001590198.1 COG: COG3152 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001590199.1 COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001590200.1 COG: COG1741 Pirin-related protein; Psort location: cytoplasmic, score: 23 YP_001590201.1 COG: NOG18539 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001590202.1 COG: COG3681 Uncharacterized conserved protein; Psort location: extracellular, including cell wall, score: 9 YP_001590203.1 COG: COG0814 Amino acid permeases; Psort location: plasma membrane, score: 23 YP_001590204.1 KEGG: spt:SPA3109 6.7e-229 tdcG; L-serine dehydratase K01752; COG: COG1760 L-serine deaminase; Psort location: cytoplasmic, score: 23 YP_001590205.1 KEGG: stm:STM3241 0. tdcE; pyruvate formate-lyase 4/2-ketobutyrate formate-lyase K00656; COG: COG1882 Pyruvate-formate lyase; Psort location: cytoplasmic, score: 23 YP_001590206.1 catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism YP_001590207.1 involved in the import of threonine and serine in combination with the import of a proton YP_001590208.1 catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic YP_001590209.1 regulates the tdcABCDEFG operon which is involved in amino acid degradation YP_001590210.1 Psort location: cytoplasmic, score: 23 YP_001590211.1 Psort location: nuclear, score: 23 YP_001590212.1 Psort location: nuclear, score: 23 YP_001590213.1 KEGG: stm:STM3247 4.6e-198 garK; glycerate kinase K00865; COG: COG1929 Glycerate kinase; Psort location: cytoplasmic, score: 23 YP_001590214.1 catalyzes the reduction of tartronate semialdehyde to glycerate YP_001590215.1 cleaves 5-dehydro-4-deoxy-glucarate and 2-dehydro-3-deoxy-D-glucarate YP_001590216.1 Psort location: cytoplasmic, score: 23 YP_001590217.1 Psort location: cytoplasmic, score: 23 YP_001590218.1 Psort location: cytoplasmic, score: 23 YP_001590219.1 KEGG: stm:STM3250 1.6e-282 garD; galactarate dehydrogenase K01708; COG: COG2721 Altronate dehydratase; Psort location: cytoplasmic, score: 23 YP_001590220.1 KEGG: eci:UTI89_C3698 9.3e-97 hypothetical protein K00847; COG: COG0524 Sugar kinases, ribokinase family; Psort location: cytoplasmic, score: 23 YP_001590221.1 COG: COG1349 Transcriptional regulators of sugar metabolism; Psort location: cytoplasmic, score: 23 YP_001590222.1 Psort location: cytoplasmic, score: 23 YP_001590223.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway YP_001590224.1 KEGG: stm:STM3254 7.2e-161 putative fructose-1-phosphate kinase K00882; COG: COG1105 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB); Psort location: cytoplasmic, score: 23 YP_001590225.1 KEGG: stm:STM3255 9.0e-250 putative phosphotransferase system fructose-specific component IIBC K02769:K02770; COG: COG1299 Phosphotransferase system, fructose-specific IIC component; Psort location: plasma membrane, score: 23 YP_001590226.1 KEGG: stm:STM3256 9.1e-138 PTS system, fructose-specific IIA component / phosphocarrier protein HPr K02768:K02784; COG: COG4668 Mannitol/fructose-specific phosphotransferase system, IIA domain; Psort location: cytoplasmic, score: 23 YP_001590227.1 KEGG: spt:SPA3126 2.0e-227 gatZ; putative tagatose 6-phosphate kinase 1 K00917; COG: COG4573 Predicted tagatose 6-phosphate kinase; Psort location: cytoplasmic, score: 23 YP_001590228.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_001590229.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_001590230.1 KEGG: eci:UTI89_C2365 7.2e-209 gatC; PTS system, galactitol-specific IIC component K02775; COG: COG3775 Phosphotransferase system, galactitol-specific IIC component; Psort location: plasma membrane, score: 23 YP_001590231.1 Zn-dependent; NAD(P)-binding; catalyzes the formation of tagatose-6-phosphate from galactitol-1-phosphate YP_001590232.1 COG: COG1349 Transcriptional regulators of sugar metabolism; Psort location: cytoplasmic, score: 23 YP_001590233.1 Psort location: cytoplasmic, score: 23 YP_001590234.1 KEGG: eci:UTI89_C3573 7.3e-145 yraL; hypothetical protein; COG: COG0313 Predicted methyltransferases; Psort location: cytoplasmic, score: 23 YP_001590235.1 KEGG: bpe:BP0475 0.0045 rne, ams, hmp1; ribonuclease E K08300; COG: COG3107 Putative lipoprotein; Psort location: nuclear, score: 23 YP_001590236.1 KEGG: eci:UTI89_C3574 7.5e-40 yraN; hypothetical protein YraN K07460; COG: COG0792 Predicted endonuclease distantly related to archaeal Holliday junction resolvase; Psort location: cytoplasmic, score: 23 YP_001590237.1 Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein YP_001590238.1 COG: COG2823 Predicted periplasmic or secreted lipoprotein; Psort location: extracellular, including cell wall, score: 9 YP_001590239.1 KEGG: ccr:CC3604 2.8e-11 NADH-ubiquinone oxidoreductase 39 kDa subunit precursor, putative K00329:K00356; COG: COG0702 Predicted nucleoside-diphosphate-sugar epimerases; Psort location: mitochondrial, score: 23 YP_001590240.1 KEGG: spt:SPA3138 2.0e-87 yhbO; hypothetical protein K05520; COG: COG0693 Putative intracellular protease/amidase; Psort location: cytoplasmic, score: 23 YP_001590241.1 COG: COG3787 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001590242.1 KEGG: mca:MCA0838 0.0077 type I restriction-modification system, R subunit K01153; COG: COG2827 Predicted endonuclease containing a URI domain; Psort location: cytoplasmic, score: 23 YP_001590243.1 KEGG: sec:SC3213 1.8e-86 yhbS; putative ABC superfamily (membrane) transport protein K03824; COG: COG3153 Predicted acetyltransferase; Psort location: cytoplasmic, score: 23 YP_001590244.1 COG: COG3154 Putative lipid carrier protein; Psort location: cytoplasmic, score: 23 YP_001590245.1 KEGG: stm:STM3274 1.1e-178 yhbU; putative protease K08303; COG: COG0826 Collagenase and related proteases; Psort location: cytoplasmic, score: 23 YP_001590246.1 KEGG: eci:UTI89_C3586 1.9e-146 yhbV; hypothetical protein YhbV K01423; COG: COG0826 Collagenase and related proteases; Psort location: cytoplasmic, score: 23 YP_001590247.1 KEGG: eci:UTI89_C3587 3.8e-171 yhbW; hypothetical protein K00494; COG: COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases; Psort location: cytoplasmic, score: 23 YP_001590248.1 COG: COG3034 Uncharacterized protein conserved in bacteria; Psort location: mitochondrial, score: 23 YP_001590249.1 Psort location: cytoplasmic, score: 23 YP_001590250.1 tryptophan transporter of high affinity YP_001590251.1 participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division YP_001590252.1 lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing YP_001590253.1 KEGG: sec:SC3223 0. pnp; polynucleotide phosphorylase, member of mRNA degradosome K00962; COG: COG1185 Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase); Psort location: cytoplasmic, score: 23 YP_001590254.1 COG: COG0184 Ribosomal protein S15P/S13E; Psort location: cytoplasmic, score: 23 YP_001590255.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs YP_001590256.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_001590257.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_001590258.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_001590259.2 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins YP_001590260.1 catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis YP_001590261.1 Psort location: extracellular, including cell wall, score: 9 YP_001590262.1 COG: COG1943 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001590263.1 Psort location: cytoplasmic, score: 23 YP_001590264.1 COG: COG1314 Preprotein translocase subunit SecG; Psort location: endoplasmic reticulum, score: 9 YP_001590265.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_001590266.1 catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate YP_001590267.1 Psort location: nuclear, score: 23 YP_001590268.1 inner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins YP_001590269.1 Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit YP_001590270.1 RNA binding protein found associated to pre-50S subunit of the ribosome; putative role in ribosome assembly; necessary for optimal growth but not cell viability YP_001590271.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_001590272.1 Psort location: cytoplasmic, score: 23 YP_001590273.1 penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains YP_001590274.1 Psort location: nuclear, score: 23 YP_001590275.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_001590276.1 COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: plasma membrane, score: 23 YP_001590277.1 involved in the peptidyltransferase reaction during translation YP_001590278.1 KEGG: mpa:MAP0263c 0.0082 NADPH quinone oxidoreductase, putative K00344; COG: COG0261 Ribosomal protein L21; Psort location: cytoplasmic, score: 23 YP_001590279.1 KEGG: sec:SC3243 8.9e-195 ispB; octaprenyl diphosphate synthase K02523; COG: COG0142 Geranylgeranyl pyrophosphate synthase; Psort location: extracellular, including cell wall, score: 9 YP_001590280.1 activator of maltose metabolism genes YP_001590281.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_001590282.1 COG: COG5007 Predicted transcriptional regulator, BolA superfamily; Psort location: cytoplasmic, score: 23 YP_001590283.1 Psort location: mitochondrial, score: 23 YP_001590284.1 COG: COG3113 Predicted NTP binding protein (contains STAS domain); Psort location: cytoplasmic, score: 23 YP_001590285.1 COG: COG2854 ABC-type transport system involved in resistance to organic solvents, auxiliary component; Psort location: extracellular, including cell wall, score: 9 YP_001590286.1 COG: COG1463 ABC-type transport system involved in resistance to organic solvents, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001590287.1 COG: COG0767 ABC-type transport system involved in resistance to organic solvents, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001590288.1 ATP-binding subunit of a putative ABC toluene efflux transporter YP_001590289.1 YrbG; inner membrane protein involved in cell envelope integrity; putative sodium ion/calcium ion exchanger; in E. coli it is non essential for cell viability; member of the YRBG family of cation/Ca2+ exchangers YP_001590290.1 KEGG: spt:SPA3182 7.1e-170 yrbH; putative isomerase K06041; COG: COG0794 Predicted sugar phosphate isomerase involved in capsule formation; Psort location: cytoplasmic, score: 23 YP_001590291.1 forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis YP_001590292.1 COG: COG3117 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001590293.1 LptA; periplasmic binding protein part of a putative ABC superfamily of uptake transporters; interacts with LptB protein, the ATP binding component of the uptake system YP_001590294.1 KEGG: pen:PSEEN1094 1.6e-83 ABC transporter, ATP-binding protein; COG: COG1137 ABC-type (unclassified) transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001590295.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen YP_001590296.1 YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing YP_001590297.1 KEGG: stm:STM3322 3.5e-81 ptsN; sugar specific PTS family, enzyme IIA, also regulates N metabolism K02806; COG: COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type); Psort location: cytoplasmic, score: 23 YP_001590298.1 KEGG: reh:H16_A0381 1.1e-59 predicted P-loop-containing kinase K01009; COG: COG1660 Predicted P-loop-containing kinase; Psort location: cytoplasmic, score: 23 YP_001590299.1 KEGG: aha:AHA_3919 3.5e-26 multiphosphoryl transfer protein (MTP) K00924; COG: COG1925 Phosphotransferase system, HPr-related proteins; Psort location: cytoplasmic, score: 23 YP_001590300.1 COG: NOG06212 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001590301.1 glycosyltransferase; polymerizes glycan strands in the peptidoglycan YP_001590302.1 KEGG: gvi:glr2813 4.0e-06 probable protease K05520; COG: COG3155 Uncharacterized protein involved in an early stage of isoprenoid biosynthesis; Psort location: extracellular, including cell wall, score: 9 YP_001590303.1 sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA YP_001590304.1 KEGG: eci:UTI89_C3647 7.4e-152 yhcC; hypothetical protein; COG: COG1242 Predicted Fe-S oxidoreductase; Psort location: cytoplasmic, score: 23 YP_001590305.1 Psort location: cytoplasmic, score: 23 YP_001590306.1 Psort location: mitochondrial, score: 23 YP_001590307.1 Psort location: cytoplasmic, score: 23 YP_001590308.1 Psort location: mitochondrial, score: 23 YP_001590309.1 catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate YP_001590310.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate YP_001590311.1 COG: COG4804 Uncharacterized conserved protein; Psort location: cytoskeletal, score: 9 YP_001590312.1 Psort location: cytoplasmic, score: 23 YP_001590313.1 KEGG: pae:PA2649 0.0035 nuoN; NADH dehydrogenase I chain N K00343; COG: COG1457 Purine-cytosine permease and related proteins; Psort location: plasma membrane, score: 23 YP_001590314.1 Catalyzes the deamination of cytosine to uracil and ammonia YP_001590315.1 COG: COG2731 Beta-galactosidase, beta subunit; Psort location: cytoplasmic, score: 23 YP_001590316.1 catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein YP_001590317.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate YP_001590318.1 KEGG: cal:orf19.6141 5.3e-05 HXT1; high-affinity hexose (glucose) transporter K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001590319.1 catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid YP_001590320.1 Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization YP_001590321.1 COG: COG2969 Stringent starvation protein B; Psort location: cytoplasmic, score: 23 YP_001590322.1 transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation YP_001590323.1 Psort location: nuclear, score: 23 YP_001590324.1 Psort location: cytoplasmic, score: 23 YP_001590325.1 forms a direct contact with the tRNA during translation YP_001590326.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_001590327.1 KEGG: reh:H16_A2322 7.0e-76 ATPase K01529; COG: COG1485 Predicted ATPase; Psort location: cytoplasmic, score: 23 YP_001590328.1 KEGG: eco:b3233 6.6e-64 yhcB; hypothetical protein K00424; COG: COG3105 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001590329.1 KEGG: spt:SPA3215 6.5e-231 degQ; serine protease K04772; COG: COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain; Psort location: extracellular, including cell wall, score: 9 YP_001590330.1 Psort location: mitochondrial, score: 23 YP_001590331.1 KEGG: sec:SC3287 6.7e-174 degS; periplasmic serine endoprotease K04691; COG: COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain; Psort location: cytoplasmic, score: 23 YP_001590332.1 KEGG: sec:SC0057 6.0e-23 citG2; putative modifier of citrate lyase protein K05966; COG: COG1767 Triphosphoribosyl-dephospho-CoA synthetase; Psort location: cytoplasmic, score: 23 YP_001590333.1 KEGG: sec:SC0048 3.4e-218 oadB; putative oxalacetate decarboxylase, subunit beta K01572; COG: COG1883 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit; Psort location: plasma membrane, score: 23 YP_001590334.1 catalyzes the formation of pyruvate from oxaloacetate YP_001590335.1 catalyzes the decarboxylation of oxaloacetate to form pyruvate and carbon dioxide YP_001590336.1 Involved in the tartrate degradation pathway YP_001590337.1 Involved in the tartrate degradation pathway YP_001590338.1 KEGG: ecj:JW3469 2.3e-13 arsB; arsenite/antimonite transporter K03893; COG: COG0471 Di- and tricarboxylate transporters; Psort location: plasma membrane, score: 23 YP_001590339.1 KEGG: msm:MSMEG_3400 6.2e-09 glutamyl-tRNA(Gln) amidotransferase subunit A K01957; COG: COG1802 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001590340.1 KEGG: msm:MSMEG_3400 0.00022 glutamyl-tRNA(Gln) amidotransferase subunit A K01957; COG: COG1802 Transcriptional regulators; Psort location: mitochondrial, score: 23 YP_001590341.1 oxidizes malate to oxaloacetate YP_001590342.1 Psort location: cytoplasmic, score: 23 YP_001590343.1 Psort location: cytoplasmic, score: 23 YP_001590344.1 COG: COG1438 Arginine repressor; Psort location: cytoplasmic, score: 23 YP_001590345.1 COG: NOG12178 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001590346.1 COG: NOG30709 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001590347.1 COG: COG2732 Barstar, RNAse (barnase) inhibitor; Psort location: cytoplasmic, score: 23 YP_001590348.1 with AaeA forms an efflux pump whose substrates are p-hydroxybenzoic acid 6-hydroxy-2-naphthoic and 2-hydroxycinnamate YP_001590349.1 with AaeB forms an efflux pump whose substrates are p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic and 2-hydroxycinnamate YP_001590350.1 membrane protein AaeX; the gene is a member of the aaeXAB operon YP_001590351.1 KEGG: shn:Shewana3_3435 4.3e-09 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001590352.1 responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA YP_001590353.1 COG: COG3164 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001590354.1 involved in the processing of the 5'end of 16S rRNA YP_001590355.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell YP_001590356.1 part of cell wall structural complex MreBCD; transmembrane component YP_001590357.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall YP_001590358.1 functions in MreBCD complex in some organisms YP_001590359.1 Psort location: cytoplasmic, score: 23 YP_001590360.1 regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules YP_001590361.1 KEGG: eci:UTI89_C3684 2.3e-155 yhdH; protein YhdH K00001; COG: COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases; Psort location: endoplasmic reticulum, score: 9 YP_001590362.1 in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ YP_001590363.1 in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme YP_001590364.1 Psort location: nuclear, score: 23 YP_001590365.1 Psort location: mitochondrial, score: 23 YP_001590366.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_001590367.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_001590368.1 COG: COG3924 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001590369.1 mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase YP_001590370.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype YP_001590371.1 Psort location: nuclear, score: 23 YP_001590372.1 Psort location: mitochondrial, score: 23 YP_001590373.1 Psort location: mitochondrial, score: 23 YP_001590374.1 KEGG: sec:SC3322 2.6e-163 yhdG, nifR3; putative TIM-barrel enzyme, possibly dehydrogenase K05540; COG: COG0042 tRNA-dihydrouridine synthase; Psort location: cytoplasmic, score: 23 YP_001590375.1 Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription YP_001590376.1 KEGG: sty:STY3566 1.2e-158 yhdJ; putative adenine-specific DNA-modification methylase K07319; COG: COG0863 DNA modification methylase; Psort location: nuclear, score: 23 YP_001590377.1 COG: NOG13902 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001590378.1 KEGG: shn:Shewana3_3829 2.9e-98 diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) K01745; COG: COG2199 FOG: GGDEF domain; Psort location: plasma membrane, score: 23 YP_001590379.1 COG: COG1309 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001590380.1 Psort location: cytoplasmic, score: 23 YP_001590381.1 Psort location: nuclear, score: 23 YP_001590382.1 Psort location: nuclear, score: 23 YP_001590383.1 COG: COG0845 Membrane-fusion protein; Psort location: nuclear, score: 23 YP_001590384.1 KEGG: eci:UTI89_C2351 1.0e-106 yegO; hypothetical protein YegO K07789; COG: COG0841 Cation/multidrug efflux pump; Psort location: plasma membrane, score: 23 YP_001590385.1 Psort location: endoplasmic reticulum, score: 9 YP_001590386.1 COG: NOG14133 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001590387.1 Psort location: mitochondrial, score: 23 YP_001590388.1 Psort location: nuclear, score: 23 YP_001590389.1 Psort location: cytoplasmic, score: 23 YP_001590390.1 KEGG: eci:UTI89_C3724 1.8e-84 yrdA; protein YrdA K00680; COG: COG0663 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily; Psort location: cytoplasmic, score: 23 YP_001590391.1 COG: NOG13911 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001590392.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate YP_001590393.1 RimN; YrdC; required for maturation of 16s RNA; binds preferentially double stranded RNA YP_001590394.1 KEGG: cvi:CV4269 1.8e-42 topA; DNA topoisomerase K03168; COG: COG0551 Zn-finger domain associated with topoisomerase type I; Psort location: nuclear, score: 23 YP_001590395.1 COG: COG2922 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001590396.1 COG: COG0758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake; Psort location: cytoplasmic, score: 23 YP_001590397.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_001590398.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth YP_001590399.1 catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA; SAM-dependent methyltransferase YP_001590400.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain YP_001590401.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock YP_001590402.1 mediates expression of the zinc export protein ZntA in response to high levels of zinc; member of MerR family of transcriptional regulators YP_001590403.1 COG: NOG18395 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001590404.1 is a component of the macrolide binding site in the peptidyl transferase center YP_001590405.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_001590406.2 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_001590407.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_001590409.2 COG: COG0099 Ribosomal protein S13; Psort location: cytoplasmic, score: 23 YP_001590411.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_001590412.1 late assembly protein YP_001590413.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_001590414.