-- dump date 20140620_054250 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1016998000001 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1016998000002 putative RNA methyltransferase; Provisional; Region: PRK10433 1016998000003 threonine operon leader 1016998000004 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 1016998000005 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1016998000006 putative catalytic residues [active] 1016998000007 putative nucleotide binding site [chemical binding]; other site 1016998000008 putative aspartate binding site [chemical binding]; other site 1016998000009 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 1016998000010 dimer interface [polypeptide binding]; other site 1016998000011 putative threonine allosteric regulatory site; other site 1016998000012 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 1016998000013 putative threonine allosteric regulatory site; other site 1016998000014 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1016998000015 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1016998000016 homoserine kinase; Provisional; Region: PRK01212 1016998000017 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1016998000018 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1016998000019 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1016998000020 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998000021 catalytic residue [active] 1016998000022 hypothetical protein; Validated; Region: PRK02101 1016998000023 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1016998000024 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1016998000025 transaldolase-like protein; Provisional; Region: PTZ00411 1016998000026 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1016998000027 active site 1016998000028 dimer interface [polypeptide binding]; other site 1016998000029 catalytic residue [active] 1016998000030 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1016998000031 MPT binding site; other site 1016998000032 trimer interface [polypeptide binding]; other site 1016998000033 hypothetical protein; Provisional; Region: PRK10659 1016998000034 hypothetical protein; Provisional; Region: PRK10236 1016998000035 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 1016998000036 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 1016998000037 hypothetical protein; Provisional; Region: PRK10154 1016998000038 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1016998000039 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1016998000040 nucleotide binding site [chemical binding]; other site 1016998000041 chaperone protein DnaJ; Provisional; Region: PRK10767 1016998000042 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1016998000043 HSP70 interaction site [polypeptide binding]; other site 1016998000044 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1016998000045 substrate binding site [polypeptide binding]; other site 1016998000046 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1016998000047 Zn binding sites [ion binding]; other site 1016998000048 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1016998000049 dimer interface [polypeptide binding]; other site 1016998000050 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1016998000051 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998000052 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1016998000053 substrate binding pocket [chemical binding]; other site 1016998000054 dimerization interface [polypeptide binding]; other site 1016998000055 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 1016998000056 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 1016998000057 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 1016998000058 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1016998000059 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 1016998000060 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1016998000061 active site 1016998000062 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 1016998000063 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1016998000064 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1016998000065 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1016998000066 Helix-turn-helix domain; Region: HTH_36; pfam13730 1016998000067 fimbrial protein BcfA; Provisional; Region: PRK15187 1016998000068 fimbrial chaperone protein BcfB; Provisional; Region: PRK15188 1016998000069 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1016998000070 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1016998000071 outer membrane usher protein; Provisional; Region: PRK15193 1016998000072 PapC N-terminal domain; Region: PapC_N; pfam13954 1016998000073 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1016998000074 PapC C-terminal domain; Region: PapC_C; pfam13953 1016998000075 fimbrial protein BcfD; Provisional; Region: PRK15189 1016998000076 fimbrial protein BcfE; Provisional; Region: PRK15190 1016998000077 fimbrial protein BcfF; Provisional; Region: PRK15191 1016998000078 fimbrial chaperone BcfG; Provisional; Region: PRK15192 1016998000079 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1016998000080 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1016998000081 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 1016998000082 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1016998000083 catalytic residues [active] 1016998000084 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1016998000085 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1016998000086 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 1016998000087 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1016998000088 Sulfatase; Region: Sulfatase; pfam00884 1016998000089 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1016998000090 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1016998000091 FeS/SAM binding site; other site 1016998000092 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1016998000093 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1016998000094 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 1016998000095 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 1016998000096 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998000097 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 1016998000098 putative dimerization interface [polypeptide binding]; other site 1016998000099 putative alpha-glucosidase; Provisional; Region: PRK10658 1016998000100 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1016998000101 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 1016998000102 putative active site [active] 1016998000103 putative catalytic site [active] 1016998000104 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1016998000105 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1016998000106 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1016998000107 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 1016998000108 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1016998000109 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1016998000110 active site 1016998000111 Riboflavin kinase; Region: Flavokinase; smart00904 1016998000112 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1016998000113 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1016998000114 active site 1016998000115 HIGH motif; other site 1016998000116 nucleotide binding site [chemical binding]; other site 1016998000117 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1016998000118 active site 1016998000119 KMSKS motif; other site 1016998000120 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1016998000121 tRNA binding surface [nucleotide binding]; other site 1016998000122 anticodon binding site; other site 1016998000123 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1016998000124 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1016998000125 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1016998000126 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1016998000127 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1016998000128 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1016998000129 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1016998000130 active site 1016998000131 tetramer interface [polypeptide binding]; other site 1016998000132 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1016998000133 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1016998000134 active site 1016998000135 phosphorylation site [posttranslational modification] 1016998000136 intermolecular recognition site; other site 1016998000137 dimerization interface [polypeptide binding]; other site 1016998000138 Transcriptional regulator; Region: CitT; pfam12431 1016998000139 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1016998000140 PAS domain; Region: PAS; smart00091 1016998000141 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1016998000142 ATP binding site [chemical binding]; other site 1016998000143 Mg2+ binding site [ion binding]; other site 1016998000144 G-X-G motif; other site 1016998000145 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 1016998000146 oxaloacetate decarboxylase; Provisional; Region: PRK14040 1016998000147 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1016998000148 active site 1016998000149 catalytic residues [active] 1016998000150 metal binding site [ion binding]; metal-binding site 1016998000151 homodimer binding site [polypeptide binding]; other site 1016998000152 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1016998000153 carboxyltransferase (CT) interaction site; other site 1016998000154 biotinylation site [posttranslational modification]; other site 1016998000155 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 1016998000156 Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493 1016998000157 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 1016998000158 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 1016998000159 putative active site [active] 1016998000160 (T/H)XGH motif; other site 1016998000161 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 1016998000162 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1016998000163 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 1016998000164 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1016998000165 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 1016998000166 triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125 1016998000167 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 1016998000168 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1016998000169 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1016998000170 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1016998000171 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1016998000172 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1016998000173 catalytic site [active] 1016998000174 subunit interface [polypeptide binding]; other site 1016998000175 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1016998000176 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1016998000177 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1016998000178 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1016998000179 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1016998000180 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1016998000181 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1016998000182 IMP binding site; other site 1016998000183 dimer interface [polypeptide binding]; other site 1016998000184 interdomain contacts; other site 1016998000185 partial ornithine binding site; other site 1016998000186 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 1016998000187 carnitine operon protein CaiE; Provisional; Region: PRK13627 1016998000188 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 1016998000189 putative trimer interface [polypeptide binding]; other site 1016998000190 putative metal binding site [ion binding]; other site 1016998000191 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 1016998000192 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1016998000193 substrate binding site [chemical binding]; other site 1016998000194 oxyanion hole (OAH) forming residues; other site 1016998000195 trimer interface [polypeptide binding]; other site 1016998000196 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 1016998000197 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1016998000198 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 1016998000199 acyl-activating enzyme (AAE) consensus motif; other site 1016998000200 putative AMP binding site [chemical binding]; other site 1016998000201 putative active site [active] 1016998000202 putative CoA binding site [chemical binding]; other site 1016998000203 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 1016998000204 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1016998000205 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 1016998000206 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1016998000207 active site 1016998000208 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 1016998000209 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1016998000210 Ligand binding site [chemical binding]; other site 1016998000211 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1016998000212 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 1016998000213 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 1016998000214 Ligand binding site [chemical binding]; other site 1016998000215 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1016998000216 putative oxidoreductase FixC; Provisional; Region: PRK10157 1016998000217 ferredoxin-like protein FixX; Provisional; Region: PRK15449 1016998000218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998000219 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1016998000220 putative substrate translocation pore; other site 1016998000221 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1016998000222 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1016998000223 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1016998000224 Sulfatase; Region: Sulfatase; cl17466 1016998000225 Sulfatase; Region: Sulfatase; cl17466 1016998000226 Sulfatase; Region: Sulfatase; cl17466 1016998000227 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 1016998000228 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 1016998000229 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1016998000230 TrkA-N domain; Region: TrkA_N; pfam02254 1016998000231 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1016998000232 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1016998000233 folate binding site [chemical binding]; other site 1016998000234 NADP+ binding site [chemical binding]; other site 1016998000235 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 1016998000236 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1016998000237 active site 1016998000238 metal binding site [ion binding]; metal-binding site 1016998000239 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1016998000240 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1016998000241 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1016998000242 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1016998000243 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1016998000244 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1016998000245 SurA N-terminal domain; Region: SurA_N; pfam09312 1016998000246 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1016998000247 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1016998000248 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 1016998000249 OstA-like protein; Region: OstA; pfam03968 1016998000250 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1016998000251 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 1016998000252 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1016998000253 putative metal binding site [ion binding]; other site 1016998000254 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1016998000255 HSP70 interaction site [polypeptide binding]; other site 1016998000256 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1016998000257 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1016998000258 active site 1016998000259 ATP-dependent helicase HepA; Validated; Region: PRK04914 1016998000260 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1016998000261 ATP binding site [chemical binding]; other site 1016998000262 putative Mg++ binding site [ion binding]; other site 1016998000263 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1016998000264 nucleotide binding region [chemical binding]; other site 1016998000265 ATP-binding site [chemical binding]; other site 1016998000266 DNA polymerase II; Reviewed; Region: PRK05762 1016998000267 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 1016998000268 active site 1016998000269 catalytic site [active] 1016998000270 substrate binding site [chemical binding]; other site 1016998000271 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 1016998000272 active site 1016998000273 metal-binding site 1016998000274 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1016998000275 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1016998000276 putative active site [active] 1016998000277 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1016998000278 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1016998000279 intersubunit interface [polypeptide binding]; other site 1016998000280 active site 1016998000281 Zn2+ binding site [ion binding]; other site 1016998000282 L-arabinose isomerase; Provisional; Region: PRK02929 1016998000283 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1016998000284 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1016998000285 trimer interface [polypeptide binding]; other site 1016998000286 putative substrate binding site [chemical binding]; other site 1016998000287 putative metal binding site [ion binding]; other site 1016998000288 ribulokinase; Provisional; Region: PRK04123 1016998000289 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1016998000290 N- and C-terminal domain interface [polypeptide binding]; other site 1016998000291 active site 1016998000292 MgATP binding site [chemical binding]; other site 1016998000293 catalytic site [active] 1016998000294 metal binding site [ion binding]; metal-binding site 1016998000295 carbohydrate binding site [chemical binding]; other site 1016998000296 homodimer interface [polypeptide binding]; other site 1016998000297 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 1016998000298 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1016998000299 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1016998000300 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1016998000301 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1016998000302 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1016998000303 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 1016998000304 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 1016998000305 Walker A/P-loop; other site 1016998000306 ATP binding site [chemical binding]; other site 1016998000307 Q-loop/lid; other site 1016998000308 ABC transporter signature motif; other site 1016998000309 Walker B; other site 1016998000310 D-loop; other site 1016998000311 H-loop/switch region; other site 1016998000312 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 1016998000313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998000314 dimer interface [polypeptide binding]; other site 1016998000315 conserved gate region; other site 1016998000316 putative PBP binding loops; other site 1016998000317 ABC-ATPase subunit interface; other site 1016998000318 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998000319 dimer interface [polypeptide binding]; other site 1016998000320 conserved gate region; other site 1016998000321 putative PBP binding loops; other site 1016998000322 ABC-ATPase subunit interface; other site 1016998000323 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 1016998000324 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1016998000325 TPP riboswitch (THI element) 1016998000326 transcriptional regulator SgrR; Provisional; Region: PRK13626 1016998000327 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1016998000328 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1016998000329 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1016998000330 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1016998000331 substrate binding site [chemical binding]; other site 1016998000332 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1016998000333 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1016998000334 substrate binding site [chemical binding]; other site 1016998000335 ligand binding site [chemical binding]; other site 1016998000336 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1016998000337 tartrate dehydrogenase; Region: TTC; TIGR02089 1016998000338 2-isopropylmalate synthase; Validated; Region: PRK00915 1016998000339 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1016998000340 active site 1016998000341 catalytic residues [active] 1016998000342 metal binding site [ion binding]; metal-binding site 1016998000343 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1016998000344 leucine operon leader 1016998000345 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1016998000346 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998000347 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 1016998000348 putative substrate binding pocket [chemical binding]; other site 1016998000349 putative dimerization interface [polypeptide binding]; other site 1016998000350 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 1016998000351 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1016998000352 PYR/PP interface [polypeptide binding]; other site 1016998000353 dimer interface [polypeptide binding]; other site 1016998000354 TPP binding site [chemical binding]; other site 1016998000355 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1016998000356 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1016998000357 TPP-binding site [chemical binding]; other site 1016998000358 dimer interface [polypeptide binding]; other site 1016998000359 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1016998000360 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1016998000361 putative valine binding site [chemical binding]; other site 1016998000362 dimer interface [polypeptide binding]; other site 1016998000363 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1016998000364 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 1016998000365 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1016998000366 DNA binding site [nucleotide binding] 1016998000367 domain linker motif; other site 1016998000368 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1016998000369 dimerization interface [polypeptide binding]; other site 1016998000370 ligand binding site [chemical binding]; other site 1016998000371 mraZ protein; Region: TIGR00242 1016998000372 MraZ protein; Region: MraZ; pfam02381 1016998000373 MraZ protein; Region: MraZ; pfam02381 1016998000374 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 1016998000375 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1016998000376 cell division protein FtsL; Provisional; Region: PRK10772 1016998000377 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1016998000378 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1016998000379 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1016998000380 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1016998000381 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1016998000382 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1016998000383 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1016998000384 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 1016998000385 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1016998000386 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1016998000387 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1016998000388 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1016998000389 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1016998000390 Mg++ binding site [ion binding]; other site 1016998000391 putative catalytic motif [active] 1016998000392 putative substrate binding site [chemical binding]; other site 1016998000393 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 1016998000394 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1016998000395 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1016998000396 cell division protein FtsW; Provisional; Region: PRK10774 1016998000397 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1016998000398 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1016998000399 active site 1016998000400 homodimer interface [polypeptide binding]; other site 1016998000401 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1016998000402 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1016998000403 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1016998000404 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1016998000405 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1016998000406 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1016998000407 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1016998000408 cell division protein FtsQ; Provisional; Region: PRK10775 1016998000409 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1016998000410 Cell division protein FtsQ; Region: FtsQ; pfam03799 1016998000411 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 1016998000412 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1016998000413 Cell division protein FtsA; Region: FtsA; pfam14450 1016998000414 cell division protein FtsZ; Validated; Region: PRK09330 1016998000415 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1016998000416 nucleotide binding site [chemical binding]; other site 1016998000417 SulA interaction site; other site 1016998000418 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 1016998000419 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1016998000420 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1016998000421 SecA regulator SecM; Provisional; Region: PRK02943 1016998000422 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1016998000423 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1016998000424 SEC-C motif; Region: SEC-C; pfam02810 1016998000425 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1016998000426 active site 1016998000427 8-oxo-dGMP binding site [chemical binding]; other site 1016998000428 nudix motif; other site 1016998000429 metal binding site [ion binding]; metal-binding site 1016998000430 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1016998000431 DNA gyrase inhibitor; Reviewed; Region: PRK00418 1016998000432 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 1016998000433 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1016998000434 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1016998000435 CoA-binding site [chemical binding]; other site 1016998000436 ATP-binding [chemical binding]; other site 1016998000437 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 1016998000438 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1016998000439 active site 1016998000440 type IV pilin biogenesis protein; Provisional; Region: PRK10573 1016998000441 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1016998000442 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1016998000443 hypothetical protein; Provisional; Region: PRK10436 1016998000444 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1016998000445 Walker A motif; other site 1016998000446 ATP binding site [chemical binding]; other site 1016998000447 Walker B motif; other site 1016998000448 putative major pilin subunit; Provisional; Region: PRK10574 1016998000449 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1016998000450 Pilin (bacterial filament); Region: Pilin; pfam00114 1016998000451 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 1016998000452 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1016998000453 dimerization interface [polypeptide binding]; other site 1016998000454 active site 1016998000455 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1016998000456 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1016998000457 amidase catalytic site [active] 1016998000458 Zn binding residues [ion binding]; other site 1016998000459 substrate binding site [chemical binding]; other site 1016998000460 regulatory protein AmpE; Provisional; Region: PRK10987 1016998000461 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 1016998000462 active site 1016998000463 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1016998000464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998000465 putative substrate translocation pore; other site 1016998000466 aromatic amino acid transporter; Provisional; Region: PRK10238 1016998000467 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 1016998000468 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1016998000469 DNA-binding site [nucleotide binding]; DNA binding site 1016998000470 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1016998000471 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1016998000472 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1016998000473 dimer interface [polypeptide binding]; other site 1016998000474 TPP-binding site [chemical binding]; other site 1016998000475 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 1016998000476 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1016998000477 E3 interaction surface; other site 1016998000478 lipoyl attachment site [posttranslational modification]; other site 1016998000479 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1016998000480 E3 interaction surface; other site 1016998000481 lipoyl attachment site [posttranslational modification]; other site 1016998000482 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1016998000483 E3 interaction surface; other site 1016998000484 lipoyl attachment site [posttranslational modification]; other site 1016998000485 e3 binding domain; Region: E3_binding; pfam02817 1016998000486 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1016998000487 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1016998000488 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1016998000489 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1016998000490 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1016998000491 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 1016998000492 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 1016998000493 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1016998000494 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1016998000495 substrate binding site [chemical binding]; other site 1016998000496 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1016998000497 substrate binding site [chemical binding]; other site 1016998000498 ligand binding site [chemical binding]; other site 1016998000499 hypothetical protein; Provisional; Region: PRK05248 1016998000500 2-keto-3-deoxygluconate permease; Provisional; Region: PRK12460 1016998000501 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1016998000502 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1016998000503 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 1016998000504 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1016998000505 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1016998000506 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1016998000507 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 1016998000508 spermidine synthase; Provisional; Region: PRK00811 1016998000509 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1016998000510 S-adenosylmethionine binding site [chemical binding]; other site 1016998000511 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 1016998000512 multicopper oxidase; Provisional; Region: PRK10965 1016998000513 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1016998000514 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1016998000515 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1016998000516 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1016998000517 Trp docking motif [polypeptide binding]; other site 1016998000518 putative active site [active] 1016998000519 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1016998000520 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1016998000521 active site 1016998000522 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1016998000523 active site clefts [active] 1016998000524 zinc binding site [ion binding]; other site 1016998000525 dimer interface [polypeptide binding]; other site 1016998000526 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1016998000527 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1016998000528 Walker A/P-loop; other site 1016998000529 ATP binding site [chemical binding]; other site 1016998000530 Q-loop/lid; other site 1016998000531 ABC transporter signature motif; other site 1016998000532 Walker B; other site 1016998000533 D-loop; other site 1016998000534 H-loop/switch region; other site 1016998000535 inner membrane transport permease; Provisional; Region: PRK15066 1016998000536 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1016998000537 putative fimbrial protein StiH; Provisional; Region: PRK15297 1016998000538 fimbrial outer membrane usher protein StiC; Provisional; Region: PRK15298 1016998000539 PapC N-terminal domain; Region: PapC_N; pfam13954 1016998000540 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1016998000541 PapC C-terminal domain; Region: PapC_C; pfam13953 1016998000542 fimbrial chaperone protein StiB; Provisional; Region: PRK15299 1016998000543 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1016998000544 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1016998000545 fimbrial protein StiA; Provisional; Region: PRK15300 1016998000546 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1016998000547 active pocket/dimerization site; other site 1016998000548 active site 1016998000549 phosphorylation site [posttranslational modification] 1016998000550 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 1016998000551 putative active site [active] 1016998000552 putative metal binding site [ion binding]; other site 1016998000553 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1016998000554 tetramerization interface [polypeptide binding]; other site 1016998000555 active site 1016998000556 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1016998000557 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1016998000558 active site 1016998000559 ATP-binding site [chemical binding]; other site 1016998000560 pantoate-binding site; other site 1016998000561 HXXH motif; other site 1016998000562 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1016998000563 oligomerization interface [polypeptide binding]; other site 1016998000564 active site 1016998000565 metal binding site [ion binding]; metal-binding site 1016998000566 putative fimbrial-like adhesin protein; Provisional; Region: PRK09723 1016998000567 putative fimbrial protein StaF; Provisional; Region: PRK15262 1016998000568 putative fimbrial protein StaE; Provisional; Region: PRK15263 1016998000569 putative fimbrial protein StaD; Provisional; Region: PRK15241 1016998000570 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 1016998000571 PapC N-terminal domain; Region: PapC_N; pfam13954 1016998000572 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1016998000573 PapC C-terminal domain; Region: PapC_C; pfam13953 1016998000574 putative chaperone protein EcpD; Provisional; Region: PRK09926 1016998000575 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1016998000576 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1016998000577 putative fimbrial protein StaA; Provisional; Region: PRK15239 1016998000578 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1016998000579 catalytic center binding site [active] 1016998000580 ATP binding site [chemical binding]; other site 1016998000581 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 1016998000582 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1016998000583 active site 1016998000584 NTP binding site [chemical binding]; other site 1016998000585 metal binding triad [ion binding]; metal-binding site 1016998000586 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1016998000587 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1016998000588 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 1016998000589 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1016998000590 active site 1016998000591 nucleotide binding site [chemical binding]; other site 1016998000592 HIGH motif; other site 1016998000593 KMSKS motif; other site 1016998000594 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 1016998000595 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1016998000596 2'-5' RNA ligase; Provisional; Region: PRK15124 1016998000597 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1016998000598 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1016998000599 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 1016998000600 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1016998000601 ATP binding site [chemical binding]; other site 1016998000602 putative Mg++ binding site [ion binding]; other site 1016998000603 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1016998000604 nucleotide binding region [chemical binding]; other site 1016998000605 ATP-binding site [chemical binding]; other site 1016998000606 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1016998000607 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 1016998000608 Transglycosylase; Region: Transgly; pfam00912 1016998000609 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1016998000610 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1016998000611 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1016998000612 N-terminal plug; other site 1016998000613 ligand-binding site [chemical binding]; other site 1016998000614 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 1016998000615 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1016998000616 Walker A/P-loop; other site 1016998000617 ATP binding site [chemical binding]; other site 1016998000618 Q-loop/lid; other site 1016998000619 ABC transporter signature motif; other site 1016998000620 Walker B; other site 1016998000621 D-loop; other site 1016998000622 H-loop/switch region; other site 1016998000623 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1016998000624 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1016998000625 siderophore binding site; other site 1016998000626 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1016998000627 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1016998000628 ABC-ATPase subunit interface; other site 1016998000629 dimer interface [polypeptide binding]; other site 1016998000630 putative PBP binding regions; other site 1016998000631 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1016998000632 ABC-ATPase subunit interface; other site 1016998000633 dimer interface [polypeptide binding]; other site 1016998000634 putative PBP binding regions; other site 1016998000635 putative fimbrial subunit StfA; Provisional; Region: PRK15283 1016998000636 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 1016998000637 PapC N-terminal domain; Region: PapC_N; pfam13954 1016998000638 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1016998000639 PapC C-terminal domain; Region: PapC_C; pfam13953 1016998000640 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 1016998000641 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1016998000642 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1016998000643 putative minor fimbrial subunit StfE; Provisional; Region: PRK15286 1016998000644 putative minor fimbrial subunit StfF; Provisional; Region: PRK15287 1016998000645 putative minor fimbrial subunit StfG; Provisional; Region: PRK15288 1016998000646 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 1016998000647 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1016998000648 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1016998000649 inhibitor-cofactor binding pocket; inhibition site 1016998000650 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998000651 catalytic residue [active] 1016998000652 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1016998000653 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1016998000654 Cl- selectivity filter; other site 1016998000655 Cl- binding residues [ion binding]; other site 1016998000656 pore gating glutamate residue; other site 1016998000657 dimer interface [polypeptide binding]; other site 1016998000658 H+/Cl- coupling transport residue; other site 1016998000659 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1016998000660 hypothetical protein; Provisional; Region: PRK10578 1016998000661 UPF0126 domain; Region: UPF0126; pfam03458 1016998000662 UPF0126 domain; Region: UPF0126; pfam03458 1016998000663 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 1016998000664 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1016998000665 cobalamin binding residues [chemical binding]; other site 1016998000666 putative BtuC binding residues; other site 1016998000667 dimer interface [polypeptide binding]; other site 1016998000668 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1016998000669 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1016998000670 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 1016998000671 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1016998000672 Zn2+ binding site [ion binding]; other site 1016998000673 Mg2+ binding site [ion binding]; other site 1016998000674 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1016998000675 serine endoprotease; Provisional; Region: PRK10942 1016998000676 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1016998000677 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1016998000678 protein binding site [polypeptide binding]; other site 1016998000679 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1016998000680 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 1016998000681 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1016998000682 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1016998000683 hypothetical protein; Provisional; Region: PRK13677 1016998000684 shikimate transporter; Provisional; Region: PRK09952 1016998000685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998000686 putative substrate translocation pore; other site 1016998000687 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1016998000688 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1016998000689 trimer interface [polypeptide binding]; other site 1016998000690 active site 1016998000691 substrate binding site [chemical binding]; other site 1016998000692 CoA binding site [chemical binding]; other site 1016998000693 PII uridylyl-transferase; Provisional; Region: PRK05007 1016998000694 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1016998000695 metal binding triad; other site 1016998000696 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1016998000697 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1016998000698 Zn2+ binding site [ion binding]; other site 1016998000699 Mg2+ binding site [ion binding]; other site 1016998000700 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1016998000701 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1016998000702 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1016998000703 active site 1016998000704 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1016998000705 rRNA interaction site [nucleotide binding]; other site 1016998000706 S8 interaction site; other site 1016998000707 putative laminin-1 binding site; other site 1016998000708 elongation factor Ts; Provisional; Region: tsf; PRK09377 1016998000709 UBA/TS-N domain; Region: UBA; pfam00627 1016998000710 Elongation factor TS; Region: EF_TS; pfam00889 1016998000711 Elongation factor TS; Region: EF_TS; pfam00889 1016998000712 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1016998000713 putative nucleotide binding site [chemical binding]; other site 1016998000714 uridine monophosphate binding site [chemical binding]; other site 1016998000715 homohexameric interface [polypeptide binding]; other site 1016998000716 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1016998000717 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1016998000718 hinge region; other site 1016998000719 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1016998000720 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1016998000721 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1016998000722 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1016998000723 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1016998000724 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1016998000725 catalytic residue [active] 1016998000726 putative FPP diphosphate binding site; other site 1016998000727 putative FPP binding hydrophobic cleft; other site 1016998000728 dimer interface [polypeptide binding]; other site 1016998000729 putative IPP diphosphate binding site; other site 1016998000730 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 1016998000731 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1016998000732 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1016998000733 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1016998000734 active site 1016998000735 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1016998000736 protein binding site [polypeptide binding]; other site 1016998000737 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1016998000738 protein binding site [polypeptide binding]; other site 1016998000739 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1016998000740 putative substrate binding region [chemical binding]; other site 1016998000741 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 1016998000742 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1016998000743 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1016998000744 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1016998000745 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1016998000746 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1016998000747 Surface antigen; Region: Bac_surface_Ag; pfam01103 1016998000748 periplasmic chaperone; Provisional; Region: PRK10780 1016998000749 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1016998000750 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1016998000751 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1016998000752 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1016998000753 trimer interface [polypeptide binding]; other site 1016998000754 active site 1016998000755 UDP-GlcNAc binding site [chemical binding]; other site 1016998000756 lipid binding site [chemical binding]; lipid-binding site 1016998000757 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1016998000758 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1016998000759 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1016998000760 active site 1016998000761 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1016998000762 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1016998000763 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1016998000764 RNA/DNA hybrid binding site [nucleotide binding]; other site 1016998000765 active site 1016998000766 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1016998000767 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1016998000768 putative active site [active] 1016998000769 putative PHP Thumb interface [polypeptide binding]; other site 1016998000770 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1016998000771 generic binding surface II; other site 1016998000772 generic binding surface I; other site 1016998000773 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1016998000774 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1016998000775 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 1016998000776 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 1016998000777 putative sugar binding site [chemical binding]; other site 1016998000778 catalytic residues [active] 1016998000779 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 1016998000780 lysine decarboxylase LdcC; Provisional; Region: PRK15399 1016998000781 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1016998000782 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1016998000783 homodimer interface [polypeptide binding]; other site 1016998000784 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998000785 catalytic residue [active] 1016998000786 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1016998000787 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1016998000788 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1016998000789 putative metal binding site [ion binding]; other site 1016998000790 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 1016998000791 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1016998000792 Ligand Binding Site [chemical binding]; other site 1016998000793 TilS substrate binding domain; Region: TilS; pfam09179 1016998000794 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 1016998000795 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 1016998000796 hypothetical protein; Provisional; Region: PRK04964 1016998000797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 1016998000798 hypothetical protein; Provisional; Region: PRK09256 1016998000799 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1016998000800 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 1016998000801 NlpE N-terminal domain; Region: NlpE; pfam04170 1016998000802 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1016998000803 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1016998000804 dimer interface [polypeptide binding]; other site 1016998000805 motif 1; other site 1016998000806 active site 1016998000807 motif 2; other site 1016998000808 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1016998000809 putative deacylase active site [active] 1016998000810 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1016998000811 active site 1016998000812 motif 3; other site 1016998000813 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1016998000814 anticodon binding site; other site 1016998000815 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1016998000816 homodimer interaction site [polypeptide binding]; other site 1016998000817 cofactor binding site; other site 1016998000818 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 1016998000819 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 1016998000820 lipoprotein, YaeC family; Region: TIGR00363 1016998000821 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998000822 dimer interface [polypeptide binding]; other site 1016998000823 conserved gate region; other site 1016998000824 ABC-ATPase subunit interface; other site 1016998000825 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1016998000826 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1016998000827 Walker A/P-loop; other site 1016998000828 ATP binding site [chemical binding]; other site 1016998000829 Q-loop/lid; other site 1016998000830 ABC transporter signature motif; other site 1016998000831 Walker B; other site 1016998000832 D-loop; other site 1016998000833 H-loop/switch region; other site 1016998000834 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1016998000835 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 1016998000836 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1016998000837 active site 1016998000838 motif I; other site 1016998000839 motif II; other site 1016998000840 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 1016998000841 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1016998000842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998000843 putative substrate translocation pore; other site 1016998000844 lipoprotein; Provisional; Region: PRK10759 1016998000845 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 1016998000846 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 1016998000847 domain interface [polypeptide binding]; other site 1016998000848 putative active site [active] 1016998000849 catalytic site [active] 1016998000850 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 1016998000851 domain interface [polypeptide binding]; other site 1016998000852 putative active site [active] 1016998000853 catalytic site [active] 1016998000854 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1016998000855 CoA binding domain; Region: CoA_binding_2; pfam13380 1016998000856 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1016998000857 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1016998000858 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1016998000859 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1016998000860 Coenzyme A binding pocket [chemical binding]; other site 1016998000861 Uncharacterized conserved protein [Function unknown]; Region: COG3148 1016998000862 thioredoxin 2; Provisional; Region: PRK10996 1016998000863 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 1016998000864 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1016998000865 catalytic residues [active] 1016998000866 putative methyltransferase; Provisional; Region: PRK10864 1016998000867 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1016998000868 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1016998000869 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1016998000870 ligand binding site [chemical binding]; other site 1016998000871 active site 1016998000872 UGI interface [polypeptide binding]; other site 1016998000873 catalytic site [active] 1016998000874 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 1016998000875 LysE type translocator; Region: LysE; cl00565 1016998000876 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1016998000877 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998000878 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1016998000879 dimerization interface [polypeptide binding]; other site 1016998000880 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1016998000881 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1016998000882 ATP binding site [chemical binding]; other site 1016998000883 Mg++ binding site [ion binding]; other site 1016998000884 motif III; other site 1016998000885 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1016998000886 nucleotide binding region [chemical binding]; other site 1016998000887 ATP-binding site [chemical binding]; other site 1016998000888 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1016998000889 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1016998000890 S-adenosylmethionine binding site [chemical binding]; other site 1016998000891 L-aspartate oxidase; Provisional; Region: PRK09077 1016998000892 L-aspartate oxidase; Provisional; Region: PRK06175 1016998000893 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1016998000894 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 1016998000895 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1016998000896 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1016998000897 DNA binding residues [nucleotide binding] 1016998000898 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 1016998000899 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 1016998000900 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 1016998000901 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 1016998000902 anti-sigma E factor; Provisional; Region: rseB; PRK09455 1016998000903 SoxR reducing system protein RseC; Provisional; Region: PRK10862 1016998000904 GTP-binding protein LepA; Provisional; Region: PRK05433 1016998000905 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1016998000906 Switch I region; other site 1016998000907 G2 box; other site 1016998000908 putative GEF interaction site [polypeptide binding]; other site 1016998000909 G3 box; other site 1016998000910 Switch II region; other site 1016998000911 GTP/Mg2+ binding site [chemical binding]; other site 1016998000912 G4 box; other site 1016998000913 G5 box; other site 1016998000914 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1016998000915 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1016998000916 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1016998000917 signal peptidase I; Provisional; Region: PRK10861 1016998000918 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1016998000919 Catalytic site [active] 1016998000920 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1016998000921 rncO; Rfam score 225.63; SPAB_00345 1016998000922 GTPase Era; Reviewed; Region: era; PRK00089 1016998000923 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1016998000924 G1 box; other site 1016998000925 GTP/Mg2+ binding site [chemical binding]; other site 1016998000926 Switch I region; other site 1016998000927 G2 box; other site 1016998000928 Switch II region; other site 1016998000929 G3 box; other site 1016998000930 G4 box; other site 1016998000931 G5 box; other site 1016998000932 KH domain; Region: KH_2; pfam07650 1016998000933 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1016998000934 Recombination protein O N terminal; Region: RecO_N; pfam11967 1016998000935 Recombination protein O C terminal; Region: RecO_C; pfam02565 1016998000936 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1016998000937 active site 1016998000938 hydrophilic channel; other site 1016998000939 dimerization interface [polypeptide binding]; other site 1016998000940 catalytic residues [active] 1016998000941 active site lid [active] 1016998000942 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1016998000943 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1016998000944 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998000945 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1016998000946 dimerization interface [polypeptide binding]; other site 1016998000947 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1016998000948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998000949 putative substrate translocation pore; other site 1016998000950 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1016998000951 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1016998000952 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1016998000953 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1016998000954 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 1016998000955 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1016998000956 putative active site [active] 1016998000957 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1016998000958 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1016998000959 putative active site [active] 1016998000960 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1016998000961 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1016998000962 active site turn [active] 1016998000963 phosphorylation site [posttranslational modification] 1016998000964 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1016998000965 hypothetical protein; Provisional; Region: PRK11590 1016998000966 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1016998000967 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1016998000968 nucleoside/Zn binding site; other site 1016998000969 dimer interface [polypeptide binding]; other site 1016998000970 catalytic motif [active] 1016998000971 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 1016998000972 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1016998000973 substrate binding pocket [chemical binding]; other site 1016998000974 membrane-bound complex binding site; other site 1016998000975 hinge residues; other site 1016998000976 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1016998000977 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1016998000978 catalytic residue [active] 1016998000979 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1016998000980 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1016998000981 dimerization interface [polypeptide binding]; other site 1016998000982 ATP binding site [chemical binding]; other site 1016998000983 Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of...; Region: PurL; cd02193 1016998000984 dimerization interface [polypeptide binding]; other site 1016998000985 ATP binding site [chemical binding]; other site 1016998000986 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1016998000987 putative active site [active] 1016998000988 catalytic triad [active] 1016998000989 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1016998000990 HAMP domain; Region: HAMP; pfam00672 1016998000991 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1016998000992 dimer interface [polypeptide binding]; other site 1016998000993 phosphorylation site [posttranslational modification] 1016998000994 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1016998000995 ATP binding site [chemical binding]; other site 1016998000996 Mg2+ binding site [ion binding]; other site 1016998000997 G-X-G motif; other site 1016998000998 hypothetical protein; Provisional; Region: PRK10722 1016998000999 response regulator GlrR; Provisional; Region: PRK15115 1016998001000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1016998001001 active site 1016998001002 phosphorylation site [posttranslational modification] 1016998001003 intermolecular recognition site; other site 1016998001004 dimerization interface [polypeptide binding]; other site 1016998001005 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1016998001006 Walker A motif; other site 1016998001007 ATP binding site [chemical binding]; other site 1016998001008 Walker B motif; other site 1016998001009 arginine finger; other site 1016998001010 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 1016998001011 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1016998001012 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1016998001013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998001014 putative substrate translocation pore; other site 1016998001015 POT family; Region: PTR2; pfam00854 1016998001016 lysine decarboxylase CadA; Provisional; Region: PRK15400 1016998001017 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1016998001018 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1016998001019 homodimer interface [polypeptide binding]; other site 1016998001020 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998001021 catalytic residue [active] 1016998001022 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1016998001023 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 1016998001024 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 1016998001025 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1016998001026 DNA binding site [nucleotide binding] 1016998001027 glucose-6-phosphate 1-dehydrogenase; Region: PLN02539 1016998001028 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1016998001029 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1016998001030 heme-binding site [chemical binding]; other site 1016998001031 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1016998001032 FAD binding pocket [chemical binding]; other site 1016998001033 FAD binding motif [chemical binding]; other site 1016998001034 phosphate binding motif [ion binding]; other site 1016998001035 beta-alpha-beta structure motif; other site 1016998001036 NAD binding pocket [chemical binding]; other site 1016998001037 Heme binding pocket [chemical binding]; other site 1016998001038 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1016998001039 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1016998001040 dimer interface [polypeptide binding]; other site 1016998001041 active site 1016998001042 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1016998001043 folate binding site [chemical binding]; other site 1016998001044 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1016998001045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998001046 putative substrate translocation pore; other site 1016998001047 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 1016998001048 PRD domain; Region: PRD; pfam00874 1016998001049 PRD domain; Region: PRD; pfam00874 1016998001050 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 1016998001051 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 1016998001052 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 1016998001053 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1016998001054 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1016998001055 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 1016998001056 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 1016998001057 FAD binding pocket [chemical binding]; other site 1016998001058 FAD binding motif [chemical binding]; other site 1016998001059 phosphate binding motif [ion binding]; other site 1016998001060 beta-alpha-beta structure motif; other site 1016998001061 NAD binding pocket [chemical binding]; other site 1016998001062 Iron coordination center [ion binding]; other site 1016998001063 sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910 1016998001064 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1016998001065 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1016998001066 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1016998001067 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1016998001068 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1016998001069 active site 1016998001070 dimerization interface [polypeptide binding]; other site 1016998001071 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 1016998001072 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1016998001073 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 1016998001074 Rrf2 family protein; Region: rrf2_super; TIGR00738 1016998001075 cysteine desulfurase; Provisional; Region: PRK14012 1016998001076 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1016998001077 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1016998001078 catalytic residue [active] 1016998001079 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1016998001080 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1016998001081 trimerization site [polypeptide binding]; other site 1016998001082 active site 1016998001083 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 1016998001084 co-chaperone HscB; Provisional; Region: hscB; PRK05014 1016998001085 DnaJ domain; Region: DnaJ; pfam00226 1016998001086 HSP70 interaction site [polypeptide binding]; other site 1016998001087 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 1016998001088 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1016998001089 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 1016998001090 nucleotide binding site [chemical binding]; other site 1016998001091 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1016998001092 SBD interface [polypeptide binding]; other site 1016998001093 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1016998001094 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1016998001095 catalytic loop [active] 1016998001096 iron binding site [ion binding]; other site 1016998001097 hypothetical protein; Provisional; Region: PRK10721 1016998001098 aminopeptidase B; Provisional; Region: PRK05015 1016998001099 Peptidase; Region: DUF3663; pfam12404 1016998001100 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1016998001101 interface (dimer of trimers) [polypeptide binding]; other site 1016998001102 Substrate-binding/catalytic site; other site 1016998001103 Zn-binding sites [ion binding]; other site 1016998001104 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 1016998001105 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 1016998001106 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1016998001107 active site residue [active] 1016998001108 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1016998001109 active site residue [active] 1016998001110 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1016998001111 MG2 domain; Region: A2M_N; pfam01835 1016998001112 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1016998001113 surface patch; other site 1016998001114 thioester region; other site 1016998001115 specificity defining residues; other site 1016998001116 penicillin-binding protein 1C; Provisional; Region: PRK11240 1016998001117 Transglycosylase; Region: Transgly; pfam00912 1016998001118 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1016998001119 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 1016998001120 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1016998001121 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1016998001122 putative [Fe4-S4] binding site [ion binding]; other site 1016998001123 putative molybdopterin cofactor binding site [chemical binding]; other site 1016998001124 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1016998001125 putative molybdopterin cofactor binding site; other site 1016998001126 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1016998001127 4Fe-4S binding domain; Region: Fer4; pfam00037 1016998001128 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 1016998001129 4Fe-4S binding domain; Region: Fer4; pfam00037 1016998001130 hydrogenase 4 subunit H; Validated; Region: PRK08222 1016998001131 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1016998001132 active site 1016998001133 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1016998001134 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1016998001135 FeS/SAM binding site; other site 1016998001136 cytoskeletal protein RodZ; Provisional; Region: PRK10856 1016998001137 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1016998001138 non-specific DNA binding site [nucleotide binding]; other site 1016998001139 salt bridge; other site 1016998001140 sequence-specific DNA binding site [nucleotide binding]; other site 1016998001141 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1016998001142 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1016998001143 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1016998001144 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1016998001145 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1016998001146 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1016998001147 dimer interface [polypeptide binding]; other site 1016998001148 motif 1; other site 1016998001149 active site 1016998001150 motif 2; other site 1016998001151 motif 3; other site 1016998001152 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1016998001153 anticodon binding site; other site 1016998001154 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1016998001155 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 1016998001156 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 1016998001157 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1016998001158 Trp docking motif [polypeptide binding]; other site 1016998001159 active site 1016998001160 GTP-binding protein Der; Reviewed; Region: PRK00093 1016998001161 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1016998001162 G1 box; other site 1016998001163 GTP/Mg2+ binding site [chemical binding]; other site 1016998001164 Switch I region; other site 1016998001165 G2 box; other site 1016998001166 Switch II region; other site 1016998001167 G3 box; other site 1016998001168 G4 box; other site 1016998001169 G5 box; other site 1016998001170 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1016998001171 G1 box; other site 1016998001172 GTP/Mg2+ binding site [chemical binding]; other site 1016998001173 Switch I region; other site 1016998001174 G2 box; other site 1016998001175 G3 box; other site 1016998001176 Switch II region; other site 1016998001177 G4 box; other site 1016998001178 G5 box; other site 1016998001179 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 1016998001180 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1016998001181 intimin-like protein SinH; Provisional; Region: PRK15318 1016998001182 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1016998001183 intimin-like protein SinH; Provisional; Region: PRK15318 1016998001184 outer membrane protein RatA; Provisional; Region: PRK15315 1016998001185 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1016998001186 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1016998001187 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1016998001188 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1016998001189 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1016998001190 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1016998001191 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1016998001192 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1016998001193 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1016998001194 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1016998001195 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1016998001196 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1016998001197 outer membrane protein RatB; Provisional; Region: PRK15314 1016998001198 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1016998001199 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1016998001200 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1016998001201 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1016998001202 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1016998001203 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1016998001204 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1016998001205 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1016998001206 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1016998001207 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1016998001208 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1016998001209 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1016998001210 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1016998001211 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1016998001212 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1016998001213 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1016998001214 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 1016998001215 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 1016998001216 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1016998001217 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1016998001218 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1016998001219 Autotransporter beta-domain; Region: Autotransporter; smart00869 1016998001220 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1016998001221 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1016998001222 generic binding surface II; other site 1016998001223 generic binding surface I; other site 1016998001224 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1016998001225 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1016998001226 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1016998001227 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1016998001228 active site 1016998001229 GMP synthase; Reviewed; Region: guaA; PRK00074 1016998001230 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1016998001231 AMP/PPi binding site [chemical binding]; other site 1016998001232 candidate oxyanion hole; other site 1016998001233 catalytic triad [active] 1016998001234 potential glutamine specificity residues [chemical binding]; other site 1016998001235 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1016998001236 ATP Binding subdomain [chemical binding]; other site 1016998001237 Ligand Binding sites [chemical binding]; other site 1016998001238 Dimerization subdomain; other site 1016998001239 Integrase core domain; Region: rve; pfam00665 1016998001240 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1016998001241 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 1016998001242 MASE1; Region: MASE1; pfam05231 1016998001243 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1016998001244 diguanylate cyclase; Region: GGDEF; smart00267 1016998001245 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1016998001246 exopolyphosphatase; Provisional; Region: PRK10854 1016998001247 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1016998001248 nucleotide binding site [chemical binding]; other site 1016998001249 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 1016998001250 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1016998001251 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1016998001252 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1016998001253 putative active site [active] 1016998001254 catalytic site [active] 1016998001255 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 1016998001256 domain interface [polypeptide binding]; other site 1016998001257 active site 1016998001258 catalytic site [active] 1016998001259 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1016998001260 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1016998001261 active site 1016998001262 substrate binding site [chemical binding]; other site 1016998001263 cosubstrate binding site; other site 1016998001264 catalytic site [active] 1016998001265 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1016998001266 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1016998001267 dimerization interface [polypeptide binding]; other site 1016998001268 putative ATP binding site [chemical binding]; other site 1016998001269 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1016998001270 active site 1016998001271 uracil transporter; Provisional; Region: PRK10720 1016998001272 DNA replication initiation factor; Provisional; Region: PRK08084 1016998001273 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1016998001274 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1016998001275 ArsC family; Region: ArsC; pfam03960 1016998001276 catalytic residues [active] 1016998001277 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1016998001278 Peptidase family M48; Region: Peptidase_M48; cl12018 1016998001279 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1016998001280 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1016998001281 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1016998001282 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1016998001283 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1016998001284 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1016998001285 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1016998001286 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1016998001287 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1016998001288 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1016998001289 catalytic triad [active] 1016998001290 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 1016998001291 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 1016998001292 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1016998001293 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1016998001294 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1016998001295 dimer interface [polypeptide binding]; other site 1016998001296 active site 1016998001297 catalytic residue [active] 1016998001298 lipoprotein; Provisional; Region: PRK11679 1016998001299 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 1016998001300 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1016998001301 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1016998001302 ATP binding site [chemical binding]; other site 1016998001303 active site 1016998001304 substrate binding site [chemical binding]; other site 1016998001305 Predicted metalloprotease [General function prediction only]; Region: COG2321 1016998001306 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1016998001307 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 1016998001308 Helicase; Region: Helicase_RecD; pfam05127 1016998001309 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1016998001310 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 1016998001311 hypothetical protein; Provisional; Region: PRK13664 1016998001312 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1016998001313 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1016998001314 metal binding site [ion binding]; metal-binding site 1016998001315 dimer interface [polypeptide binding]; other site 1016998001316 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1016998001317 ArsC family; Region: ArsC; pfam03960 1016998001318 putative catalytic residues [active] 1016998001319 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 1016998001320 Protein export membrane protein; Region: SecD_SecF; cl14618 1016998001321 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 1016998001322 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1016998001323 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1016998001324 dimerization interface [polypeptide binding]; other site 1016998001325 Histidine kinase; Region: HisKA_3; pfam07730 1016998001326 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1016998001327 ATP binding site [chemical binding]; other site 1016998001328 Mg2+ binding site [ion binding]; other site 1016998001329 G-X-G motif; other site 1016998001330 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 1016998001331 4Fe-4S binding domain; Region: Fer4; pfam00037 1016998001332 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1016998001333 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1016998001334 putative periplasmic esterase; Provisional; Region: PRK03642 1016998001335 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1016998001336 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1016998001337 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1016998001338 dimer interface [polypeptide binding]; other site 1016998001339 ADP-ribose binding site [chemical binding]; other site 1016998001340 active site 1016998001341 nudix motif; other site 1016998001342 metal binding site [ion binding]; metal-binding site 1016998001343 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 1016998001344 transketolase; Reviewed; Region: PRK12753 1016998001345 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1016998001346 TPP-binding site [chemical binding]; other site 1016998001347 dimer interface [polypeptide binding]; other site 1016998001348 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1016998001349 PYR/PP interface [polypeptide binding]; other site 1016998001350 dimer interface [polypeptide binding]; other site 1016998001351 TPP binding site [chemical binding]; other site 1016998001352 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1016998001353 transaldolase-like protein; Provisional; Region: PTZ00411 1016998001354 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1016998001355 active site 1016998001356 dimer interface [polypeptide binding]; other site 1016998001357 catalytic residue [active] 1016998001358 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1016998001359 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1016998001360 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1016998001361 putative NAD(P) binding site [chemical binding]; other site 1016998001362 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1016998001363 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 1016998001364 putative hexamer interface [polypeptide binding]; other site 1016998001365 putative hexagonal pore; other site 1016998001366 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1016998001367 G1 box; other site 1016998001368 GTP/Mg2+ binding site [chemical binding]; other site 1016998001369 G2 box; other site 1016998001370 Switch I region; other site 1016998001371 G3 box; other site 1016998001372 Switch II region; other site 1016998001373 G4 box; other site 1016998001374 G5 box; other site 1016998001375 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 1016998001376 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 1016998001377 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 1016998001378 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1016998001379 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1016998001380 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 1016998001381 Hexamer interface [polypeptide binding]; other site 1016998001382 Putative hexagonal pore residue; other site 1016998001383 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1016998001384 Hexamer/Pentamer interface [polypeptide binding]; other site 1016998001385 central pore; other site 1016998001386 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 1016998001387 putative catalytic cysteine [active] 1016998001388 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 1016998001389 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1016998001390 nucleotide binding site [chemical binding]; other site 1016998001391 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 1016998001392 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 1016998001393 active site 1016998001394 metal binding site [ion binding]; metal-binding site 1016998001395 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 1016998001396 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 1016998001397 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 1016998001398 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1016998001399 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 1016998001400 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 1016998001401 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 1016998001402 putative hexamer interface [polypeptide binding]; other site 1016998001403 putative hexagonal pore; other site 1016998001404 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 1016998001405 putative hexamer interface [polypeptide binding]; other site 1016998001406 putative hexagonal pore; other site 1016998001407 carboxysome structural protein EutK; Provisional; Region: PRK15466 1016998001408 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1016998001409 Hexamer interface [polypeptide binding]; other site 1016998001410 Hexagonal pore residue; other site 1016998001411 transcriptional regulator EutR; Provisional; Region: PRK10130 1016998001412 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1016998001413 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1016998001414 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1016998001415 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1016998001416 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 1016998001417 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1016998001418 active site 1016998001419 metal binding site [ion binding]; metal-binding site 1016998001420 putative acetyltransferase; Provisional; Region: PRK03624 1016998001421 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1016998001422 Coenzyme A binding pocket [chemical binding]; other site 1016998001423 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 1016998001424 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 1016998001425 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 1016998001426 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1016998001427 short chain dehydrogenase; Provisional; Region: PRK08226 1016998001428 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 1016998001429 NAD binding site [chemical binding]; other site 1016998001430 homotetramer interface [polypeptide binding]; other site 1016998001431 homodimer interface [polypeptide binding]; other site 1016998001432 active site 1016998001433 thiosulfate transporter subunit; Provisional; Region: PRK10852 1016998001434 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1016998001435 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1016998001436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998001437 dimer interface [polypeptide binding]; other site 1016998001438 conserved gate region; other site 1016998001439 putative PBP binding loops; other site 1016998001440 ABC-ATPase subunit interface; other site 1016998001441 sulfate transport protein; Provisional; Region: cysT; CHL00187 1016998001442 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998001443 dimer interface [polypeptide binding]; other site 1016998001444 conserved gate region; other site 1016998001445 putative PBP binding loops; other site 1016998001446 ABC-ATPase subunit interface; other site 1016998001447 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 1016998001448 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1016998001449 Walker A/P-loop; other site 1016998001450 ATP binding site [chemical binding]; other site 1016998001451 Q-loop/lid; other site 1016998001452 ABC transporter signature motif; other site 1016998001453 Walker B; other site 1016998001454 D-loop; other site 1016998001455 H-loop/switch region; other site 1016998001456 TOBE-like domain; Region: TOBE_3; pfam12857 1016998001457 cysteine synthase B; Region: cysM; TIGR01138 1016998001458 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1016998001459 dimer interface [polypeptide binding]; other site 1016998001460 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998001461 catalytic residue [active] 1016998001462 Transglycosylase; Region: Transgly; cl17702 1016998001463 hypothetical protein; Provisional; Region: PRK10318 1016998001464 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1016998001465 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1016998001466 catalytic triad [active] 1016998001467 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 1016998001468 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1016998001469 DNA-binding site [nucleotide binding]; DNA binding site 1016998001470 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1016998001471 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998001472 homodimer interface [polypeptide binding]; other site 1016998001473 catalytic residue [active] 1016998001474 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1016998001475 dimer interface [polypeptide binding]; other site 1016998001476 pyridoxamine kinase; Validated; Region: PRK05756 1016998001477 pyridoxal binding site [chemical binding]; other site 1016998001478 ATP binding site [chemical binding]; other site 1016998001479 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1016998001480 HPr interaction site; other site 1016998001481 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1016998001482 active site 1016998001483 phosphorylation site [posttranslational modification] 1016998001484 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 1016998001485 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1016998001486 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1016998001487 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1016998001488 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1016998001489 dimerization domain swap beta strand [polypeptide binding]; other site 1016998001490 regulatory protein interface [polypeptide binding]; other site 1016998001491 active site 1016998001492 regulatory phosphorylation site [posttranslational modification]; other site 1016998001493 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1016998001494 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1016998001495 dimer interface [polypeptide binding]; other site 1016998001496 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998001497 catalytic residue [active] 1016998001498 putative sulfate transport protein CysZ; Validated; Region: PRK04949 1016998001499 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 1016998001500 cell division protein ZipA; Provisional; Region: PRK03427 1016998001501 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 1016998001502 FtsZ protein binding site [polypeptide binding]; other site 1016998001503 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1016998001504 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1016998001505 nucleotide binding pocket [chemical binding]; other site 1016998001506 K-X-D-G motif; other site 1016998001507 catalytic site [active] 1016998001508 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1016998001509 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1016998001510 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1016998001511 Dimer interface [polypeptide binding]; other site 1016998001512 BRCT sequence motif; other site 1016998001513 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 1016998001514 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1016998001515 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1016998001516 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1016998001517 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998001518 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1016998001519 putative dimerization interface [polypeptide binding]; other site 1016998001520 hypothetical protein; Provisional; Region: PRK11528 1016998001521 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1016998001522 nucleoside transporter; Region: 2A0110; TIGR00889 1016998001523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998001524 putative substrate translocation pore; other site 1016998001525 XapX domain; Region: XapX; TIGR03510 1016998001526 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1016998001527 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998001528 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 1016998001529 putative dimerization interface [polypeptide binding]; other site 1016998001530 putative substrate binding pocket [chemical binding]; other site 1016998001531 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1016998001532 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1016998001533 active site 1016998001534 HIGH motif; other site 1016998001535 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1016998001536 active site 1016998001537 KMSKS motif; other site 1016998001538 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 1016998001539 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 1016998001540 MASE1; Region: MASE1; pfam05231 1016998001541 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1016998001542 diguanylate cyclase; Region: GGDEF; smart00267 1016998001543 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1016998001544 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1016998001545 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1016998001546 Nucleoside recognition; Region: Gate; pfam07670 1016998001547 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1016998001548 manganese transport protein MntH; Reviewed; Region: PRK00701 1016998001549 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1016998001550 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 1016998001551 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1016998001552 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1016998001553 active site 1016998001554 catalytic tetrad [active] 1016998001555 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 1016998001556 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1016998001557 dimer interface [polypeptide binding]; other site 1016998001558 PYR/PP interface [polypeptide binding]; other site 1016998001559 TPP binding site [chemical binding]; other site 1016998001560 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1016998001561 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1016998001562 TPP-binding site [chemical binding]; other site 1016998001563 dimer interface [polypeptide binding]; other site 1016998001564 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1016998001565 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1016998001566 Cl- selectivity filter; other site 1016998001567 Cl- binding residues [ion binding]; other site 1016998001568 pore gating glutamate residue; other site 1016998001569 dimer interface [polypeptide binding]; other site 1016998001570 glucokinase; Provisional; Region: glk; PRK00292 1016998001571 glucokinase, proteobacterial type; Region: glk; TIGR00749 1016998001572 aminotransferase; Validated; Region: PRK08175 1016998001573 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1016998001574 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998001575 homodimer interface [polypeptide binding]; other site 1016998001576 catalytic residue [active] 1016998001577 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1016998001578 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1016998001579 putative acyl-acceptor binding pocket; other site 1016998001580 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 1016998001581 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1016998001582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998001583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998001584 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1016998001585 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1016998001586 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 1016998001587 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1016998001588 dimerization interface [polypeptide binding]; other site 1016998001589 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1016998001590 dimer interface [polypeptide binding]; other site 1016998001591 phosphorylation site [posttranslational modification] 1016998001592 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1016998001593 ATP binding site [chemical binding]; other site 1016998001594 Mg2+ binding site [ion binding]; other site 1016998001595 G-X-G motif; other site 1016998001596 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1016998001597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1016998001598 active site 1016998001599 phosphorylation site [posttranslational modification] 1016998001600 intermolecular recognition site; other site 1016998001601 dimerization interface [polypeptide binding]; other site 1016998001602 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1016998001603 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1016998001604 outer membrane protease; Reviewed; Region: PRK10993 1016998001605 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1016998001606 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 1016998001607 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 1016998001608 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 1016998001609 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 1016998001610 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1016998001611 dimer interface [polypeptide binding]; other site 1016998001612 active site 1016998001613 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1016998001614 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1016998001615 substrate binding site [chemical binding]; other site 1016998001616 oxyanion hole (OAH) forming residues; other site 1016998001617 trimer interface [polypeptide binding]; other site 1016998001618 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1016998001619 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1016998001620 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1016998001621 catalytic core [active] 1016998001622 hypothetical protein; Provisional; Region: PRK04946 1016998001623 Smr domain; Region: Smr; pfam01713 1016998001624 HemK family putative methylases; Region: hemK_fam; TIGR00536 1016998001625 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1016998001626 S-adenosylmethionine binding site [chemical binding]; other site 1016998001627 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1016998001628 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1016998001629 Tetramer interface [polypeptide binding]; other site 1016998001630 active site 1016998001631 FMN-binding site [chemical binding]; other site 1016998001632 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 1016998001633 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 1016998001634 hypothetical protein; Provisional; Region: PRK10621 1016998001635 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1016998001636 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 1016998001637 YfcL protein; Region: YfcL; pfam08891 1016998001638 Uncharacterized conserved protein [Function unknown]; Region: COG4121 1016998001639 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 1016998001640 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1016998001641 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1016998001642 dimer interface [polypeptide binding]; other site 1016998001643 active site 1016998001644 CAAX protease self-immunity; Region: Abi; pfam02517 1016998001645 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 1016998001646 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1016998001647 non-specific DNA binding site [nucleotide binding]; other site 1016998001648 salt bridge; other site 1016998001649 sequence-specific DNA binding site [nucleotide binding]; other site 1016998001650 putative transporter; Provisional; Region: PRK12382 1016998001651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998001652 putative substrate translocation pore; other site 1016998001653 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 1016998001654 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 1016998001655 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 1016998001656 ligand binding site [chemical binding]; other site 1016998001657 NAD binding site [chemical binding]; other site 1016998001658 catalytic site [active] 1016998001659 homodimer interface [polypeptide binding]; other site 1016998001660 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 1016998001661 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1016998001662 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 1016998001663 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1016998001664 dimerization interface 3.5A [polypeptide binding]; other site 1016998001665 active site 1016998001666 hypothetical protein; Provisional; Region: PRK10847 1016998001667 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1016998001668 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1016998001669 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 1016998001670 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1016998001671 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1016998001672 cell division protein DedD; Provisional; Region: PRK11633 1016998001673 Sporulation related domain; Region: SPOR; pfam05036 1016998001674 colicin V production protein; Provisional; Region: PRK10845 1016998001675 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1016998001676 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1016998001677 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1016998001678 active site 1016998001679 tetramer interface [polypeptide binding]; other site 1016998001680 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1016998001681 active site 1016998001682 PAS fold; Region: PAS_4; pfam08448 1016998001683 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1016998001684 putative active site [active] 1016998001685 heme pocket [chemical binding]; other site 1016998001686 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1016998001687 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1016998001688 Walker A motif; other site 1016998001689 ATP binding site [chemical binding]; other site 1016998001690 Walker B motif; other site 1016998001691 arginine finger; other site 1016998001692 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1016998001693 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1016998001694 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1016998001695 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1016998001696 catalytic residue [active] 1016998001697 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 1016998001698 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 1016998001699 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 1016998001700 dimer interface [polypeptide binding]; other site 1016998001701 active site 1016998001702 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1016998001703 substrate binding site [chemical binding]; other site 1016998001704 catalytic residue [active] 1016998001705 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1016998001706 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 1016998001707 Flavoprotein; Region: Flavoprotein; pfam02441 1016998001708 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 1016998001709 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1016998001710 substrate binding pocket [chemical binding]; other site 1016998001711 membrane-bound complex binding site; other site 1016998001712 hinge residues; other site 1016998001713 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 1016998001714 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1016998001715 substrate binding pocket [chemical binding]; other site 1016998001716 membrane-bound complex binding site; other site 1016998001717 hinge residues; other site 1016998001718 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1016998001719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998001720 dimer interface [polypeptide binding]; other site 1016998001721 conserved gate region; other site 1016998001722 putative PBP binding loops; other site 1016998001723 ABC-ATPase subunit interface; other site 1016998001724 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1016998001725 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998001726 dimer interface [polypeptide binding]; other site 1016998001727 conserved gate region; other site 1016998001728 putative PBP binding loops; other site 1016998001729 ABC-ATPase subunit interface; other site 1016998001730 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 1016998001731 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1016998001732 Walker A/P-loop; other site 1016998001733 ATP binding site [chemical binding]; other site 1016998001734 Q-loop/lid; other site 1016998001735 ABC transporter signature motif; other site 1016998001736 Walker B; other site 1016998001737 D-loop; other site 1016998001738 H-loop/switch region; other site 1016998001739 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1016998001740 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1016998001741 putative NAD(P) binding site [chemical binding]; other site 1016998001742 putative active site [active] 1016998001743 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1016998001744 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1016998001745 C-terminal domain interface [polypeptide binding]; other site 1016998001746 GSH binding site (G-site) [chemical binding]; other site 1016998001747 dimer interface [polypeptide binding]; other