-- dump date   	20140620_054505
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
439843000001	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
439843000002	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
439843000003	Catalytic site [active]
439843000004	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
439843000005	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
439843000006	active site
439843000007	DNA binding site [nucleotide binding]
439843000008	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
439843000009	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
439843000010	plasmid-partitioning protein; Provisional; Region: PRK13698
439843000011	ParB-like nuclease domain; Region: ParB; smart00470
439843000012	plasmid-partitioning protein SopA; Provisional; Region: PRK13705
439843000013	MerR family regulatory protein; Region: MerR; pfam00376
439843000014	DNA binding residues [nucleotide binding]
439843000015	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
439843000016	P-loop; other site
439843000017	Magnesium ion binding site [ion binding]; other site
439843000018	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
439843000019	Magnesium ion binding site [ion binding]; other site
439843000020	Initiator Replication protein; Region: Rep_3; pfam01051
439843000021	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
439843000022	transcriptional regulator MirA; Provisional; Region: PRK15043
439843000023	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
439843000024	DNA binding residues [nucleotide binding]
439843000025	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
439843000026	active site
439843000027	homotetramer interface [polypeptide binding]; other site
439843000028	Protein of unknown function (DUF523); Region: DUF523; pfam04463
439843000029	Uncharacterized conserved protein [Function unknown]; Region: COG3272
439843000030	Protein of unknown function (DUF1722); Region: DUF1722; cl01284
439843000031	Predicted ATPase [General function prediction only]; Region: COG4637
439843000032	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439843000033	Walker A/P-loop; other site
439843000034	ATP binding site [chemical binding]; other site
439843000035	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439843000036	ABC transporter signature motif; other site
439843000037	Walker B; other site
439843000038	D-loop; other site
439843000039	H-loop/switch region; other site
439843000040	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
439843000041	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
439843000042	Integrase core domain; Region: rve; pfam00665
439843000043	type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448
439843000044	bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235
439843000045	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
439843000046	transposase/IS protein; Provisional; Region: PRK09183
439843000047	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439843000048	Walker A motif; other site
439843000049	ATP binding site [chemical binding]; other site
439843000050	Walker B motif; other site
439843000051	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
439843000052	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
439843000053	putative DNA binding site [nucleotide binding]; other site
439843000054	putative Zn2+ binding site [ion binding]; other site
439843000055	Integrase core domain; Region: rve; pfam00665
439843000056	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
439843000057	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
439843000058	Domain of unknown function (DUF2357); Region: DUF2357; pfam09823
439843000059	Protein of unknown function (DUF524); Region: DUF524; pfam04411
439843000060	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
439843000061	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
439843000062	HTH-like domain; Region: HTH_21; pfam13276
439843000063	Integrase core domain; Region: rve; pfam00665
439843000064	Integrase core domain; Region: rve_3; pfam13683
439843000065	Insertion sequence IS1222 ribosomal frameshifting element
439843000066	Transposase; Region: HTH_Tnp_1; pfam01527
439843000067	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
439843000068	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
439843000069	active site
439843000070	DNA binding site [nucleotide binding]
439843000071	Int/Topo IB signature motif; other site
439843000072	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
439843000073	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
439843000074	EamA-like transporter family; Region: EamA; pfam00892
439843000075	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
439843000076	EamA-like transporter family; Region: EamA; pfam00892
439843000077	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843000078	Major Facilitator Superfamily; Region: MFS_1; pfam07690
439843000079	putative substrate translocation pore; other site
439843000080	tetracycline repressor protein TetR; Provisional; Region: PRK13756
439843000081	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
439843000082	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
439843000083	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
439843000084	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
439843000085	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
439843000086	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
439843000087	multiple promoter invertase; Provisional; Region: mpi; PRK13413
439843000088	catalytic residues [active]
439843000089	catalytic nucleophile [active]
439843000090	Presynaptic Site I dimer interface [polypeptide binding]; other site
439843000091	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
439843000092	Synaptic Flat tetramer interface [polypeptide binding]; other site
439843000093	Synaptic Site I dimer interface [polypeptide binding]; other site
439843000094	DNA binding site [nucleotide binding]
439843000095	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
439843000096	DNA-binding interface [nucleotide binding]; DNA binding site
439843000097	valyl-tRNA synthetase-like protein; Provisional; Region: PTZ00419
439843000098	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
439843000099	DNA binding site [nucleotide binding]
439843000100	active site
439843000101	Int/Topo IB signature motif; other site
439843000102	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
439843000103	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
439843000104	Integrase core domain; Region: rve; pfam00665
439843000105	Integrase core domain; Region: rve; pfam00665
439843000106	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
439843000107	putative mercury resistance protein; Provisional; Region: PRK13747
439843000108	transcriptional regulator MerD; Provisional; Region: PRK13749
439843000109	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
439843000110	DNA binding residues [nucleotide binding]
439843000111	putative mercuric reductase; Provisional; Region: PRK13748
439843000112	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
439843000113	metal-binding site [ion binding]
439843000114	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
439843000115	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
439843000116	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
439843000117	beta-lactamase TEM; Provisional; Region: PRK15442
439843000118	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
439843000119	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
439843000120	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
439843000121	Integrase core domain; Region: rve; pfam00665
439843000122	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
439843000123	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
439843000124	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
439843000125	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
439843000126	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
439843000127	multiple promoter invertase; Provisional; Region: mpi; PRK13413
439843000128	catalytic residues [active]
439843000129	catalytic nucleophile [active]
439843000130	Presynaptic Site I dimer interface [polypeptide binding]; other site
439843000131	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
439843000132	Synaptic Flat tetramer interface [polypeptide binding]; other site
439843000133	Synaptic Site I dimer interface [polypeptide binding]; other site
439843000134	DNA binding site [nucleotide binding]
439843000135	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
439843000136	DNA-binding interface [nucleotide binding]; DNA binding site
439843000137	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
439843000138	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
439843000139	Integrase core domain; Region: rve; pfam00665
439843000140	H+ Antiporter protein; Region: 2A0121; TIGR00900
439843000141	short chain dehydrogenase; Provisional; Region: PRK08263
439843000142	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
439843000143	NADP binding site [chemical binding]; other site
439843000144	active site
439843000145	steroid binding site; other site
439843000146	dihydropteroate synthase; Region: DHPS; TIGR01496
439843000147	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
439843000148	substrate binding pocket [chemical binding]; other site
439843000149	dimer interface [polypeptide binding]; other site
439843000150	inhibitor binding site; inhibition site
439843000151	Transposase, Mutator family; Region: Transposase_mut; pfam00872
439843000152	MULE transposase domain; Region: MULE; pfam10551
439843000153	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
439843000154	aminoglycoside resistance protein; Provisional; Region: PRK13746
439843000155	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
439843000156	active site
439843000157	NTP binding site [chemical binding]; other site
439843000158	metal binding triad [ion binding]; metal-binding site
439843000159	antibiotic binding site [chemical binding]; other site
439843000160	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
439843000161	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
439843000162	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843000163	putative substrate translocation pore; other site
439843000164	aminoglycoside resistance protein; Provisional; Region: PRK13746
439843000165	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
439843000166	active site
439843000167	NTP binding site [chemical binding]; other site
439843000168	metal binding triad [ion binding]; metal-binding site
439843000169	antibiotic binding site [chemical binding]; other site
439843000170	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
439843000171	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
439843000172	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
439843000173	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
439843000174	TAP-like protein; Region: Abhydrolase_4; pfam08386
439843000175	integrase/recombinase; Provisional; Region: PRK15417
439843000176	IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193
439843000177	Int/Topo IB signature motif; other site
439843000178	valyl-tRNA synthetase-like protein; Provisional; Region: PTZ00419
439843000179	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
439843000180	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
439843000181	Integrase core domain; Region: rve; pfam00665
439843000182	DDE domain; Region: DDE_Tnp_IS240; pfam13610
439843000183	Integrase core domain; Region: rve; pfam00665
439843000184	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
439843000185	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
439843000186	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