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_001590415.1 binds 5S rRNA along with protein L5 and L25 YP_001590416.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_001590417.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_001590418.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif YP_001590419.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_001590420.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_001590421.2 COG: COG0093 Ribosomal protein L14; Psort location: cytoplasmic, score: 23 YP_001590422.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_001590423.1 one of the stabilizing components for the large ribosomal subunit YP_001590424.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_001590425.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_001590426.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_001590427.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_001590428.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_001590429.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_001590430.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_001590431.2 COG: COG0087 Ribosomal protein L3; Psort location: cytoplasmic, score: 23 YP_001590432.1 Psort location: cytoplasmic, score: 23 YP_001590433.1 COG: COG0051 Ribosomal protein S10; Psort location: cytoplasmic, score: 23 YP_001590434.1 Psort location: cytoplasmic, score: 23 YP_001590435.1 KEGG: stm:STM3442 2.6e-85 hopD; leader peptidase HopD K02506; COG: COG1989 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases; Psort location: endoplasmic reticulum, score: 9 YP_001590436.1 iron storage protein YP_001590437.1 KEGG: sma:SAV5661 0.0041 nirB; putative nitrite reductase large subunit K00362; COG: COG2906 Bacterioferritin-associated ferredoxin; Psort location: nuclear, score: 23 YP_001590438.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_001590439.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_001590440.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_001590441.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs YP_001590442.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs YP_001590443.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs YP_001590444.1 COG: COG2964 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001590445.1 rotamase YP_001590446.1 COG: COG2900 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001590447.1 rotamase YP_001590448.1 Psort location: endoplasmic reticulum, score: 9 YP_001590449.1 KEGG: sto:ST1472 0.0027 DNA-directed RNA polymerase subunit M K03057; COG: COG3529 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain; Psort location: cytoplasmic, score: 23 YP_001590450.1 involved in potassium efflux YP_001590451.1 required for KefB activity YP_001590452.1 Psort location: nuclear, score: 23 YP_001590453.1 KEGG: pen:PSEEN0163 2.1e-186 ABC transporter, ATP-binding protein; COG: COG0488 ATPase components of ABC transporters with duplicated ATPase domains; Psort location: nuclear, score: 23 YP_001590454.1 Psort location: mitochondrial, score: 23 YP_001590455.1 Psort location: cytoplasmic, score: 23 YP_001590456.1 COG: NOG16906 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001590457.1 Psort location: nuclear, score: 23 YP_001590458.1 COG: COG0429 Predicted hydrolase of the alpha/beta-hydrolase fold; Psort location: mitochondrial, score: 23 YP_001590459.1 COG: COG3089 Uncharacterized protein conserved in bacteria; Psort location: cytoskeletal, score: 9 YP_001590460.1 KEGG: spt:SPA3330 6.9e-156 prkB; phosphoribulokinase K00855; COG: COG3954 Phosphoribulokinase; Psort location: cytoplasmic, score: 23 YP_001590461.1 COG: COG1765 Predicted redox protein, regulator of disulfide bond formation; Psort location: cytoplasmic, score: 23 YP_001590462.1 complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons YP_001590463.1 KEGG: ssn:SSO_3489 0. yhfK; hypothetical protein K01823; COG: COG1289 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001590464.1 DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate YP_001590465.1 Psort location: cytoplasmic, score: 23 YP_001590466.1 aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity YP_001590467.1 COG: COG2184 Protein involved in cell division; Psort location: cytoplasmic, score: 23 YP_001590468.1 COG: NOG18128 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001590469.1 KEGG: spt:SPA3338 1.0e-97 ppiA; peptidyl-prolyl cis-trans isomerase K03767; COG: COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family; Psort location: extracellular, including cell wall, score: 9 YP_001590470.1 Psort location: nuclear, score: 23 YP_001590471.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001590472.1 Psort location: mitochondrial, score: 23 YP_001590473.1 Psort location: cytoplasmic, score: 23 YP_001590474.1 KEGG: stm:STM3474 0. nirB; nitrite reductase, large subunit K00362; COG: COG1251 NAD(P)H-nitrite reductase; Psort location: cytoplasmic, score: 23 YP_001590475.1 involved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations YP_001590476.1 Psort location: nuclear, score: 23 YP_001590477.1 member of the FNT family of formate and nitrite transporters YP_001590478.1 multifunction enzyme consisting of uroporphyrin-III C-methyltransferase, precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase; catalyzes the methylation of uroporphyrinogen III to form precorrin-2, then catalyzes formation of sirohydrochlorin from precorrin-2 and finally catalyzed the formation of siroheme from sirohydrochlorin YP_001590479.1 KEGG: eci:UTI89_C1627 0. entS; EntS/YbdA MFS transporter; COG: COG5295 Autotransporter adhesin; Psort location: endoplasmic reticulum, score: 9 YP_001590480.1 COG: NOG13903 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001590481.1 Psort location: mitochondrial, score: 23 YP_001590482.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001590483.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate YP_001590484.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate YP_001590485.1 KEGG: stm:STM3484 2.2e-150 dam; DNA adenine methylase K06223; COG: COG0338 Site-specific DNA methylase; Psort location: cytoplasmic, score: 23 YP_001590486.1 Psort location: nuclear, score: 23 YP_001590487.1 KEGG: xcc:XCC2084 2.7e-09 rne; ribonuclease E K08300; COG: COG3266 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001590488.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis YP_001590489.1 Psort location: nuclear, score: 23 YP_001590490.1 outer membrane porin probably involved in uptake of extracellular double-stranded DNA; similar to outer membrane competence protein ComE from Haemophilus influenzae and outer membrane protein PilQ involved in type IV pilus production from Pseudomonas aeruginosa YP_001590491.1 COG: NOG12171 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001590492.1 COG: NOG13913 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001590493.1 COG: COG3166 Tfp pilus assembly protein PilN; Psort location: golgi, score: 9 YP_001590494.1 COG: NOG05966 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001590495.1 bifunctional murein transglycosylase/murein transpeptidase; penicillin-binding protein 1A; involved in the synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation; penicillin-insensitive transglycosylase catalyzes the formation of linear glycan strands and the penicillin-sensitive transpeptidase catalyzes the cross-linking of the peptide subunits YP_001590496.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose YP_001590497.1 Psort location: mitochondrial, score: 23 YP_001590498.1 COG: NOG06324 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001590499.1 KEGG: rso:RSc2880 5.8e-06 gph, RS00222; probable phosphoglycolate phosphatase protein K01091; COG: COG1011 Predicted hydrolase (HAD superfamily); Psort location: cytoplasmic, score: 23 YP_001590500.1 COG: COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog); Psort location: nuclear, score: 23 YP_001590501.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers YP_001590502.1 COG: NOG06297 non supervised orthologous group; Psort location: plasma membrane, score: 23 YP_001590503.1 Psort location: mitochondrial, score: 23 YP_001590504.1 Psort location: mitochondrial, score: 23 YP_001590505.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP YP_001590506.1 membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR YP_001590507.1 part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation YP_001590508.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_001590509.1 KEGG: bur:Bcep18194_A5099 1.4e-246 RNA binding S1; COG: COG2183 Transcriptional accessory protein; Psort location: cytoplasmic, score: 23 YP_001590510.1 Psort location: nuclear, score: 23 YP_001590511.1 COG: COG1918 Fe2+ transport system protein A; Psort location: cytoplasmic, score: 23 YP_001590512.1 cytoplasmic membrane ferrous uptake system permease; mutations disrupt the ability of Escherichia coli to take up ferrous iron; GTP-binding protein which requires GTP for efficient iron(II) uptake YP_001590513.1 COG: NOG13904 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001590514.1 Psort location: mitochondrial, score: 23 YP_001590515.1 COG: COG5464 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001590516.1 KEGG: eci:UTI89_C3913 1.7e-79 bioH; carboxylesterase involved in biosynthesis of pimeloyl-CoA/carboxylesterase K02170; COG: COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily); Psort location: cytoplasmic, score: 23 YP_001590517.1 Psort location: cytoplasmic, score: 23 YP_001590518.1 involved in high-affinity gluconate transport YP_001590519.1 cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source YP_001590520.1 Psort location: cytoplasmic, score: 23 YP_001590521.1 KEGG: eci:UTI89_C3106 6.9e-69 ygbN; hypothetical permease YgbN K03299; COG: COG2610 H+/gluconate symporter and related permeases; Psort location: plasma membrane, score: 23 YP_001590522.1 amylomaltase; acts to release glucose from maltodextrins YP_001590523.1 KEGG: sec:SC3446 0. malP; maltodextrin phosphorylase K00688; COG: COG0058 Glucan phosphorylase; Psort location: cytoplasmic, score: 23 YP_001590524.1 Psort location: cytoplasmic, score: 23 YP_001590525.1 Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides YP_001590526.1 represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism YP_001590527.1 Psort location: cytoplasmic, score: 23 YP_001590528.1 protease responsible for the cleavage between Ser and Asp residues of proteins in regions of high local hydrophilicity YP_001590529.1 belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine YP_001590530.1 in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane YP_001590531.1 COG: NOG37922 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001590532.1 KEGG: mst:Msp_0343 6.1e-22 pstS; PstS K02040; COG: COG0226 ABC-type phosphate transport system, periplasmic component; Psort location: endoplasmic reticulum, score: 23 YP_001590533.1 forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone YP_001590534.1 KEGG: ani:AN1180.2 0.0014 hypothetical protein K04428; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001590535.1 KEGG: stm:STM3531 0. putative dihydroxyacid dehydratase K01687; COG: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Psort location: cytoplasmic, score: 23 YP_001590536.1 KEGG: rpc:RPC_4382 5.7e-81 dihydrodipicolinate synthetase K01714; COG: COG0329 Dihydrodipicolinate synthase/N-acetylneuraminate lyase; Psort location: cytoplasmic, score: 23 YP_001590537.1 KEGG: ttj:TTHA1249 6.1e-09 acetyl-coenzyme A synthetase K01895; COG: COG1414 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001590538.1 KEGG: spt:SPA3385 0. glgP; glycogen phosphorylase K00688; COG: COG0058 Glucan phosphorylase; Psort location: cytoplasmic, score: 23 YP_001590539.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose YP_001590540.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate YP_001590541.1 catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen YP_001590542.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain YP_001590543.1 Psort location: cytoplasmic, score: 23 YP_001590544.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde YP_001590545.1 Psort location: nuclear, score: 23 YP_001590546.1 KEGG: eci:UTI89_C3106 1.4e-68 ygbN; hypothetical permease YgbN K03299; COG: COG2610 H+/gluconate symporter and related permeases; Psort location: plasma membrane, score: 23 YP_001590547.1 thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate YP_001590548.1 KEGG: efa:EF1922 3.8e-07 transcriptional regulator, LacI family/carbohydrate kinase, PfkB family protein K00852; COG: COG1609 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001590549.1 Psort location: cytoplasmic, score: 23 YP_001590550.1 KEGG: shn:Shewana3_3385 5.8e-13 hypoxanTHIne phosphoribosyltransferase K00760; COG: COG1741 Pirin-related protein; Psort location: cytoplasmic, score: 23 YP_001590551.1 KEGG: eco:b3440 1.5e-174 yhhX; predicted oxidoreductase with NAD(P)-binding Rossmann-fold domain; COG: COG0673 Predicted dehydrogenases and related proteins; Psort location: cytoplasmic, score: 23 YP_001590552.1 Psort location: nuclear, score: 23 YP_001590553.1 YhhY; regulated by the fur regulator; unknown function YP_001590554.1 Psort location: cytoplasmic, score: 23 YP_001590555.1 Psort location: cytoplasmic, score: 23 YP_001590556.1 KEGG: bth:BT2803 2.2e-47 ribokinase K00852; COG: COG0524 Sugar kinases, ribokinase family; Psort location: cytoplasmic, score: 23 YP_001590557.1 COG: COG5426 Uncharacterized membrane protein; Psort location: cytoplasmic, score: 23 YP_001590558.1 COG: COG3238 Uncharacterized protein conserved in bacteria; Psort location: plasma membrane, score: 23 YP_001590559.1 KEGG: eci:UTI89_C3877 1.9e-25 yhfV; phosphotriesterase-like protein; COG: COG1735 Predicted metal-dependent hydrolase with the TIM-barrel fold; Psort location: cytoplasmic, score: 23 YP_001590560.1 periplasmic enzyme; post-translationally processed into two subunits which are required for wild-type enzyme activity; cleaves the gammaglutamyl linkages of compounds such as glutathione and transfer the gammaglutamyl group to other amino acids and peptides YP_001590561.1 Psort location: cytoplasmic, score: 23 YP_001590562.1 KEGG: ddi:DDB0215408 1.6e-05 pkaC; AGC family protein kinase K04345; COG: NOG08680 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001590563.1 hydrolyzes diesters during transport at the inner face of the cytoplasmic membrane to glycerol-3-phosphate and alcohol; induced when cells are starved for inorganic phosphate YP_001590564.1 part of the UgpABCE glycerol-3-phosphate uptake system YP_001590565.1 with UgpABC is involved in uptake of glycerol-3-phosphate YP_001590566.1 with UgpEC is involved in the uptake of glycerol-3-phosphate YP_001590567.1 with UgpACE is involved in the uptake of glycerol-3-phosphate YP_001590568.1 COG: COG3654 Prophage maintenance system killer protein; Psort location: cytoplasmic, score: 23 YP_001590569.1 COG: COG2161 Antitoxin of toxin-antitoxin stability system; Psort location: cytoplasmic, score: 23 YP_001590570.1 with LivGHMJ and LivGHMK is part of the high-affinity branched-chain amino acid transport system; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine YP_001590571.1 Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine YP_001590572.1 Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine YP_001590573.1 LivHMGF is the membrane component of the LIV-I/LS branched-chain amino acid transporter YP_001590574.1 KEGG: aci:ACIAD3368 0.00046 mraW; S-adenosylmeTHIonine methyltransferase K03438; COG: COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component; Psort location: cytoplasmic, score: 23 YP_001590575.1 Psort location: extracellular, including cell wall, score: 9 YP_001590576.1 Psort location: cytoplasmic, score: 23 YP_001590577.1 KEGG: reh:H16_B0069 2.6e-05 acetyltransferase K00680; COG: NOG09777 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001590578.1 COG: NOG34100 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001590579.1 KEGG: ava:Ava_2791 0.0021 serine/threonine protein kinase K00903; COG: COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001590580.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters YP_001590581.1 Psort location: nuclear, score: 23 YP_001590582.1 putative ABC transporter, membrane protein YP_001590583.1 putative ATP-binding protein of an ATP-binding cassette transporter; when bound to FtsX, FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions YP_001590584.1 signal recognition protein receptor; functions in the targeting and insertion of membrane proteins YP_001590585.1 catalyzes the methylation of 16S rRNA at position G966 YP_001590586.1 COG: COG3776 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001590587.1 COG: NOG09778 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001590588.1 COG: COG3714 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001590589.1 P-type ATPase involved in the export of lead, cadmium, zinc and mercury YP_001590590.1 KEGG: vpa:VPA0675 5.9e-05 torS; sensor protein TorS K07647; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001590591.1 COG: COG0425 Predicted redox protein, regulator of disulfide bond formation; Psort location: cytoplasmic, score: 23 YP_001590592.1 COG: COG1738 Uncharacterized conserved protein; Psort location: endoplasmic reticulum, score: 9 YP_001590593.1 COG: NOG07879 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001590594.1 KEGG: aeh:Mlg_0022 0.0022 cytochrome c biogenesis protein, transmembrane region K04084; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001590595.1 Psort location: extracellular, including cell wall, score: 9 YP_001590596.1 KEGG: tbd:Tbd_2668 4.1e-12 phosphoribosylaminoimidazole-succinocarboxamide (SAICAR) synthetase K01923; COG: COG0628 Predicted permease; Psort location: endoplasmic reticulum, score: 9 YP_001590597.1 KEGG: sty:STY4228 3.3e-94 4'-phosphopantetheinyl transferase K06133; COG: COG2091 Phosphopantetheinyl transferase; Psort location: cytoplasmic, score: 23 YP_001590598.1 Inhibits transcription at high concentrations of nickel YP_001590599.1 KEGG: fal:FRAAL1796 8.9e-11 putative ABC transporter ATP-binding subunit; COG: COG0842 ABC-type multidrug transport system, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001590600.1 KEGG: rru:Rru_A1792 3.2e-80 ABC transporter component K01990; COG: COG1131 ABC-type multidrug transport system, ATPase component; Psort location: endoplasmic reticulum, score: 9 YP_001590601.1 KEGG: eci:UTI89_C0735 6.3e-06 tolA; membrane spanning protein TolA K03646; COG: COG0845 Membrane-fusion protein; Psort location: endoplasmic reticulum, score: 9 YP_001590602.1 Psort location: cytoplasmic, score: 23 YP_001590603.1 KEGG: gox:GOX1717 1.4e-06 putative oxidoreductase K00100; COG: COG2081 Predicted flavoproteins; Psort location: cytoplasmic, score: 23 YP_001590604.1 COG: COG0306 Phosphate/sulphate permeases; Psort location: plasma membrane, score: 23 YP_001590605.1 ppGpp-dependent, membrane associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress YP_001590606.1 COG: COG0589 Universal stress protein UspA and related nucleotide-binding proteins; Psort location: cytoplasmic, score: 23 YP_001590607.1 Psort location: mitochondrial, score: 23 YP_001590608.1 member of the POT family of peptide transporters; probable proton-dependent peptide transporter function YP_001590609.1 predicted SAM-dependent methyltransferase YP_001590610.1 KEGG: stm:STM3594 0. prlC; oligopeptidase A K01414; COG: COG0339 Zn-dependent oligopeptidases; Psort location: cytoplasmic, score: 23 YP_001590611.1 KEGG: cgl:NCgl1145 4.9e-24 cgl1192; serine protease; COG: COG1404 Subtilisin-like serine proteases; Psort location: cytoplasmic, score: 23 YP_001590612.1 Psort location: nuclear, score: 23 YP_001590613.1 COG: COG2961 Protein involved in catabolism of external DNA; Psort location: cytoplasmic, score: 23 YP_001590614.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense YP_001590615.1 KEGG: stm:STM3598 1.9e-178 putative L-asparaginase K01424; COG: COG0252 L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D; Psort location: extracellular, including cell wall, score: 9 YP_001590616.