site 1016998001748 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1016998001749 N-terminal domain interface [polypeptide binding]; other site 1016998001750 putative dimer interface [polypeptide binding]; other site 1016998001751 active site 1016998001752 glutathione S-transferase; Provisional; Region: PRK15113 1016998001753 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1016998001754 C-terminal domain interface [polypeptide binding]; other site 1016998001755 GSH binding site (G-site) [chemical binding]; other site 1016998001756 dimer interface [polypeptide binding]; other site 1016998001757 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 1016998001758 N-terminal domain interface [polypeptide binding]; other site 1016998001759 putative dimer interface [polypeptide binding]; other site 1016998001760 putative substrate binding pocket (H-site) [chemical binding]; other site 1016998001761 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1016998001762 active site 1016998001763 metal binding site [ion binding]; metal-binding site 1016998001764 homotetramer interface [polypeptide binding]; other site 1016998001765 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 1016998001766 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 1016998001767 nudix motif; other site 1016998001768 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1016998001769 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1016998001770 DNA binding site [nucleotide binding] 1016998001771 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1016998001772 putative dimerization interface [polypeptide binding]; other site 1016998001773 putative ligand binding site [chemical binding]; other site 1016998001774 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1016998001775 active site 1016998001776 phosphorylation site [posttranslational modification] 1016998001777 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1016998001778 active site 1016998001779 P-loop; other site 1016998001780 phosphorylation site [posttranslational modification] 1016998001781 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK12996 1016998001782 transketolase; Reviewed; Region: PRK05899 1016998001783 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1016998001784 TPP-binding site [chemical binding]; other site 1016998001785 dimer interface [polypeptide binding]; other site 1016998001786 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1016998001787 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1016998001788 PYR/PP interface [polypeptide binding]; other site 1016998001789 dimer interface [polypeptide binding]; other site 1016998001790 TPP binding site [chemical binding]; other site 1016998001791 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1016998001792 hypothetical protein; Provisional; Region: PRK11588 1016998001793 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1016998001794 phosphate acetyltransferase; Reviewed; Region: PRK05632 1016998001795 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1016998001796 DRTGG domain; Region: DRTGG; pfam07085 1016998001797 phosphate acetyltransferase; Region: pta; TIGR00651 1016998001798 propionate/acetate kinase; Provisional; Region: PRK12379 1016998001799 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1016998001800 hypothetical protein; Provisional; Region: PRK01816 1016998001801 hypothetical protein; Validated; Region: PRK05445 1016998001802 putative phosphatase; Provisional; Region: PRK11587 1016998001803 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1016998001804 motif II; other site 1016998001805 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1016998001806 transmembrane helices; other site 1016998001807 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1016998001808 TrkA-C domain; Region: TrkA_C; pfam02080 1016998001809 TrkA-C domain; Region: TrkA_C; pfam02080 1016998001810 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1016998001811 5'-nucleotidase; Provisional; Region: PRK03826 1016998001812 aminotransferase AlaT; Validated; Region: PRK09265 1016998001813 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1016998001814 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998001815 homodimer interface [polypeptide binding]; other site 1016998001816 catalytic residue [active] 1016998001817 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 1016998001818 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998001819 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 1016998001820 putative dimerization interface [polypeptide binding]; other site 1016998001821 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1016998001822 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 1016998001823 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 1016998001824 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1016998001825 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1016998001826 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1016998001827 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1016998001828 putative dimer interface [polypeptide binding]; other site 1016998001829 [2Fe-2S] cluster binding site [ion binding]; other site 1016998001830 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 1016998001831 SLBB domain; Region: SLBB; pfam10531 1016998001832 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1016998001833 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 1016998001834 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1016998001835 catalytic loop [active] 1016998001836 iron binding site [ion binding]; other site 1016998001837 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1016998001838 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1016998001839 [4Fe-4S] binding site [ion binding]; other site 1016998001840 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1016998001841 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1016998001842 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1016998001843 4Fe-4S binding domain; Region: Fer4; pfam00037 1016998001844 4Fe-4S binding domain; Region: Fer4; pfam00037 1016998001845 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1016998001846 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1016998001847 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1016998001848 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1016998001849 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1016998001850 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1016998001851 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1016998001852 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1016998001853 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1016998001854 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1016998001855 von Willebrand factor; Region: vWF_A; pfam12450 1016998001856 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1016998001857 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 1016998001858 metal ion-dependent adhesion site (MIDAS); other site 1016998001859 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 1016998001860 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1016998001861 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1016998001862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1016998001863 active site 1016998001864 phosphorylation site [posttranslational modification] 1016998001865 intermolecular recognition site; other site 1016998001866 dimerization interface [polypeptide binding]; other site 1016998001867 ribonuclease BN; Region: true_RNase_BN; TIGR02649 1016998001868 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1016998001869 Coenzyme A binding pocket [chemical binding]; other site 1016998001870 hypothetical protein; Provisional; Region: PRK10404 1016998001871 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 1016998001872 isochorismate synthases; Region: isochor_syn; TIGR00543 1016998001873 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1016998001874 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1016998001875 dimer interface [polypeptide binding]; other site 1016998001876 tetramer interface [polypeptide binding]; other site 1016998001877 PYR/PP interface [polypeptide binding]; other site 1016998001878 TPP binding site [chemical binding]; other site 1016998001879 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1016998001880 TPP-binding site; other site 1016998001881 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 1016998001882 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1016998001883 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1016998001884 substrate binding site [chemical binding]; other site 1016998001885 oxyanion hole (OAH) forming residues; other site 1016998001886 trimer interface [polypeptide binding]; other site 1016998001887 O-succinylbenzoate synthase [Coenzyme metabolism]; Region: MenC; COG1441 1016998001888 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1016998001889 active site 1016998001890 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 1016998001891 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1016998001892 acyl-activating enzyme (AAE) consensus motif; other site 1016998001893 putative AMP binding site [chemical binding]; other site 1016998001894 putative active site [active] 1016998001895 putative CoA binding site [chemical binding]; other site 1016998001896 signal transduction protein PmrD; Provisional; Region: PRK15450 1016998001897 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 1016998001898 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 1016998001899 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 1016998001900 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1016998001901 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 1016998001902 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 1016998001903 putative active site [active] 1016998001904 putative catalytic site [active] 1016998001905 putative Zn binding site [ion binding]; other site 1016998001906 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 1016998001907 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1016998001908 active site 1016998001909 substrate binding site [chemical binding]; other site 1016998001910 cosubstrate binding site; other site 1016998001911 catalytic site [active] 1016998001912 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 1016998001913 active site 1016998001914 hexamer interface [polypeptide binding]; other site 1016998001915 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 1016998001916 NAD binding site [chemical binding]; other site 1016998001917 substrate binding site [chemical binding]; other site 1016998001918 active site 1016998001919 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1016998001920 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1016998001921 Ligand binding site; other site 1016998001922 Putative Catalytic site; other site 1016998001923 DXD motif; other site 1016998001924 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1016998001925 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1016998001926 inhibitor-cofactor binding pocket; inhibition site 1016998001927 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998001928 catalytic residue [active] 1016998001929 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1016998001930 catalytic core [active] 1016998001931 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 1016998001932 YfaZ precursor; Region: YfaZ; pfam07437 1016998001933 hypothetical protein; Provisional; Region: PRK03673 1016998001934 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1016998001935 putative MPT binding site; other site 1016998001936 Competence-damaged protein; Region: CinA; cl00666 1016998001937 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1016998001938 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1016998001939 Bacterial transcriptional regulator; Region: IclR; pfam01614 1016998001940 L-rhamnonate dehydratase; Provisional; Region: PRK15440 1016998001941 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 1016998001942 putative active site pocket [active] 1016998001943 putative metal binding site [ion binding]; other site 1016998001944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998001945 D-galactonate transporter; Region: 2A0114; TIGR00893 1016998001946 putative substrate translocation pore; other site 1016998001947 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 1016998001948 hypothetical protein; Provisional; Region: PRK03673 1016998001949 deubiquitinase SseL; Provisional; Region: PRK14848 1016998001950 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 1016998001951 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1016998001952 Cysteine-rich domain; Region: CCG; pfam02754 1016998001953 Cysteine-rich domain; Region: CCG; pfam02754 1016998001954 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 1016998001955 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 1016998001956 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 1016998001957 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1016998001958 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1016998001959 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1016998001960 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998001961 putative substrate translocation pore; other site 1016998001962 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 1016998001963 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 1016998001964 active site 1016998001965 catalytic site [active] 1016998001966 metal binding site [ion binding]; metal-binding site 1016998001967 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1016998001968 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998001969 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1016998001970 dimerization interface [polypeptide binding]; other site 1016998001971 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1016998001972 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998001973 putative substrate translocation pore; other site 1016998001974 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1016998001975 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1016998001976 catalytic loop [active] 1016998001977 iron binding site [ion binding]; other site 1016998001978 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1016998001979 dimer interface [polypeptide binding]; other site 1016998001980 putative radical transfer pathway; other site 1016998001981 diiron center [ion binding]; other site 1016998001982 tyrosyl radical; other site 1016998001983 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 1016998001984 ATP cone domain; Region: ATP-cone; pfam03477 1016998001985 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1016998001986 active site 1016998001987 dimer interface [polypeptide binding]; other site 1016998001988 catalytic residues [active] 1016998001989 effector binding site; other site 1016998001990 R2 peptide binding site; other site 1016998001991 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1016998001992 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1016998001993 S-adenosylmethionine binding site [chemical binding]; other site 1016998001994 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1016998001995 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1016998001996 DNA-binding site [nucleotide binding]; DNA binding site 1016998001997 FCD domain; Region: FCD; pfam07729 1016998001998 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1016998001999 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998002000 putative substrate translocation pore; other site 1016998002001 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1016998002002 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1016998002003 active site pocket [active] 1016998002004 DNA gyrase subunit A; Validated; Region: PRK05560 1016998002005 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1016998002006 CAP-like domain; other site 1016998002007 active site 1016998002008 primary dimer interface [polypeptide binding]; other site 1016998002009 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1016998002010 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1016998002011 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1016998002012 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1016998002013 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1016998002014 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1016998002015 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 1016998002016 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1016998002017 dimer interface [polypeptide binding]; other site 1016998002018 phosphorylation site [posttranslational modification] 1016998002019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1016998002020 ATP binding site [chemical binding]; other site 1016998002021 Mg2+ binding site [ion binding]; other site 1016998002022 G-X-G motif; other site 1016998002023 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 1016998002024 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1016998002025 active site 1016998002026 phosphorylation site [posttranslational modification] 1016998002027 intermolecular recognition site; other site 1016998002028 dimerization interface [polypeptide binding]; other site 1016998002029 transcriptional regulator RcsB; Provisional; Region: PRK10840 1016998002030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1016998002031 active site 1016998002032 phosphorylation site [posttranslational modification] 1016998002033 intermolecular recognition site; other site 1016998002034 dimerization interface [polypeptide binding]; other site 1016998002035 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1016998002036 DNA binding residues [nucleotide binding] 1016998002037 dimerization interface [polypeptide binding]; other site 1016998002038 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 1016998002039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1016998002040 ATP binding site [chemical binding]; other site 1016998002041 G-X-G motif; other site 1016998002042 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1016998002043 putative binding surface; other site 1016998002044 active site 1016998002045 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1016998002046 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1016998002047 trimer interface [polypeptide binding]; other site 1016998002048 eyelet of channel; other site 1016998002049 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 1016998002050 ApbE family; Region: ApbE; pfam02424 1016998002051 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 1016998002052 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1016998002053 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1016998002054 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1016998002055 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1016998002056 DNA binding site [nucleotide binding] 1016998002057 active site 1016998002058 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 1016998002059 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 1016998002060 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1016998002061 Walker A/P-loop; other site 1016998002062 ATP binding site [chemical binding]; other site 1016998002063 Q-loop/lid; other site 1016998002064 ABC transporter signature motif; other site 1016998002065 Walker B; other site 1016998002066 D-loop; other site 1016998002067 H-loop/switch region; other site 1016998002068 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 1016998002069 secondary substrate binding site; other site 1016998002070 primary substrate binding site; other site 1016998002071 inhibition loop; other site 1016998002072 dimerization interface [polypeptide binding]; other site 1016998002073 ferredoxin-type protein; Provisional; Region: PRK10194 1016998002074 4Fe-4S binding domain; Region: Fer4; cl02805 1016998002075 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 1016998002076 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 1016998002077 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1016998002078 [4Fe-4S] binding site [ion binding]; other site 1016998002079 molybdopterin cofactor binding site; other site 1016998002080 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1016998002081 molybdopterin cofactor binding site; other site 1016998002082 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 1016998002083 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 1016998002084 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1016998002085 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1016998002086 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 1016998002087 cytochrome c-type protein NapC; Provisional; Region: PRK10617 1016998002088 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 1016998002089 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 1016998002090 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1016998002091 Walker A/P-loop; other site 1016998002092 ATP binding site [chemical binding]; other site 1016998002093 Q-loop/lid; other site 1016998002094 ABC transporter signature motif; other site 1016998002095 Walker B; other site 1016998002096 D-loop; other site 1016998002097 H-loop/switch region; other site 1016998002098 heme exporter protein CcmB; Region: ccmB; TIGR01190 1016998002099 heme exporter protein CcmC; Region: ccmC; TIGR01191 1016998002100 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 1016998002101 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150 1016998002102 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 1016998002103 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 1016998002104 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1016998002105 catalytic residues [active] 1016998002106 central insert; other site 1016998002107 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 1016998002108 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 1016998002109 transcriptional regulator NarP; Provisional; Region: PRK10403 1016998002110 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1016998002111 active site 1016998002112 phosphorylation site [posttranslational modification] 1016998002113 intermolecular recognition site; other site 1016998002114 dimerization interface [polypeptide binding]; other site 1016998002115 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1016998002116 DNA binding residues [nucleotide binding] 1016998002117 dimerization interface [polypeptide binding]; other site 1016998002118 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 1016998002119 DinI-like family; Region: DinI; cl11630 1016998002120 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1016998002121 E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387 1016998002122 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 1016998002123 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 1016998002124 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1016998002125 Leucine-rich repeats; other site 1016998002126 Substrate binding site [chemical binding]; other site 1016998002127 Protein of unknown function (DUF968); Region: DUF968; pfam06147 1016998002128 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 1016998002129 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 1016998002130 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 1016998002131 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 1016998002132 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1016998002133 Phage head maturation protease [General function prediction only]; Region: COG3740 1016998002134 Phage T4 tail fibre; Region: Phage_T4_gp36; pfam03903 1016998002135 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1016998002136 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1016998002137 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1016998002138 DinI-like family; Region: DinI; cl11630 1016998002139 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1016998002140 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1016998002141 Catalytic site [active] 1016998002142 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 1016998002143 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 1016998002144 Sulfatase; Region: Sulfatase; cl17466 1016998002145 hypothetical protein; Provisional; Region: PRK13689 1016998002146 Nucleoid-associated protein [General function prediction only]; Region: COG3081 1016998002147 nucleoid-associated protein NdpA; Validated; Region: PRK00378 1016998002148 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1016998002149 5S rRNA interface [nucleotide binding]; other site 1016998002150 CTC domain interface [polypeptide binding]; other site 1016998002151 L16 interface [polypeptide binding]; other site 1016998002152 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1016998002153 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1016998002154 ATP binding site [chemical binding]; other site 1016998002155 putative Mg++ binding site [ion binding]; other site 1016998002156 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1016998002157 nucleotide binding region [chemical binding]; other site 1016998002158 ATP-binding site [chemical binding]; other site 1016998002159 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 1016998002160 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 1016998002161 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1016998002162 RNA binding surface [nucleotide binding]; other site 1016998002163 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1016998002164 active site 1016998002165 uracil binding [chemical binding]; other site 1016998002166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998002167 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1016998002168 putative substrate translocation pore; other site 1016998002169 hypothetical protein; Provisional; Region: PRK11835 1016998002170 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 1016998002171 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1016998002172 Walker A/P-loop; other site 1016998002173 ATP binding site [chemical binding]; other site 1016998002174 Q-loop/lid; other site 1016998002175 ABC transporter signature motif; other site 1016998002176 Walker B; other site 1016998002177 D-loop; other site 1016998002178 H-loop/switch region; other site 1016998002179 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1016998002180 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1016998002181 Walker A/P-loop; other site 1016998002182 ATP binding site [chemical binding]; other site 1016998002183 Q-loop/lid; other site 1016998002184 ABC transporter signature motif; other site 1016998002185 Walker B; other site 1016998002186 D-loop; other site 1016998002187 H-loop/switch region; other site 1016998002188 microcin C ABC transporter permease; Provisional; Region: PRK15021 1016998002189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998002190 dimer interface [polypeptide binding]; other site 1016998002191 conserved gate region; other site 1016998002192 ABC-ATPase subunit interface; other site 1016998002193 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1016998002194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998002195 dimer interface [polypeptide binding]; other site 1016998002196 conserved gate region; other site 1016998002197 putative PBP binding loops; other site 1016998002198 ABC-ATPase subunit interface; other site 1016998002199 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1016998002200 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1016998002201 phage resistance protein; Provisional; Region: PRK10551 1016998002202 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1016998002203 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1016998002204 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 1016998002205 NlpC/P60 family; Region: NLPC_P60; pfam00877 1016998002206 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1016998002207 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1016998002208 active site 1016998002209 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1016998002210 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1016998002211 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1016998002212 elongation factor P; Provisional; Region: PRK04542 1016998002213 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1016998002214 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1016998002215 RNA binding site [nucleotide binding]; other site 1016998002216 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1016998002217 RNA binding site [nucleotide binding]; other site 1016998002218 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1016998002219 sugar efflux transporter B; Provisional; Region: PRK15011 1016998002220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998002221 putative substrate translocation pore; other site 1016998002222 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 1016998002223 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1016998002224 active site 1016998002225 phosphorylation site [posttranslational modification] 1016998002226 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1016998002227 dimerization domain swap beta strand [polypeptide binding]; other site 1016998002228 regulatory protein interface [polypeptide binding]; other site 1016998002229 active site 1016998002230 regulatory phosphorylation site [posttranslational modification]; other site 1016998002231 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1016998002232 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1016998002233 putative substrate binding site [chemical binding]; other site 1016998002234 putative ATP binding site [chemical binding]; other site 1016998002235 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 1016998002236 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 1016998002237 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1016998002238 active site 1016998002239 P-loop; other site 1016998002240 phosphorylation site [posttranslational modification] 1016998002241 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 1016998002242 endonuclease IV; Provisional; Region: PRK01060 1016998002243 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1016998002244 AP (apurinic/apyrimidinic) site pocket; other site 1016998002245 DNA interaction; other site 1016998002246 Metal-binding active site; metal-binding site 1016998002247 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1016998002248 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1016998002249 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998002250 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1016998002251 putative dimerization interface [polypeptide binding]; other site 1016998002252 lysine transporter; Provisional; Region: PRK10836 1016998002253 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 1016998002254 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1016998002255 N-terminal plug; other site 1016998002256 ligand-binding site [chemical binding]; other site 1016998002257 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1016998002258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998002259 putative substrate translocation pore; other site 1016998002260 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1016998002261 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1016998002262 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1016998002263 motif II; other site 1016998002264 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1016998002265 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1016998002266 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1016998002267 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1016998002268 non-specific DNA binding site [nucleotide binding]; other site 1016998002269 salt bridge; other site 1016998002270 sequence-specific DNA binding site [nucleotide binding]; other site 1016998002271 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1016998002272 S-formylglutathione hydrolase; Region: PLN02442 1016998002273 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1016998002274 GTP cyclohydrolase I; Provisional; Region: PLN03044 1016998002275 active site 1016998002276 Predicted membrane protein [Function unknown]; Region: COG2311 1016998002277 hypothetical protein; Provisional; Region: PRK10835 1016998002278 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 1016998002279 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1016998002280 DNA binding site [nucleotide binding] 1016998002281 domain linker motif; other site 1016998002282 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1016998002283 dimerization interface (closed form) [polypeptide binding]; other site 1016998002284 ligand binding site [chemical binding]; other site 1016998002285 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 1016998002286 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 1016998002287 ligand binding site [chemical binding]; other site 1016998002288 calcium binding site [ion binding]; other site 1016998002289 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1016998002290 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 1016998002291 Walker A/P-loop; other site 1016998002292 ATP binding site [chemical binding]; other site 1016998002293 Q-loop/lid; other site 1016998002294 ABC transporter signature motif; other site 1016998002295 Walker B; other site 1016998002296 D-loop; other site 1016998002297 H-loop/switch region; other site 1016998002298 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1016998002299 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1016998002300 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1016998002301 TM-ABC transporter signature motif; other site 1016998002302 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 1016998002303 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 1016998002304 homodimer interface [polypeptide binding]; other site 1016998002305 active site 1016998002306 FMN binding site [chemical binding]; other site 1016998002307 substrate binding site [chemical binding]; other site 1016998002308 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 1016998002309 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1016998002310 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1016998002311 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 1016998002312 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1016998002313 putative active site [active] 1016998002314 cytidine deaminase; Provisional; Region: PRK09027 1016998002315 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1016998002316 active site 1016998002317 catalytic motif [active] 1016998002318 Zn binding site [ion binding]; other site 1016998002319 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1016998002320 active site 1016998002321 catalytic motif [active] 1016998002322 Zn binding site [ion binding]; other site 1016998002323 hypothetical protein; Provisional; Region: PRK10711 1016998002324 hypothetical protein; Provisional; Region: PRK01821 1016998002325 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1016998002326 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998002327 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1016998002328 dimerization interface [polypeptide binding]; other site 1016998002329 benzoate transport; Region: 2A0115; TIGR00895 1016998002330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998002331 putative substrate translocation pore; other site 1016998002332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998002333 putative substrate translocation pore; other site 1016998002334 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 1016998002335 Cupin domain; Region: Cupin_2; pfam07883 1016998002336 Cupin domain; Region: Cupin_2; pfam07883 1016998002337 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1016998002338 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1016998002339 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 1016998002340 maleylacetoacetate isomerase; Region: maiA; TIGR01262 1016998002341 C-terminal domain interface [polypeptide binding]; other site 1016998002342 GSH binding site (G-site) [chemical binding]; other site 1016998002343 putative dimer interface [polypeptide binding]; other site 1016998002344 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 1016998002345 dimer interface [polypeptide binding]; other site 1016998002346 N-terminal domain interface [polypeptide binding]; other site 1016998002347 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 1016998002348 salicylate hydroxylase; Provisional; Region: PRK08163 1016998002349 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1016998002350 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 1016998002351 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1016998002352 FMN binding site [chemical binding]; other site 1016998002353 active site 1016998002354 catalytic residues [active] 1016998002355 substrate binding site [chemical binding]; other site 1016998002356 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 1016998002357 oxidoreductase; Provisional; Region: PRK12743 1016998002358 classical (c) SDRs; Region: SDR_c; cd05233 1016998002359 NAD(P) binding site [chemical binding]; other site 1016998002360 active site 1016998002361 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1016998002362 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1016998002363 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 1016998002364 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 1016998002365 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1016998002366 D-lactate dehydrogenase; Provisional; Region: PRK11183 1016998002367 FAD binding domain; Region: FAD_binding_4; pfam01565 1016998002368 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 1016998002369 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1016998002370 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1016998002371 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1016998002372 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1016998002373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998002374 dimer interface [polypeptide binding]; other site 1016998002375 conserved gate region; other site 1016998002376 ABC-ATPase subunit interface; other site 1016998002377 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1016998002378 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1016998002379 Walker A/P-loop; other site 1016998002380 ATP binding site [chemical binding]; other site 1016998002381 Q-loop/lid; other site 1016998002382 ABC transporter signature motif; other site 1016998002383 Walker B; other site 1016998002384 D-loop; other site 1016998002385 H-loop/switch region; other site 1016998002386 CBS domain; Region: CBS; pfam00571 1016998002387 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1016998002388 putative PBP binding loops; other site 1016998002389 ABC-ATPase subunit interface; other site 1016998002390 hypothetical protein; Provisional; Region: PRK13681 1016998002391 transcriptional regulator MirA; Provisional; Region: PRK15043 1016998002392 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 1016998002393 DNA binding residues [nucleotide binding] 1016998002394 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1016998002395 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1016998002396 GAF domain; Region: GAF; pfam01590 1016998002397 Histidine kinase; Region: His_kinase; pfam06580 1016998002398 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1016998002399 ATP binding site [chemical binding]; other site 1016998002400 Mg2+ binding site [ion binding]; other site 1016998002401 G-X-G motif; other site 1016998002402 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 1016998002403 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1016998002404 active site 1016998002405 phosphorylation site [posttranslational modification] 1016998002406 intermolecular recognition site; other site 1016998002407 dimerization interface [polypeptide binding]; other site 1016998002408 LytTr DNA-binding domain; Region: LytTR; pfam04397 1016998002409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 1016998002410 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1016998002411 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1016998002412 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 1016998002413 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 1016998002414 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1016998002415 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1016998002416 active site 1016998002417 HIGH motif; other site 1016998002418 KMSKS motif; other site 1016998002419 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1016998002420 tRNA binding surface [nucleotide binding]; other site 1016998002421 anticodon binding site; other site 1016998002422 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1016998002423 dimer interface [polypeptide binding]; other site 1016998002424 putative tRNA-binding site [nucleotide binding]; other site 1016998002425 antiporter inner membrane protein; Provisional; Region: PRK11670 1016998002426 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1016998002427 Walker A motif; other site 1016998002428 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 1016998002429 fimbrial chaperone protein; Provisional; Region: PRK15220 1016998002430 putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253 1016998002431 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1016998002432 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1016998002433 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 1016998002434 PapC N-terminal domain; Region: PapC_N; pfam13954 1016998002435 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1016998002436 PapC C-terminal domain; Region: PapC_C; pfam13953 1016998002437 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 1016998002438 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 1016998002439 Predicted integral membrane protein [Function unknown]; Region: COG5455 1016998002440 TPP riboswitch (THI element) 1016998002441 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1016998002442 substrate binding site [chemical binding]; other site 1016998002443 multimerization interface [polypeptide binding]; other site 1016998002444 ATP binding site [chemical binding]; other site 1016998002445 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1016998002446 dimer interface [polypeptide binding]; other site 1016998002447 substrate binding site [chemical binding]; other site 1016998002448 ATP binding site [chemical binding]; other site 1016998002449 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1016998002450 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1016998002451 DNA-binding site [nucleotide binding]; DNA binding site 1016998002452 UTRA domain; Region: UTRA; pfam07702 1016998002453 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1016998002454 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1016998002455 substrate binding site [chemical binding]; other site 1016998002456 ATP binding site [chemical binding]; other site 1016998002457 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 1016998002458 nucleoside transporter; Region: 2A0110; TIGR00889 1016998002459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998002460 putative substrate translocation pore; other site 1016998002461 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 1016998002462 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1016998002463 putative active site; other site 1016998002464 catalytic residue [active] 1016998002465 lipid kinase; Reviewed; Region: PRK13054 1016998002466 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1016998002467 type III secretion system protein; Provisional; Region: PRK15383 1016998002468 non-LEE encoded effector protein NleB; Provisional; Region: PRK15382 1016998002469 putative protease; Provisional; Region: PRK15452 1016998002470 Peptidase family U32; Region: Peptidase_U32; pfam01136 1016998002471 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 1016998002472 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 1016998002473 PcfJ-like protein; Region: PcfJ; pfam14284 1016998002474 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 1016998002475 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1016998002476 active site 1016998002477 phosphorylation site [posttranslational modification] 1016998002478 intermolecular recognition site; other site 1016998002479 dimerization interface [polypeptide binding]; other site 1016998002480 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1016998002481 DNA binding site [nucleotide binding] 1016998002482 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 1016998002483 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1016998002484 dimerization interface [polypeptide binding]; other site 1016998002485 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1016998002486 dimer interface [polypeptide binding]; other site 1016998002487 phosphorylation site [posttranslational modification] 1016998002488 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1016998002489 ATP binding site [chemical binding]; other site 1016998002490 Mg2+ binding site [ion binding]; other site 1016998002491 G-X-G motif; other site 1016998002492 putative transporter; Provisional; Region: PRK10504 1016998002493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998002494 putative substrate translocation pore; other site 1016998002495 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1016998002496 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1016998002497 Protein export membrane protein; Region: SecD_SecF; cl14618 1016998002498 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 1016998002499 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1016998002500 HlyD family secretion protein; Region: HlyD_3; pfam13437 1016998002501 putative chaperone; Provisional; Region: PRK11678 1016998002502 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1016998002503 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1016998002504 nucleotide binding site [chemical binding]; other site 1016998002505 SBD interface [polypeptide binding]; other site 1016998002506 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 1016998002507 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1016998002508 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1016998002509 minor groove reading motif; other site 1016998002510 helix-hairpin-helix signature motif; other site 1016998002511 substrate binding pocket [chemical binding]; other site 1016998002512 active site 1016998002513 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 1016998002514 PAS domain S-box; Region: sensory_box; TIGR00229 1016998002515 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1016998002516 putative active site [active] 1016998002517 heme pocket [chemical binding]; other site 1016998002518 PAS domain S-box; Region: sensory_box; TIGR00229 1016998002519 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1016998002520 putative active site [active] 1016998002521 heme pocket [chemical binding]; other site 1016998002522 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1016998002523 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1016998002524 metal binding site [ion binding]; metal-binding site 1016998002525 active site 1016998002526 I-site; other site 1016998002527 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1016998002528 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1016998002529 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1016998002530 ATP-binding site [chemical binding]; other site 1016998002531 Sugar specificity; other site 1016998002532 Pyrimidine base specificity; other site 1016998002533 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1016998002534 trimer interface [polypeptide binding]; other site 1016998002535 active site 1016998002536 putative assembly protein; Provisional; Region: PRK10833 1016998002537 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1016998002538 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1016998002539 FOG: CBS domain [General function prediction only]; Region: COG0517 1016998002540 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1016998002541 Transporter associated domain; Region: CorC_HlyC; smart01091 1016998002542 polysaccharide export protein Wza; Provisional; Region: PRK15078 1016998002543 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1016998002544 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1016998002545 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1016998002546 active site 1016998002547 tyrosine kinase; Provisional; Region: PRK11519 1016998002548 Chain length determinant protein; Region: Wzz; pfam02706 1016998002549 Chain length determinant protein; Region: Wzz; cl15801 1016998002550 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1016998002551 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1016998002552 putative glycosyl transferase; Provisional; Region: PRK10018 1016998002553 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1016998002554 active site 1016998002555 putative acyl transferase; Provisional; Region: PRK10191 1016998002556 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1016998002557 trimer interface [polypeptide binding]; other site 1016998002558 active site 1016998002559 substrate binding site [chemical binding]; other site 1016998002560 CoA binding site [chemical binding]; other site 1016998002561 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1016998002562 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 1016998002563 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 1016998002564 putative glycosyl transferase; Provisional; Region: PRK10063 1016998002565 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1016998002566 metal-binding site 1016998002567 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 1016998002568 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 1016998002569 putative trimer interface [polypeptide binding]; other site 1016998002570 putative active site [active] 1016998002571 putative substrate binding site [chemical binding]; other site 1016998002572 putative CoA binding site [chemical binding]; other site 1016998002573 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1016998002574 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1016998002575 NADP-binding site; other site 1016998002576 homotetramer interface [polypeptide binding]; other site 1016998002577 substrate binding site [chemical binding]; other site 1016998002578 homodimer interface [polypeptide binding]; other site 1016998002579 active site 1016998002580 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1016998002581 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1016998002582 NADP binding site [chemical binding]; other site 1016998002583 active site 1016998002584 putative substrate binding site [chemical binding]; other site 1016998002585 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 1016998002586 active site 1016998002587 GDP-Mannose binding site [chemical binding]; other site 1016998002588 dimer interface [polypeptide binding]; other site 1016998002589 modified nudix motif 1016998002590 metal binding site [ion binding]; metal-binding site 1016998002591 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 1016998002592 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1016998002593 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 1016998002594 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1016998002595 Substrate binding site; other site 1016998002596 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1016998002597 phosphomannomutase CpsG; Provisional; Region: PRK15414 1016998002598 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1016998002599 active site 1016998002600 substrate binding site [chemical binding]; other site 1016998002601 metal binding site [ion binding]; metal-binding site 1016998002602 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 1016998002603 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1016998002604 colanic acid exporter; Provisional; Region: PRK10459 1016998002605 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1016998002606 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1016998002607 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 1016998002608 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 1016998002609 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 1016998002610 putative ADP-binding pocket [chemical binding]; other site 1016998002611 colanic acid biosynthesis protein WcaM; Region: WcaM; TIGR04004 1016998002612 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1016998002613 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1016998002614 active site 1016998002615 tetramer interface; other site 1016998002616 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 1016998002617 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1016998002618 NAD binding site [chemical binding]; other site 1016998002619 substrate binding site [chemical binding]; other site 1016998002620 homodimer interface [polypeptide binding]; other site 1016998002621 active site 1016998002622 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 1016998002623 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1016998002624 NADP binding site [chemical binding]; other site 1016998002625 active site 1016998002626 putative substrate binding site [chemical binding]; other site 1016998002627 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 1016998002628 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1016998002629 substrate binding site; other site 1016998002630 tetramer interface; other site 1016998002631 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1016998002632 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1016998002633 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1016998002634 catalytic loop [active] 1016998002635 iron binding site [ion binding]; other site 1016998002636 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1016998002637 FAD binding pocket [chemical binding]; other site 1016998002638 FAD binding motif [chemical binding]; other site 1016998002639 phosphate binding motif [ion binding]; other site 1016998002640 beta-alpha-beta structure motif; other site 1016998002641 NAD binding pocket [chemical binding]; other site 1016998002642 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1016998002643 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1016998002644 substrate binding site; other site 1016998002645 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 1016998002646 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 1016998002647 NAD binding site [chemical binding]; other site 1016998002648 homotetramer interface [polypeptide binding]; other site 1016998002649 homodimer interface [polypeptide binding]; other site 1016998002650 substrate binding site [chemical binding]; other site 1016998002651 active site 1016998002652 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 1016998002653 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1016998002654 inhibitor-cofactor binding pocket; inhibition site 1016998002655 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998002656 catalytic residue [active] 1016998002657 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1016998002658 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1016998002659 NAD(P) binding site [chemical binding]; other site 1016998002660 active site 1016998002661 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 1016998002662 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1016998002663 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1016998002664 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1016998002665 active site 1016998002666 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1016998002667 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1016998002668 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1016998002669 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1016998002670 active site 1016998002671 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1016998002672 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1016998002673 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1016998002674 Substrate binding site; other site 1016998002675 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1016998002676 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1016998002677 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 1016998002678 active site 1016998002679 substrate binding site [chemical binding]; other site 1016998002680 metal binding site [ion binding]; metal-binding site 1016998002681 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 1016998002682 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1016998002683 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1016998002684 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1016998002685 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1016998002686 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1016998002687 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 1016998002688 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1016998002689 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1016998002690 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1016998002691 chain length determinant protein WzzB; Provisional; Region: PRK15471 1016998002692 Chain length determinant protein; Region: Wzz; cl15801 1016998002693 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1016998002694 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1016998002695 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1016998002696 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1016998002697 metal binding site [ion binding]; metal-binding site 1016998002698 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1016998002699 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1016998002700 substrate binding site [chemical binding]; other site 1016998002701 glutamase interaction surface [polypeptide binding]; other site 1016998002702 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1016998002703 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1016998002704 catalytic residues [active] 1016998002705 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 1016998002706 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1016998002707 putative active site [active] 1016998002708 oxyanion strand; other site 1016998002709 catalytic triad [active] 1016998002710 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 1016998002711 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1016998002712 active site 1016998002713 motif I; other site 1016998002714 motif II; other site 1016998002715 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1016998002716 putative active site pocket [active] 1016998002717 4-fold oligomerization interface [polypeptide binding]; other site 1016998002718 metal binding residues [ion binding]; metal-binding site 1016998002719 3-fold/trimer interface [polypeptide binding]; other site 1016998002720 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 1016998002721 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1016998002722 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998002723 homodimer interface [polypeptide binding]; other site 1016998002724 catalytic residue [active] 1016998002725 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1016998002726 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1016998002727 NAD binding site [chemical binding]; other site 1016998002728 dimerization interface [polypeptide binding]; other site 1016998002729 product binding site; other site 1016998002730 substrate binding site [chemical binding]; other site 1016998002731 zinc binding site [ion binding]; other site 1016998002732 catalytic residues [active] 1016998002733 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1016998002734 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1016998002735 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1016998002736 histidine operon leader 1016998002737 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1016998002738 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1016998002739 putative NAD(P) binding site [chemical binding]; other site 1016998002740 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998002741 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1016998002742 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1016998002743 dimerization interface [polypeptide binding]; other site 1016998002744 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1016998002745 exonuclease I; Provisional; Region: sbcB; PRK11779 1016998002746 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1016998002747 active site 1016998002748 catalytic site [active] 1016998002749 substrate binding site [chemical binding]; other site 1016998002750 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1016998002751 integrase; Provisional; Region: PRK09692 1016998002752 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1016998002753 active site 1016998002754 Int/Topo IB signature motif; other site 1016998002755 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 1016998002756 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1016998002757 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 1016998002758 phage recombination protein Bet; Region: bet_lambda; TIGR01913 1016998002759 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 1016998002760 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 1016998002761 xanthoxin dehydrogenase; Region: PLN02253 1016998002762 transcriptional repressor DicA; Reviewed; Region: PRK09706 1016998002763 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1016998002764 non-specific DNA binding site [nucleotide binding]; other site 1016998002765 salt bridge; other site 1016998002766 sequence-specific DNA binding site [nucleotide binding]; other site 1016998002767 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 1016998002768 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 1016998002769 Replication protein P; Region: Phage_lambda_P; pfam06992 1016998002770 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 1016998002771 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 1016998002772 Protein of unknown function (DUF550); Region: DUF550; pfam04447 1016998002773 Protein of unknown function (DUF551); Region: DUF551; pfam04448 1016998002774 DinI-like family; Region: DinI; pfam06183 1016998002775 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 1016998002776 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 1016998002777 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 1016998002778 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 1016998002779 Predicted chitinase [General function prediction only]; Region: COG3179 1016998002780 catalytic residue [active] 1016998002781 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 1016998002782 YfbU domain; Region: YfbU; cl01137 1016998002783 large terminase protein; Provisional; Region: 17; PHA02533 1016998002784 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 1016998002785 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 1016998002786 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1016998002787 nudix motif; other site 1016998002788 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 1016998002789 Hs1pro-1 N-terminus; Region: Hs1pro-1_N; pfam07231 1016998002790 virion protein; Provisional; Region: V; PHA02564 1016998002791 Baseplate J-like protein; Region: Baseplate_J; cl01294 1016998002792 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 1016998002793 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1016998002794 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1016998002795 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 1016998002796 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1016998002797 thiosulfate reductase PhsA; Provisional; Region: PRK15488 1016998002798 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1016998002799 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 1016998002800 putative [Fe4-S4] binding site [ion binding]; other site 1016998002801 putative molybdopterin cofactor binding site [chemical binding]; other site 1016998002802 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1016998002803 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 1016998002804 putative molybdopterin cofactor binding site; other site 1016998002805 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 1016998002806 4Fe-4S binding domain; Region: Fer4; cl02805 1016998002807 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 1016998002808 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 1016998002809 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 1016998002810 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1016998002811 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1016998002812 DNA gyrase inhibitor; Provisional; Region: PRK10016 1016998002813 Predicted membrane protein [Function unknown]; Region: COG1289 1016998002814 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1016998002815 hypothetical protein; Provisional; Region: PRK05423 1016998002816 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 1016998002817 propionate kinase; Reviewed; Region: PRK12397 1016998002818 propionate/acetate kinase; Provisional; Region: PRK12379 1016998002819 Ethanolamine utilisation - propanediol utilisation; Region: PduV-EutP; pfam10662 1016998002820 G3 box; other site 1016998002821 Switch II region; other site 1016998002822 GTP/Mg2+ binding site [chemical binding]; other site 1016998002823 G4 box; other site 1016998002824 G5 box; other site 1016998002825 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 1016998002826 putative hexamer interface [polypeptide binding]; other site 1016998002827 putative hexagonal pore; other site 1016998002828 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 1016998002829 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 1016998002830 putative hexamer interface [polypeptide binding]; other site 1016998002831 putative hexagonal pore; other site 1016998002832 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 1016998002833 putative hexamer interface [polypeptide binding]; other site 1016998002834 putative hexagonal pore; other site 1016998002835 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 1016998002836 SLBB domain; Region: SLBB; pfam10531 1016998002837 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 1016998002838 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 1016998002839 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1016998002840 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 1016998002841 putative active site [active] 1016998002842 metal binding site [ion binding]; metal-binding site 1016998002843 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 1016998002844 putative catalytic cysteine [active] 1016998002845 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1016998002846 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 1016998002847 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1016998002848 Hexamer/Pentamer interface [polypeptide binding]; other site 1016998002849 central pore; other site 1016998002850 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 1016998002851 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 1016998002852 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1016998002853 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1016998002854 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1016998002855 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 1016998002856 putative hexamer interface [polypeptide binding]; other site 1016998002857 putative hexagonal pore; other site 1016998002858 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1016998002859 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 1016998002860 Hexamer interface [polypeptide binding]; other site 1016998002861 Putative hexagonal pore residue; other site 1016998002862 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 1016998002863 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 1016998002864 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 1016998002865 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 1016998002866 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 1016998002867 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 1016998002868 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 1016998002869 alpha-beta subunit interface [polypeptide binding]; other site 1016998002870 alpha-gamma subunit interface [polypeptide binding]; other site 1016998002871 active site 1016998002872 substrate and K+ binding site; other site 1016998002873 K+ binding site [ion binding]; other site 1016998002874 cobalamin binding site [chemical binding]; other site 1016998002875 propanediol utilization protein PduB; Provisional; Region: PRK15415 1016998002876 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 1016998002877 putative hexamer interface [polypeptide binding]; other site 1016998002878 putative hexagonal pore; other site 1016998002879 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 1016998002880 putative hexamer interface [polypeptide binding]; other site 1016998002881 putative hexagonal pore; other site 1016998002882 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1016998002883 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 1016998002884 Hexamer interface [polypeptide binding]; other site 1016998002885 Putative hexagonal pore residue; other site 1016998002886 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1016998002887 amphipathic channel; other site 1016998002888 Asn-Pro-Ala signature motifs; other site 1016998002889 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 1016998002890 Sensory domain found in PocR; Region: PocR; pfam10114 1016998002891 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1016998002892 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1016998002893 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1016998002894 cobalamin riboswitch 1016998002895 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1016998002896 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1016998002897 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1016998002898 catalytic triad [active] 1016998002899 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1016998002900 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 1016998002901 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1016998002902 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 1016998002903 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1016998002904 active site 1016998002905 putative homodimer interface [polypeptide binding]; other site 1016998002906 SAM binding site [chemical binding]; other site 1016998002907 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 1016998002908 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1016998002909 S-adenosylmethionine binding site [chemical binding]; other site 1016998002910 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1016998002911 active site 1016998002912 SAM binding site [chemical binding]; other site 1016998002913 homodimer interface [polypeptide binding]; other site 1016998002914 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 1016998002915 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 1016998002916 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 1016998002917 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1016998002918 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1016998002919 active site 1016998002920 SAM binding site [chemical binding]; other site 1016998002921 homodimer interface [polypeptide binding]; other site 1016998002922 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 1016998002923 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1016998002924 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 1016998002925 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 1016998002926 active site 1016998002927 C-terminal domain interface [polypeptide binding]; other site 1016998002928 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 1016998002929 active site 1016998002930 N-terminal domain interface [polypeptide binding]; other site 1016998002931 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1016998002932 active site 1016998002933 SAM binding site [chemical binding]; other site 1016998002934 homodimer interface [polypeptide binding]; other site 1016998002935 cobalt transport protein CbiM; Validated; Region: PRK08319 1016998002936 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1016998002937 cobalt transport protein CbiN; Provisional; Region: PRK02898 1016998002938 cobalt transport protein CbiQ; Provisional; Region: PRK15485 1016998002939 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 1016998002940 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1016998002941 Walker A/P-loop; other site 1016998002942 ATP binding site [chemical binding]; other site 1016998002943 Q-loop/lid; other site 1016998002944 ABC transporter signature motif; other site 1016998002945 Walker B; other site 1016998002946 D-loop; other site 1016998002947 H-loop/switch region; other site 1016998002948 cobyric acid synthase; Provisional; Region: PRK00784 1016998002949 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1016998002950 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1016998002951 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1016998002952 catalytic triad [active] 1016998002953 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1016998002954 homotrimer interface [polypeptide binding]; other site 1016998002955 Walker A motif; other site 1016998002956 GTP binding site [chemical binding]; other site 1016998002957 Walker B motif; other site 1016998002958 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1016998002959 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1016998002960 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1016998002961 putative dimer interface [polypeptide binding]; other site 1016998002962 active site pocket [active] 1016998002963 putative cataytic base [active] 1016998002964 L,D-transpeptidase; Provisional; Region: PRK10190 1016998002965 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1016998002966 MATE family multidrug exporter; Provisional; Region: PRK10189 1016998002967 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 1016998002968 AMP nucleosidase; Provisional; Region: PRK08292 1016998002969 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1016998002970 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1016998002971 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cl00723 1016998002972 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 1016998002973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1016998002974 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1016998002975 Sel1 repeat; Region: Sel1; pfam08238 1016998002976 Sel1-like repeats; Region: SEL1; smart00671 1016998002977 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 1016998002978 Integrase; Region: Integrase_1; pfam12835 1016998002979 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 1016998002980 putative protease; Region: PHA00666 1016998002981 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 1016998002982 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1016998002983 MukE-like family; Region: MukE; cl11471 1016998002984 cell division protein MukB; Provisional; Region: mukB; PRK04863 1016998002985 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1016998002986 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1016998002987 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1016998002988 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1016998002989 Part of AAA domain; Region: AAA_19; pfam13245 1016998002990 Family description; Region: UvrD_C_2; pfam13538 1016998002991 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1016998002992 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 1016998002993 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 1016998002994 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 1016998002995 hypothetical protein; Provisional; Region: PRK06153 1016998002996 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 1016998002997 ATP binding site [chemical binding]; other site 1016998002998 substrate interface [chemical binding]; other site 1016998002999 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 1016998003000 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1016998003001 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1016998003002 non-specific DNA binding site [nucleotide binding]; other site 1016998003003 salt bridge; other site 1016998003004 sequence-specific DNA binding site [nucleotide binding]; other site 1016998003005 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 1016998003006 Integrase; Region: Integrase_1; pfam12835 1016998003007 integrase; Provisional; Region: PRK09692 1016998003008 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1016998003009 active site 1016998003010 Int/Topo IB signature motif; other site 1016998003011 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 1016998003012 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1016998003013 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1016998003014 Catalytic site [active] 1016998003015 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1016998003016 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1016998003017 active site 1016998003018 DNA binding site [nucleotide binding] 1016998003019 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1016998003020 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1016998003021 DNA-binding site [nucleotide binding]; DNA binding site 1016998003022 RNA-binding motif; other site 1016998003023 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1016998003024 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1016998003025 trimer interface [polypeptide binding]; other site 1016998003026 eyelet of channel; other site 1016998003027 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1016998003028 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1016998003029 Zn2+ binding site [ion binding]; other site 1016998003030 Mg2+ binding site [ion binding]; other site 1016998003031 DNA cytosine methylase; Provisional; Region: PRK10458 1016998003032 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1016998003033 cofactor binding site; other site 1016998003034 DNA binding site [nucleotide binding] 1016998003035 substrate interaction site [chemical binding]; other site 1016998003036 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1016998003037 additional DNA contacts [nucleotide binding]; other site 1016998003038 mismatch recognition site; other site 1016998003039 active site 1016998003040 zinc binding site [ion binding]; other site 1016998003041 DNA intercalation site [nucleotide binding]; other site 1016998003042 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1016998003043 EamA-like transporter family; Region: EamA; pfam00892 1016998003044 EamA-like transporter family; Region: EamA; pfam00892 1016998003045 hypothetical protein; Provisional; Region: PRK10062 1016998003046 Uncharacterized small protein [Function unknown]; Region: COG5475 1016998003047 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 1016998003048 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1016998003049 metal binding site [ion binding]; metal-binding site 1016998003050 active site 1016998003051 I-site; other site 1016998003052 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 1016998003053 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1016998003054 active site 1016998003055 motif I; other site 1016998003056 motif II; other site 1016998003057 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 1016998003058 hypothetical protein; Provisional; Region: PRK10708 1016998003059 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 1016998003060 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1016998003061 DNA binding residues [nucleotide binding] 1016998003062 dimerization interface [polypeptide binding]; other site 1016998003063 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1016998003064 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1016998003065 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1016998003066 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 1016998003067 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 1016998003068 flagellar motor switch protein; Validated; Region: fliN; PRK05698 1016998003069 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1016998003070 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1016998003071 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 1016998003072 flagellar hook-length control protein; Provisional; Region: PRK10118 1016998003073 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 1016998003074 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1016998003075 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 1016998003076 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 1016998003077 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1016998003078 Walker A motif/ATP binding site; other site 1016998003079 Walker B motif; other site 1016998003080 flagellar assembly protein H; Validated; Region: fliH; PRK05687 1016998003081 Flagellar assembly protein FliH; Region: FliH; pfam02108 1016998003082 flagellar motor switch protein FliG; Region: fliG; TIGR00207 1016998003083 FliG C-terminal domain; Region: FliG_C; pfam01706 1016998003084 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1016998003085 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1016998003086 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1016998003087 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 1016998003088 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 1016998003089 CPxP motif; other site 1016998003090 putative inner membrane protein; Provisional; Region: PRK11099 1016998003091 Sulphur transport; Region: Sulf_transp; pfam04143 1016998003092 lipoprotein; Provisional; Region: PRK10397 1016998003093 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 1016998003094 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 1016998003095 active site 1016998003096 Na/Ca binding site [ion binding]; other site 1016998003097 catalytic site [active] 1016998003098 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 1016998003099 flagellar protein FliS; Validated; Region: fliS; PRK05685 1016998003100 flagellar capping protein; Reviewed; Region: fliD; PRK08032 1016998003101 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1016998003102 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1016998003103 flagellin; Validated; Region: PRK08026 1016998003104 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1016998003105 Flagellin D3 domain; Region: Flagellin_D3; pfam08884 1016998003106 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1016998003107 Helix-turn-helix domain; Region: HTH_28; pfam13518 1016998003108 Integrase core domain; Region: rve; pfam00665 1016998003109 Integrase core domain; Region: rve_3; pfam13683 1016998003110 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 1016998003111 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1016998003112 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1016998003113 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1016998003114 DNA binding residues [nucleotide binding] 1016998003115 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 1016998003116 cystine transporter subunit; Provisional; Region: PRK11260 1016998003117 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1016998003118 substrate binding pocket [chemical binding]; other site 1016998003119 membrane-bound complex binding site; other site 1016998003120 hinge residues; other site 1016998003121 D-cysteine desulfhydrase; Validated; Region: PRK03910 1016998003122 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 1016998003123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998003124 catalytic residue [active] 1016998003125 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1016998003126 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998003127 dimer interface [polypeptide binding]; other site 1016998003128 conserved gate region; other site 1016998003129 putative PBP binding loops; other site 1016998003130 ABC-ATPase subunit interface; other site 1016998003131 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 1016998003132 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1016998003133 Walker A/P-loop; other site 1016998003134 ATP binding site [chemical binding]; other site 1016998003135 Q-loop/lid; other site 1016998003136 ABC transporter signature motif; other site 1016998003137 Walker B; other site 1016998003138 D-loop; other site 1016998003139 H-loop/switch region; other site 1016998003140 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1016998003141 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 1016998003142 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1016998003143 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1016998003144 DNA binding residues [nucleotide binding] 1016998003145 dimerization interface [polypeptide binding]; other site 1016998003146 hypothetical protein; Provisional; Region: PRK10613 1016998003147 response regulator; Provisional; Region: PRK09483 1016998003148 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1016998003149 active site 1016998003150 phosphorylation site [posttranslational modification] 1016998003151 intermolecular recognition site; other site 1016998003152 dimerization interface [polypeptide binding]; other site 1016998003153 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1016998003154 DNA binding residues [nucleotide binding] 1016998003155 dimerization interface [polypeptide binding]; other site 1016998003156 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1016998003157 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1016998003158 GIY-YIG motif/motif A; other site 1016998003159 active site 1016998003160 catalytic site [active] 1016998003161 putative DNA binding site [nucleotide binding]; other site 1016998003162 metal binding site [ion binding]; metal-binding site 1016998003163 UvrB/uvrC motif; Region: UVR; pfam02151 1016998003164 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1016998003165 Helix-hairpin-helix motif; Region: HHH; pfam00633 1016998003166 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 1016998003167 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 1016998003168 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 1016998003169 NlpC/P60 family; Region: NLPC_P60; cl17555 1016998003170 glucose-6-phosphate 1-dehydrogenase; Region: PLN02640 1016998003171 hypothetical protein; Provisional; Region: PRK10396 1016998003172 yecA family protein; Region: ygfB_yecA; TIGR02292 1016998003173 SEC-C motif; Region: SEC-C; pfam02810 1016998003174 tyrosine transporter TyrP; Provisional; Region: PRK15132 1016998003175 aromatic amino acid transport protein; Region: araaP; TIGR00837 1016998003176 probable metal-binding protein; Region: matur_matur; TIGR03853 1016998003177 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1016998003178 Ferritin-like domain; Region: Ferritin; pfam00210 1016998003179 ferroxidase diiron center [ion binding]; other site 1016998003180 YecR-like lipoprotein; Region: YecR; pfam13992 1016998003181 hypothetical protein; Provisional; Region: PRK09273 1016998003182 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 1016998003183 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 1016998003184 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1016998003185 Ferritin-like domain; Region: Ferritin; pfam00210 1016998003186 ferroxidase diiron center [ion binding]; other site 1016998003187 DJ-1 family protein; Region: not_thiJ; TIGR01383 1016998003188 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1016998003189 conserved cys residue [active] 1016998003190 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 1016998003191 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1016998003192 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1016998003193 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1016998003194 active site 1016998003195 homotetramer interface [polypeptide binding]; other site 1016998003196 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1016998003197 Ligand Binding Site [chemical binding]; other site 1016998003198 transcriptional activator FlhD; Provisional; Region: PRK02909 1016998003199 transcriptional activator FlhC; Provisional; Region: PRK12722 1016998003200 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1016998003201 flagellar motor protein MotA; Validated; Region: PRK09110 1016998003202 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1016998003203 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1016998003204 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1016998003205 ligand binding site [chemical binding]; other site 1016998003206 chemotaxis protein CheA; Provisional; Region: PRK10547 1016998003207 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1016998003208 putative binding surface; other site 1016998003209 active site 1016998003210 CheY binding; Region: CheY-binding; pfam09078 1016998003211 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1016998003212 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1016998003213 ATP binding site [chemical binding]; other site 1016998003214 Mg2+ binding site [ion binding]; other site 1016998003215 G-X-G motif; other site 1016998003216 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1016998003217 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1016998003218 putative CheA interaction surface; other site 1016998003219 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 1016998003220 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1016998003221 dimer interface [polypeptide binding]; other site 1016998003222 ligand binding site [chemical binding]; other site 1016998003223 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1016998003224 dimerization interface [polypeptide binding]; other site 1016998003225 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1016998003226 dimer interface [polypeptide binding]; other site 1016998003227 putative CheW interface [polypeptide binding]; other site 1016998003228 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 1016998003229 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1016998003230 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1016998003231 S-adenosylmethionine binding site [chemical binding]; other site 1016998003232 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1016998003233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1016998003234 active site 1016998003235 phosphorylation site [posttranslational modification] 1016998003236 intermolecular recognition site; other site 1016998003237 dimerization interface [polypeptide binding]; other site 1016998003238 CheB methylesterase; Region: CheB_methylest; pfam01339 1016998003239 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1016998003240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1016998003241 active site 1016998003242 phosphorylation site [posttranslational modification] 1016998003243 intermolecular recognition site; other site 1016998003244 dimerization interface [polypeptide binding]; other site 1016998003245 chemotaxis regulator CheZ; Provisional; Region: PRK11166 1016998003246 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1016998003247 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1016998003248 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1016998003249 FHIPEP family; Region: FHIPEP; pfam00771 1016998003250 Flagellar protein FlhE; Region: FlhE; pfam06366 1016998003251 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1016998003252 penicillin-binding protein 2; Provisional; Region: PRK10795 1016998003253 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1016998003254 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1016998003255 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1016998003256 arginyl-tRNA synthetase; Region: argS; TIGR00456 1016998003257 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1016998003258 active site 1016998003259 HIGH motif; other site 1016998003260 KMSK motif region; other site 1016998003261 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1016998003262 tRNA binding surface [nucleotide binding]; other site 1016998003263 anticodon binding site; other site 1016998003264 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 1016998003265 putative metal binding site [ion binding]; other site 1016998003266 copper homeostasis protein CutC; Provisional; Region: PRK11572 1016998003267 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1016998003268 S-adenosylmethionine binding site [chemical binding]; other site 1016998003269 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1016998003270 S-adenosylmethionine binding site [chemical binding]; other site 1016998003271 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 1016998003272 hypothetical protein; Provisional; Region: PRK10302 1016998003273 Isochorismatase family; Region: Isochorismatase; pfam00857 1016998003274 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1016998003275 catalytic triad [active] 1016998003276 conserved cis-peptide bond; other site 1016998003277 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1016998003278 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1016998003279 dimer interface [polypeptide binding]; other site 1016998003280 anticodon binding site; other site 1016998003281 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1016998003282 homodimer interface [polypeptide binding]; other site 1016998003283 motif 1; other site 1016998003284 active site 1016998003285 motif 2; other site 1016998003286 GAD domain; Region: GAD; pfam02938 1016998003287 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1016998003288 active site 1016998003289 motif 3; other site 1016998003290 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 1016998003291 nudix motif; other site 1016998003292 hypothetical protein; Validated; Region: PRK00110 1016998003293 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1016998003294 active site 1016998003295 putative DNA-binding cleft [nucleotide binding]; other site 1016998003296 dimer interface [polypeptide binding]; other site 1016998003297 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 1016998003298 hypothetical protein; Provisional; Region: PRK11470 1016998003299 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1016998003300 RuvA N terminal domain; Region: RuvA_N; pfam01330 1016998003301 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1016998003302 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1016998003303 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1016998003304 Walker A motif; other site 1016998003305 ATP binding site [chemical binding]; other site 1016998003306 Walker B motif; other site 1016998003307 arginine finger; other site 1016998003308 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1016998003309 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1016998003310 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1016998003311 ABC-ATPase subunit interface; other site 1016998003312 dimer interface [polypeptide binding]; other site 1016998003313 putative PBP binding regions; other site 1016998003314 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1016998003315 Q-loop/lid; other site 1016998003316 ABC transporter signature motif; other site 1016998003317 Walker B; other site 1016998003318 D-loop; other site 1016998003319 H-loop/switch region; other site 1016998003320 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 1016998003321 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1016998003322 metal binding site [ion binding]; metal-binding site 1016998003323 putative peptidase; Provisional; Region: PRK11649 1016998003324 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 1016998003325 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1016998003326 Peptidase family M23; Region: Peptidase_M23; pfam01551 1016998003327 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1016998003328 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1016998003329 putative acyl-acceptor binding pocket; other site 1016998003330 pyruvate kinase; Provisional; Region: PRK05826 1016998003331 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1016998003332 domain interfaces; other site 1016998003333 active site 1016998003334 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1016998003335 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1016998003336 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1016998003337 putative active site [active] 1016998003338 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1016998003339 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1016998003340 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1016998003341 phosphogluconate dehydratase; Validated; Region: PRK09054 1016998003342 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1016998003343 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1016998003344 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1016998003345 active site 1016998003346 intersubunit interface [polypeptide binding]; other site 1016998003347 catalytic residue [active] 1016998003348 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1016998003349 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1016998003350 ATP-grasp domain; Region: ATP-grasp; pfam02222 1016998003351 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 1016998003352 hypothetical protein; Provisional; Region: PRK13680 1016998003353 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 1016998003354 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1016998003355 putative metal binding site [ion binding]; other site 1016998003356 protease 2; Provisional; Region: PRK10115 1016998003357 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1016998003358 exodeoxyribonuclease X; Provisional; Region: PRK07983 1016998003359 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1016998003360 active site 1016998003361 catalytic site [active] 1016998003362 substrate binding site [chemical binding]; other site 1016998003363 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1016998003364 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 1016998003365 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 1016998003366 hypothetical protein; Provisional; Region: PRK10301 1016998003367 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1016998003368 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 1016998003369 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1016998003370 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1016998003371 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 1016998003372 dimer interface [polypeptide binding]; other site 1016998003373 active site 1016998003374 Int/Topo IB signature motif; other site 1016998003375 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 1016998003376 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 1016998003377 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1016998003378 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1016998003379 substrate binding pocket [chemical binding]; other site 1016998003380 membrane-bound complex binding site; other site 1016998003381 hinge residues; other site 1016998003382 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 1016998003383 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1016998003384 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 1016998003385 dimer interface [polypeptide binding]; other site 1016998003386 active site 1016998003387 Int/Topo IB signature motif; other site 1016998003388 exonuclease VIII; Reviewed; Region: PRK09709 1016998003389 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1016998003390 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 1016998003391 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 1016998003392 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 1016998003393 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 1016998003394 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1016998003395 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1016998003396 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1016998003397 EamA-like transporter family; Region: EamA; pfam00892 1016998003398 EamA-like transporter family; Region: EamA; pfam00892 1016998003399 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1016998003400 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1016998003401 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 1016998003402 type III secretion protein SopE2; Provisional; Region: PRK15280 1016998003403 Salmonella type III secretion SopE effector N-terminus; Region: SecIII_SopE_N; pfam05364 1016998003404 SopE GEF domain; Region: SopE_GEF; pfam07487 1016998003405 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 1016998003406 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1016998003407 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 1016998003408 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 1016998003409 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 1016998003410 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1016998003411 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1016998003412 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1016998003413 mce related protein; Region: MCE; pfam02470 1016998003414 mce related protein; Region: MCE; pfam02470 1016998003415 mce related protein; Region: MCE; pfam02470 1016998003416 mce related protein; Region: MCE; pfam02470 1016998003417 mce related protein; Region: MCE; pfam02470 1016998003418 mce related protein; Region: MCE; pfam02470 1016998003419 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 1016998003420 Paraquat-inducible protein A; Region: PqiA; pfam04403 1016998003421 Paraquat-inducible protein A; Region: PqiA; pfam04403 1016998003422 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1016998003423 GAF domain; Region: GAF_2; pfam13185 1016998003424 ProP expression regulator; Provisional; Region: PRK04950 1016998003425 ProQ/FINO family; Region: ProQ; pfam04352 1016998003426 carboxy-terminal protease; Provisional; Region: PRK11186 1016998003427 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1016998003428 protein binding site [polypeptide binding]; other site 1016998003429 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1016998003430 Catalytic dyad [active] 1016998003431 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 1016998003432 heat shock protein HtpX; Provisional; Region: PRK05457 1016998003433 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998003434 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1016998003435 putative substrate translocation pore; other site 1016998003436 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998003437 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 1016998003438 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1016998003439 dimerization interface [polypeptide binding]; other site 1016998003440 putative Zn2+ binding site [ion binding]; other site 1016998003441 putative DNA binding site [nucleotide binding]; other site 1016998003442 Bacterial transcriptional regulator; Region: IclR; pfam01614 1016998003443 YobH-like protein; Region: YobH; pfam13996 1016998003444 PhoPQ regulatory protein; Provisional; Region: PRK10299 1016998003445 YebO-like protein; Region: YebO; pfam13974 1016998003446 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1016998003447 DNA-binding site [nucleotide binding]; DNA binding site 1016998003448 RNA-binding motif; other site 1016998003449 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1016998003450 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1016998003451 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1016998003452 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1016998003453 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1016998003454 S-adenosylmethionine binding site [chemical binding]; other site 1016998003455 hypothetical protein; Provisional; Region: PRK11469 1016998003456 Domain of unknown function DUF; Region: DUF204; pfam02659 1016998003457 Domain of unknown function DUF; Region: DUF204; pfam02659 1016998003458 yybp-ykoy leader 1016998003459 hypothetical protein; Provisional; Region: PRK02913 1016998003460 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 1016998003461 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1016998003462 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1016998003463 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1016998003464 active pocket/dimerization site; other site 1016998003465 active site 1016998003466 phosphorylation site [posttranslational modification] 1016998003467 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1016998003468 active site 1016998003469 phosphorylation site [posttranslational modification] 1016998003470 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1016998003471 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1016998003472 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1016998003473 Transporter associated domain; Region: CorC_HlyC; smart01091 1016998003474 phage resistance protein; Provisional; Region: PRK10551 1016998003475 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1016998003476 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1016998003477 L-serine deaminase; Provisional; Region: PRK15023 1016998003478 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1016998003479 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1016998003480 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1016998003481 putative active site [active] 1016998003482 putative CoA binding site [chemical binding]; other site 1016998003483 nudix motif; other site 1016998003484 metal binding site [ion binding]; metal-binding site 1016998003485 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 1016998003486 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1016998003487 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 1016998003488 hypothetical protein; Provisional; Region: PRK05114 1016998003489 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1016998003490 homotrimer interaction site [polypeptide binding]; other