439843000187	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
439843000188	Integrase core domain; Region: rve; pfam00665
439843000189	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
439843000190	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
439843000191	Integrase core domain; Region: rve; pfam00665
439843000192	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
439843000193	putative mercury transport protein MerC; Provisional; Region: PRK13755
439843000194	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
439843000195	metal-binding site [ion binding]
439843000196	putative mercuric transport protein; Provisional; Region: PRK13751
439843000197	putative transcriptional regulator MerR; Provisional; Region: PRK13752
439843000198	Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783
439843000199	DNA binding residues [nucleotide binding]
439843000200	dimer interface [polypeptide binding]; other site
439843000201	mercury binding site [ion binding]; other site
439843000202	Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; pfam04655
439843000203	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
439843000204	Phosphotransferase enzyme family; Region: APH; pfam01636
439843000205	active site
439843000206	ATP binding site [chemical binding]; other site
439843000207	antibiotic binding site [chemical binding]; other site
439843000208	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
439843000209	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
439843000210	Domain of unknown function (DUF4102); Region: DUF4102; pfam13356
439843000211	dihydropteroate synthase; Region: DHPS; TIGR01496
439843000212	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
439843000213	substrate binding pocket [chemical binding]; other site
439843000214	dimer interface [polypeptide binding]; other site
439843000215	inhibitor binding site; inhibition site
439843000216	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
439843000217	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
439843000218	Putative transposase; Region: Y2_Tnp; pfam04986
439843000219	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
439843000220	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
439843000221	catalytic residues [active]
439843000222	catalytic nucleophile [active]
439843000223	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
439843000224	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
439843000225	Integrase core domain; Region: rve; pfam00665
439843000226	Chloramphenicol acetyltransferase; Region: CAT; pfam00302
439843000227	Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845
439843000228	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
439843000229	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
439843000230	Integrase core domain; Region: rve; pfam00665
439843000231	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
439843000232	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439843000233	dimer interface [polypeptide binding]; other site
439843000234	phosphorylation site [posttranslational modification]
439843000235	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439843000236	ATP binding site [chemical binding]; other site
439843000237	Mg2+ binding site [ion binding]; other site
439843000238	G-X-G motif; other site
439843000239	Response regulator receiver domain; Region: Response_reg; pfam00072
439843000240	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843000241	active site
439843000242	phosphorylation site [posttranslational modification]
439843000243	intermolecular recognition site; other site
439843000244	dimerization interface [polypeptide binding]; other site
439843000245	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
439843000246	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
439843000247	BetR domain; Region: BetR; pfam08667
439843000248	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
439843000249	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843000250	active site
439843000251	phosphorylation site [posttranslational modification]
439843000252	intermolecular recognition site; other site
439843000253	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
439843000254	N-acetyl-D-glucosamine binding site [chemical binding]; other site
439843000255	catalytic residue [active]
439843000256	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
439843000257	type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929
439843000258	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
439843000259	P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791
439843000260	Type IV secretion system proteins; Region: T4SS; pfam07996
439843000261	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
439843000262	VirB8 protein; Region: VirB8; pfam04335
439843000263	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
439843000264	VirB7 interaction site; other site
439843000265	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
439843000266	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
439843000267	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
439843000268	Walker A motif; other site
439843000269	hexamer interface [polypeptide binding]; other site
439843000270	ATP binding site [chemical binding]; other site
439843000271	Walker B motif; other site
439843000272	Cag pathogenicity island protein Cag12; Region: Cag12; pfam13117
439843000273	conjugal transfer protein TrbM; Provisional; Region: PRK13893
439843000274	DNA topoisomerase III; Provisional; Region: PRK07726
439843000275	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
439843000276	active site
439843000277	putative interdomain interaction site [polypeptide binding]; other site
439843000278	putative metal-binding site [ion binding]; other site
439843000279	putative nucleotide binding site [chemical binding]; other site
439843000280	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986
439843000281	domain I; other site
439843000282	DNA binding groove [nucleotide binding]
439843000283	phosphate binding site [ion binding]; other site
439843000284	domain II; other site
439843000285	domain III; other site
439843000286	nucleotide binding site [chemical binding]; other site
439843000287	catalytic site [active]
439843000288	domain IV; other site
439843000289	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
439843000290	DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328
439843000291	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
439843000292	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
439843000293	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
439843000294	Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170
439843000295	PLD-like domain; Region: PLDc_2; pfam13091
439843000296	putative active site [active]
439843000297	catalytic site [active]
439843000298	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
439843000299	Protein of unknown function, DUF462; Region: DUF462; cl01190
439843000300	Replicase family; Region: Replicase; pfam03090
439843000301	Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708
439843000302	Homeodomain-like domain; Region: HTH_23; pfam13384
439843000303	MobA/MobL family; Region: MobA_MobL; pfam03389
439843000304	Conjugal transfer protein TraD; Region: TraD; pfam06412
439843000305	Threonine operon leader
439843000306	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
439843000307	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
439843000308	putative catalytic residues [active]
439843000309	putative nucleotide binding site [chemical binding]; other site
439843000310	putative aspartate binding site [chemical binding]; other site
439843000311	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
439843000312	dimer interface [polypeptide binding]; other site
439843000313	putative threonine allosteric regulatory site; other site
439843000314	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
439843000315	putative threonine allosteric regulatory site; other site
439843000316	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
439843000317	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
439843000318	homoserine kinase; Provisional; Region: PRK01212
439843000319	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
439843000320	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
439843000321	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
439843000322	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843000323	catalytic residue [active]
439843000324	hypothetical protein; Validated; Region: PRK02101
439843000325	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
439843000326	Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235
439843000327	transaldolase-like protein; Provisional; Region: PTZ00411
439843000328	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
439843000329	active site
439843000330	dimer interface [polypeptide binding]; other site
439843000331	catalytic residue [active]
439843000332	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
439843000333	MPT binding site; other site
439843000334	trimer interface [polypeptide binding]; other site
439843000335	hypothetical protein; Provisional; Region: PRK10659
439843000336	hypothetical protein; Provisional; Region: PRK10236
439843000337	Domain of unknown function (DUF3944); Region: DUF3944; pfam13099
439843000338	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735
439843000339	Protein of unknown function (DUF2541); Region: DUF2541; cl08090
439843000340	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
439843000341	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
439843000342	nucleotide binding site [chemical binding]; other site
439843000343	chaperone protein DnaJ; Provisional; Region: PRK10767
439843000344	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
439843000345	HSP70 interaction site [polypeptide binding]; other site
439843000346	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
439843000347	substrate binding site [polypeptide binding]; other site
439843000348	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
439843000349	Zn binding sites [ion binding]; other site
439843000350	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
439843000351	dimer interface [polypeptide binding]; other site
439843000352	Transcriptional regulator [Transcription]; Region: LysR; COG0583
439843000353	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843000354	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
439843000355	substrate binding pocket [chemical binding]; other site
439843000356	dimerization interface [polypeptide binding]; other site
439843000357	Lysozyme family protein [General function prediction only]; Region: zliS; COG3926
439843000358	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
439843000359	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
439843000360	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
439843000361	Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325
439843000362	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
439843000363	active site
439843000364	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
439843000365	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
439843000366	aromatic chitin/cellulose binding site residues [chemical binding]; other site
439843000367	Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048
439843000368	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
439843000369	Helix-turn-helix domain; Region: HTH_36; pfam13730
439843000370	fimbrial protein BcfA; Provisional; Region: PRK15187
439843000371	fimbrial chaperone protein BcfB; Provisional; Region: PRK15188
439843000372	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
439843000373	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
439843000374	outer membrane usher protein; Provisional; Region: PRK15193