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB YP_001590617.1 KEGG: eco:b3374 3.0e-29 frlD, yhfQ; fructoselysine 6-kinase K00924; COG: COG0524 Sugar kinases, ribokinase family; Psort location: cytoplasmic, score: 23 YP_001590618.1 KEGG: lwe:lwe2018 3.4e-28 sugar isomerase domain protein; COG: COG2222 Predicted phosphosugar isomerases; Psort location: cytoplasmic, score: 23 YP_001590619.1 KEGG: reh:H16_A3019 6.0e-15 hutC; histidine utilization repressor; COG: COG2188 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001590620.1 cytoplasmic; catalyzes the hydrolysis of trehalose to glucose YP_001590621.1 COG: NOG26124 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001590622.1 Psort location: mitochondrial, score: 23 YP_001590623.1 KEGG: bam:Bamb_4258 5.0e-11 lysozyme K01185; COG: COG3772 Phage-related lysozyme (muraminidase); Psort location: mitochondrial, score: 23 YP_001590624.1 KEGG: ava:Ava_2028 5.8e-17 two component transcriptional regulator, LuxR family; COG: COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; Psort location: cytoplasmic, score: 23 YP_001590625.1 Psort location: cytoplasmic, score: 23 YP_001590626.1 Psort location: endoplasmic reticulum, score: 9 YP_001590627.1 KEGG: shn:Shewana3_3435 2.0e-11 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001590628.1 KEGG: eci:UTI89_C4054 3.3e-156 yhjD; hypothetical protein; COG: COG1295 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001590629.1 Psort location: cytoplasmic, score: 23 YP_001590630.1 Psort location: mitochondrial, score: 23 YP_001590631.1 KEGG: cal:orf19.2425 3.5e-05 highly conserved hypothetical protein K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001590632.1 COG: COG2982 Uncharacterized protein involved in outer membrane biogenesis; Psort location: endoplasmic reticulum, score: 9 YP_001590633.1 in Escherichia coli this protein is involved in flagellar function YP_001590634.1 Psort location: cytoplasmic, score: 23 YP_001590635.1 KEGG: spt:SPA3468 1.0e-161 kdgK; 2-dehydro-3-deoxygluconokinase K00874; COG: COG0524 Sugar kinases, ribokinase family; Psort location: cytoplasmic, score: 23 YP_001590636.1 KEGG: eci:UTI89_C4059 9.0e-234 yhjJ; protein YhjJ precursor K01412; COG: COG0612 Predicted Zn-dependent peptidases; Psort location: extracellular, including cell wall, score: 9 YP_001590637.1 Psort location: nuclear, score: 23 YP_001590638.1 involved in the transport of C4-dicarboxylates across the membrane YP_001590639.1 HmsP in Yersinia pestis plays a role in invasion of epithelial cells; the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation; inner membrane protein; similar to a putative phosphodiesterase protein from E. coli YP_001590640.1 Psort location: nuclear, score: 23 YP_001590641.1 cellulose is produced by the multicellular morphotypes of E. coli and Salmonella typhimurium; the cellulose biosynthesis genes bcsA, bcsB, bcsZ and bcsC are constitutively transcribed, however, cellulose synthesis is dependent on the expression of adrA YP_001590642.1 catalyzes the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans YP_001590643.1 binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP) YP_001590644.1 polymerizes uridine 5'-diphosphate glucose to cellulose; acts with BcsB, BcsZ and BcsC in cellulose biosynthesis YP_001590645.1 COG: COG1192 ATPases involved in chromosome partitioning; Psort location: extracellular, including cell wall, score: 9 YP_001590646.1 COG: NOG13865 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001590647.1 Psort location: cytoplasmic, score: 23 YP_001590648.1 KEGG: vfi:VFA0886 3.1e-27 zinc metalloprotease; COG: NOG14695 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001590649.1 COG: NOG15366 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001590650.1 COG: NOG05994 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001590651.1 COG: NOG18129 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001590652.1 Psort location: cytoplasmic, score: 23 YP_001590653.1 KEGG: saz:Sama_1242 8.4e-07 meTHIonine gamma-lyase K01761; COG: COG0626 CystaTHIonine beta-lyases/cystaTHIonine gamma-synthases; Psort location: cytoplasmic, score: 23 YP_001590654.1 COG: COG0814 Amino acid permeases; Psort location: plasma membrane, score: 23 YP_001590655.1 Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides YP_001590656.1 DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF YP_001590657.1 KEGG: bpm:BURPS1710b_A0449 5.3e-05 glycine betaine/L-proline ABC transporter, permease protein K02001; COG: COG1173 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001590658.1 transports peptides consisting of two or three amino acids YP_001590659.1 Psort location: mitochondrial, score: 23 YP_001590660.1 KEGG: shn:Shewana3_2650 7.9e-126 acetate kinase K00925; COG: COG0747 ABC-type dipeptide transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001590661.1 KEGG: bcz:BCZK0244 1.3e-12 guanine-hypoxanTHIne permease; xanTHIne/uracil permease family protein K06901; COG: COG2233 XanTHIne/uracil permeases; Psort location: plasma membrane, score: 23 YP_001590662.1 COG: NOG08023 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001590663.1 Psort location: nuclear, score: 23 YP_001590664.1 COG: COG1609 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001590665.1 catalyzes the addition of a phosphoethanolamine group to the outer Kdo residue of lipopolysaccharide YP_001590666.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001590667.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001590668.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: mitochondrial, score: 23 YP_001590669.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001590670.1 Psort location: cytoplasmic, score: 23 YP_001590671.1 COG: COG5571 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion; Psort location: mitochondrial, score: 23 YP_001590672.1 constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine YP_001590673.1 KEGG: sec:SC3575 3.7e-77 yiaC; putative acetyltransferase K03826; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: extracellular, including cell wall, score: 9 YP_001590674.1 KEGG: stm:STM3644 0. bisC; biotin sulfoxide reductase K08351; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: cytoplasmic, score: 23 YP_001590675.1 KEGG: bxe:Bxe_A4171 4.6e-05 putative cytochrome c oxidase K00403; COG: COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins; Psort location: extracellular, including cell wall, score: 9 YP_001590676.1 Psort location: mitochondrial, score: 23 YP_001590677.1 KEGG: spt:SPA3498 1.5e-169 yiaE; putative 2-hydroxyacid dehydrogenase K00090; COG: COG1052 Lactate dehydrogenase and related dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001590678.1 COG: NOG06217 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001590679.1 Psort location: cytoplasmic, score: 23 YP_001590680.1 COG: COG2944 Predicted transcriptional regulator; Psort location: nuclear, score: 23 YP_001590681.1 Psort location: cytoplasmic, score: 23 YP_001590682.1 COG: COG1278 Cold shock proteins; Psort location: cytoplasmic, score: 23 YP_001590683.1 COG: NOG09853 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001590684.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_001590685.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_001590686.1 Psort location: nuclear, score: 23 YP_001590687.1 COG: NOG10996 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001590688.1 Psort location: nuclear, score: 23 YP_001590689.1 KEGG: eci:UTI89_C1243 0.0016 ycfT; hypothetical protein K00680; COG: COG3274 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001590690.1 COG: COG4682 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001590691.1 Psort location: cytoplasmic, score: 23 YP_001590692.1 KEGG: stt:t3859 1.7e-264 xylB; xylulose kinase K00854; COG: COG1070 Sugar (pentulose and hexulose) kinases; Psort location: cytoplasmic, score: 23 YP_001590693.1 catalyzes the interconversion of D-xylose to D-xylulose YP_001590694.1 Psort location: cytoplasmic, score: 23 YP_001590695.1 KEGG: bcz:BCZK2914 6.2e-11 adaA; methylphosphotriester-DNA alkyltransferase K00567; COG: COG1609 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001590696.1 KEGG: lpl:lp_2645 0.00047 acm2; muramidase K01185; COG: COG2992 Uncharacterized FlgJ-related protein; Psort location: nuclear, score: 23 YP_001590697.1 Psort location: nuclear, score: 23 YP_001590698.1 Psort location: cytoskeletal, score: 9 YP_001590699.1 periplasmic enzyme that degrades maltodextrins that enter via the outer membrane porin LamB; hydrolyzes alpha-(1,4) glycosidic linkages; contains internal disulfide bonds YP_001590700.1 Psort location: cytoplasmic, score: 23 YP_001590701.1 transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis YP_001590702.1 KEGG: eci:UTI89_C4115 3.6e-63 ysaA, yiaI; putative electron transport protein YsaA K00122; COG: COG1142 Fe-S-cluster-containing hydrogenase components 2; Psort location: cytoplasmic, score: 23 YP_001590703.1 KEGG: tth:TTC0885 2.6e-08 acetyl-coenzyme A synthetase K01895; COG: COG1414 Transcriptional regulator; Psort location: nuclear, score: 23 YP_001590704.1 Psort location: vesicles of secretory system, score: 9 YP_001590705.1 NAD(P)H-dependent; catalyzes the reduction of 2,3-diketo-L-gulonate to 3-keto-L-gulonate YP_001590706.1 COG: COG2731 Beta-galactosidase, beta subunit; Psort location: cytoplasmic, score: 23 YP_001590707.1 COG: NOG11374 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001590708.1 membrane-spanning protein involved in uptake of 2,3-diketo-L-gulonate; part of the tri-partite ATP-independent periplasmic transport system (TRAP) YiaMNO YP_001590709.1 COG: COG1593 TRAP-type C4-dicarboxylate transport system, large permease component; Psort location: plasma membrane, score: 23 YP_001590710.1 COG: COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001590711.1 KEGG: stm:STM3674 5.0e-272 lyxK; L-xylulose kinase K00880; COG: COG1070 Sugar (pentulose and hexulose) kinases; Psort location: endoplasmic reticulum, score: 9 YP_001590712.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate YP_001590713.1 L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate YP_001590714.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source YP_001590715.1 Psort location: mitochondrial, score: 23 YP_001590716.1 KEGG: bce:BC3740 1.3e-10 ADA regulatory protein K00567; COG: COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain; Psort location: cytoplasmic, score: 23 YP_001590717.1 Psort location: cytoplasmic, score: 23 YP_001590718.1 COG: COG3533 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001590719.1 KEGG: stm:STM3680 2.4e-279 aldB; aldehyde dehydrogenase B K00138; COG: COG1012 NAD-dependent aldehyde dehydrogenases; Psort location: endoplasmic reticulum, score: 9 YP_001590720.1 KEGG: fnu:FN1474 1.0e-35 N-acetylmannosamine kinase K00885; COG: COG1940 Transcriptional regulator/sugar kinase; Psort location: cytoplasmic, score: 23 YP_001590721.1 KEGG: eci:UTI89_C4132 3.3e-284 selB; selenocysteine-specific elongation factor K03833; COG: COG3276 Selenocysteine-specific translation elongation factor; Psort location: cytoplasmic, score: 23 YP_001590722.1 catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis YP_001590723.1 KEGG: eci:UTI89_C4134 1.1e-91 yibF; putative S-transferase K00799; COG: COG0625 GlutaTHIone S-transferase; Psort location: cytoplasmic, score: 23 YP_001590724.1 KEGG: stm:STM3685 0. mtlA; PTS family, mannitol-specific enzyme IIABC components K02798:K02799:K02800; COG: COG4668 Mannitol/fructose-specific phosphotransferase system, IIA domain; Psort location: plasma membrane, score: 23 YP_001590725.1 KEGG: stm:STM3686 6.6e-199 mtlD; mannitol-1-phosphate dehydrogenase K00009; COG: COG0246 Mannitol-1-phosphate/altronate dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001590726.1 Acts as a repressor of the mtlAD operon YP_001590727.1 KEGG: eca:ECA2363 2.6e-05 DNA polymerase III, theta subunit K00961; COG: NOG18544 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001590728.1 Psort location: cytoplasmic, score: 23 YP_001590729.1 COG: NOG10267 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001590730.1 Psort location: cytoplasmic, score: 23 YP_001590731.1 COG: NOG09780 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001590732.1 COG: NOG09780 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001590733.1 KEGG: eci:UTI89_C4143 0. putative autotransport adhesin K01423; COG: COG5295 Autotransporter adhesin; Psort location: nuclear, score: 23 YP_001590734.1 COG: COG1620 L-lactate permease; Psort location: plasma membrane, score: 23 YP_001590735.1 represses the lctPRD operon YP_001590736.1 flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration YP_001590737.1 member of the SPOUT superfamily of RNA methyltransferases; no methyltransferase activity observed with certain tRNA substrates YP_001590738.1 KEGG: efa:EF1922 7.3e-06 transcriptional regulator, LacI family/carbohydrate kinase, PfkB family protein K00852; COG: COG1609 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001590739.1 Psort location: cytoplasmic, score: 23 YP_001590740.1 KEGG: stm:STM3697 1.7e-214 putative mandelate racemase / muconate lactonizing enzyme family K01781; COG: COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily; Psort location: cytoplasmic, score: 23 YP_001590741.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001590742.1 catalyzes the O-acetylation of serine YP_001590743.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_001590744.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA YP_001590745.1 KEGG: eci:UTI89_C4152 3.3e-37 grxC; glutaredoxin 3 K03676; COG: COG0695 Glutaredoxin and related proteins; Psort location: cytoplasmic, score: 23 YP_001590746.1 KEGG: pha:PSHAa0367 2.2e-26 rhodanese sulfur transferase K01010; COG: COG0607 Rhodanese-related sulfurtransferase; Psort location: cytoplasmic, score: 23 YP_001590747.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate YP_001590748.1 KEGG: cya:CYA_1627 7.9e-29 peptidase, M23B family; COG: COG4942 Membrane-bound metallopeptidase; Psort location: nuclear, score: 23 YP_001590749.1 COG: COG2861 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001590750.1 KEGG: stm:STM3707 6.9e-188 yibD; putative glycosyltransferase; COG: COG0463 Glycosyltransferases involved in cell wall biogenesis; Psort location: extracellular, including cell wall, score: 23 YP_001590751.1 converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism YP_001590752.1 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine YP_001590753.1 catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose YP_001590754.1 catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core YP_001590755.1 KEGG: sec:SC3635 1.1e-171 rfaC; heptosyl transferase I K02841; COG: COG0859 ADP-heptose:LPS heptosyltransferase; Psort location: cytoplasmic, score: 23 YP_001590756.1 KEGG: spt:SPA3565 2.3e-212 waaL; O-antigen ligase K02847; COG: COG3307 Lipid A core - O-antigen ligase and related enzymes; Psort location: plasma membrane, score: 23 YP_001590757.1 KEGG: sec:SC3637 1.3e-200 rfaK; putative hexose transferase, lipopolysaccharide core biosynthesis K03280; COG: COG0438 Glycosyltransferase; Psort location: cytoplasmic, score: 23 YP_001590758.1 COG: NOG06879 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001590759.1 KEGG: spt:SPA3568 6.4e-121 waaY; lipopolysaccharide core biosynthesis protein K02850; COG: NOG10262 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001590760.1 KEGG: stm:STM3717 4.8e-180 rfaJ, waaJ; UDP-D-glucose:(galactosyl)lipopolysaccharide alpha-1,2-glucosyltransferase K03279; COG: COG1442 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases; Psort location: cytoplasmic, score: 23 YP_001590761.1 KEGG: sec:SC3641 2.8e-182 rfaI; UDP-D-galactose:(glucosyl)lipopolysaccharide-alpha-1, 3-D-galactosyltransferase K03278; COG: COG1442 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases; Psort location: cytoplasmic, score: 23 YP_001590762.1 KEGG: sec:SC3642 6.1e-196 rfaB; UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase K02840; COG: COG0438 Glycosyltransferase; Psort location: cytoplasmic, score: 23 YP_001590763.1 COG: COG1442 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases; Psort location: cytoplasmic, score: 23 YP_001590764.1 KEGG: stm:STM3721 5.9e-143 rfaP, waaP; lipopolysaccharide core biosynthesis; phosphorylation of HepI K02848; COG: NOG06227 non supervised orthologous group; Psort location: cytoskeletal, score: 9 YP_001590765.1 KEGG: stm:STM3722 1.6e-202 rfaG, waaG; UDP-glucose:(heptosyl)lipopolysaccharide alpha-1,3-glucosyltransferase K02844; COG: COG0438 Glycosyltransferase; Psort location: mitochondrial, score: 23 YP_001590766.1 KEGG: stm:STM3723 6.8e-181 rfaQ, waaQ; lipopolysaccharide heptosyltransferase III K02849; COG: COG0859 ADP-heptose:LPS heptosyltransferase; Psort location: cytoplasmic, score: 23 YP_001590767.1 Psort location: nuclear, score: 23 YP_001590768.1 Psort location: extracellular, including cell wall, score: 9 YP_001590769.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A YP_001590770.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_001590771.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases YP_001590772.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_001590773.1 COG: COG0227 Ribosomal protein L28; Psort location: mitochondrial, score: 23 YP_001590774.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase YP_001590775.2 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine YP_001590776.1 catalyzes the formation of dUMP from dUTP YP_001590777.1 FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly YP_001590778.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_001590779.1 KEGG: sty:STY4060 7.7e-86 rph; RNase PH K00989; COG: COG0689 RNase PH; Psort location: cytoplasmic, score: 23 YP_001590780.1 Psort location: cytoplasmic, score: 23 YP_001590781.1 COG: COG1561 Uncharacterized stress-induced protein; Psort location: cytoplasmic, score: 23 YP_001590782.1 KEGG: shn:Shewana3_3435 0.0045 transcriptional regulator, LysR family K06022; COG: NOG25608 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001590783.1 KEGG: sus:Acid_6874 1.5e-41 beta-lactamase K01467; COG: COG0491 Zn-dependent hydrolases, including glyoxylases; Psort location: extracellular, including cell wall, score: 9 YP_001590784.1 COG: COG2860 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001590785.1 this ligase is similar to LigA but it lacks the C-terminal BRCT domain; catalyzes strand joining of nicked DNA in the presence of a divalent cation and NAD+ YP_001590786.1 Psort location: mitochondrial, score: 23 YP_001590787.1 Essential for recycling GMP and indirectly, cGMP YP_001590788.1 promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits YP_001590789.1 KEGG: spt:SPA3594 0. spoT; Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase; CG Site No. 156 K01139; COG: COG0317 Guanosine polyphosphate pyrophosphohydrolases/synthetases; Psort location: cytoplasmic, score: 23 YP_001590790.1 specifically modifies tRNA at position G18 YP_001590791.1 catalyzes branch migration in Holliday junction intermediates YP_001590792.1 KEGG: bxe:Bxe_A4149 0.0052 cytochrome bd ubiquinol oxidase, subunit II K00426; COG: COG0786 Na+/glutamate symporter; Psort location: plasma membrane, score: 23 YP_001590793.1 Psort location: cytoplasmic, score: 23 YP_001590794.1 KEGG: hpa:HPAG1_1114 0.0011 hypothetical protein K00760; COG: COG2233 XanTHIne/uracil permeases; Psort location: plasma membrane, score: 23 YP_001590795.1 COG: NOG06061 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001590796.1 Psort location: cytoplasmic, score: 23 YP_001590797.1 catalyzes the transfer of alpha-xylosyl residue from alpha-xyloside to xylose, glucose, mannose, fructose, maltose, isomaltose, nigerose, kojibiose, sucrose, and trehalose; shows higher activity against alpha-xylosyl fluoride, isoprimeverose (6-O-alpha-xylopyranosyl-glucopyranose), and alpha-xyloside in xyloglucan oligosaccharides YP_001590798.1 may be involved in the transport of galactosides-pentoses-hexuronides YP_001590799.1 Psort location: nuclear, score: 23 YP_001590800.1 COG: NOG29416 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001590801.1 Psort location: extracellular, including cell wall, score: 9 YP_001590802.1 Psort location: cytoplasmic, score: 23 YP_001590803.1 Psort location: extracellular, including cell wall, score: 9 YP_001590804.1 COG: NOG06321 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001590805.1 COG: COG3943 Virulence protein; Psort location: cytoplasmic, score: 23 YP_001590806.1 COG: COG2963 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001590807.1 Psort location: cytoplasmic, score: 23 YP_001590808.1 COG: COG2771 DNA-binding HTH domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001590809.1 Psort location: cytoplasmic, score: 23 YP_001590810.1 KEGG: eci:UTI89_C2514 3.5e-65 yfaL; hypothetical protein YfaL precursor K07279; COG: COG3468 Type V secretory pathway, adhesin AidA; Psort location: extracellular, including cell wall, score: 9 YP_001590811.1 COG: NOG14138 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001590812.1 COG: COG3710 DNA-binding winged-HTH domains; Psort location: endoplasmic reticulum, score: 9 YP_001590813.1 Psort location: nuclear, score: 23 YP_001590814.1 KEGG: psp:PSPPH_0909 4.2e-46 isochorismatase family protein K05993; COG: COG1335 Amidases related to nicotinamidase; Psort location: endoplasmic reticulum, score: 9 YP_001590815.1 Psort location: cytoplasmic, score: 23 YP_001590816.1 Psort location: mitochondrial, score: 23 YP_001590817.1 COG: NOG12157 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 23 YP_001590818.1 Psort location: nuclear, score: 23 YP_001590819.1 Psort location: cytoplasmic, score: 23 YP_001590820.1 KEGG: stm:STM3763 0. mgtB; Mg2+ transport protein K01531; COG: COG0474 Cation transport ATPase; Psort location: plasma membrane, score: 23 YP_001590821.1 Psort location: cytoplasmic, score: 23 YP_001590822.1 KEGG: mtu:Rv1811 9.6e-40 mgtC; possible Mg2+ transport P-type ATPase C MgtC K07507; COG: COG1285 Uncharacterized membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001590823.1 Psort location: nuclear, score: 23 YP_001590824.1 Psort location: nuclear, score: 23 YP_001590825.1 COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: plasma membrane, score: 23 YP_001590826.1 COG: COG5464 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001590827.1 COG: NOG14137 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001590828.1 KEGG: stm:STM3768 2.9e-189 putative selenocysteine synthase [L-seryl-tRNA(Ser) selenium transferase K01042; COG: COG1921 Selenocysteine synthase [seryl-tRNASer selenium transferase]; Psort location: cytoplasmic, score: 23 YP_001590829.1 KEGG: lsl:LSL_1949 6.4e-50 PTS system, mannose-specific IID component K00890; COG: COG3716 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID; Psort location: plasma membrane, score: 23 YP_001590830.1 KEGG: lsl:LSL_1950 2.3e-29 PTS system, mannose-specific IIC component K00890; COG: COG3715 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC; Psort location: endoplasmic reticulum, score: 9 YP_001590831.1 KEGG: spt:SPA3621 4.4e-83 putative PTS system protein K02794; COG: COG3444 