site 1016998003491 putative active site [active] 1016998003492 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1016998003493 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1016998003494 DEAD_2; Region: DEAD_2; pfam06733 1016998003495 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1016998003496 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 1016998003497 Glycoprotease family; Region: Peptidase_M22; pfam00814 1016998003498 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 1016998003499 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 1016998003500 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1016998003501 acyl-activating enzyme (AAE) consensus motif; other site 1016998003502 putative AMP binding site [chemical binding]; other site 1016998003503 putative active site [active] 1016998003504 putative CoA binding site [chemical binding]; other site 1016998003505 ribonuclease D; Provisional; Region: PRK10829 1016998003506 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1016998003507 catalytic site [active] 1016998003508 putative active site [active] 1016998003509 putative substrate binding site [chemical binding]; other site 1016998003510 HRDC domain; Region: HRDC; cl02578 1016998003511 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1016998003512 cell division inhibitor MinD; Provisional; Region: PRK10818 1016998003513 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1016998003514 Switch I; other site 1016998003515 Switch II; other site 1016998003516 septum formation inhibitor; Reviewed; Region: minC; PRK03511 1016998003517 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1016998003518 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1016998003519 YcgL domain; Region: YcgL; cl01189 1016998003520 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1016998003521 hypothetical protein; Provisional; Region: PRK10691 1016998003522 hypothetical protein; Provisional; Region: PRK05170 1016998003523 GnsA/GnsB family; Region: GnsAB; pfam08178 1016998003524 Domain of unknown function (DUF1971); Region: DUF1971; cl17717 1016998003525 disulfide bond formation protein B; Provisional; Region: PRK01749 1016998003526 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1016998003527 transmembrane helices; other site 1016998003528 fatty acid metabolism regulator; Provisional; Region: PRK04984 1016998003529 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1016998003530 DNA-binding site [nucleotide binding]; DNA binding site 1016998003531 FadR C-terminal domain; Region: FadR_C; pfam07840 1016998003532 SpoVR family protein; Provisional; Region: PRK11767 1016998003533 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1016998003534 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1016998003535 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1016998003536 alanine racemase; Reviewed; Region: dadX; PRK03646 1016998003537 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1016998003538 active site 1016998003539 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1016998003540 substrate binding site [chemical binding]; other site 1016998003541 catalytic residues [active] 1016998003542 dimer interface [polypeptide binding]; other site 1016998003543 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 1016998003544 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1016998003545 TrkA-C domain; Region: TrkA_C; pfam02080 1016998003546 Transporter associated domain; Region: CorC_HlyC; smart01091 1016998003547 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1016998003548 dimer interface [polypeptide binding]; other site 1016998003549 catalytic triad [active] 1016998003550 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 1016998003551 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1016998003552 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1016998003553 catalytic residue [active] 1016998003554 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1016998003555 Flagellar regulator YcgR; Region: YcgR; pfam07317 1016998003556 PilZ domain; Region: PilZ; pfam07238 1016998003557 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1016998003558 trehalase; Provisional; Region: treA; PRK13271 1016998003559 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 1016998003560 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1016998003561 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1016998003562 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1016998003563 NAD(P) binding site [chemical binding]; other site 1016998003564 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 1016998003565 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1016998003566 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 1016998003567 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1016998003568 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 1016998003569 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 1016998003570 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 1016998003571 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1016998003572 putative substrate-binding site; other site 1016998003573 nickel binding site [ion binding]; other site 1016998003574 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 1016998003575 hydrogenase 1 large subunit; Provisional; Region: PRK10170 1016998003576 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1016998003577 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 1016998003578 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1016998003579 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1016998003580 Protein of unknown function (DUF2743); Region: DUF2743; pfam10899 1016998003581 Protein of unknown function (DUF4427); Region: DUF4427; pfam14468 1016998003582 GTP-binding protein YchF; Reviewed; Region: PRK09601 1016998003583 YchF GTPase; Region: YchF; cd01900 1016998003584 G1 box; other site 1016998003585 GTP/Mg2+ binding site [chemical binding]; other site 1016998003586 Switch I region; other site 1016998003587 G2 box; other site 1016998003588 Switch II region; other site 1016998003589 G3 box; other site 1016998003590 G4 box; other site 1016998003591 G5 box; other site 1016998003592 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1016998003593 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1016998003594 putative active site [active] 1016998003595 catalytic residue [active] 1016998003596 hypothetical protein; Provisional; Region: PRK10692 1016998003597 putative transporter; Provisional; Region: PRK11660 1016998003598 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1016998003599 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1016998003600 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1016998003601 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1016998003602 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1016998003603 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1016998003604 active site 1016998003605 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1016998003606 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1016998003607 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1016998003608 Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017 1016998003609 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1016998003610 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1016998003611 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1016998003612 tRNA; other site 1016998003613 putative tRNA binding site [nucleotide binding]; other site 1016998003614 putative NADP binding site [chemical binding]; other site 1016998003615 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1016998003616 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1016998003617 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1016998003618 RF-1 domain; Region: RF-1; pfam00472 1016998003619 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1016998003620 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1016998003621 hypothetical protein; Provisional; Region: PRK10278 1016998003622 hypothetical protein; Provisional; Region: PRK10941 1016998003623 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1016998003624 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 1016998003625 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1016998003626 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 1016998003627 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1016998003628 cation transport regulator; Reviewed; Region: chaB; PRK09582 1016998003629 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 1016998003630 putative invasin; Provisional; Region: PRK10177 1016998003631 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1016998003632 transcriptional regulator NarL; Provisional; Region: PRK10651 1016998003633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1016998003634 active site 1016998003635 phosphorylation site [posttranslational modification] 1016998003636 intermolecular recognition site; other site 1016998003637 dimerization interface [polypeptide binding]; other site 1016998003638 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1016998003639 DNA binding residues [nucleotide binding] 1016998003640 dimerization interface [polypeptide binding]; other site 1016998003641 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 1016998003642 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1016998003643 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1016998003644 dimerization interface [polypeptide binding]; other site 1016998003645 Histidine kinase; Region: HisKA_3; pfam07730 1016998003646 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1016998003647 ATP binding site [chemical binding]; other site 1016998003648 Mg2+ binding site [ion binding]; other site 1016998003649 G-X-G motif; other site 1016998003650 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1016998003651 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 1016998003652 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1016998003653 [4Fe-4S] binding site [ion binding]; other site 1016998003654 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1016998003655 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1016998003656 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1016998003657 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1016998003658 molybdopterin cofactor binding site; other site 1016998003659 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1016998003660 4Fe-4S binding domain; Region: Fer4; cl02805 1016998003661 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1016998003662 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1016998003663 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1016998003664 Sel1-like repeats; Region: SEL1; smart00671 1016998003665 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1016998003666 Sel1-like repeats; Region: SEL1; smart00671 1016998003667 Sel1-like repeats; Region: SEL1; smart00671 1016998003668 Sel1-like repeats; Region: SEL1; smart00671 1016998003669 Sel1-like repeats; Region: SEL1; smart00671 1016998003670 Sel1-like repeats; Region: SEL1; smart00671 1016998003671 Sel1-like repeats; Region: SEL1; smart00671 1016998003672 Sel1-like repeats; Region: SEL1; smart00671 1016998003673 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1016998003674 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1016998003675 putative active site [active] 1016998003676 putative substrate binding site [chemical binding]; other site 1016998003677 putative cosubstrate binding site; other site 1016998003678 catalytic site [active] 1016998003679 hypothetical protein; Provisional; Region: PRK01617 1016998003680 hypothetical protein; Provisional; Region: PRK10279 1016998003681 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1016998003682 active site 1016998003683 nucleophile elbow; other site 1016998003684 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1016998003685 active site 1016998003686 response regulator of RpoS; Provisional; Region: PRK10693 1016998003687 phosphorylation site [posttranslational modification] 1016998003688 intermolecular recognition site; other site 1016998003689 dimerization interface [polypeptide binding]; other site 1016998003690 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1016998003691 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1016998003692 active site 1016998003693 tetramer interface; other site 1016998003694 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 1016998003695 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1016998003696 thymidine kinase; Provisional; Region: PRK04296 1016998003697 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1016998003698 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1016998003699 putative catalytic cysteine [active] 1016998003700 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1016998003701 putative active site [active] 1016998003702 metal binding site [ion binding]; metal-binding site 1016998003703 hypothetical protein; Provisional; Region: PRK11111 1016998003704 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1016998003705 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1016998003706 peptide binding site [polypeptide binding]; other site 1016998003707 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1016998003708 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998003709 dimer interface [polypeptide binding]; other site 1016998003710 conserved gate region; other site 1016998003711 putative PBP binding loops; other site 1016998003712 ABC-ATPase subunit interface; other site 1016998003713 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1016998003714 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1016998003715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998003716 dimer interface [polypeptide binding]; other site 1016998003717 conserved gate region; other site 1016998003718 ABC-ATPase subunit interface; other site 1016998003719 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 1016998003720 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1016998003721 Walker A/P-loop; other site 1016998003722 ATP binding site [chemical binding]; other site 1016998003723 Q-loop/lid; other site 1016998003724 ABC transporter signature motif; other site 1016998003725 Walker B; other site 1016998003726 D-loop; other site 1016998003727 H-loop/switch region; other site 1016998003728 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1016998003729 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1016998003730 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1016998003731 Walker A/P-loop; other site 1016998003732 ATP binding site [chemical binding]; other site 1016998003733 Q-loop/lid; other site 1016998003734 ABC transporter signature motif; other site 1016998003735 Walker B; other site 1016998003736 D-loop; other site 1016998003737 H-loop/switch region; other site 1016998003738 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1016998003739 Ion transport protein; Region: Ion_trans; pfam00520 1016998003740 Ion channel; Region: Ion_trans_2; pfam07885 1016998003741 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1016998003742 Double zinc ribbon; Region: DZR; pfam12773 1016998003743 dsDNA-mimic protein; Reviewed; Region: PRK05094 1016998003744 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1016998003745 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1016998003746 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 1016998003747 putative active site [active] 1016998003748 catalytic site [active] 1016998003749 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 1016998003750 putative active site [active] 1016998003751 catalytic site [active] 1016998003752 YciI-like protein; Reviewed; Region: PRK11370 1016998003753 transport protein TonB; Provisional; Region: PRK10819 1016998003754 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1016998003755 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1016998003756 intracellular septation protein A; Reviewed; Region: PRK00259 1016998003757 hypothetical protein; Provisional; Region: PRK02868 1016998003758 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 1016998003759 outer membrane protein W; Provisional; Region: PRK10959 1016998003760 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1016998003761 dimanganese center [ion binding]; other site 1016998003762 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1016998003763 dinuclear metal binding motif [ion binding]; other site 1016998003764 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 1016998003765 dimerization interface [polypeptide binding]; other site 1016998003766 metal binding site [ion binding]; metal-binding site 1016998003767 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1016998003768 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1016998003769 substrate binding site [chemical binding]; other site 1016998003770 active site 1016998003771 catalytic residues [active] 1016998003772 heterodimer interface [polypeptide binding]; other site 1016998003773 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1016998003774 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1016998003775 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998003776 catalytic residue [active] 1016998003777 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 1016998003778 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1016998003779 active site 1016998003780 ribulose/triose binding site [chemical binding]; other site 1016998003781 phosphate binding site [ion binding]; other site 1016998003782 substrate (anthranilate) binding pocket [chemical binding]; other site 1016998003783 product (indole) binding pocket [chemical binding]; other site 1016998003784 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1016998003785 active site 1016998003786 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 1016998003787 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1016998003788 glutamine binding [chemical binding]; other site 1016998003789 catalytic triad [active] 1016998003790 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1016998003791 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1016998003792 anthranilate synthase component I; Provisional; Region: PRK13564 1016998003793 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1016998003794 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1016998003795 tryptophan operon leader 1016998003796 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1016998003797 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1016998003798 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1016998003799 hypothetical protein; Provisional; Region: PRK11630 1016998003800 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 1016998003801 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1016998003802 RNA binding surface [nucleotide binding]; other site 1016998003803 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1016998003804 probable active site [active] 1016998003805 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1016998003806 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 1016998003807 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1016998003808 homodimer interface [polypeptide binding]; other site 1016998003809 Walker A motif; other site 1016998003810 ATP binding site [chemical binding]; other site 1016998003811 hydroxycobalamin binding site [chemical binding]; other site 1016998003812 Walker B motif; other site 1016998003813 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 1016998003814 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 1016998003815 NADP binding site [chemical binding]; other site 1016998003816 homodimer interface [polypeptide binding]; other site 1016998003817 active site 1016998003818 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 1016998003819 putative inner membrane peptidase; Provisional; Region: PRK11778 1016998003820 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1016998003821 tandem repeat interface [polypeptide binding]; other site 1016998003822 oligomer interface [polypeptide binding]; other site 1016998003823 active site residues [active] 1016998003824 hypothetical protein; Provisional; Region: PRK11037 1016998003825 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1016998003826 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1016998003827 active site 1016998003828 interdomain interaction site; other site 1016998003829 putative metal-binding site [ion binding]; other site 1016998003830 nucleotide binding site [chemical binding]; other site 1016998003831 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1016998003832 domain I; other site 1016998003833 DNA binding groove [nucleotide binding] 1016998003834 phosphate binding site [ion binding]; other site 1016998003835 domain II; other site 1016998003836 domain III; other site 1016998003837 nucleotide binding site [chemical binding]; other site 1016998003838 catalytic site [active] 1016998003839 domain IV; other site 1016998003840 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1016998003841 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1016998003842 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1016998003843 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1016998003844 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 1016998003845 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 1016998003846 substrate binding site [chemical binding]; other site 1016998003847 putative dimerization interface [polypeptide binding]; other site 1016998003848 aconitate hydratase; Validated; Region: PRK09277 1016998003849 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1016998003850 substrate binding site [chemical binding]; other site 1016998003851 ligand binding site [chemical binding]; other site 1016998003852 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1016998003853 substrate binding site [chemical binding]; other site 1016998003854 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1016998003855 dimerization interface [polypeptide binding]; other site 1016998003856 active site 1016998003857 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1016998003858 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1016998003859 active site 1016998003860 Predicted membrane protein [Function unknown]; Region: COG3771 1016998003861 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 1016998003862 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1016998003863 binding surface 1016998003864 TPR motif; other site 1016998003865 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1016998003866 active site 1016998003867 dimer interface [polypeptide binding]; other site 1016998003868 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1016998003869 putative rRNA binding site [nucleotide binding]; other site 1016998003870 lipoprotein; Provisional; Region: PRK10540 1016998003871 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1016998003872 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1016998003873 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1016998003874 hypothetical protein; Provisional; Region: PRK13658 1016998003875 RNase II stability modulator; Provisional; Region: PRK10060 1016998003876 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1016998003877 putative active site [active] 1016998003878 heme pocket [chemical binding]; other site 1016998003879 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1016998003880 metal binding site [ion binding]; metal-binding site 1016998003881 active site 1016998003882 I-site; other site 1016998003883 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1016998003884 exoribonuclease II; Provisional; Region: PRK05054 1016998003885 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1016998003886 RNB domain; Region: RNB; pfam00773 1016998003887 S1 RNA binding domain; Region: S1; pfam00575 1016998003888 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 1016998003889 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1016998003890 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 1016998003891 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1016998003892 NAD binding site [chemical binding]; other site 1016998003893 homotetramer interface [polypeptide binding]; other site 1016998003894 homodimer interface [polypeptide binding]; other site 1016998003895 substrate binding site [chemical binding]; other site 1016998003896 active site 1016998003897 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1016998003898 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 1016998003899 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1016998003900 Walker A/P-loop; other site 1016998003901 ATP binding site [chemical binding]; other site 1016998003902 Q-loop/lid; other site 1016998003903 ABC transporter signature motif; other site 1016998003904 Walker B; other site 1016998003905 D-loop; other site 1016998003906 H-loop/switch region; other site 1016998003907 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 1016998003908 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1016998003909 Walker A/P-loop; other site 1016998003910 ATP binding site [chemical binding]; other site 1016998003911 Q-loop/lid; other site 1016998003912 ABC transporter signature motif; other site 1016998003913 Walker B; other site 1016998003914 D-loop; other site 1016998003915 H-loop/switch region; other site 1016998003916 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1016998003917 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 1016998003918 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1016998003919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998003920 dimer interface [polypeptide binding]; other site 1016998003921 conserved gate region; other site 1016998003922 putative PBP binding loops; other site 1016998003923 ABC-ATPase subunit interface; other site 1016998003924 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 1016998003925 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998003926 dimer interface [polypeptide binding]; other site 1016998003927 conserved gate region; other site 1016998003928 putative PBP binding loops; other site 1016998003929 ABC-ATPase subunit interface; other site 1016998003930 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1016998003931 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1016998003932 peptide binding site [polypeptide binding]; other site 1016998003933 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 1016998003934 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1016998003935 Walker A motif; other site 1016998003936 ATP binding site [chemical binding]; other site 1016998003937 Walker B motif; other site 1016998003938 arginine finger; other site 1016998003939 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1016998003940 phage shock protein PspA; Provisional; Region: PRK10698 1016998003941 phage shock protein B; Provisional; Region: pspB; PRK09458 1016998003942 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 1016998003943 phage shock protein C; Region: phageshock_pspC; TIGR02978 1016998003944 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 1016998003945 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1016998003946 active site residue [active] 1016998003947 Predicted ATPase [General function prediction only]; Region: COG3106 1016998003948 hypothetical protein; Provisional; Region: PRK05415 1016998003949 TIGR01620 family protein; Region: hyp_HI0043 1016998003950 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 1016998003951 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 1016998003952 putative aromatic amino acid binding site; other site 1016998003953 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1016998003954 Walker A motif; other site 1016998003955 ATP binding site [chemical binding]; other site 1016998003956 Walker B motif; other site 1016998003957 arginine finger; other site 1016998003958 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1016998003959 dimer interface [polypeptide binding]; other site 1016998003960 catalytic triad [active] 1016998003961 peroxidatic and resolving cysteines [active] 1016998003962 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 1016998003963 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1016998003964 active site 1016998003965 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1016998003966 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 1016998003967 putative active site [active] 1016998003968 Zn binding site [ion binding]; other site 1016998003969 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1016998003970 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1016998003971 peptide binding site [polypeptide binding]; other site 1016998003972 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 1016998003973 NmrA-like family; Region: NmrA; pfam05368 1016998003974 NAD(P) binding site [chemical binding]; other site 1016998003975 active site lysine 1016998003976 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1016998003977 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998003978 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1016998003979 putative effector binding pocket; other site 1016998003980 putative dimerization interface [polypeptide binding]; other site 1016998003981 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1016998003982 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1016998003983 active site 1016998003984 catalytic tetrad [active] 1016998003985 oxidoreductase; Provisional; Region: PRK12742 1016998003986 classical (c) SDRs; Region: SDR_c; cd05233 1016998003987 NAD(P) binding site [chemical binding]; other site 1016998003988 active site 1016998003989 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1016998003990 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1016998003991 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1016998003992 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 1016998003993 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1016998003994 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1016998003995 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1016998003996 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: Tpx; COG2077 1016998003997 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1016998003998 B3/4 domain; Region: B3_4; pfam03483 1016998003999 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1016998004000 Cupin domain; Region: Cupin_2; pfam07883 1016998004001 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1016998004002 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1016998004003 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 1016998004004 universal stress protein UspE; Provisional; Region: PRK11175 1016998004005 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1016998004006 Ligand Binding Site [chemical binding]; other site 1016998004007 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1016998004008 Ligand Binding Site [chemical binding]; other site 1016998004009 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1016998004010 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1016998004011 ligand binding site [chemical binding]; other site 1016998004012 flexible hinge region; other site 1016998004013 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1016998004014 putative switch regulator; other site 1016998004015 non-specific DNA interactions [nucleotide binding]; other site 1016998004016 DNA binding site [nucleotide binding] 1016998004017 sequence specific DNA binding site [nucleotide binding]; other site 1016998004018 putative cAMP binding site [chemical binding]; other site 1016998004019 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 1016998004020 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1016998004021 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1016998004022 DNA binding site [nucleotide binding] 1016998004023 active site 1016998004024 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1016998004025 Smr domain; Region: Smr; pfam01713 1016998004026 HAMP domain; Region: HAMP; pfam00672 1016998004027 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1016998004028 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1016998004029 dimer interface [polypeptide binding]; other site 1016998004030 putative CheW interface [polypeptide binding]; other site 1016998004031 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1016998004032 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 1016998004033 Cl binding site [ion binding]; other site 1016998004034 oligomer interface [polypeptide binding]; other site 1016998004035 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1016998004036 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1016998004037 ATP binding site [chemical binding]; other site 1016998004038 Mg++ binding site [ion binding]; other site 1016998004039 motif III; other site 1016998004040 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1016998004041 nucleotide binding region [chemical binding]; other site 1016998004042 ATP-binding site [chemical binding]; other site 1016998004043 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 1016998004044 putative RNA binding site [nucleotide binding]; other site 1016998004045 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1016998004046 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1016998004047 Ligand Binding Site [chemical binding]; other site 1016998004048 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1016998004049 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1016998004050 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1016998004051 Ligand Binding Site [chemical binding]; other site 1016998004052 Helix-turn-helix domain; Region: HTH_28; pfam13518 1016998004053 Integrase core domain; Region: rve; pfam00665 1016998004054 Integrase core domain; Region: rve_3; pfam13683 1016998004055 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1016998004056 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1016998004057 dimer interface [polypeptide binding]; other site 1016998004058 PYR/PP interface [polypeptide binding]; other site 1016998004059 TPP binding site [chemical binding]; other site 1016998004060 substrate binding site [chemical binding]; other site 1016998004061 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1016998004062 Domain of unknown function; Region: EKR; smart00890 1016998004063 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1016998004064 4Fe-4S binding domain; Region: Fer4; pfam00037 1016998004065 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1016998004066 TPP-binding site [chemical binding]; other site 1016998004067 dimer interface [polypeptide binding]; other site 1016998004068 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 1016998004069 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1016998004070 heat-inducible protein; Provisional; Region: PRK10449 1016998004071 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 1016998004072 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1016998004073 putative ligand binding site [chemical binding]; other site 1016998004074 putative NAD binding site [chemical binding]; other site 1016998004075 catalytic site [active] 1016998004076 hypothetical protein; Provisional; Region: PRK10695 1016998004077 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 1016998004078 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 1016998004079 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1016998004080 azoreductase; Reviewed; Region: PRK00170 1016998004081 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1016998004082 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1016998004083 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1016998004084 ATP binding site [chemical binding]; other site 1016998004085 putative Mg++ binding site [ion binding]; other site 1016998004086 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1016998004087 nucleotide binding region [chemical binding]; other site 1016998004088 ATP-binding site [chemical binding]; other site 1016998004089 Helicase associated domain (HA2); Region: HA2; pfam04408 1016998004090 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1016998004091 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1016998004092 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1016998004093 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1016998004094 putative active site [active] 1016998004095 cytochrome b561; Provisional; Region: PRK11513 1016998004096 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1016998004097 S-adenosylmethionine binding site [chemical binding]; other site 1016998004098 Predicted membrane protein [Function unknown]; Region: COG5305 1016998004099 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1016998004100 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998004101 dimer interface [polypeptide binding]; other site 1016998004102 conserved gate region; other site 1016998004103 putative PBP binding loops; other site 1016998004104 ABC-ATPase subunit interface; other site 1016998004105 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1016998004106 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1016998004107 Walker A/P-loop; other site 1016998004108 ATP binding site [chemical binding]; other site 1016998004109 Q-loop/lid; other site 1016998004110 ABC transporter signature motif; other site 1016998004111 Walker B; other site 1016998004112 D-loop; other site 1016998004113 H-loop/switch region; other site 1016998004114 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1016998004115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998004116 dimer interface [polypeptide binding]; other site 1016998004117 conserved gate region; other site 1016998004118 putative PBP binding loops; other site 1016998004119 ABC-ATPase subunit interface; other site 1016998004120 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1016998004121 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1016998004122 substrate binding pocket [chemical binding]; other site 1016998004123 membrane-bound complex binding site; other site 1016998004124 hinge residues; other site 1016998004125 Predicted membrane protein [Function unknown]; Region: COG3326 1016998004126 Sif protein; Region: Sif; cl11505 1016998004127 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 1016998004128 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 1016998004129 active site 1016998004130 catalytic triad [active] 1016998004131 oxyanion hole [active] 1016998004132 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1016998004133 putative metal binding site [ion binding]; other site 1016998004134 putative homodimer interface [polypeptide binding]; other site 1016998004135 putative homotetramer interface [polypeptide binding]; other site 1016998004136 putative homodimer-homodimer interface [polypeptide binding]; other site 1016998004137 putative allosteric switch controlling residues; other site 1016998004138 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1016998004139 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1016998004140 substrate binding site [chemical binding]; other site 1016998004141 catalytic Zn binding site [ion binding]; other site 1016998004142 NAD binding site [chemical binding]; other site 1016998004143 structural Zn binding site [ion binding]; other site 1016998004144 dimer interface [polypeptide binding]; other site 1016998004145 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1016998004146 dimer interface [polypeptide binding]; other site 1016998004147 ligand binding site [chemical binding]; other site 1016998004148 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1016998004149 HAMP domain; Region: HAMP; pfam00672 1016998004150 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1016998004151 dimer interface [polypeptide binding]; other site 1016998004152 putative CheW interface [polypeptide binding]; other site 1016998004153 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1016998004154 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998004155 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1016998004156 dimerization interface [polypeptide binding]; other site 1016998004157 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1016998004158 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1016998004159 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1016998004160 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1016998004161 substrate binding pocket [chemical binding]; other site 1016998004162 catalytic triad [active] 1016998004163 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 1016998004164 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 1016998004165 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1016998004166 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 1016998004167 teramer interface [polypeptide binding]; other site 1016998004168 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1016998004169 active site 1016998004170 FMN binding site [chemical binding]; other site 1016998004171 catalytic residues [active] 1016998004172 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1016998004173 Coenzyme A binding pocket [chemical binding]; other site 1016998004174 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1016998004175 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1016998004176 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1016998004177 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1016998004178 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1016998004179 substrate binding site [chemical binding]; other site 1016998004180 hexamer interface [polypeptide binding]; other site 1016998004181 metal binding site [ion binding]; metal-binding site 1016998004182 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1016998004183 active site 1016998004184 phosphorylation site [posttranslational modification] 1016998004185 membrane complex biogenesis protein, BtpA family; Region: thylakoid_BtpA; TIGR00259 1016998004186 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1016998004187 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 1016998004188 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1016998004189 active site 1016998004190 P-loop; other site 1016998004191 phosphorylation site [posttranslational modification] 1016998004192 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1016998004193 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1016998004194 oligomer interface [polypeptide binding]; other site 1016998004195 active site 1016998004196 metal binding site [ion binding]; metal-binding site 1016998004197 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1016998004198 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1016998004199 Coenzyme A binding pocket [chemical binding]; other site 1016998004200 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1016998004201 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1016998004202 putative trimer interface [polypeptide binding]; other site 1016998004203 putative CoA binding site [chemical binding]; other site 1016998004204 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 1016998004205 putative trimer interface [polypeptide binding]; other site 1016998004206 putative CoA binding site [chemical binding]; other site 1016998004207 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1016998004208 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 1016998004209 gating phenylalanine in ion channel; other site 1016998004210 tellurite resistance protein TehB; Provisional; Region: PRK11207 1016998004211 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1016998004212 S-adenosylmethionine binding site [chemical binding]; other site 1016998004213 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1016998004214 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 1016998004215 benzoate transporter; Region: benE; TIGR00843 1016998004216 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1016998004217 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1016998004218 non-specific DNA binding site [nucleotide binding]; other site 1016998004219 salt bridge; other site 1016998004220 sequence-specific DNA binding site [nucleotide binding]; other site 1016998004221 Cupin domain; Region: Cupin_2; pfam07883 1016998004222 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1016998004223 Peptidase family U32; Region: Peptidase_U32; pfam01136 1016998004224 Collagenase; Region: DUF3656; pfam12392 1016998004225 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 1016998004226 secreted effector protein SifB; Provisional; Region: sifB; PRK09499 1016998004227 D-alanyl-D-alanine dipeptidase [Cell envelope biogenesis, outer membrane]; Region: DdpX; COG2173 1016998004228 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1016998004229 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1016998004230 DNA-binding site [nucleotide binding]; DNA binding site 1016998004231 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1016998004232 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998004233 homodimer interface [polypeptide binding]; other site 1016998004234 catalytic residue [active] 1016998004235 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1016998004236 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1016998004237 tetrameric interface [polypeptide binding]; other site 1016998004238 NAD binding site [chemical binding]; other site 1016998004239 catalytic residues [active] 1016998004240 substrate binding site [chemical binding]; other site 1016998004241 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 1016998004242 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458 1016998004243 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfB; COG4457 1016998004244 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 1016998004245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1016998004246 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1016998004247 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1016998004248 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1016998004249 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1016998004250 NAD(P) binding site [chemical binding]; other site 1016998004251 substrate binding site [chemical binding]; other site 1016998004252 dimer interface [polypeptide binding]; other site 1016998004253 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 1016998004254 DNA-binding site [nucleotide binding]; DNA binding site 1016998004255 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1016998004256 FCD domain; Region: FCD; pfam07729 1016998004257 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1016998004258 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1016998004259 N-terminal plug; other site 1016998004260 ligand-binding site [chemical binding]; other site 1016998004261 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1016998004262 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1016998004263 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1016998004264 L-asparagine permease; Provisional; Region: PRK15049 1016998004265 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 1016998004266 hypothetical protein; Provisional; Region: PRK10281 1016998004267 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1016998004268 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 1016998004269 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1016998004270 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1016998004271 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1016998004272 [4Fe-4S] binding site [ion binding]; other site 1016998004273 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1016998004274 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1016998004275 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1016998004276 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1016998004277 molybdopterin cofactor binding site; other site 1016998004278 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1016998004279 TetR family transcriptional regulator; Provisional; Region: PRK14996 1016998004280 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1016998004281 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1016998004282 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998004283 putative substrate translocation pore; other site 1016998004284 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1016998004285 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1016998004286 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1016998004287 trimer interface [polypeptide binding]; other site 1016998004288 eyelet of channel; other site 1016998004289 aromatic amino acid exporter; Provisional; Region: PRK11689 1016998004290 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1016998004291 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1016998004292 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 1016998004293 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1016998004294 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1016998004295 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1016998004296 NAD binding site [chemical binding]; other site 1016998004297 substrate binding site [chemical binding]; other site 1016998004298 catalytic Zn binding site [ion binding]; other site 1016998004299 tetramer interface [polypeptide binding]; other site 1016998004300 structural Zn binding site [ion binding]; other site 1016998004301 malate dehydrogenase; Provisional; Region: PRK13529 1016998004302 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1016998004303 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1016998004304 NAD(P) binding site [chemical binding]; other site 1016998004305 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 1016998004306 biofilm-dependent modulation protein; Provisional; Region: PRK11436 1016998004307 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 1016998004308 acid-resistance protein; Provisional; Region: hdeB; PRK11566 1016998004309 Protein of unknown function (DUF1264); Region: DUF1264; pfam06884 1016998004310 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1016998004311 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1016998004312 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1016998004313 catalytic site [active] 1016998004314 active site 1016998004315 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1016998004316 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 1016998004317 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1016998004318 active site 1016998004319 catalytic site [active] 1016998004320 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1016998004321 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1016998004322 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1016998004323 active site 1016998004324 catalytic site [active] 1016998004325 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1016998004326 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1016998004327 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998004328 homodimer interface [polypeptide binding]; other site 1016998004329 catalytic residue [active] 1016998004330 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1016998004331 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1016998004332 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1016998004333 DNA binding site [nucleotide binding] 1016998004334 domain linker motif; other site 1016998004335 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1016998004336 dimerization interface (closed form) [polypeptide binding]; other site 1016998004337 ligand binding site [chemical binding]; other site 1016998004338 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1016998004339 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 1016998004340 homotrimer interaction site [polypeptide binding]; other site 1016998004341 putative active site [active] 1016998004342 S-adenosylmethionine:tRNA-ribosyltransferase- isomerase (queuine synthetase) [Translation, ribosomal structure and biogenesis]; Region: QueA; COG0809 1016998004343 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1016998004344 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1016998004345 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1016998004346 putative DNA binding site [nucleotide binding]; other site 1016998004347 putative Zn2+ binding site [ion binding]; other site 1016998004348 hypothetical protein; Provisional; Region: PRK06184 1016998004349 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1016998004350 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1016998004351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998004352 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1016998004353 putative substrate translocation pore; other site 1016998004354 PhoPQ-activated pathogenicity-related protein [General function prediction only]; Region: PqaA; COG4287 1016998004355 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998004356 putative substrate translocation pore; other site 1016998004357 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1016998004358 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1016998004359 putative NAD(P) binding site [chemical binding]; other site 1016998004360 catalytic Zn binding site [ion binding]; other site 1016998004361 structural Zn binding site [ion binding]; other site 1016998004362 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1016998004363 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1016998004364 DNA-binding site [nucleotide binding]; DNA binding site 1016998004365 FCD domain; Region: FCD; pfam07729 1016998004366 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1016998004367 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1016998004368 active site 1016998004369 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 1016998004370 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1016998004371 hydrogenase 1 large subunit; Provisional; Region: PRK10170 1016998004372 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1016998004373 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1016998004374 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 1016998004375 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1016998004376 putative substrate-binding site; other site 1016998004377 nickel binding site [ion binding]; other site 1016998004378 HupF/HypC family; Region: HupF_HypC; cl00394 1016998004379 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 1016998004380 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 1016998004381 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 1016998004382 Rubredoxin [Energy production and conversion]; Region: COG1773 1016998004383 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1016998004384 iron binding site [ion binding]; other site 1016998004385 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 1016998004386 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 1016998004387 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 1016998004388 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1016998004389 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1016998004390 trimer interface [polypeptide binding]; other site 1016998004391 eyelet of channel; other site 1016998004392 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1016998004393 Predicted membrane protein [Function unknown]; Region: COG3781 1016998004394 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 1016998004395 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1016998004396 glutaminase; Provisional; Region: PRK00971 1016998004397 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 1016998004398 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1016998004399 NAD(P) binding site [chemical binding]; other site 1016998004400 catalytic residues [active] 1016998004401 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1016998004402 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998004403 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1016998004404 putative dimerization interface [polypeptide binding]; other site 1016998004405 putative arabinose transporter; Provisional; Region: PRK03545 1016998004406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998004407 putative substrate translocation pore; other site 1016998004408 inner membrane protein; Provisional; Region: PRK10995 1016998004409 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 1016998004410 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1016998004411 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 1016998004412 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1016998004413 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1016998004414 MarB protein; Region: MarB; pfam13999 1016998004415 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1016998004416 EamA-like transporter family; Region: EamA; pfam00892 1016998004417 putative transporter; Provisional; Region: PRK10054 1016998004418 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998004419 putative substrate translocation pore; other site 1016998004420 hypothetical protein; Provisional; Region: PRK10053 1016998004421 hypothetical protein; Validated; Region: PRK03657 1016998004422 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 1016998004423 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1016998004424 active site 1016998004425 Zn binding site [ion binding]; other site 1016998004426 malonic semialdehyde reductase; Provisional; Region: PRK10538 1016998004427 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1016998004428 putative NAD(P) binding site [chemical binding]; other site 1016998004429 homodimer interface [polypeptide binding]; other site 1016998004430 homotetramer interface [polypeptide binding]; other site 1016998004431 active site 1016998004432 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1016998004433 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1016998004434 DNA-binding site [nucleotide binding]; DNA binding site 1016998004435 FCD domain; Region: FCD; pfam07729 1016998004436 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 1016998004437 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1016998004438 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1016998004439 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1016998004440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998004441 metabolite-proton symporter; Region: 2A0106; TIGR00883 1016998004442 putative substrate translocation pore; other site 1016998004443 putative oxidoreductase; Provisional; Region: PRK10083 1016998004444 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1016998004445 putative NAD(P) binding site [chemical binding]; other site 1016998004446 catalytic Zn binding site [ion binding]; other site 1016998004447 structural Zn binding site [ion binding]; other site 1016998004448 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 1016998004449 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 1016998004450 putative active site pocket [active] 1016998004451 putative metal binding site [ion binding]; other site 1016998004452 hypothetical protein; Provisional; Region: PRK02237 1016998004453 hypothetical protein; Provisional; Region: PRK13659 1016998004454 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 1016998004455 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1016998004456 Coenzyme A binding pocket [chemical binding]; other site 1016998004457 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1016998004458 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 1016998004459 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 1016998004460 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1016998004461 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1016998004462 putative [Fe4-S4] binding site [ion binding]; other site 1016998004463 putative molybdopterin cofactor binding site [chemical binding]; other site 1016998004464 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1016998004465 putative molybdopterin cofactor binding site; other site 1016998004466 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1016998004467 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1016998004468 putative [Fe4-S4] binding site [ion binding]; other site 1016998004469 putative molybdopterin cofactor binding site [chemical binding]; other site 1016998004470 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1016998004471 putative molybdopterin cofactor binding site; other site 1016998004472 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1016998004473 4Fe-4S binding domain; Region: Fer4; pfam00037 1016998004474 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 1016998004475 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 1016998004476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998004477 dimer interface [polypeptide binding]; other site 1016998004478 conserved gate region; other site 1016998004479 putative PBP binding loops; other site 1016998004480 ABC-ATPase subunit interface; other site 1016998004481 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1016998004482 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998004483 dimer interface [polypeptide binding]; other site 1016998004484 conserved gate region; other site 1016998004485 ABC-ATPase subunit interface; other site 1016998004486 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1016998004487 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1016998004488 Walker A/P-loop; other site 1016998004489 ATP binding site [chemical binding]; other site 1016998004490 Q-loop/lid; other site 1016998004491 ABC transporter signature motif; other site 1016998004492 Walker B; other site 1016998004493 D-loop; other site 1016998004494 H-loop/switch region; other site 1016998004495 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 1016998004496 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1016998004497 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1016998004498 Cl- selectivity filter; other site 1016998004499 Cl- binding residues [ion binding]; other site 1016998004500 pore gating glutamate residue; other site 1016998004501 dimer interface [polypeptide binding]; other site 1016998004502 putative dithiobiotin synthetase; Provisional; Region: PRK12374 1016998004503 AAA domain; Region: AAA_26; pfam13500 1016998004504 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1016998004505 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1016998004506 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1016998004507 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1016998004508 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998004509 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1016998004510 dimerization interface [polypeptide binding]; other site 1016998004511 substrate binding pocket [chemical binding]; other site 1016998004512 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1016998004513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998004514 putative substrate translocation pore; other site 1016998004515 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1016998004516 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 1016998004517 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 1016998004518 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 1016998004519 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1016998004520 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 1016998004521 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1016998004522 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 1016998004523 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1016998004524 ligand binding site [chemical binding]; other site 1016998004525 homodimer interface [polypeptide binding]; other site 1016998004526 NAD(P) binding site [chemical binding]; other site 1016998004527 trimer interface B [polypeptide binding]; other site 1016998004528 trimer interface A [polypeptide binding]; other site 1016998004529 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1016998004530 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1016998004531 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1016998004532 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1016998004533 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1016998004534 Spore germination protein; Region: Spore_permease; cl17796 1016998004535 GlpM protein; Region: GlpM; pfam06942 1016998004536 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 1016998004537 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1016998004538 active site 1016998004539 phosphorylation site [posttranslational modification] 1016998004540 intermolecular recognition site; other site 1016998004541 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1016998004542 DNA binding site [nucleotide binding] 1016998004543 Domain of unknown function (DUF1744); Region: DUF1744; pfam08490 1016998004544 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1016998004545 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1016998004546 trimer interface [polypeptide binding]; other site 1016998004547 eyelet of channel; other site 1016998004548 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1016998004549 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1016998004550 active site 1016998004551 sensor protein RstB; Provisional; Region: PRK10604 1016998004552 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1016998004553 dimerization interface [polypeptide binding]; other site 1016998004554 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1016998004555 dimer interface [polypeptide binding]; other site 1016998004556 phosphorylation site [posttranslational modification] 1016998004557 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1016998004558 ATP binding site [chemical binding]; other site 1016998004559 Mg2+ binding site [ion binding]; other site 1016998004560 G-X-G motif; other site 1016998004561 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 1016998004562 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1016998004563 Class II fumarases; Region: Fumarase_classII; cd01362 1016998004564 active site 1016998004565 tetramer interface [polypeptide binding]; other site 1016998004566 fumarate hydratase; Provisional; Region: PRK15389 1016998004567 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 1016998004568 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1016998004569 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1016998004570 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1016998004571 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1016998004572 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 1016998004573 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 1016998004574 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1016998004575 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1016998004576 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1016998004577 adenosine deaminase; Provisional; Region: PRK09358 1016998004578 active site 1016998004579 putative oxidoreductase; Provisional; Region: PRK11579 1016998004580 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1016998004581 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1016998004582 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 1016998004583 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 1016998004584 electron transport complex protein RsxA; Provisional; Region: PRK05151 1016998004585 electron transport complex protein RnfB; Provisional; Region: PRK05113 1016998004586 Putative Fe-S cluster; Region: FeS; cl17515 1016998004587 4Fe-4S binding domain; Region: Fer4; pfam00037 1016998004588 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 1016998004589 SLBB domain; Region: SLBB; pfam10531 1016998004590 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1016998004591 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 1016998004592 electron transport complex protein RnfG; Validated; Region: PRK01908 1016998004593 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1016998004594 endonuclease III; Provisional; Region: PRK10702 1016998004595 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1016998004596 minor groove reading motif; other site 1016998004597 helix-hairpin-helix signature motif; other site 1016998004598 substrate binding pocket [chemical binding]; other site 1016998004599 active site 1016998004600 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1016998004601 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1016998004602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998004603 putative substrate translocation pore; other site 1016998004604 POT family; Region: PTR2; pfam00854 1016998004605 glutathionine S-transferase; Provisional; Region: PRK10542 1016998004606 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1016998004607 C-terminal domain interface [polypeptide binding]; other site 1016998004608 GSH binding site (G-site) [chemical binding]; other site 1016998004609 dimer interface [polypeptide binding]; other site 1016998004610 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1016998004611 dimer interface [polypeptide binding]; other site 1016998004612 N-terminal domain interface [polypeptide binding]; other site 1016998004613 substrate binding pocket (H-site) [chemical binding]; other site 1016998004614 pyridoxamine kinase; Validated; Region: PRK05756 1016998004615 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1016998004616 dimer interface [polypeptide binding]; other site 1016998004617 pyridoxal binding site [chemical binding]; other site 1016998004618 ATP binding site [chemical binding]; other site 1016998004619 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1016998004620 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1016998004621 active site 1016998004622 HIGH motif; other site 1016998004623 dimer interface [polypeptide binding]; other site 1016998004624 KMSKS motif; other site 1016998004625 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1016998004626 RNA binding surface [nucleotide binding]; other site 1016998004627 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1016998004628 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1016998004629 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1016998004630 lysozyme inhibitor; Provisional; Region: PRK11372 1016998004631 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1016998004632 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1016998004633 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 1016998004634 transcriptional regulator SlyA; Provisional; Region: PRK03573 1016998004635 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1016998004636 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 1016998004637 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1016998004638 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1016998004639 HlyD family secretion protein; Region: HlyD_3; pfam13437 1016998004640 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1016998004641 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1016998004642 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1016998004643 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1016998004644 E-class dimer interface [polypeptide binding]; other site 1016998004645 P-class dimer interface [polypeptide binding]; other site 1016998004646 active site 1016998004647 Cu2+ binding site [ion binding]; other site 1016998004648 Zn2+ binding site [ion binding]; other site 1016998004649 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1016998004650 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1016998004651 active site 1016998004652 catalytic tetrad [active] 1016998004653 Predicted Fe-S protein [General function prediction only]; Region: COG3313 1016998004654 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1016998004655 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1016998004656 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1016998004657 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1016998004658 dimer interface [polypeptide binding]; other site 1016998004659 active site 1016998004660 metal binding site [ion binding]; metal-binding site 1016998004661 glutathione binding site [chemical binding]; other site 1016998004662 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1016998004663 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 1016998004664 dimer interface [polypeptide binding]; other site 1016998004665 catalytic site [active] 1016998004666 putative active site [active] 1016998004667 putative substrate binding site [chemical binding]; other site 1016998004668 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1016998004669 putative GSH binding site [chemical binding]; other site 1016998004670 catalytic residues [active] 1016998004671 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1016998004672 NlpC/P60 family; Region: NLPC_P60; pfam00877 1016998004673 superoxide dismutase; Provisional; Region: PRK10543 1016998004674 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1016998004675 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1016998004676 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 1016998004677 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1016998004678 DNA binding site [nucleotide binding] 1016998004679 domain linker motif; other site 1016998004680 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1016998004681 dimerization interface [polypeptide binding]; other site 1016998004682 ligand binding site [chemical binding]; other site 1016998004683 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1016998004684 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998004685 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1016998004686 dimerization interface [polypeptide binding]; other site 1016998004687 putative transporter; Provisional; Region: PRK11043 1016998004688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998004689 putative substrate translocation pore; other site 1016998004690 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 1016998004691 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1016998004692 S-adenosylmethionine binding site [chemical binding]; other site 1016998004693 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 1016998004694 Lumazine binding domain; Region: Lum_binding; pfam00677 1016998004695 Lumazine binding domain; Region: Lum_binding; pfam00677 1016998004696 multidrug efflux protein; Reviewed; Region: PRK01766 1016998004697 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1016998004698 cation binding site [ion binding]; other site 1016998004699 secretion system apparatus protein SsaU; Reviewed; Region: PRK12721 1016998004700 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1016998004701 type III secretion system protein SsaT; Provisional; Region: PRK15349 1016998004702 type III secretion system protein SsaS; Provisional; Region: PRK15350 1016998004703 Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790 1016998004704 type III secretion system protein SsaQ; Validated; Region: PRK08035 1016998004705 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 1016998004706 type III secretion system protein SsaP; Provisional; Region: PRK15351 1016998004707 type III secretion system protein SsaO; Provisional; Region: PRK15352 1016998004708 type III secretion system ATPase SsaN; Validated; Region: PRK07594 1016998004709 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1016998004710 Walker A motif; other site 1016998004711 ATP binding site [chemical binding]; other site 1016998004712 Walker B motif; other site 1016998004713 secretion system apparatus protein SsaV; Provisional; Region: PRK12720 1016998004714 FHIPEP family; Region: FHIPEP; pfam00771 1016998004715 type III secretion system protein SsaM; Provisional; Region: PRK15353 1016998004716 type III secretion system protein SsaL; Provisional; Region: PRK15345 1016998004717 HrpJ-like domain; Region: HrpJ; pfam07201 1016998004718 TyeA; Region: TyeA; cl07611 1016998004719 type III secretion system protein SsaK; Provisional; Region: PRK15354 1016998004720 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 1016998004721 Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327 1016998004722 type III secretion system lipoprotein SsaJ; Provisional; Region: PRK15348 1016998004723 type III secretion system protein SsaI; Provisional; Region: PRK15355 1016998004724 type III secretion system protein SsaH; Provisional; Region: PRK15356 1016998004725 type III secretion system needle protein SsaG; Provisional; Region: PRK15344 1016998004726 pathogenicity island 2 effector protein SseG; Provisional; Region: PRK15357 1016998004727 pathogenicity island 2 effector protein SseF; Provisional; Region: PRK15358 1016998004728 type III secretion system chaperone protein SscB; Provisional; Region: PRK15359 1016998004729 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1016998004730 TPR motif; other site 1016998004731 binding surface 1016998004732 pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360 1016998004733 pathogenicity island 2 effector protein SseD; Provisional; Region: PRK15361 1016998004734 pathogenicity island 2 effector protein SseC; Provisional; Region: PRK15362 1016998004735 pathogenicity island 2 chaperone protein SscA; Provisional; Region: PRK15363 1016998004736 pathogenicity island 2 effector protein SseB; Provisional; Region: PRK15364 1016998004737 type III secretion system chaperone SseA; Provisional; Region: PRK15365 1016998004738 type III secretion system chaperone SsaE; Provisional; Region: PRK15366 1016998004739 type III secretion system protein SsaD; Provisional; Region: PRK15367 1016998004740 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 1016998004741 outer membrane secretin SsaC; Provisional; Region: PRK15346 1016998004742 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1016998004743 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1016998004744 pathogenicity island chaperone protein SpiC; Provisional; Region: PRK15368 1016998004745 two component system sensor kinase SsrA; Provisional; Region: PRK15347 1016998004746 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1016998004747 dimerization interface [polypeptide binding]; other site 1016998004748 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1016998004749 dimer interface [polypeptide binding]; other site 1016998004750 phosphorylation site [posttranslational modification] 1016998004751 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1016998004752 ATP binding site [chemical binding]; other site 1016998004753 Mg2+ binding site [ion binding]; other site 1016998004754 G-X-G motif; other site 1016998004755 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1016998004756 active site 1016998004757 phosphorylation site [posttranslational modification] 1016998004758 intermolecular recognition site; other site 1016998004759 dimerization interface [polypeptide binding]; other site 1016998004760 two component system sensor kinase SsrB; Provisional; Region: PRK15369 1016998004761 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1016998004762 active site 1016998004763 phosphorylation site [posttranslational modification] 1016998004764 intermolecular recognition site; other site 1016998004765 dimerization interface [polypeptide binding]; other site 1016998004766 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1016998004767 DNA binding residues [nucleotide binding] 1016998004768 dimerization interface [polypeptide binding]; other site 1016998004769 transcriptional regulator MirA; Provisional; Region: PRK15043 1016998004770 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1016998004771 DNA binding residues [nucleotide binding] 1016998004772 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1016998004773 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1016998004774 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 1016998004775 hypothetical protein; Provisional; Region: PRK10292 1016998004776 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1016998004777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1016998004778 active site 1016998004779 phosphorylation site [posttranslational modification] 1016998004780 intermolecular recognition site; other site 1016998004781 dimerization interface [polypeptide binding]; other site 1016998004782 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1016998004783 DNA binding residues [nucleotide binding] 1016998004784 dimerization interface [polypeptide binding]; other site 1016998004785 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1016998004786 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1016998004787 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1016998004788 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1016998004789 dimer interface [polypeptide binding]; other site 1016998004790 phosphorylation site [posttranslational modification] 1016998004791 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1016998004792 ATP binding site [chemical binding]; other site 1016998004793 Mg2+ binding site [ion binding]; other site 1016998004794 G-X-G motif; other site 1016998004795 tetrathionate reductase subunit B; Provisional; Region: PRK14993 1016998004796 4Fe-4S binding domain; Region: Fer4; pfam00037 1016998004797 tetrathionate reductase subunit C; Provisional; Region: PRK14992 1016998004798 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1016998004799 tetrathionate reductase subunit A; Provisional; Region: PRK14991 1016998004800 The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758 1016998004801 putative [Fe4-S4] binding site [ion binding]; other site 1016998004802 putative molybdopterin cofactor binding site [chemical binding]; other site 1016998004803 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 1016998004804 putative molybdopterin cofactor binding site; other site 1016998004805 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1016998004806 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1016998004807 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1016998004808 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1016998004809 substrate binding site [chemical binding]; other site 1016998004810 dimer interface [polypeptide binding]; other site 1016998004811 ATP binding site [chemical binding]; other site 1016998004812 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1016998004813 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1016998004814 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1016998004815 pyruvate kinase; Provisional; Region: PRK09206 1016998004816 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1016998004817 domain interfaces; other site 1016998004818 active site 1016998004819 murein lipoprotein; Provisional; Region: PRK15396 1016998004820 L,D-transpeptidase; Provisional; Region: PRK10190 1016998004821 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1016998004822 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1016998004823 cysteine desufuration protein SufE; Provisional; Region: PRK09296 1016998004824 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1016998004825 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1016998004826 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1016998004827 catalytic residue [active] 1016998004828 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 1016998004829 FeS assembly protein SufD; Region: sufD; TIGR01981 1016998004830 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 1016998004831 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1016998004832 Walker A/P-loop; other site 1016998004833 ATP binding site [chemical binding]; other site 1016998004834 Q-loop/lid; other site 1016998004835 ABC transporter signature motif; other site 1016998004836 Walker B; other site 1016998004837 D-loop; other site 1016998004838 H-loop/switch region; other site 1016998004839 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1016998004840 putative ABC transporter; Region: ycf24; CHL00085 1016998004841 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 1016998004842 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1016998004843 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1016998004844 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1016998004845 CoenzymeA binding site [chemical binding]; other site 1016998004846 subunit interaction site [polypeptide binding]; other site 1016998004847 PHB binding site; other site 1016998004848 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1016998004849 FAD binding domain; Region: FAD_binding_4; pfam01565 1016998004850 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1016998004851 putative inner membrane protein; Provisional; Region: PRK10983 1016998004852 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1016998004853 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 1016998004854 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998004855 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1016998004856 putative substrate translocation pore; other site 1016998004857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998004858 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1016998004859 putative substrate translocation pore; other site 1016998004860 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 1016998004861 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1016998004862 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1016998004863 shikimate binding site; other site 1016998004864 NAD(P) binding site [chemical binding]; other site 1016998004865 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1016998004866 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1016998004867 active site 1016998004868 catalytic residue [active] 1016998004869 dimer interface [polypeptide binding]; other site 1016998004870 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 1016998004871 Coenzyme A transferase; Region: CoA_trans; smart00882 1016998004872 Coenzyme A transferase; Region: CoA_trans; cl17247 1016998004873 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 1016998004874 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1016998004875 active site 1016998004876 Cupin domain; Region: Cupin_2; pfam07883 1016998004877 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1016998004878 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1016998004879 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1016998004880 Ligand binding site [chemical binding]; other site 1016998004881 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1016998004882 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 1016998004883 Electron transfer flavoprotein domain; Region: ETF; smart00893 1016998004884 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1016998004885 oxidoreductase; Provisional; Region: PRK10015 1016998004886 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 1016998004887 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 1016998004888 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 1016998004889 acyl-activating enzyme (AAE) consensus motif; other site 1016998004890 putative AMP binding site [chemical binding]; other site 1016998004891 putative active site [active] 1016998004892 putative CoA binding site [chemical binding]; other site 1016998004893 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1016998004894 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1016998004895 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1016998004896 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1016998004897 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1016998004898 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 1016998004899 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1016998004900 hypothetical protein; Provisional; Region: PRK10183 1016998004901 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1016998004902 hypothetical protein; Validated; Region: PRK00029 1016998004903 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 1016998004904 NlpC/P60 family; Region: NLPC_P60; pfam00877 1016998004905 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 1016998004906 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1016998004907 Walker A/P-loop; other site 1016998004908 ATP binding site [chemical binding]; other site 1016998004909 Q-loop/lid; other site 1016998004910 ABC transporter signature motif; other site 1016998004911 Walker B; other site 1016998004912 D-loop; other site 1016998004913 H-loop/switch region; other site 1016998004914 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1016998004915 catalytic residues [active] 1016998004916 dimer interface [polypeptide binding]; other site 1016998004917 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1016998004918 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1016998004919 ABC-ATPase subunit interface; other site 1016998004920 dimer interface [polypeptide binding]; other site 1016998004921 putative PBP binding regions; other site 1016998004922 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1016998004923 IHF dimer interface [polypeptide binding]; other site 1016998004924 IHF - DNA interface [nucleotide binding]; other site 1016998004925 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1016998004926 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1016998004927 putative tRNA-binding site [nucleotide binding]; other site 1016998004928 B3/4 domain; Region: B3_4; pfam03483 1016998004929 tRNA synthetase B5 domain; Region: B5; smart00874 1016998004930 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1016998004931 dimer interface [polypeptide binding]; other site 1016998004932 motif 1; other site 1016998004933 motif 3; other site 1016998004934 motif 2; other site 1016998004935 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1016998004936 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1016998004937 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1016998004938 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1016998004939 dimer interface [polypeptide binding]; other site 1016998004940 motif 1; other site 1016998004941 active site 1016998004942 motif 2; other site 1016998004943 motif 3; other site 1016998004944 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1016998004945 23S rRNA binding site [nucleotide binding]; other site 1016998004946 L21 binding site [polypeptide binding]; other site 1016998004947 L13 binding site [polypeptide binding]; other site 1016998004948 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1016998004949 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1016998004950 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1016998004951 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1016998004952 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1016998004953 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1016998004954 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1016998004955 active site 1016998004956 dimer interface [polypeptide binding]; other site 1016998004957 motif 1; other site 1016998004958 motif 2; other site 1016998004959 motif 3; other site 1016998004960 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1016998004961 anticodon binding site; other site 1016998004962 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 1016998004963 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1016998004964 active site 1016998004965 substrate binding site [chemical binding]; other site 1016998004966 Mg2+ binding site [ion binding]; other site 1016998004967 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528 1016998004968 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 1016998004969 6-phosphofructokinase 2; Provisional; Region: PRK10294 1016998004970 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1016998004971 putative substrate binding site [chemical binding]; other site 1016998004972 putative ATP binding site [chemical binding]; other site 1016998004973 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 1016998004974 Phosphotransferase enzyme family; Region: APH; pfam01636 1016998004975 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1016998004976 active site 1016998004977 ATP binding site [chemical binding]; other site 1016998004978 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1016998004979 YniB-like protein; Region: YniB; pfam14002 1016998004980 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 1016998004981 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1016998004982 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1016998004983 motif II; other site 1016998004984 inner membrane protein; Provisional; Region: PRK11648 1016998004985 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1016998004986 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1016998004987 cell division modulator; Provisional; Region: PRK10113 1016998004988 hydroperoxidase II; Provisional; Region: katE; PRK11249 1016998004989 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1016998004990 tetramer interface [polypeptide binding]; other site 1016998004991 heme binding pocket [chemical binding]; other site 1016998004992 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1016998004993 domain interactions; other site 1016998004994 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 1016998004995 putative active site [active] 1016998004996 YdjC motif; other site 1016998004997 Mg binding site [ion binding]; other site 1016998004998 putative homodimer interface [polypeptide binding]; other site 1016998004999 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1016998005000 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1016998005001 NAD binding site [chemical binding]; other site 1016998005002 sugar binding site [chemical binding]; other site 1016998005003 divalent metal binding site [ion binding]; other site 1016998005004 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1016998005005 dimer interface [polypeptide binding]; other site 1016998005006 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 1016998005007 Cupin domain; Region: Cupin_2; pfam07883 1016998005008 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1016998005009 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1016998005010 methionine cluster; other site 1016998005011 active site 1016998005012 phosphorylation site [posttranslational modification] 1016998005013 metal binding site [ion binding]; metal-binding site 1016998005014 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 1016998005015 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1016998005016 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1016998005017 active site 1016998005018 P-loop; other site 1016998005019 phosphorylation site [posttranslational modification] 1016998005020 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 1016998005021 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1016998005022 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1016998005023 homodimer interface [polypeptide binding]; other site 1016998005024 NAD binding pocket [chemical binding]; other site 1016998005025 ATP binding pocket [chemical binding]; other site 1016998005026 Mg binding site [ion binding]; other site 1016998005027 active-site loop [active] 1016998005028 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 1016998005029 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1016998005030 GIY-YIG motif/motif A; other site 1016998005031 active site 1016998005032 catalytic site [active] 1016998005033 putative DNA binding site [nucleotide binding]; other site 1016998005034 metal binding site [ion binding]; metal-binding site 1016998005035 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1016998005036 dimer interface [polypeptide binding]; other site 1016998005037 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 1016998005038 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1016998005039 putative active site [active] 1016998005040 Zn binding site [ion binding]; other site 1016998005041 succinylarginine dihydrolase; Provisional; Region: PRK13281 1016998005042 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 1016998005043 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 1016998005044 NAD(P) binding site [chemical binding]; other site 1016998005045 catalytic residues [active] 1016998005046 arginine succinyltransferase; Provisional; Region: PRK10456 1016998005047 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1016998005048 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 1016998005049 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1016998005050 inhibitor-cofactor binding pocket; inhibition site 1016998005051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998005052 catalytic residue [active] 1016998005053 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1016998005054 putative catalytic site [active] 1016998005055 putative phosphate binding site [ion binding]; other site 1016998005056 active site 1016998005057 metal binding site A [ion binding]; metal-binding site 1016998005058 DNA binding site [nucleotide binding] 1016998005059 putative AP binding site [nucleotide binding]; other site 1016998005060 putative metal binding site B [ion binding]; other site 1016998005061 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1016998005062 active site 1016998005063 8-oxo-dGMP binding site [chemical binding]; other site 1016998005064 nudix motif; other site 1016998005065 metal binding site [ion binding]; metal-binding site 1016998005066 glutamate dehydrogenase; Provisional; Region: PRK09414 1016998005067 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1016998005068 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1016998005069 NAD(P) binding site [chemical binding]; other site 1016998005070 DNA topoisomerase III; Provisional; Region: PRK07726 1016998005071 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1016998005072 active site 1016998005073 putative interdomain interaction site [polypeptide binding]; other site 1016998005074 putative metal-binding site [ion binding]; other site 1016998005075 putative nucleotide binding site [chemical binding]; other site 1016998005076 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1016998005077 domain I; other site 1016998005078 DNA binding groove [nucleotide binding] 1016998005079 phosphate binding site [ion binding]; other site 1016998005080 domain II; other site 1016998005081 domain III; other site 1016998005082 nucleotide binding site [chemical binding]; other site 1016998005083 catalytic site [active] 1016998005084 domain IV; other site 1016998005085 selenophosphate synthetase; Provisional; Region: PRK00943 1016998005086 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1016998005087 dimerization interface [polypeptide binding]; other site 1016998005088 putative ATP binding site [chemical binding]; other site 1016998005089 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1016998005090 putative FMN binding site [chemical binding]; other site 1016998005091 protease 4; Provisional; Region: PRK10949 1016998005092 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1016998005093 tandem repeat interface [polypeptide binding]; other site 1016998005094 oligomer interface [polypeptide binding]; other site 1016998005095 active site residues [active] 1016998005096 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 1016998005097 tandem repeat interface [polypeptide binding]; other site 1016998005098 oligomer interface [polypeptide binding]; other site 1016998005099 active site residues [active] 1016998005100 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1016998005101 active site 1016998005102 homodimer interface [polypeptide binding]; other site 1016998005103 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1016998005104 Isochorismatase family; Region: Isochorismatase; pfam00857 1016998005105 catalytic triad [active] 1016998005106 metal binding site [ion binding]; metal-binding site 1016998005107 conserved cis-peptide bond; other site 1016998005108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 1016998005109 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1016998005110 SelR domain; Region: SelR; pfam01641 1016998005111 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1016998005112 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1016998005113 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1016998005114 active site 1016998005115 phosphate binding residues; other site 1016998005116 catalytic residues [active] 1016998005117 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1016998005118 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1016998005119 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1016998005120 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1016998005121 PrkA family serine protein kinase; Provisional; Region: PRK15455 1016998005122 AAA ATPase domain; Region: AAA_16; pfam13191 1016998005123 Walker A motif; other site 1016998005124 ATP binding site [chemical binding]; other site 1016998005125 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1016998005126 hypothetical protein; Provisional; Region: PRK05325 1016998005127 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1016998005128 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1016998005129 metal binding site [ion binding]; metal-binding site 1016998005130 active site 1016998005131 I-site; other site 1016998005132 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 1016998005133 putative deacylase active site [active] 1016998005134 Predicted membrane protein [Function unknown]; Region: COG2707 1016998005135 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1016998005136 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1016998005137 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1016998005138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998005139 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1016998005140 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 1016998005141 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1016998005142 hypothetical protein; Provisional; Region: PRK10457 1016998005143 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 1016998005144 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 1016998005145 Uncharacterized protein family (UPF0160); Region: UPF0160; cl01749 1016998005146 leucine export protein LeuE; Provisional; Region: PRK10958 1016998005147 chorismate mutase; Provisional; Region: PRK08055 1016998005148 phosphatidylcholine-sterol O-acyltransferase; Region: PLN02733 1016998005149 Pleckstrin homology-like domain; Region: PH-like; cl17171 1016998005150 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 1016998005151 transcriptional regulator MirA; Provisional; Region: PRK15043 1016998005152 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1016998005153 DNA binding residues [nucleotide binding] 1016998005154 dimer interface [polypeptide binding]; other site 1016998005155 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1016998005156 DNA binding residues [nucleotide binding] 1016998005157 aminoglycoside resistance protein; Provisional; Region: PRK13746 1016998005158 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1016998005159 active site 1016998005160 NTP binding site [chemical binding]; other site 1016998005161 metal binding triad [ion binding]; metal-binding site 1016998005162 antibiotic binding site [chemical binding]; other site 1016998005163 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 1016998005164 zinc/cadmium-binding protein; Provisional; Region: PRK10306 1016998005165 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1016998005166 dimerization interface [polypeptide binding]; other site 1016998005167 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1016998005168 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1016998005169 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1016998005170 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 1016998005171 Walker A/P-loop; other site 1016998005172 ATP binding site [chemical binding]; other site 1016998005173 Q-loop/lid; other site 1016998005174 ABC transporter signature motif; other site 1016998005175 Walker B; other site 1016998005176 D-loop; other site 1016998005177 H-loop/switch region; other site 1016998005178 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1016998005179 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1016998005180 Walker A/P-loop; other site 1016998005181 ATP binding site [chemical binding]; other site 1016998005182 Q-loop/lid; other site 1016998005183 ABC transporter signature motif; other site 1016998005184 Walker B; other site 1016998005185 D-loop; other site 1016998005186 H-loop/switch region; other site 1016998005187 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1016998005188 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998005189 dimer interface [polypeptide binding]; other site 1016998005190 conserved gate region; other site 1016998005191 putative PBP binding loops; other site 1016998005192 ABC-ATPase subunit interface; other site 1016998005193 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1016998005194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998005195 dimer interface [polypeptide binding]; other site 1016998005196 conserved gate region; other site 1016998005197 ABC-ATPase subunit interface; other site 1016998005198 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 1016998005199 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1016998005200 TRL-like protein family; Region: TRL; pfam13146 1016998005201 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1016998005202 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 1016998005203 BNR repeat-like domain; Region: BNR_2; pfam13088 1016998005204 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1016998005205 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1016998005206 putative dimer interface [polypeptide binding]; other site 1016998005207 lysozyme inhibitor; Provisional; Region: PRK13791 1016998005208 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1016998005209 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1016998005210 DNA-binding site [nucleotide binding]; DNA binding site 1016998005211 RNA-binding motif; other site 1016998005212 Ricin-type beta-trefoil; Region: RICIN; smart00458 1016998005213 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1016998005214 putative sugar binding sites [chemical binding]; other site 1016998005215 Q-X-W motif; other site 1016998005216 DinI-like family; Region: DinI; pfam06183 1016998005217 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 1016998005218 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1016998005219 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1016998005220 