439843000375	PapC N-terminal domain; Region: PapC_N; pfam13954
439843000376	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
439843000377	PapC C-terminal domain; Region: PapC_C; pfam13953
439843000378	fimbrial protein BcfD; Provisional; Region: PRK15189
439843000379	fimbrial protein BcfE; Provisional; Region: PRK15190
439843000380	fimbrial protein BcfF; Provisional; Region: PRK15191
439843000381	fimbrial chaperone BcfG; Provisional; Region: PRK15192
439843000382	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
439843000383	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
439843000384	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
439843000385	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
439843000386	catalytic residues [active]
439843000387	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
439843000388	Transcriptional regulator [Transcription]; Region: LysR; COG0583
439843000389	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843000390	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
439843000391	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
439843000392	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
439843000393	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
439843000394	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
439843000395	active site
439843000396	metal binding site [ion binding]; metal-binding site
439843000397	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
439843000398	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502
439843000399	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
439843000400	Sulfatase; Region: Sulfatase; pfam00884
439843000401	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
439843000402	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439843000403	FeS/SAM binding site; other site
439843000404	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
439843000405	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
439843000406	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
439843000407	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561
439843000408	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
439843000409	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843000410	The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429
439843000411	putative dimerization interface [polypeptide binding]; other site
439843000412	putative alpha-glucosidase; Provisional; Region: PRK10658
439843000413	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
439843000414	XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591
439843000415	putative active site [active]
439843000416	putative catalytic site [active]
439843000417	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
439843000418	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
439843000419	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
439843000420	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
439843000421	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
439843000422	active site
439843000423	Riboflavin kinase; Region: Flavokinase; smart00904
439843000424	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
439843000425	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
439843000426	active site
439843000427	HIGH motif; other site
439843000428	nucleotide binding site [chemical binding]; other site
439843000429	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
439843000430	active site
439843000431	KMSKS motif; other site
439843000432	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
439843000433	tRNA binding surface [nucleotide binding]; other site
439843000434	anticodon binding site; other site
439843000435	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
439843000436	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
439843000437	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
439843000438	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
439843000439	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
439843000440	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
439843000441	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
439843000442	active site
439843000443	tetramer interface [polypeptide binding]; other site
439843000444	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
439843000445	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843000446	active site
439843000447	phosphorylation site [posttranslational modification]
439843000448	intermolecular recognition site; other site
439843000449	dimerization interface [polypeptide binding]; other site
439843000450	Transcriptional regulator; Region: CitT; pfam12431
439843000451	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
439843000452	PAS domain; Region: PAS; smart00091
439843000453	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439843000454	ATP binding site [chemical binding]; other site
439843000455	Mg2+ binding site [ion binding]; other site
439843000456	G-X-G motif; other site
439843000457	oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476
439843000458	oxaloacetate decarboxylase; Provisional; Region: PRK14040
439843000459	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
439843000460	active site
439843000461	catalytic residues [active]
439843000462	metal binding site [ion binding]; metal-binding site
439843000463	homodimer binding site [polypeptide binding]; other site
439843000464	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
439843000465	carboxyltransferase (CT) interaction site; other site
439843000466	biotinylation site [posttranslational modification]; other site
439843000467	oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919
439843000468	Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493
439843000469	Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053
439843000470	Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169
439843000471	putative active site [active]
439843000472	(T/H)XGH motif; other site
439843000473	Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052
439843000474	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
439843000475	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
439843000476	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
439843000477	Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697
439843000478	triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125
439843000479	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
439843000480	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
439843000481	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
439843000482	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
439843000483	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
439843000484	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
439843000485	catalytic site [active]
439843000486	subunit interface [polypeptide binding]; other site
439843000487	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
439843000488	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
439843000489	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
439843000490	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
439843000491	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
439843000492	ATP-grasp domain; Region: ATP-grasp_4; cl17255
439843000493	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
439843000494	IMP binding site; other site
439843000495	dimer interface [polypeptide binding]; other site
439843000496	interdomain contacts; other site
439843000497	partial ornithine binding site; other site
439843000498	DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476
439843000499	carnitine operon protein CaiE; Provisional; Region: PRK13627
439843000500	paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745
439843000501	putative trimer interface [polypeptide binding]; other site
439843000502	putative metal binding site [ion binding]; other site
439843000503	carnitinyl-CoA dehydratase; Provisional; Region: PRK03580
439843000504	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
439843000505	substrate binding site [chemical binding]; other site
439843000506	oxyanion hole (OAH) forming residues; other site
439843000507	trimer interface [polypeptide binding]; other site
439843000508	putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008
439843000509	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934
439843000510	acyl-activating enzyme (AAE) consensus motif; other site
439843000511	putative AMP binding site [chemical binding]; other site
439843000512	putative active site [active]
439843000513	putative CoA binding site [chemical binding]; other site
439843000514	crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525
439843000515	CoA-transferase family III; Region: CoA_transf_3; pfam02515
439843000516	crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354
439843000517	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
439843000518	active site
439843000519	L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356
439843000520	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
439843000521	Ligand binding site [chemical binding]; other site
439843000522	Electron transfer flavoprotein domain; Region: ETF; pfam01012
439843000523	putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363
439843000524	Electron transfer flavoprotein domain; Region: ETF; smart00893
439843000525	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
439843000526	putative oxidoreductase FixC; Provisional; Region: PRK10157
439843000527	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
439843000528	ferredoxin-like protein FixX; Provisional; Region: PRK15449
439843000529	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843000530	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
439843000531	putative substrate translocation pore; other site
439843000532	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
439843000533	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
439843000534	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
439843000535	Sulfatase; Region: Sulfatase; cl17466
439843000536	Sulfatase; Region: Sulfatase; cl17466
439843000537	Sulfatase; Region: Sulfatase; cl17466
439843000538	glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871
439843000539	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
439843000540	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
439843000541	TrkA-N domain; Region: TrkA_N; pfam02254
439843000542	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
439843000543	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
439843000544	folate binding site [chemical binding]; other site
439843000545	NADP+ binding site [chemical binding]; other site
439843000546	bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668
439843000547	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
439843000548	active site
439843000549	metal binding site [ion binding]; metal-binding site
439843000550	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
439843000551	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
439843000552	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
439843000553	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
439843000554	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
439843000555	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
439843000556	SurA N-terminal domain; Region: SurA_N; pfam09312
439843000557	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
439843000558	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
439843000559	LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761
439843000560	OstA-like protein; Region: OstA; pfam03968
439843000561	Organic solvent tolerance protein; Region: OstA_C; pfam04453
439843000562	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