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB; Psort location: cytoplasmic, score: 23 YP_001590832.1 KEGG: spt:SPA3622 2.0e-69 putative PTS system protein K02793; COG: COG2893 Phosphotransferase system, mannose/fructose-specific component IIA; Psort location: extracellular, including cell wall, score: 9 YP_001590833.1 Psort location: mitochondrial, score: 23 YP_001590834.1 KEGG: eci:UTI89_C1573 6.5e-21 pspF; psp operon transcriptional activator K03974; COG: COG3933 Transcriptional antiterminator; Psort location: cytoplasmic, score: 23 YP_001590835.1 COG: NOG12179 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001590836.1 Psort location: cytoplasmic, score: 23 YP_001590837.1 KEGG: sty:STY4009 8.9e-266 putative glycosyl hydrolase K05350; COG: COG2723 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase; Psort location: cytoplasmic, score: 23 YP_001590838.1 experimental results in Escherichia coli suggest that this gene encodes an inosine export protein; member of major facilitator superfamily; MFS YP_001590839.1 COG: COG4737 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001590840.1 COG: COG2944 Predicted transcriptional regulator; Psort location: nuclear, score: 23 YP_001590841.1 KEGG: aha:AHA_2348 1.0e-08 multiphosphoryl transfer protein (MTP) (phosphotransferase FPrprotein) (pseudo-HPr) K00924; COG: COG1925 Phosphotransferase system, HPr-related proteins; Psort location: mitochondrial, score: 23 YP_001590842.1 class II aldolase; catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis YP_001590843.1 KEGG: eci:UTI89_C4003 4.9e-171 putative xylulose kinase K00851; COG: COG1070 Sugar (pentulose and hexulose) kinases; Psort location: cytoplasmic, score: 23 YP_001590844.1 KEGG: eci:UTI89_C4002 1.6e-218 PTS system, galactitol-specific IIC component K02775; COG: COG3775 Phosphotransferase system, galactitol-specific IIC component; Psort location: plasma membrane, score: 23 YP_001590845.1 Psort location: cytoplasmic, score: 23 YP_001590846.1 KEGG: stt:t3735 6.1e-45 putative IIB component of PTS system K02774; COG: COG3414 Phosphotransferase system, galactitol-specific IIB component; Psort location: endoplasmic reticulum, score: 9 YP_001590847.1 KEGG: spt:SPA3634 2.2e-81 PTS system, galactitol-specific IIA component K02773; COG: COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type); Psort location: cytoplasmic, score: 23 YP_001590848.1 KEGG: reh:H16_A3019 2.0e-14 hutC; histidine utilization repressor; COG: COG2188 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001590849.1 Psort location: cytoplasmic, score: 23 YP_001590850.1 COG: NOG09018 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001590851.1 Psort location: cytoplasmic, score: 23 YP_001590852.1 cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate YP_001590853.1 membrane protein regulates uhpT expression YP_001590854.1 Member of the two-component regulatory system UhpB/UhpA involved in the regulation of the uptake of hexose ph YP_001590855.1 response regulator in two-component regulatory system wtih UhpB; phosphorylated UhpA is a positive activator uhpT, a hexose phosphates transporter YP_001590856.1 COG: NOG07851 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001590857.1 COG: COG0738 Fucose permease; Psort location: plasma membrane, score: 23 YP_001590858.1 KEGG: stm:STM3793 2.7e-161 putative sugar kinase K00852; COG: COG0524 Sugar kinases, ribokinase family; Psort location: cytoplasmic, score: 23 YP_001590859.1 Psort location: cytoplasmic, score: 23 YP_001590860.1 COG: COG1349 Transcriptional regulators of sugar metabolism; Psort location: cytoplasmic, score: 23 YP_001590861.1 with IlvB catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase small subunit YP_001590862.1 KEGG: spt:SPA3646 2.2e-301 ilvB; acetohydroxy acid synthase I, small subunit K01652; COG: COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Psort location: cytoplasmic, score: 23 YP_001590863.1 Psort location: cytoplasmic, score: 23 YP_001590864.1 Psort location: mitochondrial, score: 23 YP_001590865.1 Psort location: endoplasmic reticulum, score: 9 YP_001590866.1 COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: plasma membrane, score: 23 YP_001590867.1 Psort location: mitochondrial, score: 23 YP_001590868.1 Psort location: nuclear, score: 23 YP_001590869.1 multidrug efflux protein involved in adaptation to low energy shock YP_001590870.1 KEGG: bja:blr3367 3.7e-07 probable cellulase K01179; COG: NOG14136 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9; ORF located using Blastx YP_001590871.1 regulates the synthesis and expression of the dsdXA operon and dadA gene YP_001590872.1 Psort location: cytoplasmic, score: 23 YP_001590873.1 member of the Gnt family of gluconate transporters; not involved in gluconate transport; unknown function YP_001590874.1 catalyzes the formation of pyruvate from serine YP_001590875.1 COG: COG0641 Arylsulfatase regulator (Fe-S oxidoreductase); Psort location: nuclear, score: 23 YP_001590876.1 COG: NOG09782 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001590877.1 KEGG: cal:orf19.201 9.1e-06 CDC47; DNA helicase and DNA replication licensing factor K02210; COG: COG2149 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001590878.1 Psort location: nuclear, score: 23 YP_001590879.1 Psort location: cytoplasmic, score: 23 YP_001590880.1 Psort location: cytoplasmic, score: 23 YP_001590881.1 Psort location: nuclear, score: 23 YP_001590882.1 COG: COG2985 Predicted permease; Psort location: plasma membrane, score: 23 YP_001590883.1 Psort location: nuclear, score: 23 YP_001590884.1 COG: COG1943 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001590885.1 Psort location: cytoplasmic, score: 23 YP_001590886.1 16 kDa heat shock protein B; associates with aggregated proteins, together with ibpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; ATP-independent YP_001590887.1 with IbpB associates with aggregated proteins to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress YP_001590888.1 Psort location: cytoplasmic, score: 23 YP_001590889.1 Psort location: endoplasmic reticulum, score: 9 YP_001590890.1 COG: COG5645 Predicted periplasmic lipoprotein; Psort location: extracellular, including cell wall, score: 9 YP_001590891.1 KEGG: eci:UTI89_C4240 2.3e-187 yidR; hypothetical protein YidR; COG: NOG06296 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001590892.1 KEGG: stm:STM4281 1.4e-20 nrfE; putative methylase K04016; COG: COG3088 Uncharacterized protein involved in biosynthesis of c-type cytochromes; Psort location: endoplasmic reticulum, score: 9 YP_001590893.1 KEGG: azo:azo3929 3.3e-30 ccmG; protein disulfide-isomerase K01829; COG: COG0526 Thiol-disulfide isomerase and THIoredoxins; Psort location: extracellular, including cell wall, score: 9 YP_001590894.1 KEGG: vfi:VF1819 8.1e-217 heme chaperone--apocytochrome heme-lyase K02198; COG: COG1138 Cytochrome c biogenesis factor; Psort location: plasma membrane, score: 23 YP_001590895.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane YP_001590896.1 COG: COG3114 Heme exporter protein D; Psort location: cytoplasmic, score: 23 YP_001590897.1 KEGG: vfi:VF1822 5.2e-80 heme chaperone heme-lyase K02195; COG: COG0755 ABC-type transport system involved in cytochrome c biogenesis, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001590898.1 COG: COG2386 ABC-type transport system involved in cytochrome c biogenesis, permease component; Psort location: endoplasmic reticulum, score: 9 YP_001590899.1 KEGG: stt:t0610 3.0e-91 ccmA; heme exporter protein A1 K02193; COG: COG4133 ABC-type transport system involved in cytochrome c biogenesis, ATPase component; Psort location: cytoplasmic, score: 23 YP_001590900.1 KEGG: stm:STM3820 1.2e-256 putative cytochrome c peroxidase K00428; COG: COG1858 Cytochrome c peroxidase; Psort location: endoplasmic reticulum, score: 9 YP_001590901.1 TorD; involved in the biogenesis of torA; acts on torA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor YP_001590902.1 KEGG: stm:STM3822 0. torA; trimethylamine N-oxide reductase subunit K07811; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: cytoplasmic, score: 23 YP_001590903.1 KEGG: eci:UTI89_C2480 6.1e-45 napC; cytochrome c protein, subunit of nitrate reductase, periplasmic K02569; COG: COG3005 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit; Psort location: nuclear, score: 23 YP_001590904.1 response regulator in two-component regulatory system with TorS; involved in regulation of trimethylamine N-oxide reductase genes YP_001590905.1 periplasmic sensory protein associated with the TorRS two-component regulatory system YP_001590906.1 Psort location: cytoplasmic, score: 23 YP_001590907.1 Member of the two-component regulatory system torS/torR involved in the anaerobic utilization of trimethylamine-N-oxide YP_001590908.1 KEGG: dre:30298 2.8e-05 jak2b; Janus kinase 2b K04447; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001590909.1 KEGG: stm:STM3828 7.2e-209 dgoA; 2-oxo-3-deoxygalactonate 6-phosphate aldolase/galactonate dehydratase K01631:K01684; COG: COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily; Psort location: cytoplasmic, score: 23 YP_001590910.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-galactonate 6-phosphate; functions in galactonate metabolism YP_001590911.1 KEGG: stm:STM3829 2.2e-152 dgoK; 2-oxo-3-deoxygalactonate kinase K00883; COG: COG3734 2-keto-3-deoxy-galactonokinase; Psort location: cytoplasmic, score: 23 YP_001590912.1 COG: COG2186 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001590913.1 YidA; catalyzes the dephosphorylation of erythrose 4-phosphate (preferred substrate), mannose 1-phosphate and p-nitrophenyl phosphate; hydrolyzes the alpha-D-glucose-1-phosphate but not the beta form; member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins YP_001590914.1 KEGG: cal:orf19.4356 0.00098 HGT3; high-affinity glucose transporter K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001590915.1 KEGG: zmo:ZMO1264 1.8e-116 rspA; putative mandelate racemase K01781; COG: COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily; Psort location: cytoplasmic, score: 23 YP_001590916.1 KEGG: shn:Shewana3_3435 6.3e-08 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: vesicles of secretory system, score: 9 YP_001590917.1 negatively supercoils closed circular double-stranded DNA YP_001590918.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA YP_001590919.1 Psort location: cytoplasmic, score: 23 YP_001590920.1 binds the polymerase to DNA and acts as a sliding clamp YP_001590921.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_001590922.1 Psort location: nuclear, score: 23 YP_001590923.1 in Escherichia coli transcription of this gene is enhanced by polyamines YP_001590924.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates YP_001590925.1 KEGG: sec:SC3758 5.5e-12 rnpA; RNase P, protein component (protein C5), processes tRNA, 45S RNA K03536; COG: COG0594 RNase P protein component; Psort location: cytoplasmic, score: 23 YP_001590926.1 KEGG: ttj:TTHA0444 2.1e-05 alpha-hemolysin K08998; COG: COG0759 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001590927.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria YP_001590928.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_001590929.1 Psort location: mitochondrial, score: 23 YP_001590930.1 Confers resistance to chloramphenicol YP_001590931.1 Involved in anaerobic NO protection YP_001590932.1 KEGG: ssn:SSO_3713 1.8e-06 yhhU; hypothetical protein K06133; COG: COG2091 Phosphopantetheinyl transferase; Psort location: mitochondrial, score: 23 YP_001590933.1 KEGG: eci:UTI89_C4266 1.7e-88 yieF; hypothetical protein; COG: COG0431 Predicted flavoprotein; Psort location: cytoplasmic, score: 23 YP_001590934.1 KEGG: bcz:BCZK0244 1.3e-90 guanine-hypoxanTHIne permease; xanTHIne/uracil permease family protein K06901; COG: COG2252 Permeases; Psort location: plasma membrane, score: 23 YP_001590935.1 Psort location: cytoplasmic, score: 23 YP_001590936.1 YieH; catalyzes the dephosphorylation of phosphoenolpyruvate, AMP and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; member of the haloacid dehalogenase-like hydrolases superfamily YP_001590937.1 regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon YP_001590938.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_001590939.1 Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions YP_001590940.1 part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions YP_001590941.1 Psort location: mitochondrial, score: 23 YP_001590942.1 KEGG: mst:Msp_0343 8.0e-09 pstS; PstS K02040; COG: COG0226 ABC-type phosphate transport system, periplasmic component; Psort location: cytoplasmic, score: 23 YP_001590943.1 KEGG: stm:STM3858 2.9e-237 putative phosphotransferase system fructose-specific component IIB K02769:K02770; COG: COG1299 Phosphotransferase system, fructose-specific IIC component; Psort location: plasma membrane, score: 23 YP_001590944.1 catalyzes the conversion of shikimate to 3-dehydroshikimate YP_001590945.1 COG: COG4533 ABC-type uncharacterized transport system, periplasmic component; Psort location: cytoplasmic, score: 23 YP_001590946.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_001590947.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis YP_001590948.1 COG: COG0670 Integral membrane protein, interacts with FtsH; Psort location: plasma membrane, score: 23 YP_001590949.1 KEGG: spt:SPA3703 4.3e-60 atpC; ATP synthase epsilon subunit K02114; COG: COG0355 F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit); Psort location: cytoplasmic, score: 23 YP_001590950.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_001590951.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_001590952.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_001590953.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex YP_001590954.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. YP_001590955.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 YP_001590956.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_001590957.1 COG: COG3312 F0F1-type ATP synthase, subunit I; Psort location: extracellular, including cell wall, score: 23 YP_001590958.1 Psort location: mitochondrial, score: 23 YP_001590959.1 Psort location: cytoplasmic, score: 23 YP_001590960.1 Psort location: cytoplasmic, score: 23 YP_001590961.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA YP_001590962.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_001590963.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_001590964.1 transcriptional repressor of asnA which codes for aspartate-ammonia ligase YP_001590965.1 catalyzes the formation of asparagine from aspartate and ammonia YP_001590966.1 contains a von Willibrand factor type A domain; stimulates the ATPase activity of RavA YP_001590967.1 interacts with LdcI, lysine decarboxylase; may be active in late log/ early stationary phase YP_001590968.1 Responsible for the low-affinity transport of potassium into the cell; involved in potassium ion uptake under hyper-osmotic stress at a low pH YP_001590969.1 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source YP_001590970.1 with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain YP_001590971.1 functions to transport ribose at high affinity; forms a complex with RbsA2C2B YP_001590972.1 periplasmic substrate-binding component of the ATP-dependent ribose transport system YP_001590973.1 catalyzes the formation of D-ribose 5-phosphate from ribose YP_001590974.1 DNA-binding transcriptional repressor of ribose metabolism YP_001590975.1 KEGG: sgl:SG1466 7.9e-09 deTHIobiotin synthase K01935; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001590976.1 COG: COG2186 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001590977.1 Psort location: extracellular, including cell wall, score: 9 YP_001590978.1 Psort location: cytoplasmic, score: 23 YP_001590979.1 Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon YP_001590980.1 COG: COG3085 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001590981.1 among the AAA+ ATPases, the YifB protease family belongs to the Helix 2 insert clade; unknown function YP_001590982.1 Psort location: nuclear, score: 23 YP_001590983.1 catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit YP_001590984.1 KEGG: sec:SC3807 2.8e-40 ilvM; acetolactate synthase II, small subunit K01653; COG: COG3978 Acetolactate synthase (isozyme II), small (regulatory) subunit; Psort location: cytoplasmic, score: 23 YP_001590985.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_001590986.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_001590987.1 threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway YP_001590988.1 COG: COG4679 Phage-related protein; Psort location: cytoplasmic, score: 23 YP_001590989.1 COG: COG5606 Uncharacterized conserved small protein; Psort location: cytoplasmic, score: 23 YP_001590990.1 participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate YP_001590991.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_001590992.1 KEGG: spt:SPA3749 1.2e-46 ppiC; peptidyl-prolyl cis-trans isomerase C K03769; COG: COG0760 Parvulin-like peptidyl-prolyl isomerase; Psort location: cytoplasmic, score: 23 YP_001590993.1 Psort location: cytoplasmic, score: 23 YP_001590994.1 COG: COG3201 Nicotinamide mononucleotide transporter; Psort location: cytoplasmic, score: 23 YP_001590995.1 single-stranded DNA-dependent ATPase; initiates unwinding at a nick in the DNA; involved in DNA replication YP_001590996.1 catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation YP_001590997.1 enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation YP_001590998.1 KEGG: eci:UTI89_C4335 4.1e-55 trxA; THIoredoxin 1 K03671; COG: COG0526 Thiol-disulfide isomerase and THIoredoxins; Psort location: cytoplasmic, score: 23 YP_001590999.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_001591000.1 KEGG: spt:SPA3758 2.1e-193 rfe; putative undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase K02851; COG: COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase; Psort location: plasma membrane, score: 23 YP_001591001.1 Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein YP_001591002.1 KEGG: stm:STM3920 8.0e-194 wecB; UDP-N-acetyl glucosamine -2-epimerase K01791; COG: COG0381 UDP-N-acetylglucosamine 2-epimerase; Psort location: cytoplasmic, score: 23 YP_001591003.1 catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid YP_001591004.1 KEGG: stm:STM3922 9.2e-193 rffG; dTDP-glucose 4,6-dehydratase K01710; COG: COG1088 dTDP-D-glucose 4,6-dehydratase; Psort location: extracellular, including cell wall, score: 9 YP_001591005.1 KEGG: sty:STY3632 2.0e-156 rffH; glucose-1-phosphate thymidylyltransferase K00973; COG: COG1209 dTDP-glucose pyrophosphorylase; Psort location: cytoplasmic, score: 23 YP_001591006.1 KEGG: eci:UTI89_C4346 3.6e-88 rffC, rff, wecD, yifH; TDP-fucosamine acetyltransferase K00680; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001591007.1 catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis YP_001591008.1 COG: COG2244 Membrane protein involved in the export of O-antigen and teichoic acid; Psort location: plasma membrane, score: 23 YP_001591009.1 catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis YP_001591010.1 enterobacterial common antigen polymerase YP_001591011.1 KEGG: stm:STM3929 1.9e-130 wecG; putative UDP-N-acetyl-D-mannosaminuronic acid transferase K02852; COG: COG1922 Teichoic acid biosynthesis proteins; Psort location: cytoplasmic, score: 23 YP_001591012.1 uncharacterized member of the amino acid-polyamine-organocation (APC) superfamily of amino acid transporters; unknown function YP_001591013.1 Psort location: cytoplasmic, score: 23 YP_001591014.1 Psort location: mitochondrial, score: 23 YP_001591015.1 KEGG: pfo:Pfl_0690 0.0075 exodeoxyribonuclease V, alpha subunit K03581; COG: COG3071 Uncharacterized enzyme of heme biosynthesis; Psort location: endoplasmic reticulum, score: 9 YP_001591016.1 KEGG: stm:STM3936 1.2e-197 hemX; uroporphyrinogen III methylase K02496; COG: COG2959 Uncharacterized enzyme of heme biosynthesis; Psort location: nuclear, score: 23 YP_001591017.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis YP_001591018.1 KEGG: sec:SC3839 1.0e-147 hemC; porphobilinogen deaminase (hydroxymethylbilane synthase) K01749; COG: COG0181 Porphobilinogen deaminase; Psort location: cytoplasmic, score: 23 YP_001591019.1 Psort location: mitochondrial, score: 23 YP_001591020.1 catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP YP_001591021.1 COG: NOG29033 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001591022.1 Psort location: nuclear, score: 23 YP_001591023.1 COG: NOG25317 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591024.1 COG: NOG27704 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591025.1 defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly YP_001591026.1 KEGG: rpr:RP825 0.00032 mraY2; undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase K02851; COG: NOG29596 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001591027.1 COG: NOG06292 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001591028.1 Psort location: cytoplasmic, score: 23 YP_001591029.1 Psort location: endoplasmic reticulum, score: 9 YP_001591030.1 COG: COG5567 Predicted small periplasmic lipoprotein; Psort location: extracellular, including cell wall, score: 9 YP_001591031.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate YP_001591032.1 KEGG: azo:azo0595 1.9e-05 3',5'-cyclic-nucleotide phosphodiesterase K01120; COG: COG3159 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001591033.