hypothetical protein; Provisional; Region: PRK09951 1016998005221 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1016998005222 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1016998005223 substrate binding pocket [chemical binding]; other site 1016998005224 membrane-bound complex binding site; other site 1016998005225 hinge residues; other site 1016998005226 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1016998005227 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 1016998005228 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 1016998005229 Phage protein GP46; Region: GP46; pfam07409 1016998005230 Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; pfam06890 1016998005231 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 1016998005232 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1016998005233 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 1016998005234 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 1016998005235 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1016998005236 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1016998005237 Phage tail tube protein; Region: Tail_tube; pfam10618 1016998005238 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 1016998005239 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 1016998005240 Protein of unknown function (DUF2635); Region: DUF2635; pfam10948 1016998005241 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 1016998005242 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1016998005243 oligomerization interface [polypeptide binding]; other site 1016998005244 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1016998005245 Phage capsid family; Region: Phage_capsid; pfam05065 1016998005246 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 1016998005247 Phage-related protein [Function unknown]; Region: COG4695 1016998005248 Phage portal protein; Region: Phage_portal; pfam04860 1016998005249 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1016998005250 Phage terminase, small subunit; Region: Terminase_4; pfam05119 1016998005251 Predicted chitinase [General function prediction only]; Region: COG3179 1016998005252 catalytic residue [active] 1016998005253 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 1016998005254 Antitermination protein; Region: Antiterm; pfam03589 1016998005255 Antitermination protein; Region: Antiterm; pfam03589 1016998005256 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 1016998005257 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 1016998005258 DinI-like family; Region: DinI; pfam06183 1016998005259 ORF6N domain; Region: ORF6N; pfam10543 1016998005260 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 1016998005261 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 1016998005262 putative replication protein; Provisional; Region: PRK12377 1016998005263 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1016998005264 Walker A motif; other site 1016998005265 ATP binding site [chemical binding]; other site 1016998005266 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1016998005267 Protein of unknown function (DUF1376); Region: DUF1376; cl01531 1016998005268 primosomal protein DnaI; Provisional; Region: PRK02854 1016998005269 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 1016998005270 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 1016998005271 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1016998005272 non-specific DNA binding site [nucleotide binding]; other site 1016998005273 transcriptional repressor DicA; Reviewed; Region: PRK09706 1016998005274 sequence-specific DNA binding site [nucleotide binding]; other site 1016998005275 salt bridge; other site 1016998005276 exonuclease VIII; Reviewed; Region: PRK09709 1016998005277 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 1016998005278 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 1016998005279 RecT family; Region: RecT; pfam03837 1016998005280 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 1016998005281 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 1016998005282 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 1016998005283 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1016998005284 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 1016998005285 Int/Topo IB signature motif; other site 1016998005286 DinI-like family; Region: DinI; cl11630 1016998005287 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1016998005288 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1016998005289 substrate binding pocket [chemical binding]; other site 1016998005290 membrane-bound complex binding site; other site 1016998005291 hinge residues; other site 1016998005292 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1016998005293 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 1016998005294 Baseplate J-like protein; Region: Baseplate_J; cl01294 1016998005295 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1016998005296 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 1016998005297 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1016998005298 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1016998005299 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1016998005300 catalytic residue [active] 1016998005301 Protein of unknown function (DUF3277); Region: DUF3277; pfam11681 1016998005302 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 1016998005303 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 1016998005304 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834 1016998005305 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 1016998005306 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 1016998005307 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1016998005308 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 1016998005309 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 1016998005310 Phage terminase large subunit; Region: Terminase_3; cl12054 1016998005311 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 1016998005312 Predicted chitinase [General function prediction only]; Region: COG3179 1016998005313 Protein of unknown function (DUF754); Region: DUF754; pfam05449 1016998005314 Antitermination protein; Region: Antiterm; pfam03589 1016998005315 Antitermination protein; Region: Antiterm; pfam03589 1016998005316 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 1016998005317 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 1016998005318 Protein of unknown function (DUF1076); Region: DUF1076; pfam06416 1016998005319 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 1016998005320 Replication protein P; Region: Phage_lambda_P; pfam06992 1016998005321 Protein of unknown function (DUF1376); Region: DUF1376; cl01531 1016998005322 primosomal protein DnaI; Provisional; Region: PRK02854 1016998005323 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 1016998005324 transcriptional repressor DicA; Reviewed; Region: PRK09706 1016998005325 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 1016998005326 exonuclease VIII; Reviewed; Region: PRK09709 1016998005327 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 1016998005328 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 1016998005329 recombination and repair protein RecT; Reviewed; Region: recT; PRK09846 1016998005330 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 1016998005331 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1016998005332 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 1016998005333 dimer interface [polypeptide binding]; other site 1016998005334 active site 1016998005335 Int/Topo IB signature motif; other site 1016998005336 isocitrate dehydrogenase; Validated; Region: PRK07362 1016998005337 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1016998005338 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 1016998005339 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 1016998005340 probable active site [active] 1016998005341 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 1016998005342 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1016998005343 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 1016998005344 nudix motif; other site 1016998005345 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1016998005346 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 1016998005347 putative lysogenization regulator; Reviewed; Region: PRK00218 1016998005348 adenylosuccinate lyase; Provisional; Region: PRK09285 1016998005349 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1016998005350 tetramer interface [polypeptide binding]; other site 1016998005351 active site 1016998005352 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 1016998005353 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1016998005354 active site 1016998005355 phosphorylation site [posttranslational modification] 1016998005356 intermolecular recognition site; other site 1016998005357 dimerization interface [polypeptide binding]; other site 1016998005358 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1016998005359 DNA binding site [nucleotide binding] 1016998005360 sensor protein PhoQ; Provisional; Region: PRK10815 1016998005361 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 1016998005362 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1016998005363 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1016998005364 ATP binding site [chemical binding]; other site 1016998005365 Mg2+ binding site [ion binding]; other site 1016998005366 G-X-G motif; other site 1016998005367 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1016998005368 Cupin domain; Region: Cupin_2; cl17218 1016998005369 peptidase T; Region: peptidase-T; TIGR01882 1016998005370 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1016998005371 metal binding site [ion binding]; metal-binding site 1016998005372 dimer interface [polypeptide binding]; other site 1016998005373 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 1016998005374 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1016998005375 Walker A/P-loop; other site 1016998005376 ATP binding site [chemical binding]; other site 1016998005377 Q-loop/lid; other site 1016998005378 ABC transporter signature motif; other site 1016998005379 Walker B; other site 1016998005380 D-loop; other site 1016998005381 H-loop/switch region; other site 1016998005382 TOBE domain; Region: TOBE_2; pfam08402 1016998005383 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1016998005384 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998005385 dimer interface [polypeptide binding]; other site 1016998005386 conserved gate region; other site 1016998005387 putative PBP binding loops; other site 1016998005388 ABC-ATPase subunit interface; other site 1016998005389 Sif protein; Region: Sif; pfam06767 1016998005390 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1016998005391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998005392 dimer interface [polypeptide binding]; other site 1016998005393 conserved gate region; other site 1016998005394 putative PBP binding loops; other site 1016998005395 ABC-ATPase subunit interface; other site 1016998005396 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 1016998005397 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1016998005398 NAD-dependent deacetylase; Provisional; Region: PRK00481 1016998005399 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1016998005400 NAD+ binding site [chemical binding]; other site 1016998005401 substrate binding site [chemical binding]; other site 1016998005402 Zn binding site [ion binding]; other site 1016998005403 fructokinase; Reviewed; Region: PRK09557 1016998005404 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1016998005405 nucleotide binding site [chemical binding]; other site 1016998005406 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 1016998005407 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1016998005408 FtsX-like permease family; Region: FtsX; pfam02687 1016998005409 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 1016998005410 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1016998005411 Walker A/P-loop; other site 1016998005412 ATP binding site [chemical binding]; other site 1016998005413 Q-loop/lid; other site 1016998005414 ABC transporter signature motif; other site 1016998005415 Walker B; other site 1016998005416 D-loop; other site 1016998005417 H-loop/switch region; other site 1016998005418 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 1016998005419 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1016998005420 FtsX-like permease family; Region: FtsX; pfam02687 1016998005421 transcription-repair coupling factor; Provisional; Region: PRK10689 1016998005422 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1016998005423 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1016998005424 ATP binding site [chemical binding]; other site 1016998005425 putative Mg++ binding site [ion binding]; other site 1016998005426 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1016998005427 nucleotide binding region [chemical binding]; other site 1016998005428 ATP-binding site [chemical binding]; other site 1016998005429 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1016998005430 L,D-transpeptidase; Provisional; Region: PRK10190 1016998005431 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1016998005432 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1016998005433 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1016998005434 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1016998005435 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1016998005436 hypothetical protein; Provisional; Region: PRK11280 1016998005437 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1016998005438 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1016998005439 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1016998005440 hypothetical protein; Provisional; Region: PRK04940 1016998005441 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1016998005442 beta-hexosaminidase; Provisional; Region: PRK05337 1016998005443 thiamine kinase; Region: ycfN_thiK; TIGR02721 1016998005444 thiamine kinase; Provisional; Region: thiK; PRK10271 1016998005445 substrate binding site [chemical binding]; other site 1016998005446 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 1016998005447 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 1016998005448 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 1016998005449 putative dimer interface [polypeptide binding]; other site 1016998005450 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1016998005451 nucleotide binding site/active site [active] 1016998005452 HIT family signature motif; other site 1016998005453 catalytic residue [active] 1016998005454 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 1016998005455 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1016998005456 N-terminal plug; other site 1016998005457 ligand-binding site [chemical binding]; other site 1016998005458 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 1016998005459 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1016998005460 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1016998005461 active site turn [active] 1016998005462 phosphorylation site [posttranslational modification] 1016998005463 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1016998005464 active site 1016998005465 DNA polymerase III subunit delta'; Validated; Region: PRK07993 1016998005466 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 1016998005467 thymidylate kinase; Validated; Region: tmk; PRK00698 1016998005468 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1016998005469 TMP-binding site; other site 1016998005470 ATP-binding site [chemical binding]; other site 1016998005471 conserved hypothetical protein, YceG family; Region: TIGR00247 1016998005472 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1016998005473 dimerization interface [polypeptide binding]; other site 1016998005474 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1016998005475 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1016998005476 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998005477 catalytic residue [active] 1016998005478 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1016998005479 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1016998005480 dimer interface [polypeptide binding]; other site 1016998005481 active site 1016998005482 acyl carrier protein; Provisional; Region: acpP; PRK00982 1016998005483 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1016998005484 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1016998005485 NAD(P) binding site [chemical binding]; other site 1016998005486 homotetramer interface [polypeptide binding]; other site 1016998005487 homodimer interface [polypeptide binding]; other site 1016998005488 active site 1016998005489 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1016998005490 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1016998005491 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1016998005492 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1016998005493 dimer interface [polypeptide binding]; other site 1016998005494 active site 1016998005495 CoA binding pocket [chemical binding]; other site 1016998005496 putative phosphate acyltransferase; Provisional; Region: PRK05331 1016998005497 hypothetical protein; Provisional; Region: PRK11193 1016998005498 Maf-like protein; Region: Maf; pfam02545 1016998005499 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1016998005500 active site 1016998005501 dimer interface [polypeptide binding]; other site 1016998005502 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 1016998005503 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1016998005504 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1016998005505 RNA binding surface [nucleotide binding]; other site 1016998005506 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1016998005507 active site 1016998005508 RNase E 5' UTR element 1016998005509 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1016998005510 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1016998005511 homodimer interface [polypeptide binding]; other site 1016998005512 oligonucleotide binding site [chemical binding]; other site 1016998005513 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 1016998005514 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 1016998005515 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1016998005516 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 1016998005517 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1016998005518 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 1016998005519 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 1016998005520 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1016998005521 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1016998005522 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1016998005523 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 1016998005524 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12696 1016998005525 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1016998005526 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1016998005527 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1016998005528 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 1016998005529 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1016998005530 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1016998005531 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1016998005532 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1016998005533 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1016998005534 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1016998005535 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 1016998005536 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1016998005537 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1016998005538 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1016998005539 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1016998005540 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1016998005541 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1016998005542 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1016998005543 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 1016998005544 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1016998005545 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1016998005546 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 1016998005547 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 1016998005548 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1016998005549 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1016998005550 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1016998005551 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1016998005552 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1016998005553 hypothetical protein; Provisional; Region: PRK11239 1016998005554 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 1016998005555 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 1016998005556 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1016998005557 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1016998005558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998005559 putative substrate translocation pore; other site 1016998005560 glutaredoxin 2; Provisional; Region: PRK10387 1016998005561 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 1016998005562 C-terminal domain interface [polypeptide binding]; other site 1016998005563 GSH binding site (G-site) [chemical binding]; other site 1016998005564 catalytic residues [active] 1016998005565 putative dimer interface [polypeptide binding]; other site 1016998005566 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 1016998005567 N-terminal domain interface [polypeptide binding]; other site 1016998005568 lipoprotein; Provisional; Region: PRK10598 1016998005569 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1016998005570 active site 1016998005571 substrate binding pocket [chemical binding]; other site 1016998005572 dimer interface [polypeptide binding]; other site 1016998005573 DNA damage-inducible protein I; Provisional; Region: PRK10597 1016998005574 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 1016998005575 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1016998005576 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1016998005577 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1016998005578 hypothetical protein; Provisional; Region: PRK03757 1016998005579 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1016998005580 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1016998005581 active site residue [active] 1016998005582 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1016998005583 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1016998005584 putative acyl-acceptor binding pocket; other site 1016998005585 drug efflux system protein MdtG; Provisional; Region: PRK09874 1016998005586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998005587 putative substrate translocation pore; other site 1016998005588 secY/secA suppressor protein; Provisional; Region: PRK11467 1016998005589 lipoprotein; Provisional; Region: PRK10175 1016998005590 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1016998005591 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 1016998005592 Ligand binding site; other site 1016998005593 DXD motif; other site 1016998005594 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 1016998005595 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 1016998005596 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1016998005597 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1016998005598 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1016998005599 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 1016998005600 putative active site [active] 1016998005601 catalytic site [active] 1016998005602 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 1016998005603 putative active site [active] 1016998005604 catalytic site [active] 1016998005605 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1016998005606 putative ADP-ribose binding site [chemical binding]; other site 1016998005607 putative active site [active] 1016998005608 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1016998005609 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 1016998005610 major curlin subunit; Provisional; Region: csgA; PRK10051 1016998005611 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1016998005612 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 1016998005613 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1016998005614 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1016998005615 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 1016998005616 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1016998005617 DNA binding residues [nucleotide binding] 1016998005618 dimerization interface [polypeptide binding]; other site 1016998005619 curli assembly protein CsgE; Provisional; Region: PRK10386 1016998005620 curli assembly protein CsgF; Provisional; Region: PRK10050 1016998005621 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 1016998005622 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 1016998005623 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 1016998005624 putative hydrolase; Validated; Region: PRK09248 1016998005625 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 1016998005626 active site 1016998005627 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 1016998005628 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1016998005629 putative ligand binding site [chemical binding]; other site 1016998005630 NAD binding site [chemical binding]; other site 1016998005631 dimerization interface [polypeptide binding]; other site 1016998005632 catalytic site [active] 1016998005633 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1016998005634 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1016998005635 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1016998005636 putative sialic acid transporter; Provisional; Region: PRK12307 1016998005637 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998005638 putative substrate translocation pore; other site 1016998005639 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178 1016998005640 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 1016998005641 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 1016998005642 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1016998005643 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1016998005644 putative active site cavity [active] 1016998005645 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 1016998005646 Na binding site [ion binding]; other site 1016998005647 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1016998005648 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1016998005649 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1016998005650 putative active site [active] 1016998005651 hypothetical protein; Provisional; Region: PRK10536 1016998005652 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1016998005653 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1016998005654 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1016998005655 Na binding site [ion binding]; other site 1016998005656 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 1016998005657 Predicted transcriptional regulator [Transcription]; Region: COG3905 1016998005658 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1016998005659 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1016998005660 Glutamate binding site [chemical binding]; other site 1016998005661 NAD binding site [chemical binding]; other site 1016998005662 catalytic residues [active] 1016998005663 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 1016998005664 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 1016998005665 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1016998005666 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1016998005667 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 1016998005668 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1016998005669 hypothetical protein; Provisional; Region: PRK10174 1016998005670 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 1016998005671 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1016998005672 catalytic core [active] 1016998005673 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1016998005674 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1016998005675 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1016998005676 catalytic residues [active] 1016998005677 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 1016998005678 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 1016998005679 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1016998005680 catalytic residues [active] 1016998005681 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 1016998005682 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1016998005683 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1016998005684 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1016998005685 DsbD alpha interface [polypeptide binding]; other site 1016998005686 catalytic residues [active] 1016998005687 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1016998005688 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1016998005689 HSP70 interaction site [polypeptide binding]; other site 1016998005690 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1016998005691 substrate binding site [polypeptide binding]; other site 1016998005692 dimer interface [polypeptide binding]; other site 1016998005693 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 1016998005694 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 1016998005695 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1016998005696 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 1016998005697 Cupin domain; Region: Cupin_2; pfam07883 1016998005698 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1016998005699 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998005700 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1016998005701 putative substrate translocation pore; other site 1016998005702 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1016998005703 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 1016998005704 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 1016998005705 putative substrate binding pocket [chemical binding]; other site 1016998005706 trimer interface [polypeptide binding]; other site 1016998005707 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 1016998005708 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1016998005709 putative active site [active] 1016998005710 putative metal binding site [ion binding]; other site 1016998005711 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 1016998005712 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1016998005713 NAD binding site [chemical binding]; other site 1016998005714 catalytic residues [active] 1016998005715 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203 1016998005716 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1016998005717 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1016998005718 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 1016998005719 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1016998005720 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 1016998005721 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1016998005722 4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486 1016998005723 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1016998005724 active site 1016998005725 homotetramer interface [polypeptide binding]; other site 1016998005726 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 1016998005727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1016998005728 active site 1016998005729 phosphorylation site [posttranslational modification] 1016998005730 intermolecular recognition site; other site 1016998005731 dimerization interface [polypeptide binding]; other site 1016998005732 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1016998005733 DNA binding site [nucleotide binding] 1016998005734 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1016998005735 HAMP domain; Region: HAMP; pfam00672 1016998005736 dimerization interface [polypeptide binding]; other site 1016998005737 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1016998005738 dimer interface [polypeptide binding]; other site 1016998005739 phosphorylation site [posttranslational modification] 1016998005740 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1016998005741 ATP binding site [chemical binding]; other site 1016998005742 Mg2+ binding site [ion binding]; other site 1016998005743 G-X-G motif; other site 1016998005744 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 1016998005745 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 1016998005746 inositol phosphate phosphatase SopB; Provisional; Region: PRK15378 1016998005747 Enterobacterial virulence protein IpgD; Region: IpgD; pfam05925 1016998005748 type III secretion chaperone protein SigE; Provisional; Region: PRK15202 1016998005749 secreted effector protein PipB; Provisional; Region: PRK15197 1016998005750 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1016998005751 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1016998005752 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1016998005753 PipA protein; Region: PipA; pfam07108 1016998005754 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1016998005755 YccA-like proteins; Region: YccA_like; cd10433 1016998005756 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1016998005757 sulfur transfer protein TusE; Provisional; Region: PRK11508 1016998005758 acylphosphatase; Provisional; Region: PRK14426 1016998005759 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1016998005760 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1016998005761 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1016998005762 substrate binding site [chemical binding]; other site 1016998005763 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 1016998005764 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 1016998005765 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1016998005766 putative RNA binding site [nucleotide binding]; other site 1016998005767 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1016998005768 S-adenosylmethionine binding site [chemical binding]; other site 1016998005769 heat shock protein HspQ; Provisional; Region: PRK14129 1016998005770 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1016998005771 hypothetical protein; Provisional; Region: PRK03641 1016998005772 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 1016998005773 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1016998005774 active site 1016998005775 dimer interfaces [polypeptide binding]; other site 1016998005776 catalytic residues [active] 1016998005777 DNA helicase IV; Provisional; Region: helD; PRK11054 1016998005778 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 1016998005779 Part of AAA domain; Region: AAA_19; pfam13245 1016998005780 Family description; Region: UvrD_C_2; pfam13538 1016998005781 Predicted membrane protein [Function unknown]; Region: COG3304 1016998005782 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1016998005783 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1016998005784 TIGR01666 family membrane protein; Region: YCCS 1016998005785 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1016998005786 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1016998005787 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 1016998005788 TfoX C-terminal domain; Region: TfoX_C; pfam04994 1016998005789 cell division inhibitor SulA; Region: sula; TIGR00623 1016998005790 outer membrane protein A; Reviewed; Region: PRK10808 1016998005791 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 1016998005792 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1016998005793 ligand binding site [chemical binding]; other site 1016998005794 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 1016998005795 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 1016998005796 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1016998005797 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1016998005798 active site 1 [active] 1016998005799 dimer interface [polypeptide binding]; other site 1016998005800 active site 2 [active] 1016998005801 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 1016998005802 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1016998005803 paraquat-inducible protein B; Provisional; Region: PRK10807 1016998005804 mce related protein; Region: MCE; pfam02470 1016998005805 mce related protein; Region: MCE; pfam02470 1016998005806 mce related protein; Region: MCE; pfam02470 1016998005807 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 1016998005808 Paraquat-inducible protein A; Region: PqiA; pfam04403 1016998005809 Paraquat-inducible protein A; Region: PqiA; pfam04403 1016998005810 ABC transporter ATPase component; Reviewed; Region: PRK11147 1016998005811 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1016998005812 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1016998005813 Walker A/P-loop; other site 1016998005814 Walker A/P-loop; other site 1016998005815 ATP binding site [chemical binding]; other site 1016998005816 ATP binding site [chemical binding]; other site 1016998005817 Q-loop/lid; other site 1016998005818 Q-loop/lid; other site 1016998005819 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1016998005820 ABC transporter signature motif; other site 1016998005821 Walker B; other site 1016998005822 D-loop; other site 1016998005823 ABC transporter; Region: ABC_tran_2; pfam12848 1016998005824 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1016998005825 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1016998005826 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1016998005827 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 1016998005828 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1016998005829 S-adenosylmethionine binding site [chemical binding]; other site 1016998005830 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1016998005831 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1016998005832 MOSC domain; Region: MOSC; pfam03473 1016998005833 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1016998005834 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1016998005835 catalytic loop [active] 1016998005836 iron binding site [ion binding]; other site 1016998005837 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 1016998005838 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1016998005839 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1016998005840 quinone interaction residues [chemical binding]; other site 1016998005841 active site 1016998005842 catalytic residues [active] 1016998005843 FMN binding site [chemical binding]; other site 1016998005844 substrate binding site [chemical binding]; other site 1016998005845 aminopeptidase N; Provisional; Region: pepN; PRK14015 1016998005846 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1016998005847 active site 1016998005848 Zn binding site [ion binding]; other site 1016998005849 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 1016998005850 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 1016998005851 active site 1016998005852 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1016998005853 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1016998005854 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1016998005855 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 1016998005856 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1016998005857 catalytic residue [active] 1016998005858 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1016998005859 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1016998005860 putative DNA binding site [nucleotide binding]; other site 1016998005861 putative Zn2+ binding site [ion binding]; other site 1016998005862 AsnC family; Region: AsnC_trans_reg; pfam01037 1016998005863 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1016998005864 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1016998005865 putative dimer interface [polypeptide binding]; other site 1016998005866 putative anticodon binding site; other site 1016998005867 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1016998005868 homodimer interface [polypeptide binding]; other site 1016998005869 motif 1; other site 1016998005870 motif 2; other site 1016998005871 active site 1016998005872 motif 3; other site 1016998005873 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1016998005874 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1016998005875 trimer interface [polypeptide binding]; other site 1016998005876 eyelet of channel; other site 1016998005877 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1016998005878 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1016998005879 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998005880 homodimer interface [polypeptide binding]; other site 1016998005881 catalytic residue [active] 1016998005882 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1016998005883 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 1016998005884 Peptidase M15; Region: Peptidase_M15_3; cl01194 1016998005885 murein L,D-transpeptidase; Provisional; Region: PRK10594 1016998005886 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1016998005887 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1016998005888 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1016998005889 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 1016998005890 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1016998005891 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1016998005892 condesin subunit E; Provisional; Region: PRK05256 1016998005893 condesin subunit F; Provisional; Region: PRK05260 1016998005894 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1016998005895 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1016998005896 S-adenosylmethionine binding site [chemical binding]; other site 1016998005897 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1016998005898 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1016998005899 putative active site [active] 1016998005900 hypothetical protein; Provisional; Region: PRK10593 1016998005901 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1016998005902 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1016998005903 Ligand binding site; other site 1016998005904 oligomer interface; other site 1016998005905 hypothetical protein; Provisional; Region: PRK11827 1016998005906 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1016998005907 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1016998005908 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1016998005909 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 1016998005910 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 1016998005911 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1016998005912 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1016998005913 Walker A/P-loop; other site 1016998005914 ATP binding site [chemical binding]; other site 1016998005915 Q-loop/lid; other site 1016998005916 ABC transporter signature motif; other site 1016998005917 Walker B; other site 1016998005918 D-loop; other site 1016998005919 H-loop/switch region; other site 1016998005920 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1016998005921 Competence protein; Region: Competence; pfam03772 1016998005922 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1016998005923 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1016998005924 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1016998005925 IHF dimer interface [polypeptide binding]; other site 1016998005926 IHF - DNA interface [nucleotide binding]; other site 1016998005927 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1016998005928 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1016998005929 RNA binding site [nucleotide binding]; other site 1016998005930 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1016998005931 RNA binding site [nucleotide binding]; other site 1016998005932 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 1016998005933 RNA binding site [nucleotide binding]; other site 1016998005934 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 1016998005935 RNA binding site [nucleotide binding]; other site 1016998005936 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1016998005937 RNA binding site [nucleotide binding]; other site 1016998005938 cytidylate kinase; Provisional; Region: cmk; PRK00023 1016998005939 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1016998005940 CMP-binding site; other site 1016998005941 The sites determining sugar specificity; other site 1016998005942 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1016998005943 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1016998005944 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 1016998005945 hinge; other site 1016998005946 active site 1016998005947 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1016998005948 homodimer interface [polypeptide binding]; other site 1016998005949 substrate-cofactor binding pocket; other site 1016998005950 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998005951 catalytic residue [active] 1016998005952 Predicted membrane protein [Function unknown]; Region: COG2323 1016998005953 uncharacterized domain; Region: TIGR00702 1016998005954 YcaO-like family; Region: YcaO; pfam02624 1016998005955 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 1016998005956 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1016998005957 Pyruvate formate lyase 1; Region: PFL1; cd01678 1016998005958 coenzyme A binding site [chemical binding]; other site 1016998005959 active site 1016998005960 catalytic residues [active] 1016998005961 glycine loop; other site 1016998005962 pathogenicity island 1 protein SopD2; Provisional; Region: PRK15380 1016998005963 integrase; Provisional; Region: int; PHA02601 1016998005964 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1016998005965 FeS/SAM binding site; other site 1016998005966 pyruvate formate lyase II activase; Provisional; Region: PRK10076 1016998005967 inner membrane transporter YjeM; Provisional; Region: PRK15238 1016998005968 putative MFS family transporter protein; Provisional; Region: PRK03633 1016998005969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998005970 putative substrate translocation pore; other site 1016998005971 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 1016998005972 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1016998005973 4Fe-4S binding domain; Region: Fer4; pfam00037 1016998005974 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 1016998005975 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1016998005976 putative [Fe4-S4] binding site [ion binding]; other site 1016998005977 putative molybdopterin cofactor binding site [chemical binding]; other site 1016998005978 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1016998005979 putative molybdopterin cofactor binding site; other site 1016998005980 seryl-tRNA synthetase; Provisional; Region: PRK05431 1016998005981 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1016998005982 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1016998005983 dimer interface [polypeptide binding]; other site 1016998005984 active site 1016998005985 motif 1; other site 1016998005986 motif 2; other site 1016998005987 motif 3; other site 1016998005988 recombination factor protein RarA; Reviewed; Region: PRK13342 1016998005989 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1016998005990 Walker A motif; other site 1016998005991 ATP binding site [chemical binding]; other site 1016998005992 Walker B motif; other site 1016998005993 arginine finger; other site 1016998005994 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1016998005995 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 1016998005996 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1016998005997 DNA translocase FtsK; Provisional; Region: PRK10263 1016998005998 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1016998005999 DNA translocase FtsK; Provisional; Region: PRK10263 1016998006000 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1016998006001 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1016998006002 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1016998006003 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1016998006004 putative DNA binding site [nucleotide binding]; other site 1016998006005 putative Zn2+ binding site [ion binding]; other site 1016998006006 AsnC family; Region: AsnC_trans_reg; pfam01037 1016998006007 thioredoxin reductase; Provisional; Region: PRK10262 1016998006008 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1016998006009 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1016998006010 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 1016998006011 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1016998006012 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1016998006013 Walker A/P-loop; other site 1016998006014 ATP binding site [chemical binding]; other site 1016998006015 Q-loop/lid; other site 1016998006016 ABC transporter signature motif; other site 1016998006017 Walker B; other site 1016998006018 D-loop; other site 1016998006019 H-loop/switch region; other site 1016998006020 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 1016998006021 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1016998006022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1016998006023 Walker A/P-loop; other site 1016998006024 ATP binding site [chemical binding]; other site 1016998006025 Q-loop/lid; other site 1016998006026 ABC transporter signature motif; other site 1016998006027 Walker B; other site 1016998006028 D-loop; other site 1016998006029 H-loop/switch region; other site 1016998006030 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1016998006031 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1016998006032 rRNA binding site [nucleotide binding]; other site 1016998006033 predicted 30S ribosome binding site; other site 1016998006034 LysR family transcriptional regulator; Provisional; Region: PRK14997 1016998006035 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998006036 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 1016998006037 putative effector binding pocket; other site 1016998006038 putative dimerization interface [polypeptide binding]; other site 1016998006039 Pirin-related protein [General function prediction only]; Region: COG1741 1016998006040 Pirin; Region: Pirin; pfam02678 1016998006041 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1016998006042 Isochorismatase family; Region: Isochorismatase; pfam00857 1016998006043 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1016998006044 catalytic triad [active] 1016998006045 dimer interface [polypeptide binding]; other site 1016998006046 conserved cis-peptide bond; other site 1016998006047 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1016998006048 DNA binding site [nucleotide binding] 1016998006049 active site 1016998006050 Int/Topo IB signature motif; other site 1016998006051 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 1016998006052 Clp amino terminal domain; Region: Clp_N; pfam02861 1016998006053 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1016998006054 Walker A motif; other site 1016998006055 ATP binding site [chemical binding]; other site 1016998006056 Walker B motif; other site 1016998006057 arginine finger; other site 1016998006058 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1016998006059 Walker A motif; other site 1016998006060 ATP binding site [chemical binding]; other site 1016998006061 Walker B motif; other site 1016998006062 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1016998006063 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1016998006064 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1016998006065 DNA-binding site [nucleotide binding]; DNA binding site 1016998006066 RNA-binding motif; other site 1016998006067 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1016998006068 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1016998006069 Walker A/P-loop; other site 1016998006070 ATP binding site [chemical binding]; other site 1016998006071 Q-loop/lid; other site 1016998006072 ABC transporter signature motif; other site 1016998006073 Walker B; other site 1016998006074 D-loop; other site 1016998006075 H-loop/switch region; other site 1016998006076 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1016998006077 FtsX-like permease family; Region: FtsX; pfam02687 1016998006078 macrolide transporter subunit MacA; Provisional; Region: PRK11578 1016998006079 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1016998006080 HlyD family secretion protein; Region: HlyD_3; pfam13437 1016998006081 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 1016998006082 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1016998006083 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 1016998006084 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1016998006085 putative active site [active] 1016998006086 putative metal-binding site [ion binding]; other site 1016998006087 Predicted membrane protein [Function unknown]; Region: COG2431 1016998006088 hybrid cluster protein; Provisional; Region: PRK05290 1016998006089 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1016998006090 ACS interaction site; other site 1016998006091 CODH interaction site; other site 1016998006092 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 1016998006093 hybrid metal cluster; other site 1016998006094 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 1016998006095 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1016998006096 FAD binding pocket [chemical binding]; other site 1016998006097 FAD binding motif [chemical binding]; other site 1016998006098 phosphate binding motif [ion binding]; other site 1016998006099 beta-alpha-beta structure motif; other site 1016998006100 NAD binding pocket [chemical binding]; other site 1016998006101 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1016998006102 catalytic loop [active] 1016998006103 iron binding site [ion binding]; other site 1016998006104 pyruvate dehydrogenase; Provisional; Region: PRK09124 1016998006105 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1016998006106 PYR/PP interface [polypeptide binding]; other site 1016998006107 dimer interface [polypeptide binding]; other site 1016998006108 tetramer interface [polypeptide binding]; other site 1016998006109 TPP binding site [chemical binding]; other site 1016998006110 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1016998006111 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1016998006112 TPP-binding site [chemical binding]; other site 1016998006113 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1016998006114 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1016998006115 tetramer interface [polypeptide binding]; other site 1016998006116 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998006117 catalytic residue [active] 1016998006118 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1016998006119 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 1016998006120 putative NAD(P) binding site [chemical binding]; other site 1016998006121 putative active site [active] 1016998006122 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1016998006123 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1016998006124 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1016998006125 NAD(P) binding site [chemical binding]; other site 1016998006126 active site 1016998006127 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1016998006128 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1016998006129 amidase catalytic site [active] 1016998006130 Zn binding residues [ion binding]; other site 1016998006131 substrate binding site [chemical binding]; other site 1016998006132 hypothetical protein; Provisional; Region: PRK02877 1016998006133 putative lipoprotein; Provisional; Region: PRK10533 1016998006134 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 1016998006135 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1016998006136 Walker A/P-loop; other site 1016998006137 ATP binding site [chemical binding]; other site 1016998006138 Q-loop/lid; other site 1016998006139 ABC transporter signature motif; other site 1016998006140 Walker B; other site 1016998006141 D-loop; other site 1016998006142 H-loop/switch region; other site 1016998006143 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1016998006144 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1016998006145 substrate binding pocket [chemical binding]; other site 1016998006146 membrane-bound complex binding site; other site 1016998006147 hinge residues; other site 1016998006148 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1016998006149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998006150 dimer interface [polypeptide binding]; other site 1016998006151 conserved gate region; other site 1016998006152 putative PBP binding loops; other site 1016998006153 ABC-ATPase subunit interface; other site 1016998006154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998006155 dimer interface [polypeptide binding]; other site 1016998006156 conserved gate region; other site 1016998006157 putative PBP binding loops; other site 1016998006158 ABC-ATPase subunit interface; other site 1016998006159 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1016998006160 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1016998006161 substrate binding pocket [chemical binding]; other site 1016998006162 membrane-bound complex binding site; other site 1016998006163 hinge residues; other site 1016998006164 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1016998006165 Sulfatase; Region: Sulfatase; cl17466 1016998006166 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1016998006167 active site 1016998006168 P-loop; other site 1016998006169 phosphorylation site [posttranslational modification] 1016998006170 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 1016998006171 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 1016998006172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1016998006173 S-adenosylmethionine binding site [chemical binding]; other site 1016998006174 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 1016998006175 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1016998006176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998006177 dimer interface [polypeptide binding]; other site 1016998006178 conserved gate region; other site 1016998006179 putative PBP binding loops; other site 1016998006180 ABC-ATPase subunit interface; other site 1016998006181 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998006182 dimer interface [polypeptide binding]; other site 1016998006183 conserved gate region; other site 1016998006184 putative PBP binding loops; other site 1016998006185 ABC-ATPase subunit interface; other site 1016998006186 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 1016998006187 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1016998006188 Walker A/P-loop; other site 1016998006189 ATP binding site [chemical binding]; other site 1016998006190 Q-loop/lid; other site 1016998006191 ABC transporter signature motif; other site 1016998006192 Walker B; other site 1016998006193 D-loop; other site 1016998006194 H-loop/switch region; other site 1016998006195 TOBE domain; Region: TOBE_2; pfam08402 1016998006196 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1016998006197 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1016998006198 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1016998006199 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1016998006200 RimK-like ATP-grasp domain; Region: RimK; pfam08443 1016998006201 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1016998006202 dimer interface [polypeptide binding]; other site 1016998006203 FMN binding site [chemical binding]; other site 1016998006204 NADPH bind site [chemical binding]; other site 1016998006205 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 1016998006206 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 1016998006207 GSH binding site [chemical binding]; other site 1016998006208 catalytic residues [active] 1016998006209 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 1016998006210 putative transporter; Provisional; Region: PRK04972 1016998006211 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1016998006212 TrkA-C domain; Region: TrkA_C; pfam02080 1016998006213 TrkA-C domain; Region: TrkA_C; pfam02080 1016998006214 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1016998006215 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1016998006216 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1016998006217 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1016998006218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998006219 putative substrate translocation pore; other site 1016998006220 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1016998006221 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1016998006222 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1016998006223 active site 1016998006224 motif I; other site 1016998006225 motif II; other site 1016998006226 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1016998006227 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 1016998006228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998006229 putative substrate translocation pore; other site 1016998006230 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1016998006231 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1016998006232 active site 1016998006233 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 1016998006234 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1016998006235 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1016998006236 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 1016998006237 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1016998006238 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1016998006239 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1016998006240 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1016998006241 putative C-terminal domain interface [polypeptide binding]; other site 1016998006242 putative GSH binding site (G-site) [chemical binding]; other site 1016998006243 putative dimer interface [polypeptide binding]; other site 1016998006244 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1016998006245 putative N-terminal domain interface [polypeptide binding]; other site 1016998006246 putative dimer interface [polypeptide binding]; other site 1016998006247 putative substrate binding pocket (H-site) [chemical binding]; other site 1016998006248 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1016998006249 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 1016998006250 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 1016998006251 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1016998006252 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1016998006253 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1016998006254 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1016998006255 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998006256 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 1016998006257 putative dimerization interface [polypeptide binding]; other site 1016998006258 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1016998006259 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1016998006260 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 1016998006261 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 1016998006262 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1016998006263 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1016998006264 active site 1016998006265 Uncharacterized conserved protein [Function unknown]; Region: COG3777 1016998006266 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1016998006267 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1016998006268 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1016998006269 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1016998006270 Ligand binding site [chemical binding]; other site 1016998006271 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1016998006272 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1016998006273 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 1016998006274 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1016998006275 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1016998006276 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1016998006277 FeS/SAM binding site; other site 1016998006278 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 1016998006279 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1016998006280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998006281 dimer interface [polypeptide binding]; other site 1016998006282 conserved gate region; other site 1016998006283 putative PBP binding loops; other site 1016998006284 ABC-ATPase subunit interface; other site 1016998006285 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 1016998006286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998006287 dimer interface [polypeptide binding]; other site 1016998006288 conserved gate region; other site 1016998006289 putative PBP binding loops; other site 1016998006290 ABC-ATPase subunit interface; other site 1016998006291 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 1016998006292 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 1016998006293 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1016998006294 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1016998006295 Walker A/P-loop; other site 1016998006296 ATP binding site [chemical binding]; other site 1016998006297 Q-loop/lid; other site 1016998006298 ABC transporter signature motif; other site 1016998006299 Walker B; other site 1016998006300 D-loop; other site 1016998006301 H-loop/switch region; other site 1016998006302 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1016998006303 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1016998006304 Walker A/P-loop; other site 1016998006305 ATP binding site [chemical binding]; other site 1016998006306 Q-loop/lid; other site 1016998006307 ABC transporter signature motif; other site 1016998006308 Walker B; other site 1016998006309 D-loop; other site 1016998006310 H-loop/switch region; other site 1016998006311 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1016998006312 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 1016998006313 catalytic nucleophile [active] 1016998006314 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 1016998006315 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1016998006316 dimer interface [polypeptide binding]; other site 1016998006317 putative functional site; other site 1016998006318 putative MPT binding site; other site 1016998006319 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1016998006320 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1016998006321 ATP binding site [chemical binding]; other site 1016998006322 substrate interface [chemical binding]; other site 1016998006323 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 1016998006324 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1016998006325 FeS/SAM binding site; other site 1016998006326 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 1016998006327 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1016998006328 dimer interface [polypeptide binding]; other site 1016998006329 active site 1016998006330 glycine loop; other site 1016998006331 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1016998006332 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1016998006333 active site 1016998006334 motif I; other site 1016998006335 motif II; other site 1016998006336 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1016998006337 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 1016998006338 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1016998006339 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1016998006340 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1016998006341 Walker A/P-loop; other site 1016998006342 ATP binding site [chemical binding]; other site 1016998006343 ABC transporter signature motif; other site 1016998006344 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1016998006345 Walker B; other site 1016998006346 ABC transporter; Region: ABC_tran_2; pfam12848 1016998006347 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1016998006348 L,D-transpeptidase; Provisional; Region: PRK10260 1016998006349 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1016998006350 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 1016998006351 transmembrane helices; other site 1016998006352 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1016998006353 manganese transport regulator MntR; Provisional; Region: PRK11050 1016998006354 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1016998006355 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1016998006356 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1016998006357 Sulfatase; Region: Sulfatase; pfam00884 1016998006358 outer membrane protein X; Provisional; Region: ompX; PRK09408 1016998006359 threonine and homoserine efflux system; Provisional; Region: PRK10532 1016998006360 EamA-like transporter family; Region: EamA; pfam00892 1016998006361 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1016998006362 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1016998006363 dimerization interface [polypeptide binding]; other site 1016998006364 DPS ferroxidase diiron center [ion binding]; other site 1016998006365 ion pore; other site 1016998006366 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 1016998006367 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1016998006368 substrate binding pocket [chemical binding]; other site 1016998006369 membrane-bound complex binding site; other site 1016998006370 hinge residues; other site 1016998006371 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1016998006372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998006373 dimer interface [polypeptide binding]; other site 1016998006374 conserved gate region; other site 1016998006375 putative PBP binding loops; other site 1016998006376 ABC-ATPase subunit interface; other site 1016998006377 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 1016998006378 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1016998006379 Walker A/P-loop; other site 1016998006380 ATP binding site [chemical binding]; other site 1016998006381 Q-loop/lid; other site 1016998006382 ABC transporter signature motif; other site 1016998006383 Walker B; other site 1016998006384 D-loop; other site 1016998006385 H-loop/switch region; other site 1016998006386 putative mechanosensitive channel protein; Provisional; Region: PRK11465 1016998006387 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1016998006388 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 1016998006389 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 1016998006390 hypothetical protein; Provisional; Region: PRK11019 1016998006391 hypothetical protein; Provisional; Region: PRK10259 1016998006392 glycosyl transferase family protein; Provisional; Region: PRK08136 1016998006393 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1016998006394 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 1016998006395 DEAD_2; Region: DEAD_2; pfam06733 1016998006396 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1016998006397 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1016998006398 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1016998006399 ATP binding site [chemical binding]; other site 1016998006400 Mg++ binding site [ion binding]; other site 1016998006401 motif III; other site 1016998006402 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1016998006403 nucleotide binding region [chemical binding]; other site 1016998006404 ATP-binding site [chemical binding]; other site 1016998006405 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1016998006406 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1016998006407 putative catalytic cysteine [active] 1016998006408 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1016998006409 putative active site [active] 1016998006410 metal binding site [ion binding]; metal-binding site 1016998006411 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1016998006412 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1016998006413 PYR/PP interface [polypeptide binding]; other site 1016998006414 dimer interface [polypeptide binding]; other site 1016998006415 TPP binding site [chemical binding]; other site 1016998006416 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1016998006417 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1016998006418 TPP-binding site [chemical binding]; other site 1016998006419 dimer interface [polypeptide binding]; other site 1016998006420 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1016998006421 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1016998006422 NAD(P) binding site [chemical binding]; other site 1016998006423 active site 1016998006424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998006425 D-galactonate transporter; Region: 2A0114; TIGR00893 1016998006426 putative substrate translocation pore; other site 1016998006427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998006428 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1016998006429 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998006430 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1016998006431 dimerization interface [polypeptide binding]; other site 1016998006432 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 1016998006433 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1016998006434 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1016998006435 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1016998006436 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1016998006437 HlyD family secretion protein; Region: HlyD_3; pfam13437 1016998006438 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1016998006439 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1016998006440 Walker A/P-loop; other site 1016998006441 ATP binding site [chemical binding]; other site 1016998006442 Q-loop/lid; other site 1016998006443 ABC transporter signature motif; other site 1016998006444 Walker B; other site 1016998006445 D-loop; other site 1016998006446 H-loop/switch region; other site 1016998006447 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1016998006448 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1016998006449 Walker A/P-loop; other site 1016998006450 ATP binding site [chemical binding]; other site 1016998006451 Q-loop/lid; other site 1016998006452 ABC transporter signature motif; other site 1016998006453 Walker B; other site 1016998006454 D-loop; other site 1016998006455 H-loop/switch region; other site 1016998006456 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1016998006457 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1016998006458 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1016998006459 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1016998006460 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 1016998006461 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 1016998006462 putative catalytic site [active] 1016998006463 putative metal binding site [ion binding]; other site 1016998006464 putative phosphate binding site [ion binding]; other site 1016998006465 cardiolipin synthase 2; Provisional; Region: PRK11263 1016998006466 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1016998006467 putative active site [active] 1016998006468 catalytic site [active] 1016998006469 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1016998006470 putative active site [active] 1016998006471 catalytic site [active] 1016998006472 Predicted integral membrane protein [Function unknown]; Region: COG0392 1016998006473 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1016998006474 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 1016998006475 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1016998006476 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1016998006477 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1016998006478 MoaE homodimer interface [polypeptide binding]; other site 1016998006479 MoaD interaction [polypeptide binding]; other site 1016998006480 active site residues [active] 1016998006481 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1016998006482 MoaE interaction surface [polypeptide binding]; other site 1016998006483 MoeB interaction surface [polypeptide binding]; other site 1016998006484 thiocarboxylated glycine; other site 1016998006485 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1016998006486 trimer interface [polypeptide binding]; other site 1016998006487 dimer interface [polypeptide binding]; other site 1016998006488 putative active site [active] 1016998006489 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1016998006490 MPT binding site; other site 1016998006491 trimer interface [polypeptide binding]; other site 1016998006492 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1016998006493 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1016998006494 FeS/SAM binding site; other site 1016998006495 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1016998006496 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1016998006497 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1016998006498 putative substrate binding pocket [chemical binding]; other site 1016998006499 dimer interface [polypeptide binding]; other site 1016998006500 phosphate binding site [ion binding]; other site 1016998006501 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 1016998006502 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 1016998006503 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 1016998006504 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1016998006505 Leucine-rich repeats; other site 1016998006506 Substrate binding site [chemical binding]; other site 1016998006507 excinuclease ABC subunit B; Provisional; Region: PRK05298 1016998006508 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1016998006509 ATP binding site [chemical binding]; other site 1016998006510 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1016998006511 nucleotide binding region [chemical binding]; other site 1016998006512 ATP-binding site [chemical binding]; other site 1016998006513 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1016998006514 UvrB/uvrC motif; Region: UVR; pfam02151 1016998006515 AAA domain; Region: AAA_26; pfam13500 1016998006516 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1016998006517 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1016998006518 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1016998006519 S-adenosylmethionine binding site [chemical binding]; other site 1016998006520 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1016998006521 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1016998006522 substrate-cofactor binding pocket; other site 1016998006523 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998006524 catalytic residue [active] 1016998006525 biotin synthase; Provisional; Region: PRK15108 1016998006526 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1016998006527 FeS/SAM binding site; other site 1016998006528 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1016998006529 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 1016998006530 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1016998006531 inhibitor-cofactor binding pocket; inhibition site 1016998006532 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998006533 catalytic residue [active] 1016998006534 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1016998006535 substrate binding site [chemical binding]; other site 1016998006536 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1016998006537 active sites [active] 1016998006538 tetramer interface [polypeptide binding]; other site 1016998006539 urocanate hydratase; Provisional; Region: PRK05414 1016998006540 histidine utilization repressor; Provisional; Region: PRK14999 1016998006541 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1016998006542 DNA-binding site [nucleotide binding]; DNA binding site 1016998006543 UTRA domain; Region: UTRA; pfam07702 1016998006544 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 1016998006545 putative active site [active] 1016998006546 putative metal binding site [ion binding]; other site 1016998006547 imidazolonepropionase; Validated; Region: PRK09356 1016998006548 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1016998006549 active site 1016998006550 acyl-CoA thioesterase; Provisional; Region: PRK10531 1016998006551 putative pectinesterase; Region: PLN02432; cl01911 1016998006552 6-phosphogluconolactonase; Provisional; Region: PRK11028 1016998006553 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 1016998006554 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1016998006555 active site 1016998006556 motif I; other site 1016998006557 motif II; other site 1016998006558 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1016998006559 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 1016998006560 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1016998006561 Walker A/P-loop; other site 1016998006562 ATP binding site [chemical binding]; other site 1016998006563 Q-loop/lid; other site 1016998006564 ABC transporter signature motif; other site 1016998006565 Walker B; other site 1016998006566 D-loop; other site 1016998006567 H-loop/switch region; other site 1016998006568 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1016998006569 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1016998006570 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998006571 dimer interface [polypeptide binding]; other site 1016998006572 conserved gate region; other site 1016998006573 putative PBP binding loops; other site 1016998006574 ABC-ATPase subunit interface; other site 1016998006575 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 1016998006576 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1016998006577 substrate binding pocket [chemical binding]; other site 1016998006578 membrane-bound complex binding site; other site 1016998006579 hinge residues; other site 1016998006580 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 1016998006581 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 1016998006582 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1016998006583 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1016998006584 TOBE domain; Region: TOBE; pfam03459 1016998006585 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 1016998006586 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1016998006587 Walker A/P-loop; other site 1016998006588 ATP binding site [chemical binding]; other site 1016998006589 Q-loop/lid; other site 1016998006590 ABC transporter signature motif; other site 1016998006591 Walker B; other site 1016998006592 D-loop; other site 1016998006593 H-loop/switch region; other site 1016998006594 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1016998006595 Walker A/P-loop; other site 1016998006596 ATP binding site [chemical binding]; other site 1016998006597 Q-loop/lid; other site 1016998006598 ABC transporter signature motif; other site 1016998006599 Walker B; other site 1016998006600 D-loop; other site 1016998006601 H-loop/switch region; other site 1016998006602 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4714 1016998006603 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 1016998006604 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1016998006605 NAD binding site [chemical binding]; other site 1016998006606 homodimer interface [polypeptide binding]; other site 1016998006607 active site 1016998006608 substrate binding site [chemical binding]; other site 1016998006609 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 1016998006610 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1016998006611 dimer interface [polypeptide binding]; other site 1016998006612 active site 1016998006613 galactokinase; Provisional; Region: PRK05101 1016998006614 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1016998006615 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1016998006616 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1016998006617 active site 1016998006618 catalytic residues [active] 1016998006619 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1016998006620 catalytic core [active] 1016998006621 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1016998006622 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1016998006623 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1016998006624 Walker A/P-loop; other site 1016998006625 ATP binding site [chemical binding]; other site 1016998006626 Q-loop/lid; other site 1016998006627 ABC transporter signature motif; other site 1016998006628 Walker B; other site 1016998006629 D-loop; other site 1016998006630 H-loop/switch region; other site 1016998006631 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1016998006632 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1016998006633 dimer interface [polypeptide binding]; other site 1016998006634 putative PBP binding regions; other site 1016998006635 ABC-ATPase subunit interface; other site 1016998006636 Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767 1016998006637 oxaloacetate decarboxylase; Provisional; Region: PRK14040 1016998006638 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1016998006639 active site 1016998006640 catalytic residues [active] 1016998006641 metal binding site [ion binding]; metal-binding site 1016998006642 homodimer binding site [polypeptide binding]; other site 1016998006643 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1016998006644 carboxyltransferase (CT) interaction site; other site 1016998006645 biotinylation site [posttranslational modification]; other site 1016998006646 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 1016998006647 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1016998006648 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1016998006649 transmembrane helices; other site 1016998006650 cell density-dependent motility repressor; Provisional; Region: PRK10082 1016998006651 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998006652 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1016998006653 dimerization interface [polypeptide binding]; other site 1016998006654 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1016998006655 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998006656 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1016998006657 dimerization interface [polypeptide binding]; other site 1016998006658 fumarate hydratase; Provisional; Region: PRK06246 1016998006659 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Region: FumA; COG1838 1016998006660 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1016998006661 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1016998006662 YbgS-like protein; Region: YbgS; pfam13985 1016998006663 zinc transporter ZitB; Provisional; Region: PRK03557 1016998006664 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 1016998006665 quinolinate synthetase; Provisional; Region: PRK09375 1016998006666 tol-pal system protein YbgF; Provisional; Region: PRK10803 1016998006667 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1016998006668 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1016998006669 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 1016998006670 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1016998006671 ligand binding site [chemical binding]; other site 1016998006672 translocation protein TolB; Provisional; Region: tolB; PRK03629 1016998006673 TolB amino-terminal domain; Region: TolB_N; pfam04052 1016998006674 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1016998006675 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1016998006676 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1016998006677 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 1016998006678 TolA C-terminal; Region: TolA; pfam06519 1016998006679 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1016998006680 colicin uptake protein TolR; Provisional; Region: PRK11024 1016998006681 colicin uptake protein TolQ; Provisional; Region: PRK10801 1016998006682 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1016998006683 active site 1016998006684 hypothetical protein; Provisional; Region: PRK10588 1016998006685 Predicted outer membrane lipoprotein [Function unknown]; Region: COG4890 1016998006686 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 1016998006687 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1016998006688 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1016998006689 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1016998006690 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1016998006691 CoA binding domain; Region: CoA_binding; smart00881 1016998006692 CoA-ligase; Region: Ligase_CoA; pfam00549 1016998006693 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1016998006694 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1016998006695 CoA-ligase; Region: Ligase_CoA; pfam00549 1016998006696 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1016998006697 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1016998006698 E3 interaction surface; other site 1016998006699 lipoyl attachment site [posttranslational modification]; other site 1016998006700 e3 binding domain; Region: E3_binding; pfam02817 1016998006701 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1016998006702 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1016998006703 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1016998006704 TPP-binding site [chemical binding]; other site 1016998006705 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1016998006706 dimer interface [polypeptide binding]; other site 1016998006707 PYR/PP interface [polypeptide binding]; other site 1016998006708 TPP binding site [chemical binding]; other site 1016998006709 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1016998006710 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1016998006711 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 1016998006712 L-aspartate oxidase; Provisional; Region: PRK06175 1016998006713 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1016998006714 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1016998006715 SdhC subunit interface [polypeptide binding]; other site 1016998006716 proximal heme binding site [chemical binding]; other site 1016998006717 cardiolipin binding site; other site 1016998006718 Iron-sulfur protein interface; other site 1016998006719 proximal quinone binding site [chemical binding]; other site 1016998006720 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1016998006721 Iron-sulfur protein interface; other site 1016998006722 proximal quinone binding site [chemical binding]; other site 1016998006723 SdhD (CybS) interface [polypeptide binding]; other site 1016998006724 proximal heme binding site [chemical binding]; other site 1016998006725 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1016998006726 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1016998006727 dimer interface [polypeptide binding]; other site 1016998006728 active site 1016998006729 citrylCoA binding site [chemical binding]; other site 1016998006730 NADH binding [chemical binding]; other site 1016998006731 cationic pore residues; other site 1016998006732 oxalacetate/citrate binding site [chemical binding]; other site 1016998006733 coenzyme A binding site [chemical binding]; other site 1016998006734 catalytic triad [active] 1016998006735 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 1016998006736 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1016998006737 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1016998006738 endonuclease VIII; Provisional; Region: PRK10445 1016998006739 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 1016998006740 DNA binding site [nucleotide binding] 1016998006741 catalytic residue [active] 1016998006742 putative catalytic residues [active] 1016998006743 H2TH interface [polypeptide binding]; other site 1016998006744 intercalation triad [nucleotide binding]; other site 1016998006745 substrate specificity determining residue; other site 1016998006746 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1016998006747 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1016998006748 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1016998006749 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 1016998006750 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1016998006751 active site 1016998006752 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1016998006753 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1016998006754 active site 1016998006755 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1016998006756 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1016998006757 Walker A/P-loop; other site 1016998006758 ATP binding site [chemical binding]; other site 1016998006759 Q-loop/lid; other site 1016998006760 ABC transporter signature motif; other site 1016998006761 Walker B; other site 1016998006762 D-loop; other site 1016998006763 H-loop/switch region; other site 1016998006764 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1016998006765 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1016998006766 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1016998006767 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1016998006768 putative ADP-binding pocket [chemical binding]; other site 1016998006769 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1016998006770 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1016998006771 active site 1016998006772 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1016998006773 UDP-galactopyranose mutase; Region: GLF; pfam03275 1016998006774 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1016998006775 active site 1016998006776 DNA binding site [nucleotide binding] 1016998006777 Int/Topo IB signature motif; other site 1016998006778 LamB/YcsF family protein; Provisional; Region: PRK05406 1016998006779 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1016998006780 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1016998006781 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1016998006782 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1016998006783 metal-binding protein; Provisional; Region: PRK10799 1016998006784 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1016998006785 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998006786 putative substrate translocation pore; other site 1016998006787 POT family; Region: PTR2; pfam00854 1016998006788 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 1016998006789 DNA photolyase; Region: DNA_photolyase; pfam00875 1016998006790 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1016998006791 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 1016998006792 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1016998006793 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1016998006794 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1016998006795 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1016998006796 sensor protein KdpD; Provisional; Region: PRK10490 1016998006797 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1016998006798 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1016998006799 Ligand Binding Site [chemical binding]; other site 1016998006800 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1016998006801 GAF domain; Region: GAF_3; pfam13492 1016998006802 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1016998006803 dimer interface [polypeptide binding]; other site 1016998006804 phosphorylation site [posttranslational modification] 1016998006805 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1016998006806 ATP binding site [chemical binding]; other site 1016998006807 Mg2+ binding site [ion binding]; other site 1016998006808 G-X-G motif; other site 1016998006809 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1016998006810 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1016998006811 active site 1016998006812 phosphorylation site [posttranslational modification] 1016998006813 intermolecular recognition site; other site 1016998006814 dimerization interface [polypeptide binding]; other site 1016998006815 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1016998006816 DNA binding site [nucleotide binding] 1016998006817 ornithine decarboxylase; Provisional; Region: PRK13578 1016998006818 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1016998006819 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1016998006820 homodimer interface [polypeptide binding]; other site 1016998006821 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998006822 catalytic residue [active] 1016998006823 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1016998006824 putrescine transporter; Provisional; Region: potE; PRK10655 1016998006825 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 1016998006826 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 1016998006827 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1016998006828 active site 1016998006829 substrate binding site [chemical binding]; other site 1016998006830 metal binding site [ion binding]; metal-binding site 1016998006831 replication initiation regulator SeqA; Provisional; Region: PRK11187 1016998006832 acyl-CoA esterase; Provisional; Region: PRK10673 1016998006833 PGAP1-like protein; Region: PGAP1; pfam07819 1016998006834 LexA regulated protein; Provisional; Region: PRK11675 1016998006835 flavodoxin FldA; Validated; Region: PRK09267 1016998006836 ferric uptake regulator; Provisional; Region: fur; PRK09462 1016998006837 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1016998006838 metal binding site 2 [ion binding]; metal-binding site 1016998006839 putative DNA binding helix; other site 1016998006840 metal binding site 1 [ion binding]; metal-binding site 1016998006841 dimer interface [polypeptide binding]; other site 1016998006842 structural Zn2+ binding site [ion binding]; other site 1016998006843 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1016998006844 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998006845 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1016998006846 putative dimerization interface [polypeptide binding]; other site 1016998006847 tricarballylate dehydrogenase; Validated; Region: PRK08274 1016998006848 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1016998006849 tricarballylate utilization protein B; Provisional; Region: PRK15033 1016998006850 citrate-proton symporter; Provisional; Region: PRK15075 1016998006851 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998006852 putative substrate translocation pore; other site 1016998006853 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1016998006854 YbfN-like lipoprotein; Region: YbfN; pfam13982 1016998006855 outer membrane porin, OprD family; Region: OprD; pfam03573 1016998006856 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1016998006857 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1016998006858 active site 1016998006859 HIGH motif; other site 1016998006860 nucleotide binding site [chemical binding]; other site 1016998006861 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1016998006862 KMSKS motif; other site 1016998006863 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1016998006864 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 1016998006865 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1016998006866 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1016998006867 active site turn [active] 1016998006868 phosphorylation site [posttranslational modification] 1016998006869 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1016998006870 HPr interaction site; other site 1016998006871 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1016998006872 active site 1016998006873 phosphorylation site [posttranslational modification] 1016998006874 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1016998006875 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1016998006876 active site 1016998006877 trimer interface [polypeptide binding]; other site 1016998006878 allosteric site; other site 1016998006879 active site lid [active] 1016998006880 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1016998006881 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1016998006882 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1016998006883 active site 1016998006884 dimer interface [polypeptide binding]; other site 1016998006885 MarR family; Region: MarR; pfam01047 1016998006886 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1016998006887 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1016998006888 nucleotide binding site [chemical binding]; other site 1016998006889 UMP phosphatase; Provisional; Region: PRK10444 1016998006890 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1016998006891 active site 1016998006892 motif I; other site 1016998006893 motif II; other site 1016998006894 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1016998006895 asparagine synthetase B; Provisional; Region: asnB; PRK09431 1016998006896 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1016998006897 active site 1016998006898 dimer interface [polypeptide binding]; other site 1016998006899 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1016998006900 Ligand Binding Site [chemical binding]; other site 1016998006901 Molecular Tunnel; other site 1016998006902 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 1016998006903 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1016998006904 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1016998006905 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1016998006906 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1016998006907 FeS/SAM binding site; other site 1016998006908 TRAM domain; Region: TRAM; pfam01938 1016998006909 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1016998006910 PhoH-like protein; Region: PhoH; pfam02562 1016998006911 metal-binding heat shock protein; Provisional; Region: PRK00016 1016998006912 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 1016998006913 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1016998006914 Transporter associated domain; Region: CorC_HlyC; smart01091 1016998006915 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1016998006916 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1016998006917 putative active site [active] 1016998006918 catalytic triad [active] 1016998006919 putative dimer interface [polypeptide binding]; other site 1016998006920 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 1016998006921 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1016998006922 substrate binding pocket [chemical binding]; other site 1016998006923 membrane-bound complex binding site; other site 1016998006924 hinge residues; other site 1016998006925 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1016998006926 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998006927 dimer interface [polypeptide binding]; other site 1016998006928 conserved gate region; other site 1016998006929 putative PBP binding loops; other site 1016998006930 ABC-ATPase subunit interface; other site 1016998006931 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1016998006932 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998006933 dimer interface [polypeptide binding]; other site 1016998006934 conserved gate region; other site 1016998006935 putative PBP binding loops; other site 1016998006936 ABC-ATPase subunit interface; other site 1016998006937 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1016998006938 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1016998006939 Walker A/P-loop; other site 1016998006940 ATP binding site [chemical binding]; other site 1016998006941 Q-loop/lid; other site 1016998006942 ABC transporter signature motif; other site 1016998006943 Walker B; other site 1016998006944 D-loop; other site 1016998006945 H-loop/switch region; other site 1016998006946 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1016998006947 active site 1016998006948 tetramer interface [polypeptide binding]; other site 1016998006949 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1016998006950 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 1016998006951 nucleotide binding site [chemical binding]; other site 1016998006952 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1016998006953 SBD interface [polypeptide binding]; other site 1016998006954 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 1016998006955 HSP70 interaction site [polypeptide binding]; other site 1016998006956 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 1016998006957 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 1016998006958 HSP70 interaction site [polypeptide binding]; other site 1016998006959 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 1016998006960 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1016998006961 Sel1-like repeats; Region: SEL1; smart00671 1016998006962 Sel1-like repeats; Region: SEL1; smart00671 1016998006963 Sel1-like repeats; Region: SEL1; smart00671 1016998006964 Sel1-like repeats; Region: SEL1; smart00671 1016998006965 Sel1-like repeats; Region: SEL1; smart00671 1016998006966 hypothetical protein; Provisional; Region: PRK11032 1016998006967 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1016998006968 Propionate catabolism activator; Region: PrpR_N; pfam06506 1016998006969 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1016998006970 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1016998006971 Walker A motif; other site 1016998006972 ATP binding site [chemical binding]; other site 1016998006973 Walker B motif; other site 1016998006974 arginine finger; other site 1016998006975 