439843000563	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
439843000564	putative metal binding site [ion binding]; other site
439843000565	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
439843000566	HSP70 interaction site [polypeptide binding]; other site
439843000567	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
439843000568	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
439843000569	active site
439843000570	ATP-dependent helicase HepA; Validated; Region: PRK04914
439843000571	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
439843000572	ATP binding site [chemical binding]; other site
439843000573	putative Mg++ binding site [ion binding]; other site
439843000574	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
439843000575	nucleotide binding region [chemical binding]; other site
439843000576	ATP-binding site [chemical binding]; other site
439843000577	DNA polymerase II; Reviewed; Region: PRK05762
439843000578	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
439843000579	active site
439843000580	catalytic site [active]
439843000581	substrate binding site [chemical binding]; other site
439843000582	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
439843000583	active site
439843000584	metal-binding site
439843000585	Uncharacterized conserved protein [Function unknown]; Region: COG1434
439843000586	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
439843000587	putative active site [active]
439843000588	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
439843000589	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
439843000590	intersubunit interface [polypeptide binding]; other site
439843000591	active site
439843000592	Zn2+ binding site [ion binding]; other site
439843000593	L-arabinose isomerase; Provisional; Region: PRK02929
439843000594	L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557
439843000595	putative hexamer (dimer of trimers) interface [polypeptide binding]; other site
439843000596	trimer interface [polypeptide binding]; other site
439843000597	putative substrate binding site [chemical binding]; other site
439843000598	putative metal binding site [ion binding]; other site
439843000599	ribulokinase; Provisional; Region: PRK04123
439843000600	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
439843000601	N- and C-terminal domain interface [polypeptide binding]; other site
439843000602	active site
439843000603	MgATP binding site [chemical binding]; other site
439843000604	catalytic site [active]
439843000605	metal binding site [ion binding]; metal-binding site
439843000606	carbohydrate binding site [chemical binding]; other site
439843000607	homodimer interface [polypeptide binding]; other site
439843000608	DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572
439843000609	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
439843000610	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439843000611	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439843000612	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
439843000613	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
439843000614	thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771
439843000615	ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298
439843000616	Walker A/P-loop; other site
439843000617	ATP binding site [chemical binding]; other site
439843000618	Q-loop/lid; other site
439843000619	ABC transporter signature motif; other site
439843000620	Walker B; other site
439843000621	D-loop; other site
439843000622	H-loop/switch region; other site
439843000623	thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433
439843000624	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843000625	dimer interface [polypeptide binding]; other site
439843000626	conserved gate region; other site
439843000627	putative PBP binding loops; other site
439843000628	ABC-ATPase subunit interface; other site
439843000629	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843000630	dimer interface [polypeptide binding]; other site
439843000631	conserved gate region; other site
439843000632	putative PBP binding loops; other site
439843000633	ABC-ATPase subunit interface; other site
439843000634	thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205
439843000635	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
439843000636	transcriptional regulator SgrR; Provisional; Region: PRK13626
439843000637	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
439843000638	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
439843000639	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
439843000640	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
439843000641	substrate binding site [chemical binding]; other site
439843000642	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
439843000643	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
439843000644	substrate binding site [chemical binding]; other site
439843000645	ligand binding site [chemical binding]; other site
439843000646	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
439843000647	tartrate dehydrogenase; Region: TTC; TIGR02089
439843000648	2-isopropylmalate synthase; Validated; Region: PRK00915
439843000649	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
439843000650	active site
439843000651	catalytic residues [active]
439843000652	metal binding site [ion binding]; metal-binding site
439843000653	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
439843000654	Leucine operon leader
439843000655	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
439843000656	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843000657	The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466
439843000658	putative substrate binding pocket [chemical binding]; other site
439843000659	putative dimerization interface [polypeptide binding]; other site
439843000660	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979
439843000661	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
439843000662	PYR/PP interface [polypeptide binding]; other site
439843000663	dimer interface [polypeptide binding]; other site
439843000664	TPP binding site [chemical binding]; other site
439843000665	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
439843000666	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
439843000667	TPP-binding site [chemical binding]; other site
439843000668	dimer interface [polypeptide binding]; other site
439843000669	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
439843000670	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
439843000671	putative valine binding site [chemical binding]; other site
439843000672	dimer interface [polypeptide binding]; other site
439843000673	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
439843000674	DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303
439843000675	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
439843000676	DNA binding site [nucleotide binding]
439843000677	domain linker motif; other site
439843000678	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
439843000679	dimerization interface [polypeptide binding]; other site
439843000680	ligand binding site [chemical binding]; other site
439843000681	mraZ protein; Region: TIGR00242
439843000682	MraZ protein; Region: MraZ; pfam02381
439843000683	MraZ protein; Region: MraZ; pfam02381
439843000684	16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006
439843000685	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
439843000686	cell division protein FtsL; Provisional; Region: PRK10772
439843000687	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
439843000688	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
439843000689	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
439843000690	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
439843000691	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
439843000692	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
439843000693	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
439843000694	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773
439843000695	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
439843000696	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
439843000697	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
439843000698	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
439843000699	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
439843000700	Mg++ binding site [ion binding]; other site
439843000701	putative catalytic motif [active]
439843000702	putative substrate binding site [chemical binding]; other site
439843000703	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806
439843000704	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
439843000705	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
439843000706	cell division protein FtsW; Provisional; Region: PRK10774
439843000707	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
439843000708	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
439843000709	active site
439843000710	homodimer interface [polypeptide binding]; other site
439843000711	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
439843000712	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
439843000713	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
439843000714	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
439843000715	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
439843000716	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
439843000717	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
439843000718	cell division protein FtsQ; Provisional; Region: PRK10775
439843000719	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
439843000720	Cell division protein FtsQ; Region: FtsQ; pfam03799
439843000721	cell division protein FtsA; Reviewed; Region: ftsA; PRK09472
439843000722	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
439843000723	Cell division protein FtsA; Region: FtsA; pfam14450
439843000724	cell division protein FtsZ; Validated; Region: PRK09330
439843000725	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
439843000726	nucleotide binding site [chemical binding]; other site
439843000727	SulA interaction site; other site
439843000728	cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483
439843000729	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
439843000730	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
439843000731	SecA regulator SecM; Provisional; Region: PRK02943
439843000732	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
439843000733	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
439843000734	SEC-C motif; Region: SEC-C; pfam02810
439843000735	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
439843000736	active site
439843000737	8-oxo-dGMP binding site [chemical binding]; other site
439843000738	nudix motif; other site
439843000739	metal binding site [ion binding]; metal-binding site
439843000740	DNA gyrase inhibitor; Reviewed; Region: PRK00418
439843000741	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582
439843000742	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
439843000743	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
439843000744	CoA-binding site [chemical binding]; other site
439843000745	ATP-binding [chemical binding]; other site
439843000746	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096
439843000747	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
439843000748	active site
439843000749	type IV pilin biogenesis protein; Provisional; Region: PRK10573
439843000750	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
439843000751	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
439843000752	hypothetical protein; Provisional; Region: PRK10436
439843000753	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
