-- dump date 20140620_054338 -- class Genbank::misc_feature -- table misc_feature_note -- id note 476213000001 transcriptional regulator SpvR; Provisional; Region: PRK15243 476213000002 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213000003 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 476213000004 virulence protein SpvA; Provisional; Region: PRK15212 476213000005 virulence protein SpvB; Provisional; Region: PRK15244 476213000006 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 476213000007 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 476213000008 active site 476213000009 conformational flexibility of ligand binding pocket; other site 476213000010 ADP-ribosylating toxin turn-turn motif; other site 476213000011 type III effector phosphothreonine lyase; Provisional; Region: PRK15245 476213000012 virulence protein SpvD; Provisional; Region: PRK15250 476213000013 Transposase IS200 like; Region: Y1_Tnp; pfam01797 476213000014 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 476213000015 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 476213000016 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 476213000017 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 476213000018 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782 476213000019 Protein of unknown function (DUF1401); Region: DUF1401; pfam07180 476213000020 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 476213000021 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 476213000022 active site 476213000023 catalytic residues [active] 476213000024 DNA binding site [nucleotide binding] 476213000025 Int/Topo IB signature motif; other site 476213000026 plasmid maintenance protein CcdB; Provisional; Region: PRK13708 476213000027 plasmid maintenance protein CcdA; Provisional; Region: PRK13710 476213000028 Initiator Replication protein; Region: Rep_3; cl03080 476213000029 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 476213000030 Adhesin biosynthesis transcription regulatory protein; Region: PapB; pfam03333 476213000031 fimbrial protein PefA; Provisional; Region: PRK15214 476213000032 fimbrial outer membrane usher protein PefC; Provisional; Region: PRK15213 476213000033 PapC N-terminal domain; Region: PapC_N; pfam13954 476213000034 Outer membrane usher protein; Region: Usher; pfam00577 476213000035 fimbrial chaperone protein PefD; Provisional; Region: PRK15211 476213000036 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 476213000037 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 476213000038 FaeA-like protein; Region: FaeA; pfam04703 476213000039 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 476213000040 DNA binding residues [nucleotide binding] 476213000041 dimerization interface [polypeptide binding]; other site 476213000042 replication protein; Provisional; Region: PRK13750 476213000043 RepA leader peptide Tap; Provisional; Region: PRK14745 476213000044 replication protein; Provisional; Region: PRK13702 476213000045 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 476213000046 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 476213000047 putative active site [active] 476213000048 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 476213000049 conjugal transfer fertility inhibition protein FinO; Provisional; Region: PRK13754 476213000050 Fertility inhibition protein N terminal; Region: FinO_N; pfam12602 476213000051 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl15270 476213000052 putative kissing complex interaction region; other site 476213000053 putative RNA binding sites [nucleotide binding]; other site 476213000054 conjugal transfer pilus acetylation protein TraX; Provisional; Region: PRK13706 476213000055 conjugal transfer protein TraD; Provisional; Region: PRK13700 476213000056 F sex factor protein N terminal; Region: TraD_N; pfam12615 476213000057 Bacterial conjugation protein TrwB, ATP binding domain. TrwB is a homohexamer encoded by conjugative plasmids in Gram-negative bacteria. TrwB also has an all alpha domain which has been hypothesized to be responsible for DNA binding. TrwB is a component...; Region: TrwB; cd01127 476213000058 multimer interface [polypeptide binding]; other site 476213000059 Walker A motif; other site 476213000060 ATP binding site [chemical binding]; other site 476213000061 Walker B motif; other site 476213000062 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 476213000063 conjugal transfer entry exclusion protein TraS; Provisional; Region: PRK13741 476213000064 conjugal transfer entry exclusion protein TraS; Provisional; Region: PRK13741 476213000065 conjugal transfer mating pair stabilization protein TraG; Provisional; Region: PRK13735 476213000066 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 476213000067 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 476213000068 Catalytic site [active] 476213000069 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 476213000070 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 476213000071 active site 476213000072 DNA binding site [nucleotide binding] 476213000073 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 476213000074 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 476213000075 ParB-like nuclease domain; Region: ParBc; pfam02195 476213000076 ParB family; Region: ParB; pfam08775 476213000077 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 476213000078 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 476213000079 P-loop; other site 476213000080 Magnesium ion binding site [ion binding]; other site 476213000081 Uncharacterized conserved protein [Function unknown]; Region: COG5464 476213000082 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 476213000083 Protein of unknown function (DUF2913); Region: DUF2913; pfam11140 476213000084 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 476213000085 catalytic site [active] 476213000086 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 476213000087 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 476213000088 active site clefts [active] 476213000089 zinc binding site [ion binding]; other site 476213000090 dimer interface [polypeptide binding]; other site 476213000091 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 476213000092 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 476213000093 catalytic residues [active] 476213000094 catalytic nucleophile [active] 476213000095 Presynaptic Site I dimer interface [polypeptide binding]; other site 476213000096 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 476213000097 Synaptic Flat tetramer interface [polypeptide binding]; other site 476213000098 Synaptic Site I dimer interface [polypeptide binding]; other site 476213000099 DNA binding site [nucleotide binding] 476213000100 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 476213000101 DNA-binding interface [nucleotide binding]; DNA binding site 476213000102 Integrase core domain; Region: rve; pfam00665 476213000103 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 476213000104 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 476213000105 Walker A motif; other site 476213000106 ATP binding site [chemical binding]; other site 476213000107 Walker B motif; other site 476213000108 Homeodomain-like domain; Region: HTH_23; pfam13384 476213000109 Winged helix-turn helix; Region: HTH_29; pfam13551 476213000110 Homeodomain-like domain; Region: HTH_32; pfam13565 476213000111 DDE superfamily endonuclease; Region: DDE_3; pfam13358 476213000112 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 476213000113 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 476213000114 putative catalytic residues [active] 476213000115 putative nucleotide binding site [chemical binding]; other site 476213000116 putative aspartate binding site [chemical binding]; other site 476213000117 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 476213000118 dimer interface [polypeptide binding]; other site 476213000119 putative threonine allosteric regulatory site; other site 476213000120 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 476213000121 putative threonine allosteric regulatory site; other site 476213000122 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 476213000123 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 476213000124 homoserine kinase; Provisional; Region: PRK01212 476213000125 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 476213000126 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 476213000127 threonine synthase; Validated; Region: PRK09225 476213000128 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 476213000129 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 476213000130 catalytic residue [active] 476213000131 hypothetical protein; Validated; Region: PRK02101 476213000132 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 476213000133 transaldolase-like protein; Provisional; Region: PTZ00411 476213000134 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 476213000135 active site 476213000136 dimer interface [polypeptide binding]; other site 476213000137 catalytic residue [active] 476213000138 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 476213000139 MPT binding site; other site 476213000140 trimer interface [polypeptide binding]; other site 476213000141 hypothetical protein; Provisional; Region: PRK10659 476213000142 hypothetical protein; Provisional; Region: PRK10236 476213000143 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 476213000144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 476213000145 Protein of unknown function (DUF2541); Region: DUF2541; cl08090 476213000146 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 476213000147 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 476213000148 nucleotide binding site [chemical binding]; other site 476213000149 NEF interaction site [polypeptide binding]; other site 476213000150 SBD interface [polypeptide binding]; other site 476213000151 chaperone protein DnaJ; Provisional; Region: PRK10767 476213000152 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 476213000153 HSP70 interaction site [polypeptide binding]; other site 476213000154 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 476213000155 substrate binding site [polypeptide binding]; other site 476213000156 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 476213000157 Zn binding sites [ion binding]; other site 476213000158 dimer interface [polypeptide binding]; other site 476213000159 Transcriptional regulator [Transcription]; Region: LysR; COG0583 476213000160 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213000161 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 476213000162 dimerization interface [polypeptide binding]; other site 476213000163 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 476213000164 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 476213000165 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 476213000166 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 476213000167 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 476213000168 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 476213000169 active site 476213000170 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 476213000171 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 476213000172 aromatic chitin/cellulose binding site residues [chemical binding]; other site 476213000173 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 476213000174 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 476213000175 fimbrial protein BcfA; Provisional; Region: PRK15187 476213000176 fimbrial chaperone protein BcfB; Provisional; Region: PRK15188 476213000177 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 476213000178 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 476213000179 fimbrial protein BcfD; Provisional; Region: PRK15189 476213000180 fimbrial protein BcfE; Provisional; Region: PRK15190 476213000181 fimbrial protein BcfF; Provisional; Region: PRK15191 476213000182 fimbrial chaperone BcfG; Provisional; Region: PRK15192 476213000183 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 476213000184 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 476213000185 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 476213000186 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 476213000187 catalytic residues [active] 476213000188 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 476213000189 Arylsulfotransferase (ASST); Region: Arylsulfotrans; cl19972 476213000190 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 476213000191 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 476213000192 Sulfatase; Region: Sulfatase; pfam00884 476213000193 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 476213000194 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 476213000195 FeS/SAM binding site; other site 476213000196 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 476213000197 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 476213000198 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 476213000199 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213000200 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 476213000201 putative dimerization interface [polypeptide binding]; other site 476213000202 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 476213000203 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 476213000204 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 476213000205 putative active site [active] 476213000206 putative catalytic site [active] 476213000207 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 476213000208 putative symporter YagG; Provisional; Region: PRK09669; cl15392 476213000209 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 476213000210 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 476213000211 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 476213000212 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 476213000213 active site 476213000214 Riboflavin kinase; Region: Flavokinase; smart00904 476213000215 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 476213000216 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 476213000217 active site 476213000218 HIGH motif; other site 476213000219 KMSKS motif; other site 476213000220 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 476213000221 tRNA binding surface [nucleotide binding]; other site 476213000222 anticodon binding site; other site 476213000223 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 476213000224 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 476213000225 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 476213000226 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 476213000227 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 476213000228 Fe-S cluster binding site [ion binding]; other site 476213000229 substrate binding site [chemical binding]; other site 476213000230 catalytic site [active] 476213000231 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 476213000232 active site 476213000233 tetramer interface [polypeptide binding]; other site 476213000234 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 476213000235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 476213000236 active site 476213000237 phosphorylation site [posttranslational modification] 476213000238 intermolecular recognition site; other site 476213000239 dimerization interface [polypeptide binding]; other site 476213000240 Transcriptional regulator; Region: CitT; pfam12431 476213000241 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 476213000242 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 476213000243 PAS domain; Region: PAS; smart00091 476213000244 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 476213000245 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 476213000246 ATP binding site [chemical binding]; other site 476213000247 Mg2+ binding site [ion binding]; other site 476213000248 G-X-G motif; other site 476213000249 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15477 476213000250 oxaloacetate decarboxylase; Provisional; Region: PRK14040 476213000251 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 476213000252 active site 476213000253 catalytic residues [active] 476213000254 metal binding site [ion binding]; metal-binding site 476213000255 homodimer binding site [polypeptide binding]; other site 476213000256 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 476213000257 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 476213000258 carboxyltransferase (CT) interaction site; other site 476213000259 biotinylation site [posttranslational modification]; other site 476213000260 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 476213000261 Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493 476213000262 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 476213000263 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 476213000264 putative active site [active] 476213000265 (T/H)XGH motif; other site 476213000266 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 476213000267 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 476213000268 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 476213000269 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 476213000270 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 476213000271 triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125 476213000272 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 476213000273 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 476213000274 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 476213000275 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 476213000276 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 476213000277 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 476213000278 catalytic site [active] 476213000279 subunit interface [polypeptide binding]; other site 476213000280 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 476213000281 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 476213000282 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 476213000283 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 476213000284 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 476213000285 ATP-grasp domain; Region: ATP-grasp_4; cl17255 476213000286 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 476213000287 IMP binding site; other site 476213000288 dimer interface [polypeptide binding]; other site 476213000289 interdomain contacts; other site 476213000290 partial ornithine binding site; other site 476213000291 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 476213000292 carnitine operon protein CaiE; Provisional; Region: PRK13627 476213000293 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 476213000294 putative trimer interface [polypeptide binding]; other site 476213000295 putative metal binding site [ion binding]; other site 476213000296 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 476213000297 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 476213000298 substrate binding site [chemical binding]; other site 476213000299 oxyanion hole (OAH) forming residues; other site 476213000300 trimer interface [polypeptide binding]; other site 476213000301 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 476213000302 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 476213000303 acyl-activating enzyme (AAE) consensus motif; other site 476213000304 putative AMP binding site [chemical binding]; other site 476213000305 putative active site [active] 476213000306 putative CoA binding site [chemical binding]; other site 476213000307 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 476213000308 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 476213000309 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 476213000310 active site 476213000311 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 476213000312 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 476213000313 Ligand binding site [chemical binding]; other site 476213000314 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 476213000315 Electron transfer flavoprotein domain; Region: ETF; pfam01012 476213000316 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 476213000317 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 476213000318 putative oxidoreductase FixC; Provisional; Region: PRK10157 476213000319 ferredoxin-like protein FixX; Provisional; Region: PRK15449 476213000320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213000321 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 476213000322 putative substrate translocation pore; other site 476213000323 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 476213000324 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 476213000325 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 476213000326 Sulfatase; Region: Sulfatase; cl19157 476213000327 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 476213000328 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 476213000329 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 476213000330 TrkA-N domain; Region: TrkA_N; pfam02254 476213000331 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 476213000332 folate binding site [chemical binding]; other site 476213000333 NADP+ binding site [chemical binding]; other site 476213000334 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 476213000335 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 476213000336 active site 476213000337 metal binding site [ion binding]; metal-binding site 476213000338 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 476213000339 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 476213000340 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 476213000341 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 476213000342 SurA N-terminal domain; Region: SurA_N; pfam09312 476213000343 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 476213000344 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 476213000345 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 476213000346 OstA-like protein; Region: OstA; pfam03968 476213000347 Organic solvent tolerance protein; Region: OstA_C; pfam04453 476213000348 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 476213000349 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 476213000350 putative metal binding site [ion binding]; other site 476213000351 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 476213000352 HSP70 interaction site [polypeptide binding]; other site 476213000353 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 476213000354 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 476213000355 active site 476213000356 ATP-dependent helicase HepA; Validated; Region: PRK04914 476213000357 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 476213000358 ATP binding site [chemical binding]; other site 476213000359 putative Mg++ binding site [ion binding]; other site 476213000360 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 476213000361 nucleotide binding region [chemical binding]; other site 476213000362 ATP-binding site [chemical binding]; other site 476213000363 RNA polymerase recycling family C-terminal; Region: RapA_C; pfam12137 476213000364 DNA polymerase II; Reviewed; Region: PRK05762 476213000365 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 476213000366 active site 476213000367 catalytic site [active] 476213000368 substrate binding site [chemical binding]; other site 476213000369 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 476213000370 active site 476213000371 metal-binding site 476213000372 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 476213000373 putative active site [active] 476213000374 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 476213000375 intersubunit interface [polypeptide binding]; other site 476213000376 active site 476213000377 Zn2+ binding site [ion binding]; other site 476213000378 ribulokinase; Provisional; Region: PRK04123 476213000379 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 476213000380 N- and C-terminal domain interface [polypeptide binding]; other site 476213000381 active site 476213000382 MgATP binding site [chemical binding]; other site 476213000383 carbohydrate binding site [chemical binding]; other site 476213000384 homodimer interface [polypeptide binding]; other site 476213000385 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 476213000386 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 476213000387 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213000388 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213000389 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 476213000390 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 476213000391 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 476213000392 Walker A/P-loop; other site 476213000393 ATP binding site [chemical binding]; other site 476213000394 Q-loop/lid; other site 476213000395 ABC transporter signature motif; other site 476213000396 Walker B; other site 476213000397 D-loop; other site 476213000398 H-loop/switch region; other site 476213000399 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 476213000400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213000401 dimer interface [polypeptide binding]; other site 476213000402 conserved gate region; other site 476213000403 putative PBP binding loops; other site 476213000404 ABC-ATPase subunit interface; other site 476213000405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213000406 dimer interface [polypeptide binding]; other site 476213000407 conserved gate region; other site 476213000408 putative PBP binding loops; other site 476213000409 ABC-ATPase subunit interface; other site 476213000410 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 476213000411 transcriptional regulator SgrR; Provisional; Region: PRK13626 476213000412 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 476213000413 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 476213000414 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 476213000415 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 476213000416 substrate binding site [chemical binding]; other site 476213000417 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 476213000418 substrate binding site [chemical binding]; other site 476213000419 ligand binding site [chemical binding]; other site 476213000420 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 476213000421 2-isopropylmalate synthase; Validated; Region: PRK00915 476213000422 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 476213000423 active site 476213000424 catalytic residues [active] 476213000425 metal binding site [ion binding]; metal-binding site 476213000426 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 476213000427 leu operon leader peptide; Provisional; Region: PRK14744 476213000428 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 476213000429 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213000430 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 476213000431 putative substrate binding pocket [chemical binding]; other site 476213000432 putative dimerization interface [polypeptide binding]; other site 476213000433 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 476213000434 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 476213000435 PYR/PP interface [polypeptide binding]; other site 476213000436 dimer interface [polypeptide binding]; other site 476213000437 TPP binding site [chemical binding]; other site 476213000438 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 476213000439 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 476213000440 TPP-binding site [chemical binding]; other site 476213000441 dimer interface [polypeptide binding]; other site 476213000442 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 476213000443 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 476213000444 putative valine binding site [chemical binding]; other site 476213000445 dimer interface [polypeptide binding]; other site 476213000446 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 476213000447 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 476213000448 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 476213000449 DNA binding site [nucleotide binding] 476213000450 domain linker motif; other site 476213000451 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 476213000452 dimerization interface [polypeptide binding]; other site 476213000453 ligand binding site [chemical binding]; other site 476213000454 mraZ protein; Region: TIGR00242 476213000455 MraZ protein; Region: MraZ; pfam02381 476213000456 MraZ protein; Region: MraZ; pfam02381 476213000457 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 476213000458 cell division protein FtsL; Provisional; Region: PRK10772 476213000459 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 476213000460 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 476213000461 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 476213000462 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 476213000463 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 476213000464 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 476213000465 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 476213000466 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 476213000467 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 476213000468 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 476213000469 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 476213000470 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 476213000471 Mg++ binding site [ion binding]; other site 476213000472 putative catalytic motif [active] 476213000473 putative substrate binding site [chemical binding]; other site 476213000474 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 476213000475 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 476213000476 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 476213000477 cell division protein FtsW; Provisional; Region: PRK10774 476213000478 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 476213000479 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 476213000480 active site 476213000481 homodimer interface [polypeptide binding]; other site 476213000482 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 476213000483 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 476213000484 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 476213000485 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 476213000486 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 476213000487 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 476213000488 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 476213000489 cell division protein FtsQ; Provisional; Region: PRK10775 476213000490 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 476213000491 Cell division protein FtsQ; Region: FtsQ; pfam03799 476213000492 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 476213000493 Cell division protein FtsA; Region: FtsA; pfam14450 476213000494 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 476213000495 Cell division protein FtsA; Region: FtsA; pfam14450 476213000496 cell division protein FtsZ; Validated; Region: PRK09330 476213000497 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 476213000498 nucleotide binding site [chemical binding]; other site 476213000499 SulA interaction site; other site 476213000500 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 476213000501 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 476213000502 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 476213000503 SecA regulator SecM; Provisional; Region: PRK02943 476213000504 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 476213000505 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 476213000506 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 476213000507 SEC-C motif; Region: SEC-C; pfam02810 476213000508 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 476213000509 active site 476213000510 8-oxo-dGMP binding site [chemical binding]; other site 476213000511 nudix motif; other site 476213000512 metal binding site [ion binding]; metal-binding site 476213000513 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 476213000514 active site 476213000515 catalytic tetrad [active] 476213000516 Transcriptional regulator [Transcription]; Region: LysR; COG0583 476213000517 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213000518 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 476213000519 putative effector binding pocket; other site 476213000520 putative dimerization interface [polypeptide binding]; other site 476213000521 DNA gyrase inhibitor; Reviewed; Region: PRK00418 476213000522 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 476213000523 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 476213000524 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 476213000525 CoA-binding site [chemical binding]; other site 476213000526 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 476213000527 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 476213000528 active site 476213000529 type IV pilin biogenesis protein; Provisional; Region: PRK10573 476213000530 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 476213000531 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 476213000532 hypothetical protein; Provisional; Region: PRK10436 476213000533 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 476213000534 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 476213000535 Walker A motif; other site 476213000536 ATP binding site [chemical binding]; other site 476213000537 Walker B motif; other site 476213000538 putative major pilin subunit; Provisional; Region: PRK10574 476213000539 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 476213000540 Pilin (bacterial filament); Region: Pilin; pfam00114 476213000541 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 476213000542 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 476213000543 dimerization interface [polypeptide binding]; other site 476213000544 active site 476213000545 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 476213000546 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 476213000547 amidase catalytic site [active] 476213000548 Zn binding residues [ion binding]; other site 476213000549 substrate binding site [chemical binding]; other site 476213000550 regulatory protein AmpE; Provisional; Region: PRK10987 476213000551 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 476213000552 active site 476213000553 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 476213000554 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213000555 putative substrate translocation pore; other site 476213000556 amino acid transporter; Region: 2A0306; TIGR00909 476213000557 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 476213000558 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 476213000559 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 476213000560 DNA-binding site [nucleotide binding]; DNA binding site 476213000561 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 476213000562 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 476213000563 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 476213000564 dimer interface [polypeptide binding]; other site 476213000565 TPP-binding site [chemical binding]; other site 476213000566 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 476213000567 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 476213000568 E3 interaction surface; other site 476213000569 lipoyl attachment site [posttranslational modification]; other site 476213000570 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 476213000571 E3 interaction surface; other site 476213000572 lipoyl attachment site [posttranslational modification]; other site 476213000573 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 476213000574 E3 interaction surface; other site 476213000575 lipoyl attachment site [posttranslational modification]; other site 476213000576 e3 binding domain; Region: E3_binding; pfam02817 476213000577 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 476213000578 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 476213000579 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 476213000580 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 476213000581 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 476213000582 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 476213000583 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 476213000584 Aconitate B N-terminal domain; Region: Aconitase_B_N; pfam11791 476213000585 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 476213000586 substrate binding site [chemical binding]; other site 476213000587 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 476213000588 substrate binding site [chemical binding]; other site 476213000589 ligand binding site [chemical binding]; other site 476213000590 putative inner membrane protein; Provisional; Region: PRK09823 476213000591 Low molecular weight phosphatase family; Region: LMWPc; cl00105 476213000592 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3112 476213000593 2-keto-3-deoxygluconate permease; Provisional; Region: PRK12460 476213000594 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 476213000595 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 476213000596 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 476213000597 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 476213000598 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 476213000599 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 476213000600 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 476213000601 S-adenosylmethionine binding site [chemical binding]; other site 476213000602 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 476213000603 multicopper oxidase; Provisional; Region: PRK10965 476213000604 Cupredoxin superfamily; Region: Cupredoxin; cl19115 476213000605 The second Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_2_CueO_FtsP; cd13867 476213000606 Domain 1 interface [polypeptide binding]; other site 476213000607 Domain 3 interface [polypeptide binding]; other site 476213000608 The third Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_3_CueO_FtsP; cd13890 476213000609 Domain 2 interface [polypeptide binding]; other site 476213000610 Domain 1 interface [polypeptide binding]; other site 476213000611 Type 1 (T1) Cu binding site [ion binding]; other site 476213000612 trinuclear Cu binding site [ion binding]; other site 476213000613 Glucose dehydrogenase [Carbohydrate transport and metabolism]; Region: Gcd; COG4993 476213000614 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 476213000615 Trp docking motif [polypeptide binding]; other site 476213000616 putative active site [active] 476213000617 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 476213000618 active site 476213000619 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 476213000620 active site clefts [active] 476213000621 zinc binding site [ion binding]; other site 476213000622 dimer interface [polypeptide binding]; other site 476213000623 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 476213000624 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 476213000625 Walker A/P-loop; other site 476213000626 ATP binding site [chemical binding]; other site 476213000627 Q-loop/lid; other site 476213000628 ABC transporter signature motif; other site 476213000629 Walker B; other site 476213000630 D-loop; other site 476213000631 H-loop/switch region; other site 476213000632 inner membrane transport permease; Provisional; Region: PRK15066 476213000633 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 476213000634 putative fimbrial protein StiH; Provisional; Region: PRK15297 476213000635 fimbrial outer membrane usher protein StiC; Provisional; Region: PRK15298 476213000636 PapC N-terminal domain; Region: PapC_N; pfam13954 476213000637 Outer membrane usher protein; Region: Usher; pfam00577 476213000638 PapC C-terminal domain; Region: PapC_C; pfam13953 476213000639 fimbrial chaperone protein StiB; Provisional; Region: PRK15299 476213000640 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 476213000641 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 476213000642 fimbrial protein StiA; Provisional; Region: PRK15300 476213000643 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 476213000644 active pocket/dimerization site; other site 476213000645 active site 476213000646 phosphorylation site [posttranslational modification] 476213000647 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 476213000648 putative active site [active] 476213000649 putative metal binding site [ion binding]; other site 476213000650 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 476213000651 tetramerization interface [polypeptide binding]; other site 476213000652 active site 476213000653 Pantoate-beta-alanine ligase; Region: PanC; cd00560 476213000654 active site 476213000655 ATP-binding site [chemical binding]; other site 476213000656 pantoate-binding site; other site 476213000657 HXXH motif; other site 476213000658 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 476213000659 oligomerization interface [polypeptide binding]; other site 476213000660 active site 476213000661 metal binding site [ion binding]; metal-binding site 476213000662 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 476213000663 catalytic center binding site [active] 476213000664 ATP binding site [chemical binding]; other site 476213000665 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 476213000666 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 476213000667 active site 476213000668 NTP binding site [chemical binding]; other site 476213000669 metal binding triad [ion binding]; metal-binding site 476213000670 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 476213000671 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 476213000672 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 476213000673 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 476213000674 active site 476213000675 nucleotide binding site [chemical binding]; other site 476213000676 HIGH motif; other site 476213000677 KMSKS motif; other site 476213000678 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 476213000679 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 476213000680 2'-5' RNA ligase; Provisional; Region: PRK15124 476213000681 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 476213000682 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 476213000683 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 476213000684 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 476213000685 ATP binding site [chemical binding]; other site 476213000686 putative Mg++ binding site [ion binding]; other site 476213000687 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 476213000688 nucleotide binding region [chemical binding]; other site 476213000689 ATP-binding site [chemical binding]; other site 476213000690 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 476213000691 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 476213000692 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 476213000693 Transmembrane domain of transglycosylase PBP1 at N-terminal; Region: PBP1_TM; pfam14812 476213000694 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 476213000695 Transglycosylase; Region: Transgly; pfam00912 476213000696 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 476213000697 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 476213000698 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 476213000699 N-terminal plug; other site 476213000700 ligand-binding site [chemical binding]; other site 476213000701 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 476213000702 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 476213000703 Walker A/P-loop; other site 476213000704 ATP binding site [chemical binding]; other site 476213000705 Q-loop/lid; other site 476213000706 ABC transporter signature motif; other site 476213000707 Walker B; other site 476213000708 D-loop; other site 476213000709 H-loop/switch region; other site 476213000710 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 476213000711 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 476213000712 siderophore binding site; other site 476213000713 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 476213000714 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 476213000715 ABC-ATPase subunit interface; other site 476213000716 dimer interface [polypeptide binding]; other site 476213000717 putative PBP binding regions; other site 476213000718 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 476213000719 ABC-ATPase subunit interface; other site 476213000720 dimer interface [polypeptide binding]; other site 476213000721 putative PBP binding regions; other site 476213000722 putative fimbrial subunit StfA; Provisional; Region: PRK15283 476213000723 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 476213000724 PapC N-terminal domain; Region: PapC_N; pfam13954 476213000725 Outer membrane usher protein; Region: Usher; pfam00577 476213000726 PapC C-terminal domain; Region: PapC_C; pfam13953 476213000727 putative minor fimbrial subunit StfE; Provisional; Region: PRK15286 476213000728 putative minor fimbrial subunit StfF; Provisional; Region: PRK15287 476213000729 putative minor fimbrial subunit StfG; Provisional; Region: PRK15288 476213000730 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 476213000731 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 476213000732 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 476213000733 inhibitor-cofactor binding pocket; inhibition site 476213000734 pyridoxal 5'-phosphate binding site [chemical binding]; other site 476213000735 catalytic residue [active] 476213000736 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 476213000737 Cl- selectivity filter; other site 476213000738 Cl- binding residues [ion binding]; other site 476213000739 pore gating glutamate residue; other site 476213000740 dimer interface [polypeptide binding]; other site 476213000741 H+/Cl- coupling transport residue; other site 476213000742 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 476213000743 hypothetical protein; Provisional; Region: PRK10578 476213000744 UPF0126 domain; Region: UPF0126; pfam03458 476213000745 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 476213000746 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 476213000747 cobalamin binding residues [chemical binding]; other site 476213000748 putative BtuC binding residues; other site 476213000749 dimer interface [polypeptide binding]; other site 476213000750 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 476213000751 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 476213000752 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 476213000753 Zn2+ binding site [ion binding]; other site 476213000754 Mg2+ binding site [ion binding]; other site 476213000755 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 476213000756 serine endoprotease; Provisional; Region: PRK10942 476213000757 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 476213000758 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 476213000759 protein binding site [polypeptide binding]; other site 476213000760 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 476213000761 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 476213000762 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 476213000763 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 476213000764 hypothetical protein; Provisional; Region: PRK13677 476213000765 shikimate transporter; Provisional; Region: PRK09952 476213000766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213000767 putative substrate translocation pore; other site 476213000768 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 476213000769 Tetrahydrodipicolinate N-succinyltransferase N-terminal; Region: THDPS_N_2; pfam14805 476213000770 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 476213000771 trimer interface [polypeptide binding]; other site 476213000772 active site 476213000773 substrate binding site [chemical binding]; other site 476213000774 CoA binding site [chemical binding]; other site 476213000775 PII uridylyl-transferase; Provisional; Region: PRK05007 476213000776 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 476213000777 metal binding triad; other site 476213000778 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 476213000779 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 476213000780 Zn2+ binding site [ion binding]; other site 476213000781 Mg2+ binding site [ion binding]; other site 476213000782 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 476213000783 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 476213000784 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 476213000785 active site 476213000786 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 476213000787 rRNA interaction site [nucleotide binding]; other site 476213000788 S8 interaction site; other site 476213000789 putative laminin-1 binding site; other site 476213000790 elongation factor Ts; Provisional; Region: tsf; PRK09377 476213000791 UBA/TS-N domain; Region: UBA; pfam00627 476213000792 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 476213000793 putative nucleotide binding site [chemical binding]; other site 476213000794 uridine monophosphate binding site [chemical binding]; other site 476213000795 homohexameric interface [polypeptide binding]; other site 476213000796 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 476213000797 hinge region; other site 476213000798 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 476213000799 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 476213000800 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 476213000801 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 476213000802 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 476213000803 active site 476213000804 dimer interface [polypeptide binding]; other site 476213000805 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 476213000806 zinc metallopeptidase RseP; Provisional; Region: PRK10779 476213000807 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 476213000808 active site 476213000809 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 476213000810 protein binding site [polypeptide binding]; other site 476213000811 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 476213000812 protein binding site [polypeptide binding]; other site 476213000813 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 476213000814 putative substrate binding region [chemical binding]; other site 476213000815 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 476213000816 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 476213000817 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 476213000818 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 476213000819 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 476213000820 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 476213000821 Surface antigen; Region: Bac_surface_Ag; pfam01103 476213000822 periplasmic chaperone; Provisional; Region: PRK10780 476213000823 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 476213000824 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 476213000825 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 476213000826 trimer interface [polypeptide binding]; other site 476213000827 active site 476213000828 UDP-GlcNAc binding site [chemical binding]; other site 476213000829 lipid binding site [chemical binding]; lipid-binding site 476213000830 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 476213000831 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 476213000832 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 476213000833 active site 476213000834 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 476213000835 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 476213000836 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 476213000837 RNA/DNA hybrid binding site [nucleotide binding]; other site 476213000838 active site 476213000839 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 476213000840 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 476213000841 putative active site [active] 476213000842 putative PHP Thumb interface [polypeptide binding]; other site 476213000843 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 476213000844 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 476213000845 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 476213000846 generic binding surface II; other site 476213000847 generic binding surface I; other site 476213000848 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 476213000849 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 476213000850 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 476213000851 putative sugar binding site [chemical binding]; other site 476213000852 catalytic residues [active] 476213000853 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 476213000854 lysine decarboxylase LdcC; Provisional; Region: PRK15399 476213000855 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 476213000856 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 476213000857 homodimer interface [polypeptide binding]; other site 476213000858 pyridoxal 5'-phosphate binding site [chemical binding]; other site 476213000859 catalytic residue [active] 476213000860 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 476213000861 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 476213000862 putative metal binding site [ion binding]; other site 476213000863 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 476213000864 hypothetical protein; Provisional; Region: PRK04964 476213000865 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 476213000866 hypothetical protein; Provisional; Region: PRK09256 476213000867 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 476213000868 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 476213000869 NlpE N-terminal domain; Region: NlpE; cl19736 476213000870 prolyl-tRNA synthetase; Provisional; Region: PRK09194 476213000871 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 476213000872 dimer interface [polypeptide binding]; other site 476213000873 motif 1; other site 476213000874 active site 476213000875 motif 2; other site 476213000876 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 476213000877 putative deacylase active site [active] 476213000878 motif 3; other site 476213000879 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 476213000880 anticodon binding site; other site 476213000881 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 476213000882 homodimer interaction site [polypeptide binding]; other site 476213000883 cofactor binding site; other site 476213000884 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 476213000885 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 476213000886 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213000887 dimer interface [polypeptide binding]; other site 476213000888 conserved gate region; other site 476213000889 putative PBP binding loops; other site 476213000890 ABC-ATPase subunit interface; other site 476213000891 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 476213000892 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 476213000893 Walker A/P-loop; other site 476213000894 ATP binding site [chemical binding]; other site 476213000895 Q-loop/lid; other site 476213000896 ABC transporter signature motif; other site 476213000897 Walker B; other site 476213000898 D-loop; other site 476213000899 H-loop/switch region; other site 476213000900 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 476213000901 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 476213000902 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 476213000903 active site 476213000904 motif I; other site 476213000905 motif II; other site 476213000906 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 476213000907 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 476213000908 active site 476213000909 catalytic tetrad [active] 476213000910 Transcriptional regulator [Transcription]; Region: LysR; COG0583 476213000911 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213000912 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 476213000913 putative effector binding pocket; other site 476213000914 dimerization interface [polypeptide binding]; other site 476213000915 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 476213000916 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213000917 putative substrate translocation pore; other site 476213000918 hypothetical protein; Provisional; Region: PRK05421 476213000919 putative catalytic site [active] 476213000920 putative metal binding site [ion binding]; other site 476213000921 putative phosphate binding site [ion binding]; other site 476213000922 putative catalytic site [active] 476213000923 putative phosphate binding site [ion binding]; other site 476213000924 putative metal binding site [ion binding]; other site 476213000925 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 476213000926 S-adenosylmethionine binding site [chemical binding]; other site 476213000927 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 476213000928 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 476213000929 N-acetyl-D-glucosamine binding site [chemical binding]; other site 476213000930 catalytic residue [active] 476213000931 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 476213000932 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 476213000933 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 476213000934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 476213000935 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 476213000936 RNA/DNA hybrid binding site [nucleotide binding]; other site 476213000937 active site 476213000938 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 476213000939 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 476213000940 active site 476213000941 catalytic site [active] 476213000942 substrate binding site [chemical binding]; other site 476213000943 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 476213000944 ImpA-related N-terminal; Region: ImpA-rel_N; cl19907 476213000945 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 476213000946 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 476213000947 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 476213000948 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 476213000949 ImpE protein; Region: ImpE; pfam07024 476213000950 Phage terminase large subunit (GpA); Region: Terminase_GpA; cl19377 476213000951 similar to hypothetical protein 476213000952 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 476213000953 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 476213000954 Walker A motif; other site 476213000955 ATP binding site [chemical binding]; other site 476213000956 Walker B motif; other site 476213000957 arginine finger; other site 476213000958 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 476213000959 Walker A motif; other site 476213000960 ATP binding site [chemical binding]; other site 476213000961 Walker B motif; other site 476213000962 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 476213000963 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 476213000964 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 476213000965 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 476213000966 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 476213000967 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 476213000968 hypothetical protein; Provisional; Region: PRK08126 476213000969 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 476213000970 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 476213000971 ligand binding site [chemical binding]; other site 476213000972 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 476213000973 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 476213000974 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 476213000975 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 476213000976 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 476213000977 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4893 476213000978 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 476213000979 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 476213000980 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 476213000981 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 476213000982 PAAR motif; Region: PAAR_motif; pfam05488 476213000983 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 476213000984 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 476213000985 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 476213000986 RHS Repeat; Region: RHS_repeat; pfam05593 476213000987 RHS Repeat; Region: RHS_repeat; pfam05593 476213000988 RHS Repeat; Region: RHS_repeat; pfam05593 476213000989 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 476213000990 RHS Repeat; Region: RHS_repeat; pfam05593 476213000991 RHS Repeat; Region: RHS_repeat; pfam05593 476213000992 RHS Repeat; Region: RHS_repeat; pfam05593 476213000993 RHS Repeat; Region: RHS_repeat; pfam05593 476213000994 RHS Repeat; Region: RHS_repeat; pfam05593 476213000995 RHS Repeat; Region: RHS_repeat; pfam05593 476213000996 RHS Repeat; Region: RHS_repeat; pfam05593 476213000997 RHS protein; Region: RHS; pfam03527 476213000998 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 476213000999 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 476213001000 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 476213001001 Protein of unknown function (DUF4019); Region: DUF4019; pfam13211 476213001002 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 476213001003 Transposase; Region: HTH_Tnp_1; cl17663 476213001004 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 476213001005 Integrase core domain; Region: rve_3; pfam13683 476213001006 Saf-pilin pilus formation protein SafA; Provisional; Region: PRK15221 476213001007 pili assembly chaperone protein SafB; Provisional; Region: PRK15224 476213001008 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 476213001009 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 476213001010 putative pilin structural protein SafD; Provisional; Region: PRK15222 476213001011 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 476213001012 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 476213001013 putative active site [active] 476213001014 putative metal binding site [ion binding]; other site 476213001015 Transcriptional regulator [Transcription]; Region: LysR; COG0583 476213001016 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213001017 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 476213001018 dimerization interface [polypeptide binding]; other site 476213001019 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 476213001020 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 476213001021 dimer interface [polypeptide binding]; other site 476213001022 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 476213001023 putative active site [active] 476213001024 catalytic triad [active] 476213001025 dimer interface [polypeptide binding]; other site 476213001026 multimer interface [polypeptide binding]; other site 476213001027 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 476213001028 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 476213001029 active site 476213001030 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 476213001031 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 476213001032 dimer interface [polypeptide binding]; other site 476213001033 active site 476213001034 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 476213001035 putative active site [active] 476213001036 Glutamine amidotransferases class-II; Region: GATase_2; pfam00310 476213001037 putative dimer interface [polypeptide binding]; other site 476213001038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 476213001039 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 476213001040 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 476213001041 active site 476213001042 DNA polymerase IV; Validated; Region: PRK02406 476213001043 DNA binding site [nucleotide binding] 476213001044 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 476213001045 tRNA-splicing ligase RtcB; Region: RtcB; pfam01139 476213001046 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 476213001047 putative peptide chain release factor H; Region: release_prfH; TIGR03072 476213001048 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 476213001049 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 476213001050 metal binding site [ion binding]; metal-binding site 476213001051 dimer interface [polypeptide binding]; other site 476213001052 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 476213001053 active site 476213001054 Putative lysophospholipase; Region: Hydrolase_4; cl19140 476213001055 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 476213001056 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 476213001057 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 476213001058 trimer interface [polypeptide binding]; other site 476213001059 eyelet of channel; other site 476213001060 gamma-glutamyl kinase; Provisional; Region: PRK05429 476213001061 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 476213001062 nucleotide binding site [chemical binding]; other site 476213001063 homotetrameric interface [polypeptide binding]; other site 476213001064 putative phosphate binding site [ion binding]; other site 476213001065 putative allosteric binding site; other site 476213001066 PUA domain; Region: PUA; pfam01472 476213001067 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 476213001068 putative catalytic cysteine [active] 476213001069 Integrase core domain; Region: rve; pfam00665 476213001070 Integrase core domain; Region: rve_2; pfam13333 476213001071 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 476213001072 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 476213001073 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213001074 putative substrate translocation pore; other site 476213001075 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 476213001076 substrate binding site [chemical binding]; other site 476213001077 ligand binding site [chemical binding]; other site 476213001078 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 476213001079 substrate binding site [chemical binding]; other site 476213001080 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 476213001081 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 476213001082 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 476213001083 Putative lysophospholipase; Region: Hydrolase_4; cl19140 476213001084 transcriptional activator TtdR; Provisional; Region: PRK09801 476213001085 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213001086 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 476213001087 putative effector binding pocket; other site 476213001088 putative dimerization interface [polypeptide binding]; other site 476213001089 YjzC-like protein; Region: YjzC; pfam14168 476213001090 fimbrial assembly chaperone StbE; Provisional; Region: PRK15246 476213001091 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 476213001092 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 476213001093 putative fimbrial usher protein StbD; Provisional; Region: PRK15247 476213001094 fimbrial outer membrane usher protein StbC; Provisional; Region: PRK15248 476213001095 PapC N-terminal domain; Region: PapC_N; pfam13954 476213001096 Outer membrane usher protein; Region: Usher; pfam00577 476213001097 PapC C-terminal domain; Region: PapC_C; pfam13953 476213001098 fimbrial chaperone protein StbB; Provisional; Region: PRK15249 476213001099 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 476213001100 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 476213001101 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 476213001102 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 476213001103 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 476213001104 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 476213001105 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 476213001106 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 476213001107 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 476213001108 DNA binding site [nucleotide binding] 476213001109 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 476213001110 DNA binding residues [nucleotide binding] 476213001111 dimerization interface [polypeptide binding]; other site 476213001112 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 476213001113 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 476213001114 Outer membrane efflux protein; Region: OEP; pfam02321 476213001115 Outer membrane efflux protein; Region: OEP; pfam02321 476213001116 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 476213001117 MMPL family; Region: MMPL; cl14618 476213001118 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 476213001119 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 476213001120 HlyD family secretion protein; Region: HlyD_3; pfam13437 476213001121 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 476213001122 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 476213001123 metal-binding site [ion binding] 476213001124 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 476213001125 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 476213001126 motif II; other site 476213001127 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 476213001128 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 476213001129 DNA binding residues [nucleotide binding] 476213001130 dimer interface [polypeptide binding]; other site 476213001131 copper binding site [ion binding]; other site 476213001132 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 476213001133 metal-binding site [ion binding] 476213001134 putative sialic acid transporter; Region: 2A0112; TIGR00891 476213001135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213001136 putative substrate translocation pore; other site 476213001137 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 476213001138 DNA methylase; Region: N6_N4_Mtase; cl17433 476213001139 DNA methylase; Region: N6_N4_Mtase; pfam01555 476213001140 type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483 476213001141 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 476213001142 ATP binding site [chemical binding]; other site 476213001143 VRR-NUC domain; Region: VRR_NUC; pfam08774 476213001144 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 476213001145 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 476213001146 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 476213001147 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213001148 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 476213001149 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 476213001150 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 476213001151 N-terminal plug; other site 476213001152 ligand-binding site [chemical binding]; other site 476213001153 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 476213001154 hypothetical protein; Provisional; Region: PRK09929 476213001155 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 476213001156 Propionate catabolism activator; Region: PrpR_N; pfam06506 476213001157 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 476213001158 Walker A motif; other site 476213001159 ATP binding site [chemical binding]; other site 476213001160 Walker B motif; other site 476213001161 arginine finger; other site 476213001162 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 476213001163 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 476213001164 tetramer interface [polypeptide binding]; other site 476213001165 active site 476213001166 Mg2+/Mn2+ binding site [ion binding]; other site 476213001167 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 476213001168 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 476213001169 dimer interface [polypeptide binding]; other site 476213001170 active site 476213001171 citrylCoA binding site [chemical binding]; other site 476213001172 oxalacetate/citrate binding site [chemical binding]; other site 476213001173 coenzyme A binding site [chemical binding]; other site 476213001174 catalytic triad [active] 476213001175 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 476213001176 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 476213001177 dimer interface [polypeptide binding]; other site 476213001178 active site 476213001179 Schiff base residues; other site 476213001180 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 476213001181 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 476213001182 Autotransporter beta-domain; Region: Autotransporter; smart00869 476213001183 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 476213001184 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 476213001185 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 476213001186 ligand binding site [chemical binding]; other site 476213001187 flexible hinge region; other site 476213001188 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 476213001189 microcin B17 transporter; Reviewed; Region: PRK11098 476213001190 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 476213001191 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 476213001192 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 476213001193 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 476213001194 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 476213001195 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 476213001196 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 476213001197 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 476213001198 drug efflux system protein MdtG; Provisional; Region: PRK09874 476213001199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213001200 putative substrate translocation pore; other site 476213001201 anti-RssB factor; Provisional; Region: PRK10244 476213001202 hypothetical protein; Provisional; Region: PRK11505 476213001203 psiF repeat; Region: PsiF_repeat; pfam07769 476213001204 psiF repeat; Region: PsiF_repeat; pfam07769 476213001205 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 476213001206 MASE2 domain; Region: MASE2; pfam05230 476213001207 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 476213001208 metal binding site [ion binding]; metal-binding site 476213001209 active site 476213001210 I-site; other site 476213001211 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 476213001212 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 476213001213 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 476213001214 hypothetical protein; Validated; Region: PRK00124 476213001215 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 476213001216 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 476213001217 ADP binding site [chemical binding]; other site 476213001218 magnesium binding site [ion binding]; other site 476213001219 putative shikimate binding site; other site 476213001220 hypothetical protein; Provisional; Region: PRK10380 476213001221 hypothetical protein; Provisional; Region: PRK10481 476213001222 hypothetical protein; Provisional; Region: PRK10579 476213001223 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 476213001224 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 476213001225 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 476213001226 nucleotide binding site [chemical binding]; other site 476213001227 MFS transport protein AraJ; Provisional; Region: PRK10091 476213001228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213001229 putative substrate translocation pore; other site 476213001230 exonuclease subunit SbcC; Provisional; Region: PRK10246 476213001231 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 476213001232 Walker A/P-loop; other site 476213001233 ATP binding site [chemical binding]; other site 476213001234 Q-loop/lid; other site 476213001235 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 476213001236 ABC transporter signature motif; other site 476213001237 Walker B; other site 476213001238 D-loop; other site 476213001239 H-loop/switch region; other site 476213001240 exonuclease subunit SbcD; Provisional; Region: PRK10966 476213001241 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 476213001242 active site 476213001243 metal binding site [ion binding]; metal-binding site 476213001244 DNA binding site [nucleotide binding] 476213001245 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 476213001246 transcriptional regulator PhoB; Provisional; Region: PRK10161 476213001247 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 476213001248 active site 476213001249 phosphorylation site [posttranslational modification] 476213001250 intermolecular recognition site; other site 476213001251 dimerization interface [polypeptide binding]; other site 476213001252 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 476213001253 DNA binding site [nucleotide binding] 476213001254 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 476213001255 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 476213001256 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 476213001257 putative active site [active] 476213001258 heme pocket [chemical binding]; other site 476213001259 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 476213001260 dimer interface [polypeptide binding]; other site 476213001261 phosphorylation site [posttranslational modification] 476213001262 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 476213001263 ATP binding site [chemical binding]; other site 476213001264 Mg2+ binding site [ion binding]; other site 476213001265 G-X-G motif; other site 476213001266 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 476213001267 putative proline-specific permease; Provisional; Region: proY; PRK10580 476213001268 Spore germination protein; Region: Spore_permease; cl17796 476213001269 maltodextrin glucosidase; Provisional; Region: PRK10785 476213001270 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 476213001271 homodimer interface [polypeptide binding]; other site 476213001272 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 476213001273 active site 476213001274 homodimer interface [polypeptide binding]; other site 476213001275 catalytic site [active] 476213001276 peroxidase; Provisional; Region: PRK15000 476213001277 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 476213001278 dimer interface [polypeptide binding]; other site 476213001279 decamer (pentamer of dimers) interface [polypeptide binding]; other site 476213001280 catalytic triad [active] 476213001281 peroxidatic and resolving cysteines [active] 476213001282 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 476213001283 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 476213001284 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 476213001285 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 476213001286 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 476213001287 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 476213001288 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 476213001289 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 476213001290 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 476213001291 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 476213001292 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 476213001293 Protein export membrane protein; Region: SecD_SecF; pfam02355 476213001294 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 476213001295 Predicted transcriptional regulator [Transcription]; Region: COG2378 476213001296 HTH domain; Region: HTH_11; pfam08279 476213001297 WYL domain; Region: WYL; pfam13280 476213001298 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 476213001299 active site 476213001300 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 476213001301 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 476213001302 hypothetical protein; Provisional; Region: PRK11530 476213001303 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 476213001304 ATP cone domain; Region: ATP-cone; pfam03477 476213001305 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 476213001306 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 476213001307 catalytic motif [active] 476213001308 Zn binding site [ion binding]; other site 476213001309 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 476213001310 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 476213001311 homopentamer interface [polypeptide binding]; other site 476213001312 active site 476213001313 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 476213001314 thiamine monophosphate kinase; Provisional; Region: PRK05731 476213001315 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 476213001316 ATP binding site [chemical binding]; other site 476213001317 dimerization interface [polypeptide binding]; other site 476213001318 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 476213001319 tetramer interfaces [polypeptide binding]; other site 476213001320 binuclear metal-binding site [ion binding]; other site 476213001321 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 476213001322 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 476213001323 active site 476213001324 catalytic tetrad [active] 476213001325 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 476213001326 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 476213001327 TPP-binding site; other site 476213001328 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 476213001329 PYR/PP interface [polypeptide binding]; other site 476213001330 dimer interface [polypeptide binding]; other site 476213001331 TPP binding site [chemical binding]; other site 476213001332 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 476213001333 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 476213001334 substrate binding pocket [chemical binding]; other site 476213001335 chain length determination region; other site 476213001336 active site lid residues [active] 476213001337 substrate-Mg2+ binding site; other site 476213001338 catalytic residues [active] 476213001339 aspartate-rich region 1; other site 476213001340 aspartate-rich region 2; other site 476213001341 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 476213001342 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 476213001343 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 476213001344 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 476213001345 Ligand Binding Site [chemical binding]; other site 476213001346 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 476213001347 active site residue [active] 476213001348 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 476213001349 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213001350 dimer interface [polypeptide binding]; other site 476213001351 conserved gate region; other site 476213001352 putative PBP binding loops; other site 476213001353 ABC-ATPase subunit interface; other site 476213001354 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 476213001355 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213001356 dimer interface [polypeptide binding]; other site 476213001357 conserved gate region; other site 476213001358 putative PBP binding loops; other site 476213001359 ABC-ATPase subunit interface; other site 476213001360 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 476213001361 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate binding protein; Region: PhnS; TIGR03227 476213001362 transcriptional regulator protein; Region: phnR; TIGR03337 476213001363 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 476213001364 DNA-binding site [nucleotide binding]; DNA binding site 476213001365 UTRA domain; Region: UTRA; pfam07702 476213001366 2-aminoethylphosphonate--pyruvate transaminase; Region: transamin_PhnW; TIGR02326 476213001367 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 476213001368 catalytic residue [active] 476213001369 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 476213001370 phosphonoacetaldehyde hydrolase; Region: phosphonatase; TIGR01422 476213001371 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 476213001372 motif II; other site 476213001373 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 476213001374 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 476213001375 conserved cys residue [active] 476213001376 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 476213001377 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 476213001378 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 476213001379 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 476213001380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213001381 Major Facilitator Superfamily; Region: MFS_1; pfam07690 476213001382 putative substrate translocation pore; other site 476213001383 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; cl19914 476213001384 Sel1-like repeats; Region: SEL1; smart00671 476213001385 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 476213001386 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 476213001387 Sel1 repeat; Region: Sel1; pfam08238 476213001388 Sel1-like repeats; Region: SEL1; smart00671 476213001389 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 476213001390 Sel1-like repeats; Region: SEL1; smart00671 476213001391 Sel1-like repeats; Region: SEL1; smart00671 476213001392 Sel1-like repeats; Region: SEL1; smart00671 476213001393 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 476213001394 putative active site [active] 476213001395 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 476213001396 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 476213001397 Subunit III/IV interface [polypeptide binding]; other site 476213001398 Subunit I/III interface [polypeptide binding]; other site 476213001399 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 476213001400 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 476213001401 D-pathway; other site 476213001402 Putative ubiquinol binding site [chemical binding]; other site 476213001403 Low-spin heme (heme b) binding site [chemical binding]; other site 476213001404 Putative water exit pathway; other site 476213001405 Binuclear center (heme o3/CuB) [ion binding]; other site 476213001406 K-pathway; other site 476213001407 Putative proton exit pathway; other site 476213001408 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 476213001409 The cupredoxin domain of Ubiquinol oxidase subunit II; Region: CuRO_UO_II; cd04212 476213001410 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 476213001411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213001412 Major Facilitator Superfamily; Region: MFS_1; pfam07690 476213001413 putative substrate translocation pore; other site 476213001414 hypothetical protein; Provisional; Region: PRK11627 476213001415 trigger factor; Provisional; Region: tig; PRK01490 476213001416 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 476213001417 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 476213001418 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 476213001419 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 476213001420 oligomer interface [polypeptide binding]; other site 476213001421 active site residues [active] 476213001422 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 476213001423 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 476213001424 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 476213001425 Walker A motif; other site 476213001426 ATP binding site [chemical binding]; other site 476213001427 Walker B motif; other site 476213001428 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 476213001429 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 476213001430 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 476213001431 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 476213001432 Walker A motif; other site 476213001433 ATP binding site [chemical binding]; other site 476213001434 Walker B motif; other site 476213001435 arginine finger; other site 476213001436 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 476213001437 histone-like DNA-binding protein HU; Region: HU; cd13831 476213001438 dimer interface [polypeptide binding]; other site 476213001439 DNA binding site [nucleotide binding] 476213001440 periplasmic folding chaperone; Provisional; Region: PRK10788 476213001441 SurA N-terminal domain; Region: SurA_N_3; cl07813 476213001442 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 476213001443 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 476213001444 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 476213001445 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 476213001446 active site 476213001447 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 476213001448 Ligand Binding Site [chemical binding]; other site 476213001449 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 476213001450 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 476213001451 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 476213001452 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 476213001453 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 476213001454 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 476213001455 active site 476213001456 motif I; other site 476213001457 motif II; other site 476213001458 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 476213001459 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 476213001460 catalytic residue [active] 476213001461 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 476213001462 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 476213001463 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 476213001464 Walker A/P-loop; other site 476213001465 ATP binding site [chemical binding]; other site 476213001466 Q-loop/lid; other site 476213001467 ABC transporter signature motif; other site 476213001468 Walker B; other site 476213001469 D-loop; other site 476213001470 H-loop/switch region; other site 476213001471 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 476213001472 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 476213001473 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 476213001474 Walker A/P-loop; other site 476213001475 ATP binding site [chemical binding]; other site 476213001476 Q-loop/lid; other site 476213001477 ABC transporter signature motif; other site 476213001478 Walker B; other site 476213001479 D-loop; other site 476213001480 H-loop/switch region; other site 476213001481 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 476213001482 ammonium transporter; Provisional; Region: PRK10666 476213001483 acyl-CoA thioesterase II; Provisional; Region: PRK10526 476213001484 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 476213001485 active site 476213001486 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 476213001487 catalytic triad [active] 476213001488 dimer interface [polypeptide binding]; other site 476213001489 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 476213001490 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 476213001491 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 476213001492 DNA binding site [nucleotide binding] 476213001493 active site 476213001494 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 476213001495 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 476213001496 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 476213001497 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 476213001498 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 476213001499 Inner membrane protein YlaC; Region: YlaC; pfam10777 476213001500 maltose O-acetyltransferase; Provisional; Region: PRK10092 476213001501 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 476213001502 active site 476213001503 substrate binding site [chemical binding]; other site 476213001504 trimer interface [polypeptide binding]; other site 476213001505 CoA binding site [chemical binding]; other site 476213001506 gene expression modulator; Provisional; Region: PRK10945 476213001507 Hha toxicity attenuator; Provisional; Region: PRK10667 476213001508 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 476213001509 MMPL family; Region: MMPL; cl14618 476213001510 MMPL family; Region: MMPL; cl14618 476213001511 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 476213001512 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 476213001513 HlyD family secretion protein; Region: HlyD_3; pfam13437 476213001514 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 476213001515 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 476213001516 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 476213001517 hypothetical protein; Provisional; Region: PRK11281 476213001518 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 476213001519 Mechanosensitive ion channel; Region: MS_channel; pfam00924 476213001520 Uncharacterized conserved protein [Function unknown]; Region: COG5464 476213001521 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 476213001522 hypothetical protein; Provisional; Region: PRK11038 476213001523 primosomal replication protein N''; Provisional; Region: PRK10093 476213001524 hypothetical protein; Provisional; Region: PRK10527 476213001525 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 476213001526 active site 476213001527 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 476213001528 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 476213001529 Walker A motif; other site 476213001530 ATP binding site [chemical binding]; other site 476213001531 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 476213001532 Walker B motif; other site 476213001533 arginine finger; other site 476213001534 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 476213001535 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 476213001536 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 476213001537 hypothetical protein; Validated; Region: PRK00153 476213001538 recombination protein RecR; Reviewed; Region: recR; PRK00076 476213001539 RecR protein; Region: RecR; pfam02132 476213001540 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 476213001541 putative active site [active] 476213001542 putative metal-binding site [ion binding]; other site 476213001543 tetramer interface [polypeptide binding]; other site 476213001544 heat shock protein 90; Provisional; Region: PRK05218 476213001545 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 476213001546 ATP binding site [chemical binding]; other site 476213001547 Mg2+ binding site [ion binding]; other site 476213001548 G-X-G motif; other site 476213001549 Hsp90 protein; Region: HSP90; pfam00183 476213001550 adenylate kinase; Reviewed; Region: adk; PRK00279 476213001551 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 476213001552 AMP-binding site [chemical binding]; other site 476213001553 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 476213001554 ferrochelatase; Reviewed; Region: hemH; PRK00035 476213001555 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 476213001556 C-terminal domain interface [polypeptide binding]; other site 476213001557 active site 476213001558 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 476213001559 active site 476213001560 N-terminal domain interface [polypeptide binding]; other site 476213001561 acetyl esterase; Provisional; Region: PRK10162 476213001562 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 476213001563 inosine/guanosine kinase; Provisional; Region: PRK15074 476213001564 substrate binding site [chemical binding]; other site 476213001565 ATP binding site [chemical binding]; other site 476213001566 putative cation:proton antiport protein; Provisional; Region: PRK10669 476213001567 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 476213001568 TrkA-N domain; Region: TrkA_N; pfam02254 476213001569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213001570 Major Facilitator Superfamily; Region: MFS_1; pfam07690 476213001571 putative substrate translocation pore; other site 476213001572 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 476213001573 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 476213001574 active site 476213001575 metal binding site [ion binding]; metal-binding site 476213001576 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 476213001577 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 476213001578 putative deacylase active site [active] 476213001579 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 476213001580 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 476213001581 copper exporting ATPase; Provisional; Region: copA; PRK10671 476213001582 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 476213001583 metal-binding site [ion binding] 476213001584 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 476213001585 metal-binding site [ion binding] 476213001586 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 476213001587 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 476213001588 motif II; other site 476213001589 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 476213001590 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 476213001591 DNA binding residues [nucleotide binding] 476213001592 dimer interface [polypeptide binding]; other site 476213001593 copper binding site [ion binding]; other site 476213001594 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 476213001595 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 476213001596 Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829 476213001597 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 476213001598 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 476213001599 Walker A/P-loop; other site 476213001600 ATP binding site [chemical binding]; other site 476213001601 Q-loop/lid; other site 476213001602 ABC transporter signature motif; other site 476213001603 Walker B; other site 476213001604 D-loop; other site 476213001605 H-loop/switch region; other site 476213001606 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 476213001607 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 476213001608 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 476213001609 Tetratricopeptide repeat; Region: TPR_20; pfam14561 476213001610 short chain dehydrogenase; Validated; Region: PRK06182 476213001611 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 476213001612 NADP binding site [chemical binding]; other site 476213001613 active site 476213001614 steroid binding site; other site 476213001615 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 476213001616 active site 476213001617 catalytic triad [active] 476213001618 oxyanion hole [active] 476213001619 switch loop; other site 476213001620 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 476213001621 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 476213001622 Walker A/P-loop; other site 476213001623 ATP binding site [chemical binding]; other site 476213001624 Q-loop/lid; other site 476213001625 ABC transporter signature motif; other site 476213001626 Walker B; other site 476213001627 D-loop; other site 476213001628 H-loop/switch region; other site 476213001629 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 476213001630 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 476213001631 FtsX-like permease family; Region: FtsX; pfam02687 476213001632 FtsX-like permease family; Region: FtsX; pfam02687 476213001633 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 476213001634 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 476213001635 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 476213001636 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 476213001637 Walker A/P-loop; other site 476213001638 ATP binding site [chemical binding]; other site 476213001639 Q-loop/lid; other site 476213001640 ABC transporter signature motif; other site 476213001641 Walker B; other site 476213001642 D-loop; other site 476213001643 H-loop/switch region; other site 476213001644 NIL domain; Region: NIL; pfam09383 476213001645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213001646 dimer interface [polypeptide binding]; other site 476213001647 conserved gate region; other site 476213001648 putative PBP binding loops; other site 476213001649 ABC-ATPase subunit interface; other site 476213001650 Predicted ATPase [General function prediction only]; Region: COG2603 476213001651 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 476213001652 active site residue [active] 476213001653 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 476213001654 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213001655 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 476213001656 dimerization interface [polypeptide binding]; other site 476213001657 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 476213001658 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 476213001659 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 476213001660 Bacterial transcriptional regulator; Region: IclR; pfam01614 476213001661 glyoxylate carboligase; Provisional; Region: PRK11269 476213001662 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 476213001663 PYR/PP interface [polypeptide binding]; other site 476213001664 dimer interface [polypeptide binding]; other site 476213001665 TPP binding site [chemical binding]; other site 476213001666 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 476213001667 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 476213001668 TPP-binding site [chemical binding]; other site 476213001669 hydroxypyruvate isomerase; Provisional; Region: PRK09997 476213001670 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 