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 1016998006976 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1016998006977 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1016998006978 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1016998006979 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1016998006980 HIGH motif; other site 1016998006981 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1016998006982 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1016998006983 active site 1016998006984 KMSKS motif; other site 1016998006985 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1016998006986 tRNA binding surface [nucleotide binding]; other site 1016998006987 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 1016998006988 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1016998006989 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1016998006990 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1016998006991 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1016998006992 active site 1016998006993 (T/H)XGH motif; other site 1016998006994 threonine-phosphate decarboxylase; Provisional; Region: PRK08056 1016998006995 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1016998006996 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998006997 homodimer interface [polypeptide binding]; other site 1016998006998 catalytic residue [active] 1016998006999 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1016998007000 catalytic core [active] 1016998007001 ribosome-associated protein; Provisional; Region: PRK11538 1016998007002 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 1016998007003 penicillin-binding protein 2; Provisional; Region: PRK10795 1016998007004 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1016998007005 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1016998007006 cell wall shape-determining protein; Provisional; Region: PRK10794 1016998007007 rare lipoprotein A; Provisional; Region: PRK10672 1016998007008 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1016998007009 Sporulation related domain; Region: SPOR; pfam05036 1016998007010 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 1016998007011 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1016998007012 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1016998007013 hypothetical protein; Provisional; Region: PRK04998 1016998007014 lipoate-protein ligase B; Provisional; Region: PRK14342 1016998007015 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 1016998007016 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998007017 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1016998007018 substrate binding pocket [chemical binding]; other site 1016998007019 dimerization interface [polypeptide binding]; other site 1016998007020 lipoyl synthase; Provisional; Region: PRK05481 1016998007021 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1016998007022 FeS/SAM binding site; other site 1016998007023 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 1016998007024 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1016998007025 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1016998007026 putative active site [active] 1016998007027 catalytic triad [active] 1016998007028 putative dimer interface [polypeptide binding]; other site 1016998007029 chromosome condensation membrane protein; Provisional; Region: PRK14196 1016998007030 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1016998007031 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1016998007032 DNA-binding site [nucleotide binding]; DNA binding site 1016998007033 RNA-binding motif; other site 1016998007034 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 1016998007035 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 1016998007036 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1016998007037 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 1016998007038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1016998007039 active site 1016998007040 phosphorylation site [posttranslational modification] 1016998007041 intermolecular recognition site; other site 1016998007042 dimerization interface [polypeptide binding]; other site 1016998007043 Transcriptional regulator; Region: CitT; pfam12431 1016998007044 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 1016998007045 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1016998007046 putative active site [active] 1016998007047 heme pocket [chemical binding]; other site 1016998007048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1016998007049 ATP binding site [chemical binding]; other site 1016998007050 Mg2+ binding site [ion binding]; other site 1016998007051 G-X-G motif; other site 1016998007052 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 1016998007053 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 1016998007054 putative active site [active] 1016998007055 (T/H)XGH motif; other site 1016998007056 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 1016998007057 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1016998007058 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 1016998007059 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1016998007060 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 1016998007061 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 1016998007062 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1016998007063 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1016998007064 transmembrane helices; other site 1016998007065 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 1016998007066 B1 nucleotide binding pocket [chemical binding]; other site 1016998007067 B2 nucleotide binding pocket [chemical binding]; other site 1016998007068 CAS motifs; other site 1016998007069 active site 1016998007070 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1016998007071 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1016998007072 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1016998007073 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1016998007074 NAD binding site [chemical binding]; other site 1016998007075 catalytic Zn binding site [ion binding]; other site 1016998007076 structural Zn binding site [ion binding]; other site 1016998007077 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1016998007078 Ligand Binding Site [chemical binding]; other site 1016998007079 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 1016998007080 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 1016998007081 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1016998007082 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1016998007083 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1016998007084 putative molybdopterin cofactor binding site [chemical binding]; other site 1016998007085 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 1016998007086 molybdopterin cofactor binding site; other site 1016998007087 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 1016998007088 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1016998007089 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1016998007090 catalytic residue [active] 1016998007091 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1016998007092 catalytic residues [active] 1016998007093 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1016998007094 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1016998007095 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 1016998007096 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1016998007097 dimer interface [polypeptide binding]; other site 1016998007098 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1016998007099 catalytic triad [active] 1016998007100 peroxidatic and resolving cysteines [active] 1016998007101 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 1016998007102 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1016998007103 dimerization domain [polypeptide binding]; other site 1016998007104 dimer interface [polypeptide binding]; other site 1016998007105 catalytic residues [active] 1016998007106 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 1016998007107 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998007108 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1016998007109 dimerization interface [polypeptide binding]; other site 1016998007110 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 1016998007111 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1016998007112 Active Sites [active] 1016998007113 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 1016998007114 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1016998007115 ParB-like nuclease domain; Region: ParBc; pfam02195 1016998007116 methionine aminotransferase; Validated; Region: PRK09082 1016998007117 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1016998007118 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998007119 homodimer interface [polypeptide binding]; other site 1016998007120 catalytic residue [active] 1016998007121 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1016998007122 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 1016998007123 putative active site [active] 1016998007124 metal binding site [ion binding]; metal-binding site 1016998007125 Uncharacterized small protein [Function unknown]; Region: COG2879 1016998007126 carbon starvation protein A; Provisional; Region: PRK15015 1016998007127 Carbon starvation protein CstA; Region: CstA; pfam02554 1016998007128 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1016998007129 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1016998007130 CoenzymeA binding site [chemical binding]; other site 1016998007131 subunit interaction site [polypeptide binding]; other site 1016998007132 PHB binding site; other site 1016998007133 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1016998007134 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 1016998007135 putative NAD(P) binding site [chemical binding]; other site 1016998007136 active site 1016998007137 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1016998007138 hydrophobic substrate binding pocket; other site 1016998007139 Isochorismatase family; Region: Isochorismatase; pfam00857 1016998007140 active site 1016998007141 conserved cis-peptide bond; other site 1016998007142 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1016998007143 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 1016998007144 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1016998007145 acyl-activating enzyme (AAE) consensus motif; other site 1016998007146 active site 1016998007147 AMP binding site [chemical binding]; other site 1016998007148 substrate binding site [chemical binding]; other site 1016998007149 isochorismate synthase EntC; Provisional; Region: PRK15016 1016998007150 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1016998007151 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 1016998007152 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1016998007153 siderophore binding site; other site 1016998007154 enterobactin exporter EntS; Provisional; Region: PRK10489 1016998007155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998007156 putative substrate translocation pore; other site 1016998007157 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1016998007158 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1016998007159 ABC-ATPase subunit interface; other site 1016998007160 dimer interface [polypeptide binding]; other site 1016998007161 putative PBP binding regions; other site 1016998007162 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1016998007163 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1016998007164 ABC-ATPase subunit interface; other site 1016998007165 dimer interface [polypeptide binding]; other site 1016998007166 putative PBP binding regions; other site 1016998007167 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 1016998007168 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1016998007169 Walker A/P-loop; other site 1016998007170 ATP binding site [chemical binding]; other site 1016998007171 Q-loop/lid; other site 1016998007172 ABC transporter signature motif; other site 1016998007173 Walker B; other site 1016998007174 D-loop; other site 1016998007175 H-loop/switch region; other site 1016998007176 LPS O-antigen length regulator; Provisional; Region: PRK10381 1016998007177 Chain length determinant protein; Region: Wzz; pfam02706 1016998007178 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1016998007179 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1016998007180 acyl-activating enzyme (AAE) consensus motif; other site 1016998007181 AMP binding site [chemical binding]; other site 1016998007182 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1016998007183 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1016998007184 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 1016998007185 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1016998007186 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1016998007187 outer membrane receptor FepA; Provisional; Region: PRK13524 1016998007188 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1016998007189 N-terminal plug; other site 1016998007190 ligand-binding site [chemical binding]; other site 1016998007191 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 1016998007192 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1016998007193 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 1016998007194 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1016998007195 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 1016998007196 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1016998007197 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1016998007198 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1016998007199 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1016998007200 hypothetical protein; Provisional; Region: PRK10250 1016998007201 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1016998007202 dimer interface [polypeptide binding]; other site 1016998007203 FMN binding site [chemical binding]; other site 1016998007204 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 1016998007205 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1016998007206 active site 1016998007207 oxyanion hole [active] 1016998007208 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1016998007209 catalytic triad [active] 1016998007210 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 1016998007211 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1016998007212 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1016998007213 phenylalanine transporter; Provisional; Region: PRK10249 1016998007214 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 1016998007215 Predicted membrane protein [Function unknown]; Region: COG3059 1016998007216 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1016998007217 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 1016998007218 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1016998007219 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1016998007220 Cupin; Region: Cupin_6; pfam12852 1016998007221 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1016998007222 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1016998007223 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1016998007224 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1016998007225 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1016998007226 ATP binding site [chemical binding]; other site 1016998007227 G-X-G motif; other site 1016998007228 Predicted membrane protein [Function unknown]; Region: COG2246 1016998007229 GtrA-like protein; Region: GtrA; pfam04138 1016998007230 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1016998007231 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1016998007232 Ligand binding site; other site 1016998007233 Putative Catalytic site; other site 1016998007234 DXD motif; other site 1016998007235 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1016998007236 Transposase; Region: HTH_Tnp_1; cl17663 1016998007237 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1016998007238 fimbriae regulatory protein FimW; Provisional; Region: PRK15201 1016998007239 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1016998007240 DNA binding residues [nucleotide binding] 1016998007241 dimerization interface [polypeptide binding]; other site 1016998007242 transcriptional regulator FimZ; Provisional; Region: PRK09935 1016998007243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1016998007244 active site 1016998007245 phosphorylation site [posttranslational modification] 1016998007246 intermolecular recognition site; other site 1016998007247 dimerization interface [polypeptide binding]; other site 1016998007248 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1016998007249 DNA binding residues [nucleotide binding] 1016998007250 dimerization interface [polypeptide binding]; other site 1016998007251 fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934 1016998007252 fimbrial-like adhesin; Provisional; Region: fimH; PRK15199 1016998007253 outer membrane usher protein FimD; Provisional; Region: PRK15198 1016998007254 PapC N-terminal domain; Region: PapC_N; pfam13954 1016998007255 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1016998007256 PapC C-terminal domain; Region: PapC_C; pfam13953 1016998007257 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 1016998007258 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1016998007259 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1016998007260 fimbrial protein FimI; Provisional; Region: PRK15200 1016998007261 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 1016998007262 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 1016998007263 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1016998007264 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1016998007265 homodimer interface [polypeptide binding]; other site 1016998007266 NADP binding site [chemical binding]; other site 1016998007267 substrate binding site [chemical binding]; other site 1016998007268 ribosome-associated protein; Provisional; Region: PRK11507 1016998007269 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1016998007270 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4727 1016998007271 Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916 1016998007272 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1016998007273 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1016998007274 active site 1016998007275 HIGH motif; other site 1016998007276 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1016998007277 KMSKS motif; other site 1016998007278 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1016998007279 tRNA binding surface [nucleotide binding]; other site 1016998007280 anticodon binding site; other site 1016998007281 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1016998007282 substrate binding site [chemical binding]; other site 1016998007283 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1016998007284 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1016998007285 putative active site [active] 1016998007286 putative metal binding site [ion binding]; other site 1016998007287 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1016998007288 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1016998007289 ATP-grasp domain; Region: ATP-grasp; pfam02222 1016998007290 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1016998007291 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1016998007292 putative substrate binding site [chemical binding]; other site 1016998007293 nucleotide binding site [chemical binding]; other site 1016998007294 nucleotide binding site [chemical binding]; other site 1016998007295 homodimer interface [polypeptide binding]; other site 1016998007296 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 1016998007297 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 1016998007298 membrane protein FdrA; Validated; Region: PRK06091 1016998007299 CoA binding domain; Region: CoA_binding; pfam02629 1016998007300 CoA-ligase; Region: Ligase_CoA; pfam00549 1016998007301 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 1016998007302 allantoate amidohydrolase; Region: AllC; TIGR03176 1016998007303 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1016998007304 active site 1016998007305 metal binding site [ion binding]; metal-binding site 1016998007306 dimer interface [polypeptide binding]; other site 1016998007307 Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257 1016998007308 Mif2/CENP-C like; Region: Mif2; pfam11699 1016998007309 Cupin domain; Region: Cupin_2; pfam07883 1016998007310 glycerate kinase II; Provisional; Region: PRK09932 1016998007311 putative uracil/xanthine transporter; Provisional; Region: PRK11412 1016998007312 allantoinase; Provisional; Region: PRK08044 1016998007313 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 1016998007314 active site 1016998007315 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 1016998007316 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1016998007317 Na binding site [ion binding]; other site 1016998007318 putative substrate binding site [chemical binding]; other site 1016998007319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998007320 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1016998007321 putative substrate translocation pore; other site 1016998007322 tartronate semialdehyde reductase; Provisional; Region: PRK15059 1016998007323 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1016998007324 hydroxypyruvate isomerase; Provisional; Region: PRK09997 1016998007325 Glyoxylate carboligase [General function prediction only]; Region: COG3960 1016998007326 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1016998007327 TPP binding site [chemical binding]; other site 1016998007328 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1016998007329 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 1016998007330 TPP-binding site [chemical binding]; other site 1016998007331 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 1016998007332 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1016998007333 Bacterial transcriptional regulator; Region: IclR; pfam01614 1016998007334 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 1016998007335 ureidoglycolate hydrolase; Provisional; Region: PRK03606 1016998007336 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 1016998007337 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998007338 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1016998007339 dimerization interface [polypeptide binding]; other site 1016998007340 Predicted ATPase [General function prediction only]; Region: COG2603 1016998007341 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 1016998007342 active site residue [active] 1016998007343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998007344 dimer interface [polypeptide binding]; other site 1016998007345 conserved gate region; other site 1016998007346 ABC-ATPase subunit interface; other site 1016998007347 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1016998007348 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1016998007349 Walker A/P-loop; other site 1016998007350 ATP binding site [chemical binding]; other site 1016998007351 Q-loop/lid; other site 1016998007352 ABC transporter signature motif; other site 1016998007353 Walker B; other site 1016998007354 D-loop; other site 1016998007355 H-loop/switch region; other site 1016998007356 NIL domain; Region: NIL; pfam09383 1016998007357 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1016998007358 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1016998007359 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1016998007360 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1016998007361 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1016998007362 FtsX-like permease family; Region: FtsX; pfam02687 1016998007363 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 1016998007364 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1016998007365 Walker A/P-loop; other site 1016998007366 ATP binding site [chemical binding]; other site 1016998007367 Q-loop/lid; other site 1016998007368 ABC transporter signature motif; other site 1016998007369 Walker B; other site 1016998007370 D-loop; other site 1016998007371 H-loop/switch region; other site 1016998007372 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1016998007373 active site 1016998007374 catalytic triad [active] 1016998007375 oxyanion hole [active] 1016998007376 switch loop; other site 1016998007377 oxidoreductase; Provisional; Region: PRK08017 1016998007378 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1016998007379 NADP binding site [chemical binding]; other site 1016998007380 active site 1016998007381 steroid binding site; other site 1016998007382 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1016998007383 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1016998007384 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1016998007385 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 1016998007386 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1016998007387 Walker A/P-loop; other site 1016998007388 ATP binding site [chemical binding]; other site 1016998007389 Q-loop/lid; other site 1016998007390 ABC transporter signature motif; other site 1016998007391 Walker B; other site 1016998007392 D-loop; other site 1016998007393 H-loop/switch region; other site 1016998007394 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1016998007395 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1016998007396 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1016998007397 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 1016998007398 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1016998007399 DNA binding residues [nucleotide binding] 1016998007400 dimer interface [polypeptide binding]; other site 1016998007401 copper binding site [ion binding]; other site 1016998007402 copper exporting ATPase; Provisional; Region: copA; PRK10671 1016998007403 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1016998007404 metal-binding site [ion binding] 1016998007405 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1016998007406 metal-binding site [ion binding] 1016998007407 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1016998007408 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1016998007409 motif II; other site 1016998007410 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1016998007411 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 1016998007412 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1016998007413 putative deacylase active site [active] 1016998007414 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 1016998007415 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 1016998007416 active site 1016998007417 metal binding site [ion binding]; metal-binding site 1016998007418 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1016998007419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998007420 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1016998007421 putative substrate translocation pore; other site 1016998007422 putative cation:proton antiport protein; Provisional; Region: PRK10669 1016998007423 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 1016998007424 TrkA-N domain; Region: TrkA_N; pfam02254 1016998007425 inosine/guanosine kinase; Provisional; Region: PRK15074 1016998007426 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1016998007427 acetyl esterase; Provisional; Region: PRK10162 1016998007428 ferrochelatase; Reviewed; Region: hemH; PRK00035 1016998007429 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1016998007430 C-terminal domain interface [polypeptide binding]; other site 1016998007431 active site 1016998007432 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1016998007433 active site 1016998007434 N-terminal domain interface [polypeptide binding]; other site 1016998007435 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1016998007436 Adenylate kinase; Region: ADK; pfam00406 1016998007437 AMP-binding site [chemical binding]; other site 1016998007438 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1016998007439 heat shock protein 90; Provisional; Region: PRK05218 1016998007440 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1016998007441 ATP binding site [chemical binding]; other site 1016998007442 Mg2+ binding site [ion binding]; other site 1016998007443 G-X-G motif; other site 1016998007444 recombination protein RecR; Reviewed; Region: recR; PRK00076 1016998007445 RecR protein; Region: RecR; pfam02132 1016998007446 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1016998007447 putative active site [active] 1016998007448 putative metal-binding site [ion binding]; other site 1016998007449 tetramer interface [polypeptide binding]; other site 1016998007450 hypothetical protein; Validated; Region: PRK00153 1016998007451 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 1016998007452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1016998007453 Walker A motif; other site 1016998007454 ATP binding site [chemical binding]; other site 1016998007455 Walker B motif; other site 1016998007456 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1016998007457 arginine finger; other site 1016998007458 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1016998007459 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 1016998007460 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 1016998007461 Dnax ribosomal frameshifting element 1016998007462 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1016998007463 active site 1016998007464 hypothetical protein; Provisional; Region: PRK10527 1016998007465 primosomal replication protein N''; Provisional; Region: PRK10093 1016998007466 hypothetical protein; Provisional; Region: PRK11038 1016998007467 Uncharacterized conserved protein [Function unknown]; Region: COG5464 1016998007468 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1016998007469 hypothetical protein; Provisional; Region: PRK11281 1016998007470 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1016998007471 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 1016998007472 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1016998007473 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 1016998007474 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1016998007475 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1016998007476 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1016998007477 HlyD family secretion protein; Region: HlyD_3; pfam13437 1016998007478 Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561 1016998007479 substrate binding site [chemical binding]; other site 1016998007480 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 1016998007481 Protein export membrane protein; Region: SecD_SecF; cl14618 1016998007482 Protein export membrane protein; Region: SecD_SecF; cl14618 1016998007483 Hha toxicity attenuator; Provisional; Region: PRK10667 1016998007484 gene expression modulator; Provisional; Region: PRK10945 1016998007485 maltose O-acetyltransferase; Provisional; Region: PRK10092 1016998007486 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1016998007487 active site 1016998007488 substrate binding site [chemical binding]; other site 1016998007489 trimer interface [polypeptide binding]; other site 1016998007490 CoA binding site [chemical binding]; other site 1016998007491 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 1016998007492 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1016998007493 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1016998007494 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1016998007495 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1016998007496 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1016998007497 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1016998007498 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1016998007499 DNA binding site [nucleotide binding] 1016998007500 active site 1016998007501 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 1016998007502 acyl-CoA thioesterase II; Provisional; Region: PRK10526 1016998007503 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1016998007504 active site 1016998007505 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1016998007506 catalytic triad [active] 1016998007507 dimer interface [polypeptide binding]; other site 1016998007508 ammonium transporter; Provisional; Region: PRK10666 1016998007509 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 1016998007510 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1016998007511 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 1016998007512 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1016998007513 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1016998007514 Walker A/P-loop; other site 1016998007515 ATP binding site [chemical binding]; other site 1016998007516 Q-loop/lid; other site 1016998007517 ABC transporter signature motif; other site 1016998007518 Walker B; other site 1016998007519 D-loop; other site 1016998007520 H-loop/switch region; other site 1016998007521 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1016998007522 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1016998007523 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1016998007524 Walker A/P-loop; other site 1016998007525 ATP binding site [chemical binding]; other site 1016998007526 Q-loop/lid; other site 1016998007527 ABC transporter signature motif; other site 1016998007528 Walker B; other site 1016998007529 D-loop; other site 1016998007530 H-loop/switch region; other site 1016998007531 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1016998007532 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1016998007533 putative DNA binding site [nucleotide binding]; other site 1016998007534 putative Zn2+ binding site [ion binding]; other site 1016998007535 AsnC family; Region: AsnC_trans_reg; pfam01037 1016998007536 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1016998007537 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1016998007538 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1016998007539 catalytic residue [active] 1016998007540 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 1016998007541 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1016998007542 active site 1016998007543 motif I; other site 1016998007544 motif II; other site 1016998007545 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1016998007546 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1016998007547 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1016998007548 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1016998007549 Ligand Binding Site [chemical binding]; other site 1016998007550 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1016998007551 active site 1016998007552 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 1016998007553 periplasmic folding chaperone; Provisional; Region: PRK10788 1016998007554 SurA N-terminal domain; Region: SurA_N_3; cl07813 1016998007555 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1016998007556 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1016998007557 IHF dimer interface [polypeptide binding]; other site 1016998007558 IHF - DNA interface [nucleotide binding]; other site 1016998007559 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 1016998007560 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1016998007561 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1016998007562 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1016998007563 Walker A motif; other site 1016998007564 ATP binding site [chemical binding]; other site 1016998007565 Walker B motif; other site 1016998007566 arginine finger; other site 1016998007567 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1016998007568 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1016998007569 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1016998007570 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1016998007571 Walker A motif; other site 1016998007572 ATP binding site [chemical binding]; other site 1016998007573 Walker B motif; other site 1016998007574 Iron permease FTR1 family; Region: FTR1; cl00475 1016998007575 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1016998007576 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1016998007577 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1016998007578 oligomer interface [polypeptide binding]; other site 1016998007579 active site residues [active] 1016998007580 trigger factor; Provisional; Region: tig; PRK01490 1016998007581 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1016998007582 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1016998007583 transcriptional regulator BolA; Provisional; Region: PRK11628 1016998007584 hypothetical protein; Provisional; Region: PRK11627 1016998007585 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 1016998007586 muropeptide transporter; Reviewed; Region: ampG; PRK11902 1016998007587 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998007588 putative substrate translocation pore; other site 1016998007589 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 1016998007590 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1016998007591 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1016998007592 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1016998007593 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1016998007594 D-pathway; other site 1016998007595 Putative ubiquinol binding site [chemical binding]; other site 1016998007596 Low-spin heme (heme b) binding site [chemical binding]; other site 1016998007597 Putative water exit pathway; other site 1016998007598 Binuclear center (heme o3/CuB) [ion binding]; other site 1016998007599 K-pathway; other site 1016998007600 Putative proton exit pathway; other site 1016998007601 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1016998007602 Subunit I/III interface [polypeptide binding]; other site 1016998007603 Subunit III/IV interface [polypeptide binding]; other site 1016998007604 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 1016998007605 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 1016998007606 UbiA prenyltransferase family; Region: UbiA; pfam01040 1016998007607 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1016998007608 Sel1-like repeats; Region: SEL1; smart00671 1016998007609 Sel1-like repeats; Region: SEL1; smart00671 1016998007610 Sel1-like repeats; Region: SEL1; smart00671 1016998007611 Sel1-like repeats; Region: SEL1; smart00671 1016998007612 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1016998007613 Sel1 repeat; Region: Sel1; pfam08238 1016998007614 Sel1-like repeats; Region: SEL1; smart00671 1016998007615 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998007616 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1016998007617 putative substrate translocation pore; other site 1016998007618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1016998007619 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1016998007620 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 1016998007621 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1016998007622 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1016998007623 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1016998007624 conserved cys residue [active] 1016998007625 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 1016998007626 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1016998007627 motif II; other site 1016998007628 2-aminoethylphosphonate--pyruvate transaminase; Region: transamin_PhnW; TIGR02326 1016998007629 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1016998007630 catalytic residue [active] 1016998007631 transcriptional regulator protein; Region: phnR; TIGR03337 1016998007632 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1016998007633 DNA-binding site [nucleotide binding]; DNA binding site 1016998007634 UTRA domain; Region: UTRA; pfam07702 1016998007635 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 1016998007636 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1016998007637 2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258 1016998007638 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1016998007639 Walker A/P-loop; other site 1016998007640 ATP binding site [chemical binding]; other site 1016998007641 Q-loop/lid; other site 1016998007642 ABC transporter signature motif; other site 1016998007643 Walker B; other site 1016998007644 D-loop; other site 1016998007645 H-loop/switch region; other site 1016998007646 TOBE domain; Region: TOBE_2; pfam08402 1016998007647 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 1016998007648 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998007649 dimer interface [polypeptide binding]; other site 1016998007650 conserved gate region; other site 1016998007651 putative PBP binding loops; other site 1016998007652 ABC-ATPase subunit interface; other site 1016998007653 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1016998007654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998007655 dimer interface [polypeptide binding]; other site 1016998007656 conserved gate region; other site 1016998007657 putative PBP binding loops; other site 1016998007658 ABC-ATPase subunit interface; other site 1016998007659 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 1016998007660 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1016998007661 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1016998007662 Ligand Binding Site [chemical binding]; other site 1016998007663 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1016998007664 active site residue [active] 1016998007665 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1016998007666 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1016998007667 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1016998007668 substrate binding pocket [chemical binding]; other site 1016998007669 chain length determination region; other site 1016998007670 substrate-Mg2+ binding site; other site 1016998007671 catalytic residues [active] 1016998007672 aspartate-rich region 1; other site 1016998007673 active site lid residues [active] 1016998007674 aspartate-rich region 2; other site 1016998007675 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 1016998007676 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1016998007677 TPP-binding site; other site 1016998007678 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1016998007679 PYR/PP interface [polypeptide binding]; other site 1016998007680 dimer interface [polypeptide binding]; other site 1016998007681 TPP binding site [chemical binding]; other site 1016998007682 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1016998007683 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1016998007684 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1016998007685 active site 1016998007686 catalytic tetrad [active] 1016998007687 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1016998007688 tetramer interfaces [polypeptide binding]; other site 1016998007689 binuclear metal-binding site [ion binding]; other site 1016998007690 thiamine monophosphate kinase; Provisional; Region: PRK05731 1016998007691 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1016998007692 ATP binding site [chemical binding]; other site 1016998007693 dimerization interface [polypeptide binding]; other site 1016998007694 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1016998007695 putative RNA binding site [nucleotide binding]; other site 1016998007696 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1016998007697 homopentamer interface [polypeptide binding]; other site 1016998007698 active site 1016998007699 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1016998007700 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1016998007701 catalytic motif [active] 1016998007702 Zn binding site [ion binding]; other site 1016998007703 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 1016998007704 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1016998007705 ATP cone domain; Region: ATP-cone; pfam03477 1016998007706 hypothetical protein; Provisional; Region: PRK11530 1016998007707 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 1016998007708 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 1016998007709 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1016998007710 active site 1016998007711 Predicted transcriptional regulator [Transcription]; Region: COG2378 1016998007712 HTH domain; Region: HTH_11; pfam08279 1016998007713 WYL domain; Region: WYL; pfam13280 1016998007714 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1016998007715 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1016998007716 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1016998007717 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1016998007718 Protein export membrane protein; Region: SecD_SecF; pfam02355 1016998007719 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1016998007720 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1016998007721 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1016998007722 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1016998007723 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1016998007724 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1016998007725 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 1016998007726 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1016998007727 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1016998007728 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 1016998007729 peroxidase; Provisional; Region: PRK15000 1016998007730 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1016998007731 dimer interface [polypeptide binding]; other site 1016998007732 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1016998007733 catalytic triad [active] 1016998007734 peroxidatic and resolving cysteines [active] 1016998007735 maltodextrin glucosidase; Provisional; Region: PRK10785 1016998007736 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1016998007737 homodimer interface [polypeptide binding]; other site 1016998007738 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1016998007739 active site 1016998007740 homodimer interface [polypeptide binding]; other site 1016998007741 catalytic site [active] 1016998007742 putative proline-specific permease; Provisional; Region: proY; PRK10580 1016998007743 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 1016998007744 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 1016998007745 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 1016998007746 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1016998007747 putative active site [active] 1016998007748 heme pocket [chemical binding]; other site 1016998007749 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1016998007750 dimer interface [polypeptide binding]; other site 1016998007751 phosphorylation site [posttranslational modification] 1016998007752 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1016998007753 ATP binding site [chemical binding]; other site 1016998007754 Mg2+ binding site [ion binding]; other site 1016998007755 G-X-G motif; other site 1016998007756 transcriptional regulator PhoB; Provisional; Region: PRK10161 1016998007757 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1016998007758 active site 1016998007759 phosphorylation site [posttranslational modification] 1016998007760 intermolecular recognition site; other site 1016998007761 dimerization interface [polypeptide binding]; other site 1016998007762 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1016998007763 DNA binding site [nucleotide binding] 1016998007764 exonuclease subunit SbcD; Provisional; Region: PRK10966 1016998007765 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1016998007766 active site 1016998007767 metal binding site [ion binding]; metal-binding site 1016998007768 DNA binding site [nucleotide binding] 1016998007769 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1016998007770 exonuclease subunit SbcC; Provisional; Region: PRK10246 1016998007771 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1016998007772 Walker A/P-loop; other site 1016998007773 ATP binding site [chemical binding]; other site 1016998007774 Q-loop/lid; other site 1016998007775 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1016998007776 ABC transporter signature motif; other site 1016998007777 Walker B; other site 1016998007778 D-loop; other site 1016998007779 H-loop/switch region; other site 1016998007780 MFS transport protein AraJ; Provisional; Region: PRK10091 1016998007781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998007782 putative substrate translocation pore; other site 1016998007783 fructokinase; Reviewed; Region: PRK09557 1016998007784 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1016998007785 nucleotide binding site [chemical binding]; other site 1016998007786 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 1016998007787 hypothetical protein; Provisional; Region: PRK10579 1016998007788 hypothetical protein; Provisional; Region: PRK10481 1016998007789 hypothetical protein; Provisional; Region: PRK10380 1016998007790 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1016998007791 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1016998007792 ADP binding site [chemical binding]; other site 1016998007793 magnesium binding site [ion binding]; other site 1016998007794 putative shikimate binding site; other site 1016998007795 hypothetical protein; Validated; Region: PRK00124 1016998007796 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1016998007797 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1016998007798 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 1016998007799 MASE2 domain; Region: MASE2; pfam05230 1016998007800 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1016998007801 metal binding site [ion binding]; metal-binding site 1016998007802 active site 1016998007803 I-site; other site 1016998007804 hypothetical protein; Provisional; Region: PRK11505 1016998007805 psiF repeat; Region: PsiF_repeat; pfam07769 1016998007806 psiF repeat; Region: PsiF_repeat; pfam07769 1016998007807 anti-RssB factor; Provisional; Region: PRK10244 1016998007808 drug efflux system protein MdtG; Provisional; Region: PRK09874 1016998007809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998007810 putative substrate translocation pore; other site 1016998007811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 1016998007812 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 1016998007813 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1016998007814 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1016998007815 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1016998007816 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 1016998007817 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 1016998007818 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 1016998007819 microcin B17 transporter; Reviewed; Region: PRK11098 1016998007820 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 1016998007821 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1016998007822 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 1016998007823 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1016998007824 ligand binding site [chemical binding]; other site 1016998007825 flexible hinge region; other site 1016998007826 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1016998007827 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 1016998007828 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1016998007829 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1016998007830 dimer interface [polypeptide binding]; other site 1016998007831 active site 1016998007832 Schiff base residues; other site 1016998007833 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 1016998007834 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1016998007835 acyl-activating enzyme (AAE) consensus motif; other site 1016998007836 AMP binding site [chemical binding]; other site 1016998007837 active site 1016998007838 CoA binding site [chemical binding]; other site 1016998007839 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 1016998007840 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1016998007841 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1016998007842 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 1016998007843 dimer interface [polypeptide binding]; other site 1016998007844 active site 1016998007845 citrylCoA binding site [chemical binding]; other site 1016998007846 oxalacetate/citrate binding site [chemical binding]; other site 1016998007847 coenzyme A binding site [chemical binding]; other site 1016998007848 catalytic triad [active] 1016998007849 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1016998007850 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1016998007851 tetramer interface [polypeptide binding]; other site 1016998007852 active site 1016998007853 Mg2+/Mn2+ binding site [ion binding]; other site 1016998007854 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 1016998007855 Propionate catabolism activator; Region: PrpR_N; pfam06506 1016998007856 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1016998007857 Walker A motif; other site 1016998007858 ATP binding site [chemical binding]; other site 1016998007859 Walker B motif; other site 1016998007860 arginine finger; other site 1016998007861 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1016998007862 hypothetical protein; Provisional; Region: PRK09929 1016998007863 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 1016998007864 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1016998007865 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1016998007866 N-terminal plug; other site 1016998007867 ligand-binding site [chemical binding]; other site 1016998007868 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1016998007869 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1016998007870 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1016998007871 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1016998007872 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1016998007873 type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483 1016998007874 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1016998007875 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1016998007876 VRR-NUC domain; Region: VRR_NUC; pfam08774 1016998007877 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1016998007878 DNA methylase; Region: N6_N4_Mtase; cl17433 1016998007879 DNA methylase; Region: N6_N4_Mtase; pfam01555 1016998007880 putative sialic acid transporter; Region: 2A0112; TIGR00891 1016998007881 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998007882 putative substrate translocation pore; other site 1016998007883 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1016998007884 metal-binding site [ion binding] 1016998007885 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1016998007886 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1016998007887 DNA binding residues [nucleotide binding] 1016998007888 dimer interface [polypeptide binding]; other site 1016998007889 copper binding site [ion binding]; other site 1016998007890 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1016998007891 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1016998007892 metal-binding site [ion binding] 1016998007893 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1016998007894 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1016998007895 motif II; other site 1016998007896 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1016998007897 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1016998007898 HlyD family secretion protein; Region: HlyD_3; pfam13437 1016998007899 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1016998007900 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1016998007901 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 1016998007902 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 1016998007903 DNA binding residues [nucleotide binding] 1016998007904 dimerization interface [polypeptide binding]; other site 1016998007905 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1016998007906 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1016998007907 DNA binding site [nucleotide binding] 1016998007908 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1016998007909 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1016998007910 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1016998007911 fimbrial chaperone protein StbB; Provisional; Region: PRK15249 1016998007912 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1016998007913 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1016998007914 fimbrial outer membrane usher protein StbC; Provisional; Region: PRK15248 1016998007915 PapC N-terminal domain; Region: PapC_N; pfam13954 1016998007916 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1016998007917 PapC C-terminal domain; Region: PapC_C; pfam13953 1016998007918 putative fimbrial usher protein StbD; Provisional; Region: PRK15247 1016998007919 fimbrial assembly chaperone StbE; Provisional; Region: PRK15246 1016998007920 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1016998007921 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1016998007922 transcriptional activator TtdR; Provisional; Region: PRK09801 1016998007923 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998007924 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 1016998007925 putative effector binding pocket; other site 1016998007926 putative dimerization interface [polypeptide binding]; other site 1016998007927 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1016998007928 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1016998007929 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1016998007930 3-isopropylmalate dehydratase small subunit [Amino acid transport and metabolism]; Region: LeuD; COG0066 1016998007931 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1016998007932 hypothetical protein; Provisional; Region: PRK14812 1016998007933 substrate binding site [chemical binding]; other site 1016998007934 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1016998007935 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1016998007936 substrate binding site [chemical binding]; other site 1016998007937 ligand binding site [chemical binding]; other site 1016998007938 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1016998007939 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998007940 putative substrate translocation pore; other site 1016998007941 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 1016998007942 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1016998007943 Integrase core domain; Region: rve; pfam00665 1016998007944 Integrase core domain; Region: rve_2; pfam13333 1016998007945 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 1016998007946 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1016998007947 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1016998007948 putative catalytic cysteine [active] 1016998007949 gamma-glutamyl kinase; Provisional; Region: PRK05429 1016998007950 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1016998007951 nucleotide binding site [chemical binding]; other site 1016998007952 homotetrameric interface [polypeptide binding]; other site 1016998007953 putative phosphate binding site [ion binding]; other site 1016998007954 putative allosteric binding site; other site 1016998007955 PUA domain; Region: PUA; pfam01472 1016998007956 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1016998007957 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1016998007958 trimer interface [polypeptide binding]; other site 1016998007959 eyelet of channel; other site 1016998007960 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 1016998007961 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 1016998007962 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1016998007963 active site 1016998007964 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 1016998007965 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 1016998007966 metal binding site [ion binding]; metal-binding site 1016998007967 dimer interface [polypeptide binding]; other site 1016998007968 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 1016998007969 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1016998007970 hypothetical protein; Reviewed; Region: PRK09588 1016998007971 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 1016998007972 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1016998007973 active site 1016998007974 DNA polymerase IV; Validated; Region: PRK02406 1016998007975 DNA binding site [nucleotide binding] 1016998007976 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1016998007977 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1016998007978 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1016998007979 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1016998007980 putative active site [active] 1016998007981 putative dimer interface [polypeptide binding]; other site 1016998007982 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1016998007983 dimer interface [polypeptide binding]; other site 1016998007984 active site 1016998007985 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1016998007986 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1016998007987 active site 1016998007988 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1016998007989 C-N hydrolase family amidase; Provisional; Region: PRK10438 1016998007990 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 1016998007991 putative active site [active] 1016998007992 catalytic triad [active] 1016998007993 dimer interface [polypeptide binding]; other site 1016998007994 multimer interface [polypeptide binding]; other site 1016998007995 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1016998007996 dimer interface [polypeptide binding]; other site 1016998007997 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1016998007998 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1016998007999 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998008000 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1016998008001 dimerization interface [polypeptide binding]; other site 1016998008002 PerC transcriptional activator; Region: PerC; pfam06069 1016998008003 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1016998008004 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 1016998008005 putative active site [active] 1016998008006 putative metal binding site [ion binding]; other site 1016998008007 putative pilin structural protein SafD; Provisional; Region: PRK15222 1016998008008 pilin outer membrane usher protein SafC; Provisional; Region: PRK15223 1016998008009 PapC N-terminal domain; Region: PapC_N; pfam13954 1016998008010 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1016998008011 PapC C-terminal domain; Region: PapC_C; pfam13953 1016998008012 pili assembly chaperone protein SafB; Provisional; Region: PRK15224 1016998008013 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1016998008014 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1016998008015 Saf-pilin pilus formation protein SafA; Provisional; Region: PRK15221 1016998008016 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1016998008017 Integrase core domain; Region: rve_3; pfam13683 1016998008018 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1016998008019 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 1016998008020 Predicted GTPase [General function prediction only]; Region: COG3596 1016998008021 YfjP GTPase; Region: YfjP; cd11383 1016998008022 G1 box; other site 1016998008023 GTP/Mg2+ binding site [chemical binding]; other site 1016998008024 Switch I region; other site 1016998008025 G2 box; other site 1016998008026 Switch II region; other site 1016998008027 G3 box; other site 1016998008028 G4 box; other site 1016998008029 G5 box; other site 1016998008030 Predicted transcriptional regulator [Transcription]; Region: COG2378 1016998008031 Stage III sporulation protein D; Region: SpoIIID; cl17560 1016998008032 WYL domain; Region: WYL; pfam13280 1016998008033 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 1016998008034 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 1016998008035 Domain of unknown function (DUF932); Region: DUF932; cl12129 1016998008036 Antirestriction protein; Region: Antirestrict; pfam03230 1016998008037 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1016998008038 MPN+ (JAMM) motif; other site 1016998008039 Zinc-binding site [ion binding]; other site 1016998008040 Protein of unknown function (DUF987); Region: DUF987; pfam06174 1016998008041 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 1016998008042 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 1016998008043 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 1016998008044 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 1016998008045 Methyltransferase domain; Region: Methyltransf_27; pfam13708 1016998008046 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1016998008047 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1016998008048 active site 1016998008049 catalytic site [active] 1016998008050 substrate binding site [chemical binding]; other site 1016998008051 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1016998008052 RNA/DNA hybrid binding site [nucleotide binding]; other site 1016998008053 active site 1016998008054 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1016998008055 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1016998008056 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 1016998008057 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1016998008058 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1016998008059 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1016998008060 catalytic residue [active] 1016998008061 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1016998008062 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1016998008063 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1016998008064 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1016998008065 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1016998008066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1016998008067 S-adenosylmethionine binding site [chemical binding]; other site 1016998008068 hypothetical protein; Provisional; Region: PRK05421 1016998008069 putative catalytic site [active] 1016998008070 putative metal binding site [ion binding]; other site 1016998008071 putative phosphate binding site [ion binding]; other site 1016998008072 putative catalytic site [active] 1016998008073 putative phosphate binding site [ion binding]; other site 1016998008074 putative metal binding site [ion binding]; other site 1016998008075 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1016998008076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998008077 putative substrate translocation pore; other site 1016998008078 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1016998008079 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998008080 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 1016998008081 putative effector binding pocket; other site 1016998008082 dimerization interface [polypeptide binding]; other site 1016998008083 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1016998008084 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1016998008085 active site 1016998008086 catalytic tetrad [active] 1016998008087 protein disaggregation chaperone; Provisional; Region: PRK10865 1016998008088 Clp amino terminal domain; Region: Clp_N; pfam02861 1016998008089 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1016998008090 Walker A motif; other site 1016998008091 ATP binding site [chemical binding]; other site 1016998008092 Walker B motif; other site 1016998008093 arginine finger; other site 1016998008094 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1016998008095 Walker A motif; other site 1016998008096 ATP binding site [chemical binding]; other site 1016998008097 Walker B motif; other site 1016998008098 arginine finger; other site 1016998008099 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1016998008100 hypothetical protein; Provisional; Region: PRK10723 1016998008101 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1016998008102 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1016998008103 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1016998008104 RNA binding surface [nucleotide binding]; other site 1016998008105 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1016998008106 active site 1016998008107 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 1016998008108 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 1016998008109 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1016998008110 30S subunit binding site; other site 1016998008111 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 1016998008112 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 1016998008113 Prephenate dehydratase; Region: PDT; pfam00800 1016998008114 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1016998008115 putative L-Phe binding site [chemical binding]; other site 1016998008116 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1016998008117 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 1016998008118 Chorismate mutase type II; Region: CM_2; cl00693 1016998008119 prephenate dehydrogenase; Validated; Region: PRK08507 1016998008120 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1016998008121 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1016998008122 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 1016998008123 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 1016998008124 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1016998008125 metal binding site [ion binding]; metal-binding site 1016998008126 active site 1016998008127 I-site; other site 1016998008128 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1016998008129 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1016998008130 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1016998008131 RimM N-terminal domain; Region: RimM; pfam01782 1016998008132 PRC-barrel domain; Region: PRC; pfam05239 1016998008133 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1016998008134 signal recognition particle protein; Provisional; Region: PRK10867 1016998008135 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1016998008136 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1016998008137 P loop; other site 1016998008138 GTP binding site [chemical binding]; other site 1016998008139 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1016998008140 hypothetical protein; Provisional; Region: PRK11573 1016998008141 Domain of unknown function DUF21; Region: DUF21; pfam01595 1016998008142 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1016998008143 Transporter associated domain; Region: CorC_HlyC; smart01091 1016998008144 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1016998008145 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1016998008146 dimer interface [polypeptide binding]; other site 1016998008147 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1016998008148 recombination and repair protein; Provisional; Region: PRK10869 1016998008149 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1016998008150 Walker A/P-loop; other site 1016998008151 ATP binding site [chemical binding]; other site 1016998008152 Q-loop/lid; other site 1016998008153 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1016998008154 ABC transporter signature motif; other site 1016998008155 Walker B; other site 1016998008156 D-loop; other site 1016998008157 H-loop/switch region; other site 1016998008158 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 1016998008159 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1016998008160 hypothetical protein; Validated; Region: PRK01777 1016998008161 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1016998008162 putative coenzyme Q binding site [chemical binding]; other site 1016998008163 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1016998008164 SmpB-tmRNA interface; other site 1016998008165 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1016998008166 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1016998008167 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1016998008168 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1016998008169 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1016998008170 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1016998008171 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1016998008172 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1016998008173 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1016998008174 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1016998008175 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1016998008176 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1016998008177 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1016998008178 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1016998008179 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1016998008180 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1016998008181 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 1016998008182 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1016998008183 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 1016998008184 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1016998008185 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1016998008186 Walker A/P-loop; other site 1016998008187 ATP binding site [chemical binding]; other site 1016998008188 Q-loop/lid; other site 1016998008189 ABC transporter signature motif; other site 1016998008190 Walker B; other site 1016998008191 D-loop; other site 1016998008192 H-loop/switch region; other site 1016998008193 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1016998008194 HlyD family secretion protein; Region: HlyD_3; pfam13437 1016998008195 integrase; Provisional; Region: PRK09692 1016998008196 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1016998008197 active site 1016998008198 Int/Topo IB signature motif; other site 1016998008199 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1016998008200 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1016998008201 motif II; other site 1016998008202 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 1016998008203 putative active site [active] 1016998008204 putative metal binding site [ion binding]; other site 1016998008205 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1016998008206 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 1016998008207 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 1016998008208 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 1016998008209 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1016998008210 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 1016998008211 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 1016998008212 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1016998008213 active site 1016998008214 metal binding site [ion binding]; metal-binding site 1016998008215 D5 N terminal like; Region: D5_N; smart00885 1016998008216 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 1016998008217 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 1016998008218 integrase; Provisional; Region: PRK09692 1016998008219 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1016998008220 active site 1016998008221 Int/Topo IB signature motif; other site 1016998008222 Domain of unknown function DUF87; Region: DUF87; pfam01935 1016998008223 HerA helicase [Replication, recombination, and repair]; Region: COG0433 1016998008224 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 1016998008225 Repressor of phase-1 flagellin; Region: Flag1_repress; pfam03614 1016998008226 flagellin; Validated; Region: PRK08026 1016998008227 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1016998008228 Flagellin D3 domain; Region: Flagellin_D3; pfam08884 1016998008229 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1016998008230 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1016998008231 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1016998008232 catalytic residues [active] 1016998008233 catalytic nucleophile [active] 1016998008234 Presynaptic Site I dimer interface [polypeptide binding]; other site 1016998008235 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1016998008236 Synaptic Flat tetramer interface [polypeptide binding]; other site 1016998008237 Synaptic Site I dimer interface [polypeptide binding]; other site 1016998008238 DNA binding site [nucleotide binding] 1016998008239 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1016998008240 DNA-binding interface [nucleotide binding]; DNA binding site 1016998008241 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1016998008242 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1016998008243 homodimer interface [polypeptide binding]; other site 1016998008244 active site 1016998008245 TDP-binding site; other site 1016998008246 acceptor substrate-binding pocket; other site 1016998008247 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1016998008248 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1016998008249 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1016998008250 Walker A/P-loop; other site 1016998008251 ATP binding site [chemical binding]; other site 1016998008252 Q-loop/lid; other site 1016998008253 ABC transporter signature motif; other site 1016998008254 Walker B; other site 1016998008255 D-loop; other site 1016998008256 H-loop/switch region; other site 1016998008257 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1016998008258 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1016998008259 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1016998008260 Walker A/P-loop; other site 1016998008261 ATP binding site [chemical binding]; other site 1016998008262 Q-loop/lid; other site 1016998008263 ABC transporter signature motif; other site 1016998008264 Walker B; other site 1016998008265 D-loop; other site 1016998008266 H-loop/switch region; other site 1016998008267 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1016998008268 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 1016998008269 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1016998008270 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1016998008271 outer membrane receptor FepA; Provisional; Region: PRK13528 1016998008272 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1016998008273 N-terminal plug; other site 1016998008274 ligand-binding site [chemical binding]; other site 1016998008275 secreted effector protein PipB2; Provisional; Region: PRK15196 1016998008276 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1016998008277 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1016998008278 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1016998008279 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1016998008280 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1016998008281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 1016998008282 antimicrobial resistance protein Mig-14; Provisional; Region: PRK15312 1016998008283 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1016998008284 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1016998008285 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1016998008286 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1016998008287 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1016998008288 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1016998008289 dimer interface [polypeptide binding]; other site 1016998008290 phosphorylation site [posttranslational modification] 1016998008291 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1016998008292 ATP binding site [chemical binding]; other site 1016998008293 Mg2+ binding site [ion binding]; other site 1016998008294 G-X-G motif; other site 1016998008295 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 1016998008296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1016998008297 active site 1016998008298 phosphorylation site [posttranslational modification] 1016998008299 intermolecular recognition site; other site 1016998008300 dimerization interface [polypeptide binding]; other site 1016998008301 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1016998008302 DNA binding site [nucleotide binding] 1016998008303 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1016998008304 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1016998008305 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1016998008306 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 1016998008307 substrate binding pocket [chemical binding]; other site 1016998008308 active site 1016998008309 iron coordination sites [ion binding]; other site 1016998008310 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1016998008311 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1016998008312 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 1016998008313 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1016998008314 tetramerization interface [polypeptide binding]; other site 1016998008315 NAD(P) binding site [chemical binding]; other site 1016998008316 catalytic residues [active] 1016998008317 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 1016998008318 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1016998008319 inhibitor-cofactor binding pocket; inhibition site 1016998008320 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998008321 catalytic residue [active] 1016998008322 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 1016998008323 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 1016998008324 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1016998008325 DNA-binding site [nucleotide binding]; DNA binding site 1016998008326 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1016998008327 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1016998008328 bacterial OsmY and nodulation domain; Region: BON; smart00749 1016998008329 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1016998008330 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 1016998008331 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1016998008332 dimerization interface [polypeptide binding]; other site 1016998008333 putative DNA binding site [nucleotide binding]; other site 1016998008334 putative Zn2+ binding site [ion binding]; other site 1016998008335 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1016998008336 active site residue [active] 1016998008337 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1016998008338 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 1016998008339 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1016998008340 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 1016998008341 hypothetical protein; Provisional; Region: PRK10556 1016998008342 hypothetical protein; Provisional; Region: PRK10132 1016998008343 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1016998008344 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1016998008345 DNA-binding site [nucleotide binding]; DNA binding site 1016998008346 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1016998008347 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998008348 homodimer interface [polypeptide binding]; other site 1016998008349 catalytic residue [active] 1016998008350 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1016998008351 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1016998008352 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1016998008353 catalytic residues [active] 1016998008354 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1016998008355 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1016998008356 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1016998008357 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1016998008358 active site 1016998008359 dimer interface [polypeptide binding]; other site 1016998008360 catalytic residues [active] 1016998008361 effector binding site; other site 1016998008362 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1016998008363 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1016998008364 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1016998008365 dimer interface [polypeptide binding]; other site 1016998008366 putative radical transfer pathway; other site 1016998008367 diiron center [ion binding]; other site 1016998008368 tyrosyl radical; other site 1016998008369 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 1016998008370 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1016998008371 Walker A/P-loop; other site 1016998008372 ATP binding site [chemical binding]; other site 1016998008373 Q-loop/lid; other site 1016998008374 ABC transporter signature motif; other site 1016998008375 Walker B; other site 1016998008376 D-loop; other site 1016998008377 H-loop/switch region; other site 1016998008378 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1016998008379 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1016998008380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998008381 dimer interface [polypeptide binding]; other site 1016998008382 conserved gate region; other site 1016998008383 putative PBP binding loops; other site 1016998008384 ABC-ATPase subunit interface; other site 1016998008385 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 1016998008386 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1016998008387 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1016998008388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998008389 transcriptional repressor MprA; Provisional; Region: PRK10870 1016998008390 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1016998008391 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 1016998008392 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1016998008393 HlyD family secretion protein; Region: HlyD_3; pfam13437 1016998008394 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1016998008395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998008396 putative substrate translocation pore; other site 1016998008397 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998008398 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 1016998008399 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1016998008400 glutamate--cysteine ligase; Provisional; Region: PRK02107 1016998008401 Predicted membrane protein [Function unknown]; Region: COG1238 1016998008402 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 1016998008403 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1016998008404 motif II; other site 1016998008405 carbon storage regulator; Provisional; Region: PRK01712 1016998008406 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1016998008407 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1016998008408 motif 1; other site 1016998008409 active site 1016998008410 motif 2; other site 1016998008411 motif 3; other site 1016998008412 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1016998008413 DHHA1 domain; Region: DHHA1; pfam02272 1016998008414 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1016998008415 recombinase A; Provisional; Region: recA; PRK09354 1016998008416 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1016998008417 hexamer interface [polypeptide binding]; other site 1016998008418 Walker A motif; other site 1016998008419 ATP binding site [chemical binding]; other site 1016998008420 Walker B motif; other site 1016998008421 hypothetical protein; Validated; Region: PRK03661 1016998008422 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1016998008423 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1016998008424 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1016998008425 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 1016998008426 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 1016998008427 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1016998008428 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 1016998008429 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 1016998008430 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 1016998008431 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 1016998008432 putative NAD(P) binding site [chemical binding]; other site 1016998008433 active site 1016998008434 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 1016998008435 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 1016998008436 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1016998008437 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1016998008438 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 1016998008439 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1016998008440 putative active site [active] 1016998008441 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1016998008442 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 1016998008443 GAF domain; Region: GAF; pfam01590 1016998008444 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1016998008445 Walker A motif; other site 1016998008446 ATP binding site [chemical binding]; other site 1016998008447 Walker B motif; other site 1016998008448 arginine finger; other site 1016998008449 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 1016998008450 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1016998008451 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1016998008452 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1016998008453 iron binding site [ion binding]; other site 1016998008454 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 1016998008455 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1016998008456 Acylphosphatase; Region: Acylphosphatase; pfam00708 1016998008457 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1016998008458 HypF finger; Region: zf-HYPF; pfam07503 1016998008459 HypF finger; Region: zf-HYPF; pfam07503 1016998008460 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1016998008461 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1016998008462 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 1016998008463 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 1016998008464 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 1016998008465 nickel binding site [ion binding]; other site 1016998008466 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 1016998008467 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1016998008468 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 1016998008469 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1016998008470 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 1016998008471 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1016998008472 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1016998008473 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1016998008474 NADH dehydrogenase; Region: NADHdh; cl00469 1016998008475 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 1016998008476 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1016998008477 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1016998008478 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 1016998008479 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 1016998008480 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 1016998008481 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 1016998008482 hydrogenase assembly chaperone; Provisional; Region: PRK10409 1016998008483 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 1016998008484 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 1016998008485 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 1016998008486 dimerization interface [polypeptide binding]; other site 1016998008487 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 1016998008488 ATP binding site [chemical binding]; other site 1016998008489 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 1016998008490 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1016998008491 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1016998008492 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1016998008493 Walker A motif; other site 1016998008494 ATP binding site [chemical binding]; other site 1016998008495 Walker B motif; other site 1016998008496 arginine finger; other site 1016998008497 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1016998008498 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 1016998008499 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1016998008500 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1016998008501 metal binding site [ion binding]; metal-binding site 1016998008502 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 1016998008503 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1016998008504 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1016998008505 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1016998008506 ABC-ATPase subunit interface; other site 1016998008507 dimer interface [polypeptide binding]; other site 1016998008508 putative PBP binding regions; other site 1016998008509 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1016998008510 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1016998008511 ABC-ATPase subunit interface; other site 1016998008512 dimer interface [polypeptide binding]; other site 1016998008513 putative PBP binding regions; other site 1016998008514 transcriptional activator SprB; Provisional; Region: PRK15320 1016998008515 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 1016998008516 transcriptional regulator SirC; Provisional; Region: PRK15044 1016998008517 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1016998008518 putative type III secretion system effector protein OrgC; Provisional; Region: PRK15321 1016998008519 invasion protein OrgB; Provisional; Region: PRK15322 1016998008520 type III secretion apparatus protein OrgA/MxiK; Region: OrgA_MxiK; TIGR02555 1016998008521 invasion protein OrgA; Provisional; Region: PRK15323 1016998008522 type III secretion system lipoprotein PrgK; Provisional; Region: PRK15324 1016998008523 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 1016998008524 type III secretion system needle complex protein PrgI; Provisional; Region: PRK15326 1016998008525 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327 1016998008526 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 1016998008527 transcriptional regulator HilD; Provisional; Region: PRK15185 1016998008528 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1016998008529 invasion protein regulator; Provisional; Region: PRK12370 1016998008530 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1016998008531 DNA binding site [nucleotide binding] 1016998008532 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1016998008533 binding surface 1016998008534 TPR motif; other site 1016998008535 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1016998008536 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1016998008537 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1016998008538 catalytic residue [active] 1016998008539 pathogenicity island 1 effector protein StpP; Provisional; Region: PRK15375 1016998008540 SicP binding; Region: SicP-binding; pfam09119 1016998008541 GTPase-activating protein (GAP) domain found in bacterial cytotoxins, ExoS, SptP, and YopE. Part of protein secretion system; stimulates Rac1- dependent cytoskeletal changes that promote bacterial internalization; Region: ToxGAP; cd00219 1016998008542 switch II binding region; other site 1016998008543 Rac1 P-loop interaction site [polypeptide binding]; other site 1016998008544 GTP binding residues [chemical binding]; other site 1016998008545 switch I binding region; other site 1016998008546 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047 1016998008547 active site 1016998008548 chaperone protein SicP; Provisional; Region: PRK15329 1016998008549 putative acyl carrier protein IacP; Validated; Region: PRK08172 1016998008550 pathogenicity island 1 effector protein SipA; Provisional; Region: PRK15376 1016998008551 cell invasion protein SipD; Provisional; Region: PRK15330 1016998008552 pathogenicity island 1 effector protein SipC; Provisional; Region: PRK15373 1016998008553 pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374 1016998008554 chaperone protein SicA; Provisional; Region: PRK15331 1016998008555 Tetratricopeptide repeat; Region: TPR_3; pfam07720 1016998008556 Tetratricopeptide repeat; Region: TPR_3; pfam07720 1016998008557 type III secretion system protein SpaS; Validated; Region: PRK08156 1016998008558 type III secretion system protein SpaR; Provisional; Region: PRK15332 1016998008559 type III secretion system protein SpaQ; Provisional; Region: PRK15333 1016998008560 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 1016998008561 type III secretion system protein SpaO; Validated; Region: PRK08158 1016998008562 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 1016998008563 antigen presentation protein SpaN; Provisional; Region: PRK15334 1016998008564 Surface presentation of antigens protein; Region: SPAN; pfam02510 1016998008565 Salmonella surface presentation of antigen gene type M protein; Region: SPAM; pfam02090 1016998008566 ATP synthase SpaL; Validated; Region: PRK08149 1016998008567 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1016998008568 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1016998008569 Walker A motif; other site 1016998008570 ATP binding site [chemical binding]; other site 1016998008571 Walker B motif; other site 1016998008572 Invasion protein B family; Region: Invas_SpaK; cl04129 1016998008573 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 1016998008574 type III secretion system protein InvA; Provisional; Region: PRK15337 1016998008575 type III secretion system regulator InvE; Provisional; Region: PRK15338 1016998008576 type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568 1016998008577 type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339 1016998008578 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1016998008579 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1016998008580 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1016998008581 transcriptional regulator InvF; Provisional; Region: PRK15340 1016998008582 InvH outer membrane lipoprotein; Region: InvH; pfam04741 1016998008583 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1016998008584 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1016998008585 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 1016998008586 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1016998008587 active site 1016998008588 metal binding site [ion binding]; metal-binding site 1016998008589 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1016998008590 MutS domain I; Region: MutS_I; pfam01624 1016998008591 MutS domain II; Region: MutS_II; pfam05188 1016998008592 MutS domain III; Region: MutS_III; pfam05192 1016998008593 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1016998008594 Walker A/P-loop; other site 1016998008595 ATP binding site [chemical binding]; other site 1016998008596 Q-loop/lid; other site 1016998008597 ABC transporter signature motif; other site 1016998008598 Walker B; other site 1016998008599 D-loop; other site 1016998008600 H-loop/switch region; other site 1016998008601 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 1016998008602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998008603 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1016998008604 putative substrate translocation pore; other site 1016998008605 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1016998008606 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998008607 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1016998008608 putative effector binding pocket; other site 1016998008609 dimerization interface [polypeptide binding]; other site 1016998008610 GntP family permease; Region: GntP_permease; pfam02447 1016998008611 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1016998008612 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1016998008613 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 1016998008614 putative NAD(P) binding site [chemical binding]; other site 1016998008615 active site 1016998008616 putative substrate binding site [chemical binding]; other site 1016998008617 hypothetical protein; Provisional; Region: PRK09989 1016998008618 putative aldolase; Validated; Region: PRK08130 1016998008619 intersubunit interface [polypeptide binding]; other site 1016998008620 active site 1016998008621 Zn2+ binding site [ion binding]; other site 1016998008622 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1016998008623 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1016998008624 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1016998008625 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1016998008626 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1016998008627 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1016998008628 MarR family; Region: MarR_2; cl17246 1016998008629 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1016998008630 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1016998008631 Flavoprotein; Region: Flavoprotein; pfam02441 1016998008632 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 1016998008633 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 1016998008634 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1016998008635 Peptidase family M23; Region: Peptidase_M23; pfam01551 1016998008636 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1016998008637 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1016998008638 S-adenosylmethionine binding site [chemical binding]; other site 1016998008639 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1016998008640 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 1016998008641 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 1016998008642 Permutation of conserved domain; other site 1016998008643 active site 1016998008644 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1016998008645 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1016998008646 homotrimer interaction site [polypeptide binding]; other site 1016998008647 zinc binding site [ion binding]; other site 1016998008648 CDP-binding sites; other site 1016998008649 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1016998008650 substrate binding site; other site 1016998008651 dimer interface; other site 1016998008652 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 1016998008653 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1016998008654 Cwf15/Cwc15 cell cycle control protein; Region: Cwf_Cwc_15; pfam04889 1016998008655 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 1016998008656 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1016998008657 ligand-binding site [chemical binding]; other site 1016998008658 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 1016998008659 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1016998008660 CysD dimerization site [polypeptide binding]; other site 1016998008661 G1 box; other site 1016998008662 putative GEF interaction site [polypeptide binding]; other site 1016998008663 GTP/Mg2+ binding site [chemical binding]; other site 1016998008664 Switch I region; other site 1016998008665 G2 box; other site 1016998008666 G3 box; other site 1016998008667 Switch II region; other site 1016998008668 G4 box; other site 1016998008669 G5 box; other site 1016998008670 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1016998008671 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1016998008672 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1016998008673 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1016998008674 Active Sites [active] 1016998008675 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 1016998008676 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1016998008677 metal binding site [ion binding]; metal-binding site 1016998008678 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1016998008679 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 1016998008680 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1016998008681 pathogenicity island 1 effector protein SopD; Provisional; Region: PRK15379 1016998008682 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1016998008683 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1016998008684 Active Sites [active] 1016998008685 sulfite reductase subunit beta; Provisional; Region: PRK13504 1016998008686 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1016998008687 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1016998008688 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 1016998008689 Flavodoxin; Region: Flavodoxin_1; pfam00258 1016998008690 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1016998008691 FAD binding pocket [chemical binding]; other site 1016998008692 FAD binding motif [chemical binding]; other site 1016998008693 catalytic residues [active] 1016998008694 NAD binding pocket [chemical binding]; other site 1016998008695 phosphate binding motif [ion binding]; other site 1016998008696 beta-alpha-beta structure motif; other site 1016998008697 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1016998008698 active site 1016998008699 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 1016998008700 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1016998008701 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1016998008702 enolase; Provisional; Region: eno; PRK00077 1016998008703 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1016998008704 dimer interface [polypeptide binding]; other site 1016998008705 metal binding site [ion binding]; metal-binding site 1016998008706 substrate binding pocket [chemical binding]; other site 1016998008707 CTP synthetase; Validated; Region: pyrG; PRK05380 1016998008708 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1016998008709 Catalytic site [active] 1016998008710 active site 1016998008711 UTP binding site [chemical binding]; other site 1016998008712 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1016998008713 active site 1016998008714 putative oxyanion hole; other site 1016998008715 catalytic triad [active] 1016998008716 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1016998008717 