439843000754	Walker A motif; other site
439843000755	ATP binding site [chemical binding]; other site
439843000756	Walker B motif; other site
439843000757	putative major pilin subunit; Provisional; Region: PRK10574
439843000758	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
439843000759	Pilin (bacterial filament); Region: Pilin; pfam00114
439843000760	quinolinate phosphoribosyltransferase; Validated; Region: PRK09016
439843000761	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
439843000762	dimerization interface [polypeptide binding]; other site
439843000763	active site
439843000764	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
439843000765	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
439843000766	amidase catalytic site [active]
439843000767	Zn binding residues [ion binding]; other site
439843000768	substrate binding site [chemical binding]; other site
439843000769	regulatory protein AmpE; Provisional; Region: PRK10987
439843000770	Glycosyl hydrolase family 43; Region: GH43_1; cd08980
439843000771	active site
439843000772	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
439843000773	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843000774	putative substrate translocation pore; other site
439843000775	aromatic amino acid transporter; Provisional; Region: PRK10238
439843000776	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
439843000777	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439843000778	DNA-binding site [nucleotide binding]; DNA binding site
439843000779	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
439843000780	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
439843000781	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
439843000782	dimer interface [polypeptide binding]; other site
439843000783	TPP-binding site [chemical binding]; other site
439843000784	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
439843000785	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
439843000786	E3 interaction surface; other site
439843000787	lipoyl attachment site [posttranslational modification]; other site
439843000788	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
439843000789	E3 interaction surface; other site
439843000790	lipoyl attachment site [posttranslational modification]; other site
439843000791	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
439843000792	E3 interaction surface; other site
439843000793	lipoyl attachment site [posttranslational modification]; other site
439843000794	e3 binding domain; Region: E3_binding; pfam02817
439843000795	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
439843000796	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
439843000797	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
439843000798	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
439843000799	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
439843000800	Protein of unknown function (DUF2950); Region: DUF2950; pfam11453
439843000801	Protein of unknown function (DUF3300); Region: DUF3300; pfam11737
439843000802	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
439843000803	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
439843000804	substrate binding site [chemical binding]; other site
439843000805	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
439843000806	substrate binding site [chemical binding]; other site
439843000807	ligand binding site [chemical binding]; other site
439843000808	hypothetical protein; Provisional; Region: PRK05248
439843000809	2-keto-3-deoxygluconate permease; Provisional; Region: PRK12460
439843000810	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
439843000811	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
439843000812	4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371
439843000813	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
439843000814	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
439843000815	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
439843000816	S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462
439843000817	spermidine synthase; Provisional; Region: PRK00811
439843000818	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439843000819	S-adenosylmethionine binding site [chemical binding]; other site
439843000820	Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898
439843000821	multicopper oxidase; Provisional; Region: PRK10965
439843000822	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
439843000823	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
439843000824	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
439843000825	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
439843000826	Trp docking motif [polypeptide binding]; other site
439843000827	putative active site [active]
439843000828	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
439843000829	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
439843000830	active site
439843000831	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
439843000832	active site clefts [active]
439843000833	zinc binding site [ion binding]; other site
439843000834	dimer interface [polypeptide binding]; other site
439843000835	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
439843000836	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
439843000837	Walker A/P-loop; other site
439843000838	ATP binding site [chemical binding]; other site
439843000839	Q-loop/lid; other site
439843000840	ABC transporter signature motif; other site
439843000841	Walker B; other site
439843000842	D-loop; other site
439843000843	H-loop/switch region; other site
439843000844	inner membrane transport permease; Provisional; Region: PRK15066
439843000845	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
439843000846	putative fimbrial protein StiH; Provisional; Region: PRK15297
439843000847	fimbrial outer membrane usher protein StiC; Provisional; Region: PRK15298
439843000848	PapC N-terminal domain; Region: PapC_N; pfam13954
439843000849	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
439843000850	PapC C-terminal domain; Region: PapC_C; pfam13953
439843000851	fimbrial chaperone protein StiB; Provisional; Region: PRK15299
439843000852	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
439843000853	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
439843000854	fimbrial protein StiA; Provisional; Region: PRK15300
439843000855	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
439843000856	active pocket/dimerization site; other site
439843000857	active site
439843000858	phosphorylation site [posttranslational modification]
439843000859	Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966
439843000860	putative active site [active]
439843000861	putative metal binding site [ion binding]; other site
439843000862	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
439843000863	tetramerization interface [polypeptide binding]; other site
439843000864	active site
439843000865	Pantoate-beta-alanine ligase; Region: PanC; cd00560
439843000866	pantoate--beta-alanine ligase; Region: panC; TIGR00018
439843000867	active site
439843000868	ATP-binding site [chemical binding]; other site
439843000869	pantoate-binding site; other site
439843000870	HXXH motif; other site
439843000871	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
439843000872	oligomerization interface [polypeptide binding]; other site
439843000873	active site
439843000874	metal binding site [ion binding]; metal-binding site
439843000875	putative fimbrial-like adhesin protein; Provisional; Region: PRK09723
439843000876	putative fimbrial protein StaF; Provisional; Region: PRK15262
439843000877	putative fimbrial protein StaE; Provisional; Region: PRK15263
439843000878	putative fimbrial protein StaD; Provisional; Region: PRK15241
439843000879	putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828
439843000880	PapC N-terminal domain; Region: PapC_N; pfam13954
439843000881	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
439843000882	PapC C-terminal domain; Region: PapC_C; pfam13953
439843000883	putative chaperone protein EcpD; Provisional; Region: PRK09926
439843000884	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
439843000885	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
439843000886	putative fimbrial protein StaA; Provisional; Region: PRK15239
439843000887	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
439843000888	catalytic center binding site [active]
439843000889	ATP binding site [chemical binding]; other site
439843000890	poly(A) polymerase I; Provisional; Region: pcnB; PRK11623
439843000891	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
439843000892	active site
439843000893	NTP binding site [chemical binding]; other site
439843000894	metal binding triad [ion binding]; metal-binding site
439843000895	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
439843000896	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
439843000897	Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008
439843000898	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
439843000899	active site
439843000900	nucleotide binding site [chemical binding]; other site
439843000901	HIGH motif; other site
439843000902	KMSKS motif; other site
439843000903	RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778
439843000904	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
439843000905	2'-5' RNA ligase; Provisional; Region: PRK15124
439843000906	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
439843000907	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
439843000908	ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664
439843000909	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
439843000910	ATP binding site [chemical binding]; other site
439843000911	putative Mg++ binding site [ion binding]; other site
439843000912	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
439843000913	nucleotide binding region [chemical binding]; other site
439843000914	ATP-binding site [chemical binding]; other site
439843000915	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
439843000916	bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506
439843000917	Transglycosylase; Region: Transgly; pfam00912
439843000918	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
439843000919	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
439843000920	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
439843000921	N-terminal plug; other site
439843000922	ligand-binding site [chemical binding]; other site
439843000923	iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575
439843000924	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
439843000925	Walker A/P-loop; other site
439843000926	ATP binding site [chemical binding]; other site
439843000927	Q-loop/lid; other site
439843000928	ABC transporter signature motif; other site
439843000929	Walker B; other site
439843000930	D-loop; other site
439843000931	H-loop/switch region; other site
439843000932	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
439843000933	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
439843000934	siderophore binding site; other site
439843000935	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
439843000936	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
439843000937	ABC-ATPase subunit  interface; other site
439843000938	dimer interface [polypeptide binding]; other site
439843000939	putative PBP binding regions; other site
439843000940	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
439843000941	ABC-ATPase subunit  interface; other site
439843000942	dimer interface [polypeptide binding]; other site
439843000943	putative PBP binding regions; other site
439843000944	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
439843000945	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