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_001591034.1 YigB; member of the haloacid dehalogenase (HAD)-like hydrolases superfamily of protein; unknown function YP_001591035.1 unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair. YP_001591036.1 Psort location: nuclear, score: 23 YP_001591037.1 responsible for the influx of magnesium ions YP_001591038.1 Psort location: endoplasmic reticulum, score: 9 YP_001591039.1 Psort location: endoplasmic reticulum, score: 9 YP_001591040.1 COG: COG2962 Predicted permeases; Psort location: endoplasmic reticulum, score: 9 YP_001591041.1 COG: COG2050 Uncharacterized protein, possibly involved in aromatic compounds catabolism; Psort location: cytoplasmic, score: 23 YP_001591042.1 catalyzes the hydrolysis of phosphatidylcholine YP_001591043.1 functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway YP_001591044.1 COG: COG1280 Putative threonine efflux protein; Psort location: endoplasmic reticulum, score: 9 YP_001591045.1 COG: COG1280 Putative threonine efflux protein; Psort location: endoplasmic reticulum, score: 9 YP_001591046.1 lecithinase B; catalyzes the conversion of 1-lysophosphatidylcholine to glycerophosphocholine; can also hydrolyze 2-acyl glycerophosphoethanolamine and other substrates YP_001591047.1 purine and pyrimidine nucleotides are secondary substrates; yigL expression is regulated by heat shock, osmotic shock and starvation of glucose, phosphate or ammonium YP_001591048.1 Psort location: nuclear, score: 23 YP_001591049.1 KEGG: shn:Shewana3_3435 4.4e-11 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001591050.1 Psort location: nuclear, score: 23 YP_001591051.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine YP_001591052.1 Psort location: mitochondrial, score: 23 YP_001591053.1 Psort location: cytoplasmic, score: 23 YP_001591054.1 KEGG: syg:sync_2368 2.0e-16 arylsulfatase regulator; COG: COG0641 Arylsulfatase regulator (Fe-S oxidoreductase); Psort location: cytoskeletal, score: 9 YP_001591055.1 KEGG: stm:STM3967 1.6e-147 dlhH; putative dienelactone hydrolase family K01061; COG: COG0412 Dienelactone hydrolase and related enzymes; Psort location: cytoplasmic, score: 23 YP_001591056.1 catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway YP_001591057.1 YigN; nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence; transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner YP_001591058.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone YP_001591059.1 COG: COG3165 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001591060.1 an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions YP_001591061.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes YP_001591062.1 mediates the export of protein precursors bearing twin-arginine signal peptides YP_001591063.1 with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane YP_001591064.1 magnesium dependent; not involved in the Sec-independent protein export system YP_001591065.1 COG: COG0250 Transcription antiterminator; Psort location: cytoplasmic, score: 23 YP_001591066.1 Psort location: cytoplasmic, score: 23 YP_001591067.1 catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol YP_001591068.1 NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin YP_001591069.1 KEGG: ecp:ECP_3130 5.1e-112 arylsulfate sulfotransferase K01023; COG: NOG06306 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001591070.1 FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids YP_001591071.1 includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids YP_001591072.1 catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters YP_001591073.1 KEGG: eci:UTI89_C4433 1.2e-94 yigZ; hypothetical protein K00560; COG: COG1739 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001591074.1 KEGG: shn:Shewana3_0031 1.1e-77 potassium uptake protein, TrkH family K00961; COG: COG0168 Trk-type K+ transport systems, membrane components; Psort location: plasma membrane, score: 23 YP_001591075.1 catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX YP_001591076.1 Psort location: extracellular, including cell wall, score: 9 YP_001591077.1 Psort location: cytoplasmic, score: 23 YP_001591078.1 Psort location: cytoplasmic, score: 23 YP_001591079.1 in Escherichia coli the MobB protein is not essential but has been found to interact with multiple proteins involved in the molybdopterin guanine dinucleotide cofactor biosynthesis pathway YP_001591080.1 in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis YP_001591081.1 COG: COG3084 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001591082.1 catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages YP_001591083.1 KEGG: bci:BCI_0257 3.0e-52 dsbA; THIol:disulfide interchange protein DsbA K01829; COG: COG0526 Thiol-disulfide isomerase and THIoredoxins; Psort location: extracellular, including cell wall, score: 9 YP_001591084.1 KEGG: eci:UTI89_C4450 1.8e-132 yihG; hypothetical protein YihG K00655; COG: COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase; Psort location: cytoplasmic, score: 23 YP_001591085.1 Psort location: nuclear, score: 23 YP_001591086.1 Psort location: nuclear, score: 23 YP_001591087.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair YP_001591088.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential YP_001591089.1 COG: COG3078 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001591090.1 Psort location: nuclear, score: 23 YP_001591091.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_001591092.1 Psort location: nuclear, score: 23 YP_001591093.1 response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes; interacts with sigma-54 YP_001591094.1 sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation YP_001591095.1 forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme YP_001591096.1 Psort location: cytoplasmic, score: 23 YP_001591097.1 KEGG: eci:UTI89_C4460 0. typA, bipA, yihK, yjhK; putative GTP-binding factor K06207; COG: COG1217 Predicted membrane GTPase involved in stress response; Psort location: cytoplasmic, score: 23 YP_001591098.1 COG: NOG11939 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591099.1 porin involved in the transport of small molecular weight solutes (up to 600 Daltons) across the cell wall; specific substrate still unknown YP_001591100.1 KEGG: eci:UTI89_C4210 3.0e-43 yicJ; hypothetical symporter YicJ K03292; COG: COG2211 Na+/melibiose symporter and related transporters; Psort location: plasma membrane, score: 23 YP_001591101.1 KEGG: eci:UTI89_C4210 9.4e-49 yicJ; hypothetical symporter YicJ K03292; COG: COG2211 Na+/melibiose symporter and related transporters; Psort location: plasma membrane, score: 23 YP_001591102.1 KEGG: lil:LA2944 2.1e-129 Alpha-glucosidase II K01187; COG: COG1501 Alpha-glucosidases, family 31 of glycosyl hydrolases; Psort location: cytoplasmic, score: 23 YP_001591103.1 COG: COG0730 Predicted permeases; Psort location: plasma membrane, score: 23 YP_001591104.1 KEGG: eco:b3879 1.7e-111 yihR; predicted aldose-1-epimerase K01785; COG: COG2017 Galactose mutarotase and related enzymes; Psort location: cytoplasmic, score: 23 YP_001591105.1 KEGG: eco:b3880 2.7e-232 yihS; predicted glucosamine isomerase; COG: COG2942 N-acyl-D-glucosamine 2-epimerase; Psort location: cytoplasmic, score: 23 YP_001591106.1 KEGG: eco:b3881 1.2e-133 yihT; predicted aldolase; COG: COG3684 Tagatose-1,6-bisphosphate aldolase; Psort location: cytoplasmic, score: 23 YP_001591107.1 KEGG: spt:SPA3864 2.5e-151 yihU; putative oxidoreductase K08318; COG: COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001591108.1 Psort location: cytoplasmic, score: 23 YP_001591109.1 KEGG: eci:UTI89_C4462 8.8e-101 yihV; hypothetical sugar kinase YihV K00846; COG: COG0524 Sugar kinases, ribokinase family; Psort location: extracellular, including cell wall, score: 9 YP_001591110.1 COG: COG1349 Transcriptional regulators of sugar metabolism; Psort location: cytoplasmic, score: 23 YP_001591111.1 KEGG: lil:LA1476 8.1e-11 putative haloacid dehalogenase-like hydrolase K01560; COG: COG1011 Predicted hydrolase (HAD superfamily); Psort location: cytoplasmic, score: 23 YP_001591112.1 RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease YP_001591113.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine YP_001591114.1 KEGG: eci:UTI89_C4472 7.3e-168 yiiD; putative acetyltransferase K00633; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001591115.1 COG: COG5499 Predicted transcription regulator containing HTH domain; Psort location: nuclear, score: 23 YP_001591116.1 COG: COG4680 Uncharacterized protein conserved in bacteria; Psort location: cytoskeletal, score: 9 YP_001591117.1 KEGG: ecp:ECP_4098 1.4e-125 acetyl-hydrolase K01066; COG: COG0657 Esterase/lipase; Psort location: cytoplasmic, score: 23 YP_001591118.1 Psort location: nuclear, score: 23 YP_001591119.1 COG: NOG13906 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591120.1 COG: NOG18543 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591121.1 required for the formation of active formate dehydrogenase YP_001591122.1 cytochrome b556(FDO) component; heme containing YP_001591123.1 KEGG: stm:STM4036 1.9e-169 fdoH; formate dehydrogenase-O, Fe-S subunit K00124; COG: COG0437 Fe-S-cluster-containing hydrogenase components 1; Psort location: cytoplasmic, score: 23 YP_001591124.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth YP_001591125.1 Psort location: cytoplasmic, score: 23 YP_001591126.1 COG: NOG24908 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001591127.1 KEGG: cal:orf19.4334 0.00049 hypothetical protein K00960; COG: NOG06877 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001591128.1 Psort location: cytoplasmic, score: 23 YP_001591129.1 COG: NOG19750 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001591130.1 COG: COG1296 Predicted branched-chain amino acid permease (azaleucine resistance); Psort location: endoplasmic reticulum, score: 9 YP_001591131.1 KEGG: psp:PSPPH_2917 2.5e-09 DNA-binding protein K00517; COG: COG1396 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001591132.1 Psort location: nuclear, score: 23 YP_001591133.1 KEGG: msm:MSMEG_0587 1.7e-08 rhaU; L-rhamnose 1-epimerase; COG: COG3254 Uncharacterized conserved protein; Psort location: cytoskeletal, score: 9 YP_001591134.1 KEGG: stm:STM4044 1.7e-200 putative alcohol dehydrogenase K00001; COG: COG1454 Alcohol dehydrogenase, class IV; Psort location: mitochondrial, score: 23 YP_001591135.1 KEGG: sec:SC3935 1.8e-148 rhaD; rhamnulose-1-phosphate aldolase K01629; COG: COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases; Psort location: cytoplasmic, score: 23 YP_001591136.1 catalyzes the formation of L-rhamnulose from L-rhamnose YP_001591137.1 catalyzes the ATP-dependent phosphorylation of rhamnulose YP_001591138.1 Psort location: nuclear, score: 23 YP_001591139.1 activates the expression of the rhaBAD operon and rhaT gene YP_001591140.1 activates the expression of rhaRS in response to L-rhamnose YP_001591141.1 transports L-rhamnose and L-lyxose into the cell YP_001591142.1 Psort location: endoplasmic reticulum, score: 9 YP_001591143.1 Psort location: cytoskeletal, score: 9 YP_001591144.1 Psort location: cytoplasmic, score: 23 YP_001591145.1 COG: NOG25848 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001591146.1 COG: COG1593 TRAP-type C4-dicarboxylate transport system, large permease component; Psort location: plasma membrane, score: 23 YP_001591147.1 COG: COG3090 TRAP-type C4-dicarboxylate transport system, small permease component; Psort location: endoplasmic reticulum, score: 9 YP_001591148.1 COG: COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001591149.1 Psort location: mitochondrial, score: 23 YP_001591150.1 KEGG: stt:t3564 5.0e-98 sodA; manganese superoxide dismutase K04564; COG: COG0605 Superoxide dismutase; Psort location: cytoplasmic, score: 23 YP_001591151.1 COG: COG2258 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001591152.1 COG: NOG14135 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591153.1 KEGG: hal:VNG1169C 0.00065 DNA-directed RNA polymerase subunit F K03051; Psort location: cytoplasmic, score: 23 YP_001591154.1 part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors YP_001591155.1 response regulator in two-component regulatory system with CpxA; part of the envelope stress response system YP_001591156.1 repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates YP_001591157.1 member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers YP_001591158.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis YP_001591159.1 Psort location: nuclear, score: 23 YP_001591160.1 COG: COG1613 ABC-type sulfate transport system, periplasmic component; Psort location: extracellular, including cell wall, score: 9 YP_001591161.1 KEGG: sec:SC3955 1.6e-133 ushB; CDP-diacylglycerol phosphotidylhydrolase K01521; COG: COG2134 CDP-diacylglycerol pyrophosphatase; Psort location: endoplasmic reticulum, score: 9 YP_001591162.1 KEGG: eci:UTI89_C4210 6.8e-78 yicJ; hypothetical symporter YicJ K03292; COG: COG2211 Na+/melibiose symporter and related transporters; Psort location: plasma membrane, score: 23 YP_001591163.1 phosphorylates aminoimidazole ribotide (AIR) which forms 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P); synthesis of HMP-P from AIR is complex and requires the product of thiC gene at least YP_001591164.1 KEGG: sdy:SDY_2272 8.5e-32 hypothetical protein K05521; COG: COG1397 ADP-ribosylglycohydrolase; Psort location: cytoplasmic, score: 23 YP_001591165.1 KEGG: bcz:BCZK3111 8.1e-10 transcriptional regulator, GntR family; COG: COG2188 Transcriptional regulators; Psort location: nuclear, score: 23 YP_001591166.1 COG: COG2134 CDP-diacylglycerol pyrophosphatase; Psort location: cytoplasmic, score: 23 YP_001591167.1 KEGG: spt:SPA3907 3.8e-13 cdh; CDP-diglyceride hydrolase K01521; COG: COG2134 CDP-diacylglycerol pyrophosphatase; Psort location: cytoplasmic, score: 23 YP_001591168.1 COG: COG1917 Uncharacterized conserved protein, contains double-stranded beta-helix domain; Psort location: cytoplasmic, score: 23 YP_001591169.1 KEGG: bca:BCE_3017 1.4e-150 sugar kinase, FGGY family, putative K00851; COG: COG1070 Sugar (pentulose and hexulose) kinases; Psort location: cytoplasmic, score: 23 YP_001591170.1 KEGG: rde:RD1_3614 2.2e-31 glycerone kinase, putative K00863; COG: COG2390 Transcriptional regulator, contains sigma factor-related N-terminal domain; Psort location: cytoplasmic, score: 23 YP_001591171.1 Psort location: nuclear, score: 23 YP_001591172.1 KEGG: spt:SPA3917 1.4e-269 ego; putative ABC transporter ATP-binding protein K02056; COG: COG1129 ABC-type sugar transport system, ATPase component; Psort location: cytoplasmic, score: 23 YP_001591173.1 KEGG: msm:MSMEG_3090 5.9e-40 ribose transport system permease protein RbsC; COG: COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components; Psort location: endoplasmic reticulum, score: 9 YP_001591174.1 KEGG: eco:b4460 1.2e-30 araH; fused L-arabinose transporter subunits of ABC superfamily: membrane components K02057; COG: COG1172 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components; Psort location: plasma membrane, score: 23 YP_001591175.1 KEGG: msm:MSMEG_3095 2.1e-05 D-ribose-binding periplasmic protein; COG: COG1879 ABC-type sugar transport system, periplasmic component; Psort location: endoplasmic reticulum, score: 9 YP_001591176.1 KEGG: spt:SPA3921 7.4e-152 yneB; putative aldolase K08321; COG: COG1830 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes; Psort location: cytoplasmic, score: 23 YP_001591177.1 COG: COG1359 Uncharacterized conserved protein; Psort location: endoplasmic reticulum, score: 9 YP_001591178.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate YP_001591179.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate YP_001591180.1 COG: NOG06218 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001591181.1 COG: COG3152 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001591182.1 Psort location: mitochondrial, score: 23 YP_001591183.1 KEGG: stm:STM4084 1.6e-131 fpr; ferredoxin-NADP reductase K00528; COG: COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1; Psort location: cytoplasmic, score: 23 YP_001591184.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese YP_001591185.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP YP_001591186.1 KEGG: fal:FRAAL3366 0.0025 putative arsenate reductase (partial match); COG: COG0580 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family); Psort location: endoplasmic reticulum, score: 9 YP_001591187.1 Psort location: mitochondrial, score: 23 YP_001591188.1 KEGG: rno:85240 0.00031 Plcb2; phospholipase C, beta 2 K05858; COG: COG3074 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001591189.1 Psort location: mitochondrial, score: 23 YP_001591190.1 KEGG: eci:UTI89_C4513 5.3e-55 menG, rraA, yiiV; ribonuclease E inhibitor subunit K02553; COG: COG0684 Demethylmenaquinone methyltransferase; Psort location: cytoplasmic, score: 23 YP_001591191.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate YP_001591192.1 heat shock protein involved in degradation of misfolded proteins YP_001591193.1 heat shock protein involved in degradation of misfolded proteins YP_001591194.1 KEGG: pfo:Pfl_1900 3.2e-07 argininosuccinate synthase K03749; COG: COG3087 Cell division protein; Psort location: nuclear, score: 23 YP_001591195.1 Psort location: cytoplasmic, score: 23 YP_001591196.1 negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins YP_001591197.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity YP_001591198.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_001591199.1 COG: NOG18542 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001591200.1 KEGG: ecc:c3785 5.7e-129 assT; arylsulfate sulfotransferase K01023; COG: NOG06306 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591201.1 Psort location: cytoplasmic, score: 23 YP_001591202.1 Psort location: cytoplasmic, score: 23 YP_001591203.1 Psort location: cytoplasmic, score: 23 YP_001591204.1 when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis YP_001591205.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine YP_001591206.1 multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways YP_001591207.1 COG: COG0668 Small-conductance mechanosensitive channel; Psort location: endoplasmic reticulum, score: 9 YP_001591208.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001591209.1 COG: NOG06319 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591210.1 KEGG: eci:UTI89_C4530 9.5e-262 hypothetical protein K01081; COG: COG0737 5-nucleotidase/2,3-cyclic phosphodiesterase and related esterases; Psort location: extracellular, including cell wall, score: 9 YP_001591211.1 MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor YP_001591212.1 KEGG: stm:STM4106 0. katG; catalase; hydroperoxidase HPI(I) K03782; COG: COG0376 Catalase (peroxidase I); Psort location: endoplasmic reticulum, score: 9 YP_001591213.1 COG: COG3738 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001591214.1 Psort location: nuclear, score: 23 YP_001591215.1 forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone YP_001591216.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies YP_001591217.1 KEGG: sec:SC4002 0. ptsA; general PTS family, enzyme I K02766:K02768; COG: COG1762 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type); Psort location: cytoplasmic, score: 23 YP_001591218.1 Psort location: mitochondrial, score: 23 YP_001591219.1 FrwC with FrwB, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; forms translocation channel and contains the specific substrate-binding site YP_001591220.1 FrwB with FrwC, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system (PTS) permease which may phosphorylate and transport sugars into the cell; cytoplasmic protein that interacts with complex EIIA; contains the second phosphorylation site of the PTS YP_001591221.1 involved in production of D-lactate from glucose under microaerobic conditions; cytoplasmic protein YP_001591222.1 KEGG: stm:STM4115 1.2e-149 pflC; putative pyruvate formate lyase activating enzyme 2 K04069; COG: COG1180 Pyruvate-formate lyase-activating enzyme; Psort location: cytoplasmic, score: 23 YP_001591223.1 FrwD with FrwB, FrwC and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; phosphorylated by EIIA; FrwB homolog YP_001591224.1 KEGG: bli:BL05281 1.4e-11 adaA; methylphosphotriester-DNA alkyltransferase and transcriptional regulator (AraC/XylS family) K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001591225.1 Psort location: cytoplasmic, score: 23 YP_001591226.1 KEGG: pha:PSHAa2772 8.6e-22 eptA; lipid A phosphoethanolamine transferase, associated with polymyxin resistance K03760; COG: COG2194 Predicted membrane-associated, metal-dependent hydrolase; Psort location: endoplasmic reticulum, score: 9 YP_001591227.1 Psort location: cytoplasmic, score: 23 YP_001591228.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate YP_001591229.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis YP_001591230.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate YP_001591231.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate YP_001591232.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_001591233.1 Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA YP_001591234.1 catalyzes the conversion of NADPH to NADH YP_001591235.1 negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis YP_001591236.1 COG: NOG10261 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001591237.1 catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs YP_001591238.1 involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space YP_001591239.1 converts L-glutamate to D-glutamate, a component of peptidoglycan YP_001591240.1 Psort location: extracellular, including cell wall, score: 9 YP_001591241.1 Psort location: cytoplasmic, score: 23 YP_001591242.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_001591243.