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1016998008718 homodimer interface [polypeptide binding]; other site 1016998008719 metal binding site [ion binding]; metal-binding site 1016998008720 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1016998008721 homodimer interface [polypeptide binding]; other site 1016998008722 active site 1016998008723 putative chemical substrate binding site [chemical binding]; other site 1016998008724 metal binding site [ion binding]; metal-binding site 1016998008725 fimbrial protein SteA; Provisional; Region: PRK15261 1016998008726 putative periplasmic fimbrial chaperone protein SteC; Provisional; Region: PRK15274 1016998008727 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1016998008728 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1016998008729 putative fimbrial protein SteD; Provisional; Region: PRK15275 1016998008730 putative fimbrial subunit SteE; Provisional; Region: PRK15276 1016998008731 fimbrial protein SteF; Provisional; Region: PRK15260 1016998008732 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 1016998008733 HD domain; Region: HD_4; pfam13328 1016998008734 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1016998008735 synthetase active site [active] 1016998008736 NTP binding site [chemical binding]; other site 1016998008737 metal binding site [ion binding]; metal-binding site 1016998008738 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1016998008739 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1016998008740 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1016998008741 TRAM domain; Region: TRAM; pfam01938 1016998008742 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1016998008743 S-adenosylmethionine binding site [chemical binding]; other site 1016998008744 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 1016998008745 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 1016998008746 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1016998008747 dimerization interface [polypeptide binding]; other site 1016998008748 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1016998008749 dimer interface [polypeptide binding]; other site 1016998008750 phosphorylation site [posttranslational modification] 1016998008751 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1016998008752 ATP binding site [chemical binding]; other site 1016998008753 Mg2+ binding site [ion binding]; other site 1016998008754 G-X-G motif; other site 1016998008755 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 1016998008756 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1016998008757 active site 1016998008758 phosphorylation site [posttranslational modification] 1016998008759 intermolecular recognition site; other site 1016998008760 dimerization interface [polypeptide binding]; other site 1016998008761 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1016998008762 putative binding surface; other site 1016998008763 active site 1016998008764 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1016998008765 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1016998008766 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1016998008767 active site 1016998008768 tetramer interface [polypeptide binding]; other site 1016998008769 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1016998008770 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1016998008771 active site 1016998008772 tetramer interface [polypeptide binding]; other site 1016998008773 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998008774 D-galactonate transporter; Region: 2A0114; TIGR00893 1016998008775 putative substrate translocation pore; other site 1016998008776 flavodoxin; Provisional; Region: PRK08105 1016998008777 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1016998008778 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 1016998008779 probable active site [active] 1016998008780 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 1016998008781 SecY interacting protein Syd; Provisional; Region: PRK04968 1016998008782 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 1016998008783 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 1016998008784 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1016998008785 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1016998008786 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 1016998008787 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1016998008788 serine transporter; Region: stp; TIGR00814 1016998008789 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1016998008790 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1016998008791 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1016998008792 flap endonuclease-like protein; Provisional; Region: PRK09482 1016998008793 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1016998008794 active site 1016998008795 metal binding site 1 [ion binding]; metal-binding site 1016998008796 putative 5' ssDNA interaction site; other site 1016998008797 metal binding site 3; metal-binding site 1016998008798 metal binding site 2 [ion binding]; metal-binding site 1016998008799 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1016998008800 putative DNA binding site [nucleotide binding]; other site 1016998008801 putative metal binding site [ion binding]; other site 1016998008802 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 1016998008803 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1016998008804 dimer interface [polypeptide binding]; other site 1016998008805 active site 1016998008806 metal binding site [ion binding]; metal-binding site 1016998008807 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1016998008808 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1016998008809 intersubunit interface [polypeptide binding]; other site 1016998008810 active site 1016998008811 Zn2+ binding site [ion binding]; other site 1016998008812 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1016998008813 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998008814 putative substrate translocation pore; other site 1016998008815 L-fucose isomerase; Provisional; Region: fucI; PRK10991 1016998008816 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 1016998008817 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1016998008818 trimer interface [polypeptide binding]; other site 1016998008819 substrate binding site [chemical binding]; other site 1016998008820 Mn binding site [ion binding]; other site 1016998008821 L-fuculokinase; Provisional; Region: PRK10331 1016998008822 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1016998008823 nucleotide binding site [chemical binding]; other site 1016998008824 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 1016998008825 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 1016998008826 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1016998008827 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1016998008828 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 1016998008829 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1016998008830 hypothetical protein; Provisional; Region: PRK10873 1016998008831 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1016998008832 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998008833 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1016998008834 dimerization interface [polypeptide binding]; other site 1016998008835 substrate binding pocket [chemical binding]; other site 1016998008836 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1016998008837 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1016998008838 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1016998008839 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1016998008840 catalytic residue [active] 1016998008841 CsdA-binding activator; Provisional; Region: PRK15019 1016998008842 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1016998008843 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 1016998008844 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1016998008845 putative ATP binding site [chemical binding]; other site 1016998008846 putative substrate interface [chemical binding]; other site 1016998008847 murein transglycosylase A; Provisional; Region: mltA; PRK11162 1016998008848 murein hydrolase B; Provisional; Region: PRK10760; cl17906 1016998008849 MltA specific insert domain; Region: MltA; pfam03562 1016998008850 3D domain; Region: 3D; pfam06725 1016998008851 AMIN domain; Region: AMIN; pfam11741 1016998008852 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1016998008853 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1016998008854 active site 1016998008855 metal binding site [ion binding]; metal-binding site 1016998008856 N-acetylglutamate synthase; Validated; Region: PRK05279 1016998008857 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1016998008858 putative feedback inhibition sensing region; other site 1016998008859 putative nucleotide binding site [chemical binding]; other site 1016998008860 putative substrate binding site [chemical binding]; other site 1016998008861 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1016998008862 Coenzyme A binding pocket [chemical binding]; other site 1016998008863 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 1016998008864 AAA domain; Region: AAA_30; pfam13604 1016998008865 Family description; Region: UvrD_C_2; pfam13538 1016998008866 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 1016998008867 protease3; Provisional; Region: PRK15101 1016998008868 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1016998008869 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1016998008870 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1016998008871 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 1016998008872 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1016998008873 hypothetical protein; Provisional; Region: PRK10332 1016998008874 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 1016998008875 hypothetical protein; Provisional; Region: PRK11521 1016998008876 hypothetical protein; Provisional; Region: PRK10557 1016998008877 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1016998008878 hypothetical protein; Provisional; Region: PRK10506 1016998008879 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1016998008880 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1016998008881 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1016998008882 dimerization interface [polypeptide binding]; other site 1016998008883 active site 1016998008884 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1016998008885 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 1016998008886 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1016998008887 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1016998008888 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1016998008889 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1016998008890 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1016998008891 putative active site [active] 1016998008892 Ap4A binding site [chemical binding]; other site 1016998008893 nudix motif; other site 1016998008894 putative metal binding site [ion binding]; other site 1016998008895 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 1016998008896 putative DNA-binding cleft [nucleotide binding]; other site 1016998008897 putative DNA clevage site; other site 1016998008898 molecular lever; other site 1016998008899 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1016998008900 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1016998008901 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1016998008902 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1016998008903 active site 1016998008904 catalytic tetrad [active] 1016998008905 lysophospholipid transporter LplT; Provisional; Region: PRK11195 1016998008906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998008907 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 1016998008908 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1016998008909 putative acyl-acceptor binding pocket; other site 1016998008910 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 1016998008911 acyl-activating enzyme (AAE) consensus motif; other site 1016998008912 putative AMP binding site [chemical binding]; other site 1016998008913 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 1016998008914 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1016998008915 DNA binding site [nucleotide binding] 1016998008916 domain linker motif; other site 1016998008917 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1016998008918 dimerization interface (closed form) [polypeptide binding]; other site 1016998008919 ligand binding site [chemical binding]; other site 1016998008920 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1016998008921 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1016998008922 DNA binding site [nucleotide binding] 1016998008923 domain linker motif; other site 1016998008924 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1016998008925 dimerization interface (closed form) [polypeptide binding]; other site 1016998008926 ligand binding site [chemical binding]; other site 1016998008927 diaminopimelate decarboxylase; Provisional; Region: PRK11165 1016998008928 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1016998008929 active site 1016998008930 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1016998008931 substrate binding site [chemical binding]; other site 1016998008932 catalytic residues [active] 1016998008933 dimer interface [polypeptide binding]; other site 1016998008934 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1016998008935 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998008936 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1016998008937 dimerization interface [polypeptide binding]; other site 1016998008938 putative racemase; Provisional; Region: PRK10200 1016998008939 aspartate racemase; Region: asp_race; TIGR00035 1016998008940 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1016998008941 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998008942 putative substrate translocation pore; other site 1016998008943 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998008944 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 1016998008945 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1016998008946 NADP binding site [chemical binding]; other site 1016998008947 homodimer interface [polypeptide binding]; other site 1016998008948 active site 1016998008949 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1016998008950 putative acyltransferase; Provisional; Region: PRK05790 1016998008951 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1016998008952 dimer interface [polypeptide binding]; other site 1016998008953 active site 1016998008954 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1016998008955 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998008956 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1016998008957 dimerization interface [polypeptide binding]; other site 1016998008958 Predicted membrane protein [Function unknown]; Region: COG4125 1016998008959 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1016998008960 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1016998008961 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Region: PLN02475 1016998008962 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1016998008963 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1016998008964 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1016998008965 putative metal binding site [ion binding]; other site 1016998008966 putative homodimer interface [polypeptide binding]; other site 1016998008967 putative homotetramer interface [polypeptide binding]; other site 1016998008968 putative homodimer-homodimer interface [polypeptide binding]; other site 1016998008969 putative allosteric switch controlling residues; other site 1016998008970 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 1016998008971 transcriptional activator SprB; Provisional; Region: PRK15320 1016998008972 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14600 1016998008973 Protein of unknown function (DUF1401); Region: DUF1401; pfam07180 1016998008974 Fimbrial protein; Region: Fimbrial; pfam00419 1016998008975 fimbrial chaperone protein StdC; Provisional; Region: PRK15254 1016998008976 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1016998008977 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1016998008978 fimbrial outer membrane usher protein StdB; Provisional; Region: PRK15255 1016998008979 PapC N-terminal domain; Region: PapC_N; pfam13954 1016998008980 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1016998008981 PapC C-terminal domain; Region: PapC_C; pfam13953 1016998008982 fimbrial protein StdA; Provisional; Region: PRK15210 1016998008983 hypothetical protein; Provisional; Region: PRK10316 1016998008984 YfdX protein; Region: YfdX; pfam10938 1016998008985 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1016998008986 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1016998008987 oligomeric interface; other site 1016998008988 putative active site [active] 1016998008989 homodimer interface [polypeptide binding]; other site 1016998008990 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 1016998008991 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1016998008992 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 1016998008993 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1016998008994 Peptidase family M23; Region: Peptidase_M23; pfam01551 1016998008995 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1016998008996 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1016998008997 active site 1016998008998 metal binding site [ion binding]; metal-binding site 1016998008999 nudix motif; other site 1016998009000 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 1016998009001 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1016998009002 dimer interface [polypeptide binding]; other site 1016998009003 putative anticodon binding site; other site 1016998009004 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1016998009005 motif 1; other site 1016998009006 active site 1016998009007 motif 2; other site 1016998009008 motif 3; other site 1016998009009 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1016998009010 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1016998009011 RF-1 domain; Region: RF-1; pfam00472 1016998009012 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1016998009013 DHH family; Region: DHH; pfam01368 1016998009014 DHHA1 domain; Region: DHHA1; pfam02272 1016998009015 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 1016998009016 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1016998009017 dimerization domain [polypeptide binding]; other site 1016998009018 dimer interface [polypeptide binding]; other site 1016998009019 catalytic residues [active] 1016998009020 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1016998009021 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1016998009022 active site 1016998009023 Int/Topo IB signature motif; other site 1016998009024 flavodoxin FldB; Provisional; Region: PRK12359 1016998009025 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 1016998009026 hypothetical protein; Provisional; Region: PRK10878 1016998009027 putative global regulator; Reviewed; Region: PRK09559 1016998009028 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1016998009029 hemolysin; Provisional; Region: PRK15087 1016998009030 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1016998009031 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 1016998009032 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 1016998009033 beta-galactosidase; Region: BGL; TIGR03356 1016998009034 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 1016998009035 glycine dehydrogenase; Provisional; Region: PRK05367 1016998009036 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1016998009037 tetramer interface [polypeptide binding]; other site 1016998009038 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998009039 catalytic residue [active] 1016998009040 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1016998009041 tetramer interface [polypeptide binding]; other site 1016998009042 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998009043 catalytic residue [active] 1016998009044 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1016998009045 lipoyl attachment site [posttranslational modification]; other site 1016998009046 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1016998009047 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1016998009048 oxidoreductase; Provisional; Region: PRK08013 1016998009049 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1016998009050 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 1016998009051 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1016998009052 proline aminopeptidase P II; Provisional; Region: PRK10879 1016998009053 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1016998009054 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1016998009055 active site 1016998009056 hypothetical protein; Reviewed; Region: PRK01736 1016998009057 Z-ring-associated protein; Provisional; Region: PRK10972 1016998009058 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 1016998009059 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1016998009060 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1016998009061 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1016998009062 ligand binding site [chemical binding]; other site 1016998009063 NAD binding site [chemical binding]; other site 1016998009064 tetramer interface [polypeptide binding]; other site 1016998009065 catalytic site [active] 1016998009066 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1016998009067 L-serine binding site [chemical binding]; other site 1016998009068 ACT domain interface; other site 1016998009069 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1016998009070 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1016998009071 active site 1016998009072 dimer interface [polypeptide binding]; other site 1016998009073 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1016998009074 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998009075 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 1016998009076 putative dimerization interface [polypeptide binding]; other site 1016998009077 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1016998009078 oxidative stress defense protein; Provisional; Region: PRK11087 1016998009079 arginine exporter protein; Provisional; Region: PRK09304 1016998009080 mechanosensitive channel MscS; Provisional; Region: PRK10334 1016998009081 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1016998009082 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1016998009083 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 1016998009084 active site 1016998009085 intersubunit interface [polypeptide binding]; other site 1016998009086 zinc binding site [ion binding]; other site 1016998009087 Na+ binding site [ion binding]; other site 1016998009088 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1016998009089 Phosphoglycerate kinase; Region: PGK; pfam00162 1016998009090 substrate binding site [chemical binding]; other site 1016998009091 hinge regions; other site 1016998009092 ADP binding site [chemical binding]; other site 1016998009093 catalytic site [active] 1016998009094 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 1016998009095 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1016998009096 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1016998009097 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 1016998009098 trimer interface [polypeptide binding]; other site 1016998009099 putative Zn binding site [ion binding]; other site 1016998009100 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1016998009101 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1016998009102 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1016998009103 Walker A/P-loop; other site 1016998009104 ATP binding site [chemical binding]; other site 1016998009105 Q-loop/lid; other site 1016998009106 ABC transporter signature motif; other site 1016998009107 Walker B; other site 1016998009108 D-loop; other site 1016998009109 H-loop/switch region; other site 1016998009110 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1016998009111 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1016998009112 Walker A/P-loop; other site 1016998009113 ATP binding site [chemical binding]; other site 1016998009114 Q-loop/lid; other site 1016998009115 ABC transporter signature motif; other site 1016998009116 Walker B; other site 1016998009117 D-loop; other site 1016998009118 H-loop/switch region; other site 1016998009119 transketolase; Reviewed; Region: PRK12753 1016998009120 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1016998009121 TPP-binding site [chemical binding]; other site 1016998009122 dimer interface [polypeptide binding]; other site 1016998009123 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1016998009124 PYR/PP interface [polypeptide binding]; other site 1016998009125 dimer interface [polypeptide binding]; other site 1016998009126 TPP binding site [chemical binding]; other site 1016998009127 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1016998009128 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1016998009129 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1016998009130 agmatinase; Region: agmatinase; TIGR01230 1016998009131 oligomer interface [polypeptide binding]; other site 1016998009132 putative active site [active] 1016998009133 Mn binding site [ion binding]; other site 1016998009134 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1016998009135 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1016998009136 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 1016998009137 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1016998009138 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1016998009139 putative NAD(P) binding site [chemical binding]; other site 1016998009140 catalytic Zn binding site [ion binding]; other site 1016998009141 structural Zn binding site [ion binding]; other site 1016998009142 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1016998009143 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1016998009144 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1016998009145 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1016998009146 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1016998009147 DNA-binding site [nucleotide binding]; DNA binding site 1016998009148 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1016998009149 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 1016998009150 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1016998009151 dimer interface [polypeptide binding]; other site 1016998009152 active site 1016998009153 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1016998009154 catalytic residues [active] 1016998009155 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1016998009156 Virulence promoting factor; Region: YqgB; pfam11036 1016998009157 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 1016998009158 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1016998009159 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1016998009160 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1016998009161 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1016998009162 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1016998009163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998009164 putative substrate translocation pore; other site 1016998009165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998009166 hypothetical protein; Provisional; Region: PRK04860 1016998009167 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1016998009168 DNA-specific endonuclease I; Provisional; Region: PRK15137 1016998009169 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 1016998009170 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1016998009171 RNA methyltransferase, RsmE family; Region: TIGR00046 1016998009172 glutathione synthetase; Provisional; Region: PRK05246 1016998009173 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1016998009174 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1016998009175 hypothetical protein; Validated; Region: PRK00228 1016998009176 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1016998009177 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1016998009178 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1016998009179 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1016998009180 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1016998009181 Walker A motif; other site 1016998009182 ATP binding site [chemical binding]; other site 1016998009183 Walker B motif; other site 1016998009184 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 1016998009185 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1016998009186 catalytic residue [active] 1016998009187 YGGT family; Region: YGGT; pfam02325 1016998009188 YGGT family; Region: YGGT; pfam02325 1016998009189 hypothetical protein; Validated; Region: PRK05090 1016998009190 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1016998009191 active site 1016998009192 dimerization interface [polypeptide binding]; other site 1016998009193 HemN family oxidoreductase; Provisional; Region: PRK05660 1016998009194 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1016998009195 FeS/SAM binding site; other site 1016998009196 HemN C-terminal domain; Region: HemN_C; pfam06969 1016998009197 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 1016998009198 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 1016998009199 homodimer interface [polypeptide binding]; other site 1016998009200 active site 1016998009201 hypothetical protein; Provisional; Region: PRK10626 1016998009202 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 1016998009203 hypothetical protein; Provisional; Region: PRK11702 1016998009204 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1016998009205 adenine DNA glycosylase; Provisional; Region: PRK10880 1016998009206 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1016998009207 minor groove reading motif; other site 1016998009208 helix-hairpin-helix signature motif; other site 1016998009209 substrate binding pocket [chemical binding]; other site 1016998009210 active site 1016998009211 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1016998009212 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1016998009213 DNA binding and oxoG recognition site [nucleotide binding] 1016998009214 oxidative damage protection protein; Provisional; Region: PRK05408 1016998009215 murein transglycosylase C; Provisional; Region: mltC; PRK11671 1016998009216 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 1016998009217 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1016998009218 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1016998009219 catalytic residue [active] 1016998009220 nucleoside transporter; Region: 2A0110; TIGR00889 1016998009221 ornithine decarboxylase; Provisional; Region: PRK13578 1016998009222 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1016998009223 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1016998009224 homodimer interface [polypeptide binding]; other site 1016998009225 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998009226 catalytic residue [active] 1016998009227 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1016998009228 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 1016998009229 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 1016998009230 dimer interface [polypeptide binding]; other site 1016998009231 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1016998009232 metal binding site [ion binding]; metal-binding site 1016998009233 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 1016998009234 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1016998009235 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1016998009236 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1016998009237 putative active site [active] 1016998009238 putative catalytic site [active] 1016998009239 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1016998009240 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1016998009241 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998009242 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 1016998009243 putative dimerization interface [polypeptide binding]; other site 1016998009244 putative substrate binding pocket [chemical binding]; other site 1016998009245 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1016998009246 Sulfatase; Region: Sulfatase; pfam00884 1016998009247 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1016998009248 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1016998009249 FeS/SAM binding site; other site 1016998009250 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1016998009251 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1016998009252 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1016998009253 DNA binding residues [nucleotide binding] 1016998009254 dimerization interface [polypeptide binding]; other site 1016998009255 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 1016998009256 Amino acid permease; Region: AA_permease_2; pfam13520 1016998009257 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 1016998009258 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1016998009259 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1016998009260 Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113 1016998009261 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1016998009262 NAD(P) binding site [chemical binding]; other site 1016998009263 catalytic residues [active] 1016998009264 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 1016998009265 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 1016998009266 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 1016998009267 active site 1016998009268 catalytic site [active] 1016998009269 Zn binding site [ion binding]; other site 1016998009270 tetramer interface [polypeptide binding]; other site 1016998009271 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1016998009272 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 1016998009273 putative active site [active] 1016998009274 catalytic triad [active] 1016998009275 putative dimer interface [polypeptide binding]; other site 1016998009276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998009277 D-galactonate transporter; Region: 2A0114; TIGR00893 1016998009278 putative substrate translocation pore; other site 1016998009279 mannonate dehydratase; Provisional; Region: PRK03906 1016998009280 mannonate dehydratase; Region: uxuA; TIGR00695 1016998009281 D-mannonate oxidoreductase; Provisional; Region: PRK15037 1016998009282 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1016998009283 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1016998009284 Glucuronate isomerase; Region: UxaC; pfam02614 1016998009285 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1016998009286 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1016998009287 dimer interface [polypeptide binding]; other site 1016998009288 putative CheW interface [polypeptide binding]; other site 1016998009289 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 1016998009290 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 1016998009291 CHAP domain; Region: CHAP; pfam05257 1016998009292 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1016998009293 putative S-transferase; Provisional; Region: PRK11752 1016998009294 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1016998009295 C-terminal domain interface [polypeptide binding]; other site 1016998009296 GSH binding site (G-site) [chemical binding]; other site 1016998009297 dimer interface [polypeptide binding]; other site 1016998009298 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 1016998009299 dimer interface [polypeptide binding]; other site 1016998009300 N-terminal domain interface [polypeptide binding]; other site 1016998009301 active site 1016998009302 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1016998009303 molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537 1016998009304 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 1016998009305 putative ligand binding residues [chemical binding]; other site 1016998009306 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1016998009307 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 1016998009308 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 1016998009309 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 1016998009310 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 1016998009311 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 1016998009312 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1016998009313 putative substrate-binding site; other site 1016998009314 nickel binding site [ion binding]; other site 1016998009315 hydrogenase 2 large subunit; Provisional; Region: PRK10467 1016998009316 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1016998009317 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 1016998009318 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1016998009319 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 1016998009320 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1016998009321 hydrogenase 2 small subunit; Provisional; Region: PRK10468 1016998009322 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1016998009323 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1016998009324 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 1016998009325 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 1016998009326 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1016998009327 dimerization interface [polypeptide binding]; other site 1016998009328 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1016998009329 dimer interface [polypeptide binding]; other site 1016998009330 putative CheW interface [polypeptide binding]; other site 1016998009331 hypothetical protein; Provisional; Region: PRK05208 1016998009332 oxidoreductase; Provisional; Region: PRK07985 1016998009333 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1016998009334 NAD binding site [chemical binding]; other site 1016998009335 metal binding site [ion binding]; metal-binding site 1016998009336 active site 1016998009337 biopolymer transport protein ExbD; Provisional; Region: PRK11267 1016998009338 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1016998009339 biopolymer transport protein ExbB; Provisional; Region: PRK10414 1016998009340 cystathionine beta-lyase; Provisional; Region: PRK08114 1016998009341 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1016998009342 homodimer interface [polypeptide binding]; other site 1016998009343 substrate-cofactor binding pocket; other site 1016998009344 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998009345 catalytic residue [active] 1016998009346 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1016998009347 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1016998009348 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1016998009349 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1016998009350 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1016998009351 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1016998009352 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1016998009353 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1016998009354 dimer interface [polypeptide binding]; other site 1016998009355 active site 1016998009356 metal binding site [ion binding]; metal-binding site 1016998009357 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1016998009358 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1016998009359 active site 1016998009360 catalytic tetrad [active] 1016998009361 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1016998009362 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1016998009363 transmembrane helices; other site 1016998009364 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1016998009365 catalytic residue [active] 1016998009366 hypothetical protein; Provisional; Region: PRK01254 1016998009367 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 1016998009368 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 1016998009369 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1016998009370 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1016998009371 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1016998009372 DctM-like transporters; Region: DctM; pfam06808 1016998009373 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 1016998009374 FtsI repressor; Provisional; Region: PRK10883 1016998009375 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1016998009376 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1016998009377 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 1016998009378 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1016998009379 putative acyl-acceptor binding pocket; other site 1016998009380 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 1016998009381 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1016998009382 CAP-like domain; other site 1016998009383 active site 1016998009384 primary dimer interface [polypeptide binding]; other site 1016998009385 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1016998009386 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1016998009387 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1016998009388 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 1016998009389 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 1016998009390 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 1016998009391 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1016998009392 active site 1016998009393 phosphorylation site [posttranslational modification] 1016998009394 intermolecular recognition site; other site 1016998009395 dimerization interface [polypeptide binding]; other site 1016998009396 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1016998009397 DNA binding site [nucleotide binding] 1016998009398 sensor protein QseC; Provisional; Region: PRK10337 1016998009399 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 1016998009400 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1016998009401 dimer interface [polypeptide binding]; other site 1016998009402 phosphorylation site [posttranslational modification] 1016998009403 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1016998009404 ATP binding site [chemical binding]; other site 1016998009405 Mg2+ binding site [ion binding]; other site 1016998009406 G-X-G motif; other site 1016998009407 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1016998009408 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1016998009409 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 1016998009410 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1016998009411 ATP binding site [chemical binding]; other site 1016998009412 Mg2+ binding site [ion binding]; other site 1016998009413 G-X-G motif; other site 1016998009414 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1016998009415 anchoring element; other site 1016998009416 dimer interface [polypeptide binding]; other site 1016998009417 ATP binding site [chemical binding]; other site 1016998009418 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1016998009419 active site 1016998009420 metal binding site [ion binding]; metal-binding site 1016998009421 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1016998009422 esterase YqiA; Provisional; Region: PRK11071 1016998009423 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1016998009424 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1016998009425 active site 1016998009426 metal binding site [ion binding]; metal-binding site 1016998009427 hexamer interface [polypeptide binding]; other site 1016998009428 putative dehydrogenase; Provisional; Region: PRK11039 1016998009429 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1016998009430 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1016998009431 dimer interface [polypeptide binding]; other site 1016998009432 ADP-ribose binding site [chemical binding]; other site 1016998009433 active site 1016998009434 nudix motif; other site 1016998009435 metal binding site [ion binding]; metal-binding site 1016998009436 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 1016998009437 hypothetical protein; Provisional; Region: PRK11653 1016998009438 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1016998009439 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1016998009440 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1016998009441 putative active site [active] 1016998009442 metal binding site [ion binding]; metal-binding site 1016998009443 zinc transporter ZupT; Provisional; Region: PRK04201 1016998009444 ZIP Zinc transporter; Region: Zip; pfam02535 1016998009445 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 1016998009446 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 1016998009447 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1016998009448 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1016998009449 catalytic residues [active] 1016998009450 hinge region; other site 1016998009451 alpha helical domain; other site 1016998009452 putative disulfide oxidoreductase; Provisional; Region: PRK04307 1016998009453 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 1016998009454 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1016998009455 FMN riboswitch (RFN element) 1016998009456 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 1016998009457 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 1016998009458 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 1016998009459 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1016998009460 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1016998009461 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 1016998009462 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1016998009463 putative ribose interaction site [chemical binding]; other site 1016998009464 putative ADP binding site [chemical binding]; other site 1016998009465 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1016998009466 active site 1016998009467 nucleotide binding site [chemical binding]; other site 1016998009468 HIGH motif; other site 1016998009469 KMSKS motif; other site 1016998009470 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1016998009471 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1016998009472 metal binding triad; other site 1016998009473 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1016998009474 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1016998009475 metal binding triad; other site 1016998009476 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1016998009477 Uncharacterized conserved protein [Function unknown]; Region: COG3025 1016998009478 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1016998009479 putative active site [active] 1016998009480 putative metal binding residues [ion binding]; other site 1016998009481 signature motif; other site 1016998009482 putative triphosphate binding site [ion binding]; other site 1016998009483 CHAD domain; Region: CHAD; pfam05235 1016998009484 SH3 domain-containing protein; Provisional; Region: PRK10884 1016998009485 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1016998009486 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1016998009487 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1016998009488 active site 1016998009489 NTP binding site [chemical binding]; other site 1016998009490 metal binding triad [ion binding]; metal-binding site 1016998009491 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1016998009492 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1016998009493 Zn2+ binding site [ion binding]; other site 1016998009494 Mg2+ binding site [ion binding]; other site 1016998009495 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1016998009496 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1016998009497 homooctamer interface [polypeptide binding]; other site 1016998009498 active site 1016998009499 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1016998009500 UGMP family protein; Validated; Region: PRK09604 1016998009501 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1016998009502 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1016998009503 DNA primase; Validated; Region: dnaG; PRK05667 1016998009504 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1016998009505 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1016998009506 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1016998009507 active site 1016998009508 metal binding site [ion binding]; metal-binding site 1016998009509 interdomain interaction site; other site 1016998009510 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1016998009511 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 1016998009512 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1016998009513 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1016998009514 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1016998009515 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1016998009516 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1016998009517 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1016998009518 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1016998009519 DNA binding residues [nucleotide binding] 1016998009520 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1016998009521 active site 1016998009522 SUMO-1 interface [polypeptide binding]; other site 1016998009523 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1016998009524 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1016998009525 FAD binding pocket [chemical binding]; other site 1016998009526 FAD binding motif [chemical binding]; other site 1016998009527 phosphate binding motif [ion binding]; other site 1016998009528 NAD binding pocket [chemical binding]; other site 1016998009529 Predicted transcriptional regulators [Transcription]; Region: COG1695 1016998009530 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1016998009531 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1016998009532 dimerization interface [polypeptide binding]; other site 1016998009533 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1016998009534 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1016998009535 dimer interface [polypeptide binding]; other site 1016998009536 putative CheW interface [polypeptide binding]; other site 1016998009537 PAS fold; Region: PAS_3; pfam08447 1016998009538 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1016998009539 putative active site [active] 1016998009540 heme pocket [chemical binding]; other site 1016998009541 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1016998009542 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1016998009543 dimer interface [polypeptide binding]; other site 1016998009544 putative CheW interface [polypeptide binding]; other site 1016998009545 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 1016998009546 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1016998009547 inhibitor-cofactor binding pocket; inhibition site 1016998009548 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998009549 catalytic residue [active] 1016998009550 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1016998009551 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1016998009552 active site 1016998009553 FMN binding site [chemical binding]; other site 1016998009554 2,4-decadienoyl-CoA binding site; other site 1016998009555 catalytic residue [active] 1016998009556 4Fe-4S cluster binding site [ion binding]; other site 1016998009557 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1016998009558 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1016998009559 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 1016998009560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1016998009561 S-adenosylmethionine binding site [chemical binding]; other site 1016998009562 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 1016998009563 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1016998009564 putative active site [active] 1016998009565 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1016998009566 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1016998009567 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1016998009568 serine/threonine transporter SstT; Provisional; Region: PRK13628 1016998009569 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1016998009570 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1016998009571 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1016998009572 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 1016998009573 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 1016998009574 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 1016998009575 Predicted membrane protein [Function unknown]; Region: COG5393 1016998009576 YqjK-like protein; Region: YqjK; pfam13997 1016998009577 Predicted membrane protein [Function unknown]; Region: COG2259 1016998009578 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1016998009579 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1016998009580 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1016998009581 putative dimer interface [polypeptide binding]; other site 1016998009582 N-terminal domain interface [polypeptide binding]; other site 1016998009583 putative substrate binding pocket (H-site) [chemical binding]; other site 1016998009584 Predicted membrane protein [Function unknown]; Region: COG3152 1016998009585 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998009586 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1016998009587 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1016998009588 dimerization interface [polypeptide binding]; other site 1016998009589 Pirin-related protein [General function prediction only]; Region: COG1741 1016998009590 Pirin; Region: Pirin; pfam02678 1016998009591 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 1016998009592 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1016998009593 serine transporter; Region: stp; TIGR00814 1016998009594 L-serine dehydratase TdcG; Provisional; Region: PRK15040 1016998009595 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1016998009596 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1016998009597 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1016998009598 Pyruvate formate lyase 1; Region: PFL1; cd01678 1016998009599 coenzyme A binding site [chemical binding]; other site 1016998009600 active site 1016998009601 catalytic residues [active] 1016998009602 glycine loop; other site 1016998009603 propionate/acetate kinase; Provisional; Region: PRK12379 1016998009604 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 1016998009605 threonine/serine transporter TdcC; Provisional; Region: PRK13629 1016998009606 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1016998009607 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1016998009608 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1016998009609 tetramer interface [polypeptide binding]; other site 1016998009610 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998009611 catalytic residue [active] 1016998009612 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 1016998009613 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998009614 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 1016998009615 putative substrate binding pocket [chemical binding]; other site 1016998009616 putative dimerization interface [polypeptide binding]; other site 1016998009617 glycerate kinase I; Provisional; Region: PRK10342 1016998009618 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 1016998009619 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1016998009620 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 1016998009621 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1016998009622 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1016998009623 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1016998009624 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1016998009625 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1016998009626 substrate binding site [chemical binding]; other site 1016998009627 ATP binding site [chemical binding]; other site 1016998009628 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1016998009629 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1016998009630 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1016998009631 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1016998009632 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1016998009633 intersubunit interface [polypeptide binding]; other site 1016998009634 active site 1016998009635 zinc binding site [ion binding]; other site 1016998009636 Na+ binding site [ion binding]; other site 1016998009637 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1016998009638 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1016998009639 putative substrate binding site [chemical binding]; other site 1016998009640 putative ATP binding site [chemical binding]; other site 1016998009641 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1016998009642 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1016998009643 active site 1016998009644 P-loop; other site 1016998009645 phosphorylation site [posttranslational modification] 1016998009646 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1016998009647 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1016998009648 active site 1016998009649 phosphorylation site [posttranslational modification] 1016998009650 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1016998009651 dimerization domain swap beta strand [polypeptide binding]; other site 1016998009652 regulatory protein interface [polypeptide binding]; other site 1016998009653 active site 1016998009654 regulatory phosphorylation site [posttranslational modification]; other site 1016998009655 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 1016998009656 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1016998009657 active site 1016998009658 phosphorylation site [posttranslational modification] 1016998009659 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1016998009660 active site 1016998009661 P-loop; other site 1016998009662 phosphorylation site [posttranslational modification] 1016998009663 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1016998009664 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1016998009665 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 1016998009666 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 1016998009667 putative NAD(P) binding site [chemical binding]; other site 1016998009668 catalytic Zn binding site [ion binding]; other site 1016998009669 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1016998009670 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1016998009671 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1016998009672 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 1016998009673 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1016998009674 putative SAM binding site [chemical binding]; other site 1016998009675 putative homodimer interface [polypeptide binding]; other site 1016998009676 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1016998009677 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 1016998009678 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1016998009679 putative ligand binding site [chemical binding]; other site 1016998009680 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 1016998009681 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1016998009682 dimer interface [polypeptide binding]; other site 1016998009683 active site 1016998009684 outer membrane lipoprotein; Provisional; Region: PRK11023 1016998009685 BON domain; Region: BON; pfam04972 1016998009686 BON domain; Region: BON; pfam04972 1016998009687 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 1016998009688 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1016998009689 NAD binding site [chemical binding]; other site 1016998009690 active site 1016998009691 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1016998009692 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1016998009693 proposed catalytic triad [active] 1016998009694 conserved cys residue [active] 1016998009695 hypothetical protein; Provisional; Region: PRK03467 1016998009696 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1016998009697 GIY-YIG motif/motif A; other site 1016998009698 putative active site [active] 1016998009699 putative metal binding site [ion binding]; other site 1016998009700 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1016998009701 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1016998009702 Coenzyme A binding pocket [chemical binding]; other site 1016998009703 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 1016998009704 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1016998009705 Peptidase family U32; Region: Peptidase_U32; pfam01136 1016998009706 putative protease; Provisional; Region: PRK15447 1016998009707 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1016998009708 hypothetical protein; Provisional; Region: PRK10508 1016998009709 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1016998009710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1016998009711 tryptophan permease; Provisional; Region: PRK10483 1016998009712 aromatic amino acid transport protein; Region: araaP; TIGR00837 1016998009713 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1016998009714 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1016998009715 ATP binding site [chemical binding]; other site 1016998009716 Mg++ binding site [ion binding]; other site 1016998009717 motif III; other site 1016998009718 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1016998009719 nucleotide binding region [chemical binding]; other site 1016998009720 ATP-binding site [chemical binding]; other site 1016998009721 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1016998009722 putative RNA binding site [nucleotide binding]; other site 1016998009723 lipoprotein NlpI; Provisional; Region: PRK11189 1016998009724 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1016998009725 binding surface 1016998009726 TPR motif; other site 1016998009727 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1016998009728 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1016998009729 RNase E interface [polypeptide binding]; other site 1016998009730 trimer interface [polypeptide binding]; other site 1016998009731 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1016998009732 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1016998009733 RNase E interface [polypeptide binding]; other site 1016998009734 trimer interface [polypeptide binding]; other site 1016998009735 active site 1016998009736 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1016998009737 putative nucleic acid binding region [nucleotide binding]; other site 1016998009738 G-X-X-G motif; other site 1016998009739 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1016998009740 RNA binding site [nucleotide binding]; other site 1016998009741 domain interface; other site 1016998009742 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1016998009743 S13e-L30e interaction site [polypeptide binding]; other site 1016998009744 16S/18S rRNA binding site [nucleotide binding]; other site 1016998009745 25S rRNA binding site [nucleotide binding]; other site 1016998009746 ribosomal s15 leader 1016998009747 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1016998009748 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1016998009749 RNA binding site [nucleotide binding]; other site 1016998009750 active site 1016998009751 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1016998009752 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1016998009753 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1016998009754 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1016998009755 translation initiation factor IF-2; Region: IF-2; TIGR00487 1016998009756 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1016998009757 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1016998009758 G1 box; other site 1016998009759 putative GEF interaction site [polypeptide binding]; other site 1016998009760 GTP/Mg2+ binding site [chemical binding]; other site 1016998009761 Switch I region; other site 1016998009762 G2 box; other site 1016998009763 G3 box; other site 1016998009764 Switch II region; other site 1016998009765 G4 box; other site 1016998009766 G5 box; other site 1016998009767 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1016998009768 Translation-initiation factor 2; Region: IF-2; pfam11987 1016998009769 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1016998009770 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1016998009771 NusA N-terminal domain; Region: NusA_N; pfam08529 1016998009772 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1016998009773 RNA binding site [nucleotide binding]; other site 1016998009774 homodimer interface [polypeptide binding]; other site 1016998009775 NusA-like KH domain; Region: KH_5; pfam13184 1016998009776 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1016998009777 G-X-X-G motif; other site 1016998009778 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1016998009779 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1016998009780 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1016998009781 Sm and related proteins; Region: Sm_like; cl00259 1016998009782 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1016998009783 putative oligomer interface [polypeptide binding]; other site 1016998009784 putative RNA binding site [nucleotide binding]; other site 1016998009785 argininosuccinate synthase; Validated; Region: PRK05370 1016998009786 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1016998009787 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1016998009788 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1016998009789 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1016998009790 active site 1016998009791 substrate binding site [chemical binding]; other site 1016998009792 metal binding site [ion binding]; metal-binding site 1016998009793 dihydropteroate synthase; Region: DHPS; TIGR01496 1016998009794 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1016998009795 substrate binding pocket [chemical binding]; other site 1016998009796 dimer interface [polypeptide binding]; other site 1016998009797 inhibitor binding site; inhibition site 1016998009798 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 1016998009799 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1016998009800 Walker A motif; other site 1016998009801 ATP binding site [chemical binding]; other site 1016998009802 Walker B motif; other site 1016998009803 arginine finger; other site 1016998009804 Peptidase family M41; Region: Peptidase_M41; pfam01434 1016998009805 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1016998009806 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1016998009807 S-adenosylmethionine binding site [chemical binding]; other site 1016998009808 RNA-binding protein YhbY; Provisional; Region: PRK10343 1016998009809 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1016998009810 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1016998009811 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1016998009812 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 1016998009813 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1016998009814 GTPase CgtA; Reviewed; Region: obgE; PRK12298 1016998009815 GTP1/OBG; Region: GTP1_OBG; pfam01018 1016998009816 Obg GTPase; Region: Obg; cd01898 1016998009817 G1 box; other site 1016998009818 GTP/Mg2+ binding site [chemical binding]; other site 1016998009819 Switch I region; other site 1016998009820 G2 box; other site 1016998009821 G3 box; other site 1016998009822 Switch II region; other site 1016998009823 G4 box; other site 1016998009824 G5 box; other site 1016998009825 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1016998009826 EamA-like transporter family; Region: EamA; pfam00892 1016998009827 EamA-like transporter family; Region: EamA; pfam00892 1016998009828 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1016998009829 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1016998009830 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1016998009831 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1016998009832 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1016998009833 substrate binding pocket [chemical binding]; other site 1016998009834 chain length determination region; other site 1016998009835 substrate-Mg2+ binding site; other site 1016998009836 catalytic residues [active] 1016998009837 aspartate-rich region 1; other site 1016998009838 active site lid residues [active] 1016998009839 aspartate-rich region 2; other site 1016998009840 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 1016998009841 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1016998009842 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1016998009843 hinge; other site 1016998009844 active site 1016998009845 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 1016998009846 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1016998009847 anti sigma factor interaction site; other site 1016998009848 regulatory phosphorylation site [posttranslational modification]; other site 1016998009849 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 1016998009850 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1016998009851 mce related protein; Region: MCE; pfam02470 1016998009852 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1016998009853 conserved hypothetical integral membrane protein; Region: TIGR00056 1016998009854 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 1016998009855 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1016998009856 Walker A/P-loop; other site 1016998009857 ATP binding site [chemical binding]; other site 1016998009858 Q-loop/lid; other site 1016998009859 ABC transporter signature motif; other site 1016998009860 Walker B; other site 1016998009861 D-loop; other site 1016998009862 H-loop/switch region; other site 1016998009863 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 1016998009864 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1016998009865 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1016998009866 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1016998009867 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1016998009868 putative active site [active] 1016998009869 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1016998009870 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 1016998009871 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1016998009872 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 1016998009873 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1016998009874 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 1016998009875 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 1016998009876 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 1016998009877 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1016998009878 Walker A/P-loop; other site 1016998009879 ATP binding site [chemical binding]; other site 1016998009880 Q-loop/lid; other site 1016998009881 ABC transporter signature motif; other site 1016998009882 Walker B; other site 1016998009883 D-loop; other site 1016998009884 H-loop/switch region; other site 1016998009885 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1016998009886 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1016998009887 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1016998009888 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1016998009889 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1016998009890 30S subunit binding site; other site 1016998009891 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1016998009892 active site 1016998009893 phosphorylation site [posttranslational modification] 1016998009894 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 1016998009895 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1016998009896 regulatory protein interface [polypeptide binding]; other site 1016998009897 active site 1016998009898 regulatory phosphorylation site [posttranslational modification]; other site 1016998009899 hypothetical protein; Provisional; Region: PRK10345 1016998009900 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1016998009901 Transglycosylase; Region: Transgly; cl17702 1016998009902 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 1016998009903 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 1016998009904 conserved cys residue [active] 1016998009905 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 1016998009906 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1016998009907 putative active site [active] 1016998009908 heme pocket [chemical binding]; other site 1016998009909 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1016998009910 dimer interface [polypeptide binding]; other site 1016998009911 phosphorylation site [posttranslational modification] 1016998009912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1016998009913 ATP binding site [chemical binding]; other site 1016998009914 Mg2+ binding site [ion binding]; other site 1016998009915 G-X-G motif; other site 1016998009916 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1016998009917 active site 1016998009918 phosphorylation site [posttranslational modification] 1016998009919 intermolecular recognition site; other site 1016998009920 dimerization interface [polypeptide binding]; other site 1016998009921 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1016998009922 putative binding surface; other site 1016998009923 active site 1016998009924 radical SAM protein, TIGR01212 family; Region: TIGR01212 1016998009925 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1016998009926 FeS/SAM binding site; other site 1016998009927 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1016998009928 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1016998009929 active site 1016998009930 dimer interface [polypeptide binding]; other site 1016998009931 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1016998009932 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1016998009933 active site 1016998009934 FMN binding site [chemical binding]; other site 1016998009935 substrate binding site [chemical binding]; other site 1016998009936 3Fe-4S cluster binding site [ion binding]; other site 1016998009937 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1016998009938 domain interface; other site 1016998009939 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 1016998009940 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1016998009941 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1016998009942 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 1016998009943 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 1016998009944 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 1016998009945 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1016998009946 Na binding site [ion binding]; other site 1016998009947 putative substrate binding site [chemical binding]; other site 1016998009948 cytosine deaminase; Provisional; Region: PRK09230 1016998009949 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1016998009950 active site 1016998009951 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1016998009952 N-acetylmannosamine kinase; Provisional; Region: PRK05082 1016998009953 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1016998009954 nucleotide binding site [chemical binding]; other site 1016998009955 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 1016998009956 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1016998009957 putative active site cavity [active] 1016998009958 putative sialic acid transporter; Provisional; Region: PRK03893 1016998009959 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998009960 putative substrate translocation pore; other site 1016998009961 N-acetylneuraminate lyase; Provisional; Region: PRK04147 1016998009962 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 1016998009963 inhibitor site; inhibition site 1016998009964 active site 1016998009965 dimer interface [polypeptide binding]; other site 1016998009966 catalytic residue [active] 1016998009967 transcriptional regulator NanR; Provisional; Region: PRK03837 1016998009968 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1016998009969 DNA-binding site [nucleotide binding]; DNA binding site 1016998009970 FCD domain; Region: FCD; pfam07729 1016998009971 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 1016998009972 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1016998009973 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 1016998009974 C-terminal domain interface [polypeptide binding]; other site 1016998009975 putative GSH binding site (G-site) [chemical binding]; other site 1016998009976 dimer interface [polypeptide binding]; other site 1016998009977 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1016998009978 dimer interface [polypeptide binding]; other site 1016998009979 N-terminal domain interface [polypeptide binding]; other site 1016998009980 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1016998009981 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1016998009982 23S rRNA interface [nucleotide binding]; other site 1016998009983 L3 interface [polypeptide binding]; other site 1016998009984 Predicted ATPase [General function prediction only]; Region: COG1485 1016998009985 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 1016998009986 hypothetical protein; Provisional; Region: PRK11677 1016998009987 serine endoprotease; Provisional; Region: PRK10139 1016998009988 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1016998009989 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1016998009990 protein binding site [polypeptide binding]; other site 1016998009991 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1016998009992 serine endoprotease; Provisional; Region: PRK10898 1016998009993 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1016998009994 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1016998009995 Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767 1016998009996 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 1016998009997 oxaloacetate decarboxylase; Provisional; Region: PRK14040 1016998009998 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1016998009999 active site 1016998010000 catalytic residues [active] 1016998010001 metal binding site [ion binding]; metal-binding site 1016998010002 homodimer binding site [polypeptide binding]; other site 1016998010003 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1016998010004 carboxyltransferase (CT) interaction site; other site 1016998010005 biotinylation site [posttranslational modification]; other site 1016998010006 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 1016998010007 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 1016998010008 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 1016998010009 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1016998010010 transmembrane helices; other site 1016998010011 Citrate transporter; Region: CitMHS; pfam03600 1016998010012 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1016998010013 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1016998010014 DNA-binding site [nucleotide binding]; DNA binding site 1016998010015 FCD domain; Region: FCD; pfam07729 1016998010016 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1016998010017 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1016998010018 DNA-binding site [nucleotide binding]; DNA binding site 1016998010019 malate dehydrogenase; Provisional; Region: PRK05086 1016998010020 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 1016998010021 NAD binding site [chemical binding]; other site 1016998010022 dimerization interface [polypeptide binding]; other site 1016998010023 Substrate binding site [chemical binding]; other site 1016998010024 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1016998010025 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1016998010026 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1016998010027 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1016998010028 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1016998010029 RNAase interaction site [polypeptide binding]; other site 1016998010030 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 1016998010031 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1016998010032 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 1016998010033 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1016998010034 HlyD family secretion protein; Region: HlyD_3; pfam13437 1016998010035 efflux system membrane protein; Provisional; Region: PRK11594 1016998010036 transcriptional regulator; Provisional; Region: PRK10632 1016998010037 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998010038 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1016998010039 putative effector binding pocket; other site 1016998010040 dimerization interface [polypeptide binding]; other site 1016998010041 protease TldD; Provisional; Region: tldD; PRK10735 1016998010042 hypothetical protein; Provisional; Region: PRK10899 1016998010043 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1016998010044 ribonuclease G; Provisional; Region: PRK11712 1016998010045 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1016998010046 homodimer interface [polypeptide binding]; other site 1016998010047 oligonucleotide binding site [chemical binding]; other site 1016998010048 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1016998010049 Maf-like protein; Region: Maf; pfam02545 1016998010050 active site 1016998010051 dimer interface [polypeptide binding]; other site 1016998010052 rod shape-determining protein MreD; Provisional; Region: PRK11060 1016998010053 rod shape-determining protein MreC; Region: mreC; TIGR00219 1016998010054 rod shape-determining protein MreC; Region: MreC; pfam04085 1016998010055 rod shape-determining protein MreB; Provisional; Region: PRK13927 1016998010056 MreB and similar proteins; Region: MreB_like; cd10225 1016998010057 nucleotide binding site [chemical binding]; other site 1016998010058 Mg binding site [ion binding]; other site 1016998010059 putative protofilament interaction site [polypeptide binding]; other site 1016998010060 RodZ interaction site [polypeptide binding]; other site 1016998010061 regulatory protein CsrD; Provisional; Region: PRK11059 1016998010062 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1016998010063 metal binding site [ion binding]; metal-binding site 1016998010064 active site 1016998010065 I-site; other site 1016998010066 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1016998010067 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1016998010068 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1016998010069 NADP binding site [chemical binding]; other site 1016998010070 dimer interface [polypeptide binding]; other site 1016998010071 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1016998010072 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 1016998010073 Moco binding site; other site 1016998010074 metal coordination site [ion binding]; other site 1016998010075 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1016998010076 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1016998010077 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1016998010078 carboxyltransferase (CT) interaction site; other site 1016998010079 biotinylation site [posttranslational modification]; other site 1016998010080 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1016998010081 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1016998010082 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1016998010083 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1016998010084 hypothetical protein; Provisional; Region: PRK10633 1016998010085 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 1016998010086 Na binding site [ion binding]; other site 1016998010087 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 1016998010088 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1016998010089 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 1016998010090 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1016998010091 FMN binding site [chemical binding]; other site 1016998010092 active site 1016998010093 catalytic residues [active] 1016998010094 substrate binding site [chemical binding]; other site 1016998010095 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 1016998010096 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 1016998010097 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1016998010098 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1016998010099 DNA methylase; Region: N6_N4_Mtase; pfam01555 1016998010100 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 1016998010101 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1016998010102 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1016998010103 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1016998010104 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1016998010105 metal binding site [ion binding]; metal-binding site 1016998010106 active site 1016998010107 I-site; other site 1016998010108 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1016998010109 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 1016998010110 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1016998010111 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1016998010112 HlyD family secretion protein; Region: HlyD; pfam00529 1016998010113 HlyD family secretion protein; Region: HlyD_3; pfam13437 1016998010114 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 1016998010115 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1016998010116 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1016998010117 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1016998010118 trimer interface [polypeptide binding]; other site 1016998010119 putative metal binding site [ion binding]; other site 1016998010120 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 1016998010121 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1016998010122 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1016998010123 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1016998010124 shikimate binding site; other site 1016998010125 NAD(P) binding site [chemical binding]; other site 1016998010126 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 1016998010127 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1016998010128 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1016998010129 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1016998010130 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1016998010131 hypothetical protein; Validated; Region: PRK03430 1016998010132 hypothetical protein; Provisional; Region: PRK10736 1016998010133 DNA protecting protein DprA; Region: dprA; TIGR00732 1016998010134 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1016998010135 active site 1016998010136 catalytic residues [active] 1016998010137 metal binding site [ion binding]; metal-binding site 1016998010138 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1016998010139 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1016998010140 putative active site [active] 1016998010141 substrate binding site [chemical binding]; other site 1016998010142 putative cosubstrate binding site; other site 1016998010143 catalytic site [active] 1016998010144 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1016998010145 substrate binding site [chemical binding]; other site 1016998010146 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1016998010147 putative RNA binding site [nucleotide binding]; other site 1016998010148 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1016998010149 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1016998010150 S-adenosylmethionine binding site [chemical binding]; other site 1016998010151 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1016998010152 TrkA-N domain; Region: TrkA_N; pfam02254 1016998010153 TrkA-C domain; Region: TrkA_C; pfam02080 1016998010154 TrkA-N domain; Region: TrkA_N; pfam02254 1016998010155 TrkA-C domain; Region: TrkA_C; pfam02080 1016998010156 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1016998010157 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1016998010158 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 1016998010159 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1016998010160 DNA binding residues [nucleotide binding] 1016998010161 dimer interface [polypeptide binding]; other site 1016998010162 metal binding site [ion binding]; metal-binding site 1016998010163 hypothetical protein; Provisional; Region: PRK10203 1016998010164 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1016998010165 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1016998010166 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1016998010167 alphaNTD homodimer interface [polypeptide binding]; other site 1016998010168 alphaNTD - beta interaction site [polypeptide binding]; other site 1016998010169 alphaNTD - beta' interaction site [polypeptide binding]; other site 1016998010170 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1016998010171 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1016998010172 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1016998010173 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1016998010174 RNA binding surface [nucleotide binding]; other site 1016998010175 30S ribosomal protein S11; Validated; Region: PRK05309 1016998010176 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1016998010177 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1016998010178 alpha operon ribosome binding site 1016998010179 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1016998010180 SecY translocase; Region: SecY; pfam00344 1016998010181 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1016998010182 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1016998010183 23S rRNA binding site [nucleotide binding]; other site 1016998010184 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1016998010185 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1016998010186 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1016998010187 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1016998010188 23S rRNA interface [nucleotide binding]; other site 1016998010189 5S rRNA interface [nucleotide binding]; other site 1016998010190 L27 interface [polypeptide binding]; other site 1016998010191 L5 interface [polypeptide binding]; other site 1016998010192 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1016998010193 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1016998010194 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1016998010195 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1016998010196 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1016998010197 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1016998010198 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1016998010199 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1016998010200 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1016998010201 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1016998010202 RNA binding site [nucleotide binding]; other site 1016998010203 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1016998010204 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1016998010205 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1016998010206 23S rRNA interface [nucleotide binding]; other site 1016998010207 putative translocon interaction site; other site 1016998010208 signal recognition particle (SRP54) interaction site; other site 1016998010209 L23 interface [polypeptide binding]; other site 1016998010210 trigger factor interaction site; other site 1016998010211 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1016998010212 23S rRNA interface [nucleotide binding]; other site 1016998010213 5S rRNA interface [nucleotide binding]; other site 1016998010214 putative antibiotic binding site [chemical binding]; other site 1016998010215 L25 interface [polypeptide binding]; other site 1016998010216 L27 interface [polypeptide binding]; other site 1016998010217 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1016998010218 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1016998010219 G-X-X-G motif; other site 1016998010220 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1016998010221 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1016998010222 protein-rRNA interface [nucleotide binding]; other site 1016998010223 putative translocon binding site; other site 1016998010224 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1016998010225 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1016998010226 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1016998010227 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1016998010228 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1016998010229 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1016998010230 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 1016998010231 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1016998010232 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1016998010233 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1016998010234 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1016998010235 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1016998010236 heme binding site [chemical binding]; other site 1016998010237 ferroxidase pore; other site 1016998010238 ferroxidase diiron center [ion binding]; other site 1016998010239 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 1016998010240 elongation factor Tu; Reviewed; Region: PRK00049 1016998010241 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1016998010242 G1 box; other site 1016998010243 GEF interaction site [polypeptide binding]; other site 1016998010244 GTP/Mg2+ binding site [chemical binding]; other site 1016998010245 Switch I region; other site 1016998010246 G2 box; other site 1016998010247 G3 box; other site 1016998010248 Switch II region; other site 1016998010249 G4 box; other site 1016998010250 G5 box; other site 1016998010251 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1016998010252 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1016998010253 Antibiotic Binding Site [chemical binding]; other site 1016998010254 elongation factor G; Reviewed; Region: PRK00007 1016998010255 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1016998010256 G1 box; other site 1016998010257 putative GEF interaction site [polypeptide binding]; other site 1016998010258 GTP/Mg2+ binding site [chemical binding]; other site 1016998010259 Switch I region; other site 1016998010260 G2 box; other site 1016998010261 G3 box; other site 1016998010262 Switch II region; other site 1016998010263 G4 box; other site 1016998010264 G5 box; other site 1016998010265 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1016998010266 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1016998010267 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1016998010268 30S ribosomal protein S7; Validated; Region: PRK05302 1016998010269 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1016998010270 S17 interaction site [polypeptide binding]; other site 1016998010271 S8 interaction site; other site 1016998010272 16S rRNA interaction site [nucleotide binding]; other site 1016998010273 streptomycin interaction site [chemical binding]; other site 1016998010274 23S rRNA interaction site [nucleotide binding]; other site 1016998010275 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1016998010276 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 1016998010277 sulfur relay protein TusC; Validated; Region: PRK00211 1016998010278 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 1016998010279 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1016998010280 YheO-like PAS domain; Region: PAS_6; pfam08348 1016998010281 HTH domain; Region: HTH_22; pfam13309 1016998010282 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 1016998010283 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1016998010284 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1016998010285 phi X174 lysis protein; Provisional; Region: PRK02793 1016998010286 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1016998010287 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1016998010288 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 1016998010289 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 1016998010290 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1016998010291 TrkA-N domain; Region: TrkA_N; pfam02254 1016998010292 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 1016998010293 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1016998010294 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1016998010295 Walker A/P-loop; other site 1016998010296 ATP binding site [chemical binding]; other site 1016998010297 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1016998010298 ABC transporter signature motif; other site 1016998010299 Walker B; other site 1016998010300 D-loop; other site 1016998010301 ABC transporter; Region: ABC_tran_2; pfam12848 1016998010302 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1016998010303 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998010304 putative monooxygenase; Provisional; Region: PRK11118 1016998010305 chromosomal replication initiation protein; Provisional; Region: PRK12422 1016998010306 putative hydrolase; Provisional; Region: PRK10985 1016998010307 hypothetical protein; Provisional; Region: PRK04966 1016998010308 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 1016998010309 active site 1016998010310 OsmC-like protein; Region: OsmC; cl00767 1016998010311 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1016998010312 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1016998010313 ligand binding site [chemical binding]; other site 1016998010314 flexible hinge region; other site 1016998010315 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1016998010316 putative switch regulator; other site 1016998010317 non-specific DNA interactions [nucleotide binding]; other site 1016998010318 DNA binding site [nucleotide binding] 1016998010319 sequence specific DNA binding site [nucleotide binding]; other site 1016998010320 putative cAMP binding site [chemical binding]; other site 1016998010321 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 1016998010322 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1016998010323 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1016998010324 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 1016998010325 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1016998010326 inhibitor-cofactor binding pocket; inhibition site 1016998010327 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998010328 catalytic residue [active] 1016998010329 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1016998010330 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1016998010331 glutamine binding [chemical binding]; other site 1016998010332 catalytic triad [active] 1016998010333 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 1016998010334 cell filamentation protein Fic; Provisional; Region: PRK10347 1016998010335 hypothetical protein; Provisional; Region: PRK10204 1016998010336 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 1016998010337 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1016998010338 substrate binding site [chemical binding]; other site 1016998010339 putative transporter; Provisional; Region: PRK03699 1016998010340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998010341 putative substrate translocation pore; other site 1016998010342 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1016998010343 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1016998010344 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1016998010345 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1016998010346 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1016998010347 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1016998010348 nitrite transporter NirC; Provisional; Region: PRK11562 1016998010349 siroheme synthase; Provisional; Region: cysG; PRK10637 1016998010350 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1016998010351 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1016998010352 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1016998010353 active site 1016998010354 SAM binding site [chemical binding]; other site 1016998010355 homodimer interface [polypeptide binding]; other site 1016998010356 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1016998010357 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 1016998010358 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1016998010359 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1016998010360 active site 1016998010361 HIGH motif; other site 1016998010362 dimer interface [polypeptide binding]; other site 1016998010363 KMSKS motif; other site 1016998010364 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1016998010365 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1016998010366 motif II; other site 1016998010367 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1016998010368 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1016998010369 substrate binding site [chemical binding]; other site 1016998010370 hexamer interface [polypeptide binding]; other site 1016998010371 metal binding site [ion binding]; metal-binding site 1016998010372 DNA adenine methylase; Provisional; Region: PRK10904 1016998010373 cell division protein DamX; Validated; Region: PRK10905 1016998010374 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 1016998010375 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1016998010376 active site 1016998010377 dimer interface [polypeptide binding]; other site 1016998010378 metal binding site [ion binding]; metal-binding site 1016998010379 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 1016998010380 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1016998010381 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1016998010382 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 1016998010383 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 1016998010384 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1016998010385 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 1016998010386 Transglycosylase; Region: Transgly; pfam00912 1016998010387 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1016998010388 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1016998010389 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1016998010390 ADP-ribose binding site [chemical binding]; other site 1016998010391 dimer interface [polypeptide binding]; other site 1016998010392 active site 1016998010393 nudix motif; other site 1016998010394 metal binding site [ion binding]; metal-binding site 1016998010395 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 1016998010396 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1016998010397 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1016998010398 motif II; other site 1016998010399 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1016998010400 RNA binding surface [nucleotide binding]; other site 1016998010401 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1016998010402 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1016998010403 dimerization interface [polypeptide binding]; other site 1016998010404 domain crossover interface; other site 1016998010405 redox-dependent activation switch; other site 1016998010406 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 1016998010407 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1016998010408 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1016998010409 active site 1016998010410 substrate-binding site [chemical binding]; other site 1016998010411 metal-binding site [ion binding] 1016998010412 ATP binding site [chemical binding]; other site 1016998010413 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1016998010414 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1016998010415 dimerization interface [polypeptide binding]; other site 1016998010416 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1016998010417 dimer interface [polypeptide binding]; other site 1016998010418 phosphorylation site [posttranslational modification] 1016998010419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1016998010420 ATP binding site [chemical binding]; other site 1016998010421 G-X-G motif; other site 1016998010422 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1016998010423 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1016998010424 active site 1016998010425 phosphorylation site [posttranslational modification] 1016998010426 intermolecular recognition site; other site 1016998010427 dimerization interface [polypeptide binding]; other site 1016998010428 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1016998010429 DNA binding site [nucleotide binding] 1016998010430 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1016998010431 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1016998010432 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1016998010433 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1016998010434 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1016998010435 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1016998010436 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1016998010437 RNA binding site [nucleotide binding]; other site 1016998010438 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 1016998010439 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 1016998010440 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1016998010441 G1 box; other site 1016998010442 GTP/Mg2+ binding site [chemical binding]; other site 1016998010443 Switch I region; other site 1016998010444 G2 box; other site 1016998010445 G3 box; other site 1016998010446 Switch