439843000946	inhibitor-cofactor binding pocket; inhibition site
439843000947	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843000948	catalytic residue [active]
439843000949	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
439843000950	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
439843000951	Cl- selectivity filter; other site
439843000952	Cl- binding residues [ion binding]; other site
439843000953	pore gating glutamate residue; other site
439843000954	dimer interface [polypeptide binding]; other site
439843000955	H+/Cl- coupling transport residue; other site
439843000956	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
439843000957	hypothetical protein; Provisional; Region: PRK10578
439843000958	UPF0126 domain; Region: UPF0126; pfam03458
439843000959	UPF0126 domain; Region: UPF0126; pfam03458
439843000960	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
439843000961	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
439843000962	cobalamin binding residues [chemical binding]; other site
439843000963	putative BtuC binding residues; other site
439843000964	dimer interface [polypeptide binding]; other site
439843000965	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
439843000966	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
439843000967	deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926
439843000968	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
439843000969	Zn2+ binding site [ion binding]; other site
439843000970	Mg2+ binding site [ion binding]; other site
439843000971	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
439843000972	serine endoprotease; Provisional; Region: PRK10942
439843000973	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
439843000974	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
439843000975	protein binding site [polypeptide binding]; other site
439843000976	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
439843000977	carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477
439843000978	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
439843000979	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
439843000980	Viral enhancin protein; Region: Enhancin; pfam03272
439843000981	Peptidase M60-like family; Region: M60-like; pfam13402
439843000982	hypothetical protein; Provisional; Region: PRK13677
439843000983	shikimate transporter; Provisional; Region: PRK09952
439843000984	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843000985	putative substrate translocation pore; other site
439843000986	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
439843000987	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
439843000988	trimer interface [polypeptide binding]; other site
439843000989	active site
439843000990	substrate binding site [chemical binding]; other site
439843000991	CoA binding site [chemical binding]; other site
439843000992	PII uridylyl-transferase; Provisional; Region: PRK05007
439843000993	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
439843000994	metal binding triad; other site
439843000995	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
439843000996	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
439843000997	Zn2+ binding site [ion binding]; other site
439843000998	Mg2+ binding site [ion binding]; other site
439843000999	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
439843001000	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
439843001001	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
439843001002	active site
439843001003	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
439843001004	rRNA interaction site [nucleotide binding]; other site
439843001005	S8 interaction site; other site
439843001006	putative laminin-1 binding site; other site
439843001007	elongation factor Ts; Provisional; Region: tsf; PRK09377
439843001008	UBA/TS-N domain; Region: UBA; pfam00627
439843001009	Elongation factor TS; Region: EF_TS; pfam00889
439843001010	Elongation factor TS; Region: EF_TS; pfam00889
439843001011	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
439843001012	putative nucleotide binding site [chemical binding]; other site
439843001013	uridine monophosphate binding site [chemical binding]; other site
439843001014	homohexameric interface [polypeptide binding]; other site
439843001015	ribosome recycling factor; Reviewed; Region: frr; PRK00083
439843001016	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
439843001017	hinge region; other site
439843001018	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
439843001019	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
439843001020	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
439843001021	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
439843001022	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
439843001023	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
439843001024	catalytic residue [active]
439843001025	putative FPP diphosphate  binding site; other site
439843001026	putative FPP binding hydrophobic cleft; other site
439843001027	dimer interface [polypeptide binding]; other site
439843001028	putative IPP diphosphate binding site; other site
439843001029	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
439843001030	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
439843001031	zinc metallopeptidase RseP; Provisional; Region: PRK10779
439843001032	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
439843001033	active site
439843001034	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
439843001035	protein binding site [polypeptide binding]; other site
439843001036	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
439843001037	protein binding site [polypeptide binding]; other site
439843001038	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
439843001039	putative substrate binding region [chemical binding]; other site
439843001040	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
439843001041	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
439843001042	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
439843001043	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
439843001044	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
439843001045	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
439843001046	Surface antigen; Region: Bac_surface_Ag; pfam01103
439843001047	periplasmic chaperone; Provisional; Region: PRK10780
439843001048	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
439843001049	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
439843001050	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
439843001051	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
439843001052	trimer interface [polypeptide binding]; other site
439843001053	active site
439843001054	UDP-GlcNAc binding site [chemical binding]; other site
439843001055	lipid binding site [chemical binding]; lipid-binding site
439843001056	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
439843001057	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
439843001058	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
439843001059	active site
439843001060	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
439843001061	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
439843001062	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
439843001063	RNA/DNA hybrid binding site [nucleotide binding]; other site
439843001064	active site
439843001065	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
439843001066	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
439843001067	putative active site [active]
439843001068	putative PHP Thumb interface [polypeptide binding]; other site
439843001069	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
439843001070	generic binding surface II; other site
439843001071	generic binding surface I; other site
439843001072	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
439843001073	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
439843001074	lysine decarboxylase LdcC; Provisional; Region: PRK15399
439843001075	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
439843001076	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
439843001077	homodimer interface [polypeptide binding]; other site
439843001078	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843001079	catalytic residue [active]
439843001080	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
439843001081	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
439843001082	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
439843001083	putative metal binding site [ion binding]; other site
439843001084	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
439843001085	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
439843001086	Ligand Binding Site [chemical binding]; other site
439843001087	TilS substrate binding domain; Region: TilS; pfam09179
439843001088	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
439843001089	Rho-binding antiterminator; Provisional; Region: PRK11625
439843001090	hypothetical protein; Provisional; Region: PRK04964
439843001091	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681
439843001092	hypothetical protein; Provisional; Region: PRK09256
439843001093	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
439843001094	lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523
439843001095	NlpE N-terminal domain; Region: NlpE; pfam04170
439843001096	prolyl-tRNA synthetase; Provisional; Region: PRK09194
439843001097	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
439843001098	dimer interface [polypeptide binding]; other site
439843001099	motif 1; other site
439843001100	active site
439843001101	motif 2; other site
439843001102	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
439843001103	putative deacylase active site [active]
439843001104	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
439843001105	active site
439843001106	motif 3; other site
439843001107	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
439843001108	anticodon binding site; other site
439843001109	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
439843001110	homodimer interaction site [polypeptide binding]; other site
439843001111	cofactor binding site; other site
439843001112	outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781
439843001113	DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063
439843001114	lipoprotein, YaeC family; Region: TIGR00363
439843001115	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843001116	dimer interface [polypeptide binding]; other site
439843001117	conserved gate region; other site
439843001118	ABC-ATPase subunit interface; other site
439843001119	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
439843001120	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
439843001121	Walker A/P-loop; other site
439843001122	ATP binding site [chemical binding]; other site
439843001123	Q-loop/lid; other site
439843001124	ABC transporter signature motif; other site
439843001125	Walker B; other site
439843001126	D-loop; other site
439843001127	H-loop/switch region; other site
439843001128	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
439843001129	D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213
439843001130	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439843001131	active site
439843001132	motif I; other site
439843001133	motif II; other site
439843001134	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
439843001135	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
439843001136	active site
439843001137	catalytic tetrad [active]
439843001138	Transcriptional regulator [Transcription]; Region: LysR; COG0583
439843001139	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843001140	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478