476213001671 tartronate semialdehyde reductase; Provisional; Region: PRK15059 476213001672 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 476213001673 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 476213001674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213001675 Major Facilitator Superfamily; Region: MFS_1; pfam07690 476213001676 putative substrate translocation pore; other site 476213001677 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 476213001678 Na binding site [ion binding]; other site 476213001679 putative substrate binding site [chemical binding]; other site 476213001680 allantoinase; Provisional; Region: PRK08044 476213001681 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 476213001682 active site 476213001683 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 476213001684 putative uracil/xanthine transporter; Provisional; Region: PRK11412 476213001685 glycerate kinase II; Provisional; Region: PRK09932 476213001686 Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257 476213001687 Mif2/CENP-C like; Region: CENP-C_C; pfam11699 476213001688 Cupin domain; Region: Cupin_2; cl17218 476213001689 allantoate amidohydrolase; Region: AllC; TIGR03176 476213001690 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 476213001691 active site 476213001692 metal binding site [ion binding]; metal-binding site 476213001693 dimer interface [polypeptide binding]; other site 476213001694 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 476213001695 membrane protein FdrA; Validated; Region: PRK06091 476213001696 CoA binding domain; Region: CoA_binding; pfam02629 476213001697 CoA-ligase; Region: Ligase_CoA; pfam00549 476213001698 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 476213001699 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 476213001700 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 476213001701 putative substrate binding site [chemical binding]; other site 476213001702 nucleotide binding site [chemical binding]; other site 476213001703 nucleotide binding site [chemical binding]; other site 476213001704 homodimer interface [polypeptide binding]; other site 476213001705 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 476213001706 ATP-grasp domain; Region: ATP-grasp_4; cl17255 476213001707 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 476213001708 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 476213001709 putative active site [active] 476213001710 putative metal binding site [ion binding]; other site 476213001711 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 476213001712 substrate binding site [chemical binding]; other site 476213001713 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 476213001714 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 476213001715 active site 476213001716 HIGH motif; other site 476213001717 KMSKS motif; other site 476213001718 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 476213001719 tRNA binding surface [nucleotide binding]; other site 476213001720 anticodon binding site; other site 476213001721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4727 476213001722 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 476213001723 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 476213001724 RNA binding surface [nucleotide binding]; other site 476213001725 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 476213001726 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 476213001727 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 476213001728 homodimer interface [polypeptide binding]; other site 476213001729 NADP binding site [chemical binding]; other site 476213001730 substrate binding site [chemical binding]; other site 476213001731 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 476213001732 fimbrial protein FimI; Provisional; Region: PRK15200 476213001733 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 476213001734 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 476213001735 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 476213001736 outer membrane usher protein FimD; Provisional; Region: PRK15198 476213001737 PapC N-terminal domain; Region: PapC_N; pfam13954 476213001738 Outer membrane usher protein; Region: Usher; pfam00577 476213001739 PapC C-terminal domain; Region: PapC_C; pfam13953 476213001740 fimbrial-like adhesin; Provisional; Region: fimH; PRK15199 476213001741 fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934 476213001742 putative diguanylate cyclase; Provisional; Region: PRK13561 476213001743 fimbriae regulatory protein FimW; Provisional; Region: PRK15201 476213001744 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 476213001745 DNA binding residues [nucleotide binding] 476213001746 dimerization interface [polypeptide binding]; other site 476213001747 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 476213001748 Transposase, Mutator family; Region: Transposase_mut; cl19537 476213001749 Predicted membrane protein [Function unknown]; Region: COG2246 476213001750 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 476213001751 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 476213001752 Ligand binding site; other site 476213001753 Putative Catalytic site; other site 476213001754 DXD motif; other site 476213001755 Transposase, Mutator family; Region: Transposase_mut; cl19537 476213001756 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 476213001757 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 476213001758 Transposase, Mutator family; Region: Transposase_mut; cl19537 476213001759 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 476213001760 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 476213001761 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 476213001762 Ligand binding site; other site 476213001763 Putative Catalytic site; other site 476213001764 DXD motif; other site 476213001765 Predicted membrane protein [Function unknown]; Region: COG2246 476213001766 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 476213001767 ATP binding site [chemical binding]; other site 476213001768 Mg2+ binding site [ion binding]; other site 476213001769 G-X-G motif; other site 476213001770 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 476213001771 Squalene epoxidase; Region: SE; cl17314 476213001772 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 476213001773 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 476213001774 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 476213001775 Predicted membrane protein [Function unknown]; Region: COG3059 476213001776 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 476213001777 phenylalanine transporter; Provisional; Region: PRK10249 476213001778 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 476213001779 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 476213001780 Mechanosensitive ion channel; Region: MS_channel; pfam00924 476213001781 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 476213001782 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 476213001783 active site 476213001784 catalytic triad [active] 476213001785 oxyanion hole [active] 476213001786 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 476213001787 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 476213001788 dimer interface [polypeptide binding]; other site 476213001789 FMN binding site [chemical binding]; other site 476213001790 hypothetical protein; Provisional; Region: PRK10250 476213001791 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 476213001792 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 476213001793 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 476213001794 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213001795 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213001796 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 476213001797 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 476213001798 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 476213001799 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 476213001800 outer membrane receptor FepA; Provisional; Region: PRK13524 476213001801 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 476213001802 N-terminal plug; other site 476213001803 ligand-binding site [chemical binding]; other site 476213001804 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 476213001805 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 476213001806 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 476213001807 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 476213001808 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 476213001809 Condensation domain; Region: Condensation; cl19241 476213001810 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 476213001811 acyl-activating enzyme (AAE) consensus motif; other site 476213001812 AMP binding site [chemical binding]; other site 476213001813 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 476213001814 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 476213001815 LPS O-antigen length regulator; Provisional; Region: PRK10381 476213001816 Chain length determinant protein; Region: Wzz; pfam02706 476213001817 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 476213001818 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 476213001819 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 476213001820 Walker A/P-loop; other site 476213001821 ATP binding site [chemical binding]; other site 476213001822 Q-loop/lid; other site 476213001823 ABC transporter signature motif; other site 476213001824 Walker B; other site 476213001825 D-loop; other site 476213001826 H-loop/switch region; other site 476213001827 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 476213001828 ABC-ATPase subunit interface; other site 476213001829 dimer interface [polypeptide binding]; other site 476213001830 putative PBP binding regions; other site 476213001831 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 476213001832 ABC-ATPase subunit interface; other site 476213001833 dimer interface [polypeptide binding]; other site 476213001834 putative PBP binding regions; other site 476213001835 enterobactin exporter EntS; Provisional; Region: PRK10489 476213001836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213001837 putative substrate translocation pore; other site 476213001838 ABC-type Fe2+-enterobactin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG4592 476213001839 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 476213001840 siderophore binding site; other site 476213001841 isochorismate synthase EntC; Provisional; Region: PRK15016 476213001842 chorismate binding enzyme; Region: Chorismate_bind; cl10555 476213001843 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 476213001844 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 476213001845 acyl-activating enzyme (AAE) consensus motif; other site 476213001846 active site 476213001847 AMP binding site [chemical binding]; other site 476213001848 substrate binding site [chemical binding]; other site 476213001849 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 476213001850 hydrophobic substrate binding pocket; other site 476213001851 active site 476213001852 conserved cis-peptide bond; other site 476213001853 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 476213001854 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 476213001855 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 476213001856 putative NAD(P) binding site [chemical binding]; other site 476213001857 active site 476213001858 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 476213001859 CoenzymeA binding site [chemical binding]; other site 476213001860 subunit interaction site [polypeptide binding]; other site 476213001861 PHB binding site; other site 476213001862 carbon starvation protein A; Provisional; Region: PRK15015 476213001863 Carbon starvation protein CstA; Region: CstA; pfam02554 476213001864 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 476213001865 Uncharacterized small protein [Function unknown]; Region: COG2879 476213001866 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 476213001867 putative active site [active] 476213001868 metal binding site [ion binding]; metal-binding site 476213001869 methionine aminotransferase; Validated; Region: PRK09082 476213001870 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 476213001871 pyridoxal 5'-phosphate binding site [chemical binding]; other site 476213001872 homodimer interface [polypeptide binding]; other site 476213001873 catalytic residue [active] 476213001874 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 476213001875 ParB-like nuclease domain; Region: ParBc; pfam02195 476213001876 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 476213001877 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 476213001878 Active Sites [active] 476213001879 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 476213001880 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 476213001881 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213001882 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 476213001883 dimerization interface [polypeptide binding]; other site 476213001884 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 476213001885 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 476213001886 dimerization domain [polypeptide binding]; other site 476213001887 dimer interface [polypeptide binding]; other site 476213001888 catalytic residues [active] 476213001889 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 476213001890 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 476213001891 dimer interface [polypeptide binding]; other site 476213001892 decamer (pentamer of dimers) interface [polypeptide binding]; other site 476213001893 catalytic triad [active] 476213001894 peroxidatic and resolving cysteines [active] 476213001895 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 476213001896 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 476213001897 catalytic residue [active] 476213001898 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 476213001899 catalytic residues [active] 476213001900 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 476213001901 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 476213001902 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 476213001903 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 476213001904 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 476213001905 putative [4Fe-4S] binding site [ion binding]; other site 476213001906 putative molybdopterin cofactor binding site [chemical binding]; other site 476213001907 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 476213001908 molybdopterin cofactor binding site; other site 476213001909 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 476213001910 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 476213001911 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 476213001912 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 476213001913 Ligand Binding Site [chemical binding]; other site 476213001914 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 476213001915 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 476213001916 NAD binding site [chemical binding]; other site 476213001917 catalytic Zn binding site [ion binding]; other site 476213001918 structural Zn binding site [ion binding]; other site 476213001919 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 476213001920 Rnk N-terminus; Region: Rnk_N; pfam14760 476213001921 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 476213001922 anion transporter; Region: dass; TIGR00785 476213001923 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 476213001924 transmembrane helices; other site 476213001925 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 476213001926 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 476213001927 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 476213001928 Coenzyme A transferase; Region: CoA_trans; cl17247 476213001929 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 476213001930 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 476213001931 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 476213001932 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 476213001933 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 476213001934 putative active site [active] 476213001935 (T/H)XGH motif; other site 476213001936 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 476213001937 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 476213001938 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 476213001939 putative active site [active] 476213001940 heme pocket [chemical binding]; other site 476213001941 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 476213001942 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 476213001943 ATP binding site [chemical binding]; other site 476213001944 Mg2+ binding site [ion binding]; other site 476213001945 G-X-G motif; other site 476213001946 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 476213001947 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 476213001948 active site 476213001949 phosphorylation site [posttranslational modification] 476213001950 intermolecular recognition site; other site 476213001951 dimerization interface [polypeptide binding]; other site 476213001952 Transcriptional regulator; Region: CitT; pfam12431 476213001953 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 476213001954 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 476213001955 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 476213001956 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 476213001957 DNA-binding site [nucleotide binding]; DNA binding site 476213001958 RNA-binding motif; other site 476213001959 chromosome condensation membrane protein; Provisional; Region: PRK14196 476213001960 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 476213001961 putative active site [active] 476213001962 catalytic triad [active] 476213001963 putative dimer interface [polypeptide binding]; other site 476213001964 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 476213001965 lipoyl synthase; Provisional; Region: PRK05481 476213001966 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 476213001967 FeS/SAM binding site; other site 476213001968 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 476213001969 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213001970 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 476213001971 dimerization interface [polypeptide binding]; other site 476213001972 lipoate-protein ligase B; Provisional; Region: PRK14342 476213001973 hypothetical protein; Provisional; Region: PRK04998 476213001974 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 476213001975 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 476213001976 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 476213001977 rare lipoprotein A; Provisional; Region: PRK10672 476213001978 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 476213001979 Sporulation related domain; Region: SPOR; pfam05036 476213001980 cell wall shape-determining protein; Provisional; Region: PRK10794 476213001981 penicillin-binding protein 2; Provisional; Region: PRK10795 476213001982 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 476213001983 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 476213001984 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 476213001985 ribosome-associated protein; Provisional; Region: PRK11538 476213001986 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 476213001987 catalytic core [active] 476213001988 threonine-phosphate decarboxylase; Provisional; Region: PRK08056 476213001989 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 476213001990 pyridoxal 5'-phosphate binding site [chemical binding]; other site 476213001991 homodimer interface [polypeptide binding]; other site 476213001992 catalytic residue [active] 476213001993 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 476213001994 active site 476213001995 (T/H)XGH motif; other site 476213001996 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 476213001997 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 476213001998 Processivity clamp loader gamma complex DNA pol III C-term; Region: DNA_pol3_delt_C; pfam14840 476213001999 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 476213002000 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 476213002001 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 476213002002 active site 476213002003 HIGH motif; other site 476213002004 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 476213002005 KMSKS motif; other site 476213002006 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 476213002007 tRNA binding surface [nucleotide binding]; other site 476213002008 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 476213002009 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 476213002010 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 476213002011 Propionate catabolism activator; Region: PrpR_N; pfam06506 476213002012 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 476213002013 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 476213002014 Walker A motif; other site 476213002015 ATP binding site [chemical binding]; other site 476213002016 Walker B motif; other site 476213002017 arginine finger; other site 476213002018 hypothetical protein; Provisional; Region: PRK11032 476213002019 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 476213002020 Sel1-like repeats; Region: SEL1; smart00671 476213002021 Sel1-like repeats; Region: SEL1; smart00671 476213002022 Sel1-like repeats; Region: SEL1; smart00671 476213002023 Sel1-like repeats; Region: SEL1; smart00671 476213002024 Sel1-like repeats; Region: SEL1; smart00671 476213002025 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 476213002026 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 476213002027 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 476213002028 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 476213002029 nucleotide binding site [chemical binding]; other site 476213002030 putative NEF/HSP70 interaction site [polypeptide binding]; other site 476213002031 SBD interface [polypeptide binding]; other site 476213002032 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 476213002033 active site 476213002034 tetramer interface [polypeptide binding]; other site 476213002035 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 476213002036 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 476213002037 Walker A/P-loop; other site 476213002038 ATP binding site [chemical binding]; other site 476213002039 Q-loop/lid; other site 476213002040 ABC transporter signature motif; other site 476213002041 Walker B; other site 476213002042 D-loop; other site 476213002043 H-loop/switch region; other site 476213002044 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 476213002045 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213002046 dimer interface [polypeptide binding]; other site 476213002047 conserved gate region; other site 476213002048 putative PBP binding loops; other site 476213002049 ABC-ATPase subunit interface; other site 476213002050 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 476213002051 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213002052 dimer interface [polypeptide binding]; other site 476213002053 conserved gate region; other site 476213002054 putative PBP binding loops; other site 476213002055 ABC-ATPase subunit interface; other site 476213002056 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 476213002057 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 476213002058 substrate binding pocket [chemical binding]; other site 476213002059 membrane-bound complex binding site; other site 476213002060 hinge residues; other site 476213002061 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl19164 476213002062 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 476213002063 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 476213002064 putative active site [active] 476213002065 catalytic triad [active] 476213002066 putative dimer interface [polypeptide binding]; other site 476213002067 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 476213002068 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 476213002069 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 476213002070 Transporter associated domain; Region: CorC_HlyC; smart01091 476213002071 metal-binding heat shock protein; Provisional; Region: PRK00016 476213002072 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 476213002073 PhoH-like protein; Region: PhoH; pfam02562 476213002074 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 476213002075 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 476213002076 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 476213002077 FeS/SAM binding site; other site 476213002078 TRAM domain; Region: TRAM; pfam01938 476213002079 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 476213002080 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 476213002081 asparagine synthetase B; Provisional; Region: asnB; PRK09431 476213002082 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 476213002083 active site 476213002084 dimer interface [polypeptide binding]; other site 476213002085 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 476213002086 Ligand Binding Site [chemical binding]; other site 476213002087 Molecular Tunnel; other site 476213002088 UMP phosphatase; Provisional; Region: PRK10444 476213002089 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 476213002090 active site 476213002091 motif I; other site 476213002092 motif II; other site 476213002093 MarR family; Region: MarR_2; cl17246 476213002094 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 476213002095 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 476213002096 nucleotide binding site [chemical binding]; other site 476213002097 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 476213002098 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 476213002099 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 476213002100 active site 476213002101 dimer interface [polypeptide binding]; other site 476213002102 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 476213002103 active site 476213002104 trimer interface [polypeptide binding]; other site 476213002105 allosteric site; other site 476213002106 active site lid [active] 476213002107 hexamer (dimer of trimers) interface [polypeptide binding]; other site 476213002108 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 476213002109 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 476213002110 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 476213002111 active site turn [active] 476213002112 phosphorylation site [posttranslational modification] 476213002113 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 476213002114 HPr interaction site; other site 476213002115 glycerol kinase (GK) interaction site [polypeptide binding]; other site 476213002116 active site 476213002117 phosphorylation site [posttranslational modification] 476213002118 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 476213002119 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 476213002120 active site 476213002121 HIGH motif; other site 476213002122 KMSKS motif; other site 476213002123 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 476213002124 outer membrane porin, OprD family; Region: OprD; pfam03573 476213002125 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 476213002126 YbfN-like lipoprotein; Region: YbfN; pfam13982 476213002127 citrate-proton symporter; Provisional; Region: PRK15075 476213002128 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213002129 putative substrate translocation pore; other site 476213002130 tricarballylate utilization protein B; Provisional; Region: PRK15033 476213002131 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 476213002132 tricarballylate dehydrogenase; Validated; Region: PRK08274 476213002133 precorrin 3B synthase CobZ; Region: CobZ_N-term; TIGR02485 476213002134 Transcriptional regulator [Transcription]; Region: LysR; COG0583 476213002135 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213002136 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 476213002137 dimerization interface [polypeptide binding]; other site 476213002138 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 476213002139 metal binding site 2 [ion binding]; metal-binding site 476213002140 putative DNA binding helix; other site 476213002141 metal binding site 1 [ion binding]; metal-binding site 476213002142 dimer interface [polypeptide binding]; other site 476213002143 structural Zn2+ binding site [ion binding]; other site 476213002144 flavodoxin FldA; Validated; Region: PRK09267 476213002145 LexA regulated protein; Provisional; Region: PRK11675 476213002146 acyl-CoA esterase; Provisional; Region: PRK10673 476213002147 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 476213002148 replication initiation regulator SeqA; Provisional; Region: PRK11187 476213002149 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 476213002150 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 476213002151 active site 476213002152 substrate binding site [chemical binding]; other site 476213002153 metal binding site [ion binding]; metal-binding site 476213002154 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 476213002155 putrescine transporter; Provisional; Region: potE; PRK10655 476213002156 ornithine decarboxylase; Provisional; Region: PRK13578 476213002157 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 476213002158 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 476213002159 homodimer interface [polypeptide binding]; other site 476213002160 pyridoxal 5'-phosphate binding site [chemical binding]; other site 476213002161 catalytic residue [active] 476213002162 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 476213002163 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 476213002164 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 476213002165 active site 476213002166 phosphorylation site [posttranslational modification] 476213002167 intermolecular recognition site; other site 476213002168 dimerization interface [polypeptide binding]; other site 476213002169 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 476213002170 DNA binding site [nucleotide binding] 476213002171 sensor protein KdpD; Provisional; Region: PRK10490 476213002172 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 476213002173 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 476213002174 Ligand Binding Site [chemical binding]; other site 476213002175 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 476213002176 GAF domain; Region: GAF_3; pfam13492 476213002177 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 476213002178 dimer interface [polypeptide binding]; other site 476213002179 phosphorylation site [posttranslational modification] 476213002180 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 476213002181 ATP binding site [chemical binding]; other site 476213002182 Mg2+ binding site [ion binding]; other site 476213002183 G-X-G motif; other site 476213002184 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 476213002185 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 476213002186 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 476213002187 Soluble P-type ATPase [General function prediction only]; Region: COG4087 476213002188 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 476213002189 potassium-transporting ATPase subunit F; Provisional; Region: kdpF; PRK14748 476213002190 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 476213002191 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 476213002192 DNA photolyase; Region: DNA_photolyase; pfam00875 476213002193 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 476213002194 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 476213002195 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213002196 putative substrate translocation pore; other site 476213002197 metal-binding protein; Provisional; Region: PRK10799 476213002198 Allophanate hydrolase subunit 1; Region: AHS1; cl19310 476213002199 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 476213002200 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 476213002201 putative active site [active] 476213002202 endonuclease VIII; Provisional; Region: PRK10445 476213002203 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 476213002204 DNA binding site [nucleotide binding] 476213002205 catalytic residue [active] 476213002206 putative catalytic residues [active] 476213002207 H2TH interface [polypeptide binding]; other site 476213002208 intercalation triad [nucleotide binding]; other site 476213002209 substrate specificity determining residue; other site 476213002210 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 476213002211 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 476213002212 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 476213002213 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 476213002214 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 476213002215 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 476213002216 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 476213002217 dimer interface [polypeptide binding]; other site 476213002218 active site 476213002219 citrylCoA binding site [chemical binding]; other site 476213002220 NADH binding [chemical binding]; other site 476213002221 cationic pore residues; other site 476213002222 oxalacetate/citrate binding site [chemical binding]; other site 476213002223 coenzyme A binding site [chemical binding]; other site 476213002224 catalytic triad [active] 476213002225 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 476213002226 Iron-sulfur protein interface; other site 476213002227 proximal quinone binding site [chemical binding]; other site 476213002228 SdhD (CybS) interface [polypeptide binding]; other site 476213002229 proximal heme binding site [chemical binding]; other site 476213002230 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 476213002231 SdhC subunit interface [polypeptide binding]; other site 476213002232 proximal heme binding site [chemical binding]; other site 476213002233 cardiolipin binding site; other site 476213002234 Iron-sulfur protein interface; other site 476213002235 proximal quinone binding site [chemical binding]; other site 476213002236 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 476213002237 L-aspartate oxidase; Provisional; Region: PRK06175 476213002238 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 476213002239 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 476213002240 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 476213002241 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 476213002242 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 476213002243 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 476213002244 TPP-binding site [chemical binding]; other site 476213002245 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 476213002246 dimer interface [polypeptide binding]; other site 476213002247 PYR/PP interface [polypeptide binding]; other site 476213002248 TPP binding site [chemical binding]; other site 476213002249 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 476213002250 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 476213002251 E3 interaction surface; other site 476213002252 lipoyl attachment site [posttranslational modification]; other site 476213002253 e3 binding domain; Region: E3_binding; pfam02817 476213002254 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 476213002255 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 476213002256 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 476213002257 CoA-ligase; Region: Ligase_CoA; pfam00549 476213002258 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 476213002259 CoA binding domain; Region: CoA_binding; pfam02629 476213002260 CoA-ligase; Region: Ligase_CoA; pfam00549 476213002261 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 476213002262 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 476213002263 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 476213002264 Predicted outer membrane lipoprotein [Function unknown]; Region: COG4890 476213002265 hypothetical protein; Provisional; Region: PRK10588 476213002266 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 476213002267 active site 476213002268 colicin uptake protein TolQ; Provisional; Region: PRK10801 476213002269 colicin uptake protein TolR; Provisional; Region: PRK11024 476213002270 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 476213002271 TolA C-terminal; Region: TolA; pfam06519 476213002272 translocation protein TolB; Provisional; Region: tolB; PRK03629 476213002273 TolB amino-terminal domain; Region: TolB_N; pfam04052 476213002274 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 476213002275 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 476213002276 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 476213002277 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 476213002278 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 476213002279 ligand binding site [chemical binding]; other site 476213002280 tol-pal system protein YbgF; Provisional; Region: PRK10803 476213002281 YfhG lipoprotein; Region: Lipoprotein_20; cl08141 476213002282 Tetratricopeptide repeat; Region: TPR_6; pfam13174 476213002283 Tetratricopeptide repeat; Region: TPR_6; pfam13174 476213002284 quinolinate synthetase; Provisional; Region: PRK09375 476213002285 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 476213002286 zinc transporter ZitB; Provisional; Region: PRK03557 476213002287 YbgS-like protein; Region: YbgS; pfam13985 476213002288 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 476213002289 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Region: FumA; COG1838 476213002290 fumarate hydratase; Provisional; Region: PRK06246 476213002291 Transcriptional regulator [Transcription]; Region: LysR; COG0583 476213002292 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213002293 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 476213002294 dimerization interface [polypeptide binding]; other site 476213002295 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 476213002296 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 476213002297 transmembrane helices; other site 476213002298 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 476213002299 oxaloacetate decarboxylase; Provisional; Region: PRK14040 476213002300 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 476213002301 active site 476213002302 catalytic residues [active] 476213002303 metal binding site [ion binding]; metal-binding site 476213002304 homodimer binding site [polypeptide binding]; other site 476213002305 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 476213002306 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 476213002307 carboxyltransferase (CT) interaction site; other site 476213002308 biotinylation site [posttranslational modification]; other site 476213002309 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15477 476213002310 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 476213002311 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 476213002312 ABC-ATPase subunit interface; other site 476213002313 dimer interface [polypeptide binding]; other site 476213002314 putative PBP binding regions; other site 476213002315 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 476213002316 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 476213002317 Walker A/P-loop; other site 476213002318 ATP binding site [chemical binding]; other site 476213002319 Q-loop/lid; other site 476213002320 ABC transporter signature motif; other site 476213002321 Walker B; other site 476213002322 D-loop; other site 476213002323 H-loop/switch region; other site 476213002324 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 476213002325 catalytic core [active] 476213002326 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 476213002327 active site 476213002328 catalytic residues [active] 476213002329 galactokinase; Provisional; Region: PRK05101 476213002330 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 476213002331 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 476213002332 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 476213002333 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 476213002334 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 476213002335 dimer interface [polypeptide binding]; other site 476213002336 active site 476213002337 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 476213002338 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 476213002339 NAD binding site [chemical binding]; other site 476213002340 homodimer interface [polypeptide binding]; other site 476213002341 active site 476213002342 substrate binding site [chemical binding]; other site 476213002343 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4714 476213002344 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 476213002345 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 476213002346 Walker A/P-loop; other site 476213002347 ATP binding site [chemical binding]; other site 476213002348 Q-loop/lid; other site 476213002349 ABC transporter signature motif; other site 476213002350 Walker B; other site 476213002351 D-loop; other site 476213002352 H-loop/switch region; other site 476213002353 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 476213002354 Walker A/P-loop; other site 476213002355 ATP binding site [chemical binding]; other site 476213002356 Q-loop/lid; other site 476213002357 ABC transporter signature motif; other site 476213002358 Walker B; other site 476213002359 D-loop; other site 476213002360 H-loop/switch region; other site 476213002361 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 476213002362 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 476213002363 molybdenum-pterin binding domain; Region: Mop; TIGR00638 476213002364 TOBE domain; Region: TOBE; pfam03459 476213002365 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 476213002366 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 476213002367 substrate binding pocket [chemical binding]; other site 476213002368 membrane-bound complex binding site; other site 476213002369 hinge residues; other site 476213002370 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 476213002371 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213002372 dimer interface [polypeptide binding]; other site 476213002373 conserved gate region; other site 476213002374 putative PBP binding loops; other site 476213002375 ABC-ATPase subunit interface; other site 476213002376 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 476213002377 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 476213002378 Walker A/P-loop; other site 476213002379 ATP binding site [chemical binding]; other site 476213002380 Q-loop/lid; other site 476213002381 ABC transporter signature motif; other site 476213002382 Walker B; other site 476213002383 D-loop; other site 476213002384 H-loop/switch region; other site 476213002385 molybdenum-pterin binding domain; Region: Mop; TIGR00638 476213002386 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 476213002387 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 476213002388 active site 476213002389 motif I; other site 476213002390 motif II; other site 476213002391 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 476213002392 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; cl17774 476213002393 6-phosphogluconolactonase; Provisional; Region: PRK11028 476213002394 acyl-CoA thioesterase; Provisional; Region: PRK10531 476213002395 Pectinesterase; Region: Pectinesterase; cl01911 476213002396 imidazolonepropionase; Validated; Region: PRK09356 476213002397 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 476213002398 active site 476213002399 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 476213002400 putative active site [active] 476213002401 putative metal binding site [ion binding]; other site 476213002402 histidine utilization repressor; Provisional; Region: PRK14999 476213002403 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 476213002404 DNA-binding site [nucleotide binding]; DNA binding site 476213002405 UTRA domain; Region: UTRA; pfam07702 476213002406 urocanate hydratase; Provisional; Region: PRK05414 476213002407 Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221 476213002408 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 476213002409 active sites [active] 476213002410 tetramer interface [polypeptide binding]; other site 476213002411 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 476213002412 substrate binding site [chemical binding]; other site 476213002413 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 476213002414 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 476213002415 inhibitor-cofactor binding pocket; inhibition site 476213002416 pyridoxal 5'-phosphate binding site [chemical binding]; other site 476213002417 catalytic residue [active] 476213002418 biotin synthase; Provisional; Region: PRK15108 476213002419 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 476213002420 FeS/SAM binding site; other site 476213002421 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 476213002422 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 476213002423 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 476213002424 substrate-cofactor binding pocket; other site 476213002425 pyridoxal 5'-phosphate binding site [chemical binding]; other site 476213002426 catalytic residue [active] 476213002427 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 476213002428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 476213002429 S-adenosylmethionine binding site [chemical binding]; other site 476213002430 AAA domain; Region: AAA_26; pfam13500 476213002431 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 476213002432 excinuclease ABC subunit B; Provisional; Region: PRK05298 476213002433 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 476213002434 ATP binding site [chemical binding]; other site 476213002435 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 476213002436 nucleotide binding region [chemical binding]; other site 476213002437 ATP-binding site [chemical binding]; other site 476213002438 Ultra-violet resistance protein B; Region: UvrB; pfam12344 476213002439 UvrB/uvrC motif; Region: UVR; pfam02151 476213002440 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 476213002441 phosphate binding site [ion binding]; other site 476213002442 putative substrate binding pocket [chemical binding]; other site 476213002443 dimer interface [polypeptide binding]; other site 476213002444 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 476213002445 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 476213002446 FeS/SAM binding site; other site 476213002447 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 476213002448 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 476213002449 MPT binding site; other site 476213002450 trimer interface [polypeptide binding]; other site 476213002451 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 476213002452 trimer interface [polypeptide binding]; other site 476213002453 dimer interface [polypeptide binding]; other site 476213002454 putative active site [active] 476213002455 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 476213002456 MoaE interaction surface [polypeptide binding]; other site 476213002457 MoeB interaction surface [polypeptide binding]; other site 476213002458 thiocarboxylated glycine; other site 476213002459 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 476213002460 MoaE homodimer interface [polypeptide binding]; other site 476213002461 MoaD interaction [polypeptide binding]; other site 476213002462 active site residues [active] 476213002463 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 476213002464 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 476213002465 Predicted integral membrane protein [Function unknown]; Region: COG0392 476213002466 cardiolipin synthase 2; Provisional; Region: PRK11263 476213002467 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 476213002468 putative active site [active] 476213002469 catalytic site [active] 476213002470 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 476213002471 putative active site [active] 476213002472 catalytic site [active] 476213002473 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 476213002474 putative catalytic site [active] 476213002475 putative metal binding site [ion binding]; other site 476213002476 putative phosphate binding site [ion binding]; other site 476213002477 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 476213002478 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 476213002479 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 476213002480 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 476213002481 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 476213002482 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 476213002483 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 476213002484 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 476213002485 Walker A/P-loop; other site 476213002486 ATP binding site [chemical binding]; other site 476213002487 Q-loop/lid; other site 476213002488 ABC transporter signature motif; other site 476213002489 Walker B; other site 476213002490 D-loop; other site 476213002491 H-loop/switch region; other site 476213002492 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 476213002493 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 476213002494 Walker A/P-loop; other site 476213002495 ATP binding site [chemical binding]; other site 476213002496 Q-loop/lid; other site 476213002497 ABC transporter signature motif; other site 476213002498 Walker B; other site 476213002499 D-loop; other site 476213002500 H-loop/switch region; other site 476213002501 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 476213002502 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 476213002503 HlyD family secretion protein; Region: HlyD_3; pfam13437 476213002504 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 476213002505 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 476213002506 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 476213002507 helicase 45; Provisional; Region: PTZ00424 476213002508 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 476213002509 ATP binding site [chemical binding]; other site 476213002510 Mg++ binding site [ion binding]; other site 476213002511 motif III; other site 476213002512 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 476213002513 nucleotide binding region [chemical binding]; other site 476213002514 ATP-binding site [chemical binding]; other site 476213002515 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 476213002516 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 476213002517 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 476213002518 glycosyl transferase family protein; Provisional; Region: PRK08136 476213002519 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 476213002520 hypothetical protein; Provisional; Region: PRK10259 476213002521 hypothetical protein; Provisional; Region: PRK11019 476213002522 putative mechanosensitive channel protein; Provisional; Region: PRK11465 476213002523 Mechanosensitive ion channel; Region: MS_channel; pfam00924 476213002524 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 476213002525 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 476213002526 Walker A/P-loop; other site 476213002527 ATP binding site [chemical binding]; other site 476213002528 Q-loop/lid; other site 476213002529 ABC transporter signature motif; other site 476213002530 Walker B; other site 476213002531 D-loop; other site 476213002532 H-loop/switch region; other site 476213002533 glutamine ABC transporter permease protein; Reviewed; Region: glnP; PRK09494 476213002534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213002535 dimer interface [polypeptide binding]; other site 476213002536 conserved gate region; other site 476213002537 putative PBP binding loops; other site 476213002538 ABC-ATPase subunit interface; other site 476213002539 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 476213002540 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 476213002541 substrate binding pocket [chemical binding]; other site 476213002542 membrane-bound complex binding site; other site 476213002543 hinge residues; other site 476213002544 Ferritin-like domain; Region: Ferritin; pfam00210 476213002545 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 476213002546 dimerization interface [polypeptide binding]; other site 476213002547 DPS ferroxidase diiron center [ion binding]; other site 476213002548 ion pore; other site 476213002549 threonine and homoserine efflux system; Provisional; Region: PRK10532 476213002550 EamA-like transporter family; Region: EamA; pfam00892 476213002551 outer membrane protein X; Provisional; Region: ompX; PRK09408 476213002552 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 476213002553 Sulfatase; Region: Sulfatase; pfam00884 476213002554 manganese transport regulator MntR; Provisional; Region: PRK11050 476213002555 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 476213002556 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 476213002557 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 476213002558 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 476213002559 transmembrane helices; other site 476213002560 L,D-transpeptidase; Provisional; Region: PRK10260 476213002561 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 476213002562 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 476213002563 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 476213002564 ABC transporter; Region: ABC_tran_2; pfam12848 476213002565 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 476213002566 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 476213002567 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 476213002568 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 476213002569 active site 476213002570 motif I; other site 476213002571 motif II; other site 476213002572 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 476213002573 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 476213002574 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 476213002575 dimer interface [polypeptide binding]; other site 476213002576 active site 476213002577 glycine loop; other site 476213002578 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 476213002579 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 476213002580 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 476213002581 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 476213002582 ATP binding site [chemical binding]; other site 476213002583 substrate interface [chemical binding]; other site 476213002584 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 476213002585 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 476213002586 dimer interface [polypeptide binding]; other site 476213002587 putative functional site; other site 476213002588 putative MPT binding site; other site 476213002589 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 476213002590 catalytic nucleophile [active] 476213002591 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 476213002592 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 476213002593 Walker A/P-loop; other site 476213002594 ATP binding site [chemical binding]; other site 476213002595 Q-loop/lid; other site 476213002596 ABC transporter signature motif; other site 476213002597 Walker B; other site 476213002598 D-loop; other site 476213002599 H-loop/switch region; other site 476213002600 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 476213002601 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 476213002602 Walker A/P-loop; other site 476213002603 ATP binding site [chemical binding]; other site 476213002604 Q-loop/lid; other site 476213002605 ABC transporter signature motif; other site 476213002606 Walker B; other site 476213002607 D-loop; other site 476213002608 H-loop/switch region; other site 476213002609 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 476213002610 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 476213002611 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 476213002612 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 476213002613 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213002614 dimer interface [polypeptide binding]; other site 476213002615 conserved gate region; other site 476213002616 putative PBP binding loops; other site 476213002617 ABC-ATPase subunit interface; other site 476213002618 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 476213002619 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 476213002620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213002621 dimer interface [polypeptide binding]; other site 476213002622 conserved gate region; other site 476213002623 putative PBP binding loops; other site 476213002624 ABC-ATPase subunit interface; other site 476213002625 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 476213002626 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 476213002627 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 476213002628 FeS/SAM binding site; other site 476213002629 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 476213002630 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 476213002631 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 476213002632 Ligand binding site [chemical binding]; other site 476213002633 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 476213002634 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 476213002635 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 476213002636 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 476213002637 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 476213002638 active site 476213002639 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 476213002640 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 476213002641 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 476213002642 Transcriptional regulator [Transcription]; Region: LysR; COG0583 476213002643 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213002644 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 476213002645 putative dimerization interface [polypeptide binding]; other site 476213002646 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 476213002647 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 476213002648 putative C-terminal domain interface [polypeptide binding]; other site 476213002649 putative GSH binding site (G-site) [chemical binding]; other site 476213002650 putative dimer interface [polypeptide binding]; other site 476213002651 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 476213002652 N-terminal domain interface [polypeptide binding]; other site 476213002653 dimer interface [polypeptide binding]; other site 476213002654 substrate binding pocket (H-site) [chemical binding]; other site 476213002655 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 476213002656 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 476213002657 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 476213002658 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 476213002659 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 476213002660 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 476213002661 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 476213002662 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 476213002663 active site 476213002664 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 476213002665 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213002666 putative substrate translocation pore; other site 476213002667 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 476213002668 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 476213002669 active site 476213002670 motif I; other site 476213002671 motif II; other site 476213002672 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 476213002673 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 476213002674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213002675 putative substrate translocation pore; other site 476213002676 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 476213002677 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 476213002678 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 476213002679 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 476213002680 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 476213002681 active site 476213002682 DNA binding site [nucleotide binding] 476213002683 Int/Topo IB signature motif; other site 476213002684 AIPR protein; Region: AIPR; pfam10592 476213002685 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 476213002686 Protein of unknown function (DUF2724); Region: DUF2724; pfam10893 476213002687 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 476213002688 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 476213002689 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 476213002690 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 476213002691 Phage portal protein; Region: Phage_portal; cl19194 476213002692 terminase ATPase subunit; Provisional; Region: P; PHA02535 476213002693 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 476213002694 Phage Terminase; Region: Terminase_1; cl19862 476213002695 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 476213002696 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 476213002697 Phage small terminase subunit; Region: Phage_term_smal; cl19614 476213002698 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 476213002699 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 476213002700 Protein of unknown function (DUF2586); Region: DUF2586; pfam10758 476213002701 Protein of unknown function (DUF2597); Region: DUF2597; pfam10772 476213002702 Phage holin family 2; Region: Phage_holin_2; pfam04550 476213002703 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 476213002704 Protein of unknown function (DUF2765); Region: DUF2765; pfam10963 476213002705 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 476213002706 Protein of unknown function (DUF2590); Region: DUF2590; pfam10761 476213002707 Baseplate J-like protein; Region: Baseplate_J; cl01294 476213002708 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 476213002709 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 476213002710 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 476213002711 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 476213002712 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 476213002713 baseplate hub subunit and tail lysozyme; Provisional; Region: 5; PHA02596 476213002714 putative transporter; Provisional; Region: PRK04972 476213002715 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 476213002716 TrkA-C domain; Region: TrkA_C; pfam02080 476213002717 TrkA-C domain; Region: TrkA_C; pfam02080 476213002718 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 476213002719 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 476213002720 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 476213002721 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 476213002722 dimer interface [polypeptide binding]; other site 476213002723 FMN binding site [chemical binding]; other site 476213002724 NADPH bind site [chemical binding]; other site 476213002725 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 476213002726 RimK-like ATP-grasp domain; Region: RimK; pfam08443 476213002727 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 476213002728 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 476213002729 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 476213002730 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 476213002731 Walker A/P-loop; other site 476213002732 ATP binding site [chemical binding]; other site 476213002733 Q-loop/lid; other site 476213002734 ABC transporter signature motif; other site 476213002735 Walker B; other site 476213002736 D-loop; other site 476213002737 H-loop/switch region; other site 476213002738 TOBE domain; Region: TOBE_2; pfam08402 476213002739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213002740 dimer interface [polypeptide binding]; other site 476213002741 conserved gate region; other site 476213002742 putative PBP binding loops; other site 476213002743 ABC-ATPase subunit interface; other site 476213002744 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 476213002745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213002746 dimer interface [polypeptide binding]; other site 476213002747 conserved gate region; other site 476213002748 putative PBP binding loops; other site 476213002749 ABC-ATPase subunit interface; other site 476213002750 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 476213002751 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 476213002752 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 476213002753 S-adenosylmethionine binding site [chemical binding]; other site 476213002754 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 476213002755 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 476213002756 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 476213002757 Sulfatase; Region: Sulfatase; cl19157 476213002758 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 476213002759 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 476213002760 substrate binding pocket [chemical binding]; other site 476213002761 membrane-bound complex binding site; other site 476213002762 hinge residues; other site 476213002763 arginine transporter permease subunit ArtM; Provisional; Region: artM; PRK11122 476213002764 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213002765 dimer interface [polypeptide binding]; other site 476213002766 conserved gate region; other site 476213002767 putative PBP binding loops; other site 476213002768 ABC-ATPase subunit interface; other site 476213002769 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 476213002770 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213002771 dimer interface [polypeptide binding]; other site 476213002772 conserved gate region; other site 476213002773 putative PBP binding loops; other site 476213002774 ABC-ATPase subunit interface; other site 476213002775 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 476213002776 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 476213002777 substrate binding pocket [chemical binding]; other site 476213002778 membrane-bound complex binding site; other site 476213002779 hinge residues; other site 476213002780 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 476213002781 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 476213002782 Walker A/P-loop; other site 476213002783 ATP binding site [chemical binding]; other site 476213002784 Q-loop/lid; other site 476213002785 ABC transporter signature motif; other site 476213002786 Walker B; other site 476213002787 D-loop; other site 476213002788 H-loop/switch region; other site 476213002789 putative lipoprotein; Provisional; Region: PRK10533 476213002790 hypothetical protein; Provisional; Region: PRK02877 476213002791 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 476213002792 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 476213002793 amidase catalytic site [active] 476213002794 Zn binding residues [ion binding]; other site 476213002795 substrate binding site [chemical binding]; other site 476213002796 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 476213002797 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 476213002798 NAD(P) binding site [chemical binding]; other site 476213002799 active site 476213002800 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 476213002801 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 476213002802 putative NAD(P) binding site [chemical binding]; other site 476213002803 putative active site [active] 476213002804 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 476213002805 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 476213002806 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 476213002807 tetramer interface [polypeptide binding]; other site 476213002808 pyridoxal 5'-phosphate binding site [chemical binding]; other site 476213002809 catalytic residue [active] 476213002810 pyruvate dehydrogenase; Provisional; Region: PRK09124 476213002811 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 476213002812 PYR/PP interface [polypeptide binding]; other site 476213002813 dimer interface [polypeptide binding]; other site 476213002814 tetramer interface [polypeptide binding]; other site 476213002815 TPP binding site [chemical binding]; other site 476213002816 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 476213002817 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 476213002818 TPP-binding site [chemical binding]; other site 476213002819 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 476213002820 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 476213002821 FAD binding pocket [chemical binding]; other site 476213002822 FAD binding motif [chemical binding]; other site 476213002823 phosphate binding motif [ion binding]; other site 476213002824 beta-alpha-beta structure motif; other site 476213002825 NAD binding pocket [chemical binding]; other site 476213002826 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 476213002827 catalytic loop [active] 476213002828 iron binding site [ion binding]; other site 476213002829 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 476213002830 cubane metal cluster [ion binding]; other site 476213002831 hybrid metal cluster; other site 476213002832 Predicted membrane protein [Function unknown]; Region: COG2431 476213002833 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 476213002834 AAA domain; Region: AAA_21; pfam13304 476213002835 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 476213002836 putative active site [active] 476213002837 putative metal-binding site [ion binding]; other site 476213002838 Protein of unknown function (DUF535); Region: DUF535; pfam04393 476213002839 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 476213002840 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 476213002841 Walker A/P-loop; other site 476213002842 ATP binding site [chemical binding]; other site 476213002843 Q-loop/lid; other site 476213002844 ABC transporter signature motif; other site 476213002845 Walker B; other site 476213002846 D-loop; other site 476213002847 H-loop/switch region; other site 476213002848 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 476213002849 FtsX-like permease family; Region: FtsX; pfam02687 476213002850 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 476213002851 DNA-binding site [nucleotide binding]; DNA binding site 476213002852 RNA-binding motif; other site 476213002853 Uncharacterized conserved protein [Function unknown]; Region: COG2127 476213002854 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 476213002855 Clp amino terminal domain; Region: Clp_N; pfam02861 476213002856 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 476213002857 Walker A motif; other site 476213002858 ATP binding site [chemical binding]; other site 476213002859 Walker B motif; other site 476213002860 arginine finger; other site 476213002861 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 476213002862 Walker A motif; other site 476213002863 ATP binding site [chemical binding]; other site 476213002864 Walker B motif; other site 476213002865 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 476213002866 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 476213002867 DNA binding site [nucleotide binding] 476213002868 active site 476213002869 Int/Topo IB signature motif; other site 476213002870 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 476213002871 catalytic triad [active] 476213002872 dimer interface [polypeptide binding]; other site 476213002873 conserved cis-peptide bond; other site 476213002874 Pirin-related protein [General function prediction only]; Region: COG1741 476213002875 Pirin; Region: Pirin; pfam02678 476213002876 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 476213002877 LysR family transcriptional regulator; Provisional; Region: PRK14997 476213002878 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213002879 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 476213002880 putative effector binding pocket; other site 476213002881 putative dimerization interface [polypeptide binding]; other site 476213002882 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 476213002883 rRNA binding site [nucleotide binding]; other site 476213002884 predicted 30S ribosome binding site; other site 476213002885 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 476213002886 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 476213002887 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 476213002888 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 476213002889 Walker A/P-loop; other site 476213002890 ATP binding site [chemical binding]; other site 476213002891 Q-loop/lid; other site 476213002892 ABC transporter signature motif; other site 476213002893 Walker B; other site 476213002894 D-loop; other site 476213002895 H-loop/switch region; other site 476213002896 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 476213002897 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 476213002898 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 476213002899 Walker A/P-loop; other site 476213002900 ATP binding site [chemical binding]; other site 476213002901 Q-loop/lid; other site 476213002902 ABC transporter signature motif; other site 476213002903 Walker B; other site 476213002904 D-loop; other site 476213002905 H-loop/switch region; other site 476213002906 thioredoxin reductase; Provisional; Region: PRK10262 476213002907 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 476213002908 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 476213002909 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 476213002910 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 476213002911 putative DNA binding site [nucleotide binding]; other site 476213002912 putative Zn2+ binding site [ion binding]; other site 476213002913 AsnC family; Region: AsnC_trans_reg; pfam01037 476213002914 DNA translocase FtsK; Provisional; Region: PRK10263 476213002915 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213002916 variable surface protein Vir28; Provisional; Region: PTZ00249 476213002917 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 476213002918 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 476213002919 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 476213002920 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl19192 476213002921 recombination factor protein RarA; Reviewed; Region: PRK13342 476213002922 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 476213002923 Walker A motif; other site 476213002924 ATP binding site [chemical binding]; other site 476213002925 Walker B motif; other site 476213002926 arginine finger; other site 476213002927 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 476213002928 seryl-tRNA synthetase; Provisional; Region: PRK05431 476213002929 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 476213002930 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 476213002931 dimer interface [polypeptide binding]; other site 476213002932 active site 476213002933 motif 1; other site 476213002934 motif 2; other site 476213002935 motif 3; other site 476213002936 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 476213002937 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 476213002938 putative [Fe4-S4] binding site [ion binding]; other site 476213002939 putative molybdopterin cofactor binding site [chemical binding]; other site 476213002940 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 476213002941 putative molybdopterin cofactor binding site; other site 476213002942 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 476213002943 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 476213002944 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 476213002945 putative MFS family transporter protein; Provisional; Region: PRK03633 476213002946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213002947 putative substrate translocation pore; other site 476213002948 inner membrane transporter YjeM; Provisional; Region: PRK15238 476213002949 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 476213002950 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 476213002951 FeS/SAM binding site; other site 476213002952 pathogenicity island 1 protein SopD2; Provisional; Region: PRK15380 476213002953 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 476213002954 Pyruvate formate lyase 1; Region: PFL1; cd01678 476213002955 coenzyme A binding site [chemical binding]; other site 476213002956 active site 476213002957 catalytic residues [active] 476213002958 glycine loop; other site 476213002959 formate transporter; Provisional; Region: PRK10805 476213002960 uncharacterized domain; Region: TIGR00702 476213002961 Predicted membrane protein [Function unknown]; Region: COG2323 476213002962 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 476213002963 homodimer interface [polypeptide binding]; other site 476213002964 substrate-cofactor binding pocket; other site 476213002965 pyridoxal 5'-phosphate binding site [chemical binding]; other site 476213002966 catalytic residue [active] 476213002967 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 476213002968 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 476213002969 putative active site [active] 476213002970 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 476213002971 cytidylate kinase; Provisional; Region: cmk; PRK00023 476213002972 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 476213002973 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 476213002974 active site 476213002975 CMP-binding site; other site 476213002976 The sites determining sugar specificity; other site 476213002977 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 476213002978 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 476213002979 RNA binding site [nucleotide binding]; other site 476213002980 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 476213002981 RNA binding site [nucleotide binding]; other site 476213002982 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 476213002983 RNA binding site [nucleotide binding]; other site 476213002984 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 476213002985 RNA binding site [nucleotide binding]; other site 476213002986 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 476213002987 RNA binding site [nucleotide binding]; other site 476213002988 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 476213002989 RNA binding site [nucleotide binding]; other site 476213002990 Beta subunit of integration host factor (IHFB); Region: IHF_B; cd13836 476213002991 dimer interface [polypeptide binding]; other site 476213002992 DNA binding site [nucleotide binding] 476213002993 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 476213002994 Helix-turn-helix domain; Region: HTH_28; pfam13518 476213002995 Integrase core domain; Region: rve; pfam00665 476213002996 Integrase core domain; Region: rve_3; pfam13683 476213002997 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 476213002998 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 476213002999 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 476213003000 Walker A/P-loop; other site 476213003001 ATP binding site [chemical binding]; other site 476213003002 Q-loop/lid; other site 476213003003 ABC transporter signature motif; other site 476213003004 Walker B; other site 476213003005 D-loop; other site 476213003006 H-loop/switch region; other site 476213003007 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 476213003008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 476213003009 hypothetical protein; Provisional; Region: PRK11827 476213003010 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 476213003011 Ligand binding site; other site 476213003012 oligomer interface; other site 476213003013 hypothetical protein; Provisional; Region: PRK10593 476213003014 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 476213003015 putative active site [active] 476213003016 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 476213003017 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 476213003018 S-adenosylmethionine binding site [chemical binding]; other site 476213003019 condesin subunit F; Provisional; Region: PRK05260 476213003020 condesin subunit E; Provisional; Region: PRK05256 476213003021 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 476213003022 P-loop containing region of AAA domain; Region: AAA_29; cl17516 476213003023 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 476213003024 murein L,D-transpeptidase; Provisional; Region: PRK10594 476213003025 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 476213003026 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 476213003027 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 476213003028 Peptidase M15; Region: Peptidase_M15_3; cl01194 476213003029 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 476213003030 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 476213003031 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 476213003032 pyridoxal 5'-phosphate binding site [chemical binding]; other site 476213003033 homodimer interface [polypeptide binding]; other site 476213003034 catalytic residue [active] 476213003035 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 476213003036 trimer interface [polypeptide binding]; other site 476213003037 eyelet of channel; other site 476213003038 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 476213003039 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 476213003040 putative dimer interface [polypeptide binding]; other site 476213003041 putative anticodon binding site; other site 476213003042 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 476213003043 homodimer interface [polypeptide binding]; other site 476213003044 motif 1; other site 476213003045 motif 2; other site 476213003046 active site 476213003047 motif 3; other site 476213003048 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 476213003049 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 476213003050 putative DNA binding site [nucleotide binding]; other site 476213003051 putative Zn2+ binding site [ion binding]; other site 476213003052 AsnC family; Region: AsnC_trans_reg; pfam01037 476213003053 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 476213003054 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 476213003055 catalytic residue [active] 476213003056 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 476213003057 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 476213003058 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 476213003059 active site 476213003060 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 476213003061 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 476213003062 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 476213003063 Int/Topo IB signature motif; other site 476213003064 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 476213003065 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 476213003066 RecT family; Region: RecT; pfam03837 476213003067 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 476213003068 exonuclease VIII; Reviewed; Region: PRK09709 476213003069 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 476213003070 transcriptional repressor DicA; Reviewed; Region: PRK09706 476213003071 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 476213003072 non-specific DNA binding site [nucleotide binding]; other site 476213003073 sequence-specific DNA binding site [nucleotide binding]; other site 476213003074 salt bridge; other site 476213003075 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 476213003076 Replication protein P; Region: Phage_lambda_P; pfam06992 476213003077 DinI-like family; Region: DinI; pfam06183 476213003078 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 476213003079 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 476213003080 Antitermination protein; Region: Antiterm; pfam03589 476213003081 Antitermination protein; Region: Antiterm; pfam03589 476213003082 PipA protein; Region: PipA; pfam07108 476213003083 phage holin, lambda family; Region: holin_lambda; TIGR01594 476213003084 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 476213003085 catalytic residues [active] 476213003086 Bacteriophage Rz lysis protein; Region: Phage_lysis; pfam03245 476213003087 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 476213003088 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 476213003089 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 476213003090 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 476213003091 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 476213003092 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 476213003093 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 476213003094 Protein of unknown function (DUF3277); Region: DUF3277; pfam11681 476213003095 virion protein; Provisional; Region: V; PHA02564 476213003096 Mnt; Region: mnt; PHA01513 476213003097 Prophage antirepressor [Transcription]; Region: COG3617 476213003098 BRO family, N-terminal domain; Region: Bro-N; smart01040 476213003099 BRO family, N-terminal domain; Region: Bro-N; smart01040 476213003100 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 476213003101 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 476213003102 Baseplate J-like protein; Region: Baseplate_J; cl01294 476213003103 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 476213003104 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 476213003105 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 476213003106 type III secretion protein GogB; Provisional; Region: PRK15386 476213003107 GTP-binding protein LepA; Provisional; Region: PRK05433 476213003108 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 476213003109 G1 box; other site 476213003110 putative GEF interaction site [polypeptide binding]; other site 476213003111 GTP/Mg2+ binding site [chemical binding]; other site 476213003112 Switch I region; other site 476213003113 G2 box; other site 476213003114 G3 box; other site 476213003115 Switch II region; other site 476213003116 G4 box; other site 476213003117 G5 box; other site 476213003118 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 476213003119 Elongation Factor G, domain II; Region: EFG_II; pfam14492 476213003120 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 476213003121 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 476213003122 signal peptidase I; Provisional; Region: PRK10861 476213003123 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 476213003124 Catalytic site [active] 476213003125 ribonuclease III; Reviewed; Region: rnc; PRK00102 476213003126 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 476213003127 dimerization interface [polypeptide binding]; other site 476213003128 active site 476213003129 metal binding site [ion binding]; metal-binding site 476213003130 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 476213003131 dsRNA binding site [nucleotide binding]; other site 476213003132 GTPase Era; Reviewed; Region: era; PRK00089 476213003133 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 476213003134 G1 box; other site 476213003135 GTP/Mg2+ binding site [chemical binding]; other site 476213003136 Switch I region; other site 476213003137 G2 box; other site 476213003138 Switch II region; other site 476213003139 G3 box; other site 476213003140 G4 box; other site 476213003141 G5 box; other site 476213003142 KH domain; Region: KH_2; pfam07650 476213003143 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 476213003144 Recombination protein O N terminal; Region: RecO_N; pfam11967 476213003145 Recombination protein O C terminal; Region: RecO_C; pfam02565 476213003146 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 476213003147 active site 476213003148 hydrophilic channel; other site 476213003149 dimerization interface [polypeptide binding]; other site 476213003150 catalytic residues [active] 476213003151 active site lid [active] 476213003152 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 476213003153 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 476213003154 Transcriptional regulator [Transcription]; Region: LysR; COG0583 476213003155 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213003156 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 476213003157 dimerization interface [polypeptide binding]; other site 476213003158 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 476213003159 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213003160 putative substrate translocation pore; other site 476213003161 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 476213003162 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 476213003163 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 476213003164 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 476213003165 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 476213003166 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 476213003167 putative active site [active] 476213003168 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 476213003169 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 476213003170 putative active site [active] 476213003171 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 476213003172 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 476213003173 active site turn [active] 476213003174 phosphorylation site [posttranslational modification] 476213003175 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 476213003176 hypothetical protein; Provisional; Region: PRK11590 476213003177 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 476213003178 nucleoside/Zn binding site; other site 476213003179 dimer interface [polypeptide binding]; other site 476213003180 catalytic motif [active] 476213003181 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 476213003182 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 476213003183 substrate binding pocket [chemical binding]; other site 476213003184 membrane-bound complex binding site; other site 476213003185 hinge residues; other site 476213003186 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 476213003187 N-acetyl-D-glucosamine binding site [chemical binding]; other site 476213003188 catalytic residue [active] 476213003189 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 476213003190 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 476213003191 dimerization interface [polypeptide binding]; other site 476213003192 ATP binding site [chemical binding]; other site 476213003193 Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of...; Region: PurL; cd02193 476213003194 dimerization interface [polypeptide binding]; other site 476213003195 ATP binding site [chemical binding]; other site 476213003196 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 476213003197 putative active site [active] 476213003198 catalytic triad [active] 476213003199 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 476213003200 HAMP domain; Region: HAMP; pfam00672 476213003201 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 476213003202 dimer interface [polypeptide binding]; other site 476213003203 phosphorylation site [posttranslational modification] 476213003204 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 476213003205 ATP binding site [chemical binding]; other site 476213003206 Mg2+ binding site [ion binding]; other site 476213003207 G-X-G motif; other site 476213003208 hypothetical protein; Provisional; Region: PRK10722 476213003209 response regulator GlrR; Provisional; Region: PRK15115 476213003210 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 476213003211 active site 476213003212 phosphorylation site [posttranslational modification] 476213003213 intermolecular recognition site; other site 476213003214 dimerization interface [polypeptide binding]; other site 476213003215 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 476213003216 Walker A motif; other site 476213003217 ATP binding site [chemical binding]; other site 476213003218 Walker B motif; other site 476213003219 arginine finger; other site 476213003220 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 476213003221 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 476213003222 POT family; Region: PTR2; cl17359 476213003223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213003224 putative substrate translocation pore; other site 476213003225 lysine decarboxylase CadA; Provisional; Region: PRK15400 476213003226 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 476213003227 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 476213003228 homodimer interface [polypeptide binding]; other site 476213003229 pyridoxal 5'-phosphate binding site [chemical binding]; other site 476213003230 catalytic residue [active] 476213003231 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 476213003232 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 476213003233 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 476213003234 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 476213003235 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 476213003236 DNA binding site [nucleotide binding] 476213003237 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 476213003238 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 476213003239 heme-binding site [chemical binding]; other site 476213003240 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 476213003241 FAD binding pocket [chemical binding]; other site 476213003242 FAD binding motif [chemical binding]; other site 476213003243 phosphate binding motif [ion binding]; other site 476213003244 beta-alpha-beta structure motif; other site 476213003245 NAD binding pocket [chemical binding]; other site 476213003246 Heme binding pocket [chemical binding]; other site 476213003247 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 476213003248 dimer interface [polypeptide binding]; other site 476213003249 active site 476213003250 glycine-pyridoxal phosphate binding site [chemical binding]; other site 476213003251 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 476213003252 folate binding site [chemical binding]; other site 476213003253 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213003254 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 476213003255 putative substrate translocation pore; other site 476213003256 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 476213003257 PRD domain; Region: PRD; pfam00874 476213003258 PRD domain; Region: PRD; pfam00874 476213003259 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 476213003260 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 476213003261 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 476213003262 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 476213003263 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 476213003264 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 476213003265 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 476213003266 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 476213003267 FAD binding pocket [chemical binding]; other site 476213003268 FAD binding motif [chemical binding]; other site 476213003269 phosphate binding motif [ion binding]; other site 476213003270 beta-alpha-beta structure motif; other site 476213003271 NAD binding pocket [chemical binding]; other site 476213003272 Iron coordination center [ion binding]; other site 476213003273 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 476213003274 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 476213003275 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 476213003276 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 476213003277 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 476213003278 active site 476213003279 dimerization interface [polypeptide binding]; other site 476213003280 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 476213003281 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 476213003282 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 476213003283 Rrf2 family protein; Region: rrf2_super; TIGR00738 476213003284 cysteine desulfurase; Provisional; Region: PRK14012 476213003285 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 476213003286 catalytic residue [active] 476213003287 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 476213003288 trimerization site [polypeptide binding]; other site 476213003289 active site 476213003290 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 476213003291 co-chaperone HscB; Provisional; Region: hscB; PRK05014 476213003292 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 476213003293 HSP70 interaction site [polypeptide binding]; other site 476213003294 HSCB C-terminal oligomerization domain; Region: HSCB_C; pfam07743 476213003295 chaperone protein HscA; Provisional; Region: hscA; PRK05183 476213003296 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 476213003297 nucleotide binding site [chemical binding]; other site 476213003298 putative NEF/HSP70 interaction site [polypeptide binding]; other site 476213003299 SBD interface [polypeptide binding]; other site 476213003300 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 476213003301 catalytic loop [active] 476213003302 iron binding site [ion binding]; other site 476213003303 hypothetical protein; Provisional; Region: PRK10721 476213003304 aminopeptidase B; Provisional; Region: PRK05015 476213003305 Peptidase; Region: DUF3663; pfam12404 476213003306 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 476213003307 interface (dimer of trimers) [polypeptide binding]; other site 476213003308 Substrate-binding/catalytic site; other site 476213003309 Zn-binding sites [ion binding]; other site 476213003310 SseB protein N-terminal domain; Region: SseB; pfam07179 476213003311 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 476213003312 SseB protein C-terminal domain; Region: SseB_C; pfam14581 476213003313 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 476213003314 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 476213003315 active site residue [active] 476213003316 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 476213003317 active site residue [active] 476213003318 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 476213003319 MG2 domain; Region: A2M_N; pfam01835 476213003320 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 476213003321 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 476213003322 surface patch; other site 476213003323 thioester region; other site 476213003324 penicillin-binding protein 1C; Provisional; Region: PRK11240 476213003325 Transglycosylase; Region: Transgly; pfam00912 476213003326 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 476213003327 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 476213003328 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 476213003329 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 476213003330 putative [Fe4-S4] binding site [ion binding]; other site 476213003331 putative molybdopterin cofactor binding site [chemical binding]; other site 476213003332 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 476213003333 putative molybdopterin cofactor binding site; other site 476213003334 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 476213003335 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 476213003336 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 476213003337 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 476213003338 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 476213003339 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 476213003340 Nucleoside diphosphate kinase; Region: NDK; pfam00334 476213003341 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 476213003342 active site 476213003343 multimer interface [polypeptide binding]; other site 476213003344 23S rRNA m2A2503 methyltransferase; Region: TIGR00048 476213003345 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 476213003346 FeS/SAM binding site; other site 476213003347 cytoskeletal protein RodZ; Provisional; Region: PRK10856 476213003348 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 476213003349 non-specific DNA binding site [nucleotide binding]; other site 476213003350 salt bridge; other site 476213003351 sequence-specific DNA binding site [nucleotide binding]; other site 476213003352 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 476213003353 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 476213003354 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 476213003355 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 476213003356 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 476213003357 dimer interface [polypeptide binding]; other site 476213003358 motif 1; other site 476213003359 active site 476213003360 motif 2; other site 476213003361 motif 3; other site 476213003362 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 476213003363 anticodon binding site; other site 476213003364 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 476213003365 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 476213003366 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 476213003367 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 476213003368 Trp docking motif [polypeptide binding]; other site 