II region; other site 1016998010447 G4 box; other site 1016998010448 G5 box; other site 1016998010449 Nucleoside recognition; Region: Gate; pfam07670 1016998010450 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1016998010451 Nucleoside recognition; Region: Gate; pfam07670 1016998010452 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 1016998010453 hypothetical protein; Provisional; Region: PRK09956 1016998010454 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1016998010455 carboxylesterase BioH; Provisional; Region: PRK10349 1016998010456 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1016998010457 DNA utilization protein GntX; Provisional; Region: PRK11595 1016998010458 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1016998010459 active site 1016998010460 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 1016998010461 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1016998010462 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1016998010463 high-affinity gluconate transporter; Provisional; Region: PRK14984 1016998010464 gluconate transporter; Region: gntP; TIGR00791 1016998010465 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1016998010466 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 1016998010467 maltodextrin phosphorylase; Provisional; Region: PRK14985 1016998010468 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1016998010469 homodimer interface [polypeptide binding]; other site 1016998010470 active site pocket [active] 1016998010471 transcriptional regulator MalT; Provisional; Region: PRK04841 1016998010472 AAA ATPase domain; Region: AAA_16; pfam13191 1016998010473 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1016998010474 DNA binding residues [nucleotide binding] 1016998010475 dimerization interface [polypeptide binding]; other site 1016998010476 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 1016998010477 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1016998010478 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1016998010479 intramembrane serine protease GlpG; Provisional; Region: PRK10907 1016998010480 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 1016998010481 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1016998010482 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1016998010483 active site residue [active] 1016998010484 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1016998010485 hypothetical protein; Provisional; Region: PRK09781 1016998010486 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 1016998010487 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1016998010488 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1016998010489 dimer interface [polypeptide binding]; other site 1016998010490 active site 1016998010491 metal binding site [ion binding]; metal-binding site 1016998010492 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998010493 D-galactonate transporter; Region: 2A0114; TIGR00893 1016998010494 putative substrate translocation pore; other site 1016998010495 Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism / Carbohydrate transport and metabolism]; Region: IlvD; COG0129 1016998010496 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1016998010497 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1016998010498 inhibitor site; inhibition site 1016998010499 active site 1016998010500 dimer interface [polypeptide binding]; other site 1016998010501 catalytic residue [active] 1016998010502 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1016998010503 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1016998010504 Bacterial transcriptional regulator; Region: IclR; pfam01614 1016998010505 glycogen phosphorylase; Provisional; Region: PRK14986 1016998010506 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1016998010507 homodimer interface [polypeptide binding]; other site 1016998010508 active site pocket [active] 1016998010509 glycogen synthase; Provisional; Region: glgA; PRK00654 1016998010510 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1016998010511 ADP-binding pocket [chemical binding]; other site 1016998010512 homodimer interface [polypeptide binding]; other site 1016998010513 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 1016998010514 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1016998010515 ligand binding site; other site 1016998010516 oligomer interface; other site 1016998010517 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1016998010518 dimer interface [polypeptide binding]; other site 1016998010519 N-terminal domain interface [polypeptide binding]; other site 1016998010520 sulfate 1 binding site; other site 1016998010521 glycogen debranching enzyme; Provisional; Region: PRK03705 1016998010522 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1016998010523 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1016998010524 active site 1016998010525 catalytic site [active] 1016998010526 glycogen branching enzyme; Provisional; Region: PRK05402 1016998010527 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1016998010528 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1016998010529 active site 1016998010530 catalytic site [active] 1016998010531 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1016998010532 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1016998010533 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1016998010534 low affinity gluconate transporter; Provisional; Region: PRK10472 1016998010535 gluconate transporter; Region: gntP; TIGR00791 1016998010536 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1016998010537 ATP-binding site [chemical binding]; other site 1016998010538 Gluconate-6-phosphate binding site [chemical binding]; other site 1016998010539 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 1016998010540 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1016998010541 DNA binding site [nucleotide binding] 1016998010542 domain linker motif; other site 1016998010543 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1016998010544 putative ligand binding site [chemical binding]; other site 1016998010545 putative dimerization interface [polypeptide binding]; other site 1016998010546 Pirin-related protein [General function prediction only]; Region: COG1741 1016998010547 Pirin; Region: Pirin; pfam02678 1016998010548 putative oxidoreductase; Provisional; Region: PRK10206 1016998010549 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1016998010550 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1016998010551 putative acetyltransferase YhhY; Provisional; Region: PRK10140 1016998010552 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1016998010553 Coenzyme A binding pocket [chemical binding]; other site 1016998010554 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1016998010555 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1016998010556 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1016998010557 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1016998010558 substrate binding site [chemical binding]; other site 1016998010559 dimer interface [polypeptide binding]; other site 1016998010560 ATP binding site [chemical binding]; other site 1016998010561 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1016998010562 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1016998010563 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1016998010564 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1016998010565 active site 1016998010566 substrate binding pocket [chemical binding]; other site 1016998010567 homodimer interaction site [polypeptide binding]; other site 1016998010568 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 1016998010569 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1016998010570 hypothetical protein; Provisional; Region: PRK10350 1016998010571 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 1016998010572 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1016998010573 putative active site [active] 1016998010574 catalytic site [active] 1016998010575 putative metal binding site [ion binding]; other site 1016998010576 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1016998010577 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1016998010578 Walker A/P-loop; other site 1016998010579 ATP binding site [chemical binding]; other site 1016998010580 Q-loop/lid; other site 1016998010581 ABC transporter signature motif; other site 1016998010582 Walker B; other site 1016998010583 D-loop; other site 1016998010584 H-loop/switch region; other site 1016998010585 TOBE domain; Region: TOBE_2; pfam08402 1016998010586 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1016998010587 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998010588 dimer interface [polypeptide binding]; other site 1016998010589 conserved gate region; other site 1016998010590 ABC-ATPase subunit interface; other site 1016998010591 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1016998010592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998010593 dimer interface [polypeptide binding]; other site 1016998010594 conserved gate region; other site 1016998010595 putative PBP binding loops; other site 1016998010596 ABC-ATPase subunit interface; other site 1016998010597 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 1016998010598 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1016998010599 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 1016998010600 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1016998010601 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 1016998010602 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1016998010603 Walker A/P-loop; other site 1016998010604 ATP binding site [chemical binding]; other site 1016998010605 Q-loop/lid; other site 1016998010606 ABC transporter signature motif; other site 1016998010607 Walker B; other site 1016998010608 D-loop; other site 1016998010609 H-loop/switch region; other site 1016998010610 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1016998010611 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1016998010612 Walker A/P-loop; other site 1016998010613 ATP binding site [chemical binding]; other site 1016998010614 Q-loop/lid; other site 1016998010615 ABC transporter signature motif; other site 1016998010616 Walker B; other site 1016998010617 D-loop; other site 1016998010618 H-loop/switch region; other site 1016998010619 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1016998010620 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1016998010621 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1016998010622 TM-ABC transporter signature motif; other site 1016998010623 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1016998010624 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1016998010625 TM-ABC transporter signature motif; other site 1016998010626 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1016998010627 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1016998010628 dimerization interface [polypeptide binding]; other site 1016998010629 ligand binding site [chemical binding]; other site 1016998010630 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 1016998010631 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1016998010632 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1016998010633 dimerization interface [polypeptide binding]; other site 1016998010634 ligand binding site [chemical binding]; other site 1016998010635 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1016998010636 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1016998010637 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1016998010638 DNA binding residues [nucleotide binding] 1016998010639 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 1016998010640 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1016998010641 cell division protein FtsE; Provisional; Region: PRK10908 1016998010642 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1016998010643 Walker A/P-loop; other site 1016998010644 ATP binding site [chemical binding]; other site 1016998010645 Q-loop/lid; other site 1016998010646 ABC transporter signature motif; other site 1016998010647 Walker B; other site 1016998010648 D-loop; other site 1016998010649 H-loop/switch region; other site 1016998010650 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1016998010651 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1016998010652 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1016998010653 P loop; other site 1016998010654 GTP binding site [chemical binding]; other site 1016998010655 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1016998010656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1016998010657 S-adenosylmethionine binding site [chemical binding]; other site 1016998010658 hypothetical protein; Provisional; Region: PRK10910 1016998010659 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 1016998010660 Predicted membrane protein [Function unknown]; Region: COG3714 1016998010661 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 1016998010662 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1016998010663 metal-binding site [ion binding] 1016998010664 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1016998010665 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1016998010666 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1016998010667 dimer interface [polypeptide binding]; other site 1016998010668 ligand binding site [chemical binding]; other site 1016998010669 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1016998010670 dimerization interface [polypeptide binding]; other site 1016998010671 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1016998010672 dimer interface [polypeptide binding]; other site 1016998010673 putative CheW interface [polypeptide binding]; other site 1016998010674 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 1016998010675 CPxP motif; other site 1016998010676 hypothetical protein; Provisional; Region: PRK11212 1016998010677 hypothetical protein; Provisional; Region: PRK11615 1016998010678 major facilitator superfamily transporter; Provisional; Region: PRK05122 1016998010679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998010680 putative substrate translocation pore; other site 1016998010681 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1016998010682 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1016998010683 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 1016998010684 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1016998010685 nickel responsive regulator; Provisional; Region: PRK02967 1016998010686 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 1016998010687 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1016998010688 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1016998010689 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1016998010690 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1016998010691 Walker A/P-loop; other site 1016998010692 ATP binding site [chemical binding]; other site 1016998010693 Q-loop/lid; other site 1016998010694 ABC transporter signature motif; other site 1016998010695 Walker B; other site 1016998010696 D-loop; other site 1016998010697 H-loop/switch region; other site 1016998010698 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1016998010699 Walker A/P-loop; other site 1016998010700 ATP binding site [chemical binding]; other site 1016998010701 Q-loop/lid; other site 1016998010702 ABC transporter signature motif; other site 1016998010703 Walker B; other site 1016998010704 D-loop; other site 1016998010705 H-loop/switch region; other site 1016998010706 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1016998010707 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1016998010708 HlyD family secretion protein; Region: HlyD; pfam00529 1016998010709 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1016998010710 HlyD family secretion protein; Region: HlyD_3; pfam13437 1016998010711 Predicted flavoproteins [General function prediction only]; Region: COG2081 1016998010712 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1016998010713 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1016998010714 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1016998010715 universal stress protein UspB; Provisional; Region: PRK04960 1016998010716 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1016998010717 Ligand Binding Site [chemical binding]; other site 1016998010718 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 1016998010719 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998010720 putative substrate translocation pore; other site 1016998010721 POT family; Region: PTR2; pfam00854 1016998010722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1016998010723 S-adenosylmethionine binding site [chemical binding]; other site 1016998010724 oligopeptidase A; Provisional; Region: PRK10911 1016998010725 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1016998010726 active site 1016998010727 Zn binding site [ion binding]; other site 1016998010728 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 1016998010729 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1016998010730 active site 1016998010731 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1016998010732 glutathione reductase; Validated; Region: PRK06116 1016998010733 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1016998010734 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1016998010735 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1016998010736 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1016998010737 active site 1016998010738 homodimer interface [polypeptide binding]; other site 1016998010739 homotetramer interface [polypeptide binding]; other site 1016998010740 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1016998010741 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1016998010742 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 1016998010743 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1016998010744 substrate binding site [chemical binding]; other site 1016998010745 ATP binding site [chemical binding]; other site 1016998010746 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1016998010747 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1016998010748 putative active site [active] 1016998010749 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1016998010750 dimer interface [polypeptide binding]; other site 1016998010751 active site 1016998010752 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1016998010753 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1016998010754 DNA-binding site [nucleotide binding]; DNA binding site 1016998010755 UTRA domain; Region: UTRA; pfam07702 1016998010756 trehalase; Provisional; Region: treF; PRK13270 1016998010757 Trehalase; Region: Trehalase; pfam01204 1016998010758 Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772 1016998010759 catalytic residue [active] 1016998010760 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1016998010761 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1016998010762 active site 1016998010763 phosphorylation site [posttranslational modification] 1016998010764 dimerization interface [polypeptide binding]; other site 1016998010765 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1016998010766 DNA binding residues [nucleotide binding] 1016998010767 dimerization interface [polypeptide binding]; other site 1016998010768 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1016998010769 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998010770 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1016998010771 putative effector binding pocket; other site 1016998010772 putative dimerization interface [polypeptide binding]; other site 1016998010773 inner membrane protein YhjD; Region: TIGR00766 1016998010774 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998010775 metabolite-proton symporter; Region: 2A0106; TIGR00883 1016998010776 putative substrate translocation pore; other site 1016998010777 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1016998010778 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1016998010779 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1016998010780 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1016998010781 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1016998010782 substrate binding site [chemical binding]; other site 1016998010783 ATP binding site [chemical binding]; other site 1016998010784 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1016998010785 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1016998010786 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1016998010787 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1016998010788 putative diguanylate cyclase; Provisional; Region: PRK13561 1016998010789 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1016998010790 metal binding site [ion binding]; metal-binding site 1016998010791 active site 1016998010792 I-site; other site 1016998010793 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1016998010794 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 1016998010795 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1016998010796 TPR motif; other site 1016998010797 binding surface 1016998010798 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1016998010799 TPR motif; other site 1016998010800 binding surface 1016998010801 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1016998010802 binding surface 1016998010803 TPR motif; other site 1016998010804 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 1016998010805 endo-1,4-D-glucanase; Provisional; Region: PRK11097 1016998010806 cellulose synthase regulator protein; Provisional; Region: PRK11114 1016998010807 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 1016998010808 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1016998010809 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1016998010810 DXD motif; other site 1016998010811 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1016998010812 PilZ domain; Region: PilZ; pfam07238 1016998010813 cell division protein; Provisional; Region: PRK10037 1016998010814 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 1016998010815 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 1016998010816 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 1016998010817 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 1016998010818 cellulose synthase operon protein YhjU; Region: cellulose_yhjU; TIGR03368 1016998010819 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 1016998010820 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1016998010821 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1016998010822 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1016998010823 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1016998010824 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1016998010825 Walker A/P-loop; other site 1016998010826 ATP binding site [chemical binding]; other site 1016998010827 Q-loop/lid; other site 1016998010828 ABC transporter signature motif; other site 1016998010829 Walker B; other site 1016998010830 D-loop; other site 1016998010831 H-loop/switch region; other site 1016998010832 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1016998010833 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 1016998010834 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1016998010835 Walker A/P-loop; other site 1016998010836 ATP binding site [chemical binding]; other site 1016998010837 Q-loop/lid; other site 1016998010838 ABC transporter signature motif; other site 1016998010839 Walker B; other site 1016998010840 D-loop; other site 1016998010841 H-loop/switch region; other site 1016998010842 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1016998010843 dipeptide transporter; Provisional; Region: PRK10913 1016998010844 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1016998010845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998010846 dimer interface [polypeptide binding]; other site 1016998010847 conserved gate region; other site 1016998010848 putative PBP binding loops; other site 1016998010849 ABC-ATPase subunit interface; other site 1016998010850 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1016998010851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998010852 dimer interface [polypeptide binding]; other site 1016998010853 conserved gate region; other site 1016998010854 putative PBP binding loops; other site 1016998010855 ABC-ATPase subunit interface; other site 1016998010856 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1016998010857 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1016998010858 peptide binding site [polypeptide binding]; other site 1016998010859 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1016998010860 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 1016998010861 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1016998010862 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1016998010863 DNA binding site [nucleotide binding] 1016998010864 domain linker motif; other site 1016998010865 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_8; cd06287 1016998010866 putative dimerization interface [polypeptide binding]; other site 1016998010867 putative ligand binding site [chemical binding]; other site 1016998010868 phosphoethanolamine transferase; Provisional; Region: PRK11560 1016998010869 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1016998010870 Sulfatase; Region: Sulfatase; pfam00884 1016998010871 long polar fimbrial protein LpfE; Provisional; Region: PRK15205 1016998010872 long polar fimbrial protein LpfD; Provisional; Region: PRK15206 1016998010873 long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208 1016998010874 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1016998010875 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1016998010876 long polar fimbrial protein LpfA; Provisional; Region: PRK15209 1016998010877 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 1016998010878 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 1016998010879 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1016998010880 Coenzyme A binding pocket [chemical binding]; other site 1016998010881 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1016998010882 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1016998010883 molybdopterin cofactor binding site [chemical binding]; other site 1016998010884 substrate binding site [chemical binding]; other site 1016998010885 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1016998010886 molybdopterin cofactor binding site; other site 1016998010887 putative outer membrane lipoprotein; Provisional; Region: PRK10510 1016998010888 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1016998010889 ligand binding site [chemical binding]; other site 1016998010890 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1016998010891 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1016998010892 dimerization interface [polypeptide binding]; other site 1016998010893 ligand binding site [chemical binding]; other site 1016998010894 NADP binding site [chemical binding]; other site 1016998010895 catalytic site [active] 1016998010896 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 1016998010897 Predicted transcriptional regulator [Transcription]; Region: COG2944 1016998010898 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1016998010899 salt bridge; other site 1016998010900 non-specific DNA binding site [nucleotide binding]; other site 1016998010901 sequence-specific DNA binding site [nucleotide binding]; other site 1016998010902 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1016998010903 DNA-binding site [nucleotide binding]; DNA binding site 1016998010904 RNA-binding motif; other site 1016998010905 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1016998010906 DALR anticodon binding domain; Region: DALR_1; pfam05746 1016998010907 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 1016998010908 dimer interface [polypeptide binding]; other site 1016998010909 motif 2; other site 1016998010910 active site 1016998010911 motif 3; other site 1016998010912 YsaB-like lipoprotein; Region: YsaB; pfam13983 1016998010913 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1016998010914 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1016998010915 Predicted membrane protein [Function unknown]; Region: COG4682 1016998010916 yiaA/B two helix domain; Region: YiaAB; cl01759 1016998010917 yiaA/B two helix domain; Region: YiaAB; cl01759 1016998010918 xylulokinase; Provisional; Region: PRK15027 1016998010919 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1016998010920 N- and C-terminal domain interface [polypeptide binding]; other site 1016998010921 active site 1016998010922 MgATP binding site [chemical binding]; other site 1016998010923 catalytic site [active] 1016998010924 metal binding site [ion binding]; metal-binding site 1016998010925 xylulose binding site [chemical binding]; other site 1016998010926 homodimer interface [polypeptide binding]; other site 1016998010927 xylose isomerase; Provisional; Region: PRK05474 1016998010928 xylose isomerase; Region: xylose_isom_A; TIGR02630 1016998010929 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 1016998010930 putative dimerization interface [polypeptide binding]; other site 1016998010931 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1016998010932 putative ligand binding site [chemical binding]; other site 1016998010933 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1016998010934 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1016998010935 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1016998010936 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 1016998010937 hypothetical protein; Provisional; Region: PRK10356 1016998010938 alpha-amylase; Reviewed; Region: malS; PRK09505 1016998010939 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1016998010940 active site 1016998010941 catalytic site [active] 1016998010942 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 1016998010943 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1016998010944 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998010945 homodimer interface [polypeptide binding]; other site 1016998010946 catalytic residue [active] 1016998010947 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 1016998010948 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1016998010949 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1016998010950 Bacterial transcriptional regulator; Region: IclR; pfam01614 1016998010951 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 1016998010952 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1016998010953 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 1016998010954 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 1016998010955 DctM-like transporters; Region: DctM; pfam06808 1016998010956 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1016998010957 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 1016998010958 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1016998010959 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 1016998010960 putative N- and C-terminal domain interface [polypeptide binding]; other site 1016998010961 putative active site [active] 1016998010962 MgATP binding site [chemical binding]; other site 1016998010963 catalytic site [active] 1016998010964 metal binding site [ion binding]; metal-binding site 1016998010965 putative xylulose binding site [chemical binding]; other site 1016998010966 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1016998010967 active site 1016998010968 dimer interface [polypeptide binding]; other site 1016998010969 magnesium binding site [ion binding]; other site 1016998010970 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 1016998010971 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1016998010972 AP (apurinic/apyrimidinic) site pocket; other site 1016998010973 DNA interaction; other site 1016998010974 Metal-binding active site; metal-binding site 1016998010975 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1016998010976 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1016998010977 intersubunit interface [polypeptide binding]; other site 1016998010978 active site 1016998010979 Zn2+ binding site [ion binding]; other site 1016998010980 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1016998010981 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1016998010982 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1016998010983 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1016998010984 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1016998010985 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1016998010986 NAD(P) binding site [chemical binding]; other site 1016998010987 catalytic residues [active] 1016998010988 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1016998010989 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1016998010990 nucleotide binding site [chemical binding]; other site 1016998010991 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 1016998010992 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1016998010993 G1 box; other site 1016998010994 putative GEF interaction site [polypeptide binding]; other site 1016998010995 GTP/Mg2+ binding site [chemical binding]; other site 1016998010996 Switch I region; other site 1016998010997 G2 box; other site 1016998010998 G3 box; other site 1016998010999 Switch II region; other site 1016998011000 G4 box; other site 1016998011001 G5 box; other site 1016998011002 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1016998011003 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 1016998011004 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 1016998011005 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1016998011006 selenocysteine synthase; Provisional; Region: PRK04311 1016998011007 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 1016998011008 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 1016998011009 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1016998011010 catalytic residue [active] 1016998011011 putative glutathione S-transferase; Provisional; Region: PRK10357 1016998011012 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 1016998011013 putative C-terminal domain interface [polypeptide binding]; other site 1016998011014 putative GSH binding site (G-site) [chemical binding]; other site 1016998011015 putative dimer interface [polypeptide binding]; other site 1016998011016 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1016998011017 dimer interface [polypeptide binding]; other site 1016998011018 N-terminal domain interface [polypeptide binding]; other site 1016998011019 putative substrate binding pocket (H-site) [chemical binding]; other site 1016998011020 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 1016998011021 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1016998011022 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1016998011023 active site 1016998011024 P-loop; other site 1016998011025 phosphorylation site [posttranslational modification] 1016998011026 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1016998011027 active site 1016998011028 phosphorylation site [posttranslational modification] 1016998011029 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1016998011030 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1016998011031 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1016998011032 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 1016998011033 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 1016998011034 hypothetical protein; Provisional; Region: PRK11020 1016998011035 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 1016998011036 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 1016998011037 trimer interface [polypeptide binding]; other site 1016998011038 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 1016998011039 Haemagglutinin; Region: HIM; pfam05662 1016998011040 Haemagglutinin; Region: HIM; pfam05662 1016998011041 YadA-like C-terminal region; Region: YadA; pfam03895 1016998011042 L-lactate permease; Provisional; Region: PRK10420 1016998011043 glycolate transporter; Provisional; Region: PRK09695 1016998011044 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 1016998011045 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1016998011046 DNA-binding site [nucleotide binding]; DNA binding site 1016998011047 FCD domain; Region: FCD; pfam07729 1016998011048 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 1016998011049 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1016998011050 active site 1016998011051 substrate binding site [chemical binding]; other site 1016998011052 FMN binding site [chemical binding]; other site 1016998011053 putative catalytic residues [active] 1016998011054 putative rRNA methylase; Provisional; Region: PRK10358 1016998011055 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1016998011056 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1016998011057 DNA binding site [nucleotide binding] 1016998011058 domain linker motif; other site 1016998011059 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1016998011060 putative dimerization interface [polypeptide binding]; other site 1016998011061 putative ligand binding site [chemical binding]; other site 1016998011062 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1016998011063 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1016998011064 active site pocket [active] 1016998011065 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998011066 D-galactonate transporter; Region: 2A0114; TIGR00893 1016998011067 putative substrate translocation pore; other site 1016998011068 serine acetyltransferase; Provisional; Region: cysE; PRK11132 1016998011069 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 1016998011070 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1016998011071 trimer interface [polypeptide binding]; other site 1016998011072 active site 1016998011073 substrate binding site [chemical binding]; other site 1016998011074 CoA binding site [chemical binding]; other site 1016998011075 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1016998011076 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1016998011077 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1016998011078 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 1016998011079 SecA binding site; other site 1016998011080 Preprotein binding site; other site 1016998011081 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1016998011082 GSH binding site [chemical binding]; other site 1016998011083 catalytic residues [active] 1016998011084 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1016998011085 active site residue [active] 1016998011086 phosphoglyceromutase; Provisional; Region: PRK05434 1016998011087 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 1016998011088 AmiB activator; Provisional; Region: PRK11637 1016998011089 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1016998011090 Peptidase family M23; Region: Peptidase_M23; pfam01551 1016998011091 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1016998011092 NodB motif; other site 1016998011093 putative active site [active] 1016998011094 putative catalytic site [active] 1016998011095 Zn binding site [ion binding]; other site 1016998011096 putative glycosyl transferase; Provisional; Region: PRK10073 1016998011097 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1016998011098 active site 1016998011099 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1016998011100 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1016998011101 NAD(P) binding site [chemical binding]; other site 1016998011102 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1016998011103 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1016998011104 substrate-cofactor binding pocket; other site 1016998011105 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998011106 catalytic residue [active] 1016998011107 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 1016998011108 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 1016998011109 NADP binding site [chemical binding]; other site 1016998011110 homopentamer interface [polypeptide binding]; other site 1016998011111 substrate binding site [chemical binding]; other site 1016998011112 active site 1016998011113 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1016998011114 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1016998011115 putative active site [active] 1016998011116 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1016998011117 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 1016998011118 putative active site [active] 1016998011119 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1016998011120 O-antigen ligase RfaL; Provisional; Region: PRK15487 1016998011121 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 1016998011122 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1016998011123 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 1016998011124 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176 1016998011125 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 1016998011126 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1016998011127 Ligand binding site; other site 1016998011128 metal-binding site 1016998011129 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 1016998011130 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 1016998011131 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1016998011132 Ligand binding site; other site 1016998011133 metal-binding site 1016998011134 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 1016998011135 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 1016998011136 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1016998011137 putative ADP-binding pocket [chemical binding]; other site 1016998011138 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1016998011139 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 1016998011140 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1016998011141 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1016998011142 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 1016998011143 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1016998011144 putative active site [active] 1016998011145 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 1016998011146 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1016998011147 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1016998011148 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1016998011149 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1016998011150 active site 1016998011151 (T/H)XGH motif; other site 1016998011152 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1016998011153 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1016998011154 DNA binding site [nucleotide binding] 1016998011155 catalytic residue [active] 1016998011156 H2TH interface [polypeptide binding]; other site 1016998011157 putative catalytic residues [active] 1016998011158 turnover-facilitating residue; other site 1016998011159 intercalation triad [nucleotide binding]; other site 1016998011160 8OG recognition residue [nucleotide binding]; other site 1016998011161 putative reading head residues; other site 1016998011162 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1016998011163 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1016998011164 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1016998011165 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1016998011166 hypothetical protein; Reviewed; Region: PRK00024 1016998011167 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1016998011168 MPN+ (JAMM) motif; other site 1016998011169 Zinc-binding site [ion binding]; other site 1016998011170 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1016998011171 Flavoprotein; Region: Flavoprotein; pfam02441 1016998011172 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1016998011173 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1016998011174 trimer interface [polypeptide binding]; other site 1016998011175 active site 1016998011176 division inhibitor protein; Provisional; Region: slmA; PRK09480 1016998011177 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1016998011178 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1016998011179 active site 1016998011180 ribonuclease PH; Reviewed; Region: rph; PRK00173 1016998011181 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1016998011182 oligomer interface [polypeptide binding]; other site 1016998011183 hypothetical protein; Provisional; Region: PRK11820 1016998011184 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1016998011185 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1016998011186 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1016998011187 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998011188 dimerization interface [polypeptide binding]; other site 1016998011189 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1016998011190 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1016998011191 Predicted membrane protein [Function unknown]; Region: COG2860 1016998011192 UPF0126 domain; Region: UPF0126; pfam03458 1016998011193 UPF0126 domain; Region: UPF0126; pfam03458 1016998011194 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 1016998011195 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 1016998011196 nucleotide binding pocket [chemical binding]; other site 1016998011197 K-X-D-G motif; other site 1016998011198 catalytic site [active] 1016998011199 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1016998011200 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1016998011201 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1016998011202 catalytic site [active] 1016998011203 G-X2-G-X-G-K; other site 1016998011204 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1016998011205 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 1016998011206 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1016998011207 Zn2+ binding site [ion binding]; other site 1016998011208 Mg2+ binding site [ion binding]; other site 1016998011209 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1016998011210 synthetase active site [active] 1016998011211 NTP binding site [chemical binding]; other site 1016998011212 metal binding site [ion binding]; metal-binding site 1016998011213 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1016998011214 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1016998011215 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 1016998011216 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1016998011217 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 1016998011218 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1016998011219 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1016998011220 generic binding surface II; other site 1016998011221 ssDNA binding site; other site 1016998011222 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1016998011223 ATP binding site [chemical binding]; other site 1016998011224 putative Mg++ binding site [ion binding]; other site 1016998011225 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1016998011226 nucleotide binding region [chemical binding]; other site 1016998011227 ATP-binding site [chemical binding]; other site 1016998011228 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 1016998011229 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1016998011230 AsmA family; Region: AsmA; pfam05170 1016998011231 putative alpha-glucosidase; Provisional; Region: PRK10658 1016998011232 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1016998011233 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 1016998011234 active site 1016998011235 homotrimer interface [polypeptide binding]; other site 1016998011236 catalytic site [active] 1016998011237 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 1016998011238 putative transporter; Provisional; Region: PRK11462 1016998011239 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1016998011240 Methyltransferase domain; Region: Methyltransf_27; pfam13708 1016998011241 Virulence protein [General function prediction only]; Region: COG3943 1016998011242 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 1016998011243 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1016998011244 Transposase; Region: HTH_Tnp_1; pfam01527 1016998011245 autotransport protein MisL; Provisional; Region: PRK15313 1016998011246 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1016998011247 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1016998011248 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1016998011249 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1016998011250 DNA binding site [nucleotide binding] 1016998011251 Isochorismatase family; Region: Isochorismatase; pfam00857 1016998011252 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1016998011253 catalytic triad [active] 1016998011254 dimer interface [polypeptide binding]; other site 1016998011255 conserved cis-peptide bond; other site 1016998011256 magnesium-transporting ATPase; Provisional; Region: PRK15122 1016998011257 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1016998011258 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1016998011259 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1016998011260 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1016998011261 motif II; other site 1016998011262 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1016998011263 magnesium transport protein MgtC; Provisional; Region: PRK15385 1016998011264 MgtC family; Region: MgtC; pfam02308 1016998011265 EamA-like transporter family; Region: EamA; pfam00892 1016998011266 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1016998011267 EamA-like transporter family; Region: EamA; pfam00892 1016998011268 hypothetical protein; Provisional; Region: PRK09956 1016998011269 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1016998011270 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 1016998011271 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 1016998011272 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 1016998011273 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1016998011274 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 1016998011275 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1016998011276 active site 1016998011277 phosphorylation site [posttranslational modification] 1016998011278 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1016998011279 active pocket/dimerization site; other site 1016998011280 active site 1016998011281 phosphorylation site [posttranslational modification] 1016998011282 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1016998011283 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1016998011284 Walker A motif; other site 1016998011285 ATP binding site [chemical binding]; other site 1016998011286 Walker B motif; other site 1016998011287 arginine finger; other site 1016998011288 Transcriptional antiterminator [Transcription]; Region: COG3933 1016998011289 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1016998011290 active site 1016998011291 active pocket/dimerization site; other site 1016998011292 phosphorylation site [posttranslational modification] 1016998011293 PRD domain; Region: PRD; pfam00874 1016998011294 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1016998011295 beta-galactosidase; Region: BGL; TIGR03356 1016998011296 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 1016998011297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998011298 putative substrate translocation pore; other site 1016998011299 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737 1016998011300 Predicted transcriptional regulator [Transcription]; Region: COG2944 1016998011301 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1016998011302 non-specific DNA binding site [nucleotide binding]; other site 1016998011303 salt bridge; other site 1016998011304 sequence-specific DNA binding site [nucleotide binding]; other site 1016998011305 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1016998011306 dimerization domain swap beta strand [polypeptide binding]; other site 1016998011307 regulatory protein interface [polypeptide binding]; other site 1016998011308 active site 1016998011309 regulatory phosphorylation site [posttranslational modification]; other site 1016998011310 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1016998011311 intersubunit interface [polypeptide binding]; other site 1016998011312 active site 1016998011313 zinc binding site [ion binding]; other site 1016998011314 Na+ binding site [ion binding]; other site 1016998011315 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1016998011316 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 1016998011317 putative N- and C-terminal domain interface [polypeptide binding]; other site 1016998011318 putative active site [active] 1016998011319 putative MgATP binding site [chemical binding]; other site 1016998011320 catalytic site [active] 1016998011321 metal binding site [ion binding]; metal-binding site 1016998011322 putative carbohydrate binding site [chemical binding]; other site 1016998011323 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1016998011324 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1016998011325 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1016998011326 active site 1016998011327 P-loop; other site 1016998011328 phosphorylation site [posttranslational modification] 1016998011329 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1016998011330 active site 1016998011331 phosphorylation site [posttranslational modification] 1016998011332 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1016998011333 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1016998011334 DNA-binding site [nucleotide binding]; DNA binding site 1016998011335 UTRA domain; Region: UTRA; pfam07702 1016998011336 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 1016998011337 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 1016998011338 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998011339 putative substrate translocation pore; other site 1016998011340 regulatory protein UhpC; Provisional; Region: PRK11663 1016998011341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998011342 putative substrate translocation pore; other site 1016998011343 sensory histidine kinase UhpB; Provisional; Region: PRK11644 1016998011344 MASE1; Region: MASE1; pfam05231 1016998011345 Histidine kinase; Region: HisKA_3; pfam07730 1016998011346 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1016998011347 ATP binding site [chemical binding]; other site 1016998011348 Mg2+ binding site [ion binding]; other site 1016998011349 G-X-G motif; other site 1016998011350 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 1016998011351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1016998011352 active site 1016998011353 phosphorylation site [posttranslational modification] 1016998011354 intermolecular recognition site; other site 1016998011355 dimerization interface [polypeptide binding]; other site 1016998011356 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1016998011357 DNA binding residues [nucleotide binding] 1016998011358 dimerization interface [polypeptide binding]; other site 1016998011359 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 1016998011360 active site 1016998011361 catalytic residues [active] 1016998011362 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1016998011363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998011364 putative substrate translocation pore; other site 1016998011365 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1016998011366 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1016998011367 substrate binding site [chemical binding]; other site 1016998011368 dimer interface [polypeptide binding]; other site 1016998011369 ATP binding site [chemical binding]; other site 1016998011370 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 1016998011371 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1016998011372 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1016998011373 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 1016998011374 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1016998011375 putative valine binding site [chemical binding]; other site 1016998011376 dimer interface [polypeptide binding]; other site 1016998011377 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 1016998011378 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1016998011379 PYR/PP interface [polypeptide binding]; other site 1016998011380 dimer interface [polypeptide binding]; other site 1016998011381 TPP binding site [chemical binding]; other site 1016998011382 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1016998011383 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1016998011384 TPP-binding site [chemical binding]; other site 1016998011385 dimer interface [polypeptide binding]; other site 1016998011386 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1016998011387 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1016998011388 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 1016998011389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998011390 putative substrate translocation pore; other site 1016998011391 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1016998011392 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 1016998011393 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998011394 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1016998011395 dimerization interface [polypeptide binding]; other site 1016998011396 substrate binding pocket [chemical binding]; other site 1016998011397 permease DsdX; Provisional; Region: PRK09921 1016998011398 gluconate transporter; Region: gntP; TIGR00791 1016998011399 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1016998011400 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1016998011401 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1016998011402 catalytic residue [active] 1016998011403 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 1016998011404 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 1016998011405 Domain of unknown function (DUF202); Region: DUF202; pfam02656 1016998011406 Predicted membrane protein [Function unknown]; Region: COG2149 1016998011407 putative transporter; Validated; Region: PRK03818 1016998011408 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1016998011409 TrkA-C domain; Region: TrkA_C; pfam02080 1016998011410 TrkA-C domain; Region: TrkA_C; pfam02080 1016998011411 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1016998011412 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1016998011413 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1016998011414 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1016998011415 putative dimer interface [polypeptide binding]; other site 1016998011416 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1016998011417 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1016998011418 putative dimer interface [polypeptide binding]; other site 1016998011419 hypothetical protein; Provisional; Region: PRK11616 1016998011420 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 1016998011421 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 1016998011422 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 1016998011423 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 1016998011424 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1016998011425 catalytic residues [active] 1016998011426 central insert; other site 1016998011427 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 1016998011428 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150 1016998011429 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 1016998011430 heme exporter protein CcmC; Region: ccmC; TIGR01191 1016998011431 heme exporter protein CcmB; Region: ccmB; TIGR01190 1016998011432 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1016998011433 Walker A/P-loop; other site 1016998011434 ATP binding site [chemical binding]; other site 1016998011435 Q-loop/lid; other site 1016998011436 ABC transporter signature motif; other site 1016998011437 Walker B; other site 1016998011438 D-loop; other site 1016998011439 H-loop/switch region; other site 1016998011440 Haem-binding domain; Region: Haem_bd; pfam14376 1016998011441 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 1016998011442 chaperone protein TorD; Validated; Region: torD; PRK04976 1016998011443 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 1016998011444 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1016998011445 molybdopterin cofactor binding site [chemical binding]; other site 1016998011446 substrate binding site [chemical binding]; other site 1016998011447 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1016998011448 molybdopterin cofactor binding site; other site 1016998011449 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 1016998011450 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 1016998011451 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 1016998011452 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1016998011453 active site 1016998011454 phosphorylation site [posttranslational modification] 1016998011455 intermolecular recognition site; other site 1016998011456 dimerization interface [polypeptide binding]; other site 1016998011457 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1016998011458 DNA binding site [nucleotide binding] 1016998011459 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 1016998011460 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1016998011461 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 1016998011462 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1016998011463 dimer interface [polypeptide binding]; other site 1016998011464 phosphorylation site [posttranslational modification] 1016998011465 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1016998011466 ATP binding site [chemical binding]; other site 1016998011467 Mg2+ binding site [ion binding]; other site 1016998011468 G-X-G motif; other site 1016998011469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1016998011470 active site 1016998011471 phosphorylation site [posttranslational modification] 1016998011472 intermolecular recognition site; other site 1016998011473 dimerization interface [polypeptide binding]; other site 1016998011474 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1016998011475 putative binding surface; other site 1016998011476 active site 1016998011477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998011478 D-galactonate transporter; Region: 2A0114; TIGR00893 1016998011479 putative substrate translocation pore; other site 1016998011480 galactonate dehydratase; Provisional; Region: PRK14017 1016998011481 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 1016998011482 putative active site pocket [active] 1016998011483 putative metal binding site [ion binding]; other site 1016998011484 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 1016998011485 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1016998011486 active site 1016998011487 intersubunit interface [polypeptide binding]; other site 1016998011488 catalytic residue [active] 1016998011489 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 1016998011490 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 1016998011491 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1016998011492 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1016998011493 DNA-binding site [nucleotide binding]; DNA binding site 1016998011494 FCD domain; Region: FCD; pfam07729 1016998011495 sugar phosphate phosphatase; Provisional; Region: PRK10513 1016998011496 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1016998011497 active site 1016998011498 motif I; other site 1016998011499 motif II; other site 1016998011500 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1016998011501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998011502 D-galactonate transporter; Region: 2A0114; TIGR00893 1016998011503 putative substrate translocation pore; other site 1016998011504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998011505 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1016998011506 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1016998011507 active site pocket [active] 1016998011508 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1016998011509 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998011510 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1016998011511 putative dimerization interface [polypeptide binding]; other site 1016998011512 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1016998011513 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1016998011514 Mg2+ binding site [ion binding]; other site 1016998011515 G-X-G motif; other site 1016998011516 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1016998011517 anchoring element; other site 1016998011518 dimer interface [polypeptide binding]; other site 1016998011519 ATP binding site [chemical binding]; other site 1016998011520 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1016998011521 active site 1016998011522 putative metal-binding site [ion binding]; other site 1016998011523 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1016998011524 recF protein; Region: recf; TIGR00611 1016998011525 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1016998011526 Walker A/P-loop; other site 1016998011527 ATP binding site [chemical binding]; other site 1016998011528 Q-loop/lid; other site 1016998011529 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1016998011530 ABC transporter signature motif; other site 1016998011531 Walker B; other site 1016998011532 D-loop; other site 1016998011533 H-loop/switch region; other site 1016998011534 DNA polymerase III subunit beta; Validated; Region: PRK05643 1016998011535 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1016998011536 putative DNA binding surface [nucleotide binding]; other site 1016998011537 dimer interface [polypeptide binding]; other site 1016998011538 beta-clamp/clamp loader binding surface; other site 1016998011539 beta-clamp/translesion DNA polymerase binding surface; other site 1016998011540 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1016998011541 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1016998011542 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1016998011543 Walker A motif; other site 1016998011544 ATP binding site [chemical binding]; other site 1016998011545 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1016998011546 Walker B motif; other site 1016998011547 arginine finger; other site 1016998011548 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1016998011549 DnaA box-binding interface [nucleotide binding]; other site 1016998011550 ent-kaur-16-ene synthase; Region: PLN02279 1016998011551 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1016998011552 ribonuclease P; Reviewed; Region: rnpA; PRK01732 1016998011553 Haemolytic domain; Region: Haemolytic; cl00506 1016998011554 membrane protein insertase; Provisional; Region: PRK01318 1016998011555 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1016998011556 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1016998011557 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1016998011558 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1016998011559 G1 box; other site 1016998011560 GTP/Mg2+ binding site [chemical binding]; other site 1016998011561 Switch I region; other site 1016998011562 G2 box; other site 1016998011563 Switch II region; other site 1016998011564 G3 box; other site 1016998011565 G4 box; other site 1016998011566 G5 box; other site 1016998011567 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1016998011568 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 1016998011569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998011570 putative substrate translocation pore; other site 1016998011571 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 1016998011572 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998011573 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1016998011574 substrate binding pocket [chemical binding]; other site 1016998011575 dimerization interface [polypeptide binding]; other site 1016998011576 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1016998011577 Predicted flavoprotein [General function prediction only]; Region: COG0431 1016998011578 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1016998011579 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1016998011580 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 1016998011581 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1016998011582 active site 1016998011583 motif I; other site 1016998011584 motif II; other site 1016998011585 transcriptional regulator PhoU; Provisional; Region: PRK11115 1016998011586 PhoU domain; Region: PhoU; pfam01895 1016998011587 PhoU domain; Region: PhoU; pfam01895 1016998011588 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 1016998011589 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1016998011590 Walker A/P-loop; other site 1016998011591 ATP binding site [chemical binding]; other site 1016998011592 Q-loop/lid; other site 1016998011593 ABC transporter signature motif; other site 1016998011594 Walker B; other site 1016998011595 D-loop; other site 1016998011596 H-loop/switch region; other site 1016998011597 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 1016998011598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998011599 dimer interface [polypeptide binding]; other site 1016998011600 conserved gate region; other site 1016998011601 putative PBP binding loops; other site 1016998011602 ABC-ATPase subunit interface; other site 1016998011603 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 1016998011604 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998011605 dimer interface [polypeptide binding]; other site 1016998011606 conserved gate region; other site 1016998011607 putative PBP binding loops; other site 1016998011608 ABC-ATPase subunit interface; other site 1016998011609 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1016998011610 substrate binding pocket [chemical binding]; other site 1016998011611 membrane-bound complex binding site; other site 1016998011612 hinge residues; other site 1016998011613 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1016998011614 active site 1016998011615 P-loop; other site 1016998011616 phosphorylation site [posttranslational modification] 1016998011617 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 1016998011618 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1016998011619 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 1016998011620 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1016998011621 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1016998011622 shikimate binding site; other site 1016998011623 NAD(P) binding site [chemical binding]; other site 1016998011624 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1016998011625 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1016998011626 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1016998011627 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1016998011628 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1016998011629 glutaminase active site [active] 1016998011630 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1016998011631 dimer interface [polypeptide binding]; other site 1016998011632 active site 1016998011633 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1016998011634 dimer interface [polypeptide binding]; other site 1016998011635 active site 1016998011636 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 1016998011637 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1016998011638 Substrate binding site; other site 1016998011639 Mg++ binding site; other site 1016998011640 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1016998011641 active site 1016998011642 substrate binding site [chemical binding]; other site 1016998011643 CoA binding site [chemical binding]; other site 1016998011644 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1016998011645 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 1016998011646 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1016998011647 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1016998011648 gamma subunit interface [polypeptide binding]; other site 1016998011649 LBP interface [polypeptide binding]; other site 1016998011650 epsilon subunit interface [polypeptide binding]; other site 1016998011651 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1016998011652 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1016998011653 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1016998011654 alpha subunit interaction interface [polypeptide binding]; other site 1016998011655 Walker A motif; other site 1016998011656 ATP binding site [chemical binding]; other site 1016998011657 Walker B motif; other site 1016998011658 inhibitor binding site; inhibition site 1016998011659 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1016998011660 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1016998011661 core domain interface [polypeptide binding]; other site 1016998011662 delta subunit interface [polypeptide binding]; other site 1016998011663 epsilon subunit interface [polypeptide binding]; other site 1016998011664 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1016998011665 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1016998011666 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1016998011667 beta subunit interaction interface [polypeptide binding]; other site 1016998011668 Walker A motif; other site 1016998011669 ATP binding site [chemical binding]; other site 1016998011670 Walker B motif; other site 1016998011671 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1016998011672 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1016998011673 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1016998011674 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1016998011675 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1016998011676 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1016998011677 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1016998011678 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1016998011679 ATP synthase I chain; Region: ATP_synt_I; cl09170 1016998011680 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1016998011681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1016998011682 S-adenosylmethionine binding site [chemical binding]; other site 1016998011683 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1016998011684 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1016998011685 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1016998011686 FMN-binding protein MioC; Provisional; Region: PRK09004 1016998011687 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 1016998011688 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1016998011689 putative DNA binding site [nucleotide binding]; other site 1016998011690 putative Zn2+ binding site [ion binding]; other site 1016998011691 AsnC family; Region: AsnC_trans_reg; pfam01037 1016998011692 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 1016998011693 dimer interface [polypeptide binding]; other site 1016998011694 active site 1016998011695 hypothetical protein; Provisional; Region: yieM; PRK10997 1016998011696 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1016998011697 metal ion-dependent adhesion site (MIDAS); other site 1016998011698 regulatory ATPase RavA; Provisional; Region: PRK13531 1016998011699 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1016998011700 Walker A motif; other site 1016998011701 ATP binding site [chemical binding]; other site 1016998011702 Walker B motif; other site 1016998011703 arginine finger; other site 1016998011704 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 1016998011705 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 1016998011706 potassium uptake protein; Region: kup; TIGR00794 1016998011707 D-ribose pyranase; Provisional; Region: PRK11797 1016998011708 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 1016998011709 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1016998011710 Walker A/P-loop; other site 1016998011711 ATP binding site [chemical binding]; other site 1016998011712 Q-loop/lid; other site 1016998011713 ABC transporter signature motif; other site 1016998011714 Walker B; other site 1016998011715 D-loop; other site 1016998011716 H-loop/switch region; other site 1016998011717 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1016998011718 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1016998011719 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1016998011720 TM-ABC transporter signature motif; other site 1016998011721 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1016998011722 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1016998011723 ligand binding site [chemical binding]; other site 1016998011724 dimerization interface [polypeptide binding]; other site 1016998011725 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1016998011726 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1016998011727 substrate binding site [chemical binding]; other site 1016998011728 dimer interface [polypeptide binding]; other site 1016998011729 ATP binding site [chemical binding]; other site 1016998011730 transcriptional repressor RbsR; Provisional; Region: PRK10423 1016998011731 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1016998011732 DNA binding site [nucleotide binding] 1016998011733 domain linker motif; other site 1016998011734 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1016998011735 dimerization interface [polypeptide binding]; other site 1016998011736 ligand binding site [chemical binding]; other site 1016998011737 putative transporter; Provisional; Region: PRK10504 1016998011738 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998011739 putative substrate translocation pore; other site 1016998011740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998011741 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1016998011742 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1016998011743 DNA-binding site [nucleotide binding]; DNA binding site 1016998011744 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1016998011745 transcriptional regulator HdfR; Provisional; Region: PRK03601 1016998011746 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998011747 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1016998011748 dimerization interface [polypeptide binding]; other site 1016998011749 hypothetical protein; Provisional; Region: PRK11027 1016998011750 putative ATP-dependent protease; Provisional; Region: PRK09862 1016998011751 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1016998011752 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1016998011753 Walker A motif; other site 1016998011754 ATP binding site [chemical binding]; other site 1016998011755 Walker B motif; other site 1016998011756 arginine finger; other site 1016998011757 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1016998011758 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1016998011759 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 1016998011760 PYR/PP interface [polypeptide binding]; other site 1016998011761 dimer interface [polypeptide binding]; other site 1016998011762 TPP binding site [chemical binding]; other site 1016998011763 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1016998011764 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1016998011765 TPP-binding site [chemical binding]; other site 1016998011766 dimer interface [polypeptide binding]; other site 1016998011767 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 1016998011768 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1016998011769 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1016998011770 homodimer interface [polypeptide binding]; other site 1016998011771 substrate-cofactor binding pocket; other site 1016998011772 catalytic residue [active] 1016998011773 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1016998011774 threonine dehydratase; Reviewed; Region: PRK09224 1016998011775 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1016998011776 tetramer interface [polypeptide binding]; other site 1016998011777 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998011778 catalytic residue [active] 1016998011779 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1016998011780 putative Ile/Val binding site [chemical binding]; other site 1016998011781 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1016998011782 putative Ile/Val binding site [chemical binding]; other site 1016998011783 Phage-related protein [Function unknown]; Region: COG4679 1016998011784 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 1016998011785 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998011786 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 1016998011787 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 1016998011788 putative dimerization interface [polypeptide binding]; other site 1016998011789 ketol-acid reductoisomerase; Validated; Region: PRK05225 1016998011790 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1016998011791 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1016998011792 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1016998011793 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 1016998011794 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1016998011795 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 1016998011796 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 1016998011797 Part of AAA domain; Region: AAA_19; pfam13245 1016998011798 Family description; Region: UvrD_C_2; pfam13538 1016998011799 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 1016998011800 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1016998011801 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1016998011802 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1016998011803 ATP binding site [chemical binding]; other site 1016998011804 Mg++ binding site [ion binding]; other site 1016998011805 motif III; other site 1016998011806 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1016998011807 nucleotide binding region [chemical binding]; other site 1016998011808 ATP-binding site [chemical binding]; other site 1016998011809 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1016998011810 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1016998011811 catalytic residues [active] 1016998011812 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1016998011813 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1016998011814 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1016998011815 RNA binding site [nucleotide binding]; other site 1016998011816 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1016998011817 multimer interface [polypeptide binding]; other site 1016998011818 Walker A motif; other site 1016998011819 ATP binding site [chemical binding]; other site 1016998011820 Walker B motif; other site 1016998011821 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 1016998011822 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1016998011823 Mg++ binding site [ion binding]; other site 1016998011824 putative catalytic motif [active] 1016998011825 substrate binding site [chemical binding]; other site 1016998011826 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 1016998011827 Chain length determinant protein; Region: Wzz; pfam02706 1016998011828 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1016998011829 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1016998011830 homodimer interface [polypeptide binding]; other site 1016998011831 active site 1016998011832 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 1016998011833 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1016998011834 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1016998011835 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 1016998011836 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1016998011837 NAD binding site [chemical binding]; other site 1016998011838 substrate binding site [chemical binding]; other site 1016998011839 homodimer interface [polypeptide binding]; other site 1016998011840 active site 1016998011841 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1016998011842 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1016998011843 substrate binding site; other site 1016998011844 tetramer interface; other site 1016998011845 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 1016998011846 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1016998011847 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1016998011848 inhibitor-cofactor binding pocket; inhibition site 1016998011849 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998011850 catalytic residue [active] 1016998011851 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1016998011852 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 1016998011853 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 1016998011854 putative common antigen polymerase; Provisional; Region: PRK02975 1016998011855 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1016998011856 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1016998011857 putative transport protein YifK; Provisional; Region: PRK10746 1016998011858 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 1016998011859 HemY protein N-terminus; Region: HemY_N; pfam07219 1016998011860 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1016998011861 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 1016998011862 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1016998011863 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1016998011864 active site 1016998011865 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1016998011866 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1016998011867 active site 1016998011868 domain interfaces; other site 1016998011869 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 1016998011870 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 1016998011871 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 1016998011872 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 1016998011873 putative iron binding site [ion binding]; other site 1016998011874 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 1016998011875 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 1016998011876 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1016998011877 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1016998011878 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1016998011879 hypothetical protein; Provisional; Region: PRK10963 1016998011880 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 1016998011881 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1016998011882 active site 1016998011883 Int/Topo IB signature motif; other site 1016998011884 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 1016998011885 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1016998011886 motif II; other site 1016998011887 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1016998011888 Part of AAA domain; Region: AAA_19; pfam13245 1016998011889 Family description; Region: UvrD_C_2; pfam13538 1016998011890 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1016998011891 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 1016998011892 Cl binding site [ion binding]; other site 1016998011893 oligomer interface [polypeptide binding]; other site 1016998011894 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 1016998011895 EamA-like transporter family; Region: EamA; cl17759 1016998011896 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1016998011897 CoenzymeA binding site [chemical binding]; other site 1016998011898 subunit interaction site [polypeptide binding]; other site 1016998011899 PHB binding site; other site 1016998011900 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 1016998011901 dimerization interface [polypeptide binding]; other site 1016998011902 substrate binding site [chemical binding]; other site 1016998011903 active site 1016998011904 calcium binding site [ion binding]; other site 1016998011905 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 1016998011906 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1016998011907 ATP binding site [chemical binding]; other site 1016998011908 putative Mg++ binding site [ion binding]; other site 1016998011909 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1016998011910 nucleotide binding region [chemical binding]; other site 1016998011911 ATP-binding site [chemical binding]; other site 1016998011912 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1016998011913 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1016998011914 threonine efflux system; Provisional; Region: PRK10229 1016998011915 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 1016998011916 lysophospholipase L2; Provisional; Region: PRK10749 1016998011917 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1016998011918 putative hydrolase; Provisional; Region: PRK10976 1016998011919 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1016998011920 active site 1016998011921 motif I; other site 1016998011922 motif II; other site 1016998011923 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1016998011924 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 1016998011925 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998011926 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 1016998011927 putative dimerization interface [polypeptide binding]; other site 1016998011928 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1016998011929 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1016998011930 THF binding site; other site 1016998011931 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1016998011932 substrate binding site [chemical binding]; other site 1016998011933 THF binding site; other site 1016998011934 zinc-binding site [ion binding]; other site 1016998011935 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1016998011936 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1016998011937 FeS/SAM binding site; other site 1016998011938 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1016998011939 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1016998011940 uridine phosphorylase; Provisional; Region: PRK11178 1016998011941 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 1016998011942 DNA recombination protein RmuC; Provisional; Region: PRK10361 1016998011943 RmuC family; Region: RmuC; pfam02646 1016998011944 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1016998011945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1016998011946 S-adenosylmethionine binding site [chemical binding]; other site 1016998011947 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 1016998011948 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1016998011949 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1016998011950 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 1016998011951 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1016998011952 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 1016998011953 sec-independent translocase; Provisional; Region: PRK01770 1016998011954 sec-independent translocase; Provisional; Region: tatB; PRK00404 1016998011955 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 1016998011956 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1016998011957 active site 1016998011958 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 1016998011959 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 1016998011960 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 1016998011961 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 1016998011962 FMN reductase; Validated; Region: fre; PRK08051 1016998011963 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1016998011964 FAD binding pocket [chemical binding]; other site 1016998011965 FAD binding motif [chemical binding]; other site 1016998011966 phosphate binding motif [ion binding]; other site 1016998011967 beta-alpha-beta structure motif; other site 1016998011968 NAD binding pocket [chemical binding]; other site 1016998011969 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 1016998011970 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 1016998011971 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1016998011972 dimer interface [polypeptide binding]; other site 1016998011973 active site 1016998011974 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1016998011975 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1016998011976 substrate binding site [chemical binding]; other site 1016998011977 oxyanion hole (OAH) forming residues; other site 1016998011978 trimer interface [polypeptide binding]; other site 1016998011979 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1016998011980 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1016998011981 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1016998011982 proline dipeptidase; Provisional; Region: PRK13607 1016998011983 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1016998011984 active site 1016998011985 hypothetical protein; Provisional; Region: PRK11568 1016998011986 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1016998011987 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1016998011988 potassium transporter; Provisional; Region: PRK10750 1016998011989 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1016998011990 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 1016998011991 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1016998011992 Walker A motif; other site 1016998011993 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1016998011994 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1016998011995 GTP binding site; other site 1016998011996 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 1016998011997 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1016998011998 serine/threonine protein kinase; Provisional; Region: PRK11768 1016998011999 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1016998012000 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1016998012001 catalytic residues [active] 1016998012002 hinge region; other site 1016998012003 alpha helical domain; other site 1016998012004 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1016998012005 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1016998012006 putative acyl-acceptor binding pocket; other site 1016998012007 DNA polymerase I; Provisional; Region: PRK05755 1016998012008 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1016998012009 active site 1016998012010 metal binding site 1 [ion binding]; metal-binding site 1016998012011 putative 5' ssDNA interaction site; other site 1016998012012 metal binding site 3; metal-binding site 1016998012013 metal binding site 2 [ion binding]; metal-binding site 1016998012014 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1016998012015 putative DNA binding site [nucleotide binding]; other site 1016998012016 putative metal binding site [ion binding]; other site 1016998012017 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1016998012018 active site 1016998012019 catalytic site [active] 1016998012020 substrate binding site [chemical binding]; other site 1016998012021 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1016998012022 active site 1016998012023 DNA binding site [nucleotide binding] 1016998012024 catalytic site [active] 1016998012025 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1016998012026 G1 box; other site 1016998012027 GTP/Mg2+ binding site [chemical binding]; other site 1016998012028 Switch I region; other site 1016998012029 G2 box; other site 1016998012030 G3 box; other site 1016998012031 Switch II region; other site 1016998012032 G4 box; other site 1016998012033 G5 box; other site 1016998012034 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 1016998012035 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1016998012036 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1016998012037 FeS/SAM binding site; other site 1016998012038 HemN C-terminal domain; Region: HemN_C; pfam06969 1016998012039 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 1016998012040 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1016998012041 active site 1016998012042 phosphorylation site [posttranslational modification] 1016998012043 intermolecular recognition site; other site 1016998012044 dimerization interface [polypeptide binding]; other site 1016998012045 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1016998012046 Walker A motif; other site 1016998012047 ATP binding site [chemical binding]; other site 1016998012048 Walker B motif; other site 1016998012049 arginine finger; other site 1016998012050 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1016998012051 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 1016998012052 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1016998012053 putative active site [active] 1016998012054 heme pocket [chemical binding]; other site 1016998012055 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1016998012056 dimer interface [polypeptide binding]; other site 1016998012057 phosphorylation site [posttranslational modification] 1016998012058 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1016998012059 ATP binding site [chemical binding]; other site 1016998012060 Mg2+ binding site [ion binding]; other site 1016998012061 G-X-G motif; other site 1016998012062 glutamine synthetase; Provisional; Region: glnA; PRK09469 1016998012063 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1016998012064 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1016998012065 GTP-binding protein; Provisional; Region: PRK10218 1016998012066 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1016998012067 G1 box; other site 1016998012068 putative GEF interaction site [polypeptide binding]; other site 1016998012069 GTP/Mg2+ binding site [chemical binding]; other site 1016998012070 Switch I region; other site 1016998012071 G2 box; other site 1016998012072 G3 box; other site 1016998012073 Switch II region; other site 1016998012074 G4 box; other site 1016998012075 G5 box; other site 1016998012076 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1016998012077 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1016998012078 outer membrane porin L; Provisional; Region: ompL; PRK09980 1016998012079 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1016998012080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998012081 putative substrate translocation pore; other site 1016998012082 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1016998012083 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998012084 putative substrate translocation pore; other site 1016998012085 alpha-glucosidase; Provisional; Region: PRK10426 1016998012086 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1016998012087 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 1016998012088 putative active site [active] 1016998012089 putative catalytic site [active] 1016998012090 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1016998012091 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 1016998012092 active site 1016998012093 catalytic residues [active] 1016998012094 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 1016998012095 dimerization interface [polypeptide binding]; other site 1016998012096 putative active cleft [active] 1016998012097 Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684 1016998012098 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 1016998012099 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1016998012100 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1016998012101 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 1016998012102 substrate binding site [chemical binding]; other site 1016998012103 ATP binding site [chemical binding]; other site 1016998012104 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1016998012105 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1016998012106 putative DNA binding site [nucleotide binding]; other site 1016998012107 putative Zn2+ binding site [ion binding]; other site 1016998012108 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1016998012109 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1016998012110 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1016998012111 motif II; other site 1016998012112 hypothetical protein; Reviewed; Region: PRK01637 1016998012113 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1016998012114 putative active site [active] 1016998012115 dimerization interface [polypeptide binding]; other site 1016998012116 putative tRNAtyr binding site [nucleotide binding]; other site 1016998012117 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1016998012118 Coenzyme A binding pocket [chemical binding]; other site 1016998012119 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 1016998012120 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1016998012121 non-specific DNA binding site [nucleotide binding]; other site 1016998012122 salt bridge; other site 1016998012123 sequence-specific DNA binding site [nucleotide binding]; other site 1016998012124 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680 1016998012125 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1016998012126 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1016998012127 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1016998012128 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1016998012129 oligomeric interface; other site 1016998012130 putative active site [active] 1016998012131 homodimer interface [polypeptide binding]; other site 1016998012132 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 1016998012133 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1016998012134 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 1016998012135 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1016998012136 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1016998012137 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1016998012138 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1016998012139 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 1016998012140 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 1016998012141 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1016998012142 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1016998012143 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1016998012144 non-specific DNA binding site [nucleotide binding]; other site 1016998012145 salt bridge; other site 1016998012146 sequence-specific DNA binding site [nucleotide binding]; other site 1016998012147 Cupin domain; Region: Cupin_2; cl17218 1016998012148 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 1016998012149 lactaldehyde reductase; Region: lactal_redase; TIGR02638 1016998012150 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1016998012151 dimer interface [polypeptide binding]; other site 1016998012152 active site 1016998012153 metal binding site [ion binding]; metal-binding site 1016998012154 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1016998012155 intersubunit interface [polypeptide binding]; other site 1016998012156 active site 1016998012157 Zn2+ binding site [ion binding]; other site 1016998012158 L-rhamnose isomerase; Provisional; Region: PRK01076 1016998012159 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 1016998012160 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1016998012161 N- and C-terminal domain interface [polypeptide binding]; other site 1016998012162 active site 1016998012163 putative catalytic site [active] 1016998012164 metal binding site [ion binding]; metal-binding site 1016998012165 ATP binding site [chemical binding]; other site 1016998012166 rhamnulokinase; Provisional; Region: rhaB; PRK10640 1016998012167 carbohydrate binding site [chemical binding]; other site 1016998012168 transcriptional activator RhaS; Provisional; Region: PRK13503 1016998012169 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1016998012170 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1016998012171 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1016998012172 transcriptional activator RhaR; Provisional; Region: PRK13502 1016998012173 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1016998012174 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1016998012175 L-rhamnose-proton symport protein (RhaT); Region: RhaT; pfam06379 1016998012176 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 1016998012177 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178 1016998012178 DctM-like transporters; Region: DctM; pfam06808 1016998012179 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1016998012180 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1016998012181 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1016998012182 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1016998012183 superoxide dismutase; Provisional; Region: PRK10925 1016998012184 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1016998012185 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1016998012186 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 1016998012187 MOSC domain; Region: MOSC; pfam03473 1016998012188 3-alpha domain; Region: 3-alpha; pfam03475 1016998012189 SnoaL-like domain; Region: SnoaL_2; pfam12680 1016998012190 two-component sensor protein; Provisional; Region: cpxA; PRK09470 1016998012191 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1016998012192 dimerization interface [polypeptide binding]; other site 1016998012193 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1016998012194 dimer interface [polypeptide binding]; other site 1016998012195 phosphorylation site [posttranslational modification] 1016998012196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1016998012197 ATP binding site [chemical binding]; other site 1016998012198 Mg2+ binding site [ion binding]; other site 1016998012199 G-X-G motif; other site 1016998012200 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 1016998012201 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1016998012202 active site 1016998012203 intermolecular recognition site; other site 1016998012204 dimerization