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon YP_001591244.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis YP_001591245.1 COG: NOG15364 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001591246.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_001591247.1 Psort location: endoplasmic reticulum, score: 9 YP_001591248.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_001591249.1 Modulates Rho-dependent transcription termination YP_001591250.2 KEGG: reh:H16_A3501 1.9e-34 rplK; LSU ribosomal protein L11 K00001; COG: COG0080 Ribosomal protein L11; Psort location: cytoplasmic, score: 23 YP_001591251.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_001591252.1 Psort location: nuclear, score: 23; ORF located using Blastx YP_001591253.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_001591255.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_001591256.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_001591257.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_001591258.1 Psort location: endoplasmic reticulum, score: 9 YP_001591259.1 COG: NOG37236 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591260.1 Psort location: cytoplasmic, score: 23 YP_001591261.1 Psort location: cytoplasmic, score: 23 YP_001591262.1 Psort location: nuclear, score: 23 YP_001591263.1 in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center YP_001591264.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate YP_001591265.1 with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate YP_001591266.1 KEGG: eci:UTI89_C3827 8.1e-114 THIF; adenylyltransferase ThiF K03148; COG: COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and THIamine biosynthesis family 2; Psort location: cytoplasmic, score: 23 YP_001591267.1 catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate YP_001591268.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine YP_001591269.1 binds specifically to the major sigma factor sigma 70; active in stationary phase YP_001591270.1 can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates YP_001591271.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III YP_001591272.1 Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA; cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures YP_001591273.1 COG: COG3068 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001591274.1 histone-like DNA-binding protein YP_001591275.1 COG: NOG06219 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591276.1 COG: COG3678 P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein; Psort location: extracellular, including cell wall, score: 9 YP_001591277.1 KEGG: sec:SC4054 1.0e-273 hydH, hydG; sensory kinase in two component regulatory system with HydG K07709; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 9 YP_001591278.1 DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein YP_001591279.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_001591280.1 involved in de novo purine biosynthesis YP_001591281.1 Psort location: cytoplasmic, score: 23 YP_001591282.1 Psort location: cytoplasmic, score: 23 YP_001591283.1 Psort location: cytoplasmic, score: 23 YP_001591284.1 KEGG: spt:SPA4019 4.9e-75 yjaB; putative acetyltransferase K03827; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001591285.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis YP_001591286.1 Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle YP_001591287.1 KEGG: spt:SPA4022 3.4e-234 aceA; isocitrate lyase K01637; COG: COG2224 Isocitrate lyase; Psort location: cytoplasmic, score: 23 YP_001591288.1 Psort location: cytoplasmic, score: 23 YP_001591289.1 catalyzes the phosphorylation/dephosphorylation of the enzyme isocitrate dehydrogenase on a specific serine which regulates activity; unphosphorylated IDH is fully active when cells are grown on glucose while the enzyme becomes phosphorylated and inactive in the presence of acetate or ethanol YP_001591290.1 COG: COG4405 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001591291.1 regulates the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase and isocitrate dehydrogenase kinase/phosphorylase YP_001591292.1 one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity YP_001591293.1 COG: COG1283 Na+/phosphate symporter; Psort location: plasma membrane, score: 23 YP_001591294.1 alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family YP_001591295.1 Psort location: cytoplasmic, score: 23 YP_001591296.1 COG: COG3122 Uncharacterized protein conserved in bacteria; Psort location: mitochondrial, score: 23 YP_001591297.1 catalyzes the synthesis of pseudouridine from U-2604 in the 23S ribosomal RNA YP_001591298.1 COG: NOG14139 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001591299.1 COG: COG1349 Transcriptional regulators of sugar metabolism; Psort location: cytoplasmic, score: 23 YP_001591300.1 KEGG: aha:AHA_0482 4.5e-26 phosphatase YidA K01112; COG: COG0561 Predicted hydrolases of the HAD superfamily; Psort location: cytoplasmic, score: 23 YP_001591301.1 KEGG: bcz:BCZK2256 1.0e-05 fba; fructose-bisphosphate aldolase, class II K01624; COG: NOG26735 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591302.1 KEGG: lmf:LMOf2365_2305 1.4e-10 PTS system, fructose-specific, IIABC component K02768:K02769:K02770; COG: NOG14140 non supervised orthologous group; Psort location: plasma membrane, score: 23 YP_001591303.1 Psort location: mitochondrial, score: 23 YP_001591304.1 Psort location: cytoplasmic, score: 23 YP_001591305.1 Psort location: endoplasmic reticulum, score: 9 YP_001591306.1 KEGG: cjk:jk0393 4.5e-16 cysE; hypothetical protein K00640; COG: COG1045 Serine acetyltransferase; Psort location: cytoplasmic, score: 23 YP_001591307.1 COG: COG5566 Uncharacterized conserved protein; Psort location: nuclear, score: 23 YP_001591308.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive YP_001591309.1 Psort location: nuclear, score: 23 YP_001591310.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_001591311.1 Psort location: nuclear, score: 23 YP_001591312.1 KEGG: sag:SAG1941 0.0079 cpdB; 2',3'-cyclic-nucleotide 2'-phosphodiesterase K01119; COG: NOG14141 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001591313.1 COG: NOG06220 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001591314.1 COG: NOG06780 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001591315.1 COG: NOG06257 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001591316.1 COG: COG3223 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001591317.1 with MalKFE is involved in the transport of maltose into the cell YP_001591318.1 with MalKGE is involved in maltose transport into the cell YP_001591319.1 functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis YP_001591320.1 Psort location: nuclear, score: 23 YP_001591321.1 with malEFG is involved in import of maltose/maltodextrin YP_001591322.1 porin involved in the transport of maltose and maltodextrins YP_001591323.1 Psort location: cytoplasmic, score: 23 YP_001591324.1 COG: NOG06298 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001591325.1 KEGG: sbo:SBO_4078 7.1e-05 ubiC; chorismate lyase K03181; Psort location: endoplasmic reticulum, score: 9 YP_001591326.1 catalyzes the formation of 4-hydroxybenzoate from chorismate YP_001591327.1 catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway YP_001591328.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA YP_001591329.1 KEGG: sty:STY4432 4.3e-60 dgkA; diacylglycerol kinase K00901; COG: COG0818 Diacylglycerol kinase; Psort location: endoplasmic reticulum, score: 9 YP_001591330.1 Represses a number of genes involved in the response to DNA damage YP_001591331.1 COG: COG0534 Na+-driven multidrug efflux pump; Psort location: plasma membrane, score: 23 YP_001591332.1 Psort location: nuclear, score: 23 YP_001591333.1 unknown function; highly abundant protein in vivo; overexpressed under high NaCl concentrations; part of the sigma S regulon; non-essential YP_001591334.1 Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB YP_001591335.1 COG: NOG11280 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001591336.1 KEGG: spt:SPA4060 1.3e-179 yjbN; tRNA-dihydrouridine synthase A K05539; COG: COG0042 tRNA-dihydrouridine synthase; Psort location: cytoplasmic, score: 23 YP_001591337.1 Psort location: mitochondrial, score: 23 YP_001591338.1 coordinately regulated along with pspA; PspF-dependent induction in response to secretin overexpression in Yersinia YP_001591339.1 KEGG: spt:SPA4062 5.6e-170 qor; quinone oxidoreductase K00344; COG: COG0604 NADPH:quinone reductase and related Zn-dependent oxidoreductases; Psort location: cytoplasmic, score: 23 YP_001591340.1 unwinds double stranded DNA YP_001591341.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer YP_001591342.1 Psort location: nuclear, score: 23 YP_001591343.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate YP_001591344.1 Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity YP_001591345.1 COG: COG0432 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001591346.1 COG: COG2315 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001591347.1 COG: NOG29606 non supervised orthologous group; Psort location: vesicles of secretory system, score: 9 YP_001591348.1 COG: NOG26992 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001591349.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate YP_001591350.1 binds to single stranded DNA and PriA helcase facilitate replication restart YP_001591351.1 Psort location: cytoplasmic, score: 23 YP_001591352.1 Psort location: nuclear, score: 23 YP_001591353.1 Psort location: nuclear, score: 23 YP_001591354.1 Psort location: endoplasmic reticulum, score: 9 YP_001591355.1 Psort location: nuclear, score: 23 YP_001591356.1 KEGG: vpa:VPA0477 0.0053 beta-lactamase K01467; COG: NOG26663 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001591357.1 KEGG: cal:orf19.2684 0.0032 SLK192; conserved coiled-coil protein K00870; COG: NOG07819 non supervised orthologous group; Psort location: plasma membrane, score: 23 YP_001591358.1 KEGG: msy:MS53_0544 0.0091 pcrA; ATP-dependent helicase K03657; COG: COG1538 Outer membrane protein; Psort location: extracellular, including cell wall, score: 9 YP_001591359.1 KEGG: fnu:FN0522 7.6e-06 exonuclease SBCC K03546; COG: COG0845 Membrane-fusion protein; Psort location: endoplasmic reticulum, score: 9 YP_001591360.1 KEGG: chu:CHU_2852 3.6e-23 CHU large protein; candidate b-glycosidase, glycoside hydrolase family 8 protein K01238; COG: NOG16062 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591361.1 KEGG: pen:PSEEN0144 3.8e-52 type I toxin efflux ATP-binding protein; COG: COG2274 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain; Psort location: plasma membrane, score: 23 YP_001591362.1 COG: NOG13912 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001591363.1 Psort location: mitochondrial, score: 23 YP_001591364.1 Psort location: nuclear, score: 23 YP_001591365.1 KEGG: eci:UTI89_C1702 3.0e-35 hypothetical protein; COG: COG4943 Predicted signal transduction protein containing sensor and EAL domains; Psort location: endoplasmic reticulum, score: 9 YP_001591366.1 regulates genes involved in response to oxidative stress YP_001591367.1 KEGG: eci:UTI89_C3737 4.8e-06 yhdM; Zn(II)-responsive regulator of ZntA; COG: COG0789 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001591368.1 Psort location: nuclear, score: 23 YP_001591369.1 KEGG: xcc:XCC2286 8.3e-57 gstA; glutaTHIone S-transferase K00799; COG: COG0625 GlutaTHIone S-transferase; Psort location: cytoplasmic, score: 23 YP_001591370.1 Psort location: nuclear, score: 23 YP_001591371.1 KEGG: bcz:BCZK0244 2.9e-61 guanine-hypoxanTHIne permease; xanTHIne/uracil permease family protein K06901; COG: COG2252 Permeases; Psort location: plasma membrane, score: 23 YP_001591372.1 Psort location: nuclear, score: 23 YP_001591373.1 KEGG: shn:Shewana3_3435 1.7e-58 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001591374.1 KEGG: btk:BT9727_3424 2.7e-12 murein hydrolase exporter K06518; COG: COG1380 Putative effector of murein hydrolase LrgA; Psort location: endoplasmic reticulum, score: 9 YP_001591375.1 KEGG: bcz:BCZK3376 8.9e-37 murein hydrolase export regulator K01238; COG: COG1346 Putative effector of murein hydrolase; Psort location: endoplasmic reticulum, score: 9 YP_001591376.1 member of the sodium:solute symporter family; cotranscribed with the acs gene which encodes acetyl coenzyme A synthase; mutations affect acetate uptake YP_001591377.1 COG: COG3162 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001591378.1 Psort location: cytoplasmic, score: 23 YP_001591379.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA YP_001591380.1 Psort location: cytoplasmic, score: 23 YP_001591381.1 catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552 YP_001591382.1 part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia YP_001591383.1 KEGG: vfi:VF1552 1.8e-77 THIosulfate reductase electron transport subunit K04014; COG: COG0437 Fe-S-cluster-containing hydrogenase components 1; Psort location: mitochondrial, score: 23 YP_001591384.1 KEGG: pai:PAE2861 2.1e-19 molybdopterin oxidoreductase, membrane subunit K00185; COG: COG3301 Formate-dependent nitrite reductase, membrane component; Psort location: plasma membrane, score: 23 YP_001591385.1 with NrfF and NrfG catalyzes the insertion of heme into cytochrome c552 YP_001591386.1 COG: COG4235 Cytochrome c biogenesis factor; Psort location: nuclear, score: 23 YP_001591387.1 Psort location: mitochondrial, score: 23 YP_001591388.1 carrier protein part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system YP_001591389.1 Psort location: nuclear, score: 23 YP_001591390.1 KEGG: eci:UTI89_C1133 1.3e-14 hypothetical protein; COG: COG0790 FOG: TPR repeat, SEL1 subfamily; Psort location: extracellular, including cell wall, score: 9 YP_001591391.1 Psort location: cytoplasmic, score: 23 YP_001591392.1 Psort location: mitochondrial, score: 23 YP_001591393.1 KEGG: xoo:XOO0232 4.0e-96 aspH; aspartyl-asparaginyl beta-hydroxylase K00476; COG: COG3555 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases; Psort location: endoplasmic reticulum, score: 9 YP_001591394.1 PhnO in Salmonella enterica catalyzes the acetylation of a range of aminoalkylphosphonic acids; part of the biochemical pathway that enables the cell to use phosphonates as a phosphorus source; Escherichia coli uses a different mechanism of phosphonate catabolism where PhnO is not essential and seems to play a regulatory role YP_001591395.1 COG: COG2764 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001591396.1 KEGG: eci:UTI89_C4702 8.3e-57 phnA; hypothetical protein PhnA K06193; COG: COG2824 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism; Psort location: nuclear, score: 23 YP_001591397.1 KEGG: cal:orf19.2425 0.00010 highly conserved hypothetical protein K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001591398.1 Psort location: endoplasmic reticulum, score: 9 YP_001591399.1 KEGG: sec:SC4170 3.2e-183 basS, basR; sensory kinase in two-component regulatory system with BasR K07643; COG: COG0642 Signal transduction histidine kinase; Psort location: endoplasmic reticulum, score: 9 YP_001591400.1 response regulator in two-component regulatory system with BasS YP_001591401.1 with ZipA and an unidentified 24 kDa protein forms a complex involved in cell division YP_001591402.1 KEGG: eci:UTI89_C0120 3.8e-18 aroP; aromatic amino acid transport protein AroP K03293; COG: COG0531 Amino acid transporters; Psort location: plasma membrane, score: 23 YP_001591403.1 KEGG: bli:BL05281 2.7e-05 adaA; methylphosphotriester-DNA alkyltransferase and transcriptional regulator (AraC/XylS family) K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: nuclear, score: 23 YP_001591404.1 Psort location: cytoplasmic, score: 23 YP_001591405.1 Psort location: nuclear, score: 23 YP_001591406.1 KEGG: sty:STY4495 0. adi; arginine decarboxylase K01584; COG: COG1982 Arginine/lysine/orniTHIne decarboxylases; Psort location: cytoskeletal, score: 9 YP_001591407.1 KEGG: bha:BH0394 2.0e-11 adaA; methylphosphotriester-DNA alkyltransferase (AraC/XylS family) K00567; COG: COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain; Psort location: cytoplasmic, score: 23 YP_001591408.1 KEGG: stm:STM4298 1.2e-247 melA; alpha-galactosidase K07406; COG: COG1486 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases; Psort location: cytoplasmic, score: 23 YP_001591409.1 KEGG: eci:UTI89_C4210 4.3e-53 yicJ; hypothetical symporter YicJ K03292; COG: COG2211 Na+/melibiose symporter and related transporters; Psort location: plasma membrane, score: 23 YP_001591410.1 KEGG: stt:t4207 1.3e-298 fumB; fumarate hydratase class I K01676; COG: COG1951 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain; Psort location: cytoplasmic, score: 23 YP_001591411.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters YP_001591412.1 Psort location: mitochondrial, score: 23 YP_001591413.1 COG: NOG31352 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001591414.1 Psort location: cytoplasmic, score: 23 YP_001591415.1 response regulator in two-component regulatory system with DcuS; phosphorylated DcuR activates transcription of genes involved in anaerobic fumarate respiration YP_001591416.1 C4-dicarboxylate-sensing histidine kinase; part of two-component regulatory system with DcuR; regulates anaerobic fumarate respiration YP_001591417.1 KEGG: stm:STM4305.S 0. putative anaerobic dimethylsulfoxide reductase subunit A K00397; COG: COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing; Psort location: cytoplasmic, score: 23 YP_001591418.1 KEGG: spt:SPA4124 4.1e-119 dmsB; anaerobic dimethyl sulfoxide reductase subunit B K00397; COG: COG0437 Fe-S-cluster-containing hydrogenase components 1; Psort location: nuclear, score: 23 YP_001591419.1 KEGG: sec:SC4185 1.7e-129 dmsC; putative anaerobic dimethyl sulfoxide reductase, subunit C K00397; COG: COG3302 DMSO reductase anchor subunit; Psort location: plasma membrane, score: 23 YP_001591420.1 KEGG: vfi:VFA0083 4.0e-25 ynfI; anaerobic dimethyl sulfoxide reductase chain YnfI K00397; COG: COG3381 Uncharacterized component of anaerobic dehydrogenases; Psort location: mitochondrial, score: 23 YP_001591421.1 COG: NOG24086 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001591422.1 Psort location: cytoplasmic, score: 23 YP_001591423.1 COG: COG3204 Uncharacterized protein conserved in bacteria; Psort location: mitochondrial, score: 23 YP_001591424.1 COG: NOG27702 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591425.1 KEGG: spz:M5005_Spy_0324 3.3e-09 fhuA; ferrichrome transport ATP-binding protein K02013; COG: COG1120 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components; Psort location: endoplasmic reticulum, score: 9 YP_001591426.1 KEGG: pha:PSHAa1916 0.0015 uvrY, sirA; response regulator K07689; COG: NOG31371 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001591427.1 KEGG: bli:BL05281 2.2e-07 adaA; methylphosphotriester-DNA alkyltransferase and transcriptional regulator (AraC/XylS family) K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: nuclear, score: 23 YP_001591428.1 Psort location: cytoplasmic, score: 23 YP_001591429.1 COG: NOG32347 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001591430.1 Psort location: mitochondrial, score: 23 YP_001591431.1 COG: COG2963 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001591432.1 COG: COG2801 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001591433.1 Psort location: cytoplasmic, score: 23 YP_001591434.1 COG: COG2801 Transposase and inactivated derivatives; Psort location: nuclear, score: 23 YP_001591435.1 Psort location: cytoplasmic, score: 23 YP_001591436.1 COG: NOG06290 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001591437.1 KEGG: spt:SPA4136 7.8e-132 phoN; nonspecific acid phosphatase precursor K01078; COG: COG0671 Membrane-associated phospholipid phosphatase; Psort location: extracellular, including cell wall, score: 9 YP_001591438.1 Psort location: cytoplasmic, score: 23 YP_001591439.1 Psort location: cytoplasmic, score: 23 YP_001591440.1 Psort location: cytoplasmic, score: 23 YP_001591441.1 KEGG: cch:Cag_1803 9.0e-10 ATPase, ParA family K03496; COG: COG1192 ATPases involved in chromosome partitioning; Psort location: cytoplasmic, score: 23 YP_001591442.1 KEGG: plu:plu1031 1.2e-126 unnamed protein product; similar to DNA helicase K02314; COG: COG0305 Replicative DNA helicase; Psort location: cytoplasmic, score: 23 YP_001591443.1 COG: NOG06299 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591444.1 COG: COG1734 DnaK suppressor protein; Psort location: cytoplasmic, score: 23 YP_001591445.1 COG: NOG08737 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591446.1 COG: NOG11459 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001591447.1 Psort location: mitochondrial, score: 23 YP_001591448.1 Psort location: nuclear, score: 23 YP_001591449.1 Psort location: cytoplasmic, score: 23 YP_001591450.1 COG: NOG08740 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001591451.1 Psort location: nuclear, score: 23 YP_001591452.1 COG: NOG07802 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591453.1 decatenates replicating daughter chromosomes YP_001591454.1 Psort location: nuclear, score: 23 YP_001591455.1 COG: NOG13362 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001591456.1 COG: NOG17188 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591457.1 KEGG: shn:Shewana3_3590 1.5e-43 single-strand binding protein K00655; COG: COG0629 Single-stranded DNA-binding protein; Psort location: cytoplasmic, score: 23 YP_001591458.1 COG: NOG16555 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591459.1 KEGG: mgm:Mmc1_0728 0.0011 