476213003369 active site 476213003370 GTP-binding protein Der; Reviewed; Region: PRK00093 476213003371 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 476213003372 G1 box; other site 476213003373 GTP/Mg2+ binding site [chemical binding]; other site 476213003374 Switch I region; other site 476213003375 G2 box; other site 476213003376 Switch II region; other site 476213003377 G3 box; other site 476213003378 G4 box; other site 476213003379 G5 box; other site 476213003380 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 476213003381 G1 box; other site 476213003382 GTP/Mg2+ binding site [chemical binding]; other site 476213003383 Switch I region; other site 476213003384 G2 box; other site 476213003385 G3 box; other site 476213003386 Switch II region; other site 476213003387 G4 box; other site 476213003388 G5 box; other site 476213003389 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 476213003390 zinc-ribbons; Region: zinc-ribbons_6; pfam07191 476213003391 intimin-like protein SinH; Provisional; Region: PRK15318 476213003392 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 476213003393 intimin-like protein SinH; Provisional; Region: PRK15318 476213003394 outer membrane protein RatA; Provisional; Region: PRK15315 476213003395 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 476213003396 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 476213003397 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 476213003398 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 476213003399 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 476213003400 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 476213003401 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 476213003402 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 476213003403 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 476213003404 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 476213003405 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 476213003406 outer membrane protein RatB; Provisional; Region: PRK15314 476213003407 outer membrane protein RatB; Provisional; Region: PRK15314 476213003408 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 476213003409 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 476213003410 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 476213003411 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 476213003412 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 476213003413 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 476213003414 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 476213003415 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 476213003416 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 476213003417 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 476213003418 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 476213003419 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 476213003420 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 476213003421 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 476213003422 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 476213003423 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 476213003424 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 476213003425 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 476213003426 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 476213003427 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 476213003428 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 476213003429 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 476213003430 Autotransporter beta-domain; Region: Autotransporter; smart00869 476213003431 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 476213003432 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 476213003433 generic binding surface II; other site 476213003434 generic binding surface I; other site 476213003435 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 476213003436 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 476213003437 active site 476213003438 Domain in cystathionine beta-synthase and other proteins; Region: CBS; smart00116 476213003439 GMP synthase; Reviewed; Region: guaA; PRK00074 476213003440 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 476213003441 AMP/PPi binding site [chemical binding]; other site 476213003442 candidate oxyanion hole; other site 476213003443 catalytic triad [active] 476213003444 potential glutamine specificity residues [chemical binding]; other site 476213003445 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 476213003446 ATP Binding subdomain [chemical binding]; other site 476213003447 Ligand Binding sites [chemical binding]; other site 476213003448 Dimerization subdomain; other site 476213003449 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 476213003450 SEC-C motif; Region: SEC-C; pfam02810 476213003451 Integrase core domain; Region: rve; pfam00665 476213003452 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 476213003453 MASE1; Region: MASE1; pfam05231 476213003454 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 476213003455 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 476213003456 exopolyphosphatase; Provisional; Region: PRK10854 476213003457 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 476213003458 nucleotide binding site [chemical binding]; other site 476213003459 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 476213003460 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 476213003461 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 476213003462 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 476213003463 putative active site [active] 476213003464 catalytic site [active] 476213003465 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 476213003466 domain interface [polypeptide binding]; other site 476213003467 active site 476213003468 catalytic site [active] 476213003469 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 476213003470 active site 476213003471 substrate binding site [chemical binding]; other site 476213003472 cosubstrate binding site; other site 476213003473 catalytic site [active] 476213003474 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 476213003475 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 476213003476 dimerization interface [polypeptide binding]; other site 476213003477 putative ATP binding site [chemical binding]; other site 476213003478 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 476213003479 active site 476213003480 uracil transporter; Provisional; Region: PRK10720 476213003481 uracil-xanthine permease; Region: ncs2; TIGR00801 476213003482 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 476213003483 DNA replication initiation factor; Provisional; Region: PRK08084 476213003484 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 476213003485 catalytic residues [active] 476213003486 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 476213003487 Peptidase family M48; Region: Peptidase_M48; cl12018 476213003488 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 476213003489 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 476213003490 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 476213003491 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 476213003492 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 476213003493 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 476213003494 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 476213003495 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 476213003496 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 476213003497 catalytic triad [active] 476213003498 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 476213003499 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 476213003500 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 476213003501 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 476213003502 dimer interface [polypeptide binding]; other site 476213003503 active site 476213003504 catalytic residue [active] 476213003505 lipoprotein; Provisional; Region: PRK11679 476213003506 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 476213003507 ATP binding site [chemical binding]; other site 476213003508 active site 476213003509 substrate binding site [chemical binding]; other site 476213003510 Predicted metalloprotease [General function prediction only]; Region: COG2321 476213003511 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 476213003512 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 476213003513 Helicase; Region: Helicase_RecD; pfam05127 476213003514 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 476213003515 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 476213003516 hypothetical protein; Provisional; Region: PRK13664 476213003517 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 476213003518 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 476213003519 metal binding site [ion binding]; metal-binding site 476213003520 dimer interface [polypeptide binding]; other site 476213003521 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 476213003522 putative catalytic residues [active] 476213003523 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 476213003524 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 476213003525 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 476213003526 dimerization interface [polypeptide binding]; other site 476213003527 Histidine kinase; Region: HisKA_3; pfam07730 476213003528 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 476213003529 ATP binding site [chemical binding]; other site 476213003530 Mg2+ binding site [ion binding]; other site 476213003531 G-X-G motif; other site 476213003532 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 476213003533 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 476213003534 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 476213003535 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 476213003536 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 476213003537 putative periplasmic esterase; Provisional; Region: PRK03642 476213003538 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 476213003539 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 476213003540 dimer interface [polypeptide binding]; other site 476213003541 ADP-ribose binding site [chemical binding]; other site 476213003542 active site 476213003543 nudix motif; other site 476213003544 metal binding site [ion binding]; metal-binding site 476213003545 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 476213003546 transketolase; Reviewed; Region: PRK12753 476213003547 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 476213003548 TPP-binding site [chemical binding]; other site 476213003549 dimer interface [polypeptide binding]; other site 476213003550 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 476213003551 PYR/PP interface [polypeptide binding]; other site 476213003552 dimer interface [polypeptide binding]; other site 476213003553 TPP binding site [chemical binding]; other site 476213003554 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 476213003555 transaldolase-like protein; Provisional; Region: PTZ00411 476213003556 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 476213003557 active site 476213003558 dimer interface [polypeptide binding]; other site 476213003559 catalytic residue [active] 476213003560 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 476213003561 Malic enzyme, N-terminal domain; Region: malic; pfam00390 476213003562 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 476213003563 putative NAD(P) binding site [chemical binding]; other site 476213003564 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 476213003565 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 476213003566 putative hexamer interface [polypeptide binding]; other site 476213003567 putative hexagonal pore; other site 476213003568 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 476213003569 G1 box; other site 476213003570 GTP/Mg2+ binding site [chemical binding]; other site 476213003571 G2 box; other site 476213003572 Switch I region; other site 476213003573 G3 box; other site 476213003574 Switch II region; other site 476213003575 G4 box; other site 476213003576 G5 box; other site 476213003577 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 476213003578 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 476213003579 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 476213003580 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 476213003581 putative catalytic cysteine [active] 476213003582 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 476213003583 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 476213003584 nucleotide binding site [chemical binding]; other site 476213003585 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 476213003586 nucleotide binding site [chemical binding]; other site 476213003587 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 476213003588 active site 476213003589 metal binding site [ion binding]; metal-binding site 476213003590 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 476213003591 Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition [Amino acid transport and metabolism]; Region: EutA; COG4819 476213003592 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 476213003593 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 476213003594 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 476213003595 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 476213003596 Hexamer interface [polypeptide binding]; other site 476213003597 Hexagonal pore residue; other site 476213003598 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 476213003599 putative hexamer interface [polypeptide binding]; other site 476213003600 putative hexagonal pore; other site 476213003601 carboxysome structural protein EutK; Provisional; Region: PRK15466 476213003602 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 476213003603 Hexamer interface [polypeptide binding]; other site 476213003604 Hexagonal pore residue; other site 476213003605 transcriptional regulator EutR; Provisional; Region: PRK10130 476213003606 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213003607 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 476213003608 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 476213003609 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 476213003610 active site 476213003611 metal binding site [ion binding]; metal-binding site 476213003612 putative acetyltransferase; Provisional; Region: PRK03624 476213003613 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 476213003614 Coenzyme A binding pocket [chemical binding]; other site 476213003615 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 476213003616 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 476213003617 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 476213003618 short chain dehydrogenase; Provisional; Region: PRK08226 476213003619 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 476213003620 NAD binding site [chemical binding]; other site 476213003621 homotetramer interface [polypeptide binding]; other site 476213003622 homodimer interface [polypeptide binding]; other site 476213003623 active site 476213003624 thiosulfate transporter subunit; Provisional; Region: PRK10852 476213003625 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 476213003626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213003627 dimer interface [polypeptide binding]; other site 476213003628 conserved gate region; other site 476213003629 putative PBP binding loops; other site 476213003630 ABC-ATPase subunit interface; other site 476213003631 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 476213003632 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213003633 dimer interface [polypeptide binding]; other site 476213003634 conserved gate region; other site 476213003635 putative PBP binding loops; other site 476213003636 ABC-ATPase subunit interface; other site 476213003637 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 476213003638 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 476213003639 Walker A/P-loop; other site 476213003640 ATP binding site [chemical binding]; other site 476213003641 Q-loop/lid; other site 476213003642 ABC transporter signature motif; other site 476213003643 Walker B; other site 476213003644 D-loop; other site 476213003645 H-loop/switch region; other site 476213003646 TOBE-like domain; Region: TOBE_3; pfam12857 476213003647 cysteine synthase; Region: PLN02565 476213003648 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 476213003649 dimer interface [polypeptide binding]; other site 476213003650 pyridoxal 5'-phosphate binding site [chemical binding]; other site 476213003651 catalytic residue [active] 476213003652 Transglycosylase; Region: Transgly; pfam00912 476213003653 hypothetical protein; Provisional; Region: PRK10318 476213003654 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 476213003655 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 476213003656 catalytic triad [active] 476213003657 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 476213003658 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 476213003659 DNA-binding site [nucleotide binding]; DNA binding site 476213003660 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 476213003661 pyridoxal 5'-phosphate binding site [chemical binding]; other site 476213003662 homodimer interface [polypeptide binding]; other site 476213003663 catalytic residue [active] 476213003664 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 476213003665 dimer interface [polypeptide binding]; other site 476213003666 pyridoxal binding site [chemical binding]; other site 476213003667 ATP binding site [chemical binding]; other site 476213003668 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 476213003669 HPr interaction site; other site 476213003670 glycerol kinase (GK) interaction site [polypeptide binding]; other site 476213003671 active site 476213003672 phosphorylation site [posttranslational modification] 476213003673 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 476213003674 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 476213003675 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 476213003676 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 476213003677 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 476213003678 dimerization domain swap beta strand [polypeptide binding]; other site 476213003679 regulatory protein interface [polypeptide binding]; other site 476213003680 active site 476213003681 regulatory phosphorylation site [posttranslational modification]; other site 476213003682 cysteine synthase; Region: PLN02565 476213003683 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 476213003684 dimer interface [polypeptide binding]; other site 476213003685 pyridoxal 5'-phosphate binding site [chemical binding]; other site 476213003686 catalytic residue [active] 476213003687 putative sulfate transport protein CysZ; Validated; Region: PRK04949 476213003688 cell division protein ZipA; Provisional; Region: PRK03427 476213003689 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 476213003690 FtsZ protein binding site [polypeptide binding]; other site 476213003691 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 476213003692 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 476213003693 nucleotide binding pocket [chemical binding]; other site 476213003694 K-X-D-G motif; other site 476213003695 catalytic site [active] 476213003696 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 476213003697 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 476213003698 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 476213003699 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 476213003700 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 476213003701 Dimer interface [polypeptide binding]; other site 476213003702 BRCT sequence motif; other site 476213003703 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 476213003704 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 476213003705 Transcriptional regulator [Transcription]; Region: LysR; COG0583 476213003706 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213003707 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 476213003708 putative dimerization interface [polypeptide binding]; other site 476213003709 hypothetical protein; Provisional; Region: PRK11528 476213003710 purine nucleoside phosphorylase; Provisional; Region: PRK08202 476213003711 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 476213003712 nucleoside transporter; Region: 2A0110; TIGR00889 476213003713 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 476213003714 XapX domain; Region: XapX; TIGR03510 476213003715 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 476213003716 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213003717 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 476213003718 putative dimerization interface [polypeptide binding]; other site 476213003719 putative substrate binding pocket [chemical binding]; other site 476213003720 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 476213003721 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 476213003722 active site 476213003723 HIGH motif; other site 476213003724 KMSKS motif; other site 476213003725 Protein of unknown function (DUF3150); Region: DUF3150; pfam11348 476213003726 Winged helix-turn helix; Region: HTH_29; pfam13551 476213003727 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 476213003728 salt bridge; other site 476213003729 non-specific DNA binding site [nucleotide binding]; other site 476213003730 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 476213003731 sequence-specific DNA binding site [nucleotide binding]; other site 476213003732 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 476213003733 MASE1; Region: MASE1; pfam05231 476213003734 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 476213003735 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 476213003736 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 476213003737 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 476213003738 Nucleoside recognition; Region: Gate; pfam07670 476213003739 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 476213003740 manganese transport protein MntH; Reviewed; Region: PRK00701 476213003741 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 476213003742 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 476213003743 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 476213003744 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 476213003745 active site 476213003746 catalytic tetrad [active] 476213003747 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 476213003748 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 476213003749 dimer interface [polypeptide binding]; other site 476213003750 PYR/PP interface [polypeptide binding]; other site 476213003751 TPP binding site [chemical binding]; other site 476213003752 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 476213003753 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 476213003754 TPP-binding site [chemical binding]; other site 476213003755 dimer interface [polypeptide binding]; other site 476213003756 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 476213003757 Cl- selectivity filter; other site 476213003758 Cl- binding residues [ion binding]; other site 476213003759 pore gating glutamate residue; other site 476213003760 dimer interface [polypeptide binding]; other site 476213003761 glucokinase; Provisional; Region: glk; PRK00292 476213003762 aminotransferase; Validated; Region: PRK08175 476213003763 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 476213003764 pyridoxal 5'-phosphate binding site [chemical binding]; other site 476213003765 homodimer interface [polypeptide binding]; other site 476213003766 catalytic residue [active] 476213003767 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 476213003768 Helix-turn-helix domain; Region: HTH_28; pfam13518 476213003769 Integrase core domain; Region: rve; pfam00665 476213003770 Integrase core domain; Region: rve_3; pfam13683 476213003771 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 476213003772 putative acyl-acceptor binding pocket; other site 476213003773 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 476213003774 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 476213003775 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213003776 putative substrate translocation pore; other site 476213003777 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 476213003778 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 476213003779 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 476213003780 dimerization interface [polypeptide binding]; other site 476213003781 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 476213003782 dimer interface [polypeptide binding]; other site 476213003783 phosphorylation site [posttranslational modification] 476213003784 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 476213003785 ATP binding site [chemical binding]; other site 476213003786 Mg2+ binding site [ion binding]; other site 476213003787 G-X-G motif; other site 476213003788 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 476213003789 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 476213003790 active site 476213003791 phosphorylation site [posttranslational modification] 476213003792 intermolecular recognition site; other site 476213003793 dimerization interface [polypeptide binding]; other site 476213003794 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 476213003795 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 476213003796 Outer membrane protease [Cell envelope biogenesis, outer membrane]; Region: OmpT; COG4571 476213003797 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 476213003798 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 476213003799 Protein of unknown function (DUF2856); Region: DUF2856; pfam11043 476213003800 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 476213003801 active site 476213003802 catalytic site [active] 476213003803 substrate binding site [chemical binding]; other site 476213003804 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 476213003805 dimer interface [polypeptide binding]; other site 476213003806 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 476213003807 ssDNA binding site [nucleotide binding]; other site 476213003808 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 476213003809 Lambda Phage CIII; Region: Lambda_CIII; pfam02061 476213003810 hypothetical protein; Region: PHA01516 476213003811 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 476213003812 non-specific DNA binding site [nucleotide binding]; other site 476213003813 salt bridge; other site 476213003814 sequence-specific DNA binding site [nucleotide binding]; other site 476213003815 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 476213003816 active site 476213003817 metal binding site [ion binding]; metal-binding site 476213003818 interdomain interaction site; other site 476213003819 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 476213003820 Walker A motif; other site 476213003821 ATP binding site [chemical binding]; other site 476213003822 Walker B motif; other site 476213003823 NinF protein; Region: NinF; pfam05810 476213003824 endodeoxyribonuclease RUS; Reviewed; Region: PRK09786 476213003825 Phage NinH protein; Region: Phage_NinH; pfam06322 476213003826 phage holin, lambda family; Region: holin_lambda; TIGR01594 476213003827 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 476213003828 N-acetyl-D-glucosamine binding site [chemical binding]; other site 476213003829 catalytic residue [active] 476213003830 Protein of unknown function (DUF2422); Region: DUF2422; pfam10337 476213003831 Bacteriophage Rz lysis protein; Region: Phage_lysis; pfam03245 476213003832 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 476213003833 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 476213003834 Protein of unknown function (DUF2560); Region: DUF2560; pfam10834 476213003835 Phage terminase large subunit; Region: Terminase_3; cl12054 476213003836 TolA protein; Region: tolA_full; TIGR02794 476213003837 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 476213003838 Bacteriophage, scaffolding protein; Region: Phage-scaffold; pfam09306 476213003839 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 476213003840 Phage stabilisation protein; Region: Phage_stabilize; pfam11134 476213003841 Protein of unknown function (DUF2824); Region: DUF2824; pfam11039 476213003842 Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241; Region: DM14; smart00685 476213003843 Mnt; Region: mnt; PHA01513 476213003844 Arc-like DNA binding domain; Region: Arc; pfam03869 476213003845 Regulatory protein Mnt; Region: Repressor_Mnt; pfam11423 476213003846 Head binding; Region: Head_binding; pfam09008 476213003847 Right handed beta helix region; Region: Beta_helix; pfam13229 476213003848 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 476213003849 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 476213003850 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 476213003851 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 476213003852 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 476213003853 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 476213003854 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 476213003855 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 476213003856 dimer interface [polypeptide binding]; other site 476213003857 active site 476213003858 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 476213003859 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 476213003860 substrate binding site [chemical binding]; other site 476213003861 oxyanion hole (OAH) forming residues; other site 476213003862 trimer interface [polypeptide binding]; other site 476213003863 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 476213003864 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 476213003865 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 476213003866 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 476213003867 catalytic core [active] 476213003868 hypothetical protein; Provisional; Region: PRK04946 476213003869 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 476213003870 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK11805 476213003871 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 476213003872 S-adenosylmethionine binding site [chemical binding]; other site 476213003873 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 476213003874 Tetramer interface [polypeptide binding]; other site 476213003875 active site 476213003876 FMN-binding site [chemical binding]; other site 476213003877 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 476213003878 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 476213003879 hypothetical protein; Provisional; Region: PRK10621 476213003880 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 476213003881 YfcL protein; Region: YfcL; pfam08891 476213003882 Uncharacterized conserved protein [Function unknown]; Region: COG4121 476213003883 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 476213003884 tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197 476213003885 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 476213003886 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 476213003887 dimer interface [polypeptide binding]; other site 476213003888 active site 476213003889 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 476213003890 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 476213003891 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 476213003892 non-specific DNA binding site [nucleotide binding]; other site 476213003893 salt bridge; other site 476213003894 sequence-specific DNA binding site [nucleotide binding]; other site 476213003895 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 476213003896 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 476213003897 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 476213003898 ligand binding site [chemical binding]; other site 476213003899 NAD binding site [chemical binding]; other site 476213003900 catalytic site [active] 476213003901 homodimer interface [polypeptide binding]; other site 476213003902 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 476213003903 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 476213003904 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 476213003905 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 476213003906 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 476213003907 dimerization interface 3.5A [polypeptide binding]; other site 476213003908 active site 476213003909 hypothetical protein; Provisional; Region: PRK10847 476213003910 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 476213003911 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 476213003912 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 476213003913 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 476213003914 cell division protein DedD; Provisional; Region: PRK11633 476213003915 Sporulation related domain; Region: SPOR; pfam05036 476213003916 colicin V production protein; Provisional; Region: PRK10845 476213003917 amidophosphoribosyltransferase; Provisional; Region: PRK09246 476213003918 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 476213003919 active site 476213003920 tetramer interface [polypeptide binding]; other site 476213003921 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 476213003922 active site 476213003923 PAS fold; Region: PAS_4; pfam08448 476213003924 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 476213003925 putative active site [active] 476213003926 heme pocket [chemical binding]; other site 476213003927 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 476213003928 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 476213003929 Walker A motif; other site 476213003930 ATP binding site [chemical binding]; other site 476213003931 Walker B motif; other site 476213003932 arginine finger; other site 476213003933 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 476213003934 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 476213003935 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 476213003936 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 476213003937 catalytic residue [active] 476213003938 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 476213003939 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 476213003940 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 476213003941 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 476213003942 dimer interface [polypeptide binding]; other site 476213003943 active site 476213003944 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 476213003945 substrate binding site [chemical binding]; other site 476213003946 catalytic residue [active] 476213003947 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 476213003948 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 476213003949 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 476213003950 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 476213003951 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 476213003952 substrate binding pocket [chemical binding]; other site 476213003953 membrane-bound complex binding site; other site 476213003954 hinge residues; other site 476213003955 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 476213003956 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 476213003957 substrate binding pocket [chemical binding]; other site 476213003958 membrane-bound complex binding site; other site 476213003959 hinge residues; other site 476213003960 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 476213003961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213003962 dimer interface [polypeptide binding]; other site 476213003963 conserved gate region; other site 476213003964 putative PBP binding loops; other site 476213003965 ABC-ATPase subunit interface; other site 476213003966 ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism]; Region: ArtM; COG4160 476213003967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213003968 dimer interface [polypeptide binding]; other site 476213003969 conserved gate region; other site 476213003970 putative PBP binding loops; other site 476213003971 ABC-ATPase subunit interface; other site 476213003972 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 476213003973 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 476213003974 Walker A/P-loop; other site 476213003975 ATP binding site [chemical binding]; other site 476213003976 Q-loop/lid; other site 476213003977 ABC transporter signature motif; other site 476213003978 Walker B; other site 476213003979 D-loop; other site 476213003980 H-loop/switch region; other site 476213003981 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 476213003982 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 476213003983 putative NAD(P) binding site [chemical binding]; other site 476213003984 putative active site [active] 476213003985 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 476213003986 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 476213003987 C-terminal domain interface [polypeptide binding]; other site 476213003988 GSH binding site (G-site) [chemical binding]; other site 476213003989 dimer interface [polypeptide binding]; other site 476213003990 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 476213003991 N-terminal domain interface [polypeptide binding]; other site 476213003992 putative dimer interface [polypeptide binding]; other site 476213003993 active site 476213003994 glutathione S-transferase; Provisional; Region: PRK15113 476213003995 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 476213003996 C-terminal domain interface [polypeptide binding]; other site 476213003997 GSH binding site (G-site) [chemical binding]; other site 476213003998 dimer interface [polypeptide binding]; other site 476213003999 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 476213004000 N-terminal domain interface [polypeptide binding]; other site 476213004001 putative dimer interface [polypeptide binding]; other site 476213004002 putative substrate binding pocket (H-site) [chemical binding]; other site 476213004003 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 476213004004 active site 476213004005 metal binding site [ion binding]; metal-binding site 476213004006 homotetramer interface [polypeptide binding]; other site 476213004007 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 476213004008 nudix motif; other site 476213004009 Transcriptional regulators [Transcription]; Region: PurR; COG1609 476213004010 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 476213004011 DNA binding site [nucleotide binding] 476213004012 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 476213004013 putative dimerization interface [polypeptide binding]; other site 476213004014 putative ligand binding site [chemical binding]; other site 476213004015 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 476213004016 active site 476213004017 phosphorylation site [posttranslational modification] 476213004018 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 476213004019 active site 476213004020 P-loop; other site 476213004021 phosphorylation site [posttranslational modification] 476213004022 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK12996 476213004023 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 476213004024 TPP-binding site [chemical binding]; other site 476213004025 dimer interface [polypeptide binding]; other site 476213004026 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 476213004027 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 476213004028 PYR/PP interface [polypeptide binding]; other site 476213004029 dimer interface [polypeptide binding]; other site 476213004030 TPP binding site [chemical binding]; other site 476213004031 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 476213004032 hypothetical protein; Provisional; Region: PRK11588 476213004033 phosphate acetyltransferase; Reviewed; Region: PRK05632 476213004034 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 476213004035 DRTGG domain; Region: DRTGG; pfam07085 476213004036 phosphate acetyltransferase; Region: pta; TIGR00651 476213004037 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 476213004038 hypothetical protein; Provisional; Region: PRK01816 476213004039 hypothetical protein; Validated; Region: PRK05445 476213004040 putative phosphatase; Provisional; Region: PRK11587 476213004041 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 476213004042 active site 476213004043 motif I; other site 476213004044 motif II; other site 476213004045 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 476213004046 transmembrane helices; other site 476213004047 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 476213004048 TrkA-C domain; Region: TrkA_C; pfam02080 476213004049 TrkA-C domain; Region: TrkA_C; pfam02080 476213004050 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 476213004051 5'-nucleotidase; Provisional; Region: PRK03826 476213004052 aminotransferase AlaT; Validated; Region: PRK09265 476213004053 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 476213004054 pyridoxal 5'-phosphate binding site [chemical binding]; other site 476213004055 homodimer interface [polypeptide binding]; other site 476213004056 catalytic residue [active] 476213004057 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 476213004058 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213004059 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 476213004060 putative dimerization interface [polypeptide binding]; other site 476213004061 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 476213004062 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 476213004063 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852 476213004064 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 476213004065 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl19174 476213004066 NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905 476213004067 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 476213004068 putative dimer interface [polypeptide binding]; other site 476213004069 [2Fe-2S] cluster binding site [ion binding]; other site 476213004070 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 476213004071 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 476213004072 SLBB domain; Region: SLBB; pfam10531 476213004073 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 476213004074 NADH dehydrogenase subunit G; Validated; Region: PRK08166 476213004075 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 476213004076 catalytic loop [active] 476213004077 iron binding site [ion binding]; other site 476213004078 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 476213004079 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 476213004080 [4Fe-4S] binding site [ion binding]; other site 476213004081 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 476213004082 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 476213004083 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 476213004084 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 476213004085 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 476213004086 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 476213004087 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 476213004088 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 476213004089 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 476213004090 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 476213004091 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 476213004092 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 476213004093 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 476213004094 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 476213004095 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 476213004096 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 476213004097 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 476213004098 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 476213004099 active site 476213004100 phosphorylation site [posttranslational modification] 476213004101 intermolecular recognition site; other site 476213004102 dimerization interface [polypeptide binding]; other site 476213004103 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 476213004104 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 476213004105 Coenzyme A binding pocket [chemical binding]; other site 476213004106 hypothetical protein; Provisional; Region: PRK10404 476213004107 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 476213004108 isochorismate synthases; Region: isochor_syn; TIGR00543 476213004109 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 476213004110 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 476213004111 dimer interface [polypeptide binding]; other site 476213004112 tetramer interface [polypeptide binding]; other site 476213004113 PYR/PP interface [polypeptide binding]; other site 476213004114 TPP binding site [chemical binding]; other site 476213004115 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 476213004116 TPP-binding site; other site 476213004117 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 476213004118 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 476213004119 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 476213004120 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 476213004121 substrate binding site [chemical binding]; other site 476213004122 oxyanion hole (OAH) forming residues; other site 476213004123 trimer interface [polypeptide binding]; other site 476213004124 O-succinylbenzoate synthase [Coenzyme metabolism]; Region: MenC; COG1441 476213004125 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 476213004126 active site 476213004127 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 476213004128 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 476213004129 acyl-activating enzyme (AAE) consensus motif; other site 476213004130 putative AMP binding site [chemical binding]; other site 476213004131 putative active site [active] 476213004132 putative CoA binding site [chemical binding]; other site 476213004133 Polymyxin resistance protein PmrD; Region: PmrD; pfam11183 476213004134 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 476213004135 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 476213004136 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 476213004137 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 476213004138 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 476213004139 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 476213004140 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 476213004141 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 476213004142 active site 476213004143 substrate binding site [chemical binding]; other site 476213004144 cosubstrate binding site; other site 476213004145 catalytic site [active] 476213004146 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 476213004147 active site 476213004148 hexamer interface [polypeptide binding]; other site 476213004149 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 476213004150 NAD binding site [chemical binding]; other site 476213004151 substrate binding site [chemical binding]; other site 476213004152 active site 476213004153 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 476213004154 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 476213004155 Ligand binding site; other site 476213004156 Putative Catalytic site; other site 476213004157 DXD motif; other site 476213004158 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 476213004159 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 476213004160 inhibitor-cofactor binding pocket; inhibition site 476213004161 pyridoxal 5'-phosphate binding site [chemical binding]; other site 476213004162 catalytic residue [active] 476213004163 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 476213004164 catalytic core [active] 476213004165 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 476213004166 YfaZ precursor; Region: YfaZ; pfam07437 476213004167 hypothetical protein; Provisional; Region: PRK03673 476213004168 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 476213004169 putative MPT binding site; other site 476213004170 Competence-damaged protein; Region: CinA; cl00666 476213004171 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 476213004172 Transcriptional regulator [Transcription]; Region: IclR; COG1414 476213004173 Bacterial transcriptional regulator; Region: IclR; pfam01614 476213004174 L-rhamnonate dehydratase; Provisional; Region: PRK15440 476213004175 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 476213004176 putative active site pocket [active] 476213004177 putative metal binding site [ion binding]; other site 476213004178 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 476213004179 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213004180 putative substrate translocation pore; other site 476213004181 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 476213004182 hypothetical protein; Provisional; Region: PRK03673 476213004183 deubiquitinase SseL; Provisional; Region: PRK14848 476213004184 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 476213004185 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 476213004186 Cysteine-rich domain; Region: CCG; pfam02754 476213004187 Cysteine-rich domain; Region: CCG; pfam02754 476213004188 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 476213004189 FAD binding domain; Region: FAD_binding_2; pfam00890 476213004190 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 476213004191 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 476213004192 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 476213004193 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213004194 putative substrate translocation pore; other site 476213004195 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 476213004196 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 476213004197 active site 476213004198 catalytic site [active] 476213004199 metal binding site [ion binding]; metal-binding site 476213004200 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 476213004201 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213004202 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 476213004203 dimerization interface [polypeptide binding]; other site 476213004204 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 476213004205 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213004206 putative substrate translocation pore; other site 476213004207 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 476213004208 catalytic loop [active] 476213004209 iron binding site [ion binding]; other site 476213004210 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 476213004211 dimer interface [polypeptide binding]; other site 476213004212 putative radical transfer pathway; other site 476213004213 diiron center [ion binding]; other site 476213004214 tyrosyl radical; other site 476213004215 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 476213004216 ATP cone domain; Region: ATP-cone; pfam03477 476213004217 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 476213004218 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 476213004219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 476213004220 S-adenosylmethionine binding site [chemical binding]; other site 476213004221 Transcriptional regulators [Transcription]; Region: GntR; COG1802 476213004222 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 476213004223 DNA-binding site [nucleotide binding]; DNA binding site 476213004224 FCD domain; Region: FCD; pfam07729 476213004225 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 476213004226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213004227 putative substrate translocation pore; other site 476213004228 DNA gyrase subunit A; Validated; Region: PRK05560 476213004229 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 476213004230 CAP-like domain; other site 476213004231 active site 476213004232 primary dimer interface [polypeptide binding]; other site 476213004233 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 476213004234 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 476213004235 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 476213004236 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 476213004237 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 476213004238 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 476213004239 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 476213004240 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 476213004241 dimer interface [polypeptide binding]; other site 476213004242 phosphorylation site [posttranslational modification] 476213004243 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 476213004244 ATP binding site [chemical binding]; other site 476213004245 Mg2+ binding site [ion binding]; other site 476213004246 G-X-G motif; other site 476213004247 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 476213004248 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 476213004249 active site 476213004250 phosphorylation site [posttranslational modification] 476213004251 intermolecular recognition site; other site 476213004252 dimerization interface [polypeptide binding]; other site 476213004253 transcriptional regulator RcsB; Provisional; Region: PRK10840 476213004254 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 476213004255 active site 476213004256 phosphorylation site [posttranslational modification] 476213004257 intermolecular recognition site; other site 476213004258 dimerization interface [polypeptide binding]; other site 476213004259 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 476213004260 DNA binding residues [nucleotide binding] 476213004261 dimerization interface [polypeptide binding]; other site 476213004262 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 476213004263 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 476213004264 ATP binding site [chemical binding]; other site 476213004265 G-X-G motif; other site 476213004266 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 476213004267 putative binding surface; other site 476213004268 active site 476213004269 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 476213004270 trimer interface [polypeptide binding]; other site 476213004271 eyelet of channel; other site 476213004272 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 476213004273 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 476213004274 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 476213004275 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213004276 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 476213004277 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 476213004278 DNA binding site [nucleotide binding] 476213004279 active site 476213004280 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 476213004281 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 476213004282 Walker A/P-loop; other site 476213004283 ATP binding site [chemical binding]; other site 476213004284 Q-loop/lid; other site 476213004285 ABC transporter signature motif; other site 476213004286 Walker B; other site 476213004287 D-loop; other site 476213004288 H-loop/switch region; other site 476213004289 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 476213004290 secondary substrate binding site; other site 476213004291 primary substrate binding site; other site 476213004292 inhibition loop; other site 476213004293 dimerization interface [polypeptide binding]; other site 476213004294 ferredoxin-type protein; Provisional; Region: PRK10194 476213004295 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 476213004296 4Fe-4S binding domain; Region: Fer4; pfam00037 476213004297 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 476213004298 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 476213004299 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 476213004300 [4Fe-4S] binding site [ion binding]; other site 476213004301 molybdopterin cofactor binding site; other site 476213004302 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 476213004303 molybdopterin cofactor binding site; other site 476213004304 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 476213004305 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 476213004306 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 476213004307 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 476213004308 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 476213004309 4Fe-4S binding domain; Region: Fer4_5; pfam12801 476213004310 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 476213004311 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 476213004312 cytochrome c-type protein NapC; Provisional; Region: PRK10617 476213004313 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 476213004314 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 476213004315 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 476213004316 Walker A/P-loop; other site 476213004317 ATP binding site [chemical binding]; other site 476213004318 Q-loop/lid; other site 476213004319 ABC transporter signature motif; other site 476213004320 Walker B; other site 476213004321 D-loop; other site 476213004322 H-loop/switch region; other site 476213004323 heme exporter protein CcmB; Region: ccmB; TIGR01190 476213004324 heme exporter protein CcmC; Region: ccmC; TIGR01191 476213004325 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 476213004326 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150 476213004327 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 476213004328 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 476213004329 catalytic residues [active] 476213004330 central insert; other site 476213004331 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 476213004332 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 476213004333 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 476213004334 binding surface 476213004335 TPR motif; other site 476213004336 transcriptional regulator NarP; Provisional; Region: PRK10403 476213004337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 476213004338 active site 476213004339 phosphorylation site [posttranslational modification] 476213004340 intermolecular recognition site; other site 476213004341 dimerization interface [polypeptide binding]; other site 476213004342 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 476213004343 DNA binding residues [nucleotide binding] 476213004344 dimerization interface [polypeptide binding]; other site 476213004345 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 476213004346 DinI-like family; Region: DinI; cl11630 476213004347 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 476213004348 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 476213004349 E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387 476213004350 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 476213004351 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 476213004352 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 476213004353 Leucine-rich repeats; other site 476213004354 Substrate binding site [chemical binding]; other site 476213004355 C-terminal novel E3 ligase, LRR-interacting; Region: NEL; pfam14496 476213004356 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 476213004357 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 476213004358 Sulfatase; Region: Sulfatase; cl19157 476213004359 hypothetical protein; Provisional; Region: PRK13689 476213004360 nucleoid-associated protein NdpA; Validated; Region: PRK00378 476213004361 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 476213004362 5S rRNA interface [nucleotide binding]; other site 476213004363 CTC domain interface [polypeptide binding]; other site 476213004364 L16 interface [polypeptide binding]; other site 476213004365 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 476213004366 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 476213004367 ATP binding site [chemical binding]; other site 476213004368 putative Mg++ binding site [ion binding]; other site 476213004369 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 476213004370 nucleotide binding region [chemical binding]; other site 476213004371 ATP-binding site [chemical binding]; other site 476213004372 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 476213004373 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 476213004374 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 476213004375 RNA binding surface [nucleotide binding]; other site 476213004376 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 476213004377 active site 476213004378 uracil binding [chemical binding]; other site 476213004379 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213004380 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 476213004381 putative substrate translocation pore; other site 476213004382 hypothetical protein; Provisional; Region: PRK11835 476213004383 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 476213004384 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 476213004385 Walker A/P-loop; other site 476213004386 ATP binding site [chemical binding]; other site 476213004387 Q-loop/lid; other site 476213004388 ABC transporter signature motif; other site 476213004389 Walker B; other site 476213004390 D-loop; other site 476213004391 H-loop/switch region; other site 476213004392 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 476213004393 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 476213004394 Walker A/P-loop; other site 476213004395 ATP binding site [chemical binding]; other site 476213004396 Q-loop/lid; other site 476213004397 ABC transporter signature motif; other site 476213004398 Walker B; other site 476213004399 D-loop; other site 476213004400 H-loop/switch region; other site 476213004401 microcin C ABC transporter permease; Provisional; Region: PRK15021 476213004402 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213004403 dimer interface [polypeptide binding]; other site 476213004404 conserved gate region; other site 476213004405 putative PBP binding loops; other site 476213004406 ABC-ATPase subunit interface; other site 476213004407 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 476213004408 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213004409 dimer interface [polypeptide binding]; other site 476213004410 conserved gate region; other site 476213004411 putative PBP binding loops; other site 476213004412 ABC-ATPase subunit interface; other site 476213004413 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 476213004414 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 476213004415 phage resistance protein; Provisional; Region: PRK10551 476213004416 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 476213004417 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 476213004418 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 476213004419 NlpC/P60 family; Region: NLPC_P60; pfam00877 476213004420 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 476213004421 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 476213004422 active site 476213004423 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 476213004424 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 476213004425 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 476213004426 elongation factor P; Provisional; Region: PRK04542 476213004427 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 476213004428 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 476213004429 RNA binding site [nucleotide binding]; other site 476213004430 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 476213004431 RNA binding site [nucleotide binding]; other site 476213004432 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 476213004433 sugar efflux transporter B; Provisional; Region: PRK15011 476213004434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213004435 putative substrate translocation pore; other site 476213004436 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 476213004437 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 476213004438 active site 476213004439 phosphorylation site [posttranslational modification] 476213004440 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 476213004441 dimerization domain swap beta strand [polypeptide binding]; other site 476213004442 regulatory protein interface [polypeptide binding]; other site 476213004443 active site 476213004444 regulatory phosphorylation site [posttranslational modification]; other site 476213004445 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 476213004446 putative substrate binding site [chemical binding]; other site 476213004447 putative ATP binding site [chemical binding]; other site 476213004448 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 476213004449 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 476213004450 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 476213004451 active site 476213004452 P-loop; other site 476213004453 phosphorylation site [posttranslational modification] 476213004454 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 476213004455 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 476213004456 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 476213004457 AP (apurinic/apyrimidinic) site pocket; other site 476213004458 DNA interaction; other site 476213004459 Metal-binding active site; metal-binding site 476213004460 conserved hypothetical integral membrane protein; Region: TIGR00698 476213004461 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 476213004462 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213004463 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 476213004464 putative dimerization interface [polypeptide binding]; other site 476213004465 lysine transporter; Provisional; Region: PRK10836 476213004466 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 476213004467 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 476213004468 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 476213004469 N-terminal plug; other site 476213004470 ligand-binding site [chemical binding]; other site 476213004471 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 476213004472 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 476213004473 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 476213004474 motif II; other site 476213004475 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 476213004476 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 476213004477 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 476213004478 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 476213004479 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 476213004480 non-specific DNA binding site [nucleotide binding]; other site 476213004481 salt bridge; other site 476213004482 sequence-specific DNA binding site [nucleotide binding]; other site 476213004483 Predicted esterase [General function prediction only]; Region: COG0627 476213004484 S-formylglutathione hydrolase; Region: PLN02442 476213004485 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 476213004486 homodecamer interface [polypeptide binding]; other site 476213004487 active site 476213004488 putative catalytic site residues [active] 476213004489 zinc binding site [ion binding]; other site 476213004490 GTP-CH-I/GFRP interaction surface; other site 476213004491 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 476213004492 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 476213004493 ligand binding site [chemical binding]; other site 476213004494 calcium binding site [ion binding]; other site 476213004495 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 476213004496 TM-ABC transporter signature motif; other site 476213004497 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 476213004498 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 476213004499 homodimer interface [polypeptide binding]; other site 476213004500 active site 476213004501 FMN binding site [chemical binding]; other site 476213004502 substrate binding site [chemical binding]; other site 476213004503 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 476213004504 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 476213004505 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 476213004506 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 476213004507 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 476213004508 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 476213004509 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 476213004510 putative active site [active] 476213004511 cytidine deaminase; Provisional; Region: PRK09027 476213004512 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 476213004513 active site 476213004514 catalytic motif [active] 476213004515 Zn binding site [ion binding]; other site 476213004516 Cytidine and deoxycytidylate deaminase zinc-binding region; Region: dCMP_cyt_deam_2; pfam08211 476213004517 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 476213004518 active site 476213004519 catalytic motif [active] 476213004520 Zn binding site [ion binding]; other site 476213004521 hypothetical protein; Provisional; Region: PRK10711 476213004522 hypothetical protein; Provisional; Region: PRK01821 476213004523 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 476213004524 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213004525 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 476213004526 dimerization interface [polypeptide binding]; other site 476213004527 benzoate transport; Region: 2A0115; TIGR00895 476213004528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213004529 putative substrate translocation pore; other site 476213004530 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 476213004531 Cupin domain; Region: Cupin_2; pfam07883 476213004532 Cupin domain; Region: Cupin_2; cl17218 476213004533 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 476213004534 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 476213004535 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 476213004536 maleylacetoacetate isomerase; Region: maiA; TIGR01262 476213004537 C-terminal domain interface [polypeptide binding]; other site 476213004538 GSH binding site (G-site) [chemical binding]; other site 476213004539 putative dimer interface [polypeptide binding]; other site 476213004540 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 476213004541 dimer interface [polypeptide binding]; other site 476213004542 N-terminal domain interface [polypeptide binding]; other site 476213004543 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 476213004544 salicylate hydroxylase; Provisional; Region: PRK08163 476213004545 Squalene epoxidase; Region: SE; cl17314 476213004546 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 476213004547 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 476213004548 FMN binding site [chemical binding]; other site 476213004549 active site 476213004550 catalytic residues [active] 476213004551 substrate binding site [chemical binding]; other site 476213004552 oxidoreductase; Provisional; Region: PRK12743 476213004553 classical (c) SDRs; Region: SDR_c; cd05233 476213004554 NAD(P) binding site [chemical binding]; other site 476213004555 active site 476213004556 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 476213004557 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 476213004558 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 476213004559 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 476213004560 D-lactate dehydrogenase; Provisional; Region: PRK11183 476213004561 FAD binding domain; Region: FAD_binding_4; cl19922 476213004562 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 476213004563 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 476213004564 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 476213004565 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 476213004566 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 476213004567 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 476213004568 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213004569 dimer interface [polypeptide binding]; other site 476213004570 conserved gate region; other site 476213004571 putative PBP binding loops; other site 476213004572 ABC-ATPase subunit interface; other site 476213004573 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 476213004574 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 476213004575 Walker A/P-loop; other site 476213004576 ATP binding site [chemical binding]; other site 476213004577 Q-loop/lid; other site 476213004578 ABC transporter signature motif; other site 476213004579 Walker B; other site 476213004580 D-loop; other site 476213004581 H-loop/switch region; other site 476213004582 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 476213004583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213004584 dimer interface [polypeptide binding]; other site 476213004585 conserved gate region; other site 476213004586 putative PBP binding loops; other site 476213004587 ABC-ATPase subunit interface; other site 476213004588 transcriptional regulator MirA; Provisional; Region: PRK15043 476213004589 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 476213004590 DNA binding residues [nucleotide binding] 476213004591 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 476213004592 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 476213004593 GAF domain; Region: GAF; pfam01590 476213004594 Histidine kinase; Region: His_kinase; pfam06580 476213004595 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 476213004596 ATP binding site [chemical binding]; other site 476213004597 Mg2+ binding site [ion binding]; other site 476213004598 G-X-G motif; other site 476213004599 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 476213004600 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 476213004601 active site 476213004602 phosphorylation site [posttranslational modification] 476213004603 intermolecular recognition site; other site 476213004604 dimerization interface [polypeptide binding]; other site 476213004605 LytTr DNA-binding domain; Region: LytTR; pfam04397 476213004606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 476213004607 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 476213004608 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 476213004609 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 476213004610 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 476213004611 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 476213004612 active site 476213004613 HIGH motif; other site 476213004614 KMSKS motif; other site 476213004615 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 476213004616 tRNA binding surface [nucleotide binding]; other site 476213004617 anticodon binding site; other site 476213004618 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 476213004619 dimer interface [polypeptide binding]; other site 476213004620 putative tRNA-binding site [nucleotide binding]; other site 476213004621 antiporter inner membrane protein; Provisional; Region: PRK11670 476213004622 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 476213004623 Walker A motif; other site 476213004624 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 476213004625 fimbrial chaperone protein; Provisional; Region: PRK15220 476213004626 putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253 476213004627 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 476213004628 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 476213004629 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 476213004630 Predicted integral membrane protein [Function unknown]; Region: COG5455 476213004631 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 476213004632 substrate binding site [chemical binding]; other site 476213004633 multimerization interface [polypeptide binding]; other site 476213004634 ATP binding site [chemical binding]; other site 476213004635 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 476213004636 dimer interface [polypeptide binding]; other site 476213004637 substrate binding site [chemical binding]; other site 476213004638 ATP binding site [chemical binding]; other site 476213004639 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 476213004640 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 476213004641 DNA-binding site [nucleotide binding]; DNA binding site 476213004642 UTRA domain; Region: UTRA; pfam07702 476213004643 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 476213004644 substrate binding site [chemical binding]; other site 476213004645 ATP binding site [chemical binding]; other site 476213004646 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 476213004647 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 476213004648 putative active site; other site 476213004649 catalytic residue [active] 476213004650 lipid kinase; Reviewed; Region: PRK13054 476213004651 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 476213004652 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 476213004653 type III secretion system protein; Provisional; Region: PRK15383; cl14665 476213004654 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 476213004655 putative protease; Provisional; Region: PRK15452 476213004656 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 476213004657 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 476213004658 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 476213004659 putative lyase; Provisional; Region: PRK09687 476213004660 Parkin co-regulated protein; Region: ParcG; pfam10274 476213004661 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 476213004662 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 476213004663 Tetratricopeptide repeat; Region: TPR_12; pfam13424 476213004664 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 476213004665 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 476213004666 PcfJ-like protein; Region: PcfJ; pfam14284 476213004667 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 476213004668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 476213004669 active site 476213004670 phosphorylation site [posttranslational modification] 476213004671 intermolecular recognition site; other site 476213004672 dimerization interface [polypeptide binding]; other site 476213004673 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 476213004674 DNA binding site [nucleotide binding] 476213004675 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 476213004676 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 476213004677 dimerization interface [polypeptide binding]; other site 476213004678 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 476213004679 dimer interface [polypeptide binding]; other site 476213004680 phosphorylation site [posttranslational modification] 476213004681 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 476213004682 ATP binding site [chemical binding]; other site 476213004683 Mg2+ binding site [ion binding]; other site 476213004684 G-X-G motif; other site 476213004685 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 476213004686 MMPL family; Region: MMPL; cl14618 476213004687 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 476213004688 MMPL family; Region: MMPL; cl14618 476213004689 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 476213004690 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 476213004691 HlyD family secretion protein; Region: HlyD_3; pfam13437 476213004692 putative chaperone; Provisional; Region: PRK11678 476213004693 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 476213004694 nucleotide binding site [chemical binding]; other site 476213004695 putative NEF/HSP70 interaction site [polypeptide binding]; other site 476213004696 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 476213004697 SBD interface [polypeptide binding]; other site 476213004698 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 476213004699 AlkA N-terminal domain; Region: AlkA_N; pfam06029 476213004700 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 476213004701 minor groove reading motif; other site 476213004702 helix-hairpin-helix signature motif; other site 476213004703 substrate binding pocket [chemical binding]; other site 476213004704 active site 476213004705 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 476213004706 putative diguanylate cyclase; Provisional; Region: PRK09776 476213004707 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 476213004708 putative active site [active] 476213004709 heme pocket [chemical binding]; other site 476213004710 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 476213004711 putative active site [active] 476213004712 heme pocket [chemical binding]; other site 476213004713 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 476213004714 metal binding site [ion binding]; metal-binding site 476213004715 active site 476213004716 I-site; other site 476213004717 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 476213004718 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 476213004719 ATP-binding site [chemical binding]; other site 476213004720 Sugar specificity; other site 476213004721 Pyrimidine base specificity; other site 476213004722 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 476213004723 trimer interface [polypeptide binding]; other site 476213004724 active site 476213004725 putative assembly protein; Provisional; Region: PRK10833 476213004726 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 476213004727 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 476213004728 FOG: CBS domain [General function prediction only]; Region: COG0517 476213004729 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 476213004730 Transporter associated domain; Region: CorC_HlyC; smart01091 476213004731 polysaccharide export protein Wza; Provisional; Region: PRK15078 476213004732 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 476213004733 SLBB domain; Region: SLBB; pfam10531 476213004734 Low molecular weight phosphatase family; Region: LMWPc; cd00115 476213004735 active site 476213004736 tyrosine kinase; Provisional; Region: PRK11519 476213004737 Chain length determinant protein; Region: Wzz; pfam02706 476213004738 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 476213004739 AAA domain; Region: AAA_31; pfam13614 476213004740 putative glycosyl transferase; Provisional; Region: PRK10018 476213004741 colanic acid biosynthesis glycosyl transferase WcaA; Region: WcaA; TIGR04017 476213004742 active site 476213004743 putative acyl transferase; Provisional; Region: PRK10191 476213004744 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 476213004745 trimer interface [polypeptide binding]; other site 476213004746 active site 476213004747 substrate binding site [chemical binding]; other site 476213004748 CoA binding site [chemical binding]; other site 476213004749 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 476213004750 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 476213004751 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 476213004752 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 476213004753 colanic acid biosynthesis glycosyl transferase WcaE; Region: wcaE; TIGR04009 476213004754 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 476213004755 metal-binding site 476213004756 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 476213004757 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 476213004758 putative trimer interface [polypeptide binding]; other site 476213004759 putative active site [active] 476213004760 putative substrate binding site [chemical binding]; other site 476213004761 putative CoA binding site [chemical binding]; other site 476213004762 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 476213004763 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 476213004764 NADP-binding site; other site 476213004765 homotetramer interface [polypeptide binding]; other site 476213004766 substrate binding site [chemical binding]; other site 476213004767 homodimer interface [polypeptide binding]; other site 476213004768 active site 476213004769 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 476213004770 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 476213004771 NADP binding site [chemical binding]; other site 476213004772 active site 476213004773 putative substrate binding site [chemical binding]; other site 476213004774 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 476213004775 nudix motif; other site 476213004776 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 476213004777 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 476213004778 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 476213004779 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 476213004780 Substrate binding site; other site 476213004781 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 476213004782 phosphomannomutase CpsG; Provisional; Region: PRK15414 476213004783 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 476213004784 active site 476213004785 substrate binding site [chemical binding]; other site 476213004786 metal binding site [ion binding]; metal-binding site 476213004787 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 476213004788 CoA-binding domain; Region: CoA_binding_3; pfam13727 476213004789 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 476213004790 colanic acid exporter; Provisional; Region: PRK10459 476213004791 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 476213004792 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 476213004793 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 476213004794 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 476213004795 putative ADP-binding pocket [chemical binding]; other site 476213004796 colanic acid biosynthesis protein WcaM; Region: WcaM; TIGR04004 476213004797 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 476213004798 active site 476213004799 tetramer interface; other site 476213004800 EpsG family; Region: EpsG; pfam14897 476213004801 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 476213004802 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 476213004803 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 476213004804 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 476213004805 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 476213004806 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 476213004807 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 476213004808 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 476213004809 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 476213004810 Substrate binding site; other site 476213004811 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 476213004812 phosphomannomutase CpsG; Provisional; Region: PRK15414 476213004813 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 476213004814 active site 476213004815 substrate binding site [chemical binding]; other site 476213004816 metal binding site [ion binding]; metal-binding site 476213004817 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 476213004818 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 476213004819 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 476213004820 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 476213004821 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 476213004822 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 476213004823 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 476213004824 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 476213004825 chain length determinant protein WzzB; Provisional; Region: PRK15471 476213004826 Chain length determinant protein; Region: Wzz; pfam02706 476213004827 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 476213004828 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 476213004829 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 476213004830 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 476213004831 metal binding site [ion binding]; metal-binding site 476213004832 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 476213004833 substrate binding site [chemical binding]; other site 476213004834 glutamase interaction surface [polypeptide binding]; other site 476213004835 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 476213004836 catalytic residues [active] 476213004837 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 476213004838 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 476213004839 putative active site [active] 476213004840 oxyanion strand; other site 476213004841 catalytic triad [active] 476213004842 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 476213004843 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 476213004844 active site 476213004845 motif I; other site 476213004846 motif II; other site 476213004847 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 476213004848 putative active site pocket [active] 476213004849 4-fold oligomerization interface [polypeptide binding]; other site 476213004850 metal binding residues [ion binding]; metal-binding site 476213004851 3-fold/trimer interface [polypeptide binding]; other site 476213004852 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 476213004853 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 476213004854 pyridoxal 5'-phosphate binding site [chemical binding]; other site 476213004855 homodimer interface [polypeptide binding]; other site 476213004856 catalytic residue [active] 476213004857 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 476213004858 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 476213004859 NAD binding site [chemical binding]; other site 476213004860 dimerization interface [polypeptide binding]; other site 476213004861 product binding site; other site 476213004862 substrate binding site [chemical binding]; other site 476213004863 zinc binding site [ion binding]; other site 476213004864 catalytic residues [active] 476213004865 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 476213004866 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 476213004867 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 476213004868 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 476213004869 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 476213004870 putative NAD(P) binding site [chemical binding]; other site 476213004871 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213004872 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 476213004873 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 476213004874 dimerization interface [polypeptide binding]; other site 476213004875 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 476213004876 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 476213004877 exonuclease I; Provisional; Region: sbcB; PRK11779 476213004878 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 476213004879 active site 476213004880 catalytic site [active] 476213004881 substrate binding site [chemical binding]; other site 476213004882 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 476213004883 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 476213004884 thiosulfate reductase PhsA; Provisional; Region: PRK15488 476213004885 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 476213004886 putative [Fe4-S4] binding site [ion binding]; other site 476213004887 putative molybdopterin cofactor binding site [chemical binding]; other site 476213004888 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 476213004889 putative molybdopterin cofactor binding site; other site 476213004890 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 476213004891 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 476213004892 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 476213004893 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 476213004894 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 476213004895 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 476213004896 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 476213004897 DNA gyrase inhibitor; Provisional; Region: PRK10016 476213004898 Predicted membrane protein [Function unknown]; Region: COG1289 476213004899 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 476213004900 hypothetical protein; Provisional; Region: PRK05423 476213004901 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 476213004902 propionate kinase; Reviewed; Region: PRK12397 476213004903 Ethanolamine utilisation - propanediol utilisation; Region: PduV-EutP; pfam10662 476213004904 G3 box; other site 476213004905 Switch II region; other site 476213004906 GTP/Mg2+ binding site [chemical binding]; other site 476213004907 G4 box; other site 476213004908 G5 box; other site 476213004909 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 476213004910 putative hexamer interface [polypeptide binding]; other site 476213004911 putative hexagonal pore; other site 476213004912 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 476213004913 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 476213004914 putative hexamer interface [polypeptide binding]; other site 476213004915 putative hexagonal pore; other site 476213004916 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 476213004917 putative hexamer interface [polypeptide binding]; other site 476213004918 putative hexagonal pore; other site 476213004919 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 476213004920 SLBB domain; Region: SLBB; pfam10531 476213004921 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 476213004922 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 476213004923 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 476213004924 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 476213004925 putative active site [active] 476213004926 metal binding site [ion binding]; metal-binding site 476213004927 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 476213004928 putative catalytic cysteine [active] 476213004929 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 476213004930 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 476213004931 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 476213004932 Hexamer/Pentamer interface [polypeptide binding]; other site 476213004933 central pore; other site 476213004934 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 476213004935 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 476213004936 Propanediol utilisation protein PduL; Region: PduL; pfam06130 476213004937 Propanediol utilisation protein PduL; Region: PduL; pfam06130 476213004938 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 476213004939 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 476213004940 putative hexamer interface [polypeptide binding]; other site 476213004941 putative hexagonal pore; other site 476213004942 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 476213004943 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 476213004944 Hexamer interface [polypeptide binding]; other site 476213004945 Hexagonal pore residue; other site 476213004946 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 476213004947 Cell division protein FtsA; Region: FtsA; cl17206 476213004948 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 476213004949 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 476213004950 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 476213004951 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 476213004952 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 476213004953 alpha-beta subunit interface [polypeptide binding]; other site 476213004954 alpha-gamma subunit interface [polypeptide binding]; other site 476213004955 active site 476213004956 substrate and K+ binding site; other site 476213004957 K+ binding site [ion binding]; other site 476213004958 cobalamin binding site [chemical binding]; other site 476213004959 propanediol utilization protein PduB; Provisional; Region: PRK15415 476213004960 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 476213004961 putative hexamer interface [polypeptide binding]; other site 476213004962 putative hexagonal pore; other site 476213004963 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 476213004964 putative hexamer interface [polypeptide binding]; other site 476213004965 putative hexagonal pore; other site 476213004966 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 476213004967 Hexamer interface [polypeptide binding]; other site 476213004968 Hexagonal pore residue; other site 476213004969 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 476213004970 amphipathic channel; other site 476213004971 Asn-Pro-Ala signature motifs; other site 476213004972 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 476213004973 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213004974 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 476213004975 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213004976 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 476213004977 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 476213004978 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 476213004979 catalytic triad [active] 476213004980 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 476213004981 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 476213004982 Cobalamin biosynthesis protein CbiD [Coenzyme metabolism]; Region: CbiD; COG1903 476213004983 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 476213004984 active site 476213004985 putative homodimer interface [polypeptide binding]; other site 476213004986 SAM binding site [chemical binding]; other site 476213004987 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 476213004988 S-adenosylmethionine binding site [chemical binding]; other site 476213004989 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 476213004990 active site 476213004991 SAM binding site [chemical binding]; other site 476213004992 homodimer interface [polypeptide binding]; other site 476213004993 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 476213004994 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 476213004995 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 476213004996 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 476213004997 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 476213004998 active site 476213004999 SAM binding site [chemical binding]; other site 476213005000 homodimer interface [polypeptide binding]; other site 476213005001 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 476213005002 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 476213005003 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 476213005004 active site 476213005005 C-terminal domain interface [polypeptide binding]; other site 476213005006 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 476213005007 active site 476213005008 N-terminal domain interface [polypeptide binding]; other site 476213005009 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 476213005010 active site 476213005011 SAM binding site [chemical binding]; other site 476213005012 homodimer interface [polypeptide binding]; other site 476213005013 cobalt transport protein CbiM; Validated; Region: PRK08319 476213005014 cobalt transport protein CbiN; Provisional; Region: PRK02898 476213005015 cobalt transport protein CbiQ; Provisional; Region: PRK15485 476213005016 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 476213005017 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 476213005018 Walker A/P-loop; other site 476213005019 ATP binding site [chemical binding]; other site 476213005020 Q-loop/lid; other site 476213005021 ABC transporter signature motif; other site 476213005022 Walker B; other site 476213005023 D-loop; other site 476213005024 H-loop/switch region; other site 476213005025 cobyric acid synthase; Provisional; Region: PRK00784 476213005026 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 476213005027 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 476213005028 catalytic triad [active] 476213005029 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 476213005030 homotrimer interface [polypeptide binding]; other site 476213005031 Walker A motif; other site 476213005032 GTP binding site [chemical binding]; other site 476213005033 Walker B motif; other site 476213005034 cobalamin synthase; Reviewed; Region: cobS; PRK00235 476213005035 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 476213005036 putative dimer interface [polypeptide binding]; other site 476213005037 active site pocket [active] 476213005038 putative cataytic base [active] 476213005039 L,D-transpeptidase; Provisional; Region: PRK10190 476213005040 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 476213005041 MATE family multidrug exporter; Provisional; Region: PRK10189 476213005042 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 476213005043 Phage integrase, N-terminal; Region: Phage_int_SAM_2; pfam12834 476213005044 Integrase; Region: Integrase_1; pfam12835 476213005045 DDE superfamily endonuclease; Region: DDE_3; cl19249 476213005046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 476213005047 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 476213005048 Sel1 repeat; Region: Sel1; pfam08238 476213005049 Sel1-like repeats; Region: SEL1; smart00671 476213005050 AMP nucleosidase; Provisional; Region: PRK08292 476213005051 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 476213005052 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 476213005053 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 