439843001141	putative effector binding pocket; other site
439843001142	dimerization interface [polypeptide binding]; other site
439843001143	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
439843001144	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843001145	putative substrate translocation pore; other site
439843001146	hypothetical protein; Provisional; Region: PRK05421
439843001147	putative catalytic site [active]
439843001148	putative metal binding site [ion binding]; other site
439843001149	putative phosphate binding site [ion binding]; other site
439843001150	putative catalytic site [active]
439843001151	putative phosphate binding site [ion binding]; other site
439843001152	putative metal binding site [ion binding]; other site
439843001153	Methyltransferase domain; Region: Methyltransf_23; pfam13489
439843001154	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439843001155	S-adenosylmethionine binding site [chemical binding]; other site
439843001156	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
439843001157	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
439843001158	N-acetyl-D-glucosamine binding site [chemical binding]; other site
439843001159	catalytic residue [active]
439843001160	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
439843001161	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
439843001162	hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241
439843001163	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439843001164	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
439843001165	RNA/DNA hybrid binding site [nucleotide binding]; other site
439843001166	active site
439843001167	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
439843001168	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
439843001169	active site
439843001170	catalytic site [active]
439843001171	substrate binding site [chemical binding]; other site
439843001172	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3515
439843001173	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
439843001174	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3520
439843001175	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
439843001176	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
439843001177	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3518
439843001178	Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455
439843001179	ImpE protein; Region: ImpE; pfam07024
439843001180	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
439843001181	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439843001182	Walker A motif; other site
439843001183	ATP binding site [chemical binding]; other site
439843001184	Walker B motif; other site
439843001185	arginine finger; other site
439843001186	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439843001187	Walker A motif; other site
439843001188	ATP binding site [chemical binding]; other site
439843001189	Walker B motif; other site
439843001190	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
439843001191	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3516
439843001192	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517
439843001193	Protein of unknown function (DUF877); Region: DUF877; pfam05943
439843001194	Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion,    and vesicular transport]; Region: Hcp; COG3157
439843001195	Domain of unknown function (DUF4285); Region: DUF4285; pfam14113
439843001196	Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion,    and vesicular transport]; Region: Hcp; COG3157
439843001197	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3521
439843001198	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3522
439843001199	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
439843001200	hypothetical protein; Provisional; Region: PRK08126
439843001201	Type VI protein secretion system component VasF [Intracellular    trafficking, secretion, and vesicular transport]; Region: COG3455
439843001202	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
439843001203	ligand binding site [chemical binding]; other site
439843001204	Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and    vesicular transport]; Region: IcmF; COG3523
439843001205	Protein of unknown function (DUF3036); Region: DUF3036; pfam11234
439843001206	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
439843001207	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
439843001208	Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611
439843001209	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
439843001210	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
439843001211	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
439843001212	Uncharacterized conserved protein [Function unknown]; Region: COG5435
439843001213	Saf-pilin pilus formation protein SafA; Provisional; Region: PRK15221
439843001214	pili assembly chaperone protein SafB; Provisional; Region: PRK15224
439843001215	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
439843001216	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
439843001217	pilin outer membrane usher protein SafC; Provisional; Region: PRK15223
439843001218	PapC N-terminal domain; Region: PapC_N; pfam13954
439843001219	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
439843001220	PapC C-terminal domain; Region: PapC_C; pfam13953
439843001221	putative pilin structural protein SafD; Provisional; Region: PRK15222
439843001222	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
439843001223	Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969
439843001224	putative active site [active]
439843001225	putative metal binding site [ion binding]; other site
439843001226	Transcriptional regulator [Transcription]; Region: LysR; COG0583
439843001227	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843001228	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
439843001229	dimerization interface [polypeptide binding]; other site
439843001230	putative fimbrial protein TcfA; Provisional; Region: PRK15308
439843001231	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
439843001232	putative fimbrial subunit TcfB; Provisional; Region: PRK15309
439843001233	fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310
439843001234	putative fimbrial protein TcfD; Provisional; Region: PRK15311
439843001235	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
439843001236	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
439843001237	AsnC family; Region: AsnC_trans_reg; pfam01037
439843001238	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
439843001239	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
439843001240	dimer interface [polypeptide binding]; other site
439843001241	C-N hydrolase family amidase; Provisional; Region: PRK10438
439843001242	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
439843001243	putative active site [active]
439843001244	catalytic triad [active]
439843001245	dimer interface [polypeptide binding]; other site
439843001246	multimer interface [polypeptide binding]; other site
439843001247	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
439843001248	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
439843001249	active site
439843001250	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
439843001251	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
439843001252	dimer interface [polypeptide binding]; other site
439843001253	active site
439843001254	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
439843001255	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
439843001256	putative active site [active]
439843001257	putative dimer interface [polypeptide binding]; other site
439843001258	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
439843001259	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
439843001260	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
439843001261	active site
439843001262	DNA polymerase IV; Validated; Region: PRK02406
439843001263	DNA binding site [nucleotide binding]
439843001264	hypothetical protein; Reviewed; Region: PRK09588
439843001265	release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073
439843001266	peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179
439843001267	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
439843001268	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
439843001269	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
439843001270	metal binding site [ion binding]; metal-binding site
439843001271	dimer interface [polypeptide binding]; other site
439843001272	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
439843001273	active site
439843001274	fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077
439843001275	DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984
439843001276	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
439843001277	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
439843001278	trimer interface [polypeptide binding]; other site
439843001279	eyelet of channel; other site
439843001280	gamma-glutamyl kinase; Provisional; Region: PRK05429
439843001281	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
439843001282	nucleotide binding site [chemical binding]; other site
439843001283	homotetrameric interface [polypeptide binding]; other site
439843001284	putative phosphate binding site [ion binding]; other site
439843001285	putative allosteric binding site; other site
439843001286	PUA domain; Region: PUA; pfam01472
439843001287	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
439843001288	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
439843001289	putative catalytic cysteine [active]
439843001290	integrase; Provisional; Region: PRK09692
439843001291	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
439843001292	active site
439843001293	Int/Topo IB signature motif; other site
439843001294	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
439843001295	Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778
439843001296	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
439843001297	active site
439843001298	metal binding site [ion binding]; metal-binding site
439843001299	interdomain interaction site; other site
439843001300	Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519
439843001301	Phage polarity suppression protein (Psu); Region: Psu; pfam07455
439843001302	Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606
439843001303	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439843001304	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
439843001305	Walker A motif; other site
439843001306	ATP binding site [chemical binding]; other site
439843001307	Walker B motif; other site
439843001308	arginine finger; other site
439843001309	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
439843001310	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
439843001311	active site
439843001312	catalytic triad [active]
439843001313	fimbrial assembly chaperone StbE; Provisional; Region: PRK15246
439843001314	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
439843001315	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
439843001316	putative fimbrial usher protein StbD; Provisional; Region: PRK15247
439843001317	fimbrial outer membrane usher protein StbC; Provisional; Region: PRK15248
439843001318	PapC N-terminal domain; Region: PapC_N; pfam13954
439843001319	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
439843001320	PapC C-terminal domain; Region: PapC_C; pfam13953
439843001321	fimbrial chaperone protein StbB; Provisional; Region: PRK15249
439843001322	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
439843001323	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
439843001324	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