pyruvate kinase K00873; COG: NOG20290 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591460.1 Psort location: nuclear, score: 23 YP_001591461.1 KEGG: sce:YIR019C 3.1e-06 MUC1; Required for invasion and pseudohyphae formation in response to nitrogen starvation K01178; COG: NOG08741 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001591462.1 COG: NOG14144 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001591463.1 COG: COG1450 Type II secretory pathway, component PulD; Psort location: nuclear, score: 23 YP_001591464.1 COG: NOG08742 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 23 YP_001591465.1 COG: NOG18545 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001591466.1 KEGG: pen:PSEEN2333 5.6e-37 xcpR-2; type II secretion pathway protein E K01509; COG: COG2804 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB; Psort location: cytoplasmic, score: 23 YP_001591467.1 COG: COG1459 Type II secretory pathway, component PulF; Psort location: plasma membrane, score: 23 YP_001591468.1 COG: NOG11462 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001591469.1 KEGG: cpe:CPE1992 9.2e-05 probable soluble lytic transglycosylase K01238; COG: COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains); Psort location: extracellular, including cell wall, score: 9 YP_001591470.1 KEGG: ava:Ava_2985 1.5e-10 peptidase A24A, prepilin type IV K02654; COG: NOG14146 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001591471.1 KEGG: cal:orf19.4072 0.00059 HYR10; similar to cell surface flocculin K01186; COG: NOG07919 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001591472.1 Psort location: cytoplasmic, score: 23 YP_001591473.1 COG: COG0582 Integrase; Psort location: nuclear, score: 23 YP_001591474.1 Psort location: cytoplasmic, score: 23 YP_001591475.1 COG: NOG14148 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001591476.1 COG: NOG08743 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001591477.1 COG: COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains); Psort location: extracellular, including cell wall, score: 9 YP_001591478.1 COG: NOG13628 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001591479.1 COG: COG1715 Restriction endonuclease; Psort location: mitochondrial, score: 23 YP_001591480.1 Psort location: endoplasmic reticulum, score: 9 YP_001591481.1 COG: NOG06089 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591482.1 COG: NOG08744 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001591483.1 Psort location: nuclear, score: 23 YP_001591484.1 COG: NOG17699 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001591485.1 Psort location: extracellular, including cell wall, score: 23 YP_001591486.1 COG: NOG17700 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001591487.1 COG: NOG17701 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001591488.1 COG: NOG07920 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001591489.1 COG: NOG07921 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001591490.1 KEGG: cal:orf19.4072 2.3e-06 HYR10; similar to cell surface flocculin K01186; COG: NOG06300 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001591491.1 Psort location: cytoplasmic, score: 23 YP_001591492.1 COG: NOG14028 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001591493.1 COG: NOG06090 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591494.1 Psort location: cytoplasmic, score: 23 YP_001591495.1 COG: NOG18547 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591496.1 COG: NOG17702 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001591497.1 COG: NOG06091 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001591498.1 COG: NOG06092 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001591499.1 COG: NOG14946 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001591500.1 COG: NOG06088 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001591501.1 Psort location: nuclear, score: 23 YP_001591502.1 Psort location: endoplasmic reticulum, score: 9 YP_001591503.1 KEGG: azo:azo0200 0.0015 sbcC; exonuclease SbcC, putative K01146; COG: NOG17142 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591504.1 Psort location: cytoplasmic, score: 23 YP_001591505.1 COG: NOG23032 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591506.1 Psort location: cytoplasmic, score: 23 YP_001591507.1 Psort location: endoplasmic reticulum, score: 9 YP_001591508.1 Psort location: cytoplasmic, score: 23 YP_001591509.1 Psort location: mitochondrial, score: 23 YP_001591510.1 COG: NOG06093 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591511.1 COG: COG0433 Predicted ATPase; Psort location: cytoplasmic, score: 23 YP_001591512.1 COG: NOG16065 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591513.1 Psort location: cytoplasmic, score: 23 YP_001591514.1 KEGG: ape:APE_2290.1 0.0042 acylamino-acid-releasing enzyme K01303; Psort location: endoplasmic reticulum, score: 9 YP_001591515.1 KEGG: rde:RD1_2397 1.2e-08 arsC; arsenate reductase, putative; COG: COG0640 Predicted transcriptional regulators; Psort location: nuclear, score: 23 YP_001591516.1 KEGG: cya:CYA_1496 2.8e-17 NADPH-dependent FMN reductase K00299; COG: COG0431 Predicted flavoprotein; Psort location: cytoplasmic, score: 23 YP_001591517.1 KEGG: btl:BALH_3229 0.00068 sigW; RNA polymerase sigma-70 factor, ECF subfamily K00960; COG: COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Psort location: nuclear, score: 23 YP_001591518.1 COG: NOG16890 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001591519.1 KEGG: mfa:Mfla_1491 4.8e-196 arsenite-activated ATPase (ArsA) K01551; COG: COG0003 Oxyanion-translocating ATPase; Psort location: cytoplasmic, score: 23 YP_001591520.1 COG: COG2005 N-terminal domain of molybdenum-binding protein; Psort location: mitochondrial, score: 23 YP_001591521.1 COG: NOG08651 non supervised orthologous group; Psort location: plasma membrane, score: 23 YP_001591522.1 KEGG: eca:ECA0956 6.7e-55 putative acetyltransferase K03823; COG: COG1247 Sortase and related acyltransferases; Psort location: cytoplasmic, score: 23 YP_001591523.1 KEGG: mka:MK1013 0.0067 ntpK; archaeal/vacuolar-type H+-ATPase subunit K K02124; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001591524.1 KEGG: azo:azo2351 6.3e-43 arsC1; putative arsenate reductase (glutaredoxin); COG: COG0394 Protein-tyrosine-phosphatase; Psort location: extracellular, including cell wall, score: 9 YP_001591525.1 KEGG: ecj:JW3470 4.7e-63 arsC; arsenate reductase K00537; COG: COG1393 Arsenate reductase and related proteins, glutaredoxin family; Psort location: cytoplasmic, score: 23 YP_001591526.1 KEGG: ecj:JW3469 1.6e-211 arsB; arsenite/antimonite transporter K03893; COG: COG1055 Na+/H+ antiporter NhaD and related arsenite permeases; Psort location: plasma membrane, score: 23 YP_001591527.1 KEGG: mfa:Mfla_1491 1.2e-208 arsenite-activated ATPase (ArsA) K01551; COG: COG0003 Oxyanion-translocating ATPase; Psort location: cytoplasmic, score: 23 YP_001591528.1 COG: NOG18908 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591529.1 COG: NOG16890 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591530.1 COG: COG0640 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001591531.1 COG: COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair; Psort location: cytoplasmic, score: 23 YP_001591532.1 COG: NOG11463 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591533.1 Psort location: mitochondrial, score: 23 YP_001591534.1 Psort location: cytoplasmic, score: 23 YP_001591535.1 COG: COG0582 Integrase; Psort location: nuclear, score: 23 YP_001591536.1 Psort location: cytoplasmic, score: 23 YP_001591537.1 Psort location: cytoplasmic, score: 23 YP_001591538.1 Psort location: extracellular, including cell wall, score: 9 YP_001591539.1 Psort location: cytoplasmic, score: 23 YP_001591540.1 COG: NOG27027 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001591541.1 Psort location: nuclear, score: 23 YP_001591542.1 KEGG: vfi:VFB02 1.9e-57 traC; DNA primase TraC; COG: COG4227 Antirestriction protein; Psort location: mitochondrial, score: 23 YP_001591543.1 COG: NOG11315 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591544.1 KEGG: hal:VNG0106G 9.2e-06 rmeM; type I restriction modification enzyme, M subunit K03427; COG: NOG31012 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591545.1 COG: COG1943 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001591546.1 Psort location: cytoplasmic, score: 23 YP_001591547.1 Psort location: cytoplasmic, score: 23 YP_001591548.1 Psort location: cytoplasmic, score: 23 YP_001591549.1 Psort location: extracellular, including cell wall, score: 9 YP_001591550.1 COG: NOG11280 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591551.1 Psort location: cytoplasmic, score: 23 YP_001591552.1 COG: NOG11463 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591553.1 Psort location: cytoplasmic, score: 23 YP_001591554.1 COG: NOG08745 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591555.1 COG: COG0582 Integrase; Psort location: cytoplasmic, score: 23 YP_001591556.1 COG: COG1309 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001591557.1 two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm YP_001591558.1 copper binding protein required for copper tolerance; involved in resistance toward heavy metals YP_001591559.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB YP_001591560.1 catalyzes the formation of fumarate from aspartate YP_001591561.1 F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein YP_001591562.1 uncharacterized member of the APC superfamily of amino acid transporters; unknown function YP_001591563.1 KEGG: ftu:FTT1695 3.2e-23 groS, htpA; chaperonin protein, groES K04078; COG: COG0234 Co-chaperonin GroES (HSP10); Psort location: cytoplasmic, score: 23 YP_001591564.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_001591565.1 Psort location: cytoplasmic, score: 23 YP_001591566.1 COG: NOG09783 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001591567.1 COG: NOG06800 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001591568.1 Psort location: nuclear, score: 23 YP_001591569.1 KEGG: eci:UTI89_C4744 3.9e-162 yjeK; hypothetical protein YjeK K01843; COG: COG1509 Lysine 2,3-aminomutase; Psort location: cytoplasmic, score: 23 YP_001591570.1 KEGG: fth:FTH_0176 1.8e-54 efp; protein-synthesizing GTPase; COG: COG0231 Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A); Psort location: cytoplasmic, score: 23 YP_001591571.1 COG: COG5510 Predicted small secreted protein; Psort location: mitochondrial, score: 23 YP_001591572.1 KEGG: ava:Ava_2028 1.3e-05 two component transcriptional regulator, LuxR family; COG: COG2771 DNA-binding HTH domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001591573.1 Psort location: nuclear, score: 23 YP_001591574.1 member of the SMR family of proton-dependent drug efflux transporters; quaternary ammonium compound efflux pump; confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations YP_001591575.1 lipocalin; globomycin-sensitive outer membrane lipoprotein YP_001591576.1 in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane YP_001591577.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB YP_001591578.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB YP_001591579.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB YP_001591580.1 lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_001591581.1 Psort location: cytoplasmic, score: 23 YP_001591582.1 KEGG: eci:UTI89_C0120 0.00047 aroP; aromatic amino acid transport protein AroP K03293; COG: COG0531 Amino acid transporters; Psort location: plasma membrane, score: 23 YP_001591583.1 Psort location: cytoplasmic, score: 23 YP_001591584.1 COG: NOG23104 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591585.1 KEGG: rno:113960 1.4e-10 Cdc42bpb; Cdc42 binding protein kinase beta K08286; COG: COG3264 Small-conductance mechanosensitive channel; Psort location: plasma membrane, score: 23 YP_001591586.1 catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine YP_001591587.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity YP_001591588.1 3'-5' exoribonuclease specific for small oligoribonuclotides YP_001591589.1 KEGG: eci:UTI89_C2121 1.7e-26 fliY; cystine-binding periplasmic protein precursor K02030:K02424; COG: COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain; Psort location: vacuolar, score: 9 YP_001591590.1 COG: COG1600 Uncharacterized Fe-S protein; Psort location: cytoplasmic, score: 23 YP_001591591.1 KEGG: reh:H16_A1504 1.3e-67 predicted sugar kinase K00924; COG: COG0063 Predicted sugar kinase; Psort location: cytoplasmic, score: 23 YP_001591592.1 possibly involved in cell wall synthesis YP_001591593.1 KEGG: stm:STM4358 1.6e-229 amiB; N-acetylmuramoyl-l-alanine amidase II, a murein hydrolase K01448; COG: COG0860 N-acetylmuramoyl-L-alanine amidase; Psort location: extracellular, including cell wall, score: 9 YP_001591594.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex YP_001591595.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_001591596.1 Stimulates the elongation of poly(A) tails YP_001591597.1 involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein YP_001591598.1 with HflC inhibits proteolysis of lambda cII protein by FtsH YP_001591599.1 with HflK inhibits proteolysis of lambda cII protein by FtsH YP_001591600.1 COG: COG3242 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001591601.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_001591602.1 negatively regulates the transcription of genes upregulated by nitrosative stress YP_001591603.1 3'-5'exoribonuclease that acts nonspecifically on poly(A), poly(U) and ribosomal RNAs YP_001591604.1 Psort location: nuclear, score: 23 YP_001591605.1 Specifically methylates the ribose of guanosine 2251 in 23S rRNA YP_001591606.1 COG: COG3789 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001591607.1 KEGG: eci:UTI89_C0735 0.0035 tolA; membrane spanning protein TolA K03646; COG: COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription; Psort location: cytoplasmic, score: 23 YP_001591608.1 COG: COG1226 Kef-type K+ transport systems, predicted NAD-binding component; Psort location: golgi, score: 9 YP_001591609.1 COG: NOG07922 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591610.1 COG: COG3766 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001591611.1 COG: COG5463 Predicted integral membrane protein; Psort location: mitochondrial, score: 23 YP_001591612.1 KEGG: vvy:VV2267 3.0e-100 glutaTHIonylspermidine synthase K01917; COG: COG0754 GlutaTHIonylspermidine synthase; Psort location: cytoplasmic, score: 23 YP_001591613.1 catalyzes the formation of 3-methylcrotonyl-CoA from isovaleryl-CoA YP_001591614.1 COG: NOG11343 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001591615.1 in Escherichia coli, mutation of this gene affects biofilm maturation, stress response, and motility YP_001591616.1 YjfP; esterase activity towards palmitoyl-CoA and pNP-butyrate in vitro; unknown function and substrate in vivo YP_001591617.1 negative regulator of ulaG and ulaABCDEF YP_001591618.1 KEGG: spi:MGAS10750_Spy0162 7.6e-118 metal-dependent hydrolase; COG: COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold; Psort location: extracellular, including cell wall, score: 9 YP_001591619.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr YP_001591620.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake YP_001591621.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake YP_001591622.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization YP_001591623.1 UlaE; catalyzes the epimerization of L-ribulose-5-phosphate into L-xylulose-5-phosphate; part of the anaerobic L-ascorbate degradation pathway YP_001591624.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source YP_001591625.1 COG: NOG11317 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001591626.1 Psort location: mitochondrial, score: 23 YP_001591627.1 COG: NOG35248 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591628.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_001591629.1 COG: COG2965 Primosomal replication protein N; Psort location: cytoplasmic, score: 23 YP_001591630.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_001591631.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_001591632.1 COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: endoplasmic reticulum, score: 9 YP_001591633.1 KEGG: pen:PSEEN0463 2.1e-06 peptidase, M23/M37 family K01423; COG: COG3061 Cell envelope opacity-associated protein A; Psort location: nuclear, score: 23 YP_001591634.1 FKBP-type; rotamase; catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides YP_001591635.1 involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine YP_001591636.1 Psort location: mitochondrial, score: 23 YP_001591637.1 COG: NOG26648 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001591638.1 COG: NOG26001 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001591639.1 Involved in anaerobic NO protection and iron metabolism YP_001591640.1 KEGG: reh:H16_A3257 0.00011 pilD; type IV pilus prepilin leader peptidase 1; COG: COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily; Psort location: plasma membrane, score: 23 YP_001591641.1 KEGG: eci:UTI89_C4820 1.5e-112 ytfG; hypothetical protein YtfG; COG: COG0702 Predicted nucleoside-diphosphate-sugar epimerases; Psort location: cytoplasmic, score: 23 YP_001591642.1 COG: COG1733 Predicted transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001591643.1 periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate YP_001591644.1 Psort location: cytoplasmic, score: 23 YP_001591645.1 catalyzes the formation of AMP from adenosine-3',5'-bisphosphate YP_001591646.1 COG: COG3054 Predicted transcriptional regulator; Psort location: extracellular, including cell wall, score: 9 YP_001591647.1 Psort location: mitochondrial, score: 23 YP_001591648.1 COG: NOG17567 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001591649.1 KEGG: hpa:HPAG1_1423 9.3e-42 putative integral membrane protein with a TlyC-like hemolysin domain K00088; COG: COG1253 Hemolysins and related proteins containing CBS domains; Psort location: endoplasmic reticulum, score: 9 YP_001591650.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress YP_001591651.1 Psort location: endoplasmic reticulum, score: 9 YP_001591652.1 COG: COG0729 Outer membrane protein; Psort location: extracellular, including cell wall, score: 9 YP_001591653.1 KEGG: bme:BMEI1894 5.3e-11 gramicidin S biosynthesis GrsT protein K01076; COG: COG2911 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001591654.1 COG: COG2105 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001591655.1 KEGG: bpm:BURPS1710b_1865 0.0041 acyltransferase family protein K00655; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001591656.1 KEGG: bcl:ABC1407 2.5e-55 dihydroorotase K01465; COG: COG3964 Predicted amidohydrolase; Psort location: cytoplasmic, score: 23 YP_001591657.1 catalyzes the hydrolysis of pyrophosphate to phosphate YP_001591658.1 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate YP_001591659.1 Psort location: cytoplasmic, score: 23 YP_001591660.1 KEGG: stm:STM4416 4.6e-253 mpl; UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase K02558; COG: COG0773 UDP-N-acetylmuramate-alanine ligase; Psort location: extracellular, including cell wall, score: 9 YP_001591661.1 Psort location: cytoplasmic, score: 23 YP_001591662.1 Psort location: nuclear, score: 23 YP_001591663.1 KEGG: bxe:Bxe_A3454 2.7e-10 glucokinase K00845; COG: COG1737 Transcriptional regulators; Psort location: cytoplasmic, score: 23 YP_001591664.1 KEGG: cal:orf19.644 2.5e-41 HXT4; high-affinity glucose transporter or sensor K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001591665.1 Psort location: cytoplasmic, score: 23 YP_001591666.1 KEGG: cal:orf19.4356 9.5e-40 HGT3; high-affinity glucose transporter K01804; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001591667.1 Psort location: nuclear, score: 23 YP_001591668.1 COG: COG3718 Uncharacterized enzyme involved in inositol metabolism; Psort location: cytoplasmic, score: 23 YP_001591669.1 KEGG: stm:STM4421 1.6e-268 putative NAD-dependent aldehyde dehydrogenase K00140; COG: COG1012 NAD-dependent aldehyde dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001591670.1 Psort location: nuclear, score: 23 YP_001591671.1 KEGG: bha:BH0394 4.7e-15 adaA; methylphosphotriester-DNA alkyltransferase (AraC/XylS family) K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001591672.1 Psort location: extracellular, including cell wall, score: 9 YP_001591673.1 KEGG: hne:HNE_2184 8.5e-48 iolE; 2-keto-myo-inositol dehydratase K01726; COG: COG1082 Sugar phosphate isomerases/epimerases; Psort location: extracellular, including cell wall, score: 9 YP_001591674.1 KEGG: stm:STM4425 7.8e-180 putative myo-inositol 2-dehydrogenase K00010; COG: COG0673 Predicted dehydrogenases and related proteins; Psort location: cytoplasmic, score: 23 YP_001591675.1 KEGG: stm:STM4426 1.7e-248 srfJ; activated by transcription factor SsrB, similar to Homo sapiens lysosomal glucosyl ceramidase K01201; COG: COG5520 O-Glycosyl hydrolase; Psort location: cytoplasmic, score: 23 YP_001591676.1 KEGG: reu:Reut_B5035 5.4e-13 4-hydroxyphenylpyruvate dioxygenase K00457; COG: COG1082 Sugar phosphate isomerases/epimerases; Psort location: cytoplasmic, score: 23 YP_001591677.1 KEGG: bja:bll2324 0.0036 long-chain-fatty-acid--[acyl-carrier-protein] ligase / acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase K05939:K01909; COG: NOG06005 non supervised orthologous group; Psort location: plasma membrane, score: 23 YP_001591678.1 KEGG: bpm:BURPS1710b_1831 3.3e-181 iolC; IolC protein K03338; COG: COG0524 Sugar kinases, ribokinase family; Psort location: cytoplasmic, score: 23 YP_001591679.1 Psort location: vesicles of secretory system, score: 9 YP_001591680.1 Psort location: cytoplasmic, score: 23 YP_001591681.1 Psort location: cytoplasmic, score: 23 YP_001591682.1 KEGG: pst:PSPTO_3495 9.1e-241 iolD protein K03336; COG: COG3962 Acetolactate synthase; Psort location: cytoplasmic, score: 23 YP_001591683.1 Psort location: cytoplasmic, score: 23 YP_001591684.1 KEGG: lpl:lp_3612 6.8e-110 iolG4; myo-inositol 2-dehydrogenase K00010; COG: COG0673 Predicted dehydrogenases and related proteins; Psort location: cytoplasmic, score: 23 YP_001591685.1 COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001591686.1 COG: COG4130 Predicted sugar epimerase; Psort location: cytoplasmic, score: 23 YP_001591687.1 KEGG: vvy:VVA1609 0.0059 putative L-xylulose-5-phosphate 3-epimerase K03079; COG: COG1082 Sugar phosphate isomerases/epimerases; Psort location: cytoplasmic, score: 23 YP_001591688.1 COG: COG3028 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001591689.1 protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD YP_001591690.1 KEGG: eco:b4236 1.9e-41 cybC; cytochrome b562, truncated (pseudogene); COG: COG3783 Soluble cytochrome b562; Psort location: extracellular, including cell wall, score: 9 YP_001591691.1 Psort location: mitochondrial, score: 23 YP_001591692.1 KEGG: stm:STM4006 0.0092 glnL; sensory kinase (phosphatase) in two-component regulatory system with GlnG (nitrogen regulator II, NRII) K07708; COG: NOG18554 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591693.1 COG: NOG11467 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591694.1 COG: NOG18555 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591695.1 COG: NOG07923 non supervised orthologous group; Psort location: plasma membrane, score: 23 YP_001591696.1 COG: NOG08746 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001591697.1 Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides YP_001591698.1 KEGG: efa:EF0838 2.5e-96 pyridoxal phosphate-dependent enzyme, putative K01042; COG: COG1921 Selenocysteine synthase [seryl-tRNASer selenium transferase]; Psort location: cytoplasmic, score: 23 YP_001591699.1 COG: NOG08125 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591700.1 KEGG: spk:MGAS9429_Spy1126 1.3e-30 PTS system, mannitol (cryptic)-specific IIA component K00890; COG: COG3711 Transcriptional antiterminator; Psort location: cytoplasmic, score: 23 YP_001591701.1 Qin prophage; bifunctional antitoxin of the RelE-RelB toxin-antitoxin system/transcriptional repressor YP_001591702.1 COG: COG2026 Cytotoxic translational repressor of toxin-antitoxin stability system; Psort location: cytoplasmic, score: 23 YP_001591703.1 KEGG: stm:STM4451 1.1e-68 nrdG; anaerobic ribonucleotide reductase activating protein K04068; COG: COG0602 Organic radical activating enzymes; Psort location: cytoplasmic, score: 23 YP_001591704.1 Psort location: nuclear, score: 23 YP_001591705.