476213005054 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 476213005055 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 476213005056 Catalytic site [active] 476213005057 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 476213005058 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 476213005059 active site 476213005060 DNA binding site [nucleotide binding] 476213005061 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 476213005062 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 476213005063 DNA-binding site [nucleotide binding]; DNA binding site 476213005064 RNA-binding motif; other site 476213005065 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 476213005066 trimer interface [polypeptide binding]; other site 476213005067 eyelet of channel; other site 476213005068 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 476213005069 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 476213005070 Zn2+ binding site [ion binding]; other site 476213005071 Mg2+ binding site [ion binding]; other site 476213005072 DNA cytosine methylase; Provisional; Region: PRK10458 476213005073 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 476213005074 cofactor binding site; other site 476213005075 DNA binding site [nucleotide binding] 476213005076 substrate interaction site [chemical binding]; other site 476213005077 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 476213005078 additional DNA contacts [nucleotide binding]; other site 476213005079 mismatch recognition site; other site 476213005080 active site 476213005081 zinc binding site [ion binding]; other site 476213005082 DNA intercalation site [nucleotide binding]; other site 476213005083 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 476213005084 EamA-like transporter family; Region: EamA; pfam00892 476213005085 EamA-like transporter family; Region: EamA; pfam00892 476213005086 Uncharacterized small protein [Function unknown]; Region: COG5475 476213005087 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 476213005088 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 476213005089 metal binding site [ion binding]; metal-binding site 476213005090 active site 476213005091 I-site; other site 476213005092 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 476213005093 mannosyl-3-phosphoglycerate phosphatase family; Region: HAD-SF-IIB-MPGP; TIGR01486 476213005094 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 476213005095 active site 476213005096 motif I; other site 476213005097 motif II; other site 476213005098 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 476213005099 hypothetical protein; Provisional; Region: PRK10708 476213005100 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 476213005101 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 476213005102 DNA binding residues [nucleotide binding] 476213005103 dimerization interface [polypeptide binding]; other site 476213005104 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 476213005105 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 476213005106 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 476213005107 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 476213005108 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 476213005109 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 476213005110 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 476213005111 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 476213005112 flagellar hook-length control protein; Provisional; Region: PRK10118 476213005113 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 476213005114 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 476213005115 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 476213005116 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 476213005117 Walker A motif/ATP binding site; other site 476213005118 Walker B motif; other site 476213005119 flagellar assembly protein H; Validated; Region: fliH; PRK05687 476213005120 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 476213005121 Flagellar assembly protein FliH; Region: FliH; pfam02108 476213005122 flagellar motor switch protein FliG; Region: fliG; TIGR00207 476213005123 FliG N-terminal domain; Region: FliG_N; pfam14842 476213005124 FliG middle domain; Region: FliG_M; pfam14841 476213005125 FliG C-terminal domain; Region: FliG_C; pfam01706 476213005126 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 476213005127 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 476213005128 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 476213005129 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 476213005130 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 476213005131 CPxP motif; other site 476213005132 putative inner membrane protein; Provisional; Region: PRK11099 476213005133 Predicted transporter component [General function prediction only]; Region: COG2391 476213005134 lipoprotein; Provisional; Region: PRK10397 476213005135 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 476213005136 flagellar protein FliS; Validated; Region: fliS; PRK05685 476213005137 flagellar capping protein; Reviewed; Region: fliD; PRK08032 476213005138 Flagellar hook-associated protein 2 N-terminus; Region: FliD_N; pfam02465 476213005139 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 476213005140 flagellin; Validated; Region: PRK08026 476213005141 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 476213005142 Flagellin D3 domain; Region: Flagellin_D3; pfam08884 476213005143 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 476213005144 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 476213005145 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 476213005146 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 476213005147 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 476213005148 DNA binding residues [nucleotide binding] 476213005149 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 476213005150 cystine transporter subunit; Provisional; Region: PRK11260 476213005151 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 476213005152 substrate binding pocket [chemical binding]; other site 476213005153 membrane-bound complex binding site; other site 476213005154 hinge residues; other site 476213005155 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 476213005156 pyridoxal 5'-phosphate binding site [chemical binding]; other site 476213005157 catalytic residue [active] 476213005158 amino acid ABC transporter permease; Provisional; Region: PRK15100 476213005159 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213005160 dimer interface [polypeptide binding]; other site 476213005161 conserved gate region; other site 476213005162 putative PBP binding loops; other site 476213005163 ABC-ATPase subunit interface; other site 476213005164 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 476213005165 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 476213005166 Walker A/P-loop; other site 476213005167 ATP binding site [chemical binding]; other site 476213005168 Q-loop/lid; other site 476213005169 ABC transporter signature motif; other site 476213005170 Walker B; other site 476213005171 D-loop; other site 476213005172 H-loop/switch region; other site 476213005173 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 476213005174 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 476213005175 Autoinducer binding domain; Region: Autoind_bind; pfam03472 476213005176 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 476213005177 DNA binding residues [nucleotide binding] 476213005178 dimerization interface [polypeptide binding]; other site 476213005179 hypothetical protein; Provisional; Region: PRK10613 476213005180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 476213005181 response regulator; Provisional; Region: PRK09483 476213005182 active site 476213005183 phosphorylation site [posttranslational modification] 476213005184 intermolecular recognition site; other site 476213005185 dimerization interface [polypeptide binding]; other site 476213005186 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 476213005187 DNA binding residues [nucleotide binding] 476213005188 dimerization interface [polypeptide binding]; other site 476213005189 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 476213005190 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 476213005191 GIY-YIG motif/motif A; other site 476213005192 active site 476213005193 catalytic site [active] 476213005194 putative DNA binding site [nucleotide binding]; other site 476213005195 metal binding site [ion binding]; metal-binding site 476213005196 UvrB/uvrC motif; Region: UVR; pfam02151 476213005197 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 476213005198 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 476213005199 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 476213005200 glucose-6-phosphate 1-dehydrogenase; Region: PLN02640 476213005201 hypothetical protein; Provisional; Region: PRK10396 476213005202 yecA family protein; Region: ygfB_yecA; TIGR02292 476213005203 SEC-C motif; Region: SEC-C; pfam02810 476213005204 tyrosine transporter TyrP; Provisional; Region: PRK15132 476213005205 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 476213005206 probable metal-binding protein; Region: matur_matur; TIGR03853 476213005207 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 476213005208 Ferritin-like domain; Region: Ferritin; pfam00210 476213005209 ferroxidase diiron center [ion binding]; other site 476213005210 YecR-like lipoprotein; Region: YecR; pfam13992 476213005211 hypothetical protein; Provisional; Region: PRK09273 476213005212 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 476213005213 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 476213005214 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 476213005215 Ferritin-like domain; Region: Ferritin; pfam00210 476213005216 ferroxidase diiron center [ion binding]; other site 476213005217 DJ-1 family protein; Region: not_thiJ; TIGR01383 476213005218 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 476213005219 conserved cys residue [active] 476213005220 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 476213005221 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 476213005222 active site 476213005223 motif I; other site 476213005224 motif II; other site 476213005225 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 476213005226 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 476213005227 active site 476213005228 homotetramer interface [polypeptide binding]; other site 476213005229 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 476213005230 Ligand Binding Site [chemical binding]; other site 476213005231 transcriptional activator FlhD; Provisional; Region: PRK02909 476213005232 transcriptional activator FlhC; Provisional; Region: PRK12722 476213005233 flagellar motor protein MotA; Validated; Region: PRK09110 476213005234 flagellar motor protein MotB; Validated; Region: motB; PRK09041 476213005235 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 476213005236 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 476213005237 ligand binding site [chemical binding]; other site 476213005238 chemotaxis protein CheA; Provisional; Region: PRK10547 476213005239 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 476213005240 putative binding surface; other site 476213005241 active site 476213005242 CheY binding; Region: CheY-binding; pfam09078 476213005243 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 476213005244 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 476213005245 ATP binding site [chemical binding]; other site 476213005246 Mg2+ binding site [ion binding]; other site 476213005247 G-X-G motif; other site 476213005248 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 476213005249 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 476213005250 putative CheA interaction surface; other site 476213005251 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 476213005252 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 476213005253 dimer interface [polypeptide binding]; other site 476213005254 ligand binding site [chemical binding]; other site 476213005255 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 476213005256 dimerization interface [polypeptide binding]; other site 476213005257 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 476213005258 dimer interface [polypeptide binding]; other site 476213005259 putative CheW interface [polypeptide binding]; other site 476213005260 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 476213005261 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 476213005262 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 476213005263 S-adenosylmethionine binding site [chemical binding]; other site 476213005264 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 476213005265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 476213005266 active site 476213005267 phosphorylation site [posttranslational modification] 476213005268 intermolecular recognition site; other site 476213005269 dimerization interface [polypeptide binding]; other site 476213005270 CheB methylesterase; Region: CheB_methylest; pfam01339 476213005271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 476213005272 active site 476213005273 phosphorylation site [posttranslational modification] 476213005274 intermolecular recognition site; other site 476213005275 dimerization interface [polypeptide binding]; other site 476213005276 chemotaxis regulator CheZ; Provisional; Region: PRK11166 476213005277 FlhB HrpN YscU SpaS Family; Region: Bac_export_2; cl19167 476213005278 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 476213005279 Flagellar protein FlhE; Region: FlhE; pfam06366 476213005280 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 476213005281 penicillin-binding protein 2; Provisional; Region: PRK10795 476213005282 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 476213005283 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 476213005284 arginyl-tRNA synthetase; Region: argS; TIGR00456 476213005285 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 476213005286 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 476213005287 active site 476213005288 HIGH motif; other site 476213005289 KMSK motif region; other site 476213005290 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 476213005291 tRNA binding surface [nucleotide binding]; other site 476213005292 anticodon binding site; other site 476213005293 tRNA (mo5U34)-methyltransferase; Region: TIGR00452 476213005294 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 476213005295 S-adenosylmethionine binding site [chemical binding]; other site 476213005296 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 476213005297 S-adenosylmethionine binding site [chemical binding]; other site 476213005298 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 476213005299 hypothetical protein; Provisional; Region: PRK10302 476213005300 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 476213005301 catalytic triad [active] 476213005302 conserved cis-peptide bond; other site 476213005303 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 476213005304 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 476213005305 dimer interface [polypeptide binding]; other site 476213005306 anticodon binding site; other site 476213005307 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 476213005308 homodimer interface [polypeptide binding]; other site 476213005309 motif 1; other site 476213005310 active site 476213005311 motif 2; other site 476213005312 GAD domain; Region: GAD; pfam02938 476213005313 motif 3; other site 476213005314 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 476213005315 nudix motif; other site 476213005316 hypothetical protein; Validated; Region: PRK00110 476213005317 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 476213005318 active site 476213005319 putative DNA-binding cleft [nucleotide binding]; other site 476213005320 dimer interface [polypeptide binding]; other site 476213005321 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 476213005322 RuvA N terminal domain; Region: RuvA_N; pfam01330 476213005323 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 476213005324 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 476213005325 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 476213005326 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 476213005327 Walker A motif; other site 476213005328 ATP binding site [chemical binding]; other site 476213005329 Walker B motif; other site 476213005330 arginine finger; other site 476213005331 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 476213005332 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 476213005333 ABC-ATPase subunit interface; other site 476213005334 dimer interface [polypeptide binding]; other site 476213005335 putative PBP binding regions; other site 476213005336 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 476213005337 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 476213005338 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 476213005339 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 476213005340 metal binding site [ion binding]; metal-binding site 476213005341 putative peptidase; Provisional; Region: PRK11649 476213005342 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 476213005343 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 476213005344 Peptidase family M23; Region: Peptidase_M23; pfam01551 476213005345 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 476213005346 putative acyl-acceptor binding pocket; other site 476213005347 Integrase core domain; Region: rve; pfam00665 476213005348 Integrase core domain; Region: rve_3; pfam13683 476213005349 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 476213005350 Helix-turn-helix domain; Region: HTH_28; pfam13518 476213005351 pyruvate kinase; Provisional; Region: PRK05826 476213005352 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 476213005353 domain interfaces; other site 476213005354 active site 476213005355 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 476213005356 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 476213005357 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 476213005358 putative active site [active] 476213005359 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 476213005360 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 476213005361 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 476213005362 phosphogluconate dehydratase; Validated; Region: PRK09054 476213005363 Entner-Doudoroff aldolase; Region: eda; TIGR01182 476213005364 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 476213005365 active site 476213005366 intersubunit interface [polypeptide binding]; other site 476213005367 catalytic residue [active] 476213005368 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 476213005369 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 476213005370 ATP-grasp domain; Region: ATP-grasp; pfam02222 476213005371 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 476213005372 hypothetical protein; Provisional; Region: PRK13680 476213005373 Protein of unknown function (DUF533); Region: DUF533; pfam04391 476213005374 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 476213005375 putative metal binding site [ion binding]; other site 476213005376 protease 2; Provisional; Region: PRK10115 476213005377 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 476213005378 exodeoxyribonuclease X; Provisional; Region: PRK07983 476213005379 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 476213005380 active site 476213005381 catalytic site [active] 476213005382 substrate binding site [chemical binding]; other site 476213005383 Predicted amidohydrolase [General function prediction only]; Region: COG0388 476213005384 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 476213005385 hypothetical protein; Provisional; Region: PRK10301 476213005386 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 476213005387 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 476213005388 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 476213005389 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 476213005390 dimer interface [polypeptide binding]; other site 476213005391 active site 476213005392 Int/Topo IB signature motif; other site 476213005393 GldM C-terminal domain; Region: GldM_C; pfam12080 476213005394 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 476213005395 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 476213005396 Phage-encoded virulence factor; Region: PAGK; pfam15284 476213005397 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 476213005398 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 476213005399 substrate binding pocket [chemical binding]; other site 476213005400 membrane-bound complex binding site; other site 476213005401 hinge residues; other site 476213005402 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 476213005403 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 476213005404 DNA binding site [nucleotide binding] 476213005405 active site 476213005406 Int/Topo IB signature motif; other site 476213005407 RecT family; Region: RecT; cl04285 476213005408 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 476213005409 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 476213005410 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 476213005411 metal binding site [ion binding]; metal-binding site 476213005412 active site 476213005413 I-site; other site 476213005414 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 476213005415 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 476213005416 Alkyl sulfatase dimerization; Region: Alkyl_sulf_dimr; pfam14863 476213005417 Alkyl sulfatase C-terminal; Region: Alkyl_sulf_C; pfam14864 476213005418 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 476213005419 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 476213005420 EamA-like transporter family; Region: EamA; pfam00892 476213005421 EamA-like transporter family; Region: EamA; pfam00892 476213005422 Fimbrial protein; Region: Fimbrial; cl01416 476213005423 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 476213005424 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 476213005425 DNA binding site [nucleotide binding] 476213005426 active site 476213005427 Int/Topo IB signature motif; other site 476213005428 potential frameshift: common BLAST hit: gi|207856633|ref|YP_002243284.1| transposase 476213005429 Transposase, Mutator family; Region: Transposase_mut; cl19537 476213005430 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 476213005431 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 476213005432 Transposase, Mutator family; Region: Transposase_mut; cl19537 476213005433 Transposase, Mutator family; Region: Transposase_mut; cl19537 476213005434 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 476213005435 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 476213005436 Coenzyme A binding pocket [chemical binding]; other site 476213005437 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 476213005438 type III secretion protein SopE2; Provisional; Region: PRK15280 476213005439 SopE GEF domain; Region: SopE_GEF; pfam07487 476213005440 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 476213005441 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 476213005442 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 476213005443 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 476213005444 Methyltransferase domain; Region: Methyltransf_26; pfam13659 476213005445 Uncharacterized conserved protein [Function unknown]; Region: COG3270 476213005446 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 476213005447 mce related protein; Region: MCE; pfam02470 476213005448 mce related protein; Region: MCE; pfam02470 476213005449 mce related protein; Region: MCE; pfam02470 476213005450 mce related protein; Region: MCE; pfam02470 476213005451 mce related protein; Region: MCE; pfam02470 476213005452 mce related protein; Region: MCE; pfam02470 476213005453 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 476213005454 Paraquat-inducible protein A; Region: PqiA; pfam04403 476213005455 Paraquat-inducible protein A; Region: PqiA; pfam04403 476213005456 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 476213005457 ProP expression regulator; Provisional; Region: PRK04950 476213005458 putative RNA binding sites [nucleotide binding]; other site 476213005459 carboxy-terminal protease; Provisional; Region: PRK11186 476213005460 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 476213005461 protein binding site [polypeptide binding]; other site 476213005462 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 476213005463 Catalytic dyad [active] 476213005464 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 476213005465 heat shock protein HtpX; Provisional; Region: PRK05457 476213005466 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213005467 Major Facilitator Superfamily; Region: MFS_1; pfam07690 476213005468 putative substrate translocation pore; other site 476213005469 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 476213005470 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 476213005471 dimerization interface [polypeptide binding]; other site 476213005472 putative Zn2+ binding site [ion binding]; other site 476213005473 putative DNA binding site [nucleotide binding]; other site 476213005474 Bacterial transcriptional regulator; Region: IclR; pfam01614 476213005475 YobH-like protein; Region: YobH; pfam13996 476213005476 PhoPQ regulatory protein; Provisional; Region: PRK10299 476213005477 YebO-like protein; Region: YebO; pfam13974 476213005478 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 476213005479 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 476213005480 DNA-binding site [nucleotide binding]; DNA binding site 476213005481 RNA-binding motif; other site 476213005482 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 476213005483 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 476213005484 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 476213005485 hypothetical protein; Provisional; Region: PRK11469 476213005486 Domain of unknown function DUF; Region: DUF204; pfam02659 476213005487 Domain of unknown function DUF; Region: DUF204; pfam02659 476213005488 hypothetical protein; Provisional; Region: PRK02913 476213005489 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 476213005490 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 476213005491 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 476213005492 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 476213005493 active pocket/dimerization site; other site 476213005494 active site 476213005495 phosphorylation site [posttranslational modification] 476213005496 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 476213005497 active site 476213005498 phosphorylation site [posttranslational modification] 476213005499 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 476213005500 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 476213005501 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 476213005502 Transporter associated domain; Region: CorC_HlyC; smart01091 476213005503 phage resistance protein; Provisional; Region: PRK10551 476213005504 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 476213005505 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 476213005506 L-serine deaminase; Provisional; Region: PRK15023 476213005507 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 476213005508 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 476213005509 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 476213005510 putative active site [active] 476213005511 putative CoA binding site [chemical binding]; other site 476213005512 nudix motif; other site 476213005513 metal binding site [ion binding]; metal-binding site 476213005514 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 476213005515 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 476213005516 chorismate binding enzyme; Region: Chorismate_bind; cl10555 476213005517 hypothetical protein; Provisional; Region: PRK05114 476213005518 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 476213005519 homotrimer interaction site [polypeptide binding]; other site 476213005520 putative active site [active] 476213005521 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 476213005522 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708 476213005523 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 476213005524 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 476213005525 Glycoprotease family; Region: Peptidase_M22; pfam00814 476213005526 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 476213005527 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 476213005528 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 476213005529 acyl-activating enzyme (AAE) consensus motif; other site 476213005530 putative AMP binding site [chemical binding]; other site 476213005531 putative active site [active] 476213005532 putative CoA binding site [chemical binding]; other site 476213005533 ribonuclease D; Provisional; Region: PRK10829 476213005534 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 476213005535 catalytic site [active] 476213005536 putative active site [active] 476213005537 putative substrate binding site [chemical binding]; other site 476213005538 HRDC domain; Region: HRDC; cl02578 476213005539 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 476213005540 cell division inhibitor MinD; Provisional; Region: PRK10818 476213005541 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 476213005542 P-loop; other site 476213005543 ADP binding residues [chemical binding]; other site 476213005544 Switch I; other site 476213005545 Switch II; other site 476213005546 septum formation inhibitor; Reviewed; Region: minC; PRK03511 476213005547 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 476213005548 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 476213005549 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 476213005550 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 476213005551 hypothetical protein; Provisional; Region: PRK10691 476213005552 hypothetical protein; Provisional; Region: PRK05170 476213005553 GnsA/GnsB family; Region: GnsAB; pfam08178 476213005554 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 476213005555 disulfide bond formation protein B; Provisional; Region: PRK01749 476213005556 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 476213005557 fatty acid metabolism regulator; Provisional; Region: PRK04984 476213005558 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 476213005559 DNA-binding site [nucleotide binding]; DNA binding site 476213005560 FadR C-terminal domain; Region: FadR_C; pfam07840 476213005561 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 476213005562 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 476213005563 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 476213005564 alanine racemase; Reviewed; Region: dadX; PRK03646 476213005565 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 476213005566 active site 476213005567 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 476213005568 substrate binding site [chemical binding]; other site 476213005569 catalytic residues [active] 476213005570 dimer interface [polypeptide binding]; other site 476213005571 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 476213005572 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 476213005573 TrkA-C domain; Region: TrkA_C; pfam02080 476213005574 Transporter associated domain; Region: CorC_HlyC; smart01091 476213005575 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 476213005576 dimer interface [polypeptide binding]; other site 476213005577 catalytic triad [active] 476213005578 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 476213005579 N-acetyl-D-glucosamine binding site [chemical binding]; other site 476213005580 catalytic residue [active] 476213005581 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 476213005582 Flagellar regulator YcgR; Region: YcgR; pfam07317 476213005583 PilZ domain; Region: PilZ; pfam07238 476213005584 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 476213005585 trehalase; Provisional; Region: treA; PRK13271 476213005586 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 476213005587 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 476213005588 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 476213005589 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 476213005590 NAD(P) binding site [chemical binding]; other site 476213005591 hypothetical protein; Provisional; Region: PRK14749 476213005592 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 476213005593 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 476213005594 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 476213005595 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 476213005596 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 476213005597 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 476213005598 putative substrate-binding site; other site 476213005599 nickel binding site [ion binding]; other site 476213005600 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 476213005601 hydrogenase 1 large subunit; Provisional; Region: PRK10170 476213005602 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 476213005603 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 476213005604 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 476213005605 NiFe/NiFeSe hydrogenase small subunit C-terminal; Region: NiFe_hyd_SSU_C; pfam14720 476213005606 Protein of unknown function (DUF2743); Region: DUF2743; pfam10899 476213005607 Protein of unknown function (DUF4427); Region: DUF4427; pfam14468 476213005608 GTP-binding protein YchF; Reviewed; Region: PRK09601 476213005609 YchF GTPase; Region: YchF; cd01900 476213005610 G1 box; other site 476213005611 GTP/Mg2+ binding site [chemical binding]; other site 476213005612 Switch I region; other site 476213005613 G2 box; other site 476213005614 Switch II region; other site 476213005615 G3 box; other site 476213005616 G4 box; other site 476213005617 G5 box; other site 476213005618 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 476213005619 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 476213005620 putative active site [active] 476213005621 catalytic residue [active] 476213005622 hypothetical protein; Provisional; Region: PRK10692 476213005623 putative transporter; Provisional; Region: PRK11660 476213005624 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 476213005625 Sulfate transporter family; Region: Sulfate_transp; pfam00916 476213005626 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 476213005627 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 476213005628 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 476213005629 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 476213005630 active site 476213005631 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 476213005632 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 476213005633 Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017 476213005634 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 476213005635 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 476213005636 S-adenosylmethionine binding site [chemical binding]; other site 476213005637 hypothetical protein; Provisional; Region: PRK10278 476213005638 hypothetical protein; Provisional; Region: PRK10941 476213005639 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 476213005640 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 476213005641 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 476213005642 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 476213005643 cation transport regulator; Reviewed; Region: chaB; PRK09582 476213005644 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 476213005645 putative invasin; Provisional; Region: PRK10177 476213005646 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 476213005647 transcriptional regulator NarL; Provisional; Region: PRK10651 476213005648 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 476213005649 active site 476213005650 phosphorylation site [posttranslational modification] 476213005651 intermolecular recognition site; other site 476213005652 dimerization interface [polypeptide binding]; other site 476213005653 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 476213005654 DNA binding residues [nucleotide binding] 476213005655 dimerization interface [polypeptide binding]; other site 476213005656 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 476213005657 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 476213005658 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 476213005659 dimerization interface [polypeptide binding]; other site 476213005660 Histidine kinase; Region: HisKA_3; pfam07730 476213005661 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 476213005662 ATP binding site [chemical binding]; other site 476213005663 Mg2+ binding site [ion binding]; other site 476213005664 G-X-G motif; other site 476213005665 lysophospholipid transporter LplT; Provisional; Region: PRK11195; cl19150 476213005666 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 476213005667 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 476213005668 Respiratory nitrate reductase alpha N-terminal; Region: Nitr_red_alph_N; pfam14710 476213005669 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 476213005670 [4Fe-4S] binding site [ion binding]; other site 476213005671 molybdopterin cofactor binding site [chemical binding]; other site 476213005672 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 476213005673 molybdopterin cofactor binding site; other site 476213005674 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 476213005675 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 476213005676 Respiratory nitrate reductase beta C-terminal; Region: Nitr_red_bet_C; pfam14711 476213005677 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 476213005678 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 476213005679 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 476213005680 Sel1-like repeats; Region: SEL1; smart00671 476213005681 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 476213005682 Sel1-like repeats; Region: SEL1; smart00671 476213005683 Sel1-like repeats; Region: SEL1; smart00671 476213005684 Sel1-like repeats; Region: SEL1; smart00671 476213005685 Sel1-like repeats; Region: SEL1; smart00671 476213005686 Sel1-like repeats; Region: SEL1; smart00671 476213005687 Sel1-like repeats; Region: SEL1; smart00671 476213005688 Sel1-like repeats; Region: SEL1; smart00671 476213005689 Sel1-like repeats; Region: SEL1; smart00671 476213005690 Sel1-like repeats; Region: SEL1; smart00671 476213005691 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 476213005692 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 476213005693 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 476213005694 putative active site [active] 476213005695 putative substrate binding site [chemical binding]; other site 476213005696 putative cosubstrate binding site; other site 476213005697 catalytic site [active] 476213005698 hypothetical protein; Provisional; Region: PRK01617 476213005699 SEC-C motif; Region: SEC-C; cl19389 476213005700 SEC-C motif; Region: SEC-C; cl19389 476213005701 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 476213005702 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 476213005703 active site 476213005704 nucleophile elbow; other site 476213005705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 476213005706 active site 476213005707 response regulator of RpoS; Provisional; Region: PRK10693 476213005708 phosphorylation site [posttranslational modification] 476213005709 intermolecular recognition site; other site 476213005710 dimerization interface [polypeptide binding]; other site 476213005711 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 476213005712 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 476213005713 active site 476213005714 tetramer interface; other site 476213005715 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 476213005716 DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916 476213005717 thymidine kinase; Provisional; Region: PRK04296 476213005718 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 476213005719 Coenzyme A acylating aldehyde dehydrogenase (ACDH), Ethanolamine utilization protein EutE, and related proteins; Region: ALDH_F20_ACDH_EutE-like; cd07081 476213005720 putative catalytic cysteine [active] 476213005721 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 476213005722 putative active site [active] 476213005723 metal binding site [ion binding]; metal-binding site 476213005724 hypothetical protein; Provisional; Region: PRK11111 476213005725 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 476213005726 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 476213005727 peptide binding site [polypeptide binding]; other site 476213005728 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 476213005729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213005730 dimer interface [polypeptide binding]; other site 476213005731 conserved gate region; other site 476213005732 putative PBP binding loops; other site 476213005733 ABC-ATPase subunit interface; other site 476213005734 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 476213005735 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 476213005736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213005737 dimer interface [polypeptide binding]; other site 476213005738 conserved gate region; other site 476213005739 putative PBP binding loops; other site 476213005740 ABC-ATPase subunit interface; other site 476213005741 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 476213005742 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 476213005743 Walker A/P-loop; other site 476213005744 ATP binding site [chemical binding]; other site 476213005745 Q-loop/lid; other site 476213005746 ABC transporter signature motif; other site 476213005747 Walker B; other site 476213005748 D-loop; other site 476213005749 H-loop/switch region; other site 476213005750 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 476213005751 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 476213005752 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 476213005753 Walker A/P-loop; other site 476213005754 ATP binding site [chemical binding]; other site 476213005755 Q-loop/lid; other site 476213005756 ABC transporter signature motif; other site 476213005757 Walker B; other site 476213005758 D-loop; other site 476213005759 H-loop/switch region; other site 476213005760 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 476213005761 Ion transport protein; Region: Ion_trans; pfam00520 476213005762 Ion channel; Region: Ion_trans_2; pfam07885 476213005763 Double zinc ribbon; Region: DZR; pfam12773 476213005764 dsDNA-mimic protein; Reviewed; Region: PRK05094 476213005765 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 476213005766 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 476213005767 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 476213005768 putative active site [active] 476213005769 catalytic site [active] 476213005770 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 476213005771 putative active site [active] 476213005772 catalytic site [active] 476213005773 YciI-like protein; Reviewed; Region: PRK11370 476213005774 transport protein TonB; Provisional; Region: PRK10819 476213005775 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544 476213005776 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 476213005777 intracellular septation protein A; Reviewed; Region: PRK00259 476213005778 hypothetical protein; Provisional; Region: PRK02868 476213005779 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 476213005780 outer membrane protein W; Provisional; Region: PRK10959 476213005781 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 476213005782 dimanganese center [ion binding]; other site 476213005783 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 476213005784 dinuclear metal binding motif [ion binding]; other site 476213005785 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 476213005786 dimerization interface [polypeptide binding]; other site 476213005787 metal binding site [ion binding]; metal-binding site 476213005788 General stress protein [General function prediction only]; Region: GsiB; COG3729 476213005789 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 476213005790 substrate binding site [chemical binding]; other site 476213005791 active site 476213005792 catalytic residues [active] 476213005793 heterodimer interface [polypeptide binding]; other site 476213005794 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 476213005795 pyridoxal 5'-phosphate binding site [chemical binding]; other site 476213005796 catalytic residue [active] 476213005797 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 476213005798 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 476213005799 active site 476213005800 ribulose/triose binding site [chemical binding]; other site 476213005801 phosphate binding site [ion binding]; other site 476213005802 substrate (anthranilate) binding pocket [chemical binding]; other site 476213005803 product (indole) binding pocket [chemical binding]; other site 476213005804 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 476213005805 active site 476213005806 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 476213005807 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 476213005808 glutamine binding [chemical binding]; other site 476213005809 catalytic triad [active] 476213005810 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 476213005811 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 476213005812 anthranilate synthase component I; Provisional; Region: PRK13564 476213005813 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 476213005814 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 476213005815 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 476213005816 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 476213005817 active site 476213005818 hypothetical protein; Provisional; Region: PRK11630 476213005819 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 476213005820 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 476213005821 RNA binding surface [nucleotide binding]; other site 476213005822 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 476213005823 probable active site [active] 476213005824 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 476213005825 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 476213005826 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 476213005827 homodimer interface [polypeptide binding]; other site 476213005828 Walker A motif; other site 476213005829 ATP binding site [chemical binding]; other site 476213005830 hydroxycobalamin binding site [chemical binding]; other site 476213005831 Walker B motif; other site 476213005832 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 476213005833 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 476213005834 NADP binding site [chemical binding]; other site 476213005835 homodimer interface [polypeptide binding]; other site 476213005836 active site 476213005837 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 476213005838 putative inner membrane peptidase; Provisional; Region: PRK11778 476213005839 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 476213005840 tandem repeat interface [polypeptide binding]; other site 476213005841 oligomer interface [polypeptide binding]; other site 476213005842 active site residues [active] 476213005843 hypothetical protein; Provisional; Region: PRK11037 476213005844 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 476213005845 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 476213005846 active site 476213005847 interdomain interaction site; other site 476213005848 putative metal-binding site [ion binding]; other site 476213005849 nucleotide binding site [chemical binding]; other site 476213005850 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 476213005851 domain I; other site 476213005852 DNA binding groove [nucleotide binding] 476213005853 phosphate binding site [ion binding]; other site 476213005854 domain II; other site 476213005855 domain III; other site 476213005856 nucleotide binding site [chemical binding]; other site 476213005857 catalytic site [active] 476213005858 domain IV; other site 476213005859 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 476213005860 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 476213005861 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 476213005862 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 476213005863 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 476213005864 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213005865 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 476213005866 substrate binding site [chemical binding]; other site 476213005867 putative dimerization interface [polypeptide binding]; other site 476213005868 aconitate hydratase; Validated; Region: PRK09277 476213005869 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 476213005870 substrate binding site [chemical binding]; other site 476213005871 ligand binding site [chemical binding]; other site 476213005872 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 476213005873 substrate binding site [chemical binding]; other site 476213005874 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 476213005875 dimerization interface [polypeptide binding]; other site 476213005876 active site 476213005877 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 476213005878 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 476213005879 active site 476213005880 Predicted membrane protein [Function unknown]; Region: COG3771 476213005881 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 476213005882 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 476213005883 TPR motif; other site 476213005884 binding surface 476213005885 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 476213005886 binding surface 476213005887 TPR motif; other site 476213005888 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 476213005889 active site 476213005890 dimer interface [polypeptide binding]; other site 476213005891 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 476213005892 putative rRNA binding site [nucleotide binding]; other site 476213005893 lipoprotein; Provisional; Region: PRK10540 476213005894 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 476213005895 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 476213005896 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 476213005897 hypothetical protein; Provisional; Region: PRK13658 476213005898 RNase II stability modulator; Provisional; Region: PRK10060 476213005899 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 476213005900 putative active site [active] 476213005901 heme pocket [chemical binding]; other site 476213005902 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 476213005903 metal binding site [ion binding]; metal-binding site 476213005904 active site 476213005905 I-site; other site 476213005906 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 476213005907 exoribonuclease II; Provisional; Region: PRK05054 476213005908 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 476213005909 RNB domain; Region: RNB; pfam00773 476213005910 S1 RNA binding domain; Region: S1; pfam00575 476213005911 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 476213005912 Uncharacterized conserved protein [Function unknown]; Region: COG2128 476213005913 Uncharacterized conserved protein [Function unknown]; Region: COG2128 476213005914 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 476213005915 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 476213005916 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 476213005917 NAD binding site [chemical binding]; other site 476213005918 homotetramer interface [polypeptide binding]; other site 476213005919 homodimer interface [polypeptide binding]; other site 476213005920 substrate binding site [chemical binding]; other site 476213005921 active site 476213005922 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 476213005923 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 476213005924 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 476213005925 Walker A/P-loop; other site 476213005926 ATP binding site [chemical binding]; other site 476213005927 Q-loop/lid; other site 476213005928 ABC transporter signature motif; other site 476213005929 Walker B; other site 476213005930 D-loop; other site 476213005931 H-loop/switch region; other site 476213005932 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 476213005933 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 476213005934 Walker A/P-loop; other site 476213005935 ATP binding site [chemical binding]; other site 476213005936 Q-loop/lid; other site 476213005937 ABC transporter signature motif; other site 476213005938 Walker B; other site 476213005939 D-loop; other site 476213005940 H-loop/switch region; other site 476213005941 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 476213005942 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 476213005943 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 476213005944 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213005945 dimer interface [polypeptide binding]; other site 476213005946 conserved gate region; other site 476213005947 putative PBP binding loops; other site 476213005948 ABC-ATPase subunit interface; other site 476213005949 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapB; COG4168 476213005950 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213005951 dimer interface [polypeptide binding]; other site 476213005952 conserved gate region; other site 476213005953 putative PBP binding loops; other site 476213005954 ABC-ATPase subunit interface; other site 476213005955 antimicrobial peptide ABC transporter periplasmic binding protein SapA; Provisional; Region: PRK15109 476213005956 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 476213005957 peptide binding site [polypeptide binding]; other site 476213005958 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 476213005959 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 476213005960 Walker A motif; other site 476213005961 ATP binding site [chemical binding]; other site 476213005962 Walker B motif; other site 476213005963 arginine finger; other site 476213005964 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 476213005965 phage shock protein PspA; Provisional; Region: PRK10698 476213005966 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 476213005967 phage shock protein B; Provisional; Region: pspB; PRK09458 476213005968 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 476213005969 phage shock protein C; Region: phageshock_pspC; TIGR02978 476213005970 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 476213005971 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 476213005972 active site residue [active] 476213005973 Predicted ATPase [General function prediction only]; Region: COG3106 476213005974 hypothetical protein; Provisional; Region: PRK05415 476213005975 Predicted membrane protein [Function unknown]; Region: COG3768 476213005976 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 476213005977 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 476213005978 putative aromatic amino acid binding site; other site 476213005979 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 476213005980 putative active site [active] 476213005981 heme pocket [chemical binding]; other site 476213005982 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 476213005983 Walker A motif; other site 476213005984 ATP binding site [chemical binding]; other site 476213005985 Walker B motif; other site 476213005986 arginine finger; other site 476213005987 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 476213005988 dimer interface [polypeptide binding]; other site 476213005989 catalytic triad [active] 476213005990 peroxidatic and resolving cysteines [active] 476213005991 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 476213005992 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 476213005993 active site 476213005994 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 476213005995 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 476213005996 putative active site [active] 476213005997 Zn binding site [ion binding]; other site 476213005998 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 476213005999 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 476213006000 peptide binding site [polypeptide binding]; other site 476213006001 Transcriptional regulator [Transcription]; Region: LysR; COG0583 476213006002 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213006003 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 476213006004 putative effector binding pocket; other site 476213006005 putative dimerization interface [polypeptide binding]; other site 476213006006 oxidoreductase; Provisional; Region: PRK12742 476213006007 classical (c) SDRs; Region: SDR_c; cd05233 476213006008 NAD(P) binding site [chemical binding]; other site 476213006009 active site 476213006010 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 476213006011 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 476213006012 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 476213006013 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 476213006014 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213006015 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 476213006016 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 476213006017 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: Tpx; COG2077 476213006018 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 476213006019 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 476213006020 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 476213006021 non-specific DNA binding site [nucleotide binding]; other site 476213006022 salt bridge; other site 476213006023 sequence-specific DNA binding site [nucleotide binding]; other site 476213006024 Cupin domain; Region: Cupin_2; pfam07883 476213006025 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 476213006026 Mechanosensitive ion channel; Region: MS_channel; pfam00924 476213006027 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 476213006028 universal stress protein UspE; Provisional; Region: PRK11175 476213006029 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 476213006030 Ligand Binding Site [chemical binding]; other site 476213006031 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 476213006032 Ligand Binding Site [chemical binding]; other site 476213006033 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 476213006034 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 476213006035 ligand binding site [chemical binding]; other site 476213006036 flexible hinge region; other site 476213006037 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 476213006038 putative switch regulator; other site 476213006039 non-specific DNA interactions [nucleotide binding]; other site 476213006040 DNA binding site [nucleotide binding] 476213006041 sequence specific DNA binding site [nucleotide binding]; other site 476213006042 putative cAMP binding site [chemical binding]; other site 476213006043 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 476213006044 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 476213006045 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 476213006046 DNA binding site [nucleotide binding] 476213006047 active site 476213006048 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 476213006049 Smr domain; Region: Smr; pfam01713 476213006050 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 476213006051 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 476213006052 Cl binding site [ion binding]; other site 476213006053 oligomer interface [polypeptide binding]; other site 476213006054 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 476213006055 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 476213006056 ATP binding site [chemical binding]; other site 476213006057 Mg++ binding site [ion binding]; other site 476213006058 motif III; other site 476213006059 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 476213006060 nucleotide binding region [chemical binding]; other site 476213006061 ATP-binding site [chemical binding]; other site 476213006062 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 476213006063 putative RNA binding site [nucleotide binding]; other site 476213006064 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 476213006065 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 476213006066 Ligand Binding Site [chemical binding]; other site 476213006067 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 476213006068 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 476213006069 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 476213006070 Ligand Binding Site [chemical binding]; other site 476213006071 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 476213006072 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 476213006073 dimer interface [polypeptide binding]; other site 476213006074 PYR/PP interface [polypeptide binding]; other site 476213006075 TPP binding site [chemical binding]; other site 476213006076 substrate binding site [chemical binding]; other site 476213006077 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 476213006078 Domain of unknown function; Region: EKR; pfam10371 476213006079 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 476213006080 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 476213006081 TPP-binding site [chemical binding]; other site 476213006082 dimer interface [polypeptide binding]; other site 476213006083 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 476213006084 heat-inducible protein; Provisional; Region: PRK10449 476213006085 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 476213006086 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 476213006087 putative ligand binding site [chemical binding]; other site 476213006088 putative NAD binding site [chemical binding]; other site 476213006089 catalytic site [active] 476213006090 hypothetical protein; Provisional; Region: PRK10695 476213006091 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 476213006092 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 476213006093 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 476213006094 azoreductase; Reviewed; Region: PRK00170 476213006095 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 476213006096 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 476213006097 ATP binding site [chemical binding]; other site 476213006098 putative Mg++ binding site [ion binding]; other site 476213006099 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 476213006100 nucleotide binding region [chemical binding]; other site 476213006101 ATP-binding site [chemical binding]; other site 476213006102 Helicase associated domain (HA2); Region: HA2; pfam04408 476213006103 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 476213006104 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 476213006105 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 476213006106 putative active site [active] 476213006107 cytochrome b561; Provisional; Region: PRK11513 476213006108 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 476213006109 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 476213006110 S-adenosylmethionine binding site [chemical binding]; other site 476213006111 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 476213006112 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213006113 dimer interface [polypeptide binding]; other site 476213006114 conserved gate region; other site 476213006115 putative PBP binding loops; other site 476213006116 ABC-ATPase subunit interface; other site 476213006117 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 476213006118 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 476213006119 Walker A/P-loop; other site 476213006120 ATP binding site [chemical binding]; other site 476213006121 Q-loop/lid; other site 476213006122 ABC transporter signature motif; other site 476213006123 Walker B; other site 476213006124 D-loop; other site 476213006125 H-loop/switch region; other site 476213006126 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 476213006127 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213006128 dimer interface [polypeptide binding]; other site 476213006129 conserved gate region; other site 476213006130 putative PBP binding loops; other site 476213006131 ABC-ATPase subunit interface; other site 476213006132 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 476213006133 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 476213006134 substrate binding pocket [chemical binding]; other site 476213006135 membrane-bound complex binding site; other site 476213006136 hinge residues; other site 476213006137 Predicted membrane protein [Function unknown]; Region: COG3326 476213006138 Sif protein; Region: Sif; cl11505 476213006139 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 476213006140 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 476213006141 active site 476213006142 catalytic triad [active] 476213006143 oxyanion hole [active] 476213006144 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 476213006145 putative metal binding site [ion binding]; other site 476213006146 putative homodimer interface [polypeptide binding]; other site 476213006147 putative homotetramer interface [polypeptide binding]; other site 476213006148 putative homodimer-homodimer interface [polypeptide binding]; other site 476213006149 putative allosteric switch controlling residues; other site 476213006150 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 476213006151 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 476213006152 substrate binding site [chemical binding]; other site 476213006153 catalytic Zn binding site [ion binding]; other site 476213006154 NAD binding site [chemical binding]; other site 476213006155 structural Zn binding site [ion binding]; other site 476213006156 dimer interface [polypeptide binding]; other site 476213006157 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 476213006158 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 476213006159 dimer interface [polypeptide binding]; other site 476213006160 ligand binding site [chemical binding]; other site 476213006161 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 476213006162 dimerization interface [polypeptide binding]; other site 476213006163 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 476213006164 dimer interface [polypeptide binding]; other site 476213006165 putative CheW interface [polypeptide binding]; other site 476213006166 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 476213006167 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213006168 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 476213006169 dimerization interface [polypeptide binding]; other site 476213006170 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 476213006171 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 476213006172 substrate binding pocket [chemical binding]; other site 476213006173 catalytic triad [active] 476213006174 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 476213006175 Uncharacterized conserved protein [Function unknown]; Region: COG2353 476213006176 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 476213006177 teramer interface [polypeptide binding]; other site 476213006178 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 476213006179 active site 476213006180 FMN binding site [chemical binding]; other site 476213006181 catalytic residues [active] 476213006182 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 476213006183 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 476213006184 Coenzyme A binding pocket [chemical binding]; other site 476213006185 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 476213006186 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 476213006187 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 476213006188 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 476213006189 substrate binding site [chemical binding]; other site 476213006190 hexamer interface [polypeptide binding]; other site 476213006191 metal binding site [ion binding]; metal-binding site 476213006192 active site 476213006193 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762 476213006194 phosphorylation site [posttranslational modification] 476213006195 membrane complex biogenesis protein, BtpA family; Region: thylakoid_BtpA; TIGR00259 476213006196 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 476213006197 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 476213006198 active site 476213006199 P-loop; other site 476213006200 phosphorylation site [posttranslational modification] 476213006201 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 476213006202 oligomer interface [polypeptide binding]; other site 476213006203 active site 476213006204 metal binding site [ion binding]; metal-binding site 476213006205 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 476213006206 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 476213006207 Coenzyme A binding pocket [chemical binding]; other site 476213006208 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 476213006209 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 476213006210 putative trimer interface [polypeptide binding]; other site 476213006211 putative CoA binding site [chemical binding]; other site 476213006212 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 476213006213 putative trimer interface [polypeptide binding]; other site 476213006214 putative CoA binding site [chemical binding]; other site 476213006215 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 476213006216 gating phenylalanine in ion channel; other site 476213006217 tellurite resistance protein TehB; Provisional; Region: PRK11207 476213006218 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 476213006219 S-adenosylmethionine binding site [chemical binding]; other site 476213006220 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 476213006221 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 476213006222 benzoate transporter; Region: benE; TIGR00843 476213006223 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 476213006224 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 476213006225 non-specific DNA binding site [nucleotide binding]; other site 476213006226 salt bridge; other site 476213006227 sequence-specific DNA binding site [nucleotide binding]; other site 476213006228 Cupin domain; Region: Cupin_2; pfam07883 476213006229 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 476213006230 Collagenase; Region: DUF3656; pfam12392 476213006231 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 476213006232 secreted effector protein SifB; Provisional; Region: sifB; PRK09499 476213006233 D-alanyl-D-alanine dipeptidase [Cell envelope biogenesis, outer membrane]; Region: DdpX; COG2173 476213006234 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 476213006235 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 476213006236 DNA-binding site [nucleotide binding]; DNA binding site 476213006237 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 476213006238 pyridoxal 5'-phosphate binding site [chemical binding]; other site 476213006239 homodimer interface [polypeptide binding]; other site 476213006240 catalytic residue [active] 476213006241 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 476213006242 tetrameric interface [polypeptide binding]; other site 476213006243 NAD binding site [chemical binding]; other site 476213006244 catalytic residues [active] 476213006245 substrate binding site [chemical binding]; other site 476213006246 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 476213006247 Putative bacterial virulence factor; Region: Virul_Fac; cl19867 476213006248 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfB; COG4457 476213006249 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 476213006250 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 476213006251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 476213006252 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 476213006253 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 476213006254 Coenzyme A binding pocket [chemical binding]; other site 476213006255 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 476213006256 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 476213006257 N-terminal plug; other site 476213006258 ligand-binding site [chemical binding]; other site 476213006259 Uncharacterized conserved protein [Function unknown]; Region: COG3391 476213006260 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 476213006261 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 476213006262 L-asparagine permease; Provisional; Region: PRK15049 476213006263 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 476213006264 hypothetical protein; Provisional; Region: PRK10281 476213006265 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 476213006266 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 476213006267 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 476213006268 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 476213006269 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 476213006270 Respiratory nitrate reductase beta C-terminal; Region: Nitr_red_bet_C; pfam14711 476213006271 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 476213006272 Respiratory nitrate reductase alpha N-terminal; Region: Nitr_red_alph_N; pfam14710 476213006273 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 476213006274 [4Fe-4S] binding site [ion binding]; other site 476213006275 molybdopterin cofactor binding site [chemical binding]; other site 476213006276 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 476213006277 molybdopterin cofactor binding site; other site 476213006278 TetR family transcriptional regulator; Provisional; Region: PRK14996 476213006279 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 476213006280 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 476213006281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213006282 putative substrate translocation pore; other site 476213006283 Uncharacterized conserved protein [Function unknown]; Region: COG3791 476213006284 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 476213006285 trimer interface [polypeptide binding]; other site 476213006286 eyelet of channel; other site 476213006287 aromatic amino acid exporter; Provisional; Region: PRK11689 476213006288 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 476213006289 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 476213006290 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 476213006291 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 476213006292 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 476213006293 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 476213006294 NAD binding site [chemical binding]; other site 476213006295 substrate binding site [chemical binding]; other site 476213006296 catalytic Zn binding site [ion binding]; other site 476213006297 tetramer interface [polypeptide binding]; other site 476213006298 structural Zn binding site [ion binding]; other site 476213006299 malate dehydrogenase; Provisional; Region: PRK13529 476213006300 Malic enzyme, N-terminal domain; Region: malic; pfam00390 476213006301 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 476213006302 NAD(P) binding site [chemical binding]; other site 476213006303 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 476213006304 biofilm-dependent modulation protein; Provisional; Region: PRK11436 476213006305 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 476213006306 acid-resistance protein; Provisional; Region: hdeB; PRK11566 476213006307 Protein of unknown function (DUF1264); Region: DUF1264; pfam06884 476213006308 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 476213006309 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 476213006310 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 476213006311 catalytic site [active] 476213006312 active site 476213006313 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 476213006314 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 476213006315 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 476213006316 active site 476213006317 catalytic site [active] 476213006318 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 476213006319 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 476213006320 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 476213006321 active site 476213006322 catalytic site [active] 476213006323 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 476213006324 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 476213006325 pyridoxal 5'-phosphate binding site [chemical binding]; other site 476213006326 homodimer interface [polypeptide binding]; other site 476213006327 catalytic residue [active] 476213006328 Transcriptional regulators [Transcription]; Region: PurR; COG1609 476213006329 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 476213006330 DNA binding site [nucleotide binding] 476213006331 domain linker motif; other site 476213006332 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 476213006333 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 476213006334 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 476213006335 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 476213006336 active site 476213006337 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 476213006338 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 476213006339 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 476213006340 NiFe/NiFeSe hydrogenase small subunit C-terminal; Region: NiFe_hyd_SSU_C; pfam14720 476213006341 hydrogenase 1 large subunit; Provisional; Region: PRK10170 476213006342 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 476213006343 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 476213006344 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 476213006345 putative substrate-binding site; other site 476213006346 nickel binding site [ion binding]; other site 476213006347 HupF/HypC family; Region: HupF_HypC; cl00394 476213006348 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 476213006349 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 476213006350 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 476213006351 Rubredoxin [Energy production and conversion]; Region: COG1773 476213006352 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 476213006353 iron binding site [ion binding]; other site 476213006354 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl19174 476213006355 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 476213006356 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 476213006357 trimer interface [polypeptide binding]; other site 476213006358 eyelet of channel; other site 476213006359 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 476213006360 Predicted membrane protein [Function unknown]; Region: COG3781 476213006361 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 476213006362 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 476213006363 NAD(P) binding site [chemical binding]; other site 476213006364 catalytic residues [active] 476213006365 Transcriptional regulator [Transcription]; Region: LysR; COG0583 476213006366 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213006367 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 476213006368 putative dimerization interface [polypeptide binding]; other site 476213006369 putative arabinose transporter; Provisional; Region: PRK03545 476213006370 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213006371 putative substrate translocation pore; other site 476213006372 inner membrane protein; Provisional; Region: PRK10995 476213006373 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 476213006374 Transcriptional regulators [Transcription]; Region: MarR; COG1846 476213006375 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 476213006376 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213006377 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213006378 MarB protein; Region: MarB; pfam13999 476213006379 putative transporter; Provisional; Region: PRK10054 476213006380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213006381 putative substrate translocation pore; other site 476213006382 hypothetical protein; Provisional; Region: PRK10053 476213006383 hypothetical protein; Validated; Region: PRK03657 476213006384 General stress protein [General function prediction only]; Region: GsiB; COG3729 476213006385 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 476213006386 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 476213006387 active site 476213006388 Zn binding site [ion binding]; other site 476213006389 malonic semialdehyde reductase; Provisional; Region: PRK10538 476213006390 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 476213006391 putative NAD(P) binding site [chemical binding]; other site 476213006392 homodimer interface [polypeptide binding]; other site 476213006393 homotetramer interface [polypeptide binding]; other site 476213006394 active site 476213006395 Transcriptional regulators [Transcription]; Region: GntR; COG1802 476213006396 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 476213006397 DNA-binding site [nucleotide binding]; DNA binding site 476213006398 FCD domain; Region: FCD; pfam07729 476213006399 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 476213006400 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 476213006401 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 476213006402 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 476213006403 putative oxidoreductase; Provisional; Region: PRK10083 476213006404 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 476213006405 putative NAD(P) binding site [chemical binding]; other site 476213006406 catalytic Zn binding site [ion binding]; other site 476213006407 structural Zn binding site [ion binding]; other site 476213006408 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 476213006409 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 476213006410 putative active site pocket [active] 476213006411 putative metal binding site [ion binding]; other site 476213006412 hypothetical protein; Provisional; Region: PRK02237 476213006413 hypothetical protein; Provisional; Region: PRK13659 476213006414 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 476213006415 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 476213006416 Coenzyme A binding pocket [chemical binding]; other site 476213006417 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 476213006418 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 476213006419 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 476213006420 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 476213006421 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 476213006422 putative [Fe4-S4] binding site [ion binding]; other site 476213006423 putative molybdopterin cofactor binding site [chemical binding]; other site 476213006424 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 476213006425 putative molybdopterin cofactor binding site; other site 476213006426 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 476213006427 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 476213006428 putative [Fe4-S4] binding site [ion binding]; other site 476213006429 putative molybdopterin cofactor binding site [chemical binding]; other site 476213006430 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 476213006431 putative molybdopterin cofactor binding site; other site 476213006432 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 476213006433 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 476213006434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213006435 dimer interface [polypeptide binding]; other site 476213006436 conserved gate region; other site 476213006437 putative PBP binding loops; other site 476213006438 ABC-ATPase subunit interface; other site 476213006439 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 476213006440 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213006441 dimer interface [polypeptide binding]; other site 476213006442 conserved gate region; other site 476213006443 putative PBP binding loops; other site 476213006444 ABC-ATPase subunit interface; other site 476213006445 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 476213006446 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 476213006447 Walker A/P-loop; other site 476213006448 ATP binding site [chemical binding]; other site 476213006449 Q-loop/lid; other site 476213006450 ABC transporter signature motif; other site 476213006451 Walker B; other site 476213006452 D-loop; other site 476213006453 H-loop/switch region; other site 476213006454 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 476213006455 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 476213006456 Cl- selectivity filter; other site 476213006457 Cl- binding residues [ion binding]; other site 476213006458 pore gating glutamate residue; other site 476213006459 dimer interface [polypeptide binding]; other site 476213006460 putative dithiobiotin synthetase; Provisional; Region: PRK12374 476213006461 AAA domain; Region: AAA_26; pfam13500 476213006462 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 476213006463 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 476213006464 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 476213006465 nucleotide binding site [chemical binding]; other site 476213006466 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 476213006467 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 476213006468 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213006469 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 476213006470 dimerization interface [polypeptide binding]; other site 476213006471 substrate binding pocket [chemical binding]; other site 476213006472 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 476213006473 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213006474 putative substrate translocation pore; other site 476213006475 acid shock protein precursor; Provisional; Region: PRK03577 476213006476 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 476213006477 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 476213006478 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 476213006479 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 476213006480 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 476213006481 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 476213006482 ligand binding site [chemical binding]; other site 476213006483 homodimer interface [polypeptide binding]; other site 476213006484 NAD(P) binding site [chemical binding]; other site 476213006485 trimer interface B [polypeptide binding]; other site 476213006486 trimer interface A [polypeptide binding]; other site 476213006487 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 476213006488 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 476213006489 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 476213006490 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 476213006491 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 476213006492 Spore germination protein; Region: Spore_permease; cl17796 476213006493 GlpM protein; Region: GlpM; pfam06942 476213006494 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 476213006495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 476213006496 active site 476213006497 phosphorylation site [posttranslational modification] 476213006498 intermolecular recognition site; other site 476213006499 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 476213006500 DNA binding site [nucleotide binding] 476213006501 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 476213006502 trimer interface [polypeptide binding]; other site 476213006503 eyelet of channel; other site 476213006504 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 476213006505 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 476213006506 active site 476213006507 sensor protein RstB; Provisional; Region: PRK10604 476213006508 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 476213006509 dimerization interface [polypeptide binding]; other site 476213006510 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 476213006511 dimer interface [polypeptide binding]; other site 476213006512 phosphorylation site [posttranslational modification] 476213006513 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 476213006514 ATP binding site [chemical binding]; other site 476213006515 Mg2+ binding site [ion binding]; other site 476213006516 G-X-G motif; other site 476213006517 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 476213006518 fumarate hydratase; Reviewed; Region: fumC; PRK00485 476213006519 Class II fumarases; Region: Fumarase_classII; cd01362 476213006520 active site 476213006521 tetramer interface [polypeptide binding]; other site 476213006522 fumarate hydratase; Provisional; Region: PRK15389 476213006523 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 476213006524 Fumarase C-terminus; Region: Fumerase_C; pfam05683 476213006525 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 476213006526 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 476213006527 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 476213006528 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 476213006529 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 476213006530 active site 476213006531 purine riboside binding site [chemical binding]; other site 476213006532 putative oxidoreductase; Provisional; Region: PRK11579 476213006533 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 476213006534 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 476213006535 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 476213006536 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 476213006537 electron transport complex protein RsxA; Provisional; Region: PRK05151 476213006538 electron transport complex protein RnfB; Provisional; Region: PRK05113 476213006539 Putative Fe-S cluster; Region: FeS; cl17515 476213006540 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 476213006541 electron transport complex protein RnfC; Provisional; Region: PRK05035 476213006542 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 476213006543 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 476213006544 SLBB domain; Region: SLBB; pfam10531 476213006545 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 476213006546 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 476213006547 electron transport complex protein RnfG; Validated; Region: PRK01908 476213006548 electron transport complex RsxE subunit; Provisional; Region: PRK12405 476213006549 endonuclease III; Provisional; Region: PRK10702 476213006550 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 476213006551 minor groove reading motif; other site 476213006552 helix-hairpin-helix signature motif; other site 476213006553 substrate binding pocket [chemical binding]; other site 476213006554 active site 476213006555 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 476213006556 putative tripeptide transporter permease; Reviewed; Region: tppB; PRK09584 476213006557 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 476213006558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213006559 putative substrate translocation pore; other site 476213006560 glutathionine S-transferase; Provisional; Region: PRK10542 476213006561 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 476213006562 C-terminal domain interface [polypeptide binding]; other site 476213006563 GSH binding site (G-site) [chemical binding]; other site 476213006564 dimer interface [polypeptide binding]; other site 476213006565 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 476213006566 dimer interface [polypeptide binding]; other site 476213006567 N-terminal domain interface [polypeptide binding]; other site 476213006568 substrate binding pocket (H-site) [chemical binding]; other site 476213006569 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 476213006570 dimer interface [polypeptide binding]; other site 476213006571 pyridoxal binding site [chemical binding]; other site 476213006572 ATP binding site [chemical binding]; other site 476213006573 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 476213006574 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 476213006575 active site 476213006576 HIGH motif; other site 476213006577 dimer interface [polypeptide binding]; other site 476213006578 KMSKS motif; other site 476213006579 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 476213006580 RNA binding surface [nucleotide binding]; other site 476213006581 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 476213006582 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 476213006583 Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590 476213006584 lysozyme inhibitor; Provisional; Region: PRK11372 476213006585 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 476213006586 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 476213006587 transcriptional regulator SlyA; Provisional; Region: PRK03573 476213006588 Transcriptional regulators [Transcription]; Region: MarR; COG1846 476213006589 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 476213006590 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 476213006591 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 476213006592 HlyD family secretion protein; Region: HlyD_3; pfam13437 476213006593 Fusaric acid resistance protein family; Region: FUSC; pfam04632 476213006594 Fusaric acid resistance protein-like; Region: FUSC_2; cl19401 476213006595 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 476213006596 E-class dimer interface [polypeptide binding]; other site 476213006597 P-class dimer interface [polypeptide binding]; other site 476213006598 active site 476213006599 Cu2+ binding site [ion binding]; other site 476213006600 Zn2+ binding site [ion binding]; other site 476213006601 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 476213006602 active site 476213006603 catalytic tetrad [active] 476213006604 Predicted Fe-S protein [General function prediction only]; Region: COG3313 476213006605 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 476213006606 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 476213006607 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 476213006608 FMN binding site [chemical binding]; other site 476213006609 active site 476213006610 substrate binding site [chemical binding]; other site 476213006611 catalytic residue [active] 476213006612 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 476213006613 dimer interface [polypeptide binding]; other site 476213006614 active site 476213006615 metal binding site [ion binding]; metal-binding site 476213006616 glutathione binding site [chemical binding]; other site 476213006617 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 476213006618 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 476213006619 dimer interface [polypeptide binding]; other site 476213006620 catalytic site [active] 476213006621 putative active site [active] 476213006622 putative substrate binding site [chemical binding]; other site 476213006623 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 476213006624 putative GSH binding site [chemical binding]; other site 476213006625 catalytic residues [active] 476213006626 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 476213006627 NlpC/P60 family; Region: NLPC_P60; pfam00877 476213006628 superoxide dismutase; Provisional; Region: PRK10543 476213006629 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 476213006630 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 476213006631 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 476213006632 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 476213006633 DNA binding site [nucleotide binding] 476213006634 domain linker motif; other site 476213006635 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 476213006636 dimerization interface [polypeptide binding]; other site 476213006637 ligand binding site [chemical binding]; other site 476213006638 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 476213006639 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213006640 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 476213006641 dimerization interface [polypeptide binding]; other site 476213006642 putative transporter; Provisional; Region: PRK11043 476213006643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213006644 putative substrate translocation pore; other site 476213006645 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 476213006646 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 476213006647 S-adenosylmethionine binding site [chemical binding]; other site 476213006648 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 476213006649 Lumazine binding domain; Region: Lum_binding; pfam00677 476213006650 Lumazine binding domain; Region: Lum_binding; pfam00677 476213006651 multidrug efflux protein; Reviewed; Region: PRK01766 476213006652 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 476213006653 cation binding site [ion binding]; other site 476213006654 secretion system apparatus protein SsaU; Reviewed; Region: PRK12721 476213006655 type III secretion system protein SsaT; Provisional; Region: PRK15349 476213006656 type III secretion system protein SsaS; Provisional; Region: PRK15350 476213006657 Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790 476213006658 type III secretion system protein SsaQ; Validated; Region: PRK08035 476213006659 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 476213006660 type III secretion system protein SsaP; Provisional; Region: PRK15351 476213006661 type III secretion system protein SsaO; Provisional; Region: PRK15352 476213006662 type III secretion system ATPase SsaN; Validated; Region: PRK07594 476213006663 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 476213006664 Walker A motif/ATP binding site; other site 476213006665 Walker B motif; other site 476213006666 secretion system apparatus protein SsaV; Provisional; Region: PRK12720 476213006667 type III secretion system protein SsaM; Provisional; Region: PRK15353 476213006668 type III secretion system protein SsaL; Provisional; Region: PRK15345 476213006669 HrpJ-like domain; Region: HrpJ; pfam07201 476213006670 TyeA; Region: TyeA; cl07611 476213006671 type III secretion system protein SsaK; Provisional; Region: PRK15354 476213006672 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 476213006673 Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327 476213006674 type III secretion system lipoprotein SsaJ; Provisional; Region: PRK15348 476213006675 type III secretion system protein SsaI; Provisional; Region: PRK15355 476213006676 type III secretion system protein SsaH; Provisional; Region: PRK15356 476213006677 type III secretion system needle protein SsaG; Provisional; Region: PRK15344 476213006678 pathogenicity island 2 effector protein SseG; Provisional; Region: PRK15357 476213006679 pathogenicity island 2 effector protein SseF; Provisional; Region: PRK15358 476213006680 type III secretion system chaperone protein SscB; Provisional; Region: PRK15359 476213006681 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 476213006682 TPR motif; other site 476213006683 binding surface 476213006684 pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360 476213006685 pathogenicity island 2 effector protein SseD; Provisional; Region: PRK15361 476213006686 pathogenicity island 2 effector protein SseC; Provisional; Region: PRK15362 476213006687 Secretion system effector C (SseC) like family; Region: SseC; pfam04888 476213006688 pathogenicity island 2 chaperone protein SscA; Provisional; Region: PRK15363 476213006689 pathogenicity island 2 effector protein SseB; Provisional; Region: PRK15364 476213006690 type III secretion system chaperone SseA; Provisional; Region: PRK15365 476213006691 type III secretion system chaperone SsaE; Provisional; Region: PRK15366 476213006692 type III secretion system protein SsaD; Provisional; Region: PRK15367 476213006693 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 476213006694 outer membrane secretin SsaC; Provisional; Region: PRK15346 476213006695 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 476213006696 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 476213006697 pathogenicity island chaperone protein SpiC; Provisional; Region: PRK15368 476213006698 two component system sensor kinase SsrA; Provisional; Region: PRK15347 476213006699 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 476213006700 dimerization interface [polypeptide binding]; other site 476213006701 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 476213006702 dimer interface [polypeptide binding]; other site 476213006703 phosphorylation site [posttranslational modification] 476213006704 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 476213006705 ATP binding site [chemical binding]; other site 476213006706 Mg2+ binding site [ion binding]; other site 476213006707 G-X-G motif; other site 476213006708 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 476213006709 active site 476213006710 phosphorylation