interface [polypeptide binding]; other site 1016998012205 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1016998012206 DNA binding site [nucleotide binding] 1016998012207 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1016998012208 dimer interface [polypeptide binding]; other site 1016998012209 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 1016998012210 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1016998012211 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1016998012212 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1016998012213 active site 1016998012214 ADP/pyrophosphate binding site [chemical binding]; other site 1016998012215 dimerization interface [polypeptide binding]; other site 1016998012216 allosteric effector site; other site 1016998012217 fructose-1,6-bisphosphate binding site; other site 1016998012218 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1016998012219 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1016998012220 substrate binding pocket [chemical binding]; other site 1016998012221 membrane-bound complex binding site; other site 1016998012222 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 1016998012223 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1016998012224 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1016998012225 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1016998012226 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1016998012227 putative substrate binding site [chemical binding]; other site 1016998012228 putative ATP binding site [chemical binding]; other site 1016998012229 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 1016998012230 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1016998012231 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1016998012232 DNA-binding site [nucleotide binding]; DNA binding site 1016998012233 Alanine racemase, C-terminal domain; Region: Ala_racemase_C; cl08293 1016998012234 UTRA domain; Region: UTRA; pfam07702 1016998012235 CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934 1016998012236 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1016998012237 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 1016998012238 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 1016998012239 putative N- and C-terminal domain interface [polypeptide binding]; other site 1016998012240 putative active site [active] 1016998012241 putative MgATP binding site [chemical binding]; other site 1016998012242 catalytic site [active] 1016998012243 metal binding site [ion binding]; metal-binding site 1016998012244 putative carbohydrate binding site [chemical binding]; other site 1016998012245 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1016998012246 transcriptional regulator LsrR; Provisional; Region: PRK15418 1016998012247 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1016998012248 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1016998012249 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 1016998012250 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1016998012251 Walker A/P-loop; other site 1016998012252 ATP binding site [chemical binding]; other site 1016998012253 Q-loop/lid; other site 1016998012254 ABC transporter signature motif; other site 1016998012255 Walker B; other site 1016998012256 D-loop; other site 1016998012257 H-loop/switch region; other site 1016998012258 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1016998012259 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1016998012260 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1016998012261 TM-ABC transporter signature motif; other site 1016998012262 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1016998012263 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1016998012264 TM-ABC transporter signature motif; other site 1016998012265 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 1016998012266 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1016998012267 ligand binding site [chemical binding]; other site 1016998012268 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1016998012269 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1016998012270 putative active site; other site 1016998012271 catalytic residue [active] 1016998012272 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 1016998012273 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1016998012274 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1016998012275 substrate binding site [chemical binding]; other site 1016998012276 hexamer interface [polypeptide binding]; other site 1016998012277 metal binding site [ion binding]; metal-binding site 1016998012278 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1016998012279 triosephosphate isomerase; Provisional; Region: PRK14567 1016998012280 substrate binding site [chemical binding]; other site 1016998012281 dimer interface [polypeptide binding]; other site 1016998012282 catalytic triad [active] 1016998012283 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 1016998012284 Predicted membrane protein [Function unknown]; Region: COG3152 1016998012285 ferredoxin-NADP reductase; Provisional; Region: PRK10926 1016998012286 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1016998012287 FAD binding pocket [chemical binding]; other site 1016998012288 FAD binding motif [chemical binding]; other site 1016998012289 phosphate binding motif [ion binding]; other site 1016998012290 beta-alpha-beta structure motif; other site 1016998012291 NAD binding pocket [chemical binding]; other site 1016998012292 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1016998012293 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1016998012294 putative active site [active] 1016998012295 glycerol kinase; Provisional; Region: glpK; PRK00047 1016998012296 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1016998012297 N- and C-terminal domain interface [polypeptide binding]; other site 1016998012298 active site 1016998012299 MgATP binding site [chemical binding]; other site 1016998012300 catalytic site [active] 1016998012301 metal binding site [ion binding]; metal-binding site 1016998012302 glycerol binding site [chemical binding]; other site 1016998012303 homotetramer interface [polypeptide binding]; other site 1016998012304 homodimer interface [polypeptide binding]; other site 1016998012305 FBP binding site [chemical binding]; other site 1016998012306 protein IIAGlc interface [polypeptide binding]; other site 1016998012307 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1016998012308 amphipathic channel; other site 1016998012309 Asn-Pro-Ala signature motifs; other site 1016998012310 septal ring assembly protein ZapB; Provisional; Region: PRK15422 1016998012311 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 1016998012312 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 1016998012313 UbiA prenyltransferase family; Region: UbiA; pfam01040 1016998012314 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1016998012315 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1016998012316 Walker A motif; other site 1016998012317 ATP binding site [chemical binding]; other site 1016998012318 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1016998012319 Walker B motif; other site 1016998012320 arginine finger; other site 1016998012321 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1016998012322 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1016998012323 active site 1016998012324 HslU subunit interaction site [polypeptide binding]; other site 1016998012325 essential cell division protein FtsN; Provisional; Region: PRK10927 1016998012326 cell division protein FtsN; Provisional; Region: PRK12757 1016998012327 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1016998012328 DNA binding site [nucleotide binding] 1016998012329 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 1016998012330 domain linker motif; other site 1016998012331 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 1016998012332 dimerization interface [polypeptide binding]; other site 1016998012333 ligand binding site [chemical binding]; other site 1016998012334 primosome assembly protein PriA; Validated; Region: PRK05580 1016998012335 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1016998012336 ATP binding site [chemical binding]; other site 1016998012337 putative Mg++ binding site [ion binding]; other site 1016998012338 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1016998012339 ATP-binding site [chemical binding]; other site 1016998012340 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1016998012341 conserved hypothetical protein; Region: chp_urease_rgn; TIGR02117 1016998012342 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 1016998012343 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 1016998012344 dimerization interface [polypeptide binding]; other site 1016998012345 DNA binding site [nucleotide binding] 1016998012346 corepressor binding sites; other site 1016998012347 cystathionine gamma-synthase; Provisional; Region: PRK08045 1016998012348 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1016998012349 homodimer interface [polypeptide binding]; other site 1016998012350 substrate-cofactor binding pocket; other site 1016998012351 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998012352 catalytic residue [active] 1016998012353 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 1016998012354 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1016998012355 putative catalytic residues [active] 1016998012356 putative nucleotide binding site [chemical binding]; other site 1016998012357 putative aspartate binding site [chemical binding]; other site 1016998012358 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 1016998012359 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1016998012360 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1016998012361 mechanosensitive channel MscS; Provisional; Region: PRK10334 1016998012362 Conserved TM helix; Region: TM_helix; pfam05552 1016998012363 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1016998012364 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1016998012365 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1016998012366 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1016998012367 active site 1016998012368 metal binding site [ion binding]; metal-binding site 1016998012369 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1016998012370 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1016998012371 FAD binding site [chemical binding]; other site 1016998012372 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1016998012373 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1016998012374 heme binding site [chemical binding]; other site 1016998012375 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1016998012376 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 1016998012377 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1016998012378 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1016998012379 dimer interface [polypeptide binding]; other site 1016998012380 active site 1016998012381 metal binding site [ion binding]; metal-binding site 1016998012382 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1016998012383 active site 1016998012384 intersubunit interactions; other site 1016998012385 catalytic residue [active] 1016998012386 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1016998012387 dimerization domain swap beta strand [polypeptide binding]; other site 1016998012388 regulatory protein interface [polypeptide binding]; other site 1016998012389 active site 1016998012390 regulatory phosphorylation site [posttranslational modification]; other site 1016998012391 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1016998012392 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1016998012393 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1016998012394 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1016998012395 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1016998012396 active site 1016998012397 phosphorylation site [posttranslational modification] 1016998012398 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 1016998012399 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1016998012400 active site 1016998012401 P-loop; other site 1016998012402 phosphorylation site [posttranslational modification] 1016998012403 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 1016998012404 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1016998012405 dimer interface [polypeptide binding]; other site 1016998012406 active site 1016998012407 glycine loop; other site 1016998012408 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1016998012409 FeS/SAM binding site; other site 1016998012410 pyruvate formate lyase II activase; Provisional; Region: PRK10076 1016998012411 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1016998012412 active site 1016998012413 P-loop; other site 1016998012414 phosphorylation site [posttranslational modification] 1016998012415 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1016998012416 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1016998012417 hypothetical protein; Provisional; Region: PRK10649 1016998012418 Sulfatase; Region: Sulfatase; pfam00884 1016998012419 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1016998012420 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1016998012421 acetylornithine deacetylase; Provisional; Region: PRK05111 1016998012422 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1016998012423 metal binding site [ion binding]; metal-binding site 1016998012424 putative dimer interface [polypeptide binding]; other site 1016998012425 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1016998012426 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1016998012427 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 1016998012428 nucleotide binding site [chemical binding]; other site 1016998012429 N-acetyl-L-glutamate binding site [chemical binding]; other site 1016998012430 argininosuccinate lyase; Provisional; Region: PRK04833 1016998012431 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1016998012432 active sites [active] 1016998012433 tetramer interface [polypeptide binding]; other site 1016998012434 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1016998012435 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998012436 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1016998012437 dimerization interface [polypeptide binding]; other site 1016998012438 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1016998012439 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1016998012440 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1016998012441 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1016998012442 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1016998012443 hypothetical protein; Provisional; Region: PRK11056 1016998012444 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 1016998012445 Protein of unknown function (DUF3164); Region: DUF3164; pfam11363 1016998012446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1016998012447 S-adenosylmethionine binding site [chemical binding]; other site 1016998012448 cobalamin riboswitch 1016998012449 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 1016998012450 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1016998012451 N-terminal plug; other site 1016998012452 ligand-binding site [chemical binding]; other site 1016998012453 glutamate racemase; Provisional; Region: PRK00865 1016998012454 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1016998012455 FAD binding domain; Region: FAD_binding_4; pfam01565 1016998012456 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1016998012457 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1016998012458 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1016998012459 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1016998012460 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1016998012461 pantothenate kinase; Provisional; Region: PRK05439 1016998012462 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1016998012463 ATP-binding site [chemical binding]; other site 1016998012464 CoA-binding site [chemical binding]; other site 1016998012465 Mg2+-binding site [ion binding]; other site 1016998012466 elongation factor Tu; Reviewed; Region: PRK00049 1016998012467 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1016998012468 G1 box; other site 1016998012469 GEF interaction site [polypeptide binding]; other site 1016998012470 GTP/Mg2+ binding site [chemical binding]; other site 1016998012471 Switch I region; other site 1016998012472 G2 box; other site 1016998012473 G3 box; other site 1016998012474 Switch II region; other site 1016998012475 G4 box; other site 1016998012476 G5 box; other site 1016998012477 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1016998012478 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1016998012479 Antibiotic Binding Site [chemical binding]; other site 1016998012480 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1016998012481 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1016998012482 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1016998012483 putative homodimer interface [polypeptide binding]; other site 1016998012484 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1016998012485 heterodimer interface [polypeptide binding]; other site 1016998012486 homodimer interface [polypeptide binding]; other site 1016998012487 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1016998012488 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1016998012489 23S rRNA interface [nucleotide binding]; other site 1016998012490 L7/L12 interface [polypeptide binding]; other site 1016998012491 putative thiostrepton binding site; other site 1016998012492 L25 interface [polypeptide binding]; other site 1016998012493 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1016998012494 mRNA/rRNA interface [nucleotide binding]; other site 1016998012495 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1016998012496 23S rRNA interface [nucleotide binding]; other site 1016998012497 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1016998012498 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1016998012499 core dimer interface [polypeptide binding]; other site 1016998012500 peripheral dimer interface [polypeptide binding]; other site 1016998012501 L10 interface [polypeptide binding]; other site 1016998012502 L11 interface [polypeptide binding]; other site 1016998012503 putative EF-Tu interaction site [polypeptide binding]; other site 1016998012504 putative EF-G interaction site [polypeptide binding]; other site 1016998012505 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1016998012506 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1016998012507 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1016998012508 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1016998012509 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1016998012510 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1016998012511 RPB3 interaction site [polypeptide binding]; other site 1016998012512 RPB1 interaction site [polypeptide binding]; other site 1016998012513 RPB11 interaction site [polypeptide binding]; other site 1016998012514 RPB10 interaction site [polypeptide binding]; other site 1016998012515 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1016998012516 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1016998012517 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1016998012518 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1016998012519 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1016998012520 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1016998012521 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1016998012522 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1016998012523 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1016998012524 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1016998012525 DNA binding site [nucleotide binding] 1016998012526 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1016998012527 type III secretion system protein; Provisional; Region: PRK15384 1016998012528 non-LEE encoded effector protein NleB; Provisional; Region: PRK15382 1016998012529 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 1016998012530 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1016998012531 FeS/SAM binding site; other site 1016998012532 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1016998012533 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1016998012534 ThiS interaction site; other site 1016998012535 putative active site [active] 1016998012536 tetramer interface [polypeptide binding]; other site 1016998012537 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1016998012538 thiS-thiF/thiG interaction site; other site 1016998012539 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1016998012540 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 1016998012541 ATP binding site [chemical binding]; other site 1016998012542 substrate interface [chemical binding]; other site 1016998012543 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1016998012544 thiamine phosphate binding site [chemical binding]; other site 1016998012545 active site 1016998012546 pyrophosphate binding site [ion binding]; other site 1016998012547 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1016998012548 ThiC-associated domain; Region: ThiC-associated; pfam13667 1016998012549 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1016998012550 TPP riboswitch (THI element) 1016998012551 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 1016998012552 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1016998012553 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1016998012554 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1016998012555 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1016998012556 putative NADH binding site [chemical binding]; other site 1016998012557 putative active site [active] 1016998012558 nudix motif; other site 1016998012559 putative metal binding site [ion binding]; other site 1016998012560 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1016998012561 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1016998012562 substrate binding site [chemical binding]; other site 1016998012563 active site 1016998012564 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1016998012565 Active_site [active] 1016998012566 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 1016998012567 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1016998012568 IHF dimer interface [polypeptide binding]; other site 1016998012569 IHF - DNA interface [nucleotide binding]; other site 1016998012570 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 1016998012571 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1016998012572 dimer interface [polypeptide binding]; other site 1016998012573 sensor protein ZraS; Provisional; Region: PRK10364 1016998012574 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1016998012575 dimer interface [polypeptide binding]; other site 1016998012576 phosphorylation site [posttranslational modification] 1016998012577 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1016998012578 ATP binding site [chemical binding]; other site 1016998012579 Mg2+ binding site [ion binding]; other site 1016998012580 G-X-G motif; other site 1016998012581 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 1016998012582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1016998012583 active site 1016998012584 phosphorylation site [posttranslational modification] 1016998012585 intermolecular recognition site; other site 1016998012586 dimerization interface [polypeptide binding]; other site 1016998012587 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1016998012588 Walker A motif; other site 1016998012589 ATP binding site [chemical binding]; other site 1016998012590 Walker B motif; other site 1016998012591 arginine finger; other site 1016998012592 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1016998012593 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1016998012594 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1016998012595 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1016998012596 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1016998012597 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1016998012598 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1016998012599 purine monophosphate binding site [chemical binding]; other site 1016998012600 dimer interface [polypeptide binding]; other site 1016998012601 putative catalytic residues [active] 1016998012602 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1016998012603 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1016998012604 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1016998012605 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1016998012606 Coenzyme A binding pocket [chemical binding]; other site 1016998012607 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1016998012608 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1016998012609 proposed active site lysine [active] 1016998012610 conserved cys residue [active] 1016998012611 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 1016998012612 malate synthase A; Region: malate_syn_A; TIGR01344 1016998012613 active site 1016998012614 isocitrate lyase; Provisional; Region: PRK15063 1016998012615 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1016998012616 tetramer interface [polypeptide binding]; other site 1016998012617 active site 1016998012618 Mg2+/Mn2+ binding site [ion binding]; other site 1016998012619 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 1016998012620 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 1016998012621 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1016998012622 transcriptional repressor IclR; Provisional; Region: PRK11569 1016998012623 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1016998012624 Bacterial transcriptional regulator; Region: IclR; pfam01614 1016998012625 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1016998012626 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1016998012627 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1016998012628 substrate binding pocket [chemical binding]; other site 1016998012629 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1016998012630 B12 binding site [chemical binding]; other site 1016998012631 cobalt ligand [ion binding]; other site 1016998012632 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1016998012633 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1016998012634 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1016998012635 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1016998012636 active site pocket [active] 1016998012637 oxyanion hole [active] 1016998012638 catalytic triad [active] 1016998012639 active site nucleophile [active] 1016998012640 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 1016998012641 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 1016998012642 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1016998012643 RNA binding surface [nucleotide binding]; other site 1016998012644 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 1016998012645 probable active site [active] 1016998012646 hypothetical protein; Provisional; Region: PRK10515 1016998012647 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1016998012648 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1016998012649 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1016998012650 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1016998012651 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1016998012652 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1016998012653 active site 1016998012654 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1016998012655 phosphate binding site [ion binding]; other site 1016998012656 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1016998012657 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1016998012658 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1016998012659 trimer interface [polypeptide binding]; other site 1016998012660 active site 1016998012661 substrate binding site [chemical binding]; other site 1016998012662 CoA binding site [chemical binding]; other site 1016998012663 Mor transcription activator family; Region: Mor; pfam08765 1016998012664 aspartate kinase III; Validated; Region: PRK09084 1016998012665 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1016998012666 nucleotide binding site [chemical binding]; other site 1016998012667 substrate binding site [chemical binding]; other site 1016998012668 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1016998012669 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 1016998012670 dimer interface [polypeptide binding]; other site 1016998012671 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1016998012672 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1016998012673 active site 1016998012674 dimer interface [polypeptide binding]; other site 1016998012675 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1016998012676 dimer interface [polypeptide binding]; other site 1016998012677 active site 1016998012678 Exopolysaccharide production protein YjbE; Region: YjbE; pfam11106 1016998012679 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 1016998012680 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 1016998012681 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 1016998012682 Predicted membrane protein [Function unknown]; Region: COG3223 1016998012683 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1016998012684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998012685 dimer interface [polypeptide binding]; other site 1016998012686 conserved gate region; other site 1016998012687 putative PBP binding loops; other site 1016998012688 ABC-ATPase subunit interface; other site 1016998012689 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1016998012690 dimer interface [polypeptide binding]; other site 1016998012691 conserved gate region; other site 1016998012692 putative PBP binding loops; other site 1016998012693 ABC-ATPase subunit interface; other site 1016998012694 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 1016998012695 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1016998012696 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1016998012697 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 1016998012698 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1016998012699 Walker A/P-loop; other site 1016998012700 ATP binding site [chemical binding]; other site 1016998012701 Q-loop/lid; other site 1016998012702 ABC transporter signature motif; other site 1016998012703 Walker B; other site 1016998012704 D-loop; other site 1016998012705 H-loop/switch region; other site 1016998012706 TOBE domain; Region: TOBE_2; pfam08402 1016998012707 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1016998012708 trimer interface; other site 1016998012709 sugar binding site [chemical binding]; other site 1016998012710 maltose regulon periplasmic protein; Provisional; Region: PRK10564 1016998012711 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 1016998012712 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1016998012713 UbiA prenyltransferase family; Region: UbiA; pfam01040 1016998012714 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 1016998012715 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1016998012716 putative acyl-acceptor binding pocket; other site 1016998012717 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1016998012718 LexA repressor; Validated; Region: PRK00215 1016998012719 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1016998012720 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1016998012721 Catalytic site [active] 1016998012722 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 1016998012723 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1016998012724 hypothetical protein; Provisional; Region: PRK10428 1016998012725 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1016998012726 metal binding site 2 [ion binding]; metal-binding site 1016998012727 putative DNA binding helix; other site 1016998012728 metal binding site 1 [ion binding]; metal-binding site 1016998012729 dimer interface [polypeptide binding]; other site 1016998012730 structural Zn2+ binding site [ion binding]; other site 1016998012731 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 1016998012732 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1016998012733 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1016998012734 FMN binding site [chemical binding]; other site 1016998012735 active site 1016998012736 catalytic residues [active] 1016998012737 substrate binding site [chemical binding]; other site 1016998012738 phage shock protein G; Reviewed; Region: pspG; PRK09459 1016998012739 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1016998012740 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1016998012741 NADP binding site [chemical binding]; other site 1016998012742 dimer interface [polypeptide binding]; other site 1016998012743 replicative DNA helicase; Provisional; Region: PRK08006 1016998012744 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1016998012745 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1016998012746 Walker A motif; other site 1016998012747 ATP binding site [chemical binding]; other site 1016998012748 Walker B motif; other site 1016998012749 DNA binding loops [nucleotide binding] 1016998012750 alanine racemase; Reviewed; Region: alr; PRK00053 1016998012751 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1016998012752 active site 1016998012753 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1016998012754 substrate binding site [chemical binding]; other site 1016998012755 catalytic residues [active] 1016998012756 dimer interface [polypeptide binding]; other site 1016998012757 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1016998012758 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1016998012759 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998012760 homodimer interface [polypeptide binding]; other site 1016998012761 catalytic residue [active] 1016998012762 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1016998012763 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1016998012764 active site 1016998012765 motif I; other site 1016998012766 motif II; other site 1016998012767 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1016998012768 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1016998012769 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1016998012770 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1016998012771 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1016998012772 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1016998012773 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1016998012774 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1016998012775 dimer interface [polypeptide binding]; other site 1016998012776 ssDNA binding site [nucleotide binding]; other site 1016998012777 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1016998012778 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1016998012779 hypothetical protein; Validated; Region: PRK09039 1016998012780 Zinc finger-containing protein; Region: zf-C4H2; pfam10146 1016998012781 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1016998012782 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1016998012783 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1016998012784 HlyD family secretion protein; Region: HlyD_3; pfam13437 1016998012785 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1016998012786 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1016998012787 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1016998012788 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1016998012789 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1016998012790 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1016998012791 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1016998012792 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1016998012793 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1016998012794 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1016998012795 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1016998012796 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1016998012797 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1016998012798 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1016998012799 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1016998012800 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1016998012801 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1016998012802 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1016998012803 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1016998012804 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1016998012805 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1016998012806 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1016998012807 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1016998012808 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1016998012809 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1016998012810 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1016998012811 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1016998012812 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1016998012813 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1016998012814 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1016998012815 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1016998012816 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1016998012817 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1016998012818 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1016998012819 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1016998012820 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1016998012821 Bacterial Ig-like domain (group 3); Region: Big_3_2; pfam12245 1016998012822 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1016998012823 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1016998012824 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1016998012825 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1016998012826 Walker A/P-loop; other site 1016998012827 ATP binding site [chemical binding]; other site 1016998012828 Q-loop/lid; other site 1016998012829 ABC transporter signature motif; other site 1016998012830 Walker B; other site 1016998012831 D-loop; other site 1016998012832 H-loop/switch region; other site 1016998012833 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1016998012834 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1016998012835 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1016998012836 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1016998012837 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1016998012838 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 1016998012839 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 1016998012840 DNA binding residues [nucleotide binding] 1016998012841 dimer interface [polypeptide binding]; other site 1016998012842 [2Fe-2S] cluster binding site [ion binding]; other site 1016998012843 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1016998012844 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1016998012845 putative C-terminal domain interface [polypeptide binding]; other site 1016998012846 putative GSH binding site (G-site) [chemical binding]; other site 1016998012847 putative dimer interface [polypeptide binding]; other site 1016998012848 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 1016998012849 putative N-terminal domain interface [polypeptide binding]; other site 1016998012850 putative dimer interface [polypeptide binding]; other site 1016998012851 putative substrate binding pocket (H-site) [chemical binding]; other site 1016998012852 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1016998012853 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1016998012854 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998012855 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1016998012856 putative dimerization interface [polypeptide binding]; other site 1016998012857 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1016998012858 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1016998012859 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1016998012860 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1016998012861 Na binding site [ion binding]; other site 1016998012862 Predicted membrane protein [Function unknown]; Region: COG3162 1016998012863 acetyl-CoA synthetase; Provisional; Region: PRK00174 1016998012864 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1016998012865 active site 1016998012866 CoA binding site [chemical binding]; other site 1016998012867 acyl-activating enzyme (AAE) consensus motif; other site 1016998012868 AMP binding site [chemical binding]; other site 1016998012869 acetate binding site [chemical binding]; other site 1016998012870 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 1016998012871 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 1016998012872 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 1016998012873 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 1016998012874 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 1016998012875 heme lyase subunit NrfE; Provisional; Region: PRK10369 1016998012876 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 1016998012877 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 1016998012878 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 1016998012879 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1016998012880 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1016998012881 Sel1-like repeats; Region: SEL1; smart00671 1016998012882 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 1016998012883 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1016998012884 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1016998012885 Coenzyme A binding pocket [chemical binding]; other site 1016998012886 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1016998012887 dimer interface [polypeptide binding]; other site 1016998012888 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1016998012889 hypothetical protein; Provisional; Region: PRK10220 1016998012890 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1016998012891 PhnA protein; Region: PhnA; pfam03831 1016998012892 proline/glycine betaine transporter; Provisional; Region: PRK10642 1016998012893 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998012894 putative substrate translocation pore; other site 1016998012895 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 1016998012896 sensor protein BasS/PmrB; Provisional; Region: PRK10755 1016998012897 HAMP domain; Region: HAMP; pfam00672 1016998012898 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1016998012899 dimer interface [polypeptide binding]; other site 1016998012900 phosphorylation site [posttranslational modification] 1016998012901 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1016998012902 ATP binding site [chemical binding]; other site 1016998012903 Mg2+ binding site [ion binding]; other site 1016998012904 G-X-G motif; other site 1016998012905 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1016998012906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1016998012907 active site 1016998012908 phosphorylation site [posttranslational modification] 1016998012909 intermolecular recognition site; other site 1016998012910 dimerization interface [polypeptide binding]; other site 1016998012911 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1016998012912 DNA binding site [nucleotide binding] 1016998012913 putative metal dependent hydrolase; Provisional; Region: PRK11598 1016998012914 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1016998012915 Sulfatase; Region: Sulfatase; pfam00884 1016998012916 arginine:agmatin antiporter; Provisional; Region: PRK10644 1016998012917 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 1016998012918 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1016998012919 arginine decarboxylase; Provisional; Region: PRK15029 1016998012920 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1016998012921 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1016998012922 homodimer interface [polypeptide binding]; other site 1016998012923 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1016998012924 catalytic residue [active] 1016998012925 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1016998012926 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 1016998012927 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1016998012928 alpha-galactosidase; Provisional; Region: PRK15076 1016998012929 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1016998012930 NAD binding site [chemical binding]; other site 1016998012931 sugar binding site [chemical binding]; other site 1016998012932 divalent metal binding site [ion binding]; other site 1016998012933 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1016998012934 dimer interface [polypeptide binding]; other site 1016998012935 melibiose:sodium symporter; Provisional; Region: PRK10429 1016998012936 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1016998012937 fumarate hydratase; Provisional; Region: PRK15389 1016998012938 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 1016998012939 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1016998012940 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1016998012941 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 1016998012942 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 1016998012943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1016998012944 active site 1016998012945 phosphorylation site [posttranslational modification] 1016998012946 intermolecular recognition site; other site 1016998012947 dimerization interface [polypeptide binding]; other site 1016998012948 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1016998012949 PAS domain; Region: PAS; smart00091 1016998012950 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1016998012951 ATP binding site [chemical binding]; other site 1016998012952 Mg2+ binding site [ion binding]; other site 1016998012953 G-X-G motif; other site 1016998012954 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1016998012955 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1016998012956 putative [Fe4-S4] binding site [ion binding]; other site 1016998012957 putative molybdopterin cofactor binding site [chemical binding]; other site 1016998012958 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1016998012959 putative molybdopterin cofactor binding site; other site 1016998012960 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1016998012961 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 1016998012962 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 1016998012963 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 1016998012964 SdiA-regulated; Region: SdiA-regulated; pfam06977 1016998012965 SdiA-regulated; Region: SdiA-regulated; cd09971 1016998012966 putative active site [active] 1016998012967 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1016998012968 Walker A/P-loop; other site 1016998012969 ATP binding site [chemical binding]; other site 1016998012970 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1016998012971 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1016998012972 DNA binding residues [nucleotide binding] 1016998012973 dimerization interface [polypeptide binding]; other site 1016998012974 AraC family transcriptional regulator; Provisional; Region: PRK15186 1016998012975 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1016998012976 Integrase core domain; Region: rve_3; cl15866 1016998012977 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 1016998012978 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1016998012979 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 1016998012980 active site 1016998012981 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1016998012982 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1016998012983 P-loop; other site 1016998012984 Magnesium ion binding site [ion binding]; other site 1016998012985 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1016998012986 replicative DNA helicase; Region: DnaB; TIGR00665 1016998012987 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1016998012988 Walker A motif; other site 1016998012989 ATP binding site [chemical binding]; other site 1016998012990 Walker B motif; other site 1016998012991 DNA binding loops [nucleotide binding] 1016998012992 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 1016998012993 ParB-like nuclease domain; Region: ParBc; pfam02195 1016998012994 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1016998012995 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 1016998012996 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 1016998012997 Helix-turn-helix domain; Region: HTH_36; pfam13730 1016998012998 Domain of unknown function (DUF1845); Region: DUF1845; pfam08900 1016998012999 DNA topoisomerase III; Provisional; Region: PRK07726 1016998013000 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1016998013001 active site 1016998013002 putative interdomain interaction site [polypeptide binding]; other site 1016998013003 putative metal-binding site [ion binding]; other site 1016998013004 putative nucleotide binding site [chemical binding]; other site 1016998013005 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1016998013006 domain I; other site 1016998013007 DNA binding groove [nucleotide binding] 1016998013008 phosphate binding site [ion binding]; other site 1016998013009 domain II; other site 1016998013010 domain III; other site 1016998013011 nucleotide binding site [chemical binding]; other site 1016998013012 catalytic site [active] 1016998013013 domain IV; other site 1016998013014 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1016998013015 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 1016998013016 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1016998013017 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1016998013018 dimer interface [polypeptide binding]; other site 1016998013019 ssDNA binding site [nucleotide binding]; other site 1016998013020 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1016998013021 putative single-stranded DNA-binding protein; Region: PHA01740 1016998013022 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 1016998013023 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 1016998013024 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 1016998013025 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 1016998013026 PilM; Region: PilM; pfam07419 1016998013027 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 1016998013028 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1016998013029 Pilin accessory protein (PilO); Region: PAP_PilO; pfam06864 1016998013030 type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021 1016998013031 Type II/IV secretion system protein; Region: T2SE; pfam00437 1016998013032 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1016998013033 Walker A motif; other site 1016998013034 ATP binding site [chemical binding]; other site 1016998013035 Walker B motif; other site 1016998013036 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1016998013037 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1016998013038 PilS N terminal; Region: PilS; pfam08805 1016998013039 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1016998013040 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1016998013041 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1016998013042 catalytic residue [active] 1016998013043 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 1016998013044 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1016998013045 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1016998013046 active site 1016998013047 DNA binding site [nucleotide binding] 1016998013048 Int/Topo IB signature motif; other site 1016998013049 Protein of unknown function (DUF3584); Region: DUF3584; pfam12128 1016998013050 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 1016998013051 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1016998013052 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1016998013053 integrating conjugative element protein, PFL_4695 family; Region: ICE_PFL_4695; TIGR03765 1016998013054 Restriction endonuclease; Region: Mrr_cat; pfam04471 1016998013055 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 1016998013056 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 1016998013057 Domain of unknown function (DUF4400); Region: DUF4400; cl14023 1016998013058 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 1016998013059 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 1016998013060 Protein of unknown function (DUF3262); Region: DUF3262; pfam11660 1016998013061 integrating conjugative element membrane protein, PFL_4702 family; Region: conj_TIGR03745 1016998013062 conjugative transfer region protein, TIGR03750 family; Region: conj_TIGR03750 1016998013063 integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746 1016998013064 Protein of unknown function (DUF3438); Region: DUF3438; pfam11920 1016998013065 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 1016998013066 MbeD/MobD like; Region: MbeD_MobD; pfam04899 1016998013067 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 1016998013068 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 1016998013069 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 1016998013070 Protein of unknown function (DUF1525); Region: DUF1525; pfam07511 1016998013071 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 1016998013072 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 1016998013073 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 1016998013074 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 1016998013075 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1016998013076 Coenzyme A binding pocket [chemical binding]; other site 1016998013077 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 1016998013078 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 1016998013079 Phage terminase small subunit; Region: Phage_terminase; pfam10668 1016998013080 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1016998013081 Domain of unknown function DUF87; Region: DUF87; pfam01935 1016998013082 HerA helicase [Replication, recombination, and repair]; Region: COG0433 1016998013083 Helix-turn-helix domain; Region: HTH_20; pfam12840 1016998013084 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1016998013085 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1016998013086 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1016998013087 RNA polymerase sigma factor, SigZ family; Region: SigZ; TIGR02959 1016998013088 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1016998013089 DNA binding residues [nucleotide binding] 1016998013090 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 1016998013091 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 1016998013092 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1016998013093 P loop; other site 1016998013094 Nucleotide binding site [chemical binding]; other site 1016998013095 DTAP/Switch II; other site 1016998013096 Switch I; other site 1016998013097 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1016998013098 DTAP/Switch II; other site 1016998013099 Switch I; other site 1016998013100 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1016998013101 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1016998013102 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1016998013103 Coenzyme A binding pocket [chemical binding]; other site 1016998013104 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1016998013105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998013106 putative substrate translocation pore; other site 1016998013107 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1016998013108 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1016998013109 active site 1016998013110 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1016998013111 ArsC family; Region: ArsC; pfam03960 1016998013112 catalytic residues [active] 1016998013113 arsenical pump membrane protein; Provisional; Region: PRK15445 1016998013114 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1016998013115 transmembrane helices; other site 1016998013116 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 1016998013117 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1016998013118 P loop; other site 1016998013119 Nucleotide binding site [chemical binding]; other site 1016998013120 DTAP/Switch II; other site 1016998013121 Switch I; other site 1016998013122 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1016998013123 P loop; other site 1016998013124 Nucleotide binding site [chemical binding]; other site 1016998013125 DTAP/Switch II; other site 1016998013126 Switch I; other site 1016998013127 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 1016998013128 Domain of unknown function (DUF2703); Region: DUF2703; pfam10865 1016998013129 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 1016998013130 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1016998013131 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1016998013132 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 1016998013133 Integrase; Region: Integrase_1; pfam12835 1016998013134 Protein of unknown function (DUF3085); Region: DUF3085; pfam11284 1016998013135 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 1016998013136 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 1016998013137 Protein of unknown function (DUF1281); Region: DUF1281; pfam06924 1016998013138 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 1016998013139 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1016998013140 Spc7 kinetochore protein; Region: Spc7; pfam08317 1016998013141 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 1016998013142 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 1016998013143 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 1016998013144 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1016998013145 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1016998013146 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1016998013147 active site 1016998013148 catalytic residues [active] 1016998013149 DNA binding site [nucleotide binding] 1016998013150 Int/Topo IB signature motif; other site 1016998013151 putative transcriptional regulator; Provisional; Region: PRK11640 1016998013152 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1016998013153 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1016998013154 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1016998013155 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1016998013156 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1016998013157 DsbD alpha interface [polypeptide binding]; other site 1016998013158 catalytic residues [active] 1016998013159 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 1016998013160 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1016998013161 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1016998013162 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1016998013163 Aspartase; Region: Aspartase; cd01357 1016998013164 active sites [active] 1016998013165 tetramer interface [polypeptide binding]; other site 1016998013166 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 1016998013167 putative transporter; Provisional; Region: PRK11021 1016998013168 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1016998013169 oligomerisation interface [polypeptide binding]; other site 1016998013170 mobile loop; other site 1016998013171 roof hairpin; other site 1016998013172 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1016998013173 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1016998013174 ring oligomerisation interface [polypeptide binding]; other site 1016998013175 ATP/Mg binding site [chemical binding]; other site 1016998013176 stacking interactions; other site 1016998013177 hinge regions; other site 1016998013178 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 1016998013179 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1016998013180 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1016998013181 FeS/SAM binding site; other site 1016998013182 elongation factor P; Validated; Region: PRK00529 1016998013183 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1016998013184 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1016998013185 RNA binding site [nucleotide binding]; other site 1016998013186 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1016998013187 RNA binding site [nucleotide binding]; other site 1016998013188 Predicted small secreted protein [Function unknown]; Region: COG5510 1016998013189 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1016998013190 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1016998013191 DNA binding residues [nucleotide binding] 1016998013192 dimerization interface [polypeptide binding]; other site 1016998013193 multidrug efflux system protein; Provisional; Region: PRK11431 1016998013194 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 1016998013195 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1016998013196 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 1016998013197 Iron-sulfur protein interface; other site 1016998013198 proximal quinone binding site [chemical binding]; other site 1016998013199 C-subunit interface; other site 1016998013200 distal quinone binding site; other site 1016998013201 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 1016998013202 D-subunit interface [polypeptide binding]; other site 1016998013203 Iron-sulfur protein interface; other site 1016998013204 proximal quinone binding site [chemical binding]; other site 1016998013205 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 1016998013206 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1016998013207 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 1016998013208 L-aspartate oxidase; Provisional; Region: PRK06175 1016998013209 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1016998013210 poxB regulator PoxA; Provisional; Region: PRK09350 1016998013211 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1016998013212 motif 1; other site 1016998013213 dimer interface [polypeptide binding]; other site 1016998013214 active site 1016998013215 motif 2; other site 1016998013216 motif 3; other site 1016998013217 inner membrane transporter YjeM; Provisional; Region: PRK15238 1016998013218 Protein of unknown function (DUF2645); Region: DUF2645; pfam10840 1016998013219 putative mechanosensitive channel protein; Provisional; Region: PRK10929 1016998013220 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1016998013221 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1016998013222 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1016998013223 GTPase RsgA; Reviewed; Region: PRK12288 1016998013224 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1016998013225 RNA binding site [nucleotide binding]; other site 1016998013226 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1016998013227 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1016998013228 GTP/Mg2+ binding site [chemical binding]; other site 1016998013229 G4 box; other site 1016998013230 G5 box; other site 1016998013231 G1 box; other site 1016998013232 Switch I region; other site 1016998013233 G2 box; other site 1016998013234 G3 box; other site 1016998013235 Switch II region; other site 1016998013236 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1016998013237 catalytic site [active] 1016998013238 putative active site [active] 1016998013239 putative substrate binding site [chemical binding]; other site 1016998013240 dimer interface [polypeptide binding]; other site 1016998013241 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1016998013242 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1016998013243 substrate binding pocket [chemical binding]; other site 1016998013244 membrane-bound complex binding site; other site 1016998013245 hinge residues; other site 1016998013246 epoxyqueuosine reductase; Region: TIGR00276 1016998013247 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1016998013248 putative carbohydrate kinase; Provisional; Region: PRK10565 1016998013249 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1016998013250 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1016998013251 putative substrate binding site [chemical binding]; other site 1016998013252 putative ATP binding site [chemical binding]; other site 1016998013253 ADP-binding protein; Provisional; Region: PRK10646 1016998013254 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 1016998013255 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1016998013256 active site 1016998013257 metal binding site [ion binding]; metal-binding site 1016998013258 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1016998013259 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1016998013260 ATP binding site [chemical binding]; other site 1016998013261 Mg2+ binding site [ion binding]; other site 1016998013262 G-X-G motif; other site 1016998013263 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1016998013264 ATP binding site [chemical binding]; other site 1016998013265 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1016998013266 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1016998013267 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1016998013268 bacterial Hfq-like; Region: Hfq; cd01716 1016998013269 hexamer interface [polypeptide binding]; other site 1016998013270 Sm1 motif; other site 1016998013271 RNA binding site [nucleotide binding]; other site 1016998013272 Sm2 motif; other site 1016998013273 GTPase HflX; Provisional; Region: PRK11058 1016998013274 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1016998013275 HflX GTPase family; Region: HflX; cd01878 1016998013276 G1 box; other site 1016998013277 GTP/Mg2+ binding site [chemical binding]; other site 1016998013278 Switch I region; other site 1016998013279 G2 box; other site 1016998013280 G3 box; other site 1016998013281 Switch II region; other site 1016998013282 G4 box; other site 1016998013283 G5 box; other site 1016998013284 FtsH protease regulator HflK; Provisional; Region: PRK10930 1016998013285 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 1016998013286 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1016998013287 FtsH protease regulator HflC; Provisional; Region: PRK11029 1016998013288 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1016998013289 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 1016998013290 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1016998013291 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1016998013292 GDP-binding site [chemical binding]; other site 1016998013293 ACT binding site; other site 1016998013294 IMP binding site; other site 1016998013295 Predicted transcriptional regulator [Transcription]; Region: COG1959 1016998013296 transcriptional repressor NsrR; Provisional; Region: PRK11014 1016998013297 exoribonuclease R; Provisional; Region: PRK11642 1016998013298 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1016998013299 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1016998013300 RNB domain; Region: RNB; pfam00773 1016998013301 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1016998013302 RNA binding site [nucleotide binding]; other site 1016998013303 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1016998013304 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1016998013305 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1016998013306 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 1016998013307 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1016998013308 Ion channel; Region: Ion_trans_2; pfam07885 1016998013309 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1016998013310 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 1016998013311 Predicted membrane protein [Function unknown]; Region: COG3766 1016998013312 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1016998013313 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1016998013314 Predicted integral membrane protein [Function unknown]; Region: COG5463 1016998013315 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1016998013316 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1016998013317 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 1016998013318 FAD binding site [chemical binding]; other site 1016998013319 substrate binding site [chemical binding]; other site 1016998013320 catalytic residues [active] 1016998013321 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1016998013322 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 1016998013323 esterase; Provisional; Region: PRK10566 1016998013324 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1016998013325 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1016998013326 transcriptional repressor UlaR; Provisional; Region: PRK13509 1016998013327 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1016998013328 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1016998013329 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 1016998013330 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1016998013331 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 1016998013332 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 1016998013333 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1016998013334 active site 1016998013335 P-loop; other site 1016998013336 phosphorylation site [posttranslational modification] 1016998013337 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1016998013338 active site 1016998013339 phosphorylation site [posttranslational modification] 1016998013340 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1016998013341 active site 1016998013342 dimer interface [polypeptide binding]; other site 1016998013343 magnesium binding site [ion binding]; other site 1016998013344 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 1016998013345 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1016998013346 AP (apurinic/apyrimidinic) site pocket; other site 1016998013347 DNA interaction; other site 1016998013348 Metal-binding active site; metal-binding site 1016998013349 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1016998013350 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1016998013351 intersubunit interface [polypeptide binding]; other site 1016998013352 active site 1016998013353 Zn2+ binding site [ion binding]; other site 1016998013354 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1016998013355 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1016998013356 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1016998013357 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1016998013358 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1016998013359 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1016998013360 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1016998013361 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1016998013362 EamA-like transporter family; Region: EamA; pfam00892 1016998013363 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 1016998013364 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 1016998013365 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 1016998013366 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1016998013367 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1016998013368 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1016998013369 DKNYY family; Region: DKNYY; pfam13644 1016998013370 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 1016998013371 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1016998013372 Hemerythrin-like domain; Region: Hr-like; cd12108 1016998013373 Fe binding site [ion binding]; other site 1016998013374 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1016998013375 EamA-like transporter family; Region: EamA; pfam00892 1016998013376 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1016998013377 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1016998013378 NADP binding site [chemical binding]; other site 1016998013379 Predicted transcriptional regulators [Transcription]; Region: COG1733 1016998013380 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1016998013381 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 1016998013382 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1016998013383 active site 1016998013384 metal binding site [ion binding]; metal-binding site 1016998013385 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1016998013386 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1016998013387 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1016998013388 active site 1016998013389 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 1016998013390 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 1016998013391 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1016998013392 Domain of unknown function DUF21; Region: DUF21; pfam01595 1016998013393 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1016998013394 Transporter associated domain; Region: CorC_HlyC; smart01091 1016998013395 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1016998013396 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1016998013397 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1016998013398 Surface antigen; Region: Bac_surface_Ag; pfam01103 1016998013399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1016998013400 Family of unknown function (DUF490); Region: DUF490; pfam04357 1016998013401 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1016998013402 dimerization interface [polypeptide binding]; other site 1016998013403 putative active site pocket [active] 1016998013404 putative catalytic residue [active] 1016998013405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998013406 D-galactonate transporter; Region: 2A0114; TIGR00893 1016998013407 putative substrate translocation pore; other site 1016998013408 putative metallo-dependent hydrolase; Provisional; Region: PRK12394 1016998013409 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 1016998013410 active site 1016998013411 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1016998013412 dimer interface [polypeptide binding]; other site 1016998013413 substrate binding site [chemical binding]; other site 1016998013414 metal binding sites [ion binding]; metal-binding site 1016998013415 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1016998013416 AMP binding site [chemical binding]; other site 1016998013417 metal binding site [ion binding]; metal-binding site 1016998013418 active site 1016998013419 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1016998013420 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1016998013421 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1016998013422 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1016998013423 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1016998013424 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1016998013425 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1016998013426 putative active site [active] 1016998013427 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1016998013428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998013429 putative substrate translocation pore; other site 1016998013430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998013431 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1016998013432 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998013433 putative substrate translocation pore; other site 1016998013434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998013435 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 1016998013436 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1016998013437 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1016998013438 tetrameric interface [polypeptide binding]; other site 1016998013439 NAD binding site [chemical binding]; other site 1016998013440 catalytic residues [active] 1016998013441 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1016998013442 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1016998013443 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1016998013444 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1016998013445 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1016998013446 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1016998013447 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1016998013448 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1016998013449 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1016998013450 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1016998013451 major facilitator superfamily transporter; Provisional; Region: PRK05122 1016998013452 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998013453 putative substrate translocation pore; other site 1016998013454 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1016998013455 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1016998013456 substrate binding site [chemical binding]; other site 1016998013457 ATP binding site [chemical binding]; other site 1016998013458 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 1016998013459 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 1016998013460 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1016998013461 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1016998013462 PYR/PP interface [polypeptide binding]; other site 1016998013463 dimer interface [polypeptide binding]; other site 1016998013464 TPP binding site [chemical binding]; other site 1016998013465 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1016998013466 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1016998013467 TPP-binding site; other site 1016998013468 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1016998013469 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1016998013470 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1016998013471 polyol permease family; Region: 2A0118; TIGR00897 1016998013472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998013473 putative substrate translocation pore; other site 1016998013474 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 1016998013475 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1016998013476 DNA interaction; other site 1016998013477 Metal-binding active site; metal-binding site 1016998013478 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1016998013479 hypothetical protein; Provisional; Region: PRK05255 1016998013480 peptidase PmbA; Provisional; Region: PRK11040 1016998013481 cytochrome b562; Provisional; Region: PRK15058 1016998013482 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 1016998013483 conserved hypothetical protein EF_0830/AHA_3911; Region: EF_0830; TIGR03577 1016998013484 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 1016998013485 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 1016998013486 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 1016998013487 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 1016998013488 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 1016998013489 active site 1016998013490 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 1016998013491 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1016998013492 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 1016998013493 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1016998013494 HTH domain; Region: HTH_11; pfam08279 1016998013495 Mga helix-turn-helix domain; Region: Mga; pfam05043 1016998013496 PRD domain; Region: PRD; pfam00874 1016998013497 PRD domain; Region: PRD; pfam00874 1016998013498 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1016998013499 active site 1016998013500 P-loop; other site 1016998013501 phosphorylation site [posttranslational modification] 1016998013502 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1016998013503 active site 1016998013504 phosphorylation site [posttranslational modification] 1016998013505 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 1016998013506 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1016998013507 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1016998013508 4Fe-4S single cluster domain; Region: Fer4_14; pfam13394 1016998013509 FeS/SAM binding site; other site 1016998013510 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1016998013511 ATP cone domain; Region: ATP-cone; pfam03477 1016998013512 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1016998013513 effector binding site; other site 1016998013514 active site 1016998013515 Zn binding site [ion binding]; other site 1016998013516 glycine loop; other site 1016998013517 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 1016998013518 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1016998013519 Ca binding site [ion binding]; other site 1016998013520 active site 1016998013521 catalytic site [active] 1016998013522 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1016998013523 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 1016998013524 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1016998013525 active site turn [active] 1016998013526 phosphorylation site [posttranslational modification] 1016998013527 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1016998013528 trehalose repressor; Provisional; Region: treR; PRK09492 1016998013529 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1016998013530 DNA binding site [nucleotide binding] 1016998013531 domain linker motif; other site 1016998013532 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 1016998013533 dimerization interface [polypeptide binding]; other site 1016998013534 ligand binding site [chemical binding]; other site 1016998013535 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 1016998013536 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1016998013537 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1016998013538 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1016998013539 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1016998013540 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1016998013541 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1016998013542 Transposase; Region: HTH_Tnp_1; cl17663 1016998013543 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1016998013544 homotrimer interaction site [polypeptide binding]; other site 1016998013545 putative active site [active] 1016998013546 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 1016998013547 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 1016998013548 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 1016998013549 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 1016998013550 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1016998013551 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1016998013552 Arginine repressor [Transcription]; Region: ArgR; COG1438 1016998013553 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1016998013554 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1016998013555 Predicted membrane protein [Function unknown]; Region: COG1288 1016998013556 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1016998013557 ornithine carbamoyltransferase; Validated; Region: PRK02102 1016998013558 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1016998013559 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1016998013560 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1016998013561 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1016998013562 putative substrate binding site [chemical binding]; other site 1016998013563 nucleotide binding site [chemical binding]; other site 1016998013564 nucleotide binding site [chemical binding]; other site 1016998013565 homodimer interface [polypeptide binding]; other site 1016998013566 arginine deiminase; Provisional; Region: PRK01388 1016998013567 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1016998013568 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 1016998013569 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1016998013570 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1016998013571 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 1016998013572 RNase E inhibitor protein; Provisional; Region: PRK11191 1016998013573 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 1016998013574 active site 1016998013575 dinuclear metal binding site [ion binding]; other site 1016998013576 dimerization interface [polypeptide binding]; other site 1016998013577 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 1016998013578 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1016998013579 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1016998013580 Coenzyme A binding pocket [chemical binding]; other site 1016998013581 Predicted membrane protein [Function unknown]; Region: COG4269 1016998013582 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1016998013583 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1016998013584 HIGH motif; other site 1016998013585 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1016998013586 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1016998013587 active site 1016998013588 KMSKS motif; other site 1016998013589 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1016998013590 tRNA binding surface [nucleotide binding]; other site 1016998013591 anticodon binding site; other site 1016998013592 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1016998013593 DNA polymerase III subunit chi; Validated; Region: PRK05728 1016998013594 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1016998013595 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1016998013596 interface (dimer of trimers) [polypeptide binding]; other site 1016998013597 Substrate-binding/catalytic site; other site 1016998013598 Zn-binding sites [ion binding]; other site 1016998013599 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 1016998013600 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1016998013601 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 1016998013602 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1016998013603 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 1016998013604 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1016998013605 DNA binding site [nucleotide binding] 1016998013606 domain linker motif; other site 1016998013607 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1016998013608 putative dimerization interface [polypeptide binding]; other site 1016998013609 putative ligand binding site [chemical binding]; other site 1016998013610 gluconate transporter; Region: gntP; TIGR00791 1016998013611 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1016998013612 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 1016998013613 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1016998013614 NADP binding site [chemical binding]; other site 1016998013615 homodimer interface [polypeptide binding]; other site 1016998013616 active site 1016998013617 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 1016998013618 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 1016998013619 putative NAD(P) binding site [chemical binding]; other site 1016998013620 catalytic Zn binding site [ion binding]; other site 1016998013621 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1016998013622 ATP-binding site [chemical binding]; other site 1016998013623 Gluconate-6-phosphate binding site [chemical binding]; other site 1016998013624 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1016998013625 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1016998013626 putative NAD(P) binding site [chemical binding]; other site 1016998013627 putative substrate binding site [chemical binding]; other site 1016998013628 catalytic Zn binding site [ion binding]; other site 1016998013629 structural Zn binding site [ion binding]; other site 1016998013630 dimer interface [polypeptide binding]; other site 1016998013631 Winged helix-turn helix; Region: HTH_29; pfam13551 1016998013632 Homeodomain-like domain; Region: HTH_23; pfam13384 1016998013633 Homeodomain-like domain; Region: HTH_32; pfam13565 1016998013634 Methyltransferase domain; Region: Methyltransf_27; pfam13708 1016998013635 Predicted transcriptional regulator [Transcription]; Region: COG3905 1016998013636 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 1016998013637 CcdB protein; Region: CcdB; pfam01845 1016998013638 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1016998013639 Part of AAA domain; Region: AAA_19; pfam13245 1016998013640 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1016998013641 AAA domain; Region: AAA_12; pfam13087 1016998013642 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1016998013643 putative active site [active] 1016998013644 catalytic site [active] 1016998013645 DNA cytosine methylase; Provisional; Region: PRK10458 1016998013646 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1016998013647 cofactor binding site; other site 1016998013648 DNA binding site [nucleotide binding] 1016998013649 substrate interaction site [chemical binding]; other site 1016998013650 N-terminal domain of type IIE restriction endonuclease EcoRII and similar proteins; Region: EcoRII_N; cd10016 1016998013651 DNA binding site [nucleotide binding] 1016998013652 EcoRII C terminal; Region: EcoRII-C; pfam09019 1016998013653 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1016998013654 hypothetical protein; Provisional; Region: PRK12378 1016998013655 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1016998013656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1016998013657 S-adenosylmethionine binding site [chemical binding]; other site 1016998013658 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1016998013659 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1016998013660 S-adenosylmethionine binding site [chemical binding]; other site 1016998013661 hypothetical protein; Provisional; Region: PRK13687 1016998013662 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 1016998013663 Protein of unknown function DUF91; Region: DUF91; cl00709 1016998013664 Uncharacterized conserved protein [Function unknown]; Region: COG3439 1016998013665 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1016998013666 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 1016998013667 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1016998013668 DNA-binding site [nucleotide binding]; DNA binding site 1016998013669 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1016998013670 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1016998013671 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1016998013672 active site 1016998013673 HIGH motif; other site 1016998013674 dimer interface [polypeptide binding]; other site 1016998013675 KMSKS motif; other site 1016998013676 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 1016998013677 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1016998013678 aspartate racemase; Region: asp_race; TIGR00035 1016998013679 cell density-dependent motility repressor; Provisional; Region: PRK10082 1016998013680 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1016998013681 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1016998013682 dimerization interface [polypeptide binding]; other site 1016998013683 isoaspartyl dipeptidase; Provisional; Region: PRK10657 1016998013684 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1016998013685 active site 1016998013686 hypothetical protein; Provisional; Region: PRK10519 1016998013687 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1016998013688 Nucleoside recognition; Region: Gate; pfam07670 1016998013689 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 1016998013690 Predicted membrane protein [Function unknown]; Region: COG2733 1016998013691 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 1016998013692 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1016998013693 putative substrate translocation pore; other site 1016998013694 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1016998013695 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1016998013696 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1016998013697 NAD(P) binding site [chemical binding]; other site 1016998013698 catalytic residues [active] 1016998013699 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 1016998013700 endoribonuclease SymE; Provisional; Region: PRK13605 1016998013701 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 1016998013702 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1016998013703 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1016998013704 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1016998013705 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1016998013706 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1016998013707 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 1016998013708 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 1016998013709 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1016998013710 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1016998013711 ATP binding site [chemical binding]; other site 1016998013712 putative Mg++ binding site [ion binding]; other site 1016998013713 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 1016998013714 Mrr N-terminal domain; Region: Mrr_N; pfam14338 1016998013715 Restriction endonuclease; Region: Mrr_cat; pfam04471 1016998013716 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929 1016998013717 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514 1016998013718 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 1016998013719 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1016998013720 P-loop, Walker A motif; other site 1016998013721 Base recognition motif; other site 1016998013722 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1016998013723 Uncharacterized small protein [Function unknown]; Region: COG2879 1016998013724 carbon starvation protein A; Provisional; Region: PRK15015 1016998013725 Carbon starvation protein CstA; Region: CstA; pfam02554 1016998013726 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1016998013727 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1016998013728 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1016998013729 dimer interface [polypeptide binding]; other site 1016998013730 ligand binding site [chemical binding]; other site 1016998013731 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1016998013732 dimerization interface [polypeptide binding]; other site 1016998013733 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1016998013734 dimer interface [polypeptide binding]; other site 1016998013735 putative CheW interface [polypeptide binding]; other site 1016998013736 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1016998013737 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1016998013738 Walker A motif; other site 1016998013739 ATP binding site [chemical binding]; other site 1016998013740 Walker B motif; other site 1016998013741 arginine finger; other site 1016998013742 Transcriptional antiterminator [Transcription]; Region: COG3933 1016998013743 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1016998013744 active pocket/dimerization site; other site 1016998013745 active site 1016998013746 phosphorylation site [posttranslational modification] 1016998013747 PRD domain; Region: PRD; pfam00874 1016998013748 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1016998013749 active pocket/dimerization site; other site 1016998013750 active site 1016998013751 phosphorylation site [posttranslational modification] 1016998013752 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1016998013753 active site 1016998013754 phosphorylation site [posttranslational modification] 1016998013755 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 1016998013756 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1016998013757 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1016998013758 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1016998013759 dimer interface [polypeptide binding]; other site 1016998013760 active site 1016998013761 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1016998013762 dimer interface [polypeptide binding]; other site 1016998013763 active site 1016998013764 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1016998013765 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1016998013766 putative active site [active] 1016998013767 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1016998013768 phosphoglycerol transferase I; Provisional; Region: PRK03776 1016998013769 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1016998013770 hypothetical protein; Provisional; Region: PRK11667 1016998013771 DNA replication protein DnaC; Validated; Region: PRK07952 1016998013772 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1016998013773 Walker A motif; other site 1016998013774 ATP binding site [chemical binding]; other site 1016998013775 Walker B motif; other site 1016998013776 primosomal protein DnaI; Provisional; Region: PRK02854 1016998013777 hypothetical protein; Provisional; Region: PRK09917 1016998013778 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1016998013779 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1016998013780 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1016998013781 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1016998013782 DNA binding residues [nucleotide binding] 1016998013783 dimerization interface [polypeptide binding]; other site 1016998013784 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 1016998013785 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1016998013786 DNA binding residues [nucleotide binding] 1016998013787 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1016998013788 putative deacylase active site [active] 1016998013789 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 1016998013790 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1016998013791 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1016998013792 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1016998013793 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1016998013794 metal binding site [ion binding]; metal-binding site 1016998013795 active site 1016998013796 I-site; other site 1016998013797 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 1016998013798 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 1016998013799 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 1016998013800 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1016998013801 S-adenosylmethionine binding site [chemical binding]; other site 1016998013802 DNA polymerase III subunit psi; Validated; Region: PRK06856 1016998013803 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1016998013804 Coenzyme A binding pocket [chemical binding]; other site 1016998013805 dUMP phosphatase; Provisional; Region: PRK09449 1016998013806 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1016998013807 motif II; other site 1016998013808 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1016998013809 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1016998013810 G1 box; other site 1016998013811 putative GEF interaction site [polypeptide binding]; other site 1016998013812 GTP/Mg2+ binding site [chemical binding]; other site 1016998013813 Switch I region; other site 1016998013814 G2 box; other site 1016998013815 G3 box; other site 1016998013816 Switch II region; other site 1016998013817 G4 box; other site 1016998013818 G5 box; other site 1016998013819 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1016998013820 periplasmic protein; Provisional; Region: PRK10568 1016998013821 BON domain; Region: BON; pfam04972 1016998013822 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1016998013823 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1016998013824 active site 1016998013825 nucleophile elbow; other site 1016998013826 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1016998013827 active site 1016998013828 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 1016998013829 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1016998013830 FeS/SAM binding site; other site 1016998013831 hypothetical protein; Provisional; Region: PRK10977 1016998013832 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1016998013833 intersubunit interface [polypeptide binding]; other site 1016998013834 active site 1016998013835 catalytic residue [active] 1016998013836 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1016998013837 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1016998013838 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1016998013839 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1016998013840 phosphopentomutase; Provisional; Region: PRK05362 1016998013841 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1016998013842 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1016998013843 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1016998013844 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 1016998013845 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1016998013846 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 1016998013847 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1016998013848 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1016998013849 hypothetical protein; Provisional; Region: PRK11246 1016998013850 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 1016998013851 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1016998013852 motif II; other site 1016998013853 DNA repair protein RadA; Region: sms; TIGR00416 1016998013854 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1016998013855 Walker A motif/ATP binding site; other site 1016998013856 ATP binding site [chemical binding]; other site 1016998013857 Walker B motif; other site 1016998013858 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1016998013859 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1016998013860 non-specific DNA binding site [nucleotide binding]; other site 1016998013861 salt bridge; other site 1016998013862 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 1016998013863 sequence-specific DNA binding site [nucleotide binding]; other site 1016998013864 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 1016998013865 active site 1016998013866 (T/H)XGH motif; other site 1016998013867 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1016998013868 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1016998013869 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1016998013870 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1016998013871 ABC transporter; Region: ABC_tran_2; pfam12848 1016998013872 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1016998013873 lytic murein transglycosylase; Provisional; Region: PRK11619 1016998013874 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1016998013875 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1016998013876 catalytic residue [active] 1016998013877 Trp operon repressor; Provisional; Region: PRK01381 1016998013878 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 1016998013879 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1016998013880 catalytic core [active] 1016998013881 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 1016998013882 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1016998013883 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1016998013884 hypothetical protein; Provisional; Region: PRK10756 1016998013885 CreA protein; Region: CreA; pfam05981 1016998013886 DNA-binding response regulator CreB; Provisional; Region: PRK11083 1016998013887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1016998013888 active site 1016998013889 phosphorylation site [posttranslational modification] 1016998013890 intermolecular recognition site; other site 1016998013891 dimerization interface [polypeptide binding]; other site 1016998013892 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1016998013893 DNA binding site [nucleotide binding] 1016998013894 sensory histidine kinase CreC; Provisional; Region: PRK11100 1016998013895 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1016998013896 dimerization interface [polypeptide binding]; other site 1016998013897 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1016998013898 dimer interface [polypeptide binding]; other site 1016998013899 phosphorylation site [posttranslational modification] 1016998013900 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1016998013901 ATP binding site [chemical binding]; other site 1016998013902 Mg2+ binding site [ion binding]; other site 1016998013903 G-X-G motif; other site 1016998013904 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 1016998013905 putative major fimbrial protein SthE; Provisional; Region: PRK15292 1016998013906 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1016998013907 putative fimbrial protein SthD; Provisional; Region: PRK15293 1016998013908 putative fimbrial outer membrane usher protein SthC; Provisional; Region: PRK15294 1016998013909 PapC N-terminal domain; Region: PapC_N; pfam13954 1016998013910 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1016998013911 PapC C-terminal domain; Region: PapC_C; pfam13953 1016998013912 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 1016998013913 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1016998013914 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1016998013915 putative fimbrial protein SthA; Provisional; Region: PRK15296 1016998013916 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 1016998013917 Helix-turn-helix domain; Region: HTH_36; pfam13730 1016998013918 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1016998013919 two-component response regulator; Provisional; Region: PRK11173 1016998013920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1016998013921 active site 1016998013922 phosphorylation site [posttranslational modification] 1016998013923 intermolecular recognition site; other site 1016998013924 dimerization interface [polypeptide binding]; other site 1016998013925 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1016998013926 DNA binding site [nucleotide binding]