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates YP_001591706.1 COG: NOG35849 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001591707.1 KEGG: spt:SPA4254 0. treC; trehalose-6-phosphate hydrolase K01226; COG: COG0366 Glycosidases; Psort location: cytoplasmic, score: 23 YP_001591708.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_001591709.1 Psort location: cytoplasmic, score: 23 YP_001591710.1 regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon YP_001591711.1 Psort location: mitochondrial, score: 23 YP_001591712.1 P-type ATPase involved in magnesium influx YP_001591713.1 COG: NOG23020 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591714.1 KEGG: ape:APE_1501.1 6.8e-23 ribonuclease UK114; COG: COG0251 Putative translation initiation inhibitor, yjgF family; Psort location: cytoplasmic, score: 23 YP_001591715.1 involved in the allosteric regulation of aspartate carbamoyltransferase YP_001591716.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_001591717.1 COG: COG1438 Arginine repressor; Psort location: cytoplasmic, score: 23 YP_001591718.1 Psort location: mitochondrial, score: 23 YP_001591719.1 Psort location: endoplasmic reticulum, score: 9 YP_001591720.1 COG: COG1288 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001591721.1 catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway YP_001591722.1 Psort location: nuclear, score: 23 YP_001591723.1 reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP YP_001591724.1 catalyzes the degradation of arginine to citruline and ammonia YP_001591725.1 Psort location: endoplasmic reticulum, score: 9 YP_001591726.1 Psort location: golgi, score: 9 YP_001591727.1 KEGG: aci:ACIAD3226 0.0045 putative flavohemoprotein (hemoglobin-like protein) (flavohemoglobin) K00357; COG: COG2731 Beta-galactosidase, beta subunit; Psort location: cytoplasmic, score: 23 YP_001591728.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; E. coli K12 has two genes, argF and argI, capable of producing functional ornithine carbamoyltransferase. When both are active in the same cell, the two gene products form a family of four hybrid trimeric isoenzymes designated, FFF, FFI, FII, and III. YP_001591729.1 COG: COG3076 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001591730.1 KEGG: stm:STM4471 1.4e-143 miaE; hydroxylase for synthesis of 2-methylTHIo-cis-ribozeatin in tRNA K06169; COG: COG4445 Hydroxylase for synthesis of 2-methylTHIo-cis-ribozeatin in tRNA; Psort location: mitochondrial, score: 23 YP_001591731.1 COG: NOG32839 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591732.1 COG: NOG27048 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001591733.1 KEGG: stm:STM4473 2.5e-87 yjgM; putative acetyltransferase K03828; COG: COG0454 Histone acetyltransferase HPA2 and related acetyltransferases; Psort location: mitochondrial, score: 23 YP_001591734.1 COG: COG4269 Predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001591735.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_001591736.1 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB YP_001591737.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides YP_001591738.1 COG: COG0795 Predicted permeases; Psort location: endoplasmic reticulum, score: 9 YP_001591739.1 COG: COG0795 Predicted permeases; Psort location: endoplasmic reticulum, score: 9 YP_001591740.1 KEGG: efa:EF1922 3.6e-09 transcriptional regulator, LacI family/carbohydrate kinase, PfkB family protein K00852; COG: COG1609 Transcriptional regulators; Psort location: nuclear, score: 23 YP_001591741.1 KEGG: eci:UTI89_C3106 1.5e-64 ygbN; hypothetical permease YgbN K03299; COG: COG2610 H+/gluconate symporter and related permeases; Psort location: plasma membrane, score: 23 YP_001591742.1 Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate YP_001591743.1 NAD-binding YP_001591744.1 Psort location: cytoplasmic, score: 23 YP_001591745.1 KEGG: stm:STM4485 4.3e-92 idnK; thermosensitive D-gluconate kinase K00851; COG: COG3265 Gluconate kinase; Psort location: nuclear, score: 23 YP_001591746.1 KEGG: eci:UTI89_C4876 6.2e-171 yjgB; putative oxidoreductase K00100; COG: COG1064 Zn-dependent alcohol dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001591747.1 Psort location: nuclear, score: 23 YP_001591748.1 COG: COG3335 Transposase and inactivated derivatives; Psort location: cytoplasmic, score: 23 YP_001591749.1 COG: NOG18109 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591750.1 COG: COG5302 Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid; Psort location: cytoplasmic, score: 23 YP_001591751.1 COG: NOG18222 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591752.1 COG: COG0582 Integrase; Psort location: nuclear, score: 23 YP_001591753.1 KEGG: chu:CHU_1556 8.8e-11 DNA helicase K01529; COG: COG1112 Superfamily I DNA and RNA helicases and helicase subunits; Psort location: nuclear, score: 23 YP_001591754.1 KEGG: plu:plu0338 1.2e-192 dcm; DNA-cytosine methyltransferase K00558; COG: COG0270 Site-specific DNA methylase; Psort location: cytoplasmic, score: 23 YP_001591755.1 KEGG: nme:NMB1289 2.1e-51 type II restriction enzyme, putative K01155; COG: NOG14036 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591756.1 COG: COG3177 Uncharacterized conserved protein; Psort location: mitochondrial, score: 23 YP_001591757.1 KEGG: zmo:ZMO0153 4.6e-40 yebC; glucose-1-phosphate adenylyl transferase K00975; COG: COG0217 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001591758.1 KEGG: sat:SYN_00463 3.8e-36 methyltransferase K00599; COG: COG0500 SAM-dependent methyltransferases; Psort location: cytoplasmic, score: 23 YP_001591759.1 Psort location: mitochondrial, score: 23 YP_001591760.1 KEGG: eci:UTI89_C3253 0.0024 xanTHIne dehydrogenase iron-sulfur binding subunit K00190; COG: COG3811 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001591761.1 Psort location: cytoplasmic, score: 23 YP_001591762.1 COG: COG4332 Uncharacterized protein conserved in bacteria; Psort location: mitochondrial, score: 23 YP_001591763.1 COG: NOG18152 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591764.1 COG: NOG08605 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591765.1 Psort location: nuclear, score: 23 YP_001591766.1 Psort location: cytoplasmic, score: 23 YP_001591767.1 COG: COG3439 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001591768.1 KEGG: rfr:Rfer_3810 3.3e-09 carboxymethylenebutenolidase K01061; COG: COG0412 Dienelactone hydrolase and related enzymes; Psort location: cytoplasmic, score: 23 YP_001591769.1 Psort location: cytoplasmic, score: 23 YP_001591770.1 Psort location: cytoplasmic, score: 23 YP_001591771.1 regulates the expression of uxuBA YP_001591772.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001591773.1 COG: NOG34393 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591774.1 COG: COG3157 Hemolysin-coregulated protein (uncharacterized); Psort location: cytoplasmic, score: 23 YP_001591775.1 Psort location: mitochondrial, score: 23 YP_001591776.1 KEGG: eca:ECA1500 2.4e-50 probable aspartate racemase K01779; COG: COG1794 Aspartate racemase; Psort location: cytoplasmic, score: 23 YP_001591777.1 KEGG: shn:Shewana3_3435 4.9e-12 transcriptional regulator, LysR family K06022; COG: COG0583 Transcriptional regulator; Psort location: cytoplasmic, score: 23 YP_001591778.1 KEGG: spt:SPA4332 1.1e-203 iadA; probable isoaspartyl dipeptidase K01305; COG: NOG06797 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591779.1 COG: COG0700 Uncharacterized membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001591780.1 COG: COG3314 Uncharacterized protein conserved in bacteria; Psort location: endoplasmic reticulum, score: 9 YP_001591781.1 COG: COG3314 Uncharacterized protein conserved in bacteria; Psort location: mitochondrial, score: 23 YP_001591782.1 KEGG: eci:UTI89_C5041 1.4e-148 yjiJ; hypothetical protein YjiJ K00403; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001591783.1 Psort location: cytoplasmic, score: 23 YP_001591784.1 COG: COG2733 Predicted membrane protein; Psort location: endoplasmic reticulum, score: 9 YP_001591785.1 KEGG: shn:Shewana3_1692 0.00070 Xaa-His dipeptidase K01270; COG: COG0477 Permeases of the major facilitator superfamily; Psort location: plasma membrane, score: 23 YP_001591786.1 Psort location: cytoplasmic, score: 23 YP_001591787.1 Psort location: nuclear, score: 23 YP_001591788.1 COG: COG5464 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001591789.1 Psort location: cytoplasmic, score: 23 YP_001591790.1 KEGG: spt:SPA4340 9.1e-241 putative NAD-dependent aldehyde dehydrogenase K00135; COG: COG1012 NAD-dependent aldehyde dehydrogenases; Psort location: cytoplasmic, score: 23 YP_001591791.1 COG: COG5457 Uncharacterized conserved small protein; Psort location: cytoplasmic, score: 23 YP_001591792.1 COG: NOG26728 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001591793.1 involved in the degradation of RNA; may be involved in the recycling of RNA during the SOS response YP_001591794.1 specificity determinant for hsdM and hsdR YP_001591795.1 KEGG: stm:STM4525 3.9e-281 hsdM; DNA methylase M, host modification K03427; COG: COG0286 Type I restriction-modification system methyltransferase subunit; Psort location: cytoplasmic, score: 23 YP_001591796.1 restriction endonuclease; the EcoKI enzyme recognizes 5'-AACN(6)GTGC-3'; subunit R is required for both nuclease and ATPase activities YP_001591797.1 COG: COG1715 Restriction endonuclease; Psort location: cytoplasmic, score: 23 YP_001591798.1 Psort location: cytoplasmic, score: 23 YP_001591799.1 COG: COG2929 Uncharacterized protein conserved in bacteria; Psort location: cytoplasmic, score: 23 YP_001591800.1 KEGG: cdi:DIP1558 0.0095 hisF; imidazole glycerol phosphate synthase subunit K02500; COG: COG3514 Uncharacterized protein conserved in bacteria; Psort location: nuclear, score: 23 YP_001591801.1 KEGG: reh:H16_A0195 1.6e-60 putative GTPase (G3E family); COG: COG0523 Putative GTPases (G3E family); Psort location: cytoplasmic, score: 23 YP_001591802.1 COG: COG2879 Uncharacterized small protein; Psort location: cytoplasmic, score: 23 YP_001591803.1 COG: COG1966 Carbon starvation protein, predicted membrane protein; Psort location: plasma membrane, score: 23 YP_001591804.1 Psort location: cytoplasmic, score: 23 YP_001591805.1 KEGG: syn:sll1871 2.4e-07 hik6; two-component sensor histidine kinase K02486; COG: COG0840 Methyl-accepting chemotaxis protein; Psort location: endoplasmic reticulum, score: 9 YP_001591806.1 Psort location: mitochondrial, score: 23 YP_001591807.1 KEGG: reh:H16_A2683 5.5e-28 response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K01529; COG: COG3933 Transcriptional antiterminator; Psort location: cytoplasmic, score: 23 YP_001591808.1 KEGG: sec:SC4387 1.8e-70 putative PTS permease K02793; COG: COG2893 Phosphotransferase system, mannose/fructose-specific component IIA; Psort location: cytoplasmic, score: 23 YP_001591809.1 KEGG: sec:SC4388 2.4e-75 ptrB; putative PTS permease K02794; COG: COG3444 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB; Psort location: cytoplasmic, score: 23 YP_001591810.1 KEGG: lsl:LSL_1715 5.2e-32 PTS system, mannose-specific IIC component K00890; COG: COG3715 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC; Psort location: endoplasmic reticulum, score: 9 YP_001591811.1 KEGG: hso:HS_0607 5.3e-55 manZ; protein-N(pi)-phosphohistidine-sugar phosphotransferase (mannose-specific phosphotransferase system IID component) K02796; COG: COG3716 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID; Psort location: plasma membrane, score: 23 YP_001591812.1 KEGG: lwe:lwe2019 1.8e-52 glucosamine--fructose-6-phosphate aminotransferase , putative K00820; COG: COG0449 Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains; Psort location: endoplasmic reticulum, score: 9 YP_001591813.1 KEGG: lwe:lwe2018 2.6e-46 sugar isomerase domain protein; COG: COG2222 Predicted phosphosugar isomerases; Psort location: cytoplasmic, score: 23 YP_001591814.1 Psort location: nuclear, score: 23 YP_001591815.1 catalyzes the transfer of phosphoglycerol to the glucan backbone YP_001591816.1 Psort location: mitochondrial, score: 23 YP_001591817.1 COG: NOG12172 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 9 YP_001591818.1 acts to load the DnaB helicase onto the initiation site during DNA replication YP_001591819.1 This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' YP_001591820.1 COG: COG3610 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001591821.1 COG: COG2966 Uncharacterized conserved protein; Psort location: endoplasmic reticulum, score: 9 YP_001591822.1 Psort location: cytoskeletal, score: 9 YP_001591823.1 COG: NOG09075 non supervised orthologous group; Psort location: nuclear, score: 23 YP_001591824.1 regulator for the transport and utilization of the aromatic beta-glucosides arbutin and silicin YP_001591825.1 KEGG: bcl:ABC2234 2.2e-08 proS, pro; prolyl-tRNA synthetase K01881; COG: COG2606 Uncharacterized conserved protein; Psort location: cytoplasmic, score: 23 YP_001591826.1 KEGG: gbe:GbCGDNIH1_2380 1.1e-05 ferric hydroxamate reductase FhuF K00521; COG: COG4114 Uncharacterized Fe-S protein; Psort location: cytoplasmic, score: 23 YP_001591827.1 KEGG: syn:sll1687 2.2e-25 hik17; hypothetical protein; COG: COG2199 FOG: GGDEF domain; Psort location: endoplasmic reticulum, score: 9 YP_001591828.1 Psort location: mitochondrial, score: 23 YP_001591829.1 COG: NOG09784 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001591830.1 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit YP_001591831.1 Psort location: nuclear, score: 23 YP_001591832.1 with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB YP_001591833.1 KEGG: stt:t4601 9.7e-47 rimI; ribosomal-protein-alanine acetyltransferase K03789; COG: COG0456 Acetyltransferases; Psort location: cytoplasmic, score: 23 YP_001591834.1 manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily YP_001591835.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein YP_001591836.1 Psort location: cytoplasmic, score: 23 YP_001591837.1 KEGG: hit:NTHI0707 0.00029 fkbY; probable FKBP-type peptidyl-prolyl cis-trans isomerase K03772; COG: COG2823 Predicted periplasmic or secreted lipoprotein; Psort location: extracellular, including cell wall, score: 9 YP_001591838.1 COG: NOG16919 non supervised orthologous group; Psort location: extracellular, including cell wall, score: 23 YP_001591839.1 Psort location: endoplasmic reticulum, score: 9 YP_001591840.1 KEGG: vfi:VFA0008 3.3e-37 phospholipase; COG: COG4667 Predicted esterase of the alpha-beta hydrolase superfamily; Psort location: cytoplasmic, score: 23 YP_001591841.1 KEGG: sec:SC4412 1.5e-135 yjjV; putative hydrolase K03424; COG: COG0084 Mg-dependent DNase; Psort location: cytoplasmic, score: 23 YP_001591842.1 KEGG: vfi:VFA0962 8.3e-73 pyruvate formate-lyase activating enzyme K04069; COG: COG1180 Pyruvate-formate lyase-activating enzyme; Psort location: cytoplasmic, score: 23 YP_001591843.1 COG: NOG06143 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001591844.1 Psort location: cytoplasmic, score: 23 YP_001591845.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate YP_001591846.1 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate YP_001591847.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose YP_001591848.1 Psort location: cytoplasmic, score: 23 YP_001591849.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate YP_001591850.1 Psort location: nuclear, score: 23 YP_001591851.1 COG: NOG10251 non supervised orthologous group; Psort location: endoplasmic reticulum, score: 9 YP_001591852.1 Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl on the lipoate-dependent enzymes. Creates an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoyl domain of apoproteins YP_001591853.1 KEGG: ece:Z5988 2.1e-99 putative lipoate-protein ligase A K03800:K07186; COG: COG3726 Uncharacterized membrane protein affecting hemolysin expression; Psort location: endoplasmic reticulum, score: 9 YP_001591854.1 catalyzes the formation of serine from O-phosphoserine YP_001591855.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_001591856.1 catalyzes the formation of NAD(+) from nicotinamide ribonucleotide YP_001591857.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence YP_001591858.1 catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan YP_001591859.1 When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription YP_001591860.1 pyrophosphatase; has activity against dUTP and dITP; the crystal structure of the Vibrio protein showed similarity to Methanococcus janaschii Mj0226; in Vibrio cholerae this gene is part of the Mba operon that is involved in regulation and maintenance of biofilms; in Escherichia coli overexpression of this gene leads to resistance to an HMP analog YP_001591861.1 catalyzes reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate YP_001591862.1 KEGG: bat:BAS3585 5.2e-09 Ada regulatory protein/6-O-methylguanine-DNA methyltransferase K00567; COG: COG2207 AraC-type DNA-binding domain-containing proteins; Psort location: cytoplasmic, score: 23 YP_001591863.1 COG: COG3045 Uncharacterized protein conserved in bacteria; Psort location: extracellular, including cell wall, score: 9 YP_001591864.1 response regulator in two-component regulatory system with CreC; CreB protein is phosphorylated by sensor protein phospho-CreC; involved in catabolic regulation YP_001591865.1 part of a two-component regulatory system with CreB or PhoB; involved in catabolic regulation YP_001591866.1 COG: COG4452 Inner membrane protein involved in colicin E2 resistance; Psort location: plasma membrane, score: 23 YP_001591867.1 KEGG: ava:Ava_4160 0.00081 VCBS K01317; COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: mitochondrial, score: 23 YP_001591868.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001591869.1 COG: COG3188 P pilus assembly protein, porin PapC; Psort location: extracellular, including cell wall, score: 9 YP_001591870.1 COG: COG3121 P pilus assembly protein, chaperone PapD; Psort location: extracellular, including cell wall, score: 9 YP_001591871.1 COG: COG3539 P pilus assembly protein, pilin FimA; Psort location: extracellular, including cell wall, score: 9 YP_001591872.1 COG: NOG26670 non supervised orthologous group; Psort location: cytoplasmic, score: 23 YP_001591873.1 Psort location: cytoplasmic, score: 23 YP_001591874.1 Psort location: nuclear, score: 23 YP_001591875.1 COG: NOG26978 non supervised orthologous group; Psort location: mitochondrial, score: 23 YP_001591876.1 Psort location: mitochondrial, score: 23 YP_001591877.1 KEGG: eci:UTI89_C5174 6.1e-125 arcA; ArcA transcriptional dual regulator K07773; COG: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; Psort location: cytoplasmic, score: 23 YP_001591878.1 Psort location: mitochondrial, score: 23