site [posttranslational modification] 476213006711 intermolecular recognition site; other site 476213006712 dimerization interface [polypeptide binding]; other site 476213006713 two component system sensor kinase SsrB; Provisional; Region: PRK15369 476213006714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 476213006715 active site 476213006716 phosphorylation site [posttranslational modification] 476213006717 intermolecular recognition site; other site 476213006718 dimerization interface [polypeptide binding]; other site 476213006719 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 476213006720 DNA binding residues [nucleotide binding] 476213006721 dimerization interface [polypeptide binding]; other site 476213006722 transcriptional regulator MirA; Provisional; Region: PRK15043 476213006723 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 476213006724 DNA binding residues [nucleotide binding] 476213006725 Uncharacterized conserved protein [Function unknown]; Region: COG1683 476213006726 Uncharacterized conserved protein [Function unknown]; Region: COG3272 476213006727 hypothetical protein; Provisional; Region: PRK10292 476213006728 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 476213006729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 476213006730 active site 476213006731 phosphorylation site [posttranslational modification] 476213006732 intermolecular recognition site; other site 476213006733 dimerization interface [polypeptide binding]; other site 476213006734 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 476213006735 DNA binding residues [nucleotide binding] 476213006736 dimerization interface [polypeptide binding]; other site 476213006737 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 476213006738 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 476213006739 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 476213006740 dimer interface [polypeptide binding]; other site 476213006741 phosphorylation site [posttranslational modification] 476213006742 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 476213006743 ATP binding site [chemical binding]; other site 476213006744 Mg2+ binding site [ion binding]; other site 476213006745 G-X-G motif; other site 476213006746 tetrathionate reductase subunit B; Provisional; Region: PRK14993 476213006747 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 476213006748 tetrathionate reductase subunit C; Provisional; Region: PRK14992 476213006749 tetrathionate reductase subunit A; Provisional; Region: PRK14991 476213006750 The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758 476213006751 putative [Fe4-S4] binding site [ion binding]; other site 476213006752 putative molybdopterin cofactor binding site [chemical binding]; other site 476213006753 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 476213006754 putative molybdopterin cofactor binding site; other site 476213006755 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 476213006756 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 476213006757 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 476213006758 substrate binding site [chemical binding]; other site 476213006759 dimer interface [polypeptide binding]; other site 476213006760 ATP binding site [chemical binding]; other site 476213006761 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 476213006762 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 476213006763 Putative lysophospholipase; Region: Hydrolase_4; cl19140 476213006764 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 476213006765 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 476213006766 pyruvate kinase; Provisional; Region: PRK09206 476213006767 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 476213006768 domain interfaces; other site 476213006769 active site 476213006770 murein lipoprotein; Provisional; Region: PRK15396 476213006771 L,D-transpeptidase; Provisional; Region: PRK10260 476213006772 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 476213006773 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 476213006774 Fe-S metabolizm associated domain; Region: SufE; cl00951 476213006775 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 476213006776 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 476213006777 catalytic residue [active] 476213006778 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 476213006779 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 476213006780 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 476213006781 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 476213006782 Walker A/P-loop; other site 476213006783 ATP binding site [chemical binding]; other site 476213006784 Q-loop/lid; other site 476213006785 ABC transporter signature motif; other site 476213006786 Walker B; other site 476213006787 D-loop; other site 476213006788 H-loop/switch region; other site 476213006789 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 476213006790 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 476213006791 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 476213006792 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 476213006793 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 476213006794 CoenzymeA binding site [chemical binding]; other site 476213006795 subunit interaction site [polypeptide binding]; other site 476213006796 PHB binding site; other site 476213006797 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 476213006798 FAD binding domain; Region: FAD_binding_4; pfam01565 476213006799 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 476213006800 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 476213006801 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 476213006802 putative inner membrane protein; Provisional; Region: PRK10983 476213006803 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 476213006804 Helix-turn-helix domain; Region: HTH_28; pfam13518 476213006805 Integrase core domain; Region: rve; pfam00665 476213006806 Integrase core domain; Region: rve_3; pfam13683 476213006807 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 476213006808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213006809 Major Facilitator Superfamily; Region: MFS_1; pfam07690 476213006810 putative substrate translocation pore; other site 476213006811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213006812 putative substrate translocation pore; other site 476213006813 Major Facilitator Superfamily; Region: MFS_1; pfam07690 476213006814 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 476213006815 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 476213006816 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 476213006817 shikimate binding site; other site 476213006818 NAD(P) binding site [chemical binding]; other site 476213006819 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 476213006820 active site 476213006821 catalytic residue [active] 476213006822 dimer interface [polypeptide binding]; other site 476213006823 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 476213006824 Coenzyme A transferase; Region: CoA_trans; smart00882 476213006825 Coenzyme A transferase; Region: CoA_trans; cl17247 476213006826 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 476213006827 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 476213006828 active site 476213006829 Cupin domain; Region: Cupin_2; pfam07883 476213006830 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 476213006831 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 476213006832 Ligand binding site [chemical binding]; other site 476213006833 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 476213006834 Electron transfer flavoprotein domain; Region: ETF; pfam01012 476213006835 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 476213006836 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 476213006837 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 476213006838 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 476213006839 acyl-activating enzyme (AAE) consensus motif; other site 476213006840 putative AMP binding site [chemical binding]; other site 476213006841 putative active site [active] 476213006842 putative CoA binding site [chemical binding]; other site 476213006843 phosphoenolpyruvate synthase; Validated; Region: PRK06464 476213006844 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 476213006845 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 476213006846 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 476213006847 PEP synthetase regulatory protein; Provisional; Region: PRK05339 476213006848 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 476213006849 hypothetical protein; Provisional; Region: PRK10183 476213006850 hypothetical protein; Validated; Region: PRK00029 476213006851 NlpC/P60 family; Region: NLPC_P60; pfam00877 476213006852 ABC-type cobalamin transport system, ATPase component [Coenzyme metabolism]; Region: BtuD; COG4138 476213006853 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 476213006854 Walker A/P-loop; other site 476213006855 ATP binding site [chemical binding]; other site 476213006856 Q-loop/lid; other site 476213006857 ABC transporter signature motif; other site 476213006858 Walker B; other site 476213006859 D-loop; other site 476213006860 H-loop/switch region; other site 476213006861 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 476213006862 catalytic residues [active] 476213006863 dimer interface [polypeptide binding]; other site 476213006864 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 476213006865 ABC-ATPase subunit interface; other site 476213006866 dimer interface [polypeptide binding]; other site 476213006867 putative PBP binding regions; other site 476213006868 Alpha subunit of integration host factor (IHFA); Region: IHF_A; cd13835 476213006869 DNA binding site [nucleotide binding] 476213006870 dimer interface [polypeptide binding]; other site 476213006871 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 476213006872 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 476213006873 putative tRNA-binding site [nucleotide binding]; other site 476213006874 B3/4 domain; Region: B3_4; pfam03483 476213006875 tRNA synthetase B5 domain; Region: B5; smart00874 476213006876 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 476213006877 dimer interface [polypeptide binding]; other site 476213006878 motif 1; other site 476213006879 motif 3; other site 476213006880 motif 2; other site 476213006881 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 476213006882 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 476213006883 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 476213006884 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 476213006885 dimer interface [polypeptide binding]; other site 476213006886 motif 1; other site 476213006887 active site 476213006888 motif 2; other site 476213006889 motif 3; other site 476213006890 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 476213006891 23S rRNA binding site [nucleotide binding]; other site 476213006892 L21 binding site [polypeptide binding]; other site 476213006893 L13 binding site [polypeptide binding]; other site 476213006894 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 476213006895 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 476213006896 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 476213006897 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 476213006898 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 476213006899 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 476213006900 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 476213006901 active site 476213006902 dimer interface [polypeptide binding]; other site 476213006903 motif 1; other site 476213006904 motif 2; other site 476213006905 motif 3; other site 476213006906 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 476213006907 anticodon binding site; other site 476213006908 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528 476213006909 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 476213006910 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 476213006911 putative substrate binding site [chemical binding]; other site 476213006912 putative ATP binding site [chemical binding]; other site 476213006913 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 476213006914 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3001 476213006915 Phosphotransferase enzyme family; Region: APH; pfam01636 476213006916 YniB-like protein; Region: YniB; pfam14002 476213006917 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 476213006918 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 476213006919 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 476213006920 motif II; other site 476213006921 inner membrane protein; Provisional; Region: PRK11648 476213006922 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 476213006923 cell division modulator; Provisional; Region: PRK10113 476213006924 hydroperoxidase II; Provisional; Region: katE; PRK11249 476213006925 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 476213006926 tetramer interface [polypeptide binding]; other site 476213006927 heme binding pocket [chemical binding]; other site 476213006928 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 476213006929 domain interactions; other site 476213006930 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 476213006931 putative active site [active] 476213006932 YdjC motif; other site 476213006933 Mg binding site [ion binding]; other site 476213006934 putative homodimer interface [polypeptide binding]; other site 476213006935 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 476213006936 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 476213006937 NAD binding site [chemical binding]; other site 476213006938 sugar binding site [chemical binding]; other site 476213006939 divalent metal binding site [ion binding]; other site 476213006940 tetramer (dimer of dimers) interface [polypeptide binding]; other site 476213006941 dimer interface [polypeptide binding]; other site 476213006942 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 476213006943 Cupin domain; Region: Cupin_2; cl17218 476213006944 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213006945 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 476213006946 methionine cluster; other site 476213006947 active site 476213006948 phosphorylation site [posttranslational modification] 476213006949 metal binding site [ion binding]; metal-binding site 476213006950 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 476213006951 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 476213006952 active site 476213006953 P-loop; other site 476213006954 phosphorylation site [posttranslational modification] 476213006955 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 476213006956 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 476213006957 homodimer interface [polypeptide binding]; other site 476213006958 NAD binding pocket [chemical binding]; other site 476213006959 ATP binding pocket [chemical binding]; other site 476213006960 Mg binding site [ion binding]; other site 476213006961 active-site loop [active] 476213006962 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 476213006963 dimer interface [polypeptide binding]; other site 476213006964 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 476213006965 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 476213006966 putative active site [active] 476213006967 Zn binding site [ion binding]; other site 476213006968 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 476213006969 NAD(P) binding site [chemical binding]; other site 476213006970 catalytic residues [active] 476213006971 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 476213006972 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 476213006973 inhibitor-cofactor binding pocket; inhibition site 476213006974 pyridoxal 5'-phosphate binding site [chemical binding]; other site 476213006975 catalytic residue [active] 476213006976 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 476213006977 putative catalytic site [active] 476213006978 putative phosphate binding site [ion binding]; other site 476213006979 active site 476213006980 metal binding site A [ion binding]; metal-binding site 476213006981 DNA binding site [nucleotide binding] 476213006982 putative AP binding site [nucleotide binding]; other site 476213006983 putative metal binding site B [ion binding]; other site 476213006984 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 476213006985 active site 476213006986 8-oxo-dGMP binding site [chemical binding]; other site 476213006987 nudix motif; other site 476213006988 metal binding site [ion binding]; metal-binding site 476213006989 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 476213006990 glutamate dehydrogenase; Provisional; Region: PRK09414 476213006991 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 476213006992 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 476213006993 NAD(P) binding site [chemical binding]; other site 476213006994 DNA topoisomerase III; Provisional; Region: PRK07726 476213006995 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 476213006996 active site 476213006997 putative interdomain interaction site [polypeptide binding]; other site 476213006998 putative metal-binding site [ion binding]; other site 476213006999 putative nucleotide binding site [chemical binding]; other site 476213007000 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 476213007001 domain I; other site 476213007002 DNA binding groove [nucleotide binding] 476213007003 phosphate binding site [ion binding]; other site 476213007004 domain II; other site 476213007005 domain III; other site 476213007006 nucleotide binding site [chemical binding]; other site 476213007007 catalytic site [active] 476213007008 domain IV; other site 476213007009 selenophosphate synthetase; Provisional; Region: PRK00943 476213007010 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 476213007011 dimerization interface [polypeptide binding]; other site 476213007012 putative ATP binding site [chemical binding]; other site 476213007013 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 476213007014 putative FMN binding site [chemical binding]; other site 476213007015 protease 4; Provisional; Region: PRK10949 476213007016 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 476213007017 tandem repeat interface [polypeptide binding]; other site 476213007018 oligomer interface [polypeptide binding]; other site 476213007019 active site residues [active] 476213007020 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 476213007021 tandem repeat interface [polypeptide binding]; other site 476213007022 oligomer interface [polypeptide binding]; other site 476213007023 active site residues [active] 476213007024 cytoplasmic asparaginase I; Provisional; Region: ansA; PRK09461 476213007025 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 476213007026 active site 476213007027 homodimer interface [polypeptide binding]; other site 476213007028 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 476213007029 catalytic triad [active] 476213007030 metal binding site [ion binding]; metal-binding site 476213007031 conserved cis-peptide bond; other site 476213007032 benzoate transport; Region: 2A0115; TIGR00895 476213007033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213007034 putative substrate translocation pore; other site 476213007035 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 476213007036 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 476213007037 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 476213007038 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 476213007039 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 476213007040 active site 476213007041 catalytic tetrad [active] 476213007042 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 476213007043 substrate binding site [chemical binding]; other site 476213007044 ATP binding site [chemical binding]; other site 476213007045 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 476213007046 intersubunit interface [polypeptide binding]; other site 476213007047 active site 476213007048 zinc binding site [ion binding]; other site 476213007049 Na+ binding site [ion binding]; other site 476213007050 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 476213007051 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 476213007052 inhibitor binding site; inhibition site 476213007053 catalytic Zn binding site [ion binding]; other site 476213007054 structural Zn binding site [ion binding]; other site 476213007055 NADP binding site [chemical binding]; other site 476213007056 tetramer interface [polypeptide binding]; other site 476213007057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213007058 Major Facilitator Superfamily; Region: MFS_1; pfam07690 476213007059 putative substrate translocation pore; other site 476213007060 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 476213007061 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 476213007062 putative NAD(P) binding site [chemical binding]; other site 476213007063 catalytic Zn binding site [ion binding]; other site 476213007064 structural Zn binding site [ion binding]; other site 476213007065 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 476213007066 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 476213007067 methionine sulfoxide reductase B; Provisional; Region: PRK00222 476213007068 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 476213007069 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 476213007070 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 476213007071 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 476213007072 active site 476213007073 phosphate binding residues; other site 476213007074 catalytic residues [active] 476213007075 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 476213007076 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 476213007077 active site 476213007078 catalytic tetrad [active] 476213007079 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 476213007080 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 476213007081 FeS/SAM binding site; other site 476213007082 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 476213007083 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 476213007084 PrkA family serine protein kinase; Provisional; Region: PRK15455 476213007085 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 476213007086 Walker A motif; other site 476213007087 ATP binding site [chemical binding]; other site 476213007088 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 476213007089 hypothetical protein; Provisional; Region: PRK05325 476213007090 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 476213007091 putative deacylase active site [active] 476213007092 Predicted membrane protein [Function unknown]; Region: COG2707 476213007093 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 476213007094 Uncharacterized conserved protein [Function unknown]; Region: COG3189 476213007095 Domain of unknown function (DUF333); Region: DUF333; pfam03891 476213007096 hypothetical protein; Provisional; Region: PRK14760 476213007097 hypothetical protein; Provisional; Region: PRK10457 476213007098 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 476213007099 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 476213007100 leucine export protein LeuE; Provisional; Region: PRK10958 476213007101 chorismate mutase; Provisional; Region: PRK08055 476213007102 Pleckstrin homology-like domain; Region: PH-like; cl17171 476213007103 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 476213007104 transcriptional regulator MirA; Provisional; Region: PRK15043 476213007105 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 476213007106 DNA binding residues [nucleotide binding] 476213007107 dimer interface [polypeptide binding]; other site 476213007108 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 476213007109 DNA binding residues [nucleotide binding] 476213007110 aminoglycoside resistance protein; Provisional; Region: PRK13746 476213007111 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 476213007112 active site 476213007113 NTP binding site [chemical binding]; other site 476213007114 metal binding triad [ion binding]; metal-binding site 476213007115 antibiotic binding site [chemical binding]; other site 476213007116 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 476213007117 zinc/cadmium-binding protein; Provisional; Region: PRK10306 476213007118 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 476213007119 dimerization interface [polypeptide binding]; other site 476213007120 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 476213007121 Mechanosensitive ion channel; Region: MS_channel; pfam00924 476213007122 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 476213007123 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 476213007124 Walker A/P-loop; other site 476213007125 ATP binding site [chemical binding]; other site 476213007126 Q-loop/lid; other site 476213007127 ABC transporter signature motif; other site 476213007128 Walker B; other site 476213007129 D-loop; other site 476213007130 H-loop/switch region; other site 476213007131 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 476213007132 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 476213007133 Walker A/P-loop; other site 476213007134 ATP binding site [chemical binding]; other site 476213007135 Q-loop/lid; other site 476213007136 ABC transporter signature motif; other site 476213007137 Walker B; other site 476213007138 D-loop; other site 476213007139 H-loop/switch region; other site 476213007140 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 476213007141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213007142 dimer interface [polypeptide binding]; other site 476213007143 conserved gate region; other site 476213007144 putative PBP binding loops; other site 476213007145 ABC-ATPase subunit interface; other site 476213007146 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 476213007147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213007148 dimer interface [polypeptide binding]; other site 476213007149 conserved gate region; other site 476213007150 putative PBP binding loops; other site 476213007151 ABC-ATPase subunit interface; other site 476213007152 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 476213007153 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 476213007154 TRL-like protein family; Region: TRL; pfam13146 476213007155 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 476213007156 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 476213007157 BNR repeat-like domain; Region: BNR_2; pfam13088 476213007158 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 476213007159 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 476213007160 putative dimer interface [polypeptide binding]; other site 476213007161 lysozyme inhibitor; Provisional; Region: PRK13791 476213007162 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 476213007163 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 476213007164 DNA-binding site [nucleotide binding]; DNA binding site 476213007165 RNA-binding motif; other site 476213007166 Ricin-type beta-trefoil; Region: RICIN; smart00458 476213007167 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 476213007168 putative sugar binding sites [chemical binding]; other site 476213007169 Q-X-W motif; other site 476213007170 DinI-like family; Region: DinI; pfam06183 476213007171 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 476213007172 isocitrate dehydrogenase; Reviewed; Region: PRK07006 476213007173 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 476213007174 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 476213007175 probable active site [active] 476213007176 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 476213007177 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 476213007178 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 476213007179 nudix motif; other site 476213007180 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 476213007181 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 476213007182 Ligand Binding Site [chemical binding]; other site 476213007183 putative lysogenization regulator; Reviewed; Region: PRK00218 476213007184 adenylosuccinate lyase; Provisional; Region: PRK09285 476213007185 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 476213007186 tetramer interface [polypeptide binding]; other site 476213007187 active site 476213007188 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 476213007189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 476213007190 active site 476213007191 phosphorylation site [posttranslational modification] 476213007192 intermolecular recognition site; other site 476213007193 dimerization interface [polypeptide binding]; other site 476213007194 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 476213007195 DNA binding site [nucleotide binding] 476213007196 sensor protein PhoQ; Provisional; Region: PRK10815 476213007197 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 476213007198 HAMP domain; Region: HAMP; pfam00672 476213007199 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 476213007200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 476213007201 ATP binding site [chemical binding]; other site 476213007202 Mg2+ binding site [ion binding]; other site 476213007203 G-X-G motif; other site 476213007204 Uncharacterized conserved protein [Function unknown]; Region: COG2850 476213007205 peptidase T-like protein; Region: PepT-like; TIGR01883 476213007206 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 476213007207 metal binding site [ion binding]; metal-binding site 476213007208 dimer interface [polypeptide binding]; other site 476213007209 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 476213007210 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 476213007211 Walker A/P-loop; other site 476213007212 ATP binding site [chemical binding]; other site 476213007213 Q-loop/lid; other site 476213007214 ABC transporter signature motif; other site 476213007215 Walker B; other site 476213007216 D-loop; other site 476213007217 H-loop/switch region; other site 476213007218 TOBE domain; Region: TOBE_2; pfam08402 476213007219 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 476213007220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213007221 dimer interface [polypeptide binding]; other site 476213007222 conserved gate region; other site 476213007223 putative PBP binding loops; other site 476213007224 ABC-ATPase subunit interface; other site 476213007225 secreted effector protein SifA; Reviewed; Region: sifA; PRK09498 476213007226 spermidine/putrescine ABC transporter membrane protein; Reviewed; Region: potC; PRK09500 476213007227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213007228 dimer interface [polypeptide binding]; other site 476213007229 conserved gate region; other site 476213007230 putative PBP binding loops; other site 476213007231 ABC-ATPase subunit interface; other site 476213007232 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 476213007233 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 476213007234 NAD+ binding site [chemical binding]; other site 476213007235 substrate binding site [chemical binding]; other site 476213007236 Zn binding site [ion binding]; other site 476213007237 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 476213007238 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 476213007239 nucleotide binding site [chemical binding]; other site 476213007240 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 476213007241 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 476213007242 FtsX-like permease family; Region: FtsX; pfam02687 476213007243 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 476213007244 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 476213007245 Walker A/P-loop; other site 476213007246 ATP binding site [chemical binding]; other site 476213007247 Q-loop/lid; other site 476213007248 ABC transporter signature motif; other site 476213007249 Walker B; other site 476213007250 D-loop; other site 476213007251 H-loop/switch region; other site 476213007252 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 476213007253 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 476213007254 FtsX-like permease family; Region: FtsX; pfam02687 476213007255 transcription-repair coupling factor; Provisional; Region: PRK10689 476213007256 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 476213007257 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 476213007258 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 476213007259 ATP binding site [chemical binding]; other site 476213007260 putative Mg++ binding site [ion binding]; other site 476213007261 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 476213007262 nucleotide binding region [chemical binding]; other site 476213007263 ATP-binding site [chemical binding]; other site 476213007264 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 476213007265 L,D-transpeptidase; Provisional; Region: PRK10260 476213007266 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 476213007267 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 476213007268 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 476213007269 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 476213007270 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 476213007271 hypothetical protein; Provisional; Region: PRK11280 476213007272 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 476213007273 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 476213007274 hypothetical protein; Provisional; Region: PRK04940 476213007275 beta-hexosaminidase; Provisional; Region: PRK05337 476213007276 Phosphotransferase enzyme family; Region: APH; pfam01636 476213007277 thiamine kinase; Provisional; Region: thiK; PRK10271 476213007278 substrate binding site [chemical binding]; other site 476213007279 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 476213007280 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 476213007281 putative dimer interface [polypeptide binding]; other site 476213007282 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 476213007283 nucleotide binding site/active site [active] 476213007284 HIT family signature motif; other site 476213007285 catalytic residue [active] 476213007286 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 476213007287 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 476213007288 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 476213007289 active site turn [active] 476213007290 phosphorylation site [posttranslational modification] 476213007291 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 476213007292 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 476213007293 active site 476213007294 DNA polymerase III subunit delta'; Validated; Region: PRK07993 476213007295 DNA polymerase III subunit delta'; Validated; Region: PRK08485 476213007296 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 476213007297 thymidylate kinase; Validated; Region: tmk; PRK00698 476213007298 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 476213007299 TMP-binding site; other site 476213007300 ATP-binding site [chemical binding]; other site 476213007301 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 476213007302 dimerization interface [polypeptide binding]; other site 476213007303 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 476213007304 pyridoxal 5'-phosphate binding site [chemical binding]; other site 476213007305 catalytic residue [active] 476213007306 Integrase core domain; Region: rve; pfam00665 476213007307 Integrase core domain; Region: rve_3; pfam13683 476213007308 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 476213007309 Helix-turn-helix domain; Region: HTH_28; pfam13518 476213007310 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 476213007311 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 476213007312 dimer interface [polypeptide binding]; other site 476213007313 active site 476213007314 acyl carrier protein; Provisional; Region: acpP; PRK00982 476213007315 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 476213007316 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 476213007317 NAD(P) binding site [chemical binding]; other site 476213007318 homotetramer interface [polypeptide binding]; other site 476213007319 homodimer interface [polypeptide binding]; other site 476213007320 active site 476213007321 Acyl transferase domain; Region: Acyl_transf_1; cl08282 476213007322 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 476213007323 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 476213007324 dimer interface [polypeptide binding]; other site 476213007325 active site 476213007326 CoA binding pocket [chemical binding]; other site 476213007327 putative phosphate acyltransferase; Provisional; Region: PRK05331 476213007328 hypothetical protein; Provisional; Region: PRK11193 476213007329 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 476213007330 active site 476213007331 dimer interface [polypeptide binding]; other site 476213007332 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 476213007333 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 476213007334 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 476213007335 RNA binding surface [nucleotide binding]; other site 476213007336 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 476213007337 active site 476213007338 Protein of unknown function (DUF2655); Region: DUF2655; pfam10848 476213007339 ribonuclease E; Reviewed; Region: rne; PRK10811 476213007340 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 476213007341 homodimer interface [polypeptide binding]; other site 476213007342 oligonucleotide binding site [chemical binding]; other site 476213007343 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 476213007344 Protein of unknown function (DUF3157); Region: DUF3157; pfam11355 476213007345 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 476213007346 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 476213007347 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 476213007348 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 476213007349 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 476213007350 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 476213007351 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 476213007352 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 476213007353 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 476213007354 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 476213007355 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 476213007356 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12694 476213007357 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 476213007358 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 476213007359 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 476213007360 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 476213007361 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 476213007362 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 476213007363 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 476213007364 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 476213007365 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 476213007366 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 476213007367 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 476213007368 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 476213007369 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 476213007370 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 476213007371 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 476213007372 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 476213007373 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 476213007374 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 476213007375 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 476213007376 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 476213007377 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 476213007378 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 476213007379 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 476213007380 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 476213007381 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 476213007382 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 476213007383 hypothetical protein; Provisional; Region: PRK11239 476213007384 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 476213007385 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 476213007386 multidrug resistance protein MdtH; Provisional; Region: PRK11646 476213007387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213007388 putative substrate translocation pore; other site 476213007389 glutaredoxin 2; Provisional; Region: PRK10387 476213007390 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 476213007391 C-terminal domain interface [polypeptide binding]; other site 476213007392 GSH binding site (G-site) [chemical binding]; other site 476213007393 catalytic residues [active] 476213007394 putative dimer interface [polypeptide binding]; other site 476213007395 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 476213007396 N-terminal domain interface [polypeptide binding]; other site 476213007397 lipoprotein; Provisional; Region: PRK10598 476213007398 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 476213007399 active site 476213007400 substrate binding pocket [chemical binding]; other site 476213007401 dimer interface [polypeptide binding]; other site 476213007402 DNA damage-inducible protein I; Provisional; Region: PRK10597 476213007403 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 476213007404 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 476213007405 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 476213007406 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 476213007407 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 476213007408 hypothetical protein; Provisional; Region: PRK03757 476213007409 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 476213007410 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 476213007411 active site residue [active] 476213007412 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 476213007413 putative acyl-acceptor binding pocket; other site 476213007414 drug efflux system protein MdtG; Provisional; Region: PRK09874 476213007415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213007416 putative substrate translocation pore; other site 476213007417 lipoprotein; Provisional; Region: PRK10175 476213007418 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 476213007419 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 476213007420 Ligand binding site; other site 476213007421 DXD motif; other site 476213007422 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 476213007423 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 476213007424 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 476213007425 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 476213007426 putative active site [active] 476213007427 catalytic site [active] 476213007428 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 476213007429 putative active site [active] 476213007430 catalytic site [active] 476213007431 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 476213007432 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 476213007433 major curlin subunit; Provisional; Region: csgA; PRK10051 476213007434 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 476213007435 Curlin associated repeat; Region: Curlin_rpt; pfam07012 476213007436 Curlin associated repeat; Region: Curlin_rpt; pfam07012 476213007437 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 476213007438 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 476213007439 DNA binding residues [nucleotide binding] 476213007440 dimerization interface [polypeptide binding]; other site 476213007441 curli assembly protein CsgE; Provisional; Region: PRK10386 476213007442 curli assembly protein CsgF; Provisional; Region: PRK10050 476213007443 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 476213007444 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 476213007445 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 476213007446 putative hydrolase; Validated; Region: PRK09248 476213007447 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 476213007448 active site 476213007449 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 476213007450 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 476213007451 putative ligand binding site [chemical binding]; other site 476213007452 NAD binding site [chemical binding]; other site 476213007453 dimerization interface [polypeptide binding]; other site 476213007454 catalytic site [active] 476213007455 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 476213007456 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 476213007457 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 476213007458 putative sialic acid transporter; Provisional; Region: PRK12307 476213007459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213007460 putative substrate translocation pore; other site 476213007461 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 476213007462 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 476213007463 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 476213007464 beta-alpha-beta structure motif; other site 476213007465 NAD binding pocket [chemical binding]; other site 476213007466 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 476213007467 putative active site cavity [active] 476213007468 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 476213007469 Na binding site [ion binding]; other site 476213007470 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 476213007471 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 476213007472 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 476213007473 putative active site [active] 476213007474 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 476213007475 hypothetical protein; Provisional; Region: PRK10536 476213007476 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 476213007477 Na binding site [ion binding]; other site 476213007478 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 476213007479 Predicted transcriptional regulator [Transcription]; Region: COG3905 476213007480 DNA-binding domain of Proline dehydrogenase; Region: Pro_dh-DNA_bdg; pfam14850 476213007481 Proline dehydrogenase; Region: Pro_dh; pfam01619 476213007482 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 476213007483 Glutamate binding site [chemical binding]; other site 476213007484 NAD binding site [chemical binding]; other site 476213007485 catalytic residues [active] 476213007486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 476213007487 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 476213007488 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 476213007489 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 476213007490 General stress protein [General function prediction only]; Region: GsiB; COG3729 476213007491 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 476213007492 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 476213007493 hypothetical protein; Provisional; Region: PRK10174 476213007494 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 476213007495 catalytic core [active] 476213007496 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 476213007497 catalytic residues [active] 476213007498 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 476213007499 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 476213007500 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 476213007501 catalytic residues [active] 476213007502 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 476213007503 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 476213007504 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 476213007505 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 476213007506 DsbD alpha interface [polypeptide binding]; other site 476213007507 catalytic residues [active] 476213007508 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 476213007509 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 476213007510 HSP70 interaction site [polypeptide binding]; other site 476213007511 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 476213007512 substrate binding site [polypeptide binding]; other site 476213007513 dimer interface [polypeptide binding]; other site 476213007514 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 476213007515 anti-adapter protein IraM; Provisional; Region: PRK09919 476213007516 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 476213007517 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 476213007518 Cupin domain; Region: Cupin_2; pfam07883 476213007519 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213007520 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 476213007521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213007522 putative substrate translocation pore; other site 476213007523 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Region: HpaI; TIGR02311 476213007524 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 476213007525 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 476213007526 putative substrate binding pocket [chemical binding]; other site 476213007527 trimer interface [polypeptide binding]; other site 476213007528 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 476213007529 putative active site [active] 476213007530 putative metal binding site [ion binding]; other site 476213007531 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 476213007532 NAD binding site [chemical binding]; other site 476213007533 catalytic residues [active] 476213007534 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203 476213007535 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 476213007536 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 476213007537 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 476213007538 Transcriptional regulators [Transcription]; Region: MarR; COG1846 476213007539 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 476213007540 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 476213007541 4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486 476213007542 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 476213007543 active site 476213007544 homotetramer interface [polypeptide binding]; other site 476213007545 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 476213007546 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 476213007547 active site 476213007548 phosphorylation site [posttranslational modification] 476213007549 intermolecular recognition site; other site 476213007550 dimerization interface [polypeptide binding]; other site 476213007551 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 476213007552 DNA binding site [nucleotide binding] 476213007553 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 476213007554 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 476213007555 dimerization interface [polypeptide binding]; other site 476213007556 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 476213007557 dimer interface [polypeptide binding]; other site 476213007558 phosphorylation site [posttranslational modification] 476213007559 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 476213007560 ATP binding site [chemical binding]; other site 476213007561 Mg2+ binding site [ion binding]; other site 476213007562 G-X-G motif; other site 476213007563 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 476213007564 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 476213007565 Enterobacterial virulence protein IpgD; Region: IpgD; pfam05925 476213007566 type III secretion chaperone protein SigE; Provisional; Region: PRK15202 476213007567 secreted effector protein PipB; Provisional; Region: PRK15197 476213007568 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 476213007569 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 476213007570 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 476213007571 PipA protein; Region: PipA; pfam07108 476213007572 YccA-like proteins; Region: YccA_like; cd10433 476213007573 sulfur transfer protein TusE; Provisional; Region: PRK11508 476213007574 acylphosphatase; Provisional; Region: PRK14426 476213007575 Cupin domain; Region: Cupin_2; cl17218 476213007576 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 476213007577 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213007578 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 476213007579 substrate binding site [chemical binding]; other site 476213007580 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 476213007581 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 476213007582 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 476213007583 putative RNA binding site [nucleotide binding]; other site 476213007584 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 476213007585 S-adenosylmethionine binding site [chemical binding]; other site 476213007586 heat shock protein HspQ; Provisional; Region: PRK14129 476213007587 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 476213007588 hypothetical protein; Provisional; Region: PRK03641 476213007589 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 476213007590 active site 476213007591 dimer interfaces [polypeptide binding]; other site 476213007592 catalytic residues [active] 476213007593 DNA helicase IV; Provisional; Region: helD; PRK11054 476213007594 DNA helicase IV / RNA helicase N terminal; Region: Helicase_IV_N; pfam12462 476213007595 Part of AAA domain; Region: AAA_19; pfam13245 476213007596 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 476213007597 Predicted membrane protein [Function unknown]; Region: COG3304 476213007598 Domain of unknown function (DUF307); Region: DUF307; pfam03733 476213007599 Domain of unknown function (DUF307); Region: DUF307; pfam03733 476213007600 TIGR01666 family membrane protein; Region: YCCS 476213007601 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 476213007602 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 476213007603 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 476213007604 TfoX C-terminal domain; Region: TfoX_C; pfam04994 476213007605 cell division inhibitor SulA; Region: sula; TIGR00623 476213007606 outer membrane protein A; Reviewed; Region: PRK10808 476213007607 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 476213007608 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 476213007609 ligand binding site [chemical binding]; other site 476213007610 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 476213007611 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 476213007612 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 476213007613 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 476213007614 active site 1 [active] 476213007615 dimer interface [polypeptide binding]; other site 476213007616 active site 2 [active] 476213007617 ribosome modulation factor; Provisional; Region: PRK14563 476213007618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 476213007619 paraquat-inducible protein B; Provisional; Region: PRK10807 476213007620 mce related protein; Region: MCE; pfam02470 476213007621 mce related protein; Region: MCE; pfam02470 476213007622 mce related protein; Region: MCE; pfam02470 476213007623 Biogenesis of lysosome-related organelles complex-1 subunit 2; Region: BLOC1_2; pfam10046 476213007624 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 476213007625 Paraquat-inducible protein A; Region: PqiA; pfam04403 476213007626 Paraquat-inducible protein A; Region: PqiA; pfam04403 476213007627 ABC transporter ATPase component; Reviewed; Region: PRK11147 476213007628 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 476213007629 ABC transporter; Region: ABC_tran_2; pfam12848 476213007630 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 476213007631 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 476213007632 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 476213007633 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 476213007634 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 476213007635 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 476213007636 S-adenosylmethionine binding site [chemical binding]; other site 476213007637 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 476213007638 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 476213007639 MOSC domain; Region: MOSC; pfam03473 476213007640 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 476213007641 catalytic loop [active] 476213007642 iron binding site [ion binding]; other site 476213007643 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 476213007644 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 476213007645 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 476213007646 quinone interaction residues [chemical binding]; other site 476213007647 active site 476213007648 catalytic residues [active] 476213007649 FMN binding site [chemical binding]; other site 476213007650 substrate binding site [chemical binding]; other site 476213007651 aminopeptidase N; Provisional; Region: pepN; PRK14015 476213007652 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 476213007653 active site 476213007654 Zn binding site [ion binding]; other site 476213007655 DinI-like family; Region: DinI; cl11630 476213007656 hypothetical protein; Provisional; Region: PRK09951 476213007657 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 476213007658 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 476213007659 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 476213007660 Dermonecrotoxin of the Papain-like fold; Region: Tox-PLDMTX; pfam15645 476213007661 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 476213007662 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 476213007663 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 476213007664 Protein of unknown function (DUF1002); Region: DUF1002; cl19854 476213007665 Phage Tail Collar Domain; Region: Collar; pfam07484 476213007666 Phage-related protein, tail component [Function unknown]; Region: COG4723 476213007667 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 476213007668 MPN+ (JAMM) motif; other site 476213007669 Zinc-binding site [ion binding]; other site 476213007670 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 476213007671 NlpC/P60 family; Region: NLPC_P60; cl17555 476213007672 Phage-related protein [Function unknown]; Region: gp18; COG4672 476213007673 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cl00891 476213007674 active site 476213007675 Cu2+ binding site [ion binding]; other site 476213007676 Zn2+ binding site [ion binding]; other site 476213007677 P-class dimer interface [polypeptide binding]; other site 476213007678 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 476213007679 Phage-related protein [Function unknown]; Region: COG4718 476213007680 Phage-related minor tail protein [Function unknown]; Region: COG5281 476213007681 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 476213007682 phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541 476213007683 Minor tail protein T; Region: Phage_tail_T; cl05636 476213007684 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 476213007685 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 476213007686 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 476213007687 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 476213007688 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 476213007689 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 476213007690 Uncharacterized conserved protein [Function unknown]; Region: COG5471 476213007691 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 476213007692 oligomer interface [polypeptide binding]; other site 476213007693 active site residues [active] 476213007694 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 476213007695 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 476213007696 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 476213007697 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 476213007698 Bacteriophage Rz lysis protein; Region: Phage_lysis; pfam03245 476213007699 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 476213007700 catalytic residues [active] 476213007701 phage holin, lambda family; Region: holin_lambda; TIGR01594 476213007702 PipA protein; Region: PipA; pfam07108 476213007703 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 476213007704 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 476213007705 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 476213007706 DinI-like family; Region: DinI; pfam06183 476213007707 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 476213007708 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 476213007709 putative replication protein; Provisional; Region: PRK12377 476213007710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 476213007711 Walker A motif; other site 476213007712 ATP binding site [chemical binding]; other site 476213007713 Walker B motif; other site 476213007714 arginine finger; other site 476213007715 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 476213007716 primosomal protein DnaI; Provisional; Region: PRK02854 476213007717 Bacteriophage CII protein; Region: Phage_CII; pfam05269 476213007718 transcriptional repressor DicA; Reviewed; Region: PRK09706 476213007719 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 476213007720 non-specific DNA binding site [nucleotide binding]; other site 476213007721 salt bridge; other site 476213007722 sequence-specific DNA binding site [nucleotide binding]; other site 476213007723 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 476213007724 exonuclease VIII; Reviewed; Region: PRK09709 476213007725 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 476213007726 RecT family; Region: RecT; pfam03837 476213007727 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 476213007728 integrase; Provisional; Region: PRK09692 476213007729 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 476213007730 active site 476213007731 Int/Topo IB signature motif; other site 476213007732 SoxR reducing system protein RseC; Provisional; Region: PRK10862 476213007733 anti-sigma E factor; Provisional; Region: rseB; PRK09455 476213007734 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 476213007735 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 476213007736 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 476213007737 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 476213007738 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 476213007739 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 476213007740 DNA binding residues [nucleotide binding] 476213007741 L-aspartate oxidase; Provisional; Region: PRK09077 476213007742 L-aspartate oxidase; Provisional; Region: PRK06175 476213007743 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 476213007744 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 476213007745 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 476213007746 S-adenosylmethionine binding site [chemical binding]; other site 476213007747 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 476213007748 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 476213007749 ATP binding site [chemical binding]; other site 476213007750 Mg++ binding site [ion binding]; other site 476213007751 motif III; other site 476213007752 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 476213007753 nucleotide binding region [chemical binding]; other site 476213007754 ATP-binding site [chemical binding]; other site 476213007755 Transcriptional regulator [Transcription]; Region: LysR; COG0583 476213007756 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213007757 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 476213007758 dimerization interface [polypeptide binding]; other site 476213007759 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 476213007760 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 476213007761 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 476213007762 ligand binding site [chemical binding]; other site 476213007763 active site 476213007764 UGI interface [polypeptide binding]; other site 476213007765 catalytic site [active] 476213007766 putative methyltransferase; Provisional; Region: PRK10864 476213007767 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 476213007768 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 476213007769 thioredoxin 2; Provisional; Region: PRK10996 476213007770 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 476213007771 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 476213007772 catalytic residues [active] 476213007773 Uncharacterized conserved protein [Function unknown]; Region: COG3148 476213007774 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 476213007775 CoA binding domain; Region: CoA_binding_2; pfam13380 476213007776 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 476213007777 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 476213007778 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 476213007779 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 476213007780 Coenzyme A binding pocket [chemical binding]; other site 476213007781 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 476213007782 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 476213007783 domain interface [polypeptide binding]; other site 476213007784 putative active site [active] 476213007785 catalytic site [active] 476213007786 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 476213007787 domain interface [polypeptide binding]; other site 476213007788 putative active site [active] 476213007789 catalytic site [active] 476213007790 lipoprotein; Provisional; Region: PRK10759 476213007791 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 476213007792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213007793 putative substrate translocation pore; other site 476213007794 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 476213007795 protein disaggregation chaperone; Provisional; Region: PRK10865 476213007796 Clp amino terminal domain; Region: Clp_N; pfam02861 476213007797 Clp amino terminal domain; Region: Clp_N; pfam02861 476213007798 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 476213007799 Walker A motif; other site 476213007800 ATP binding site [chemical binding]; other site 476213007801 Walker B motif; other site 476213007802 arginine finger; other site 476213007803 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 476213007804 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 476213007805 Walker A motif; other site 476213007806 ATP binding site [chemical binding]; other site 476213007807 Walker B motif; other site 476213007808 arginine finger; other site 476213007809 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 476213007810 hypothetical protein; Provisional; Region: PRK10723 476213007811 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 476213007812 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 476213007813 RNA binding surface [nucleotide binding]; other site 476213007814 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 476213007815 active site 476213007816 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 476213007817 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 476213007818 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 476213007819 30S subunit binding site; other site 476213007820 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 476213007821 Chorismate mutase type II; Region: CM_2; cl00693 476213007822 Prephenate dehydratase; Region: PDT; pfam00800 476213007823 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 476213007824 putative L-Phe binding site [chemical binding]; other site 476213007825 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 476213007826 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 476213007827 Chorismate mutase type II; Region: CM_2; cl00693 476213007828 prephenate dehydrogenase; Validated; Region: PRK08507 476213007829 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 476213007830 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 476213007831 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 476213007832 metal binding site [ion binding]; metal-binding site 476213007833 active site 476213007834 I-site; other site 476213007835 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 476213007836 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 476213007837 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 476213007838 RimM N-terminal domain; Region: RimM; pfam01782 476213007839 PRC-barrel domain; Region: PRC; pfam05239 476213007840 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 476213007841 signal recognition particle protein; Provisional; Region: PRK10867 476213007842 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 476213007843 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 476213007844 P loop; other site 476213007845 GTP binding site [chemical binding]; other site 476213007846 Signal peptide binding domain; Region: SRP_SPB; pfam02978 476213007847 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 476213007848 hypothetical protein; Provisional; Region: PRK11573 476213007849 Domain of unknown function DUF21; Region: DUF21; pfam01595 476213007850 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 476213007851 Transporter associated domain; Region: CorC_HlyC; smart01091 476213007852 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; cl19511 476213007853 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 476213007854 dimer interface [polypeptide binding]; other site 476213007855 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 476213007856 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 476213007857 recombination and repair protein; Provisional; Region: PRK10869 476213007858 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 476213007859 Walker A/P-loop; other site 476213007860 ATP binding site [chemical binding]; other site 476213007861 Q-loop/lid; other site 476213007862 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 476213007863 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 476213007864 ABC transporter signature motif; other site 476213007865 Walker B; other site 476213007866 D-loop; other site 476213007867 H-loop/switch region; other site 476213007868 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 476213007869 hypothetical protein; Validated; Region: PRK01777 476213007870 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 476213007871 putative coenzyme Q binding site [chemical binding]; other site 476213007872 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 476213007873 SmpB-tmRNA interface; other site 476213007874 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 476213007875 Outer membrane efflux protein; Region: OEP; pfam02321 476213007876 Outer membrane efflux protein; Region: OEP; pfam02321 476213007877 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 476213007878 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 476213007879 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 476213007880 Walker A/P-loop; other site 476213007881 ATP binding site [chemical binding]; other site 476213007882 Q-loop/lid; other site 476213007883 ABC transporter signature motif; other site 476213007884 Walker B; other site 476213007885 D-loop; other site 476213007886 H-loop/switch region; other site 476213007887 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 476213007888 HlyD family secretion protein; Region: HlyD_3; pfam13437 476213007889 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 476213007890 putative transposase OrfB; Reviewed; Region: PHA02517 476213007891 HTH-like domain; Region: HTH_21; pfam13276 476213007892 Integrase core domain; Region: rve; pfam00665 476213007893 Integrase core domain; Region: rve_3; pfam13683 476213007894 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 476213007895 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 476213007896 putative active site [active] 476213007897 putative NTP binding site [chemical binding]; other site 476213007898 putative nucleic acid binding site [nucleotide binding]; other site 476213007899 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; pfam10137 476213007900 flagellin; Validated; Region: PRK08026 476213007901 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 476213007902 Flagellin D3 domain; Region: Flagellin_D3; pfam08884 476213007903 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 476213007904 multiple promoter invertase; Provisional; Region: mpi; PRK13413 476213007905 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 476213007906 catalytic residues [active] 476213007907 catalytic nucleophile [active] 476213007908 Presynaptic Site I dimer interface [polypeptide binding]; other site 476213007909 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 476213007910 Synaptic Flat tetramer interface [polypeptide binding]; other site 476213007911 Synaptic Site I dimer interface [polypeptide binding]; other site 476213007912 DNA binding site [nucleotide binding] 476213007913 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569 476213007914 DNA-binding interface [nucleotide binding]; DNA binding site 476213007915 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 476213007916 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 476213007917 homodimer interface [polypeptide binding]; other site 476213007918 active site 476213007919 TDP-binding site; other site 476213007920 acceptor substrate-binding pocket; other site 476213007921 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 476213007922 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 476213007923 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 476213007924 Walker A/P-loop; other site 476213007925 ATP binding site [chemical binding]; other site 476213007926 Q-loop/lid; other site 476213007927 ABC transporter signature motif; other site 476213007928 Walker B; other site 476213007929 D-loop; other site 476213007930 H-loop/switch region; other site 476213007931 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 476213007932 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 476213007933 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 476213007934 Walker A/P-loop; other site 476213007935 ATP binding site [chemical binding]; other site 476213007936 Q-loop/lid; other site 476213007937 ABC transporter signature motif; other site 476213007938 Walker B; other site 476213007939 D-loop; other site 476213007940 H-loop/switch region; other site 476213007941 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 476213007942 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 476213007943 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 476213007944 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 476213007945 outer membrane receptor FepA; Provisional; Region: PRK13528 476213007946 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 476213007947 N-terminal plug; other site 476213007948 ligand-binding site [chemical binding]; other site 476213007949 secreted effector protein PipB2; Provisional; Region: PRK15196 476213007950 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 476213007951 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 476213007952 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 476213007953 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 476213007954 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 476213007955 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 476213007956 antimicrobial resistance protein Mig-14; Provisional; Region: PRK15312 476213007957 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 476213007958 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 476213007959 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 476213007960 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 476213007961 dimer interface [polypeptide binding]; other site 476213007962 phosphorylation site [posttranslational modification] 476213007963 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 476213007964 ATP binding site [chemical binding]; other site 476213007965 Mg2+ binding site [ion binding]; other site 476213007966 G-X-G motif; other site 476213007967 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 476213007968 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 476213007969 active site 476213007970 phosphorylation site [posttranslational modification] 476213007971 intermolecular recognition site; other site 476213007972 dimerization interface [polypeptide binding]; other site 476213007973 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 476213007974 DNA binding site [nucleotide binding] 476213007975 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 476213007976 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 476213007977 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 476213007978 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 476213007979 substrate binding pocket [chemical binding]; other site 476213007980 active site 476213007981 iron coordination sites [ion binding]; other site 476213007982 hydroxyglutarate oxidase; Provisional; Region: PRK11728 476213007983 Predicted dehydrogenase [General function prediction only]; Region: COG0579 476213007984 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 476213007985 tetramerization interface [polypeptide binding]; other site 476213007986 NAD(P) binding site [chemical binding]; other site 476213007987 catalytic residues [active] 476213007988 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 476213007989 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 476213007990 inhibitor-cofactor binding pocket; inhibition site 476213007991 pyridoxal 5'-phosphate binding site [chemical binding]; other site 476213007992 catalytic residue [active] 476213007993 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 476213007994 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 476213007995 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 476213007996 helix_turn_helix gluconate operon transcriptional repressor; Region: HTH_GNTR; smart00345 476213007997 DNA-binding site [nucleotide binding]; DNA binding site 476213007998 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 476213007999 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 476213008000 bacterial OsmY and nodulation domain; Region: BON; smart00749 476213008001 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 476213008002 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 476213008003 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 476213008004 dimerization interface [polypeptide binding]; other site 476213008005 putative DNA binding site [nucleotide binding]; other site 476213008006 putative Zn2+ binding site [ion binding]; other site 476213008007 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 476213008008 active site residue [active] 476213008009 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 476213008010 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 476213008011 Domain in histone-like proteins of HNS family; Region: HNS; cl19571 476213008012 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 476213008013 hypothetical protein; Provisional; Region: PRK10556 476213008014 hypothetical protein; Provisional; Region: PRK10132 476213008015 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 476213008016 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 476213008017 DNA-binding site [nucleotide binding]; DNA binding site 476213008018 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 476213008019 pyridoxal 5'-phosphate binding site [chemical binding]; other site 476213008020 homodimer interface [polypeptide binding]; other site 476213008021 catalytic residue [active] 476213008022 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 476213008023 Uncharacterized conserved protein [Function unknown]; Region: COG2128 476213008024 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 476213008025 catalytic residues [active] 476213008026 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 476213008027 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 476213008028 dimer interface [polypeptide binding]; other site 476213008029 putative radical transfer pathway; other site 476213008030 diiron center [ion binding]; other site 476213008031 tyrosyl radical; other site 476213008032 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 476213008033 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 476213008034 Walker A/P-loop; other site 476213008035 ATP binding site [chemical binding]; other site 476213008036 Q-loop/lid; other site 476213008037 ABC transporter signature motif; other site 476213008038 Walker B; other site 476213008039 D-loop; other site 476213008040 H-loop/switch region; other site 476213008041 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 476213008042 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 476213008043 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213008044 dimer interface [polypeptide binding]; other site 476213008045 conserved gate region; other site 476213008046 putative PBP binding loops; other site 476213008047 ABC-ATPase subunit interface; other site 476213008048 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 476213008049 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 476213008050 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213008051 putative substrate translocation pore; other site 476213008052 transcriptional repressor MprA; Provisional; Region: PRK10870 476213008053 Transcriptional regulators [Transcription]; Region: MarR; COG1846 476213008054 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 476213008055 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 476213008056 HlyD family secretion protein; Region: HlyD_3; pfam13437 476213008057 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 476213008058 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213008059 putative substrate translocation pore; other site 476213008060 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 476213008061 S-ribosylhomocysteinase; Provisional; Region: PRK02260 476213008062 glutamate--cysteine ligase; Provisional; Region: PRK02107 476213008063 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 476213008064 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 476213008065 active site 476213008066 motif I; other site 476213008067 motif II; other site 476213008068 carbon storage regulator; Provisional; Region: PRK01712 476213008069 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 476213008070 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 476213008071 motif 1; other site 476213008072 active site 476213008073 motif 2; other site 476213008074 motif 3; other site 476213008075 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 476213008076 DHHA1 domain; Region: DHHA1; pfam02272 476213008077 recombination regulator RecX; Reviewed; Region: recX; PRK00117 476213008078 recombinase A; Provisional; Region: recA; PRK09354 476213008079 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 476213008080 hexamer interface [polypeptide binding]; other site 476213008081 Walker A motif; other site 476213008082 ATP binding site [chemical binding]; other site 476213008083 Walker B motif; other site 476213008084 hypothetical protein; Validated; Region: PRK03661 476213008085 murein hydrolase B; Provisional; Region: PRK10760 476213008086 lytic murein transglycosylase B; Region: MltB; TIGR02282 476213008087 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 476213008088 N-acetyl-D-glucosamine binding site [chemical binding]; other site 476213008089 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 476213008090 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 476213008091 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 476213008092 Nucleoside recognition; Region: Gate; pfam07670 476213008093 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 476213008094 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 476213008095 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 476213008096 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 476213008097 putative NAD(P) binding site [chemical binding]; other site 476213008098 active site 476213008099 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 476213008100 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 476213008101 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 476213008102 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 476213008103 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 476213008104 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 476213008105 putative active site [active] 476213008106 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 476213008107 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 476213008108 GAF domain; Region: GAF; pfam01590 476213008109 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 476213008110 Walker A motif; other site 476213008111 ATP binding site [chemical binding]; other site 476213008112 Walker B motif; other site 476213008113 arginine finger; other site 476213008114 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 476213008115 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 476213008116 Acylphosphatase; Region: Acylphosphatase; pfam00708 476213008117 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 476213008118 HypF finger; Region: zf-HYPF; pfam07503 476213008119 HypF finger; Region: zf-HYPF; pfam07503 476213008120 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 476213008121 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 476213008122 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 476213008123 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 476213008124 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 476213008125 nickel binding site [ion binding]; other site 476213008126 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 476213008127 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 476213008128 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 476213008129 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 476213008130 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 476213008131 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 476213008132 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 476213008133 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 476213008134 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 476213008135 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 476213008136 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 476213008137 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 476213008138 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 476213008139 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 476213008140 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 476213008141 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 476213008142 hydrogenase assembly chaperone; Provisional; Region: PRK10409 476213008143 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 476213008144 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 476213008145 dimerization interface [polypeptide binding]; other site 476213008146 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 476213008147 ATP binding site [chemical binding]; other site 476213008148 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 476213008149 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 476213008150 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 476213008151 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 476213008152 Walker A motif; other site 476213008153 ATP binding site [chemical binding]; other site 476213008154 Walker B motif; other site 476213008155 arginine finger; other site 476213008156 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 476213008157 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 476213008158 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 476213008159 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 476213008160 metal binding site [ion binding]; metal-binding site 476213008161 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 476213008162 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 476213008163 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 476213008164 ABC-ATPase subunit interface; other site 476213008165 dimer interface [polypeptide binding]; other site 476213008166 putative PBP binding regions; other site 476213008167 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 476213008168 ABC-ATPase subunit interface; other site 476213008169 dimer interface [polypeptide binding]; other site 476213008170 putative PBP binding regions; other site 476213008171 transcriptional activator SprB; Provisional; Region: PRK15320 476213008172 transcriptional regulator SirC; Provisional; Region: PRK15044 476213008173 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213008174 putative type III secretion system effector protein OrgC; Provisional; Region: PRK15321 476213008175 invasion protein OrgB; Provisional; Region: PRK15322 476213008176 invasion protein OrgA; Provisional; Region: PRK15323 476213008177 type III secretion system lipoprotein PrgK; Provisional; Region: PRK15324 476213008178 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 476213008179 type III secretion system needle complex protein PrgI; Provisional; Region: PRK15326 476213008180 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327 476213008181 transcriptional regulator HilD; Provisional; Region: PRK15185 476213008182 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213008183 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213008184 invasion protein regulator; Provisional; Region: PRK12370 476213008185 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 476213008186 DNA binding site [nucleotide binding] 476213008187 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 476213008188 binding surface 476213008189 TPR motif; other site 476213008190 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 476213008191 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 476213008192 N-acetyl-D-glucosamine binding site [chemical binding]; other site 476213008193 catalytic residue [active] 476213008194 pathogenicity island 1 effector protein StpP; Provisional; Region: PRK15375 476213008195 SicP binding; Region: SicP-binding; pfam09119 476213008196 GTPase-activating protein (GAP) domain found in bacterial cytotoxins, ExoS, SptP, and YopE. Part of protein secretion system; stimulates Rac1- dependent cytoskeletal changes that promote bacterial internalization; Region: ToxGAP; cd00219 476213008197 switch II binding region; other site 476213008198 Rac1 P-loop interaction site [polypeptide binding]; other site 476213008199 GTP binding residues [chemical binding]; other site 476213008200 switch I binding region; other site 476213008201 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047 476213008202 active site 476213008203 chaperone protein SicP; Provisional; Region: PRK15329 476213008204 putative acyl carrier protein IacP; Validated; Region: PRK08172 476213008205 pathogenicity island 1 effector protein SipA; Provisional; Region: PRK15376 476213008206 cell invasion protein SipD; Provisional; Region: PRK15330 476213008207 pathogenicity island 1 effector protein SipC; Provisional; Region: PRK15373 476213008208 pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374 476213008209 Secretion system effector C (SseC) like family; Region: SseC; pfam04888 476213008210 chaperone protein SicA; Provisional; Region: PRK15331 476213008211 Tetratricopeptide repeat; Region: TPR_3; pfam07720 476213008212 Tetratricopeptide repeat; Region: TPR_3; pfam07720 476213008213 type III secretion system protein SpaS; Validated; Region: PRK08156 476213008214 type III secretion system protein SpaR; Provisional; Region: PRK15332 476213008215 type III secretion system protein SpaQ; Provisional; Region: PRK15333 476213008216 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 476213008217 type III secretion system protein SpaO; Validated; Region: PRK08158 476213008218 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 476213008219 Surface presentation of antigens protein; Region: SPAN; cl19597 476213008220 Salmonella surface presentation of antigen gene type M protein; Region: SPAM; pfam02090 476213008221 ATP synthase SpaL; Validated; Region: PRK08149 476213008222 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 476213008223 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 476213008224 Walker A motif; other site 476213008225 ATP binding site [chemical binding]; other site 476213008226 Walker B motif; other site 476213008227 type III secretion system chaperone SpaK; Provisional; Region: PRK15336 476213008228 type III secretion system protein InvA; Provisional; Region: PRK15337 476213008229 type III secretion system regulator InvE; Provisional; Region: PRK15338 476213008230 type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568 476213008231 type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339 476213008232 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 476213008233 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 476213008234 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 476213008235 transcriptional regulator InvF; Provisional; Region: PRK15340 476213008236 InvH outer membrane lipoprotein; Region: InvH; pfam04741 476213008237 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 476213008238 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 476213008239 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 476213008240 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 476213008241 active site 476213008242 metal binding site [ion binding]; metal-binding site 476213008243 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 476213008244 MutS domain I; Region: MutS_I; pfam01624 476213008245 MutS domain II; Region: MutS_II; pfam05188 476213008246 MutS domain III; Region: MutS_III; pfam05192 476213008247 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 476213008248 Walker A/P-loop; other site 476213008249 ATP binding site [chemical binding]; other site 476213008250 Q-loop/lid; other site 476213008251 ABC transporter signature motif; other site 476213008252 Walker B; other site 476213008253 D-loop; other site 476213008254 H-loop/switch region; other site 476213008255 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 476213008256 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213008257 Major Facilitator Superfamily; Region: MFS_1; pfam07690 476213008258 putative substrate translocation pore; other site 476213008259 Transcriptional regulator [Transcription]; Region: LysR; COG0583 476213008260 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213008261 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 476213008262 putative effector binding pocket; other site 476213008263 dimerization interface [polypeptide binding]; other site 476213008264 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 476213008265 GntP family permease; Region: GntP_permease; pfam02447 476213008266 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 476213008267 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 476213008268 putative NAD(P) binding site [chemical binding]; other site 476213008269 active site 476213008270 putative substrate binding site [chemical binding]; other site 476213008271 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 476213008272 hypothetical protein; Provisional; Region: PRK09989 476213008273 putative aldolase; Validated; Region: PRK08130 476213008274 intersubunit interface [polypeptide binding]; other site 476213008275 active site 476213008276 Zn2+ binding site [ion binding]; other site 476213008277 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 476213008278 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 476213008279 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 476213008280 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 476213008281 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 476213008282 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 476213008283 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 476213008284 Transcriptional regulators [Transcription]; Region: MarR; COG1846 476213008285 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 476213008286 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 476213008287 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 476213008288 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 476213008289 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 476213008290 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 476213008291 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 476213008292 DNA binding residues [nucleotide binding] 476213008293 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 476213008294 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 476213008295 Peptidase family M23; Region: Peptidase_M23; pfam01551 476213008296 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 476213008297 S-adenosylmethionine binding site [chemical binding]; other site 476213008298 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 476213008299 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 476213008300 Permutation of conserved domain; other site 476213008301 active site 476213008302 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 476213008303 homotrimer interaction site [polypeptide binding]; other site 476213008304 zinc binding site [ion binding]; other site 476213008305 CDP-binding sites; other site 476213008306 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 476213008307 substrate binding site; other site 476213008308 dimer interface; other site 476213008309 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 476213008310 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 476213008311 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 476213008312 ligand-binding site [chemical binding]; other site 476213008313 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 476213008314 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 476213008315 CysD dimerization site [polypeptide binding]; other site 476213008316 G1 box; other site 476213008317 putative GEF interaction site [polypeptide binding]; other site 476213008318 GTP/Mg2+ binding site [chemical binding]; other site 476213008319 Switch I region; other site 476213008320 G2 box; other site 476213008321 G3 box; other site 476213008322 Switch II region; other site 476213008323 G4 box; other site 476213008324 G5 box; other site 476213008325 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 476213008326 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 476213008327 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 476213008328 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 476213008329 Active Sites [active] 476213008330 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 476213008331 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 476213008332 metal binding site [ion binding]; metal-binding site 476213008333 putative ssRNA endonuclease; Provisional; Region: PRK11558 476213008334 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 476213008335 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 476213008336 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 476213008337 CT1975-like protein; Region: Cas_CT1975; pfam09344 476213008338 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 476213008339 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 476213008340 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 476213008341 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 476213008342 CRISPR/Cas system-associated protein Cas3; Region: Cas3_I; cd09639 476213008343 pathogenicity island 1 effector protein SopD; Provisional; Region: PRK15379 476213008344 sulfite reductase subunit beta; Provisional; Region: PRK13504 476213008345 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 476213008346 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 476213008347 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 476213008348 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 476213008349 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 476213008350 Flavodoxin; Region: Flavodoxin_1; pfam00258 476213008351 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 476213008352 FAD binding pocket [chemical binding]; other site 476213008353 FAD binding motif [chemical binding]; other site 476213008354 catalytic residues [active] 476213008355 NAD binding pocket [chemical binding]; other site 476213008356 phosphate binding motif [ion binding]; other site 476213008357 beta-alpha-beta structure motif; other site 476213008358 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 476213008359 active site 476213008360 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 476213008361 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 476213008362 Helix-turn-helix domain; Region: HTH_28; pfam13518 476213008363 Integrase core domain; Region: rve; pfam00665 476213008364 Integrase core domain; Region: rve_3; pfam13683 476213008365 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 476213008366 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 476213008367 enolase; Provisional; Region: eno; PRK00077 476213008368 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 476213008369 dimer interface [polypeptide binding]; other site 476213008370 metal binding site [ion binding]; metal-binding site 476213008371 substrate binding pocket [chemical binding]; other site 476213008372 CTP synthetase; Validated; Region: pyrG; PRK05380 476213008373 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 476213008374 Catalytic site [active] 476213008375 active site 476213008376 UTP binding site [chemical binding]; other site 476213008377 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 476213008378 active site 476213008379 putative oxyanion hole; other site 476213008380 catalytic triad [active] 476213008381 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 476213008382 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 476213008383 homodimer interface [polypeptide binding]; other site 476213008384 metal binding site [ion binding]; metal-binding site 476213008385 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 476213008386 homodimer interface [polypeptide binding]; other site 476213008387 active site 476213008388 putative chemical substrate binding site [chemical binding]; other site 476213008389 metal binding site [ion binding]; metal-binding site 476213008390 fimbrial protein SteA; Provisional; Region: PRK15261 476213008391 putative fimbrial outer membrane usher protein SteB; Provisional; Region: PRK15273 476213008392 PapC N-terminal domain; Region: PapC_N; pfam13954 476213008393 Outer membrane usher protein; Region: Usher; pfam00577 476213008394 PapC C-terminal domain; Region: PapC_C; pfam13953 476213008395 putative periplasmic fimbrial chaperone protein SteC; Provisional; Region: PRK15274 476213008396 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 476213008397 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 476213008398 putative fimbrial protein SteD; Provisional; Region: PRK15275 476213008399 putative fimbrial subunit SteE; Provisional; Region: PRK15276 476213008400 fimbrial protein SteF; Provisional; Region: PRK15260 476213008401 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 476213008402 HD domain; Region: HD_4; pfam13328 476213008403 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 476213008404 synthetase active site [active] 476213008405 NTP binding site [chemical binding]; other site 476213008406 metal binding site [ion binding]; metal-binding site 476213008407 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 476213008408 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 476213008409 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 476213008410 TRAM domain; Region: TRAM; pfam01938 476213008411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 476213008412 S-adenosylmethionine binding site [chemical binding]; other site 476213008413 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 476213008414 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 476213008415 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 476213008416 dimerization interface [polypeptide binding]; other site 476213008417 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 476213008418 dimer interface [polypeptide binding]; other site 476213008419 phosphorylation site [posttranslational modification] 476213008420 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 476213008421 ATP binding site [chemical binding]; other site 476213008422 Mg2+ binding site [ion binding]; other site 476213008423 G-X-G motif; other site 476213008424 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 476213008425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 476213008426 active site 476213008427 phosphorylation site [posttranslational modification] 476213008428 intermolecular recognition site; other site 476213008429 dimerization interface [polypeptide binding]; other site 476213008430 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 476213008431 putative binding surface; other site 476213008432 active site 476213008433 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 476213008434 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 476213008435 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 476213008436 active site 476213008437 tetramer interface [polypeptide binding]; other site 476213008438 flavodoxin; Provisional; Region: PRK08105 476213008439 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 476213008440 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 476213008441 probable active site [active] 476213008442 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 476213008443 SecY interacting protein Syd; Provisional; Region: PRK04968 476213008444 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 476213008445 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 476213008446 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 476213008447 Domain of unknown function (DUF4478); Region: DUF4478; pfam14793 476213008448 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 476213008449 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 476213008450 L-serine dehydratase TdcG; Provisional; Region: PRK15040 476213008451 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 476213008452 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 476213008453 flap endonuclease-like protein; Provisional; Region: PRK09482 476213008454 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 476213008455 active site 476213008456 metal binding site 1 [ion binding]; metal-binding site 476213008457 putative 5' ssDNA interaction site; other site 476213008458 metal binding site 3; metal-binding site 476213008459 metal binding site 2 [ion binding]; metal-binding site 476213008460 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 476213008461 putative DNA binding site [nucleotide binding]; other site 476213008462 putative metal binding site [ion binding]; other site 476213008463 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 476213008464 dimer interface [polypeptide binding]; other site 476213008465 active site 476213008466 metal binding site [ion binding]; metal-binding site 476213008467 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 476213008468 intersubunit interface [polypeptide binding]; other site 476213008469 active site 476213008470 Zn2+ binding site [ion binding]; other site 476213008471 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 476213008472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213008473 putative substrate translocation pore; other site 476213008474 L-fucose isomerase; Provisional; Region: fucI; PRK10991 476213008475 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 476213008476 hexamer (dimer of trimers) interface [polypeptide binding]; other site 476213008477 trimer interface [polypeptide binding]; other site 476213008478 substrate binding site [chemical binding]; other site 476213008479 Mn binding site [ion binding]; other site 476213008480 L-fuculokinase; Provisional; Region: PRK10331 476213008481 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 476213008482 nucleotide binding site [chemical binding]; other site 476213008483 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 476213008484 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 476213008485 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 476213008486 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 476213008487 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 476213008488 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 476213008489 hypothetical protein; Provisional; Region: PRK10873 476213008490 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 476213008491 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213008492 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 476213008493 dimerization interface [polypeptide binding]; other site 476213008494 substrate binding pocket [chemical binding]; other site 476213008495 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 476213008496 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 476213008497 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 476213008498 catalytic residue [active] 476213008499 CsdA-binding activator; Provisional; Region: PRK15019 476213008500 Predicted permeases [General function prediction only]; Region: RarD; COG2962 476213008501 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 476213008502 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 476213008503 putative ATP binding site [chemical binding]; other site 476213008504 putative substrate interface [chemical binding]; other site 476213008505 murein transglycosylase A; Provisional; Region: mltA; PRK11162 476213008506 MltA specific insert domain; Region: MltA; smart00925 476213008507 3D domain; Region: 3D; pfam06725 476213008508 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 476213008509 AMIN domain; Region: AMIN; pfam11741 476213008510 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 476213008511 active site 476213008512 metal binding site [ion binding]; metal-binding site 476213008513 N-acetylglutamate synthase; Validated; Region: PRK05279 476213008514 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 476213008515 putative feedback inhibition sensing region; other site 476213008516 putative nucleotide binding site [chemical binding]; other site 476213008517 putative substrate binding site [chemical binding]; other site 476213008518 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 476213008519 Coenzyme A binding pocket [chemical binding]; other site 476213008520 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 476213008521 AAA domain; Region: AAA_30; pfam13604 476213008522 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 476213008523 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 476213008524 Protein of unknown function (DUF770); Region: DUF770; cl01402 476213008525 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 476213008526 protease3; Provisional; Region: PRK15101 476213008527 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 476213008528 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 476213008529 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 476213008530 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 476213008531 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 476213008532 hypothetical protein; Provisional; Region: PRK10332 476213008533 hypothetical protein; Provisional; Region: PRK11521 476213008534 hypothetical protein; Provisional; Region: PRK10557 476213008535 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 476213008536 hypothetical protein; Provisional; Region: PRK10506 476213008537 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 476213008538 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 476213008539 dimerization interface [polypeptide binding]; other site 476213008540 active site 476213008541 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 476213008542 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 476213008543 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 476213008544 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 476213008545 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 476213008546 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 476213008547 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 476213008548 putative active site [active] 476213008549 Ap4A binding site [chemical binding]; other site 476213008550 nudix motif; other site 476213008551 putative metal binding site [ion binding]; other site 476213008552 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 476213008553 putative DNA-binding cleft [nucleotide binding]; other site 476213008554 putative DNA clevage site; other site 476213008555 molecular lever; other site 476213008556 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 476213008557 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 476213008558 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 476213008559 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 476213008560 active site 476213008561 catalytic tetrad [active] 476213008562 lysophospholipid transporter LplT; Provisional; Region: PRK11195 476213008563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213008564 putative substrate translocation pore; other site 476213008565 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 476213008566 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 476213008567 putative acyl-acceptor binding pocket; other site 476213008568 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 476213008569 acyl-activating enzyme (AAE) consensus motif; other site 476213008570 putative AMP binding site [chemical binding]; other site 476213008571 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 476213008572 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 476213008573 DNA binding site [nucleotide binding] 476213008574 domain linker motif; other site 476213008575 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 476213008576 dimerization interface (closed form) [polypeptide binding]; other site 476213008577 ligand binding site [chemical binding]; other site 476213008578 Transcriptional regulators [Transcription]; Region: PurR; COG1609 476213008579 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 476213008580 DNA binding site [nucleotide binding] 476213008581 domain linker motif; other site 476213008582 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 476213008583 dimerization interface (closed form) [polypeptide binding]; other site 476213008584 ligand binding site [chemical binding]; other site 476213008585 diaminopimelate decarboxylase; Provisional; Region: PRK11165 476213008586 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 476213008587 active site 476213008588 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 476213008589 substrate binding site [chemical binding]; other site 476213008590 catalytic residues [active] 476213008591 dimer interface [polypeptide binding]; other site 476213008592 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 476213008593 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213008594 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 476213008595 dimerization interface [polypeptide binding]; other site 476213008596 putative racemase; Provisional; Region: PRK10200 476213008597 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 476213008598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213008599 putative substrate translocation pore; other site 476213008600 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 476213008601 short chain dehydrogenase; Region: adh_short; pfam00106 476213008602 NAD(P) binding site [chemical binding]; other site 476213008603 active site 476213008604 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 476213008605 putative acyltransferase; Provisional; Region: PRK05790 476213008606 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 476213008607 dimer interface [polypeptide binding]; other site 476213008608 active site 476213008609 Transcriptional regulator [Transcription]; Region: LysR; COG0583 476213008610 LysR substrate binding domain; Region: LysR_substrate; pfam03466 476213008611 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 476213008612 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 476213008613 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 476213008614 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 476213008615 putative metal binding site [ion binding]; other site 476213008616 putative homodimer interface [polypeptide binding]; other site 476213008617 putative homotetramer interface [polypeptide binding]; other site 476213008618 putative homodimer-homodimer interface [polypeptide binding]; other site 476213008619 putative allosteric switch controlling residues; other site 476213008620 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 476213008621 transcriptional activator SprB; Provisional; Region: PRK15320 476213008622 Protein of unknown function (DUF1401); Region: DUF1401; pfam07180 476213008623 Fimbrial protein; Region: Fimbrial; pfam00419 476213008624 fimbrial chaperone protein StdC; Provisional; Region: PRK15254 476213008625 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 476213008626 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 476213008627 fimbrial outer membrane usher protein StdB; Provisional; Region: PRK15255 476213008628 PapC N-terminal domain; Region: PapC_N; pfam13954 476213008629 Outer membrane usher protein; Region: Usher; pfam00577 476213008630 PapC C-terminal domain; Region: PapC_C; pfam13953 476213008631 fimbrial protein StdA; Provisional; Region: PRK15210 476213008632 hypothetical protein; Provisional; Region: PRK10316 476213008633 YfdX protein; Region: YfdX; pfam10938 476213008634 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 476213008635 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 476213008636 oligomeric interface; other site 476213008637 putative active site [active] 476213008638 homodimer interface [polypeptide binding]; other site 476213008639 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 476213008640 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 476213008641 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 476213008642 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 476213008643 Peptidase family M23; Region: Peptidase_M23; pfam01551 476213008644 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 476213008645 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 476213008646 active site 476213008647 metal binding site [ion binding]; metal-binding site 476213008648 nudix motif; other site 476213008649 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 476213008650 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 476213008651 dimer interface [polypeptide binding]; other site 476213008652 putative anticodon binding site; other site 476213008653 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 476213008654 motif 1; other site 476213008655 active site 476213008656 motif 2; other site 476213008657 motif 3; other site 476213008658 peptide chain release factor 2; Provisional; Region: PRK08787 476213008659 This domain is found in peptide chain release factors; Region: PCRF; smart00937 476213008660 RF-1 domain; Region: RF-1; pfam00472 476213008661 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 476213008662 DHH family; Region: DHH; pfam01368 476213008663 DHHA1 domain; Region: DHHA1; pfam02272 476213008664 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 476213008665 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 476213008666 dimerization domain [polypeptide binding]; other site 476213008667 dimer interface [polypeptide binding]; other site 476213008668 catalytic residues [active] 476213008669 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 476213008670 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 476213008671 active site 476213008672 Int/Topo IB signature motif; other site 476213008673 flavodoxin FldB; Provisional; Region: PRK12359 476213008674 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 476213008675 hypothetical protein; Provisional; Region: PRK10878 476213008676 putative global regulator; Reviewed; Region: PRK09559 476213008677 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 476213008678 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 476213008679 hemolysin; Provisional; Region: PRK15087 476213008680 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 476213008681 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 476213008682 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 476213008683 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 476213008684 glycine dehydrogenase; Provisional; Region: PRK05367 476213008685 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 476213008686 tetramer interface [polypeptide binding]; other site 476213008687 pyridoxal 5'-phosphate binding site [chemical binding]; other site 476213008688 catalytic residue [active] 476213008689 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 476213008690 tetramer interface [polypeptide binding]; other site 476213008691 pyridoxal 5'-phosphate binding site [chemical binding]; other site 476213008692 catalytic residue [active] 476213008693 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 476213008694 lipoyl attachment site [posttranslational modification]; other site 476213008695 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 476213008696 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 476213008697 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 476213008698 oxidoreductase; Provisional; Region: PRK08013 476213008699 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 476213008700 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 476213008701 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 476213008702 proline aminopeptidase P II; Provisional; Region: PRK10879 476213008703 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 476213008704 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 476213008705 active site 476213008706 hypothetical protein; Reviewed; Region: PRK01736 476213008707 Z-ring-associated protein; Provisional; Region: PRK10972 476213008708 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 476213008709 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 476213008710 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 476213008711 ligand binding site [chemical binding]; other site 476213008712 NAD binding site [chemical binding]; other site 476213008713 tetramer interface [polypeptide binding]; other site 476213008714 catalytic site [active] 476213008715 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 476213008716 L-serine binding site [chemical binding]; other site 476213008717 ACT domain interface; other site 476213008718 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 476213008719 tetramer (dimer of dimers) interface [polypeptide binding]; other site 476213008720 active site 476213008721 dimer interface [polypeptide binding]; other site 476213008722 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 476213008723 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213008724 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 476213008725 putative dimerization interface [polypeptide binding]; other site 476213008726 oxidative stress defense protein; Provisional; Region: PRK11087 476213008727 arginine exporter protein; Provisional; Region: PRK09304 476213008728 mechanosensitive channel MscS; Provisional; Region: PRK10334 476213008729 Mechanosensitive ion channel; Region: MS_channel; pfam00924 476213008730 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 476213008731 active site 476213008732 intersubunit interface [polypeptide binding]; other site 476213008733 zinc binding site [ion binding]; other site 476213008734 Na+ binding site [ion binding]; other site 476213008735 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 476213008736 substrate binding site [chemical binding]; other site 476213008737 hinge regions; other site 476213008738 ADP binding site [chemical binding]; other site 476213008739 catalytic site [active] 476213008740 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 476213008741 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 476213008742 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 476213008743 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 476213008744 trimer interface [polypeptide binding]; other site 476213008745 putative Zn binding site [ion binding]; other site 476213008746 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 476213008747 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 476213008748 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 476213008749 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 476213008750 Walker A/P-loop; other site 476213008751 ATP binding site [chemical binding]; other site 476213008752 Q-loop/lid; other site 476213008753 ABC transporter signature motif; other site 476213008754 Walker B; other site 476213008755 D-loop; other site 476213008756 H-loop/switch region; other site 476213008757 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 476213008758 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 476213008759 Walker A/P-loop; other site 476213008760 ATP binding site [chemical binding]; other site 476213008761 Q-loop/lid; other site 476213008762 ABC transporter signature motif; other site 476213008763 Walker B; other site 476213008764 D-loop; other site 476213008765 H-loop/switch region; other site 476213008766 transketolase; Reviewed; Region: PRK12753 476213008767 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 476213008768 TPP-binding site [chemical binding]; other site 476213008769 dimer interface [polypeptide binding]; other site 476213008770 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 476213008771 PYR/PP interface [polypeptide binding]; other site 476213008772 dimer interface [polypeptide binding]; other site 476213008773 TPP binding site [chemical binding]; other site 476213008774 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 476213008775 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 476213008776 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 476213008777 oligomer interface [polypeptide binding]; other site 476213008778 putative active site [active] 476213008779 Mn binding site [ion binding]; other site 476213008780 Putative lysophospholipase; Region: Hydrolase_4; cl19140 476213008781 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 476213008782 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 476213008783 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 476213008784 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 476213008785 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 476213008786 putative NAD(P) binding site [chemical binding]; other site 476213008787 catalytic Zn binding site [ion binding]; other site 476213008788 structural Zn binding site [ion binding]; other site 476213008789 Transcriptional regulators [Transcription]; Region: FadR; COG2186 476213008790 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 476213008791 DNA-binding site [nucleotide binding]; DNA binding site 476213008792 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 476213008793 DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237 476213008794 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 476213008795 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 476213008796 dimer interface [polypeptide binding]; other site 476213008797 active site 476213008798 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 476213008799 catalytic residues [active] 476213008800 substrate binding site [chemical binding]; other site 476213008801 Virulence promoting factor; Region: YqgB; pfam11036 476213008802 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 476213008803 potential protein location (hypothetical protein) that overlaps protein ( inner membrane protein) 476213008804 S-adenosylmethionine synthetase; Validated; Region: PRK05250 476213008805 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 476213008806 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 476213008807 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 476213008808 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 476213008809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213008810 putative substrate translocation pore; other site 476213008811 hypothetical protein; Provisional; Region: PRK04860 476213008812 DNA-specific endonuclease I; Provisional; Region: PRK15137 476213008813 RNA methyltransferase, RsmE family; Region: TIGR00046 476213008814 glutathione synthetase; Provisional; Region: PRK05246 476213008815 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 476213008816 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 476213008817 hypothetical protein; Validated; Region: PRK00228 476213008818 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 476213008819 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 476213008820 Transcriptional regulator [Transcription]; Region: IclR; COG1414 476213008821 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 476213008822 Walker A motif; other site 476213008823 ATP binding site [chemical binding]; other site 476213008824 Walker B motif; other site 476213008825 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 476213008826 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 476213008827 catalytic residue [active] 476213008828 YGGT family; Region: YGGT; pfam02325 476213008829 Predicted integral membrane protein [Function unknown]; Region: COG0762 476213008830 hypothetical protein; Validated; Region: PRK05090 476213008831 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 476213008832 active site 476213008833 dimerization interface [polypeptide binding]; other site 476213008834 HemN family oxidoreductase; Provisional; Region: PRK05660 476213008835 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 476213008836 FeS/SAM binding site; other site 476213008837 HemN C-terminal domain; Region: HemN_C; pfam06969 476213008838 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 476213008839 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 476213008840 active site 476213008841 homodimer interface [polypeptide binding]; other site 476213008842 hypothetical protein; Provisional; Region: PRK10626 476213008843 hypothetical protein; Provisional; Region: PRK11702 476213008844 Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220 476213008845 adenine DNA glycosylase; Provisional; Region: PRK10880 476213008846 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 476213008847 minor groove reading motif; other site 476213008848 helix-hairpin-helix signature motif; other site 476213008849 substrate binding pocket [chemical binding]; other site 476213008850 active site 476213008851 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 476213008852 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 476213008853 DNA binding and oxoG recognition site [nucleotide binding] 476213008854 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2924 476213008855 murein transglycosylase C; Provisional; Region: mltC; PRK11671 476213008856 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 476213008857 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 476213008858 N-acetyl-D-glucosamine binding site [chemical binding]; other site 476213008859 catalytic residue [active] 476213008860 nucleoside transporter; Region: 2A0110; TIGR00889 476213008861 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 476213008862 ornithine decarboxylase; Provisional; Region: PRK13578 476213008863 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 476213008864 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 476213008865 homodimer interface [polypeptide binding]; other site 476213008866 pyridoxal 5'-phosphate binding site [chemical binding]; other site 476213008867 catalytic residue [active] 476213008868 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 476213008869 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 476213008870 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 476213008871 dimer interface [polypeptide binding]; other site 476213008872 metal binding site [ion binding]; metal-binding site 476213008873 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 476213008874 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 476213008875 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 476213008876 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 476213008877 putative active site [active] 476213008878 putative catalytic site [active] 476213008879 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 476213008880 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 476213008881 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213008882 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 476213008883 putative dimerization interface [polypeptide binding]; other site 476213008884 putative substrate binding pocket [chemical binding]; other site 476213008885 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 476213008886 Sulfatase; Region: Sulfatase; pfam00884 476213008887 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 476213008888 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 476213008889 FeS/SAM binding site; other site 476213008890 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 476213008891 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 476213008892 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 476213008893 DNA binding residues [nucleotide binding] 476213008894 dimerization interface [polypeptide binding]; other site 476213008895 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 476213008896 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 476213008897 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 476213008898 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 476213008899 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 476213008900 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 476213008901 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 476213008902 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 476213008903 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 476213008904 active site 476213008905 catalytic site [active] 476213008906 Zn binding site [ion binding]; other site 476213008907 tetramer interface [polypeptide binding]; other site 476213008908 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 476213008909 putative active site [active] 476213008910 catalytic triad [active] 476213008911 putative dimer interface [polypeptide binding]; other site 476213008912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213008913 D-galactonate transporter; Region: 2A0114; TIGR00893 476213008914 putative substrate translocation pore; other site 476213008915 mannonate dehydratase; Provisional; Region: PRK03906 476213008916 mannonate dehydratase; Region: uxuA; TIGR00695 476213008917 D-mannonate oxidoreductase; Provisional; Region: PRK15037 476213008918 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 476213008919 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 476213008920 glucuronate isomerase; Reviewed; Region: PRK02925 476213008921 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 476213008922 dimer interface [polypeptide binding]; other site 476213008923 putative CheW interface [polypeptide binding]; other site 476213008924 Chemoreceptor zinc-binding domain; Region: CZB; pfam13682 476213008925 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 476213008926 CHAP domain; Region: CHAP; pfam05257 476213008927 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 476213008928 putative S-transferase; Provisional; Region: PRK11752 476213008929 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 476213008930 C-terminal domain interface [polypeptide binding]; other site 476213008931 GSH binding site (G-site) [chemical binding]; other site 476213008932 dimer interface [polypeptide binding]; other site 476213008933 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 476213008934 dimer interface [polypeptide binding]; other site 476213008935 N-terminal domain interface [polypeptide binding]; other site 476213008936 active site 476213008937 molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537 476213008938 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 476213008939 putative ligand binding residues [chemical binding]; other site 476213008940 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 476213008941 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 476213008942 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 476213008943 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 476213008944 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 476213008945 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 476213008946 putative substrate-binding site; other site 476213008947 nickel binding site [ion binding]; other site 476213008948 hydrogenase 2 large subunit; Provisional; Region: PRK10467 476213008949 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 476213008950 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 476213008951 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 476213008952 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 476213008953 hydrogenase 2 small subunit; Provisional; Region: PRK10468 476213008954 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 476213008955 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 476213008956 NiFe/NiFeSe hydrogenase small subunit C-terminal; Region: NiFe_hyd_SSU_C; pfam14720 476213008957 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 476213008958 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 476213008959 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 476213008960 dimerization interface [polypeptide binding]; other site 476213008961 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 476213008962 dimer interface [polypeptide binding]; other site 476213008963 putative CheW interface [polypeptide binding]; other site 476213008964 hypothetical protein; Provisional; Region: PRK05208 476213008965 oxidoreductase; Provisional; Region: PRK07985 476213008966 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 476213008967 NAD binding site [chemical binding]; other site 476213008968 metal binding site [ion binding]; metal-binding site 476213008969 active site 476213008970 biopolymer transport protein ExbD; Provisional; Region: PRK11267 476213008971 biopolymer transport protein ExbB; Provisional; Region: PRK10414 476213008972 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 476213008973 Helix-turn-helix domain; Region: HTH_28; pfam13518 476213008974 Integrase core domain; Region: rve; pfam00665 476213008975 Integrase core domain; Region: rve_3; pfam13683 476213008976 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 476213008977 homodimer interface [polypeptide binding]; other site 476213008978 substrate-cofactor binding pocket; other site 476213008979 pyridoxal 5'-phosphate binding site [chemical binding]; other site 476213008980 catalytic residue [active] 476213008981 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 476213008982 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 476213008983 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 476213008984 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213008985 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213008986 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 476213008987 dimer interface [polypeptide binding]; other site 476213008988 active site 476213008989 metal binding site [ion binding]; metal-binding site 476213008990 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 476213008991 active site 476213008992 catalytic tetrad [active] 476213008993 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 476213008994 anion transporter; Region: dass; TIGR00785 476213008995 transmembrane helices; other site 476213008996 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 476213008997 catalytic residue [active] 476213008998 hypothetical protein; Provisional; Region: PRK01254 476213008999 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 476213009000 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 476213009001 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 476213009002 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 476213009003 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 476213009004 DctM-like transporters; Region: DctM; pfam06808 476213009005 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 476213009006 FtsI repressor; Provisional; Region: PRK10883 476213009007 Sulfur oxidation protein SoxY; Region: SoxY; cl19207 476213009008 The first Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_1_CueO_FtsP; cd04232 476213009009 Domain 2 interface [polypeptide binding]; other site 476213009010 Domain 3 interface [polypeptide binding]; other site 476213009011 trinuclear Cu binding site [ion binding]; other site 476213009012 The second Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_2_CueO_FtsP; cd13867 476213009013 Domain 1 interface [polypeptide binding]; other site 476213009014 Domain 3 interface [polypeptide binding]; other site 476213009015 The third Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_3_CueO_FtsP; cd13890 476213009016 Domain 2 interface [polypeptide binding]; other site 476213009017 Domain 1 interface [polypeptide binding]; other site 476213009018 Type 1 (T1) Cu binding site [ion binding]; other site 476213009019 trinuclear Cu binding site [ion binding]; other site 476213009020 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 476213009021 putative acyl-acceptor binding pocket; other site 476213009022 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 476213009023 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 476213009024 CAP-like domain; other site 476213009025 active site 476213009026 primary dimer interface [polypeptide binding]; other site 476213009027 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 476213009028 Helix-turn-helix domain; Region: HTH_18; pfam12833 476213009029 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213009030 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 476213009031 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 476213009032 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 476213009033 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 476213009034 active site 476213009035 phosphorylation site [posttranslational modification] 476213009036 intermolecular recognition site; other site 476213009037 dimerization interface [polypeptide binding]; other site 476213009038 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 476213009039 DNA binding site [nucleotide binding] 476213009040 sensor protein QseC; Provisional; Region: PRK10337 476213009041 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 476213009042 dimer interface [polypeptide binding]; other site 476213009043 phosphorylation site [posttranslational modification] 476213009044 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 476213009045 ATP binding site [chemical binding]; other site 476213009046 Mg2+ binding site [ion binding]; other site 476213009047 G-X-G motif; other site 476213009048 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 476213009049 Uncharacterized conserved protein [Function unknown]; Region: COG1359 476213009050 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 476213009051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 476213009052 ATP binding site [chemical binding]; other site 476213009053 Mg2+ binding site [ion binding]; other site 476213009054 G-X-G motif; other site 476213009055 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 476213009056 anchoring element; other site 476213009057 dimer interface [polypeptide binding]; other site 476213009058 ATP binding site [chemical binding]; other site 476213009059 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 476213009060 active site 476213009061 metal binding site [ion binding]; metal-binding site 476213009062 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 476213009063 esterase YqiA; Provisional; Region: PRK11071 476213009064 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 476213009065 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 476213009066 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 476213009067 active site 476213009068 metal binding site [ion binding]; metal-binding site 476213009069 hexamer interface [polypeptide binding]; other site 476213009070 putative dehydrogenase; Provisional; Region: PRK11039 476213009071 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 476213009072 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 476213009073 dimer interface [polypeptide binding]; other site 476213009074 ADP-ribose binding site [chemical binding]; other site 476213009075 active site 476213009076 nudix motif; other site 476213009077 metal binding site [ion binding]; metal-binding site 476213009078 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 476213009079 Outer membrane efflux protein; Region: OEP; pfam02321 476213009080 Outer membrane efflux protein; Region: OEP; pfam02321 476213009081 hypothetical protein; Provisional; Region: PRK11653 476213009082 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 476213009083 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 476213009084 putative active site [active] 476213009085 metal binding site [ion binding]; metal-binding site 476213009086 zinc transporter ZupT; Provisional; Region: PRK04201 476213009087 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 476213009088 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 476213009089 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 476213009090 catalytic residues [active] 476213009091 hinge region; other site 476213009092 alpha helical domain; other site 476213009093 putative disulfide oxidoreductase; Provisional; Region: PRK04307 476213009094 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 476213009095 Helix-turn-helix domain; Region: HTH_28; pfam13518 476213009096 Integrase core domain; Region: rve; pfam00665 476213009097 Integrase core domain; Region: rve_3; pfam13683 476213009098 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 476213009099 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 476213009100 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 476213009101 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 476213009102 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 476213009103 Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_flotillin; cd03399 476213009104 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 476213009105 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 476213009106 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 476213009107 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 476213009108 putative ribose interaction site [chemical binding]; other site 476213009109 putative ADP binding site [chemical binding]; other site 476213009110 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 476213009111 active site 476213009112 nucleotide binding site [chemical binding]; other site 476213009113 HIGH motif; other site 476213009114 KMSKS motif; other site 476213009115 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 476213009116 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 476213009117 metal binding triad; other site 476213009118 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 476213009119 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 476213009120 metal binding triad; other site 476213009121 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; cl19627 476213009122 Uncharacterized conserved protein [Function unknown]; Region: COG3025 476213009123 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 476213009124 putative active site [active] 476213009125 putative metal binding residues [ion binding]; other site 476213009126 signature motif; other site 476213009127 putative triphosphate binding site [ion binding]; other site 476213009128 CHAD domain; Region: CHAD; pfam05235 476213009129 SH3 domain-containing protein; Provisional; Region: PRK10884 476213009130 Bacterial SH3 domain homologues; Region: SH3b; smart00287 476213009131 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 476213009132 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 476213009133 active site 476213009134 NTP binding site [chemical binding]; other site 476213009135 metal binding triad [ion binding]; metal-binding site 476213009136 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 476213009137 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 476213009138 Zn2+ binding site [ion binding]; other site 476213009139 Mg2+ binding site [ion binding]; other site 476213009140 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 476213009141 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 476213009142 homooctamer interface [polypeptide binding]; other site 476213009143 active site 476213009144 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 476213009145 UGMP family protein; Validated; Region: PRK09604 476213009146 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 476213009147 nucleotide binding site [chemical binding]; other site 476213009148 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 476213009149 DNA primase; Validated; Region: dnaG; PRK05667 476213009150 CHC2 zinc finger; Region: zf-CHC2; pfam01807 476213009151 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 476213009152 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 476213009153 active site 476213009154 metal binding site [ion binding]; metal-binding site 476213009155 interdomain interaction site; other site 476213009156 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 476213009157 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 476213009158 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 476213009159 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 476213009160 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 476213009161 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 476213009162 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 476213009163 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 476213009164 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 476213009165 DNA binding residues [nucleotide binding] 476213009166 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 476213009167 active site 476213009168 SUMO-1 interface [polypeptide binding]; other site 476213009169 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 476213009170 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 476213009171 FAD binding pocket [chemical binding]; other site 476213009172 FAD binding motif [chemical binding]; other site 476213009173 phosphate binding motif [ion binding]; other site 476213009174 NAD binding pocket [chemical binding]; other site 476213009175 Predicted transcriptional regulators [Transcription]; Region: COG1695 476213009176 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 476213009177 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 476213009178 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 476213009179 dimerization interface [polypeptide binding]; other site 476213009180 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 476213009181 dimer interface [polypeptide binding]; other site 476213009182 putative CheW interface [polypeptide binding]; other site 476213009183 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 476213009184 PAS fold; Region: PAS_3; pfam08447 476213009185 putative active site [active] 476213009186 heme pocket [chemical binding]; other site 476213009187 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 476213009188 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 476213009189 dimer interface [polypeptide binding]; other site 476213009190 putative CheW interface [polypeptide binding]; other site 476213009191 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 476213009192 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 476213009193 inhibitor-cofactor binding pocket; inhibition site 476213009194 pyridoxal 5'-phosphate binding site [chemical binding]; other site 476213009195 catalytic residue [active] 476213009196 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 476213009197 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 476213009198 active site 476213009199 FMN binding site [chemical binding]; other site 476213009200 2,4-decadienoyl-CoA binding site; other site 476213009201 catalytic residue [active] 476213009202 4Fe-4S cluster binding site [ion binding]; other site 476213009203 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 476213009204 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 476213009205 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 476213009206 S-adenosylmethionine binding site [chemical binding]; other site 476213009207 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 476213009208 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 476213009209 putative active site [active] 476213009210 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 476213009211 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 476213009212 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 476213009213 serine/threonine transporter SstT; Provisional; Region: PRK13628 476213009214 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 476213009215 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 476213009216 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 476213009217 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 476213009218 Predicted membrane protein [Function unknown]; Region: COG5393 476213009219 YqjK-like protein; Region: YqjK; pfam13997 476213009220 Predicted membrane protein [Function unknown]; Region: COG2259 476213009221 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 476213009222 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 476213009223 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 476213009224 putative dimer interface [polypeptide binding]; other site 476213009225 N-terminal domain interface [polypeptide binding]; other site 476213009226 putative substrate binding pocket (H-site) [chemical binding]; other site 476213009227 Predicted membrane protein [Function unknown]; Region: COG3152 476213009228 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213009229 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 476213009230 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 476213009231 dimerization interface [polypeptide binding]; other site 476213009232 Pirin-related protein [General function prediction only]; Region: COG1741 476213009233 Pirin; Region: Pirin; pfam02678 476213009234 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 476213009235 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 476213009236 serine transporter; Region: stp; TIGR00814 476213009237 L-serine dehydratase TdcG; Provisional; Region: PRK15040 476213009238 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 476213009239 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 476213009240 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 476213009241 Pyruvate formate lyase 1; Region: PFL1; cd01678 476213009242 coenzyme A binding site [chemical binding]; other site 476213009243 active site 476213009244 catalytic residues [active] 476213009245 glycine loop; other site 476213009246 propionate/acetate kinase; Provisional; Region: PRK12379 476213009247 threonine/serine transporter TdcC; Provisional; Region: PRK13629 476213009248 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 476213009249 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 476213009250 tetramer interface [polypeptide binding]; other site 476213009251 pyridoxal 5'-phosphate binding site [chemical binding]; other site 476213009252 catalytic residue [active] 476213009253 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 476213009254 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213009255 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 476213009256 putative substrate binding pocket [chemical binding]; other site 476213009257 putative dimerization interface [polypeptide binding]; other site 476213009258 glycerate kinase I; Provisional; Region: PRK10342 476213009259 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 476213009260 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 476213009261 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 476213009262 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 476213009263 galactarate dehydratase; Region: galactar-dH20; TIGR03248 476213009264 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 476213009265 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 476213009266 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 476213009267 intersubunit interface [polypeptide binding]; other site 476213009268 active site 476213009269 zinc binding site [ion binding]; other site 476213009270 Na+ binding site [ion binding]; other site 476213009271 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 476213009272 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 476213009273 active site 476213009274 phosphorylation site [posttranslational modification] 476213009275 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 476213009276 active site 476213009277 P-loop; other site 476213009278 phosphorylation site [posttranslational modification] 476213009279 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 476213009280 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 476213009281 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 476213009282 putative NAD(P) binding site [chemical binding]; other site 476213009283 catalytic Zn binding site [ion binding]; other site 476213009284 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 476213009285 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 476213009286 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 476213009287 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 476213009288 putative SAM binding site [chemical binding]; other site 476213009289 putative homodimer interface [polypeptide binding]; other site 476213009290 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 476213009291 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 476213009292 putative ligand binding site [chemical binding]; other site 476213009293 TIGR00252 family protein; Region: TIGR00252 476213009294 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 476213009295 dimer interface [polypeptide binding]; other site 476213009296 active site 476213009297 outer membrane lipoprotein; Provisional; Region: PRK11023 476213009298 BON domain; Region: BON; pfam04972 476213009299 BON domain; Region: BON; pfam04972 476213009300 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 476213009301 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 476213009302 NAD(P) binding site [chemical binding]; other site 476213009303 active site 476213009304 intracellular protease, PfpI family; Region: PfpI; TIGR01382 476213009305 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 476213009306 proposed catalytic triad [active] 476213009307 conserved cys residue [active] 476213009308 hypothetical protein; Provisional; Region: PRK03467 476213009309 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 476213009310 GIY-YIG motif/motif A; other site 476213009311 putative active site [active] 476213009312 putative metal binding site [ion binding]; other site 476213009313 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 476213009314 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 476213009315 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 476213009316 Coenzyme A binding pocket [chemical binding]; other site 476213009317 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 476213009318 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 476213009319 putative protease; Provisional; Region: PRK15447 476213009320 hypothetical protein; Provisional; Region: PRK10508 476213009321 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 476213009322 tryptophan permease; Provisional; Region: PRK10483 476213009323 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 476213009324 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 476213009325 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 476213009326 ATP binding site [chemical binding]; other site 476213009327 Mg++ binding site [ion binding]; other site 476213009328 motif III; other site 476213009329 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 476213009330 nucleotide binding region [chemical binding]; other site 476213009331 ATP-binding site [chemical binding]; other site 476213009332 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 476213009333 putative RNA binding site [nucleotide binding]; other site 476213009334 Cold shock protein DEAD box A; Region: DEADboxA; pfam12343 476213009335 lipoprotein NlpI; Provisional; Region: PRK11189 476213009336 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 476213009337 binding surface 476213009338 TPR motif; other site 476213009339 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 476213009340 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 476213009341 RNase E interface [polypeptide binding]; other site 476213009342 trimer interface [polypeptide binding]; other site 476213009343 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 476213009344 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 476213009345 RNase E interface [polypeptide binding]; other site 476213009346 trimer interface [polypeptide binding]; other site 476213009347 active site 476213009348 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 476213009349 putative nucleic acid binding region [nucleotide binding]; other site 476213009350 G-X-X-G motif; other site 476213009351 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 476213009352 RNA binding site [nucleotide binding]; other site 476213009353 domain interface; other site 476213009354 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 476213009355 16S/18S rRNA binding site [nucleotide binding]; other site 476213009356 S13e-L30e interaction site [polypeptide binding]; other site 476213009357 25S rRNA binding site [nucleotide binding]; other site 476213009358 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 476213009359 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 476213009360 RNA binding site [nucleotide binding]; other site 476213009361 active site 476213009362 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 476213009363 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 476213009364 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 476213009365 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 476213009366 translation initiation factor IF-2; Validated; Region: infB; PRK05306 476213009367 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 476213009368 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 476213009369 G1 box; other site 476213009370 putative GEF interaction site [polypeptide binding]; other site 476213009371 GTP/Mg2+ binding site [chemical binding]; other site 476213009372 Switch I region; other site 476213009373 G2 box; other site 476213009374 G3 box; other site 476213009375 Switch II region; other site 476213009376 G4 box; other site 476213009377 G5 box; other site 476213009378 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 476213009379 Translation-initiation factor 2; Region: IF-2; pfam11987 476213009380 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 476213009381 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 476213009382 NusA N-terminal domain; Region: NusA_N; pfam08529 476213009383 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 476213009384 RNA binding site [nucleotide binding]; other site 476213009385 homodimer interface [polypeptide binding]; other site 476213009386 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 476213009387 G-X-X-G motif; other site 476213009388 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 476213009389 G-X-X-G motif; other site 476213009390 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 476213009391 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 476213009392 hypothetical protein; Provisional; Region: PRK14641 476213009393 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 476213009394 putative oligomer interface [polypeptide binding]; other site 476213009395 putative RNA binding site [nucleotide binding]; other site 476213009396 argininosuccinate synthase; Validated; Region: PRK05370 476213009397 Preprotein translocase SecG subunit; Region: SecG; pfam03840 476213009398 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 476213009399 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 476213009400 active site 476213009401 substrate binding site [chemical binding]; other site 476213009402 metal binding site [ion binding]; metal-binding site 476213009403 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 476213009404 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 476213009405 substrate binding pocket [chemical binding]; other site 476213009406 dimer interface [polypeptide binding]; other site 476213009407 inhibitor binding site; inhibition site 476213009408 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 476213009409 FtsH Extracellular; Region: FtsH_ext; pfam06480 476213009410 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 476213009411 Walker A motif; other site 476213009412 ATP binding site [chemical binding]; other site 476213009413 Walker B motif; other site 476213009414 arginine finger; other site 476213009415 Peptidase family M41; Region: Peptidase_M41; pfam01434 476213009416 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 476213009417 S-adenosylmethionine binding site [chemical binding]; other site 476213009418 RNA-binding protein YhbY; Provisional; Region: PRK10343 476213009419 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 476213009420 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 476213009421 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 476213009422 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 476213009423 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 476213009424 GTPase CgtA; Reviewed; Region: obgE; PRK12298 476213009425 GTP1/OBG; Region: GTP1_OBG; pfam01018 476213009426 Obg GTPase; Region: Obg; cd01898 476213009427 G1 box; other site 476213009428 GTP/Mg2+ binding site [chemical binding]; other site 476213009429 Switch I region; other site 476213009430 G2 box; other site 476213009431 G3 box; other site 476213009432 Switch II region; other site 476213009433 G4 box; other site 476213009434 G5 box; other site 476213009435 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 476213009436 EamA-like transporter family; Region: EamA; pfam00892 476213009437 EamA-like transporter family; Region: EamA; pfam00892 476213009438 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 476213009439 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 476213009440 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 476213009441 substrate binding pocket [chemical binding]; other site 476213009442 chain length determination region; other site 476213009443 substrate-Mg2+ binding site; other site 476213009444 catalytic residues [active] 476213009445 aspartate-rich region 1; other site 476213009446 active site lid residues [active] 476213009447 aspartate-rich region 2; other site 476213009448 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 476213009449 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 476213009450 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 476213009451 hinge; other site 476213009452 active site 476213009453 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 476213009454 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 476213009455 anti sigma factor interaction site; other site 476213009456 regulatory phosphorylation site [posttranslational modification]; other site 476213009457 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 476213009458 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 476213009459 mce related protein; Region: MCE; pfam02470 476213009460 conserved hypothetical integral membrane protein; Region: TIGR00056 476213009461 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 476213009462 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 476213009463 Walker A/P-loop; other site 476213009464 ATP binding site [chemical binding]; other site 476213009465 Q-loop/lid; other site 476213009466 ABC transporter signature motif; other site 476213009467 Walker B; other site 476213009468 D-loop; other site 476213009469 H-loop/switch region; other site 476213009470 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 476213009471 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 476213009472 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 476213009473 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 476213009474 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 476213009475 putative active site [active] 476213009476 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 476213009477 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 476213009478 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 476213009479 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 476213009480 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 476213009481 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 476213009482 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 476213009483 Walker A/P-loop; other site 476213009484 ATP binding site [chemical binding]; other site 476213009485 Q-loop/lid; other site 476213009486 ABC transporter signature motif; other site 476213009487 Walker B; other site 476213009488 D-loop; other site 476213009489 H-loop/switch region; other site 476213009490 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 476213009491 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 476213009492 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 476213009493 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 476213009494 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 476213009495 30S subunit binding site; other site 476213009496 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 476213009497 active site 476213009498 phosphorylation site [posttranslational modification] 476213009499 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 476213009500 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 476213009501 dimerization domain swap beta strand [polypeptide binding]; other site 476213009502 regulatory protein interface [polypeptide binding]; other site 476213009503 active site 476213009504 regulatory phosphorylation site [posttranslational modification]; other site 476213009505 hypothetical protein; Provisional; Region: PRK10345 476213009506 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 476213009507 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 476213009508 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 476213009509 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 476213009510 conserved cys residue [active] 476213009511 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 476213009512 Prefoldin subunit; Region: Prefoldin_2; pfam01920 476213009513 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 476213009514 putative active site [active] 476213009515 heme pocket [chemical binding]; other site 476213009516 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 476213009517 dimer interface [polypeptide binding]; other site 476213009518 phosphorylation site [posttranslational modification] 476213009519 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 476213009520 ATP binding site [chemical binding]; other site 476213009521 Mg2+ binding site [ion binding]; other site 476213009522 G-X-G motif; other site 476213009523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 476213009524 active site 476213009525 phosphorylation site [posttranslational modification] 476213009526 intermolecular recognition site; other site 476213009527 dimerization interface [polypeptide binding]; other site 476213009528 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 476213009529 putative binding surface; other site 476213009530 active site 476213009531 radical SAM protein, TIGR01212 family; Region: TIGR01212 476213009532 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 476213009533 FeS/SAM binding site; other site 476213009534 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 476213009535 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 476213009536 active site 476213009537 dimer interface [polypeptide binding]; other site 476213009538 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 476213009539 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 476213009540 active site 476213009541 FMN binding site [chemical binding]; other site 476213009542 substrate binding site [chemical binding]; other site 476213009543 3Fe-4S cluster binding site [ion binding]; other site 476213009544 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 476213009545 domain interface; other site 476213009546 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 476213009547 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 476213009548 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 476213009549 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 476213009550 Protein of unknown function (DUF1016); Region: DUF1016; cl19557 476213009551 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 476213009552 Na binding site [ion binding]; other site 476213009553 putative substrate binding site [chemical binding]; other site 476213009554 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 476213009555 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 476213009556 active site 476213009557 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 476213009558 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 476213009559 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 476213009560 nucleotide binding site [chemical binding]; other site 476213009561 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 476213009562 putative active site cavity [active] 476213009563 putative sialic acid transporter; Provisional; Region: PRK03893 476213009564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213009565 putative substrate translocation pore; other site 476213009566 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 476213009567 inhibitor site; inhibition site 476213009568 active site 476213009569 dimer interface [polypeptide binding]; other site 476213009570 catalytic residue [active] 476213009571 transcriptional regulator NanR; Provisional; Region: PRK03837 476213009572 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 476213009573 DNA-binding site [nucleotide binding]; DNA binding site 476213009574 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 476213009575 Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969 476213009576 stringent starvation protein A; Provisional; Region: sspA; PRK09481 476213009577 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 476213009578 C-terminal domain interface [polypeptide binding]; other site 476213009579 putative GSH binding site (G-site) [chemical binding]; other site 476213009580 dimer interface [polypeptide binding]; other site 476213009581 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 476213009582 dimer interface [polypeptide binding]; other site 476213009583 N-terminal domain interface [polypeptide binding]; other site 476213009584 Family of unknown function (DUF695); Region: DUF695; pfam05117 476213009585 Regulator of ribonuclease activity B; Region: RraB; pfam06877 476213009586 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 476213009587 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 476213009588 23S rRNA interface [nucleotide binding]; other site 476213009589 L3 interface [polypeptide binding]; other site 476213009590 Predicted ATPase [General function prediction only]; Region: COG1485 476213009591 hypothetical protein; Provisional; Region: PRK11677 476213009592 serine endoprotease; Provisional; Region: PRK10139 476213009593 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 476213009594 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 476213009595 protein binding site [polypeptide binding]; other site 476213009596 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 476213009597 serine endoprotease; Provisional; Region: PRK10898 476213009598 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 476213009599 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 476213009600 protein binding site [polypeptide binding]; other site 476213009601 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 476213009602 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15477 476213009603 oxaloacetate decarboxylase; Provisional; Region: PRK14040 476213009604 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 476213009605 active site 476213009606 catalytic residues [active] 476213009607 metal binding site [ion binding]; metal-binding site 476213009608 homodimer binding site [polypeptide binding]; other site 476213009609 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 476213009610 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 476213009611 carboxyltransferase (CT) interaction site; other site 476213009612 biotinylation site [posttranslational modification]; other site 476213009613 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 476213009614 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 476213009615 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 476213009616 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 476213009617 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 476213009618 transmembrane helices; other site 476213009619 Transcriptional regulators [Transcription]; Region: GntR; COG1802 476213009620 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 476213009621 DNA-binding site [nucleotide binding]; DNA binding site 476213009622 FCD domain; Region: FCD; pfam07729 476213009623 Transcriptional regulators [Transcription]; Region: GntR; COG1802 476213009624 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 476213009625 DNA-binding site [nucleotide binding]; DNA binding site 476213009626 malate dehydrogenase; Provisional; Region: PRK05086 476213009627 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 476213009628 NAD binding site [chemical binding]; other site 476213009629 dimerization interface [polypeptide binding]; other site 476213009630 Substrate binding site [chemical binding]; other site 476213009631 arginine repressor; Provisional; Region: PRK05066 476213009632 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 476213009633 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 476213009634 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 476213009635 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 476213009636 Barstar, RNAse (barnase) inhibitor [Transcription]; Region: COG2732 476213009637 RNAase interaction site [polypeptide binding]; other site 476213009638 Predicted membrane protein [Function unknown]; Region: COG1289 476213009639 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 476213009640 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 476213009641 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 476213009642 HlyD family secretion protein; Region: HlyD_3; pfam13437 476213009643 efflux system membrane protein; Provisional; Region: PRK11594 476213009644 transcriptional regulator; Provisional; Region: PRK10632 476213009645 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213009646 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 476213009647 putative effector binding pocket; other site 476213009648 dimerization interface [polypeptide binding]; other site 476213009649 protease TldD; Provisional; Region: tldD; PRK10735 476213009650 hypothetical protein; Provisional; Region: PRK10899 476213009651 Protein of unknown function; Region: DUF3971; pfam13116 476213009652 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 476213009653 ribonuclease G; Provisional; Region: PRK11712 476213009654 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 476213009655 homodimer interface [polypeptide binding]; other site 476213009656 oligonucleotide binding site [chemical binding]; other site 476213009657 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 476213009658 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 476213009659 active site 476213009660 dimer interface [polypeptide binding]; other site 476213009661 rod shape-determining protein MreD; Provisional; Region: PRK11060 476213009662 rod shape-determining protein MreC; Region: mreC; TIGR00219 476213009663 rod shape-determining protein MreB; Provisional; Region: PRK13927 476213009664 MreB and similar proteins; Region: MreB_like; cd10225 476213009665 nucleotide binding site [chemical binding]; other site 476213009666 Mg binding site [ion binding]; other site 476213009667 putative protofilament interaction site [polypeptide binding]; other site 476213009668 RodZ interaction site [polypeptide binding]; other site 476213009669 regulatory protein CsrD; Provisional; Region: PRK11059 476213009670 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 476213009671 metal binding site [ion binding]; metal-binding site 476213009672 nucleotidyl binding site; other site 476213009673 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 476213009674 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 476213009675 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 476213009676 NADP binding site [chemical binding]; other site 476213009677 dimer interface [polypeptide binding]; other site 476213009678 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 476213009679 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 476213009680 Moco binding site; other site 476213009681 metal coordination site [ion binding]; other site 476213009682 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 476213009683 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 476213009684 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 476213009685 carboxyltransferase (CT) interaction site; other site 476213009686 biotinylation site [posttranslational modification]; other site 476213009687 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 476213009688 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 476213009689 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 476213009690 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 476213009691 hypothetical protein; Provisional; Region: PRK10633 476213009692 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 476213009693 Na binding site [ion binding]; other site 476213009694 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 476213009695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 476213009696 S-adenosylmethionine binding site [chemical binding]; other site 476213009697 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 476213009698 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 476213009699 FMN binding site [chemical binding]; other site 476213009700 active site 476213009701 catalytic residues [active] 476213009702 substrate binding site [chemical binding]; other site 476213009703 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 476213009704 putative methyltransferase; Provisional; Region: PRK11524 476213009705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 476213009706 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 476213009707 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 476213009708 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 476213009709 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 476213009710 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 476213009711 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 476213009712 HlyD family secretion protein; Region: HlyD_3; pfam13437 476213009713 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 476213009714 MMPL family; Region: MMPL; cl14618 476213009715 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 476213009716 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 476213009717 trimer interface [polypeptide binding]; other site 476213009718 putative metal binding site [ion binding]; other site 476213009719 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 476213009720 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 476213009721 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 476213009722 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 476213009723 shikimate binding site; other site 476213009724 NAD(P) binding site [chemical binding]; other site 476213009725 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 476213009726 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 476213009727 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 476213009728 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 476213009729 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 476213009730 hypothetical protein; Validated; Region: PRK03430 476213009731 hypothetical protein; Provisional; Region: PRK10736 476213009732 DNA protecting protein DprA; Region: dprA; TIGR00732 476213009733 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 476213009734 active site 476213009735 catalytic residues [active] 476213009736 metal binding site [ion binding]; metal-binding site 476213009737 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 476213009738 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 476213009739 putative active site [active] 476213009740 substrate binding site [chemical binding]; other site 476213009741 putative cosubstrate binding site; other site 476213009742 catalytic site [active] 476213009743 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 476213009744 substrate binding site [chemical binding]; other site 476213009745 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 476213009746 putative RNA binding site [nucleotide binding]; other site 476213009747 16S rRNA methyltransferase B; Provisional; Region: PRK10901 476213009748 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 476213009749 S-adenosylmethionine binding site [chemical binding]; other site 476213009750 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 476213009751 TrkA-N domain; Region: TrkA_N; pfam02254 476213009752 TrkA-C domain; Region: TrkA_C; pfam02080 476213009753 TrkA-N domain; Region: TrkA_N; pfam02254 476213009754 TrkA-C domain; Region: TrkA_C; pfam02080 476213009755 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 476213009756 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 476213009757 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 476213009758 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 476213009759 DNA binding residues [nucleotide binding] 476213009760 dimer interface [polypeptide binding]; other site 476213009761 metal binding site [ion binding]; metal-binding site 476213009762 hypothetical protein; Provisional; Region: PRK10203 476213009763 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 476213009764 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 476213009765 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 476213009766 alphaNTD homodimer interface [polypeptide binding]; other site 476213009767 alphaNTD - beta interaction site [polypeptide binding]; other site 476213009768 alphaNTD - beta' interaction site [polypeptide binding]; other site 476213009769 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 476213009770 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 476213009771 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 476213009772 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 476213009773 RNA binding surface [nucleotide binding]; other site 476213009774 30S ribosomal protein S11; Validated; Region: PRK05309 476213009775 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 476213009776 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 476213009777 SecY translocase; Region: SecY; pfam00344 476213009778 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 476213009779 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 476213009780 23S rRNA binding site [nucleotide binding]; other site 476213009781 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 476213009782 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 476213009783 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 476213009784 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 476213009785 23S rRNA interface [nucleotide binding]; other site 476213009786 5S rRNA interface [nucleotide binding]; other site 476213009787 L27 interface [polypeptide binding]; other site 476213009788 L5 interface [polypeptide binding]; other site 476213009789 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 476213009790 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 476213009791 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 476213009792 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 476213009793 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 476213009794 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 476213009795 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 476213009796 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 476213009797 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 476213009798 RNA binding site [nucleotide binding]; other site 476213009799 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 476213009800 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 476213009801 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 476213009802 23S rRNA interface [nucleotide binding]; other site 476213009803 putative translocon interaction site; other site 476213009804 signal recognition particle (SRP54) interaction site; other site 476213009805 L23 interface [polypeptide binding]; other site 476213009806 trigger factor interaction site; other site 476213009807 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 476213009808 23S rRNA interface [nucleotide binding]; other site 476213009809 5S rRNA interface [nucleotide binding]; other site 476213009810 putative antibiotic binding site [chemical binding]; other site 476213009811 L25 interface [polypeptide binding]; other site 476213009812 L27 interface [polypeptide binding]; other site 476213009813 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 476213009814 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 476213009815 G-X-X-G motif; other site 476213009816 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 476213009817 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 476213009818 protein-rRNA interface [nucleotide binding]; other site 476213009819 putative translocon binding site; other site 476213009820 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 476213009821 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 476213009822 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 476213009823 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 476213009824 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 476213009825 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 476213009826 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 476213009827 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 476213009828 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 476213009829 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 476213009830 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 476213009831 Ferritin-like domain; Region: Ferritin; pfam00210 476213009832 heme binding site [chemical binding]; other site 476213009833 ferroxidase pore; other site 476213009834 ferroxidase diiron center [ion binding]; other site 476213009835 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 476213009836 elongation factor Tu; Reviewed; Region: PRK00049 476213009837 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 476213009838 G1 box; other site 476213009839 GEF interaction site [polypeptide binding]; other site 476213009840 GTP/Mg2+ binding site [chemical binding]; other site 476213009841 Switch I region; other site 476213009842 G2 box; other site 476213009843 G3 box; other site 476213009844 Switch II region; other site 476213009845 G4 box; other site 476213009846 G5 box; other site 476213009847 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 476213009848 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 476213009849 Antibiotic Binding Site [chemical binding]; other site 476213009850 elongation factor G; Reviewed; Region: PRK00007 476213009851 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 476213009852 G1 box; other site 476213009853 putative GEF interaction site [polypeptide binding]; other site 476213009854 GTP/Mg2+ binding site [chemical binding]; other site 476213009855 Switch I region; other site 476213009856 G2 box; other site 476213009857 G3 box; other site 476213009858 Switch II region; other site 476213009859 G4 box; other site 476213009860 G5 box; other site 476213009861 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 476213009862 Elongation Factor G, domain II; Region: EFG_II; pfam14492 476213009863 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 476213009864 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 476213009865 30S ribosomal protein S7; Validated; Region: PRK05302 476213009866 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 476213009867 S17 interaction site [polypeptide binding]; other site 476213009868 S8 interaction site; other site 476213009869 16S rRNA interaction site [nucleotide binding]; other site 476213009870 streptomycin interaction site [chemical binding]; other site 476213009871 23S rRNA interaction site [nucleotide binding]; other site 476213009872 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 476213009873 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 476213009874 sulfur relay protein TusC; Validated; Region: PRK00211 476213009875 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 476213009876 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 476213009877 YheO-like PAS domain; Region: PAS_6; pfam08348 476213009878 HTH domain; Region: HTH_22; pfam13309 476213009879 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 476213009880 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 476213009881 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 476213009882 phi X174 lysis protein; Provisional; Region: PRK02793 476213009883 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737 476213009884 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 476213009885 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 476213009886 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 476213009887 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 476213009888 TrkA-N domain; Region: TrkA_N; pfam02254 476213009889 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 476213009890 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 476213009891 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 476213009892 ABC transporter; Region: ABC_tran_2; pfam12848 476213009893 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 476213009894 Transcriptional regulator [Transcription]; Region: LysR; COG0583 476213009895 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213009896 putative monooxygenase; Provisional; Region: PRK11118 476213009897 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 476213009898 putative hydrolase; Provisional; Region: PRK10985 476213009899 hypothetical protein; Provisional; Region: PRK04966 476213009900 hypothetical protein; Provisional; Region: PRK10738 476213009901 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 476213009902 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 476213009903 ligand binding site [chemical binding]; other site 476213009904 flexible hinge region; other site 476213009905 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 476213009906 putative switch regulator; other site 476213009907 non-specific DNA interactions [nucleotide binding]; other site 476213009908 DNA binding site [nucleotide binding] 476213009909 sequence specific DNA binding site [nucleotide binding]; other site 476213009910 putative cAMP binding site [chemical binding]; other site 476213009911 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 476213009912 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 476213009913 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 476213009914 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 476213009915 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 476213009916 inhibitor-cofactor binding pocket; inhibition site 476213009917 pyridoxal 5'-phosphate binding site [chemical binding]; other site 476213009918 catalytic residue [active] 476213009919 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 476213009920 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 476213009921 glutamine binding [chemical binding]; other site 476213009922 catalytic triad [active] 476213009923 cell filamentation protein Fic; Provisional; Region: PRK10347 476213009924 hypothetical protein; Provisional; Region: PRK10204 476213009925 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 476213009926 substrate binding site [chemical binding]; other site 476213009927 putative transporter; Provisional; Region: PRK03699 476213009928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213009929 putative substrate translocation pore; other site 476213009930 nitrite reductase subunit NirD; Provisional; Region: PRK14989 476213009931 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 476213009932 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 476213009933 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 476213009934 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 476213009935 nitrite transporter NirC; Provisional; Region: PRK11562 476213009936 siroheme synthase; Provisional; Region: cysG; PRK10637 476213009937 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 476213009938 Sirohaem biosynthesis protein central; Region: Sirohm_synth_M; pfam14824 476213009939 Sirohaem synthase dimerization region; Region: CysG_dimeriser; pfam10414 476213009940 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 476213009941 active site 476213009942 SAM binding site [chemical binding]; other site 476213009943 homodimer interface [polypeptide binding]; other site 476213009944 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; cl19417 476213009945 hypothetical protein; Provisional; Region: PRK09946 476213009946 Autotransporter beta-domain; Region: Autotransporter; pfam03797 476213009947 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 476213009948 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 476213009949 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 476213009950 active site 476213009951 HIGH motif; other site 476213009952 dimer interface [polypeptide binding]; other site 476213009953 KMSKS motif; other site 476213009954 phosphoglycolate phosphatase; Provisional; Region: PRK13222 476213009955 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 476213009956 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 476213009957 motif II; other site 476213009958 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 476213009959 substrate binding site [chemical binding]; other site 476213009960 hexamer interface [polypeptide binding]; other site 476213009961 metal binding site [ion binding]; metal-binding site 476213009962 DNA adenine methylase; Provisional; Region: PRK10904 476213009963 cell division protein DamX; Validated; Region: PRK10905 476213009964 Sporulation related domain; Region: SPOR; pfam05036 476213009965 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 476213009966 active site 476213009967 dimer interface [polypeptide binding]; other site 476213009968 metal binding site [ion binding]; metal-binding site 476213009969 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 476213009970 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 476213009971 ADP binding site [chemical binding]; other site 476213009972 magnesium binding site [ion binding]; other site 476213009973 putative shikimate binding site; other site 476213009974 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 476213009975 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 476213009976 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 476213009977 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 476213009978 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 476213009979 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 476213009980 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 476213009981 Transglycosylase; Region: Transgly; pfam00912 476213009982 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 476213009983 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 476213009984 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 476213009985 ADP-ribose binding site [chemical binding]; other site 476213009986 dimer interface [polypeptide binding]; other site 476213009987 active site 476213009988 nudix motif; other site 476213009989 metal binding site [ion binding]; metal-binding site 476213009990 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 476213009991 GMP/IMP nucleotidase; Provisional; Region: PRK14988 476213009992 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 476213009993 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 476213009994 motif II; other site 476213009995 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 476213009996 RNA binding surface [nucleotide binding]; other site 476213009997 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 476213009998 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 476213009999 dimerization interface [polypeptide binding]; other site 476213010000 domain crossover interface; other site 476213010001 redox-dependent activation switch; other site 476213010002 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 476213010003 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 476213010004 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 476213010005 active site 476213010006 substrate-binding site [chemical binding]; other site 476213010007 metal-binding site [ion binding] 476213010008 ATP binding site [chemical binding]; other site 476213010009 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 476213010010 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 476213010011 dimerization interface [polypeptide binding]; other site 476213010012 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 476213010013 dimer interface [polypeptide binding]; other site 476213010014 phosphorylation site [posttranslational modification] 476213010015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 476213010016 ATP binding site [chemical binding]; other site 476213010017 Mg2+ binding site [ion binding]; other site 476213010018 G-X-G motif; other site 476213010019 osmolarity response regulator; Provisional; Region: ompR; PRK09468 476213010020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 476213010021 active site 476213010022 phosphorylation site [posttranslational modification] 476213010023 intermolecular recognition site; other site 476213010024 dimerization interface [polypeptide binding]; other site 476213010025 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 476213010026 DNA binding site [nucleotide binding] 476213010027 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 476213010028 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 476213010029 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 476213010030 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 476213010031 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 476213010032 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 476213010033 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 476213010034 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 476213010035 RNA binding site [nucleotide binding]; other site 476213010036 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 476213010037 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 476213010038 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 476213010039 G1 box; other site 476213010040 GTP/Mg2+ binding site [chemical binding]; other site 476213010041 Switch I region; other site 476213010042 G2 box; other site 476213010043 G3 box; other site 476213010044 Switch II region; other site 476213010045 G4 box; other site 476213010046 G5 box; other site 476213010047 Nucleoside recognition; Region: Gate; pfam07670 476213010048 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 476213010049 Nucleoside recognition; Region: Gate; pfam07670 476213010050 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 476213010051 hypothetical protein; Provisional; Region: PRK09956 476213010052 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 476213010053 carboxylesterase BioH; Provisional; Region: PRK10349 476213010054 Putative lysophospholipase; Region: Hydrolase_4; cl19140 476213010055 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 476213010056 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 476213010057 active site 476213010058 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 476213010059 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 476213010060 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 476213010061 high-affinity gluconate transporter; Provisional; Region: PRK14984 476213010062 GntP family permease; Region: GntP_permease; pfam02447 476213010063 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 476213010064 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 476213010065 maltodextrin phosphorylase; Provisional; Region: PRK14985 476213010066 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 476213010067 homodimer interface [polypeptide binding]; other site 476213010068 active site pocket [active] 476213010069 transcriptional regulator MalT; Provisional; Region: PRK04841 476213010070 AAA ATPase domain; Region: AAA_16; pfam13191 476213010071 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 476213010072 DNA binding residues [nucleotide binding] 476213010073 dimerization interface [polypeptide binding]; other site 476213010074 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 476213010075 starch-binding site 1 [chemical binding]; other site 476213010076 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 476213010077 RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874 476213010078 putative active site [active] 476213010079 adenylation catalytic residue [active] 476213010080 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 476213010081 tRNA-splicing ligase RtcB; Region: RtcB; pfam01139 476213010082 TROVE domain; Region: TROVE; pfam05731 476213010083 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 476213010084 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 476213010085 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 476213010086 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 476213010087 intramembrane serine protease GlpG; Provisional; Region: PRK10907 476213010088 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 476213010089 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 476213010090 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 476213010091 active site residue [active] 476213010092 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 476213010093 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 476213010094 hypothetical protein; Provisional; Region: PRK09781 476213010095 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 476213010096 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 476213010097 dimer interface [polypeptide binding]; other site 476213010098 active site 476213010099 metal binding site [ion binding]; metal-binding site 476213010100 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213010101 D-galactonate transporter; Region: 2A0114; TIGR00893 476213010102 putative substrate translocation pore; other site 476213010103 Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism / Carbohydrate transport and metabolism]; Region: IlvD; COG0129 476213010104 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 476213010105 inhibitor site; inhibition site 476213010106 active site 476213010107 dimer interface [polypeptide binding]; other site 476213010108 catalytic residue [active] 476213010109 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 476213010110 Transcriptional regulator [Transcription]; Region: IclR; COG1414 476213010111 Bacterial transcriptional regulator; Region: IclR; pfam01614 476213010112 glycogen phosphorylase; Provisional; Region: PRK14986 476213010113 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 476213010114 homodimer interface [polypeptide binding]; other site 476213010115 active site pocket [active] 476213010116 glycogen synthase; Provisional; Region: glgA; PRK00654 476213010117 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 476213010118 ADP-binding pocket [chemical binding]; other site 476213010119 homodimer interface [polypeptide binding]; other site 476213010120 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 476213010121 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 476213010122 ligand binding site; other site 476213010123 oligomer interface; other site 476213010124 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 476213010125 dimer interface [polypeptide binding]; other site 476213010126 N-terminal domain interface [polypeptide binding]; other site 476213010127 sulfate 1 binding site; other site 476213010128 glycogen debranching enzyme; Provisional; Region: PRK03705 476213010129 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 476213010130 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 476213010131 active site 476213010132 catalytic site [active] 476213010133 glycogen branching enzyme; Provisional; Region: PRK05402 476213010134 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 476213010135 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 476213010136 active site 476213010137 catalytic site [active] 476213010138 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 476213010139 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 476213010140 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 476213010141 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 476213010142 low affinity gluconate transporter; Provisional; Region: PRK10472 476213010143 GntP family permease; Region: GntP_permease; pfam02447 476213010144 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 476213010145 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 476213010146 ATP-binding site [chemical binding]; other site 476213010147 Gluconate-6-phosphate binding site [chemical binding]; other site 476213010148 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 476213010149 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 476213010150 DNA binding site [nucleotide binding] 476213010151 domain linker motif; other site 476213010152 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 476213010153 putative ligand binding site [chemical binding]; other site 476213010154 putative dimerization interface [polypeptide binding]; other site 476213010155 Pirin-related protein [General function prediction only]; Region: COG1741 476213010156 Pirin; Region: Pirin; pfam02678 476213010157 putative oxidoreductase; Provisional; Region: PRK10206 476213010158 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 476213010159 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 476213010160 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 476213010161 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 476213010162 Coenzyme A binding pocket [chemical binding]; other site 476213010163 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 476213010164 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 476213010165 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 476213010166 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 476213010167 substrate binding site [chemical binding]; other site 476213010168 dimer interface [polypeptide binding]; other site 476213010169 ATP binding site [chemical binding]; other site 476213010170 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 476213010171 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 476213010172 Protein of unknown function, DUF606; Region: DUF606; pfam04657 476213010173 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 476213010174 active site 476213010175 substrate binding pocket [chemical binding]; other site 476213010176 homodimer interaction site [polypeptide binding]; other site 476213010177 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 476213010178 hypothetical protein; Provisional; Region: PRK10350 476213010179 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 476213010180 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 476213010181 putative active site [active] 476213010182 catalytic site [active] 476213010183 putative metal binding site [ion binding]; other site 476213010184 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 476213010185 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 476213010186 Walker A/P-loop; other site 476213010187 ATP binding site [chemical binding]; other site 476213010188 Q-loop/lid; other site 476213010189 ABC transporter signature motif; other site 476213010190 Walker B; other site 476213010191 D-loop; other site 476213010192 H-loop/switch region; other site 476213010193 TOBE domain; Region: TOBE_2; pfam08402 476213010194 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 476213010195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213010196 dimer interface [polypeptide binding]; other site 476213010197 conserved gate region; other site 476213010198 ABC-ATPase subunit interface; other site 476213010199 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 476213010200 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213010201 dimer interface [polypeptide binding]; other site 476213010202 conserved gate region; other site 476213010203 putative PBP binding loops; other site 476213010204 ABC-ATPase subunit interface; other site 476213010205 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 476213010206 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 476213010207 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 476213010208 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 476213010209 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 476213010210 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 476213010211 Walker A/P-loop; other site 476213010212 ATP binding site [chemical binding]; other site 476213010213 Q-loop/lid; other site 476213010214 ABC transporter signature motif; other site 476213010215 Walker B; other site 476213010216 D-loop; other site 476213010217 H-loop/switch region; other site 476213010218 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 476213010219 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 476213010220 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 476213010221 TM-ABC transporter signature motif; other site 476213010222 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 476213010223 TM-ABC transporter signature motif; other site 476213010224 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 476213010225 dimerization interface [polypeptide binding]; other site 476213010226 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 476213010227 ligand binding site [chemical binding]; other site 476213010228 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 476213010229 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 476213010230 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 476213010231 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 476213010232 dimerization interface [polypeptide binding]; other site 476213010233 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 476213010234 ligand binding site [chemical binding]; other site 476213010235 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 476213010236 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 476213010237 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 476213010238 DNA binding residues [nucleotide binding] 476213010239 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 476213010240 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 476213010241 cell division protein FtsE; Provisional; Region: PRK10908 476213010242 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 476213010243 Walker A/P-loop; other site 476213010244 ATP binding site [chemical binding]; other site 476213010245 Q-loop/lid; other site 476213010246 ABC transporter signature motif; other site 476213010247 Walker B; other site 476213010248 D-loop; other site 476213010249 H-loop/switch region; other site 476213010250 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 476213010251 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 476213010252 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 476213010253 P loop; other site 476213010254 GTP binding site [chemical binding]; other site 476213010255 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 476213010256 S-adenosylmethionine binding site [chemical binding]; other site 476213010257 hypothetical protein; Provisional; Region: PRK10910 476213010258 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 476213010259 Predicted membrane protein [Function unknown]; Region: COG3714 476213010260 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 476213010261 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 476213010262 metal-binding site [ion binding] 476213010263 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 476213010264 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 476213010265 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 476213010266 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 476213010267 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 476213010268 dimer interface [polypeptide binding]; other site 476213010269 ligand binding site [chemical binding]; other site 476213010270 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 476213010271 dimerization interface [polypeptide binding]; other site 476213010272 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 476213010273 dimer interface [polypeptide binding]; other site 476213010274 putative CheW interface [polypeptide binding]; other site 476213010275 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 476213010276 CPxP motif; other site 476213010277 hypothetical protein; Provisional; Region: PRK11212 476213010278 hypothetical protein; Provisional; Region: PRK11615 476213010279 major facilitator superfamily transporter; Provisional; Region: PRK05122 476213010280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213010281 putative substrate translocation pore; other site 476213010282 Domain of unknown function DUF20; Region: UPF0118; cl00465 476213010283 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 476213010284 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 476213010285 nickel responsive regulator; Provisional; Region: PRK02967 476213010286 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 476213010287 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 476213010288 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 476213010289 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 476213010290 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 476213010291 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 476213010292 Walker A/P-loop; other site 476213010293 ATP binding site [chemical binding]; other site 476213010294 Q-loop/lid; other site 476213010295 ABC transporter signature motif; other site 476213010296 Walker B; other site 476213010297 D-loop; other site 476213010298 H-loop/switch region; other site 476213010299 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 476213010300 Walker A/P-loop; other site 476213010301 ATP binding site [chemical binding]; other site 476213010302 Q-loop/lid; other site 476213010303 ABC transporter signature motif; other site 476213010304 Walker B; other site 476213010305 D-loop; other site 476213010306 H-loop/switch region; other site 476213010307 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 476213010308 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 476213010309 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 476213010310 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 476213010311 HlyD family secretion protein; Region: HlyD_3; pfam13437 476213010312 Predicted flavoproteins [General function prediction only]; Region: COG2081 476213010313 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 476213010314 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 476213010315 universal stress protein UspB; Provisional; Region: PRK04960 476213010316 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 476213010317 Ligand Binding Site [chemical binding]; other site 476213010318 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 476213010319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213010320 putative substrate translocation pore; other site 476213010321 putative methyltransferase; Provisional; Region: PRK10742 476213010322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 476213010323 S-adenosylmethionine binding site [chemical binding]; other site 476213010324 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 476213010325 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 476213010326 active site 476213010327 Zn binding site [ion binding]; other site 476213010328 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 476213010329 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 476213010330 active site 476213010331 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 476213010332 glutathione reductase; Validated; Region: PRK06116 476213010333 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 476213010334 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 476213010335 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 476213010336 polyol permease family; Region: 2A0118; TIGR00897 476213010337 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213010338 putative substrate translocation pore; other site 476213010339 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 476213010340 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 476213010341 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 476213010342 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 476213010343 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 476213010344 putative active site [active] 476213010345 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 476213010346 substrate binding site [chemical binding]; other site 476213010347 dimer interface [polypeptide binding]; other site 476213010348 ATP binding site [chemical binding]; other site 476213010349 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 476213010350 active site 476213010351 homotetramer interface [polypeptide binding]; other site 476213010352 homodimer interface [polypeptide binding]; other site 476213010353 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 476213010354 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 476213010355 substrate binding site [chemical binding]; other site 476213010356 ATP binding site [chemical binding]; other site 476213010357 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 476213010358 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 476213010359 putative active site [active] 476213010360 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 476213010361 dimer interface [polypeptide binding]; other site 476213010362 active site 476213010363 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 476213010364 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 476213010365 DNA-binding site [nucleotide binding]; DNA binding site 476213010366 UTRA domain; Region: UTRA; pfam07702 476213010367 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 476213010368 trehalase; Provisional; Region: treF; PRK13270 476213010369 Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772 476213010370 catalytic residue [active] 476213010371 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 476213010372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078 476213010373 active site 476213010374 phosphorylation site [posttranslational modification] 476213010375 dimerization interface [polypeptide binding]; other site 476213010376 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 476213010377 DNA binding residues [nucleotide binding] 476213010378 dimerization interface [polypeptide binding]; other site 476213010379 inner membrane protein YhjD; Region: TIGR00766 476213010380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213010381 metabolite-proton symporter; Region: 2A0106; TIGR00883 476213010382 putative substrate translocation pore; other site 476213010383 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 476213010384 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 476213010385 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 476213010386 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 476213010387 substrate binding site [chemical binding]; other site 476213010388 ATP binding site [chemical binding]; other site 476213010389 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 476213010390 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 476213010391 putative diguanylate cyclase; Provisional; Region: PRK13561 476213010392 HAMP domain; Region: HAMP; pfam00672 476213010393 diguanylate cyclase; Region: GGDEF; smart00267 476213010394 metal binding site [ion binding]; metal-binding site 476213010395 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 476213010396 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 476213010397 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 476213010398 TPR motif; other site 476213010399 binding surface 476213010400 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 476213010401 TPR motif; other site 476213010402 binding surface 476213010403 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 476213010404 binding surface 476213010405 TPR motif; other site 476213010406 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 476213010407 endo-1,4-D-glucanase; Provisional; Region: PRK11097 476213010408 cellulose synthase regulator protein; Provisional; Region: PRK11114 476213010409 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 476213010410 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 476213010411 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 476213010412 DXD motif; other site 476213010413 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 476213010414 PilZ domain; Region: PilZ; pfam07238 476213010415 cell division protein; Provisional; Region: PRK10037 476213010416 YhjQ protein; Region: YhjQ; pfam06564 476213010417 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 476213010418 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 476213010419 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 476213010420 cellulose synthase operon protein YhjU; Region: cellulose_yhjU; TIGR03368 476213010421 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 476213010422 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 476213010423 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 476213010424 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 476213010425 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 476213010426 Walker A/P-loop; other site 476213010427 ATP binding site [chemical binding]; other site 476213010428 Q-loop/lid; other site 476213010429 ABC transporter signature motif; other site 476213010430 Walker B; other site 476213010431 D-loop; other site 476213010432 H-loop/switch region; other site 476213010433 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 476213010434 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 476213010435 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 476213010436 Walker A/P-loop; other site 476213010437 ATP binding site [chemical binding]; other site 476213010438 Q-loop/lid; other site 476213010439 ABC transporter signature motif; other site 476213010440 Walker B; other site 476213010441 D-loop; other site 476213010442 H-loop/switch region; other site 476213010443 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 476213010444 dipeptide transporter; Provisional; Region: PRK10913 476213010445 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 476213010446 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213010447 dimer interface [polypeptide binding]; other site 476213010448 conserved gate region; other site 476213010449 putative PBP binding loops; other site 476213010450 ABC-ATPase subunit interface; other site 476213010451 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 476213010452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213010453 dimer interface [polypeptide binding]; other site 476213010454 conserved gate region; other site 476213010455 putative PBP binding loops; other site 476213010456 ABC-ATPase subunit interface; other site 476213010457 antimicrobial peptide ABC transporter periplasmic binding protein SapA; Provisional; Region: PRK15109 476213010458 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 476213010459 peptide binding site [polypeptide binding]; other site 476213010460 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 476213010461 Sulfate transporter family; Region: Sulfate_transp; cl19250 476213010462 Arylsulfotransferase (ASST); Region: Arylsulfotrans; cl19972 476213010463 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 476213010464 Transcriptional regulators [Transcription]; Region: PurR; COG1609 476213010465 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 476213010466 DNA binding site [nucleotide binding] 476213010467 domain linker motif; other site 476213010468 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_8; cd06287 476213010469 putative dimerization interface [polypeptide binding]; other site 476213010470 putative ligand binding site [chemical binding]; other site 476213010471 phosphoethanolamine transferase; Provisional; Region: PRK11560 476213010472 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 476213010473 Sulfatase; Region: Sulfatase; pfam00884 476213010474 long polar fimbrial protein LpfE; Provisional; Region: PRK15205 476213010475 long polar fimbrial protein LpfD; Provisional; Region: PRK15206 476213010476 long polar fimbrial outer membrane usher protein LpfC; Provisional; Region: PRK15207 476213010477 PapC N-terminal domain; Region: PapC_N; pfam13954 476213010478 Outer membrane usher protein; Region: Usher; pfam00577 476213010479 PapC C-terminal domain; Region: PapC_C; pfam13953 476213010480 long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208 476213010481 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 476213010482 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 476213010483 long polar fimbrial protein LpfA; Provisional; Region: PRK15209 476213010484 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 476213010485 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 476213010486 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 476213010487 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 476213010488 Coenzyme A binding pocket [chemical binding]; other site 476213010489 putative outer membrane lipoprotein; Provisional; Region: PRK10510 476213010490 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 476213010491 ligand binding site [chemical binding]; other site 476213010492 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 476213010493 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 476213010494 dimerization interface [polypeptide binding]; other site 476213010495 ligand binding site [chemical binding]; other site 476213010496 NADP binding site [chemical binding]; other site 476213010497 catalytic site [active] 476213010498 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 476213010499 Predicted transcriptional regulator [Transcription]; Region: COG2944 476213010500 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 476213010501 salt bridge; other site 476213010502 non-specific DNA binding site [nucleotide binding]; other site 476213010503 sequence-specific DNA binding site [nucleotide binding]; other site 476213010504 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 476213010505 DNA-binding site [nucleotide binding]; DNA binding site 476213010506 RNA-binding motif; other site 476213010507 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 476213010508 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 476213010509 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 476213010510 Coenzyme A binding pocket [chemical binding]; other site 476213010511 Integrase core domain; Region: rve; pfam00665 476213010512 Integrase core domain; Region: rve_2; pfam13333 476213010513 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 476213010514 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 476213010515 DALR anticodon binding domain; Region: DALR_1; pfam05746 476213010516 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 476213010517 dimer interface [polypeptide binding]; other site 476213010518 motif 1; other site 476213010519 active site 476213010520 motif 2; other site 476213010521 motif 3; other site 476213010522 YsaB-like lipoprotein; Region: YsaB; pfam13983 476213010523 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 476213010524 Predicted membrane protein [Function unknown]; Region: COG4682 476213010525 yiaA/B two helix domain; Region: YiaAB; pfam05360 476213010526 yiaA/B two helix domain; Region: YiaAB; cl01759 476213010527 xylulokinase; Provisional; Region: PRK15027 476213010528 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 476213010529 N- and C-terminal domain interface [polypeptide binding]; other site 476213010530 active site 476213010531 MgATP binding site [chemical binding]; other site 476213010532 catalytic site [active] 476213010533 metal binding site [ion binding]; metal-binding site 476213010534 xylulose binding site [chemical binding]; other site 476213010535 homodimer interface [polypeptide binding]; other site 476213010536 xylose isomerase; Provisional; Region: PRK05474 476213010537 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 476213010538 putative dimerization interface [polypeptide binding]; other site 476213010539 Transcriptional regulators [Transcription]; Region: PurR; COG1609 476213010540 putative ligand binding site [chemical binding]; other site 476213010541 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213010542 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 476213010543 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213010544 hypothetical protein; Provisional; Region: PRK10356 476213010545 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 476213010546 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 476213010547 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 476213010548 pyridoxal 5'-phosphate binding site [chemical binding]; other site 476213010549 homodimer interface [polypeptide binding]; other site 476213010550 catalytic residue [active] 476213010551 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 476213010552 Transcriptional regulator [Transcription]; Region: IclR; COG1414 476213010553 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 476213010554 Bacterial transcriptional regulator; Region: IclR; pfam01614 476213010555 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 476213010556 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 476213010557 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 476213010558 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 476213010559 DctM-like transporters; Region: DctM; pfam06808 476213010560 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 476213010561 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 476213010562 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 476213010563 putative N- and C-terminal domain interface [polypeptide binding]; other site 476213010564 putative active site [active] 476213010565 MgATP binding site [chemical binding]; other site 476213010566 catalytic site [active] 476213010567 metal binding site [ion binding]; metal-binding site 476213010568 putative xylulose binding site [chemical binding]; other site 476213010569 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 476213010570 active site 476213010571 dimer interface [polypeptide binding]; other site 476213010572 magnesium binding site [ion binding]; other site 476213010573 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 476213010574 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 476213010575 AP (apurinic/apyrimidinic) site pocket; other site 476213010576 DNA interaction; other site 476213010577 Metal-binding active site; metal-binding site 476213010578 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 476213010579 intersubunit interface [polypeptide binding]; other site 476213010580 active site 476213010581 Zn2+ binding site [ion binding]; other site 476213010582 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 476213010583 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 476213010584 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213010585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 476213010586 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like; Region: ALDH_ACDHII_AcoD-like; cd07559 476213010587 NAD(P) binding site [chemical binding]; other site 476213010588 catalytic residues [active] 476213010589 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 476213010590 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 476213010591 nucleotide binding site [chemical binding]; other site 476213010592 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 476213010593 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 476213010594 G1 box; other site 476213010595 putative GEF interaction site [polypeptide binding]; other site 476213010596 GTP/Mg2+ binding site [chemical binding]; other site 476213010597 Switch I region; other site 476213010598 G2 box; other site 476213010599 G3 box; other site 476213010600 Switch II region; other site 476213010601 G4 box; other site 476213010602 G5 box; other site 476213010603 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 476213010604 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 476213010605 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 476213010606 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 476213010607 selenocysteine synthase; Provisional; Region: PRK04311 476213010608 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 476213010609 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 476213010610 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 476213010611 catalytic residue [active] 476213010612 putative glutathione S-transferase; Provisional; Region: PRK10357 476213010613 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 476213010614 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 476213010615 dimer interface [polypeptide binding]; other site 476213010616 N-terminal domain interface [polypeptide binding]; other site 476213010617 putative substrate binding pocket (H-site) [chemical binding]; other site 476213010618 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 476213010619 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 476213010620 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 476213010621 active site 476213010622 P-loop; other site 476213010623 phosphorylation site [posttranslational modification] 476213010624 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 476213010625 active site 476213010626 phosphorylation site [posttranslational modification] 476213010627 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 476213010628 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 476213010629 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 476213010630 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 476213010631 hypothetical protein; Provisional; Region: PRK11020 476213010632 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 476213010633 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 476213010634 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 476213010635 trimer interface [polypeptide binding]; other site 476213010636 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 476213010637 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 476213010638 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 476213010639 Coiled stalk of trimeric autotransporter adhesin; Region: YadA_stalk; pfam05662 476213010640 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 476213010641 trimer interface [polypeptide binding]; other site 476213010642 Coiled stalk of trimeric autotransporter adhesin; Region: YadA_stalk; pfam05662 476213010643 YadA-like C-terminal region; Region: YadA_anchor; pfam03895 476213010644 L-lactate permease; Provisional; Region: PRK10420 476213010645 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 476213010646 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 476213010647 DNA-binding site [nucleotide binding]; DNA binding site 476213010648 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 476213010649 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 476213010650 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 476213010651 active site 476213010652 substrate binding site [chemical binding]; other site 476213010653 FMN binding site [chemical binding]; other site 476213010654 putative catalytic residues [active] 476213010655 putative rRNA methylase; Provisional; Region: PRK10358 476213010656 Transcriptional regulators [Transcription]; Region: PurR; COG1609 476213010657 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 476213010658 DNA binding site [nucleotide binding] 476213010659 domain linker motif; other site 476213010660 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 476213010661 putative dimerization interface [polypeptide binding]; other site 476213010662 putative ligand binding site [chemical binding]; other site 476213010663 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213010664 D-galactonate transporter; Region: 2A0114; TIGR00893 476213010665 putative substrate translocation pore; other site 476213010666 serine acetyltransferase; Provisional; Region: cysE; PRK11132 476213010667 Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971 476213010668 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 476213010669 trimer interface [polypeptide binding]; other site 476213010670 active site 476213010671 substrate binding site [chemical binding]; other site 476213010672 CoA binding site [chemical binding]; other site 476213010673 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 476213010674 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 476213010675 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 476213010676 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 476213010677 SecA binding site; other site 476213010678 Preprotein binding site; other site 476213010679 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 476213010680 GSH binding site [chemical binding]; other site 476213010681 catalytic residues [active] 476213010682 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 476213010683 active site residue [active] 476213010684 phosphoglyceromutase; Provisional; Region: PRK05434 476213010685 AmiB activator; Provisional; Region: PRK11637 476213010686 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 476213010687 Peptidase family M23; Region: Peptidase_M23; pfam01551 476213010688 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 476213010689 NodB motif; other site 476213010690 putative active site [active] 476213010691 putative catalytic site [active] 476213010692 Zn binding site [ion binding]; other site 476213010693 putative glycosyl transferase; Provisional; Region: PRK10073 476213010694 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 476213010695 active site 476213010696 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 476213010697 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 476213010698 NAD(P) binding site [chemical binding]; other site 476213010699 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 476213010700 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 476213010701 substrate-cofactor binding pocket; other site 476213010702 pyridoxal 5'-phosphate binding site [chemical binding]; other site 476213010703 catalytic residue [active] 476213010704 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 476213010705 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 476213010706 NADP binding site [chemical binding]; other site 476213010707 homopentamer interface [polypeptide binding]; other site 476213010708 substrate binding site [chemical binding]; other site 476213010709 active site 476213010710 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 476213010711 putative active site [active] 476213010712 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 476213010713 putative active site [active] 476213010714 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 476213010715 O-antigen ligase RfaL; Provisional; Region: PRK15487 476213010716 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 476213010717 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 476213010718 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 476213010719 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10359 476213010720 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 476213010721 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 476213010722 Ligand binding site; other site 476213010723 metal-binding site 476213010724 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 476213010725 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 476213010726 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 476213010727 Ligand binding site; other site 476213010728 metal-binding site 476213010729 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 476213010730 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 476213010731 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 476213010732 putative ADP-binding pocket [chemical binding]; other site 476213010733 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 476213010734 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 476213010735 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 476213010736 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 476213010737 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 476213010738 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 476213010739 putative active site [active] 476213010740 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 476213010741 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 476213010742 Glycosyl transferases group 1; Region: Glycos_transf_1; cl19138 476213010743 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 476213010744 active site 476213010745 (T/H)XGH motif; other site 476213010746 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 476213010747 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 476213010748 DNA binding site [nucleotide binding] 476213010749 catalytic residue [active] 476213010750 H2TH interface [polypeptide binding]; other site 476213010751 putative catalytic residues [active] 476213010752 turnover-facilitating residue; other site 476213010753 intercalation triad [nucleotide binding]; other site 476213010754 8OG recognition residue [nucleotide binding]; other site 476213010755 putative reading head residues; other site 476213010756 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 476213010757 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 476213010758 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 476213010759 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 476213010760 hypothetical protein; Reviewed; Region: PRK00024 476213010761 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 476213010762 MPN+ (JAMM) motif; other site 476213010763 Zinc-binding site [ion binding]; other site 476213010764 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 476213010765 trimer interface [polypeptide binding]; other site 476213010766 active site 476213010767 division inhibitor protein; Provisional; Region: slmA; PRK09480 476213010768 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 476213010769 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 476213010770 active site 476213010771 ribonuclease PH; Reviewed; Region: rph; PRK00173 476213010772 Ribonuclease PH; Region: RNase_PH_bact; cd11362 476213010773 hexamer interface [polypeptide binding]; other site 476213010774 active site 476213010775 hypothetical protein; Provisional; Region: PRK11820 476213010776 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 476213010777 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 476213010778 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 476213010779 Predicted membrane protein [Function unknown]; Region: COG2860 476213010780 UPF0126 domain; Region: UPF0126; pfam03458 476213010781 UPF0126 domain; Region: UPF0126; pfam03458 476213010782 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 476213010783 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 476213010784 nucleotide binding pocket [chemical binding]; other site 476213010785 K-X-D-G motif; other site 476213010786 catalytic site [active] 476213010787 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 476213010788 Guanylate kinase; Region: Guanylate_kin; pfam00625 476213010789 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 476213010790 catalytic site [active] 476213010791 G-X2-G-X-G-K; other site 476213010792 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 476213010793 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 476213010794 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 476213010795 Zn2+ binding site [ion binding]; other site 476213010796 Mg2+ binding site [ion binding]; other site 476213010797 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 476213010798 synthetase active site [active] 476213010799 NTP binding site [chemical binding]; other site 476213010800 metal binding site [ion binding]; metal-binding site 476213010801 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 476213010802 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 476213010803 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 476213010804 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 476213010805 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 476213010806 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 476213010807 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 476213010808 generic binding surface II; other site 476213010809 ssDNA binding site; other site 476213010810 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 476213010811 ATP binding site [chemical binding]; other site 476213010812 putative Mg++ binding site [ion binding]; other site 476213010813 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 476213010814 nucleotide binding region [chemical binding]; other site 476213010815 ATP-binding site [chemical binding]; other site 476213010816 Sodium/glutamate symporter; Region: Glt_symporter; cl19414 476213010817 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 476213010818 Sulfate transporter family; Region: Sulfate_transp; cl19250 476213010819 AsmA family; Region: AsmA; pfam05170 476213010820 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 476213010821 putative transporter; Provisional; Region: PRK11462 476213010822 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 476213010823 Transposase; Region: HTH_Tnp_1; cl17663 476213010824 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 476213010825 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 476213010826 autotransport protein MisL; Provisional; Region: PRK15313 476213010827 tail sheath protein; Provisional; Region: 18; PHA02539 476213010828 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 476213010829 Autotransporter beta-domain; Region: Autotransporter; pfam03797 476213010830 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 476213010831 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 476213010832 DNA binding site [nucleotide binding] 476213010833 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 476213010834 catalytic triad [active] 476213010835 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 476213010836 magnesium-transporting ATPase; Provisional; Region: PRK15122 476213010837 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 476213010838 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 476213010839 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 476213010840 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 476213010841 active site 476213010842 motif I; other site 476213010843 motif II; other site 476213010844 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 476213010845 magnesium transport protein MgtC; Provisional; Region: PRK15385 476213010846 MgtC family; Region: MgtC; pfam02308 476213010847 EamA-like transporter family; Region: EamA; pfam00892 476213010848 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 476213010849 EamA-like transporter family; Region: EamA; pfam00892 476213010850 hypothetical protein; Provisional; Region: PRK09956 476213010851 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 476213010852 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 476213010853 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 476213010854 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 476213010855 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 476213010856 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 476213010857 active site 476213010858 phosphorylation site [posttranslational modification] 476213010859 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 476213010860 active pocket/dimerization site; other site 476213010861 active site 476213010862 phosphorylation site [posttranslational modification] 476213010863 Predicted transcriptional regulators [Transcription]; Region: ArsR; COG0640 476213010864 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 476213010865 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 476213010866 Walker A motif; other site 476213010867 ATP binding site [chemical binding]; other site 476213010868 Walker B motif; other site 476213010869 arginine finger; other site 476213010870 Transcriptional antiterminator [Transcription]; Region: COG3933 476213010871 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 476213010872 active site 476213010873 active pocket/dimerization site; other site 476213010874 phosphorylation site [posttranslational modification] 476213010875 PRD domain; Region: PRD; pfam00874 476213010876 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 476213010877 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 476213010878 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 476213010879 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213010880 putative substrate translocation pore; other site 476213010881 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737 476213010882 Predicted transcriptional regulator [Transcription]; Region: COG2944 476213010883 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 476213010884 non-specific DNA binding site [nucleotide binding]; other site 476213010885 salt bridge; other site 476213010886 sequence-specific DNA binding site [nucleotide binding]; other site 476213010887 GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440 476213010888 GIY-YIG motif/motif A; other site 476213010889 putative active site [active] 476213010890 putative metal binding site [ion binding]; other site 476213010891 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 476213010892 dimerization domain swap beta strand [polypeptide binding]; other site 476213010893 regulatory protein interface [polypeptide binding]; other site 476213010894 active site 476213010895 regulatory phosphorylation site [posttranslational modification]; other site 476213010896 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 476213010897 intersubunit interface [polypeptide binding]; other site 476213010898 active site 476213010899 zinc binding site [ion binding]; other site 476213010900 Na+ binding site [ion binding]; other site 476213010901 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 476213010902 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 476213010903 nucleotide binding site [chemical binding]; other site 476213010904 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 476213010905 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 476213010906 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 476213010907 active site 476213010908 phosphorylation site [posttranslational modification] 476213010909 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 476213010910 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 476213010911 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213010912 putative substrate translocation pore; other site 476213010913 regulatory protein UhpC; Provisional; Region: PRK11663 476213010914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213010915 putative substrate translocation pore; other site 476213010916 sensory histidine kinase UhpB; Provisional; Region: PRK11644 476213010917 MASE1; Region: MASE1; pfam05231 476213010918 Histidine kinase; Region: HisKA_3; pfam07730 476213010919 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 476213010920 ATP binding site [chemical binding]; other site 476213010921 Mg2+ binding site [ion binding]; other site 476213010922 G-X-G motif; other site 476213010923 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 476213010924 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 476213010925 active site 476213010926 phosphorylation site [posttranslational modification] 476213010927 intermolecular recognition site; other site 476213010928 dimerization interface [polypeptide binding]; other site 476213010929 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 476213010930 DNA binding residues [nucleotide binding] 476213010931 dimerization interface [polypeptide binding]; other site 476213010932 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 476213010933 active site 476213010934 catalytic residues [active] 476213010935 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 476213010936 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213010937 putative substrate translocation pore; other site 476213010938 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 476213010939 substrate binding site [chemical binding]; other site 476213010940 dimer interface [polypeptide binding]; other site 476213010941 ATP binding site [chemical binding]; other site 476213010942 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 476213010943 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 476213010944 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 476213010945 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 476213010946 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 476213010947 putative valine binding site [chemical binding]; other site 476213010948 dimer interface [polypeptide binding]; other site 476213010949 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 476213010950 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 476213010951 PYR/PP interface [polypeptide binding]; other site 476213010952 dimer interface [polypeptide binding]; other site 476213010953 TPP binding site [chemical binding]; other site 476213010954 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 476213010955 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 476213010956 TPP-binding site [chemical binding]; other site 476213010957 dimer interface [polypeptide binding]; other site 476213010958 ilvB operon leader peptide; Provisional; Region: PRK10214 476213010959 Toxin TisB, type I toxin-antitoxin system; Region: TisB_toxin; pfam13939 476213010960 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 476213010961 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 476213010962 EamA-like transporter family; Region: EamA; pfam00892 476213010963 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 476213010964 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213010965 putative substrate translocation pore; other site 476213010966 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 476213010967 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 476213010968 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213010969 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 476213010970 dimerization interface [polypeptide binding]; other site 476213010971 substrate binding pocket [chemical binding]; other site 476213010972 permease DsdX; Provisional; Region: PRK09921 476213010973 GntP family permease; Region: GntP_permease; pfam02447 476213010974 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 476213010975 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 476213010976 catalytic residue [active] 476213010977 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 476213010978 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 476213010979 Domain of unknown function (DUF202); Region: DUF202; pfam02656 476213010980 Predicted membrane protein [Function unknown]; Region: COG2149 476213010981 putative transporter; Validated; Region: PRK03818 476213010982 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 476213010983 TrkA-C domain; Region: TrkA_C; pfam02080 476213010984 TrkA-C domain; Region: TrkA_C; pfam02080 476213010985 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 476213010986 Integrase core domain; Region: rve; pfam00665 476213010987 Integrase core domain; Region: rve_3; pfam13683 476213010988 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 476213010989 Helix-turn-helix domain; Region: HTH_28; pfam13518 476213010990 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 476213010991 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 476213010992 putative dimer interface [polypeptide binding]; other site 476213010993 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 476213010994 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 476213010995 putative dimer interface [polypeptide binding]; other site 476213010996 hypothetical protein; Provisional; Region: PRK11616 476213010997 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 476213010998 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 476213010999 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 476213011000 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 476213011001 binding surface 476213011002 TPR motif; other site 476213011003 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 476213011004 catalytic residues [active] 476213011005 central insert; other site 476213011006 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 476213011007 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150 476213011008 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 476213011009 heme exporter protein CcmC; Region: ccmC; TIGR01191 476213011010 heme exporter protein CcmB; Region: ccmB; TIGR01190 476213011011 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 476213011012 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 476213011013 Walker A/P-loop; other site 476213011014 ATP binding site [chemical binding]; other site 476213011015 Q-loop/lid; other site 476213011016 ABC transporter signature motif; other site 476213011017 Walker B; other site 476213011018 D-loop; other site 476213011019 H-loop/switch region; other site 476213011020 Haem-binding domain; Region: Haem_bd; pfam14376 476213011021 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 476213011022 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 476213011023 chaperone protein TorD; Validated; Region: torD; PRK04976 476213011024 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 476213011025 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 476213011026 molybdopterin cofactor binding site [chemical binding]; other site 476213011027 substrate binding site [chemical binding]; other site 476213011028 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 476213011029 molybdopterin cofactor binding site; other site 476213011030 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 476213011031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 476213011032 active site 476213011033 phosphorylation site [posttranslational modification] 476213011034 intermolecular recognition site; other site 476213011035 dimerization interface [polypeptide binding]; other site 476213011036 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 476213011037 DNA binding site [nucleotide binding] 476213011038 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 476213011039 HAMP domain; Region: HAMP; pfam00672 476213011040 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 476213011041 dimer interface [polypeptide binding]; other site 476213011042 phosphorylation site [posttranslational modification] 476213011043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 476213011044 ATP binding site [chemical binding]; other site 476213011045 Mg2+ binding site [ion binding]; other site 476213011046 G-X-G motif; other site 476213011047 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 476213011048 active site 476213011049 phosphorylation site [posttranslational modification] 476213011050 intermolecular recognition site; other site 476213011051 dimerization interface [polypeptide binding]; other site 476213011052 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 476213011053 putative binding surface; other site 476213011054 active site 476213011055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213011056 D-galactonate transporter; Region: 2A0114; TIGR00893 476213011057 putative substrate translocation pore; other site 476213011058 galactonate dehydratase; Provisional; Region: PRK14017 476213011059 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 476213011060 putative active site pocket [active] 476213011061 putative metal binding site [ion binding]; other site 476213011062 Entner-Doudoroff aldolase; Region: eda; TIGR01182 476213011063 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 476213011064 active site 476213011065 intersubunit interface [polypeptide binding]; other site 476213011066 catalytic residue [active] 476213011067 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 476213011068 Transcriptional regulators [Transcription]; Region: FadR; COG2186 476213011069 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 476213011070 DNA-binding site [nucleotide binding]; DNA binding site 476213011071 FCD domain; Region: FCD; pfam07729 476213011072 sugar phosphate phosphatase; Provisional; Region: PRK10513 476213011073 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 476213011074 active site 476213011075 motif I; other site 476213011076 motif II; other site 476213011077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213011078 D-galactonate transporter; Region: 2A0114; TIGR00893 476213011079 putative substrate translocation pore; other site 476213011080 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 476213011081 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 476213011082 active site pocket [active] 476213011083 Transcriptional regulator [Transcription]; Region: LysR; COG0583 476213011084 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 476213011085 putative dimerization interface [polypeptide binding]; other site 476213011086 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 476213011087 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 476213011088 ATP binding site [chemical binding]; other site 476213011089 Mg2+ binding site [ion binding]; other site 476213011090 G-X-G motif; other site 476213011091 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 476213011092 anchoring element; other site 476213011093 dimer interface [polypeptide binding]; other site 476213011094 ATP binding site [chemical binding]; other site 476213011095 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 476213011096 active site 476213011097 putative metal-binding site [ion binding]; other site 476213011098 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 476213011099 recF protein; Region: recf; TIGR00611 476213011100 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 476213011101 Walker A/P-loop; other site 476213011102 ATP binding site [chemical binding]; other site 476213011103 Q-loop/lid; other site 476213011104 ABC transporter signature motif; other site 476213011105 Walker B; other site 476213011106 D-loop; other site 476213011107 H-loop/switch region; other site 476213011108 DNA polymerase III subunit beta; Validated; Region: PRK05643 476213011109 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 476213011110 putative DNA binding surface [nucleotide binding]; other site 476213011111 dimer interface [polypeptide binding]; other site 476213011112 beta-clamp/clamp loader binding surface; other site 476213011113 beta-clamp/translesion DNA polymerase binding surface; other site 476213011114 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 476213011115 DnaA N-terminal domain; Region: DnaA_N; pfam11638 476213011116 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 476213011117 Walker A motif; other site 476213011118 ATP binding site [chemical binding]; other site 476213011119 Walker B motif; other site 476213011120 arginine finger; other site 476213011121 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 476213011122 DnaA box-binding interface [nucleotide binding]; other site 476213011123 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 476213011124 ribonuclease P; Reviewed; Region: rnpA; PRK01732 476213011125 hypothetical protein; Validated; Region: PRK00041 476213011126 membrane protein insertase; Provisional; Region: PRK01318 476213011127 YidC periplasmic domain; Region: YidC_periplas; pfam14849 476213011128 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 476213011129 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 476213011130 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 476213011131 trmE is a tRNA modification GTPase; Region: trmE; cd04164 476213011132 G1 box; other site 476213011133 GTP/Mg2+ binding site [chemical binding]; other site 476213011134 Switch I region; other site 476213011135 G2 box; other site 476213011136 Switch II region; other site 476213011137 G3 box; other site 476213011138 G4 box; other site 476213011139 G5 box; other site 476213011140 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 476213011141 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 476213011142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213011143 putative substrate translocation pore; other site 476213011144 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 476213011145 Predicted flavoprotein [General function prediction only]; Region: COG0431 476213011146 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 476213011147 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 476213011148 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 476213011149 active site 476213011150 motif I; other site 476213011151 motif II; other site 476213011152 transcriptional regulator PhoU; Provisional; Region: PRK11115 476213011153 PhoU domain; Region: PhoU; pfam01895 476213011154 PhoU domain; Region: PhoU; pfam01895 476213011155 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 476213011156 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 476213011157 Walker A/P-loop; other site 476213011158 ATP binding site [chemical binding]; other site 476213011159 Q-loop/lid; other site 476213011160 ABC transporter signature motif; other site 476213011161 Walker B; other site 476213011162 D-loop; other site 476213011163 H-loop/switch region; other site 476213011164 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 476213011165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213011166 dimer interface [polypeptide binding]; other site 476213011167 conserved gate region; other site 476213011168 putative PBP binding loops; other site 476213011169 ABC-ATPase subunit interface; other site 476213011170 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 476213011171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213011172 dimer interface [polypeptide binding]; other site 476213011173 conserved gate region; other site 476213011174 putative PBP binding loops; other site 476213011175 ABC-ATPase subunit interface; other site 476213011176 phosphate ABC transporter periplasmic substrate-binding protein PstS; Provisional; Region: PRK10918 476213011177 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 476213011178 substrate binding pocket [chemical binding]; other site 476213011179 membrane-bound complex binding site; other site 476213011180 hinge residues; other site 476213011181 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 476213011182 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 476213011183 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 476213011184 shikimate binding site; other site 476213011185 NAD(P) binding site [chemical binding]; other site 476213011186 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 476213011187 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 476213011188 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 476213011189 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 476213011190 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 476213011191 glutaminase active site [active] 476213011192 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 476213011193 dimer interface [polypeptide binding]; other site 476213011194 active site 476213011195 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 476213011196 dimer interface [polypeptide binding]; other site 476213011197 active site 476213011198 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 476213011199 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 476213011200 Substrate binding site; other site 476213011201 Mg++ binding site; other site 476213011202 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 476213011203 active site 476213011204 substrate binding site [chemical binding]; other site 476213011205 CoA binding site [chemical binding]; other site 476213011206 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 476213011207 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 476213011208 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 476213011209 gamma subunit interface [polypeptide binding]; other site 476213011210 epsilon subunit interface [polypeptide binding]; other site 476213011211 LBP interface [polypeptide binding]; other site 476213011212 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 476213011213 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 476213011214 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 476213011215 alpha subunit interaction interface [polypeptide binding]; other site 476213011216 Walker A motif; other site 476213011217 ATP binding site [chemical binding]; other site 476213011218 Walker B motif; other site 476213011219 inhibitor binding site; inhibition site 476213011220 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 476213011221 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 476213011222 core domain interface [polypeptide binding]; other site 476213011223 delta subunit interface [polypeptide binding]; other site 476213011224 epsilon subunit interface [polypeptide binding]; other site 476213011225 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 476213011226 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 476213011227 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 476213011228 beta subunit interaction interface [polypeptide binding]; other site 476213011229 Walker A motif; other site 476213011230 ATP binding site [chemical binding]; other site 476213011231 Walker B motif; other site 476213011232 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 476213011233 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 476213011234 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 476213011235 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 476213011236 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 476213011237 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 476213011238 ATP synthase I chain; Region: ATP_synt_I; cl09170 476213011239 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 476213011240 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 476213011241 S-adenosylmethionine binding site [chemical binding]; other site 476213011242 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 476213011243 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 476213011244 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 476213011245 FMN-binding protein MioC; Provisional; Region: PRK09004 476213011246 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 476213011247 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 476213011248 putative DNA binding site [nucleotide binding]; other site 476213011249 putative Zn2+ binding site [ion binding]; other site 476213011250 AsnC family; Region: AsnC_trans_reg; pfam01037 476213011251 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 476213011252 dimer interface [polypeptide binding]; other site 476213011253 active site 476213011254 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2425 476213011255 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 476213011256 metal ion-dependent adhesion site (MIDAS); other site 476213011257 regulatory ATPase RavA; Provisional; Region: PRK13531 476213011258 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 476213011259 Walker A motif; other site 476213011260 ATP binding site [chemical binding]; other site 476213011261 Walker B motif; other site 476213011262 arginine finger; other site 476213011263 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 476213011264 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 476213011265 D-ribose pyranase; Provisional; Region: PRK11797 476213011266 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 476213011267 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 476213011268 Walker A/P-loop; other site 476213011269 ATP binding site [chemical binding]; other site 476213011270 Q-loop/lid; other site 476213011271 ABC transporter signature motif; other site 476213011272 Walker B; other site 476213011273 D-loop; other site 476213011274 H-loop/switch region; other site 476213011275 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 476213011276 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 476213011277 TM-ABC transporter signature motif; other site 476213011278 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 476213011279 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 476213011280 ligand binding site [chemical binding]; other site 476213011281 dimerization interface [polypeptide binding]; other site 476213011282 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 476213011283 substrate binding site [chemical binding]; other site 476213011284 dimer interface [polypeptide binding]; other site 476213011285 ATP binding site [chemical binding]; other site 476213011286 transcriptional repressor RbsR; Provisional; Region: PRK10423 476213011287 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 476213011288 DNA binding site [nucleotide binding] 476213011289 domain linker motif; other site 476213011290 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 476213011291 dimerization interface [polypeptide binding]; other site 476213011292 ligand binding site [chemical binding]; other site 476213011293 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213011294 putative transporter; Provisional; Region: PRK10504 476213011295 putative substrate translocation pore; other site 476213011296 Transcriptional regulators [Transcription]; Region: FadR; COG2186 476213011297 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 476213011298 DNA-binding site [nucleotide binding]; DNA binding site 476213011299 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 476213011300 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 476213011301 FAD binding domain; Region: FAD_binding_4; pfam01565 476213011302 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 476213011303 Biotin operon repressor [Transcription]; Region: BirA; COG1654 476213011304 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 476213011305 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 476213011306 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 476213011307 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 476213011308 ATP-binding site [chemical binding]; other site 476213011309 CoA-binding site [chemical binding]; other site 476213011310 Mg2+-binding site [ion binding]; other site 476213011311 elongation factor Tu; Reviewed; Region: PRK00049 476213011312 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 476213011313 G1 box; other site 476213011314 GEF interaction site [polypeptide binding]; other site 476213011315 GTP/Mg2+ binding site [chemical binding]; other site 476213011316 Switch I region; other site 476213011317 G2 box; other site 476213011318 G3 box; other site 476213011319 Switch II region; other site 476213011320 G4 box; other site 476213011321 G5 box; other site 476213011322 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 476213011323 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 476213011324 Antibiotic Binding Site [chemical binding]; other site 476213011325 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 476213011326 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 476213011327 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 476213011328 putative homodimer interface [polypeptide binding]; other site 476213011329 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 476213011330 heterodimer interface [polypeptide binding]; other site 476213011331 homodimer interface [polypeptide binding]; other site 476213011332 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 476213011333 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 476213011334 23S rRNA interface [nucleotide binding]; other site 476213011335 L7/L12 interface [polypeptide binding]; other site 476213011336 putative thiostrepton binding site; other site 476213011337 L25 interface [polypeptide binding]; other site 476213011338 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 476213011339 mRNA/rRNA interface [nucleotide binding]; other site 476213011340 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 476213011341 23S rRNA interface [nucleotide binding]; other site 476213011342 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 476213011343 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 476213011344 core dimer interface [polypeptide binding]; other site 476213011345 peripheral dimer interface [polypeptide binding]; other site 476213011346 L10 interface [polypeptide binding]; other site 476213011347 L11 interface [polypeptide binding]; other site 476213011348 putative EF-Tu interaction site [polypeptide binding]; other site 476213011349 putative EF-G interaction site [polypeptide binding]; other site 476213011350 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 476213011351 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 476213011352 RPB12 interaction site [polypeptide binding]; other site 476213011353 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl19478 476213011354 RPB1 interaction site [polypeptide binding]; other site 476213011355 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 476213011356 RPB10 interaction site [polypeptide binding]; other site 476213011357 RPB11 interaction site [polypeptide binding]; other site 476213011358 RPB3 interaction site [polypeptide binding]; other site 476213011359 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 476213011360 beta and beta' interface [polypeptide binding]; other site 476213011361 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 476213011362 beta' and sigma factor interface [polypeptide binding]; other site 476213011363 Zn-binding [ion binding]; other site 476213011364 active site region [active] 476213011365 catalytic site [active] 476213011366 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 476213011367 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 476213011368 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 476213011369 G-loop; other site 476213011370 DNA binding site [nucleotide binding] 476213011371 type III secretion system protein; Provisional; Region: PRK15384 476213011372 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 476213011373 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 476213011374 FeS/SAM binding site; other site 476213011375 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 476213011376 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 476213011377 ThiS interaction site; other site 476213011378 putative active site [active] 476213011379 tetramer interface [polypeptide binding]; other site 476213011380 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 476213011381 thiS-thiF/thiG interaction site; other site 476213011382 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 476213011383 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 476213011384 ATP binding site [chemical binding]; other site 476213011385 substrate interface [chemical binding]; other site 476213011386 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 476213011387 thiamine phosphate binding site [chemical binding]; other site 476213011388 active site 476213011389 pyrophosphate binding site [ion binding]; other site 476213011390 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 476213011391 ThiC-associated domain; Region: ThiC-associated; pfam13667 476213011392 ThiC family; Region: ThiC; pfam01964 476213011393 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 476213011394 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 476213011395 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 476213011396 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 476213011397 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 476213011398 putative NADH binding site [chemical binding]; other site 476213011399 putative active site [active] 476213011400 nudix motif; other site 476213011401 putative metal binding site [ion binding]; other site 476213011402 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 476213011403 substrate binding site [chemical binding]; other site 476213011404 active site 476213011405 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 476213011406 Active_site [active] 476213011407 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 476213011408 histone-like DNA-binding protein HU; Region: HU; cd13831 476213011409 dimer interface [polypeptide binding]; other site 476213011410 DNA binding site [nucleotide binding] 476213011411 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 476213011412 zinc resistance protein; Provisional; Region: zraP; PRK11546 476213011413 dimer interface [polypeptide binding]; other site 476213011414 sensor protein ZraS; Provisional; Region: PRK10364 476213011415 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 476213011416 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 476213011417 dimer interface [polypeptide binding]; other site 476213011418 phosphorylation site [posttranslational modification] 476213011419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 476213011420 ATP binding site [chemical binding]; other site 476213011421 Mg2+ binding site [ion binding]; other site 476213011422 G-X-G motif; other site 476213011423 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 476213011424 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 476213011425 active site 476213011426 phosphorylation site [posttranslational modification] 476213011427 intermolecular recognition site; other site 476213011428 dimerization interface [polypeptide binding]; other site 476213011429 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 476213011430 Walker A motif; other site 476213011431 ATP binding site [chemical binding]; other site 476213011432 Walker B motif; other site 476213011433 arginine finger; other site 476213011434 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 476213011435 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 476213011436 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 476213011437 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 476213011438 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 476213011439 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 476213011440 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 476213011441 purine monophosphate binding site [chemical binding]; other site 476213011442 dimer interface [polypeptide binding]; other site 476213011443 putative catalytic residues [active] 476213011444 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 476213011445 transcriptional regulator HdfR; Provisional; Region: PRK03601 476213011446 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213011447 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 476213011448 dimerization interface [polypeptide binding]; other site 476213011449 hypothetical protein; Provisional; Region: PRK11027 476213011450 putative ATP-dependent protease; Provisional; Region: PRK09862 476213011451 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 476213011452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 476213011453 Walker A motif; other site 476213011454 ATP binding site [chemical binding]; other site 476213011455 Walker B motif; other site 476213011456 arginine finger; other site 476213011457 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 476213011458 ilvG operon leader peptide; Provisional; Region: PRK10424 476213011459 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 476213011460 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 476213011461 PYR/PP interface [polypeptide binding]; other site 476213011462 dimer interface [polypeptide binding]; other site 476213011463 TPP binding site [chemical binding]; other site 476213011464 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 476213011465 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 476213011466 TPP-binding site [chemical binding]; other site 476213011467 dimer interface [polypeptide binding]; other site 476213011468 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 476213011469 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 476213011470 homodimer interface [polypeptide binding]; other site 476213011471 substrate-cofactor binding pocket; other site 476213011472 catalytic residue [active] 476213011473 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 476213011474 threonine dehydratase; Reviewed; Region: PRK09224 476213011475 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 476213011476 tetramer interface [polypeptide binding]; other site 476213011477 pyridoxal 5'-phosphate binding site [chemical binding]; other site 476213011478 catalytic residue [active] 476213011479 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 476213011480 putative Ile/Val binding site [chemical binding]; other site 476213011481 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 476213011482 putative Ile/Val binding site [chemical binding]; other site 476213011483 Phage-related protein [Function unknown]; Region: COG4679 476213011484 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 476213011485 non-specific DNA binding site [nucleotide binding]; other site 476213011486 salt bridge; other site 476213011487 sequence-specific DNA binding site [nucleotide binding]; other site 476213011488 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213011489 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 476213011490 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 476213011491 putative dimerization interface [polypeptide binding]; other site 476213011492 ketol-acid reductoisomerase; Validated; Region: PRK05225 476213011493 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 476213011494 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 476213011495 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 476213011496 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 476213011497 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 476213011498 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 476213011499 Part of AAA domain; Region: AAA_19; pfam13245 476213011500 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 476213011501 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 476213011502 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 476213011503 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 476213011504 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 476213011505 ATP binding site [chemical binding]; other site 476213011506 Mg++ binding site [ion binding]; other site 476213011507 motif III; other site 476213011508 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 476213011509 nucleotide binding region [chemical binding]; other site 476213011510 ATP-binding site [chemical binding]; other site 476213011511 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 476213011512 catalytic residues [active] 476213011513 transcription termination factor Rho; Provisional; Region: rho; PRK09376 476213011514 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 476213011515 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 476213011516 RNA binding site [nucleotide binding]; other site 476213011517 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 476213011518 multimer interface [polypeptide binding]; other site 476213011519 Walker A motif; other site 476213011520 ATP binding site [chemical binding]; other site 476213011521 Walker B motif; other site 476213011522 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 476213011523 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 476213011524 Mg++ binding site [ion binding]; other site 476213011525 putative catalytic motif [active] 476213011526 substrate binding site [chemical binding]; other site 476213011527 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 476213011528 Chain length determinant protein; Region: Wzz; pfam02706 476213011529 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 476213011530 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 476213011531 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 476213011532 active site 476213011533 homodimer interface [polypeptide binding]; other site 476213011534 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 476213011535 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 476213011536 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 476213011537 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 476213011538 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 476213011539 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 476213011540 NAD binding site [chemical binding]; other site 476213011541 substrate binding site [chemical binding]; other site 476213011542 homodimer interface [polypeptide binding]; other site 476213011543 active site 476213011544 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 476213011545 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 476213011546 substrate binding site; other site 476213011547 tetramer interface; other site 476213011548 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 476213011549 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 476213011550 inhibitor-cofactor binding pocket; inhibition site 476213011551 pyridoxal 5'-phosphate binding site [chemical binding]; other site 476213011552 catalytic residue [active] 476213011553 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 476213011554 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 476213011555 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 476213011556 putative common antigen polymerase; Provisional; Region: PRK02975 476213011557 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 476213011558 putative transport protein YifK; Provisional; Region: PRK10746 476213011559 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 476213011560 HemY protein N-terminus; Region: HemY_N; pfam07219 476213011561 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 476213011562 binding surface 476213011563 TPR motif; other site 476213011564 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 476213011565 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 476213011566 active site 476213011567 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 476213011568 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 476213011569 domain interfaces; other site 476213011570 active site 476213011571 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 476213011572 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 476213011573 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 476213011574 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 476213011575 putative iron binding site [ion binding]; other site 476213011576 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 476213011577 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 476213011578 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 476213011579 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 476213011580 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 476213011581 hypothetical protein; Provisional; Region: PRK10963 476213011582 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 476213011583 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 476213011584 active site 476213011585 Int/Topo IB signature motif; other site 476213011586 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 476213011587 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 476213011588 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 476213011589 motif II; other site 476213011590 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 476213011591 Part of AAA domain; Region: AAA_19; pfam13245 476213011592 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 476213011593 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 476213011594 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 476213011595 Cl binding site [ion binding]; other site 476213011596 oligomer interface [polypeptide binding]; other site 476213011597 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 476213011598 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 476213011599 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 476213011600 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 476213011601 CoenzymeA binding site [chemical binding]; other site 476213011602 subunit interaction site [polypeptide binding]; other site 476213011603 PHB binding site; other site 476213011604 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 476213011605 dimerization interface [polypeptide binding]; other site 476213011606 substrate binding site [chemical binding]; other site 476213011607 active site 476213011608 calcium binding site [ion binding]; other site 476213011609 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 476213011610 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 476213011611 ATP binding site [chemical binding]; other site 476213011612 putative Mg++ binding site [ion binding]; other site 476213011613 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 476213011614 nucleotide binding region [chemical binding]; other site 476213011615 ATP-binding site [chemical binding]; other site 476213011616 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 476213011617 HRDC domain; Region: HRDC; pfam00570 476213011618 threonine efflux system; Provisional; Region: PRK10229 476213011619 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 476213011620 lysophospholipase L2; Provisional; Region: PRK10749 476213011621 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 476213011622 putative hydrolase; Provisional; Region: PRK10976 476213011623 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 476213011624 active site 476213011625 motif I; other site 476213011626 motif II; other site 476213011627 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 476213011628 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 476213011629 EamA-like transporter family; Region: EamA; pfam00892 476213011630 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 476213011631 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213011632 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 476213011633 putative dimerization interface [polypeptide binding]; other site 476213011634 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 476213011635 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 476213011636 THF binding site; other site 476213011637 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 476213011638 substrate binding site [chemical binding]; other site 476213011639 THF binding site; other site 476213011640 zinc-binding site [ion binding]; other site 476213011641 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 476213011642 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 476213011643 uridine phosphorylase; Provisional; Region: PRK11178 476213011644 DNA recombination protein RmuC; Provisional; Region: PRK10361 476213011645 RmuC family; Region: RmuC; pfam02646 476213011646 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 476213011647 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 476213011648 S-adenosylmethionine binding site [chemical binding]; other site 476213011649 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 476213011650 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 476213011651 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 476213011652 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 476213011653 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 476213011654 sec-independent translocase; Provisional; Region: PRK01770 476213011655 sec-independent translocase; Provisional; Region: tatB; PRK00404 476213011656 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 476213011657 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 476213011658 active site 476213011659 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 476213011660 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 476213011661 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 476213011662 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 476213011663 FMN reductase; Validated; Region: fre; PRK08051 476213011664 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 476213011665 FAD binding pocket [chemical binding]; other site 476213011666 FAD binding motif [chemical binding]; other site 476213011667 phosphate binding motif [ion binding]; other site 476213011668 beta-alpha-beta structure motif; other site 476213011669 NAD binding pocket [chemical binding]; other site 476213011670 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 476213011671 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 476213011672 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 476213011673 dimer interface [polypeptide binding]; other site 476213011674 active site 476213011675 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 476213011676 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 476213011677 substrate binding site [chemical binding]; other site 476213011678 oxyanion hole (OAH) forming residues; other site 476213011679 trimer interface [polypeptide binding]; other site 476213011680 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 476213011681 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 476213011682 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 476213011683 proline dipeptidase; Provisional; Region: PRK13607 476213011684 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 476213011685 active site 476213011686 hypothetical protein; Provisional; Region: PRK11568 476213011687 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 476213011688 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 476213011689 potassium transporter; Provisional; Region: PRK10750 476213011690 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 476213011691 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 476213011692 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 476213011693 Walker A motif; other site 476213011694 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 476213011695 GTP binding site; other site 476213011696 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 476213011697 serine/threonine protein kinase; Provisional; Region: PRK11768 476213011698 Phosphotransferase enzyme family; Region: APH; pfam01636 476213011699 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 476213011700 catalytic residues [active] 476213011701 hinge region; other site 476213011702 alpha helical domain; other site 476213011703 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 476213011704 putative acyl-acceptor binding pocket; other site 476213011705 DNA polymerase I; Provisional; Region: PRK05755 476213011706 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 476213011707 active site 476213011708 metal binding site 1 [ion binding]; metal-binding site 476213011709 putative 5' ssDNA interaction site; other site 476213011710 metal binding site 3; metal-binding site 476213011711 metal binding site 2 [ion binding]; metal-binding site 476213011712 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 476213011713 putative DNA binding site [nucleotide binding]; other site 476213011714 putative metal binding site [ion binding]; other site 476213011715 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 476213011716 active site 476213011717 catalytic site [active] 476213011718 substrate binding site [chemical binding]; other site 476213011719 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 476213011720 active site 476213011721 DNA binding site [nucleotide binding] 476213011722 catalytic site [active] 476213011723 Predicted GTPase [General function prediction only]; Region: COG0218 476213011724 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 476213011725 G1 box; other site 476213011726 GTP/Mg2+ binding site [chemical binding]; other site 476213011727 Switch I region; other site 476213011728 G2 box; other site 476213011729 G3 box; other site 476213011730 Switch II region; other site 476213011731 G4 box; other site 476213011732 G5 box; other site 476213011733 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 476213011734 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 476213011735 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 476213011736 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 476213011737 FeS/SAM binding site; other site 476213011738 HemN C-terminal domain; Region: HemN_C; pfam06969 476213011739 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 476213011740 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 476213011741 active site 476213011742 phosphorylation site [posttranslational modification] 476213011743 intermolecular recognition site; other site 476213011744 dimerization interface [polypeptide binding]; other site 476213011745 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 476213011746 Walker A motif; other site 476213011747 ATP binding site [chemical binding]; other site 476213011748 Walker B motif; other site 476213011749 arginine finger; other site 476213011750 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 476213011751 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 476213011752 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 476213011753 putative active site [active] 476213011754 heme pocket [chemical binding]; other site 476213011755 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 476213011756 dimer interface [polypeptide binding]; other site 476213011757 phosphorylation site [posttranslational modification] 476213011758 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 476213011759 ATP binding site [chemical binding]; other site 476213011760 Mg2+ binding site [ion binding]; other site 476213011761 G-X-G motif; other site 476213011762 glutamine synthetase; Provisional; Region: glnA; PRK09469 476213011763 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 476213011764 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 476213011765 GTP-binding protein; Provisional; Region: PRK10218 476213011766 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 476213011767 Switch I region; other site 476213011768 G2 box; other site 476213011769 putative GEF interaction site [polypeptide binding]; other site 476213011770 G3 box; other site 476213011771 Switch II region; other site 476213011772 GTP/Mg2+ binding site [chemical binding]; other site 476213011773 G4 box; other site 476213011774 G5 box; other site 476213011775 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 476213011776 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 476213011777 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 476213011778 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 476213011779 active site 476213011780 motif I; other site 476213011781 motif II; other site 476213011782 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 476213011783 Radical SAM superfamily; Region: Radical_SAM; pfam04055 476213011784 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 476213011785 FeS/SAM binding site; other site 476213011786 coproporphyrinogen III oxidase; Validated; Region: PRK08208 476213011787 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 476213011788 FeS/SAM binding site; other site 476213011789 HemN C-terminal domain; Region: HemN_C; pfam06969 476213011790 Sulfatase; Region: Sulfatase; cl19157 476213011791 ATP-grasp domain; Region: ATP-grasp_4; cl17255 476213011792 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 476213011793 Leucine-rich repeats; other site 476213011794 Substrate binding site [chemical binding]; other site 476213011795 outer membrane porin L; Provisional; Region: ompL; PRK09980 476213011796 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 476213011797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213011798 putative substrate translocation pore; other site 476213011799 putative symporter YagG; Provisional; Region: PRK09669; cl15392 476213011800 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 476213011801 alpha-glucosidase; Provisional; Region: PRK10426 476213011802 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 476213011803 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 476213011804 putative active site [active] 476213011805 putative catalytic site [active] 476213011806 putative aldose-1-epimerase; Provisional; Region: PRK15172 476213011807 active site 476213011808 catalytic residues [active] 476213011809 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 476213011810 dimerization interface [polypeptide binding]; other site 476213011811 putative active cleft [active] 476213011812 Class I aldolases; Region: Aldolase_Class_I; cd00945 476213011813 catalytic residue [active] 476213011814 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 476213011815 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 476213011816 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 476213011817 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 476213011818 substrate binding site [chemical binding]; other site 476213011819 ATP binding site [chemical binding]; other site 476213011820 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 476213011821 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 476213011822 putative DNA binding site [nucleotide binding]; other site 476213011823 putative Zn2+ binding site [ion binding]; other site 476213011824 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 476213011825 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 476213011826 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 476213011827 motif II; other site 476213011828 hypothetical protein; Reviewed; Region: PRK01637 476213011829 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 476213011830 putative active site [active] 476213011831 dimerization interface [polypeptide binding]; other site 476213011832 putative tRNAtyr binding site [nucleotide binding]; other site 476213011833 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 476213011834 Coenzyme A binding pocket [chemical binding]; other site 476213011835 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 476213011836 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 476213011837 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 476213011838 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 476213011839 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 476213011840 Predicted transcriptional regulator [Transcription]; Region: COG2944 476213011841 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 476213011842 non-specific DNA binding site [nucleotide binding]; other site 476213011843 salt bridge; other site 476213011844 sequence-specific DNA binding site [nucleotide binding]; other site 476213011845 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 476213011846 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 476213011847 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 476213011848 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 476213011849 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 476213011850 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 476213011851 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 476213011852 Predicted coiled-coil domain-containing protein (DUF2360); Region: DUF2360; pfam10152 476213011853 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 476213011854 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 476213011855 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 476213011856 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 476213011857 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 476213011858 non-specific DNA binding site [nucleotide binding]; other site 476213011859 salt bridge; other site 476213011860 sequence-specific DNA binding site [nucleotide binding]; other site 476213011861 Cupin domain; Region: Cupin_2; cl17218 476213011862 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 476213011863 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 476213011864 dimer interface [polypeptide binding]; other site 476213011865 active site 476213011866 metal binding site [ion binding]; metal-binding site 476213011867 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 476213011868 intersubunit interface [polypeptide binding]; other site 476213011869 active site 476213011870 Zn2+ binding site [ion binding]; other site 476213011871 L-rhamnose isomerase; Provisional; Region: PRK01076 476213011872 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 476213011873 N- and C-terminal domain interface [polypeptide binding]; other site 476213011874 active site 476213011875 putative catalytic site [active] 476213011876 metal binding site [ion binding]; metal-binding site 476213011877 ATP binding site [chemical binding]; other site 476213011878 rhamnulokinase; Provisional; Region: rhaB; PRK10640 476213011879 carbohydrate binding site [chemical binding]; other site 476213011880 transcriptional activator RhaS; Provisional; Region: PRK13503 476213011881 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 476213011882 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213011883 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213011884 transcriptional activator RhaR; Provisional; Region: PRK13502 476213011885 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 476213011886 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213011887 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213011888 L-rhamnose-proton symport protein (RhaT); Region: RhaT; pfam06379 476213011889 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178 476213011890 DctM-like transporters; Region: DctM; pfam06808 476213011891 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 476213011892 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 476213011893 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 476213011894 superoxide dismutase; Provisional; Region: PRK10925 476213011895 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 476213011896 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 476213011897 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 476213011898 MOSC domain; Region: MOSC; pfam03473 476213011899 3-alpha domain; Region: 3-alpha; pfam03475 476213011900 SnoaL-like domain; Region: SnoaL_2; pfam12680 476213011901 two-component sensor protein; Provisional; Region: cpxA; PRK09470 476213011902 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 476213011903 dimerization interface [polypeptide binding]; other site 476213011904 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 476213011905 dimer interface [polypeptide binding]; other site 476213011906 phosphorylation site [posttranslational modification] 476213011907 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 476213011908 ATP binding site [chemical binding]; other site 476213011909 Mg2+ binding site [ion binding]; other site 476213011910 G-X-G motif; other site 476213011911 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 476213011912 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 476213011913 active site 476213011914 intermolecular recognition site; other site 476213011915 dimerization interface [polypeptide binding]; other site 476213011916 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 476213011917 DNA binding site [nucleotide binding] 476213011918 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 476213011919 dimer interface [polypeptide binding]; other site 476213011920 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 476213011921 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 476213011922 active site 476213011923 ADP/pyrophosphate binding site [chemical binding]; other site 476213011924 dimerization interface [polypeptide binding]; other site 476213011925 allosteric effector site; other site 476213011926 fructose-1,6-bisphosphate binding site; other site 476213011927 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 476213011928 substrate binding pocket [chemical binding]; other site 476213011929 membrane-bound complex binding site; other site 476213011930 hinge residues; other site 476213011931 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 476213011932 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 476213011933 putative substrate binding site [chemical binding]; other site 476213011934 putative ATP binding site [chemical binding]; other site 476213011935 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 476213011936 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 476213011937 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 476213011938 DNA-binding site [nucleotide binding]; DNA binding site 476213011939 Alanine racemase, C-terminal domain; Region: Ala_racemase_C; cl08293 476213011940 UTRA domain; Region: UTRA; pfam07702 476213011941 CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934 476213011942 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 476213011943 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 476213011944 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 476213011945 putative N- and C-terminal domain interface [polypeptide binding]; other site 476213011946 putative active site [active] 476213011947 putative MgATP binding site [chemical binding]; other site 476213011948 catalytic site [active] 476213011949 metal binding site [ion binding]; metal-binding site 476213011950 putative carbohydrate binding site [chemical binding]; other site 476213011951 transcriptional regulator LsrR; Provisional; Region: PRK15418 476213011952 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 476213011953 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 476213011954 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 476213011955 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 476213011956 Walker A/P-loop; other site 476213011957 ATP binding site [chemical binding]; other site 476213011958 Q-loop/lid; other site 476213011959 ABC transporter signature motif; other site 476213011960 Walker B; other site 476213011961 D-loop; other site 476213011962 H-loop/switch region; other site 476213011963 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 476213011964 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 476213011965 TM-ABC transporter signature motif; other site 476213011966 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 476213011967 TM-ABC transporter signature motif; other site 476213011968 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 476213011969 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 476213011970 ligand binding site [chemical binding]; other site 476213011971 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 476213011972 putative active site; other site 476213011973 catalytic residue [active] 476213011974 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 476213011975 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 476213011976 substrate binding site [chemical binding]; other site 476213011977 hexamer interface [polypeptide binding]; other site 476213011978 metal binding site [ion binding]; metal-binding site 476213011979 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 476213011980 substrate binding site [chemical binding]; other site 476213011981 dimer interface [polypeptide binding]; other site 476213011982 catalytic triad [active] 476213011983 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 476213011984 Predicted membrane protein [Function unknown]; Region: COG3152 476213011985 ferredoxin-NADP reductase; Provisional; Region: PRK10926 476213011986 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 476213011987 FAD binding pocket [chemical binding]; other site 476213011988 FAD binding motif [chemical binding]; other site 476213011989 phosphate binding motif [ion binding]; other site 476213011990 beta-alpha-beta structure motif; other site 476213011991 NAD binding pocket [chemical binding]; other site 476213011992 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 476213011993 putative active site [active] 476213011994 glycerol kinase; Provisional; Region: glpK; PRK00047 476213011995 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 476213011996 N- and C-terminal domain interface [polypeptide binding]; other site 476213011997 active site 476213011998 MgATP binding site [chemical binding]; other site 476213011999 catalytic site [active] 476213012000 metal binding site [ion binding]; metal-binding site 476213012001 glycerol binding site [chemical binding]; other site 476213012002 homotetramer interface [polypeptide binding]; other site 476213012003 homodimer interface [polypeptide binding]; other site 476213012004 FBP binding site [chemical binding]; other site 476213012005 protein IIAGlc interface [polypeptide binding]; other site 476213012006 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 476213012007 amphipathic channel; other site 476213012008 Asn-Pro-Ala signature motifs; other site 476213012009 septal ring assembly protein ZapB; Provisional; Region: PRK15422 476213012010 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 476213012011 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 476213012012 putative active site [active] 476213012013 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 476213012014 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 476213012015 Walker A motif; other site 476213012016 ATP binding site [chemical binding]; other site 476213012017 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 476213012018 Walker B motif; other site 476213012019 arginine finger; other site 476213012020 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 476213012021 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 476213012022 active site 476213012023 HslU subunit interaction site [polypeptide binding]; other site 476213012024 essential cell division protein FtsN; Provisional; Region: PRK10927 476213012025 Sporulation related domain; Region: SPOR; pfam05036 476213012026 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 476213012027 DNA binding site [nucleotide binding] 476213012028 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 476213012029 domain linker motif; other site 476213012030 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 476213012031 dimerization interface [polypeptide binding]; other site 476213012032 ligand binding site [chemical binding]; other site 476213012033 primosome assembly protein PriA; Validated; Region: PRK05580 476213012034 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 476213012035 ATP binding site [chemical binding]; other site 476213012036 putative Mg++ binding site [ion binding]; other site 476213012037 helicase superfamily c-terminal domain; Region: HELICc; smart00490 476213012038 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 476213012039 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 476213012040 Helix-turn-helix domain; Region: HTH_28; pfam13518 476213012041 Integrase core domain; Region: rve; pfam00665 476213012042 Integrase core domain; Region: rve_3; pfam13683 476213012043 conserved hypothetical protein; Region: chp_urease_rgn; TIGR02117 476213012044 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 476213012045 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 476213012046 dimerization interface [polypeptide binding]; other site 476213012047 DNA binding site [nucleotide binding] 476213012048 corepressor binding sites; other site 476213012049 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 476213012050 homodimer interface [polypeptide binding]; other site 476213012051 substrate-cofactor binding pocket; other site 476213012052 pyridoxal 5'-phosphate binding site [chemical binding]; other site 476213012053 catalytic residue [active] 476213012054 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 476213012055 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 476213012056 putative catalytic residues [active] 476213012057 putative nucleotide binding site [chemical binding]; other site 476213012058 putative aspartate binding site [chemical binding]; other site 476213012059 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 476213012060 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 476213012061 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 476213012062 mechanosensitive channel MscS; Provisional; Region: PRK10334 476213012063 Conserved TM helix; Region: TM_helix; pfam05552 476213012064 Mechanosensitive ion channel; Region: MS_channel; pfam00924 476213012065 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 476213012066 Insertion element protein; Region: Ins_element1; pfam03811 476213012067 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 476213012068 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 476213012069 active site 476213012070 metal binding site [ion binding]; metal-binding site 476213012071 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 476213012072 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 476213012073 FAD binding site [chemical binding]; other site 476213012074 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 476213012075 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 476213012076 heme binding site [chemical binding]; other site 476213012077 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 476213012078 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 476213012079 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 476213012080 dimer interface [polypeptide binding]; other site 476213012081 active site 476213012082 metal binding site [ion binding]; metal-binding site 476213012083 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 476213012084 active site 476213012085 intersubunit interactions; other site 476213012086 catalytic residue [active] 476213012087 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 476213012088 dimerization domain swap beta strand [polypeptide binding]; other site 476213012089 regulatory protein interface [polypeptide binding]; other site 476213012090 active site 476213012091 regulatory phosphorylation site [posttranslational modification]; other site 476213012092 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 476213012093 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 476213012094 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 476213012095 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 476213012096 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 476213012097 active site 476213012098 phosphorylation site [posttranslational modification] 476213012099 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 476213012100 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 476213012101 active site 476213012102 P-loop; other site 476213012103 phosphorylation site [posttranslational modification] 476213012104 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 476213012105 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 476213012106 dimer interface [polypeptide binding]; other site 476213012107 active site 476213012108 glycine loop; other site 476213012109 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 476213012110 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 476213012111 FeS/SAM binding site; other site 476213012112 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 476213012113 active site 476213012114 P-loop; other site 476213012115 phosphorylation site [posttranslational modification] 476213012116 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213012117 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 476213012118 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213012119 hypothetical protein; Provisional; Region: PRK10649 476213012120 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 476213012121 Sulfatase; Region: Sulfatase; pfam00884 476213012122 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 476213012123 acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892 476213012124 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 476213012125 metal binding site [ion binding]; metal-binding site 476213012126 putative dimer interface [polypeptide binding]; other site 476213012127 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 476213012128 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 476213012129 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 476213012130 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 476213012131 nucleotide binding site [chemical binding]; other site 476213012132 N-acetyl-L-glutamate binding site [chemical binding]; other site 476213012133 argininosuccinate lyase; Provisional; Region: PRK04833 476213012134 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 476213012135 active sites [active] 476213012136 tetramer interface [polypeptide binding]; other site 476213012137 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 476213012138 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213012139 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 476213012140 dimerization interface [polypeptide binding]; other site 476213012141 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 476213012142 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 476213012143 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 476213012144 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 476213012145 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 476213012146 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 476213012147 hypothetical protein; Provisional; Region: PRK11056 476213012148 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 476213012149 Protein of unknown function (DUF3164); Region: DUF3164; pfam11363 476213012150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 476213012151 S-adenosylmethionine binding site [chemical binding]; other site 476213012152 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 476213012153 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 476213012154 N-terminal plug; other site 476213012155 ligand-binding site [chemical binding]; other site 476213012156 glutamate racemase; Provisional; Region: PRK00865 476213012157 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 476213012158 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 476213012159 Coenzyme A binding pocket [chemical binding]; other site 476213012160 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 476213012161 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 476213012162 proposed active site lysine [active] 476213012163 conserved cys residue [active] 476213012164 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 476213012165 active site 476213012166 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 476213012167 tetramer interface [polypeptide binding]; other site 476213012168 active site 476213012169 Mg2+/Mn2+ binding site [ion binding]; other site 476213012170 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 476213012171 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 476213012172 transcriptional repressor IclR; Provisional; Region: PRK11569 476213012173 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 476213012174 Bacterial transcriptional regulator; Region: IclR; pfam01614 476213012175 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 476213012176 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 476213012177 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 476213012178 substrate binding pocket [chemical binding]; other site 476213012179 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 476213012180 B12 binding site [chemical binding]; other site 476213012181 cobalt ligand [ion binding]; other site 476213012182 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 476213012183 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 476213012184 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 476213012185 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 476213012186 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 476213012187 active site pocket [active] 476213012188 oxyanion hole [active] 476213012189 catalytic triad [active] 476213012190 active site nucleophile [active] 476213012191 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 476213012192 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 476213012193 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 476213012194 RNA binding surface [nucleotide binding]; other site 476213012195 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 476213012196 probable active site [active] 476213012197 hypothetical protein; Provisional; Region: PRK10515 476213012198 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 476213012199 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 476213012200 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 476213012201 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 476213012202 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 476213012203 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 476213012204 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 476213012205 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 476213012206 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 476213012207 Baseplate J-like protein; Region: Baseplate_J; cl01294 476213012208 Phage baseplate assembly protein W [General function prediction only]; Region: COG3628 476213012209 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 476213012210 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 476213012211 Ligand binding site; other site 476213012212 Putative Catalytic site; other site 476213012213 DXD motif; other site 476213012214 Predicted membrane protein [Function unknown]; Region: COG2246 476213012215 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 476213012216 Phage protein D [General function prediction only]; Region: COG3500 476213012217 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 476213012218 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 476213012219 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 476213012220 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 476213012221 Phage tail tube protein FII [General function prediction only]; Region: COG3498 476213012222 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 476213012223 Gp37 protein; Region: Gp37; pfam09646 476213012224 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 476213012225 N-acetyl-D-glucosamine binding site [chemical binding]; other site 476213012226 catalytic residue [active] 476213012227 Protein of unknown function (DUF4063); Region: DUF4063; pfam13272 476213012228 Mor transcription activator family; Region: Mor; pfam08765 476213012229 aspartate kinase III; Validated; Region: PRK09084 476213012230 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 476213012231 nucleotide binding site [chemical binding]; other site 476213012232 substrate binding site [chemical binding]; other site 476213012233 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 476213012234 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 476213012235 dimer interface [polypeptide binding]; other site 476213012236 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 476213012237 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 476213012238 active site 476213012239 dimer interface [polypeptide binding]; other site 476213012240 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 476213012241 dimer interface [polypeptide binding]; other site 476213012242 active site 476213012243 Exopolysaccharide production protein YjbE; Region: YjbE; pfam11106 476213012244 Group 4 capsule polysaccharide formation lipoprotein gfcB; Region: Cap_synth_GfcB; pfam11102 476213012245 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 476213012246 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 476213012247 Predicted membrane protein [Function unknown]; Region: COG3223 476213012248 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 476213012249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213012250 dimer interface [polypeptide binding]; other site 476213012251 conserved gate region; other site 476213012252 putative PBP binding loops; other site 476213012253 ABC-ATPase subunit interface; other site 476213012254 maltose transporter membrane protein; Provisional; Region: malF; PRK10999 476213012255 Maltose transport system permease protein MalF P2 domain; Region: MalF_P2; pfam14785 476213012256 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 476213012257 dimer interface [polypeptide binding]; other site 476213012258 conserved gate region; other site 476213012259 putative PBP binding loops; other site 476213012260 ABC-ATPase subunit interface; other site 476213012261 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 476213012262 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 476213012263 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 476213012264 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 476213012265 Walker A/P-loop; other site 476213012266 ATP binding site [chemical binding]; other site 476213012267 Q-loop/lid; other site 476213012268 ABC transporter signature motif; other site 476213012269 Walker B; other site 476213012270 D-loop; other site 476213012271 H-loop/switch region; other site 476213012272 TOBE domain; Region: TOBE_2; pfam08402 476213012273 maltoporin; Provisional; Region: lamB; PRK09360 476213012274 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 476213012275 trimer interface; other site 476213012276 sugar binding site [chemical binding]; other site 476213012277 maltose regulon periplasmic protein; Provisional; Region: PRK10564 476213012278 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 476213012279 4-Hydroxybenzoate polyprenyltransferase; Region: PT_UbiA_COQ2; cd13959 476213012280 putative active site [active] 476213012281 Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937 476213012282 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 476213012283 putative acyl-acceptor binding pocket; other site 476213012284 Integral membrane diacylglycerol kinase; Region: DAGK_IM; cd14264 476213012285 putative active site [active] 476213012286 trimer interface [polypeptide binding]; other site 476213012287 putative active site [active] 476213012288 Zn binding site [ion binding]; other site 476213012289 LexA repressor; Validated; Region: PRK00215 476213012290 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 476213012291 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 476213012292 Catalytic site [active] 476213012293 hypothetical protein; Provisional; Region: PRK10428 476213012294 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 476213012295 metal binding site 2 [ion binding]; metal-binding site 476213012296 putative DNA binding helix; other site 476213012297 metal binding site 1 [ion binding]; metal-binding site 476213012298 dimer interface [polypeptide binding]; other site 476213012299 structural Zn2+ binding site [ion binding]; other site 476213012300 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 476213012301 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 476213012302 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 476213012303 FMN binding site [chemical binding]; other site 476213012304 active site 476213012305 catalytic residues [active] 476213012306 substrate binding site [chemical binding]; other site 476213012307 phage shock protein G; Reviewed; Region: pspG; PRK09459 476213012308 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 476213012309 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 476213012310 NADP binding site [chemical binding]; other site 476213012311 dimer interface [polypeptide binding]; other site 476213012312 replicative DNA helicase; Provisional; Region: PRK08006 476213012313 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 476213012314 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 476213012315 Walker A motif; other site 476213012316 ATP binding site [chemical binding]; other site 476213012317 Walker B motif; other site 476213012318 DNA binding loops [nucleotide binding] 476213012319 alanine racemase; Reviewed; Region: alr; PRK00053 476213012320 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 476213012321 active site 476213012322 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 476213012323 substrate binding site [chemical binding]; other site 476213012324 catalytic residues [active] 476213012325 dimer interface [polypeptide binding]; other site 476213012326 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 476213012327 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 476213012328 pyridoxal 5'-phosphate binding site [chemical binding]; other site 476213012329 homodimer interface [polypeptide binding]; other site 476213012330 catalytic residue [active] 476213012331 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 476213012332 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 476213012333 active site 476213012334 motif I; other site 476213012335 motif II; other site 476213012336 Uncharacterized conserved protein [Function unknown]; Region: COG0432 476213012337 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 476213012338 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 476213012339 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 476213012340 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 476213012341 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 476213012342 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 476213012343 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 476213012344 dimer interface [polypeptide binding]; other site 476213012345 ssDNA binding site [nucleotide binding]; other site 476213012346 tetramer (dimer of dimers) interface [polypeptide binding]; other site 476213012347 putative single-stranded DNA-binding protein; Region: PHA01740 476213012348 hypothetical protein; Validated; Region: PRK09039 476213012349 Zinc finger-containing protein; Region: zf-C4H2; pfam10146 476213012350 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 476213012351 Outer membrane efflux protein; Region: OEP; pfam02321 476213012352 Outer membrane efflux protein; Region: OEP; pfam02321 476213012353 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 476213012354 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 476213012355 HlyD family secretion protein; Region: HlyD_3; pfam13437 476213012356 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 476213012357 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 476213012358 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 476213012359 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 476213012360 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 476213012361 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 476213012362 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 476213012363 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 476213012364 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 476213012365 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 476213012366 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 476213012367 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 476213012368 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 476213012369 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 476213012370 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 476213012371 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 476213012372 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 476213012373 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 476213012374 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 476213012375 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 476213012376 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 476213012377 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 476213012378 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 476213012379 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 476213012380 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 476213012381 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 476213012382 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 476213012383 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 476213012384 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 476213012385 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 476213012386 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 476213012387 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 476213012388 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 476213012389 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 476213012390 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 476213012391 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 476213012392 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 476213012393 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 476213012394 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 476213012395 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 476213012396 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 476213012397 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 476213012398 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 476213012399 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 476213012400 Bacterial Ig-like domain (group 3); Region: Big_3_2; pfam12245 476213012401 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 476213012402 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 476213012403 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 476213012404 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 476213012405 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 476213012406 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 476213012407 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 476213012408 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 476213012409 Walker A/P-loop; other site 476213012410 ATP binding site [chemical binding]; other site 476213012411 Q-loop/lid; other site 476213012412 ABC transporter signature motif; other site 476213012413 Walker B; other site 476213012414 D-loop; other site 476213012415 H-loop/switch region; other site 476213012416 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 476213012417 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 476213012418 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 476213012419 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 476213012420 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213012421 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 476213012422 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 476213012423 DNA binding residues [nucleotide binding] 476213012424 dimer interface [polypeptide binding]; other site 476213012425 [2Fe-2S] cluster binding site [ion binding]; other site 476213012426 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 476213012427 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 476213012428 putative C-terminal domain interface [polypeptide binding]; other site 476213012429 putative GSH binding site (G-site) [chemical binding]; other site 476213012430 putative dimer interface [polypeptide binding]; other site 476213012431 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 476213012432 putative N-terminal domain interface [polypeptide binding]; other site 476213012433 putative dimer interface [polypeptide binding]; other site 476213012434 putative substrate binding pocket (H-site) [chemical binding]; other site 476213012435 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 476213012436 Sulfate transporter family; Region: Sulfate_transp; cl19250 476213012437 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 476213012438 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 476213012439 Transcriptional regulator [Transcription]; Region: LysR; COG0583 476213012440 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213012441 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 476213012442 putative dimerization interface [polypeptide binding]; other site 476213012443 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 476213012444 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 476213012445 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 476213012446 Na binding site [ion binding]; other site 476213012447 acetyl-CoA synthetase; Provisional; Region: PRK00174 476213012448 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 476213012449 active site 476213012450 CoA binding site [chemical binding]; other site 476213012451 acyl-activating enzyme (AAE) consensus motif; other site 476213012452 AMP binding site [chemical binding]; other site 476213012453 acetate binding site [chemical binding]; other site 476213012454 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 476213012455 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 476213012456 Cytochrome c3; Region: Cytochrom_c3_2; pfam14537 476213012457 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 476213012458 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 476213012459 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 476213012460 heme lyase subunit NrfE; Provisional; Region: PRK10369 476213012461 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 476213012462 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 476213012463 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 476213012464 binding surface 476213012465 TPR motif; other site 476213012466 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 476213012467 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 476213012468 Sel1-like repeats; Region: SEL1; smart00671 476213012469 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 476213012470 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 476213012471 Coenzyme A binding pocket [chemical binding]; other site 476213012472 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 476213012473 dimer interface [polypeptide binding]; other site 476213012474 hypothetical protein; Provisional; Region: PRK10220 476213012475 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 476213012476 PhnA protein; Region: PhnA; pfam03831 476213012477 proline/glycine betaine transporter; Provisional; Region: PRK10642 476213012478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213012479 putative substrate translocation pore; other site 476213012480 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 476213012481 sensor protein BasS/PmrB; Provisional; Region: PRK10755 476213012482 HAMP domain; Region: HAMP; pfam00672 476213012483 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 476213012484 dimer interface [polypeptide binding]; other site 476213012485 phosphorylation site [posttranslational modification] 476213012486 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 476213012487 ATP binding site [chemical binding]; other site 476213012488 Mg2+ binding site [ion binding]; other site 476213012489 G-X-G motif; other site 476213012490 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 476213012491 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 476213012492 active site 476213012493 phosphorylation site [posttranslational modification] 476213012494 intermolecular recognition site; other site 476213012495 dimerization interface [polypeptide binding]; other site 476213012496 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 476213012497 DNA binding site [nucleotide binding] 476213012498 putative metal dependent hydrolase; Provisional; Region: PRK11598 476213012499 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 476213012500 Sulfatase; Region: Sulfatase; pfam00884 476213012501 arginine:agmatin antiporter; Provisional; Region: PRK10644 476213012502 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 476213012503 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213012504 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 476213012505 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213012506 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 476213012507 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213012508 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213012509 alpha-galactosidase; Provisional; Region: PRK15076 476213012510 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 476213012511 NAD binding site [chemical binding]; other site 476213012512 sugar binding site [chemical binding]; other site 476213012513 divalent metal binding site [ion binding]; other site 476213012514 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 476213012515 dimer interface [polypeptide binding]; other site 476213012516 melibiose:sodium symporter; Provisional; Region: PRK10429 476213012517 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 476213012518 fumarate hydratase; Provisional; Region: PRK15389 476213012519 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 476213012520 Fumarase C-terminus; Region: Fumerase_C; pfam05683 476213012521 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 476213012522 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 476213012523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 476213012524 active site 476213012525 phosphorylation site [posttranslational modification] 476213012526 intermolecular recognition site; other site 476213012527 dimerization interface [polypeptide binding]; other site 476213012528 sensory histidine kinase DcuS; Provisional; Region: PRK11086 476213012529 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 476213012530 PAS domain; Region: PAS; smart00091 476213012531 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 476213012532 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 476213012533 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 476213012534 ATP binding site [chemical binding]; other site 476213012535 Mg2+ binding site [ion binding]; other site 476213012536 G-X-G motif; other site 476213012537 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 476213012538 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 476213012539 putative [Fe4-S4] binding site [ion binding]; other site 476213012540 putative molybdopterin cofactor binding site [chemical binding]; other site 476213012541 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 476213012542 putative molybdopterin cofactor binding site; other site 476213012543 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 476213012544 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 476213012545 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 476213012546 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 476213012547 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 476213012548 SdiA-regulated; Region: SdiA-regulated; cd09971 476213012549 putative active site [active] 476213012550 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 476213012551 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 476213012552 DNA binding residues [nucleotide binding] 476213012553 dimerization interface [polypeptide binding]; other site 476213012554 AraC family transcriptional regulator; Provisional; Region: PRK15186 476213012555 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 476213012556 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213012557 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213012558 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 476213012559 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 476213012560 Transposase, Mutator family; Region: Transposase_mut; cl19537 476213012561 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 476213012562 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 476213012563 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 476213012564 P-loop; other site 476213012565 Magnesium ion binding site [ion binding]; other site 476213012566 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 476213012567 replicative DNA helicase; Region: DnaB; TIGR00665 476213012568 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 476213012569 Walker A motif; other site 476213012570 ATP binding site [chemical binding]; other site 476213012571 Walker B motif; other site 476213012572 DNA binding loops [nucleotide binding] 476213012573 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 476213012574 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 476213012575 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 476213012576 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 476213012577 Helix-turn-helix domain; Region: HTH_36; pfam13730 476213012578 integrating conjugative element protein, PFL_4669 family; Region: ICE_PFL4669; TIGR03761 476213012579 DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056 476213012580 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 476213012581 active site 476213012582 putative interdomain interaction site [polypeptide binding]; other site 476213012583 putative metal-binding site [ion binding]; other site 476213012584 putative nucleotide binding site [chemical binding]; other site 476213012585 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 476213012586 domain I; other site 476213012587 DNA binding groove [nucleotide binding] 476213012588 phosphate binding site [ion binding]; other site 476213012589 domain II; other site 476213012590 domain III; other site 476213012591 nucleotide binding site [chemical binding]; other site 476213012592 catalytic site [active] 476213012593 domain IV; other site 476213012594 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 476213012595 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 476213012596 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 476213012597 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 476213012598 dimer interface [polypeptide binding]; other site 476213012599 ssDNA binding site [nucleotide binding]; other site 476213012600 tetramer (dimer of dimers) interface [polypeptide binding]; other site 476213012601 putative single-stranded DNA-binding protein; Region: PHA01740 476213012602 putative transposase; Provisional; Region: PRK09857 476213012603 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 476213012604 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 476213012605 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 476213012606 PilM; Region: PilM; pfam07419 476213012607 Pilin accessory protein (PilO); Region: PAP_PilO; pfam06864 476213012608 type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021 476213012609 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 476213012610 Walker A motif; other site 476213012611 ATP binding site [chemical binding]; other site 476213012612 Walker B motif; other site 476213012613 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 476213012614 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 476213012615 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 476213012616 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 476213012617 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 476213012618 N-acetyl-D-glucosamine binding site [chemical binding]; other site 476213012619 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 476213012620 Restriction endonuclease; Region: Mrr_cat; pfam04471 476213012621 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 476213012622 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 476213012623 integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747 476213012624 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 476213012625 Protein of unknown function (DUF3262); Region: DUF3262; pfam11660 476213012626 integrating conjugative element membrane protein, PFL_4702 family; Region: conj_TIGR03745 476213012627 integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746 476213012628 Protein of unknown function (DUF3438); Region: DUF3438; pfam11920 476213012629 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 476213012630 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 476213012631 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 476213012632 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 476213012633 integrating conjugative element protein, PFL_4709 family; Region: conj_TIGR03757 476213012634 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 476213012635 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 476213012636 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 476213012637 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 476213012638 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 476213012639 Active Sites [active] 476213012640 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 476213012641 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 476213012642 ParB-like nuclease domain; Region: ParB; smart00470 476213012643 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 476213012644 Phage integrase, N-terminal; Region: Phage_int_SAM_2; pfam12834 476213012645 Integrase; Region: Integrase_1; pfam12835 476213012646 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 476213012647 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 476213012648 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 476213012649 Protein of unknown function (DUF3085); Region: DUF3085; pfam11284 476213012650 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 476213012651 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 476213012652 active site 476213012653 DNA binding site [nucleotide binding] 476213012654 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 476213012655 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 476213012656 Catalytic site [active] 476213012657 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 476213012658 hypothetical protein; Provisional; Region: PRK13687 476213012659 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 476213012660 S-adenosylmethionine binding site [chemical binding]; other site 476213012661 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 476213012662 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 476213012663 S-adenosylmethionine binding site [chemical binding]; other site 476213012664 Vi polysaccharide export protein VexE; Provisional; Region: PRK15174 476213012665 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 476213012666 TPR motif; other site 476213012667 binding surface 476213012668 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 476213012669 putative acyl-acceptor binding pocket; other site 476213012670 Vi polysaccharide export inner membrane protein VexD; Provisional; Region: PRK15178 476213012671 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 476213012672 Vi polysaccharide export ATP-binding protein VexC; Provisional; Region: PRK15177 476213012673 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 476213012674 Walker A/P-loop; other site 476213012675 ATP binding site [chemical binding]; other site 476213012676 Q-loop/lid; other site 476213012677 ABC transporter signature motif; other site 476213012678 Walker B; other site 476213012679 D-loop; other site 476213012680 H-loop/switch region; other site 476213012681 Vi polysaccharide export inner membrane protein VexB; Provisional; Region: PRK15176 476213012682 Vi polysaccharide export protein VexA; Provisional; Region: PRK15175 476213012683 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 476213012684 Vi polysaccharide biosynthesis protein TviE; Provisional; Region: PRK15490 476213012685 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 476213012686 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 476213012687 Vi polysaccharide biosynthesis protein TviD; Provisional; Region: PRK15180 476213012688 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 476213012689 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 476213012690 NAD binding site [chemical binding]; other site 476213012691 substrate binding site [chemical binding]; other site 476213012692 homodimer interface [polypeptide binding]; other site 476213012693 active site 476213012694 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 476213012695 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 476213012696 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 476213012697 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 476213012698 Vi polysaccharide biosynthesis protein TviA; Provisional; Region: PRK15183 476213012699 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 476213012700 AAA domain; Region: AAA_22; pfam13401 476213012701 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 476213012702 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 476213012703 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 476213012704 putative transcriptional regulator; Provisional; Region: PRK11640 476213012705 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 476213012706 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 476213012707 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 476213012708 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 476213012709 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 476213012710 DsbD alpha interface [polypeptide binding]; other site 476213012711 catalytic residues [active] 476213012712 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 476213012713 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 476213012714 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 476213012715 Aspartase; Region: Aspartase; cd01357 476213012716 active sites [active] 476213012717 tetramer interface [polypeptide binding]; other site 476213012718 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 476213012719 putative transporter; Provisional; Region: PRK11021 476213012720 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 476213012721 oligomerisation interface [polypeptide binding]; other site 476213012722 mobile loop; other site 476213012723 roof hairpin; other site 476213012724 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 476213012725 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 476213012726 ring oligomerisation interface [polypeptide binding]; other site 476213012727 ATP/Mg binding site [chemical binding]; other site 476213012728 stacking interactions; other site 476213012729 hinge regions; other site 476213012730 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 476213012731 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 476213012732 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 476213012733 FeS/SAM binding site; other site 476213012734 elongation factor P; Validated; Region: PRK00529 476213012735 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 476213012736 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 476213012737 RNA binding site [nucleotide binding]; other site 476213012738 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 476213012739 RNA binding site [nucleotide binding]; other site 476213012740 Predicted small secreted protein [Function unknown]; Region: COG5510 476213012741 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 476213012742 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 476213012743 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 476213012744 DNA binding residues [nucleotide binding] 476213012745 dimerization interface [polypeptide binding]; other site 476213012746 multidrug efflux system protein; Provisional; Region: PRK11431 476213012747 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 476213012748 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 476213012749 Iron-sulfur protein interface; other site 476213012750 proximal quinone binding site [chemical binding]; other site 476213012751 C-subunit interface; other site 476213012752 distal quinone binding site; other site 476213012753 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 476213012754 D-subunit interface [polypeptide binding]; other site 476213012755 Iron-sulfur protein interface; other site 476213012756 proximal quinone binding site [chemical binding]; other site 476213012757 distal quinone binding site [chemical binding]; other site 476213012758 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 476213012759 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 476213012760 catalytic loop [active] 476213012761 iron binding site [ion binding]; other site 476213012762 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 476213012763 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 476213012764 L-aspartate oxidase; Provisional; Region: PRK06175 476213012765 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 476213012766 poxB regulator PoxA; Provisional; Region: PRK09350 476213012767 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 476213012768 motif 1; other site 476213012769 dimer interface [polypeptide binding]; other site 476213012770 active site 476213012771 motif 2; other site 476213012772 motif 3; other site 476213012773 inner membrane transporter YjeM; Provisional; Region: PRK15238 476213012774 Protein of unknown function (DUF2645); Region: DUF2645; pfam10840 476213012775 putative mechanosensitive channel protein; Provisional; Region: PRK10929 476213012776 Mu-like prophage I protein; Region: Mu-like_Pro; cl19864 476213012777 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 476213012778 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 476213012779 Mechanosensitive ion channel; Region: MS_channel; pfam00924 476213012780 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 476213012781 GTPase RsgA; Reviewed; Region: PRK12288 476213012782 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 476213012783 RNA binding site [nucleotide binding]; other site 476213012784 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 476213012785 GTPase/Zn-binding domain interface [polypeptide binding]; other site 476213012786 GTP/Mg2+ binding site [chemical binding]; other site 476213012787 G4 box; other site 476213012788 G5 box; other site 476213012789 G1 box; other site 476213012790 Switch I region; other site 476213012791 G2 box; other site 476213012792 G3 box; other site 476213012793 Switch II region; other site 476213012794 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 476213012795 catalytic site [active] 476213012796 putative active site [active] 476213012797 putative substrate binding site [chemical binding]; other site 476213012798 dimer interface [polypeptide binding]; other site 476213012799 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 476213012800 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 476213012801 substrate binding pocket [chemical binding]; other site 476213012802 membrane-bound complex binding site; other site 476213012803 hinge residues; other site 476213012804 epoxyqueuosine reductase; Region: TIGR00276 476213012805 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 476213012806 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 476213012807 putative carbohydrate kinase; Provisional; Region: PRK10565 476213012808 Uncharacterized conserved protein [Function unknown]; Region: COG0062 476213012809 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 476213012810 putative substrate binding site [chemical binding]; other site 476213012811 putative ATP binding site [chemical binding]; other site 476213012812 ADP-binding protein; Provisional; Region: PRK10646 476213012813 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 476213012814 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 476213012815 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 476213012816 ATP binding site [chemical binding]; other site 476213012817 Mg2+ binding site [ion binding]; other site 476213012818 G-X-G motif; other site 476213012819 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 476213012820 ATP binding site [chemical binding]; other site 476213012821 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 476213012822 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 476213012823 bacterial Hfq-like; Region: Hfq; cd01716 476213012824 hexamer interface [polypeptide binding]; other site 476213012825 Sm1 motif; other site 476213012826 RNA binding site [nucleotide binding]; other site 476213012827 Sm2 motif; other site 476213012828 GTPase HflX; Provisional; Region: PRK11058 476213012829 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 476213012830 HflX GTPase family; Region: HflX; cd01878 476213012831 G1 box; other site 476213012832 GTP/Mg2+ binding site [chemical binding]; other site 476213012833 Switch I region; other site 476213012834 G2 box; other site 476213012835 G3 box; other site 476213012836 Switch II region; other site 476213012837 G4 box; other site 476213012838 G5 box; other site 476213012839 FtsH protease regulator HflK; Provisional; Region: PRK10930 476213012840 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 476213012841 High frequency of lysogenization K (HflK) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflK; cd03404 476213012842 HflC protein; Region: hflC; TIGR01932 476213012843 High frequency of lysogenization C (HflC) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflC; cd03405 476213012844 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 476213012845 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 476213012846 GDP-binding site [chemical binding]; other site 476213012847 ACT binding site; other site 476213012848 IMP binding site; other site 476213012849 transcriptional repressor NsrR; Provisional; Region: PRK11014 476213012850 Rrf2 family protein; Region: rrf2_super; TIGR00738 476213012851 exoribonuclease R; Provisional; Region: PRK11642 476213012852 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 476213012853 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 476213012854 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 476213012855 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 476213012856 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 476213012857 RNA binding site [nucleotide binding]; other site 476213012858 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 476213012859 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 476213012860 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 476213012861 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3789 476213012862 Ion channel; Region: Ion_trans_2; pfam07885 476213012863 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 476213012864 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 476213012865 Predicted membrane protein [Function unknown]; Region: COG3766 476213012866 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 476213012867 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 476213012868 Predicted integral membrane protein [Function unknown]; Region: COG5463 476213012869 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 476213012870 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 476213012871 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 476213012872 FAD binding site [chemical binding]; other site 476213012873 substrate binding site [chemical binding]; other site 476213012874 catalytic residues [active] 476213012875 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 476213012876 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 476213012877 esterase; Provisional; Region: PRK10566 476213012878 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 476213012879 transcriptional repressor UlaR; Provisional; Region: PRK13509 476213012880 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 476213012881 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 476213012882 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 476213012883 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 476213012884 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 476213012885 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 476213012886 active site 476213012887 phosphorylation site [posttranslational modification] 476213012888 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 476213012889 active site 476213012890 dimer interface [polypeptide binding]; other site 476213012891 magnesium binding site [ion binding]; other site 476213012892 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 476213012893 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 476213012894 AP (apurinic/apyrimidinic) site pocket; other site 476213012895 DNA interaction; other site 476213012896 Metal-binding active site; metal-binding site 476213012897 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 476213012898 intersubunit interface [polypeptide binding]; other site 476213012899 active site 476213012900 Zn2+ binding site [ion binding]; other site 476213012901 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 476213012902 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 476213012903 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 476213012904 dimer interface [polypeptide binding]; other site 476213012905 ssDNA binding site [nucleotide binding]; other site 476213012906 tetramer (dimer of dimers) interface [polypeptide binding]; other site 476213012907 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 476213012908 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 476213012909 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 476213012910 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 476213012911 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 476213012912 EamA-like transporter family; Region: EamA; pfam00892 476213012913 EamA-like transporter family; Region: EamA; pfam00892 476213012914 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 476213012915 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 476213012916 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 476213012917 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 476213012918 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 476213012919 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 476213012920 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 476213012921 DKNYY family; Region: DKNYY; pfam13644 476213012922 DKNYY family; Region: DKNYY; pfam13644 476213012923 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 476213012924 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 476213012925 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 476213012926 Fe binding site [ion binding]; other site 476213012927 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 476213012928 EamA-like transporter family; Region: EamA; pfam00892 476213012929 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 476213012930 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 476213012931 NADP binding site [chemical binding]; other site 476213012932 Predicted transcriptional regulators [Transcription]; Region: COG1733 476213012933 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 476213012934 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 476213012935 active site 476213012936 metal binding site [ion binding]; metal-binding site 476213012937 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 476213012938 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 476213012939 active site 476213012940 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 476213012941 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 476213012942 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 476213012943 Domain of unknown function DUF21; Region: DUF21; pfam01595 476213012944 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 476213012945 Transporter associated domain; Region: CorC_HlyC; smart01091 476213012946 methionine sulfoxide reductase A; Provisional; Region: PRK00058 476213012947 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 476213012948 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 476213012949 Surface antigen; Region: Bac_surface_Ag; pfam01103 476213012950 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 476213012951 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 476213012952 Family of unknown function (DUF490); Region: DUF490; pfam04357 476213012953 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 476213012954 dimerization interface [polypeptide binding]; other site 476213012955 putative active site pocket [active] 476213012956 putative catalytic residue [active] 476213012957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213012958 D-galactonate transporter; Region: 2A0114; TIGR00893 476213012959 putative substrate translocation pore; other site 476213012960 putative metallo-dependent hydrolase; Provisional; Region: PRK12394 476213012961 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 476213012962 active site 476213012963 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 476213012964 dimer interface [polypeptide binding]; other site 476213012965 substrate binding site [chemical binding]; other site 476213012966 metal binding sites [ion binding]; metal-binding site 476213012967 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 476213012968 AMP binding site [chemical binding]; other site 476213012969 metal binding site [ion binding]; metal-binding site 476213012970 active site 476213012971 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 476213012972 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 476213012973 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 476213012974 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 476213012975 hypothetical protein; Provisional; Region: PRK05255 476213012976 peptidase PmbA; Provisional; Region: PRK11040 476213012977 cytochrome b562; Provisional; Region: PRK15058 476213012978 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 476213012979 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; pfam14272 476213012980 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 476213012981 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 476213012982 Domain of unknown function (DUF4310); Region: DUF4310; pfam14187 476213012983 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 476213012984 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 476213012985 active site 476213012986 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 476213012987 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 476213012988 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 476213012989 HTH domain; Region: HTH_11; pfam08279 476213012990 Mga helix-turn-helix domain; Region: Mga; pfam05043 476213012991 PRD domain; Region: PRD; pfam00874 476213012992 PRD domain; Region: PRD; pfam00874 476213012993 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 476213012994 active site 476213012995 P-loop; other site 476213012996 phosphorylation site [posttranslational modification] 476213012997 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 476213012998 active site 476213012999 phosphorylation site [posttranslational modification] 476213013000 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 476213013001 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 476213013002 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 476213013003 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 476213013004 ATP cone domain; Region: ATP-cone; pfam03477 476213013005 Class III ribonucleotide reductase; Region: RNR_III; cd01675 476213013006 effector binding site; other site 476213013007 active site 476213013008 Zn binding site [ion binding]; other site 476213013009 glycine loop; other site 476213013010 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 476213013011 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 476213013012 Ca binding site [ion binding]; other site 476213013013 active site 476213013014 catalytic site [active] 476213013015 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 476213013016 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 476213013017 active site turn [active] 476213013018 phosphorylation site [posttranslational modification] 476213013019 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 476213013020 trehalose repressor; Provisional; Region: treR; PRK09492 476213013021 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 476213013022 DNA binding site [nucleotide binding] 476213013023 domain linker motif; other site 476213013024 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 476213013025 dimerization interface [polypeptide binding]; other site 476213013026 ligand binding site [chemical binding]; other site 476213013027 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 476213013028 homotrimer interaction site [polypeptide binding]; other site 476213013029 putative active site [active] 476213013030 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 476213013031 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 476213013032 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 476213013033 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 476213013034 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 476213013035 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 476213013036 pyrBI operon leader peptide; Provisional; Region: PRK10224 476213013037 Arginine repressor [Transcription]; Region: ArgR; COG1438 476213013038 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 476213013039 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 476213013040 Predicted membrane protein [Function unknown]; Region: COG1288 476213013041 ornithine carbamoyltransferase; Validated; Region: PRK02102 476213013042 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 476213013043 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 476213013044 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 476213013045 putative substrate binding site [chemical binding]; other site 476213013046 nucleotide binding site [chemical binding]; other site 476213013047 nucleotide binding site [chemical binding]; other site 476213013048 homodimer interface [polypeptide binding]; other site 476213013049 arginine deiminase; Provisional; Region: PRK01388 476213013050 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 476213013051 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 476213013052 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 476213013053 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 476213013054 RNase E inhibitor protein; Provisional; Region: PRK11191 476213013055 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 476213013056 active site 476213013057 dinuclear metal binding site [ion binding]; other site 476213013058 dimerization interface [polypeptide binding]; other site 476213013059 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 476213013060 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 476213013061 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 476213013062 Coenzyme A binding pocket [chemical binding]; other site 476213013063 Predicted membrane protein [Function unknown]; Region: COG4269 476213013064 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 476213013065 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 476213013066 active site 476213013067 HIGH motif; other site 476213013068 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 476213013069 KMSKS motif; other site 476213013070 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 476213013071 tRNA binding surface [nucleotide binding]; other site 476213013072 anticodon binding site; other site 476213013073 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 476213013074 DNA polymerase III subunit chi; Validated; Region: PRK05728 476213013075 multifunctional aminopeptidase A; Provisional; Region: PRK00913 476213013076 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 476213013077 interface (dimer of trimers) [polypeptide binding]; other site 476213013078 Substrate-binding/catalytic site; other site 476213013079 Zn-binding sites [ion binding]; other site 476213013080 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 476213013081 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 476213013082 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 476213013083 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 476213013084 DNA binding site [nucleotide binding] 476213013085 domain linker motif; other site 476213013086 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 476213013087 putative dimerization interface [polypeptide binding]; other site 476213013088 putative ligand binding site [chemical binding]; other site 476213013089 fructuronate transporter; Provisional; Region: PRK10034; cl15264 476213013090 GntP family permease; Region: GntP_permease; pfam02447 476213013091 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 476213013092 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 476213013093 NADP binding site [chemical binding]; other site 476213013094 homodimer interface [polypeptide binding]; other site 476213013095 active site 476213013096 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 476213013097 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 476213013098 putative NAD(P) binding site [chemical binding]; other site 476213013099 catalytic Zn binding site [ion binding]; other site 476213013100 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 476213013101 AAA domain; Region: AAA_33; pfam13671 476213013102 ATP-binding site [chemical binding]; other site 476213013103 Gluconate-6-phosphate binding site [chemical binding]; other site 476213013104 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 476213013105 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 476213013106 putative NAD(P) binding site [chemical binding]; other site 476213013107 putative substrate binding site [chemical binding]; other site 476213013108 catalytic Zn binding site [ion binding]; other site 476213013109 structural Zn binding site [ion binding]; other site 476213013110 dimer interface [polypeptide binding]; other site 476213013111 integrase; Provisional; Region: PRK09692 476213013112 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 476213013113 active site 476213013114 Int/Topo IB signature motif; other site 476213013115 Replicase family; Region: Replicase; pfam03090 476213013116 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 476213013117 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl19391 476213013118 DNA methylase; Region: N6_N4_Mtase; cl17433 476213013119 chromosome segregation protein; Provisional; Region: PRK03918 476213013120 P-loop containing region of AAA domain; Region: AAA_29; cl17516 476213013121 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 476213013122 HNH endonuclease; Region: HNH_2; pfam13391 476213013123 hypothetical protein; Provisional; Region: PRK12378 476213013124 hypothetical protein; Provisional; Region: PRK13687 476213013125 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4332 476213013126 Uncharacterized conserved protein [Function unknown]; Region: COG3439 476213013127 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 476213013128 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 476213013129 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 476213013130 DNA-binding site [nucleotide binding]; DNA binding site 476213013131 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 476213013132 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 476213013133 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 476213013134 active site 476213013135 HIGH motif; other site 476213013136 dimer interface [polypeptide binding]; other site 476213013137 KMSKS motif; other site 476213013138 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 476213013139 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 476213013140 cell density-dependent motility repressor; Provisional; Region: PRK10082 476213013141 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 476213013142 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 476213013143 dimerization interface [polypeptide binding]; other site 476213013144 hypothetical protein; Provisional; Region: PRK10519 476213013145 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 476213013146 Nucleoside recognition; Region: Gate; pfam07670 476213013147 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213013148 Major Facilitator Superfamily; Region: MFS_1; pfam07690 476213013149 putative substrate translocation pore; other site 476213013150 Predicted membrane protein [Function unknown]; Region: COG2733 476213013151 Protein of unknown function (DUF445); Region: DUF445; pfam04286 476213013152 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 476213013153 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 476213013154 putative substrate translocation pore; other site 476213013155 putative transposase; Provisional; Region: PRK09857 476213013156 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 476213013157 Integrase core domain; Region: rve; pfam00665 476213013158 Integrase core domain; Region: rve_3; pfam13683 476213013159 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 476213013160 Helix-turn-helix domain; Region: HTH_28; pfam13518 476213013161 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 476213013162 endoribonuclease SymE; Provisional; Region: PRK13605 476213013163 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 476213013164 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 476213013165 K cyclin, C terminal; Region: K-cyclin_vir_C; pfam09080 476213013166 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 476213013167 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213013168 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 476213013169 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 476213013170 P-loop, Walker A motif; other site 476213013171 Base recognition motif; other site 476213013172 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 476213013173 Uncharacterized small protein [Function unknown]; Region: COG2879 476213013174 carbon starvation protein A; Provisional; Region: PRK15015 476213013175 Carbon starvation protein CstA; Region: CstA; pfam02554 476213013176 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 476213013177 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 476213013178 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 476213013179 dimer interface [polypeptide binding]; other site 476213013180 ligand binding site [chemical binding]; other site 476213013181 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 476213013182 dimerization interface [polypeptide binding]; other site 476213013183 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 476213013184 dimer interface [polypeptide binding]; other site 476213013185 putative CheW interface [polypeptide binding]; other site 476213013186 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 476213013187 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 476213013188 Walker A motif; other site 476213013189 ATP binding site [chemical binding]; other site 476213013190 Walker B motif; other site 476213013191 arginine finger; other site 476213013192 Transcriptional antiterminator [Transcription]; Region: COG3933 476213013193 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 476213013194 active pocket/dimerization site; other site 476213013195 active site 476213013196 phosphorylation site [posttranslational modification] 476213013197 PRD domain; Region: PRD; pfam00874 476213013198 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 476213013199 active pocket/dimerization site; other site 476213013200 active site 476213013201 phosphorylation site [posttranslational modification] 476213013202 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 476213013203 active site 476213013204 phosphorylation site [posttranslational modification] 476213013205 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 476213013206 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 476213013207 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 476213013208 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 476213013209 dimer interface [polypeptide binding]; other site 476213013210 active site 476213013211 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 476213013212 dimer interface [polypeptide binding]; other site 476213013213 active site 476213013214 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 476213013215 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 476213013216 putative active site [active] 476213013217 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 476213013218 phosphoglycerol transferase I; Provisional; Region: PRK03776 476213013219 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 476213013220 hypothetical protein; Provisional; Region: PRK11667 476213013221 DNA replication protein DnaC; Validated; Region: PRK07952 476213013222 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 476213013223 Walker A motif; other site 476213013224 ATP binding site [chemical binding]; other site 476213013225 Walker B motif; other site 476213013226 primosomal protein DnaI; Provisional; Region: PRK02854 476213013227 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 476213013228 Uncharacterized conserved protein [Function unknown]; Region: COG2966 476213013229 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 476213013230 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 476213013231 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 476213013232 DNA binding residues [nucleotide binding] 476213013233 dimerization interface [polypeptide binding]; other site 476213013234 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 476213013235 putative deacylase active site [active] 476213013236 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 476213013237 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 476213013238 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 476213013239 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 476213013240 metal binding site [ion binding]; metal-binding site 476213013241 active site 476213013242 I-site; other site 476213013243 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 476213013244 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 476213013245 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 476213013246 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 476213013247 S-adenosylmethionine binding site [chemical binding]; other site 476213013248 DNA polymerase III subunit psi; Validated; Region: PRK06856 476213013249 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 476213013250 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 476213013251 Coenzyme A binding pocket [chemical binding]; other site 476213013252 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 476213013253 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 476213013254 motif II; other site 476213013255 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 476213013256 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 476213013257 G1 box; other site 476213013258 putative GEF interaction site [polypeptide binding]; other site 476213013259 GTP/Mg2+ binding site [chemical binding]; other site 476213013260 Switch I region; other site 476213013261 G2 box; other site 476213013262 G3 box; other site 476213013263 Switch II region; other site 476213013264 G4 box; other site 476213013265 G5 box; other site 476213013266 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 476213013267 Elongation Factor G, domain II; Region: EFG_II; pfam14492 476213013268 periplasmic protein; Provisional; Region: PRK10568 476213013269 BON domain; Region: BON; pfam04972 476213013270 BON domain; Region: BON; pfam04972 476213013271 Small integral membrane protein [Function unknown]; Region: COG5487 476213013272 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 476213013273 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 476213013274 active site 476213013275 nucleophile elbow; other site 476213013276 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 476213013277 active site 476213013278 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 476213013279 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 476213013280 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 476213013281 FeS/SAM binding site; other site 476213013282 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 476213013283 hypothetical protein; Provisional; Region: PRK10977 476213013284 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 476213013285 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 476213013286 intersubunit interface [polypeptide binding]; other site 476213013287 active site 476213013288 catalytic residue [active] 476213013289 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 476213013290 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 476213013291 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 476213013292 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 476213013293 phosphopentomutase; Provisional; Region: PRK05362 476213013294 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 476213013295 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 476213013296 HipA-like N-terminal domain; Region: HipA_N; pfam07805 476213013297 HipA-like C-terminal domain; Region: HipA_C; pfam07804 476213013298 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 476213013299 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 476213013300 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 476213013301 hypothetical protein; Provisional; Region: PRK11246 476213013302 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 476213013303 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 476213013304 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 476213013305 motif II; other site 476213013306 DNA repair protein RadA; Region: sms; TIGR00416 476213013307 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 476213013308 Walker A motif/ATP binding site; other site 476213013309 ATP binding site [chemical binding]; other site 476213013310 Walker B motif; other site 476213013311 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 476213013312 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 476213013313 non-specific DNA binding site [nucleotide binding]; other site 476213013314 salt bridge; other site 476213013315 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 476213013316 sequence-specific DNA binding site [nucleotide binding]; other site 476213013317 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 476213013318 active site 476213013319 (T/H)XGH motif; other site 476213013320 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 476213013321 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 476213013322 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 476213013323 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 476213013324 ABC transporter; Region: ABC_tran_2; pfam12848 476213013325 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 476213013326 lytic murein transglycosylase; Provisional; Region: PRK11619 476213013327 Soluble lytic murein transglycosylase L domain; Region: SLT_L; pfam14718 476213013328 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 476213013329 N-acetyl-D-glucosamine binding site [chemical binding]; other site 476213013330 catalytic residue [active] 476213013331 Trp operon repressor; Provisional; Region: PRK01381 476213013332 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 476213013333 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 476213013334 catalytic core [active] 476213013335 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 476213013336 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213013337 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 476213013338 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 476213013339 hypothetical protein; Provisional; Region: PRK10756 476213013340 DNA-binding response regulator CreB; Provisional; Region: PRK11083 476213013341 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 476213013342 active site 476213013343 phosphorylation site [posttranslational modification] 476213013344 intermolecular recognition site; other site 476213013345 dimerization interface [polypeptide binding]; other site 476213013346 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 476213013347 DNA binding site [nucleotide binding] 476213013348 sensory histidine kinase CreC; Provisional; Region: PRK11100 476213013349 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 476213013350 dimerization interface [polypeptide binding]; other site 476213013351 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 476213013352 dimer interface [polypeptide binding]; other site 476213013353 phosphorylation site [posttranslational modification] 476213013354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 476213013355 ATP binding site [chemical binding]; other site 476213013356 Mg2+ binding site [ion binding]; other site 476213013357 G-X-G motif; other site 476213013358 putative major fimbrial protein SthE; Provisional; Region: PRK15292 476213013359 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 476213013360 putative fimbrial protein SthD; Provisional; Region: PRK15293 476213013361 putative fimbrial outer membrane usher protein SthC; Provisional; Region: PRK15294 476213013362 PapC N-terminal domain; Region: PapC_N; pfam13954 476213013363 Outer membrane usher protein; Region: Usher; pfam00577 476213013364 PapC C-terminal domain; Region: PapC_C; pfam13953 476213013365 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 476213013366 Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345 476213013367 Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753 476213013368 putative fimbrial protein SthA; Provisional; Region: PRK15296 476213013369 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 476213013370 two-component response regulator; Provisional; Region: PRK11173 476213013371 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 476213013372 active site 476213013373 phosphorylation site [posttranslational modification] 476213013374 intermolecular recognition site; other site 476213013375 dimerization interface [polypeptide binding]; other site 476213013376 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 476213013377 DNA binding site [nucleotide binding] 476213013378 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 476213013379 putative RNA methyltransferase; Provisional; Region: PRK10433