439843001325	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
439843001326	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
439843001327	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
439843001328	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
439843001329	DNA binding site [nucleotide binding]
439843001330	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
439843001331	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
439843001332	DNA binding residues [nucleotide binding]
439843001333	dimerization interface [polypeptide binding]; other site
439843001334	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
439843001335	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
439843001336	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
439843001337	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
439843001338	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
439843001339	HlyD family secretion protein; Region: HlyD_3; pfam13437
439843001340	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
439843001341	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
439843001342	metal-binding site [ion binding]
439843001343	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
439843001344	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439843001345	motif II; other site
439843001346	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
439843001347	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
439843001348	DNA binding residues [nucleotide binding]
439843001349	dimer interface [polypeptide binding]; other site
439843001350	copper binding site [ion binding]; other site
439843001351	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
439843001352	metal-binding site [ion binding]
439843001353	putative sialic acid transporter; Region: 2A0112; TIGR00891
439843001354	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843001355	putative substrate translocation pore; other site
439843001356	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
439843001357	DNA methylase; Region: N6_N4_Mtase; cl17433
439843001358	DNA methylase; Region: N6_N4_Mtase; pfam01555
439843001359	type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483
439843001360	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
439843001361	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
439843001362	VRR-NUC domain; Region: VRR_NUC; pfam08774
439843001363	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
439843001364	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
439843001365	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
439843001366	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
439843001367	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
439843001368	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
439843001369	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
439843001370	N-terminal plug; other site
439843001371	ligand-binding site [chemical binding]; other site
439843001372	The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949
439843001373	hypothetical protein; Provisional; Region: PRK09929
439843001374	propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424
439843001375	Propionate catabolism activator; Region: PrpR_N; pfam06506
439843001376	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439843001377	Walker A motif; other site
439843001378	ATP binding site [chemical binding]; other site
439843001379	Walker B motif; other site
439843001380	arginine finger; other site
439843001381	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
439843001382	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
439843001383	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
439843001384	tetramer interface [polypeptide binding]; other site
439843001385	active site
439843001386	Mg2+/Mn2+ binding site [ion binding]; other site
439843001387	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
439843001388	Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117
439843001389	dimer interface [polypeptide binding]; other site
439843001390	active site
439843001391	citrylCoA binding site [chemical binding]; other site
439843001392	oxalacetate/citrate binding site [chemical binding]; other site
439843001393	coenzyme A binding site [chemical binding]; other site
439843001394	catalytic triad [active]
439843001395	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
439843001396	2-methylcitrate dehydratase; Region: prpD; TIGR02330
439843001397	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
439843001398	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
439843001399	acyl-activating enzyme (AAE) consensus motif; other site
439843001400	AMP binding site [chemical binding]; other site
439843001401	active site
439843001402	CoA binding site [chemical binding]; other site
439843001403	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
439843001404	dimer interface [polypeptide binding]; other site
439843001405	active site
439843001406	Schiff base residues; other site
439843001407	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253
439843001408	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
439843001409	Autotransporter beta-domain; Region: Autotransporter; pfam03797
439843001410	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832
439843001411	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
439843001412	ligand binding site [chemical binding]; other site
439843001413	flexible hinge region; other site
439843001414	beta-lactam binding protein AmpH; Provisional; Region: PRK10662
439843001415	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
439843001416	microcin B17 transporter; Reviewed; Region: PRK11098
439843001417	Protein of unknown function (DUF1615); Region: DUF1615; pfam07759
439843001418	Protein of unknown function (DUF2755); Region: DUF2755; pfam10954
439843001419	Protein of unknown function (DUF2754); Region: DUF2754; pfam10953
439843001420	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
439843001421	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
439843001422	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
439843001423	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921
439843001424	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
439843001425	drug efflux system protein MdtG; Provisional; Region: PRK09874
439843001426	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843001427	putative substrate translocation pore; other site
439843001428	anti-RssB factor; Provisional; Region: PRK10244
439843001429	hypothetical protein; Provisional; Region: PRK11505
439843001430	psiF repeat; Region: PsiF_repeat; pfam07769
439843001431	psiF repeat; Region: PsiF_repeat; pfam07769
439843001432	diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245
439843001433	MASE2 domain; Region: MASE2; pfam05230
439843001434	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
439843001435	metal binding site [ion binding]; metal-binding site
439843001436	active site
439843001437	I-site; other site
439843001438	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
439843001439	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
439843001440	hypothetical protein; Validated; Region: PRK00124
439843001441	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
439843001442	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
439843001443	ADP binding site [chemical binding]; other site
439843001444	magnesium binding site [ion binding]; other site
439843001445	putative shikimate binding site; other site
439843001446	hypothetical protein; Provisional; Region: PRK10380
439843001447	hypothetical protein; Provisional; Region: PRK10481
439843001448	hypothetical protein; Provisional; Region: PRK10579
439843001449	DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974
439843001450	fructokinase; Reviewed; Region: PRK09557
439843001451	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
439843001452	nucleotide binding site [chemical binding]; other site
439843001453	MFS transport protein AraJ; Provisional; Region: PRK10091
439843001454	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843001455	putative substrate translocation pore; other site
439843001456	exonuclease subunit SbcC; Provisional; Region: PRK10246
439843001457	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439843001458	Walker A/P-loop; other site
439843001459	ATP binding site [chemical binding]; other site
439843001460	Q-loop/lid; other site
439843001461	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439843001462	ABC transporter signature motif; other site
439843001463	Walker B; other site
439843001464	D-loop; other site
439843001465	H-loop/switch region; other site
439843001466	exonuclease subunit SbcD; Provisional; Region: PRK10966
439843001467	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
439843001468	active site
439843001469	metal binding site [ion binding]; metal-binding site
439843001470	DNA binding site [nucleotide binding]
439843001471	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
439843001472	transcriptional regulator PhoB; Provisional; Region: PRK10161
439843001473	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843001474	active site
439843001475	phosphorylation site [posttranslational modification]
439843001476	intermolecular recognition site; other site
439843001477	dimerization interface [polypeptide binding]; other site
439843001478	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
439843001479	DNA binding site [nucleotide binding]
439843001480	phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006
439843001481	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
439843001482	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
439843001483	putative active site [active]
439843001484	heme pocket [chemical binding]; other site
439843001485	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439843001486	dimer interface [polypeptide binding]; other site
439843001487	phosphorylation site [posttranslational modification]
439843001488	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439843001489	ATP binding site [chemical binding]; other site
439843001490	Mg2+ binding site [ion binding]; other site
439843001491	G-X-G motif; other site
439843001492	branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433
439843001493	putative proline-specific permease; Provisional; Region: proY; PRK10580
439843001494	maltodextrin glucosidase; Provisional; Region: PRK10785
439843001495	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
439843001496	homodimer interface [polypeptide binding]; other site
439843001497	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
439843001498	active site
439843001499	homodimer interface [polypeptide binding]; other site
439843001500	catalytic site [active]
439843001501	peroxidase; Provisional; Region: PRK15000
439843001502	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
439843001503	dimer interface [polypeptide binding]; other site
439843001504	decamer (pentamer of dimers) interface [polypeptide binding]; other site
439843001505	catalytic triad [active]
439843001506	peroxidatic and resolving cysteines [active]
439843001507	acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045
439843001508	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
439843001509	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
439843001510	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
439843001511	tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449
439843001512	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
439843001513	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
439843001514	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
439843001515	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
439843001516	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
439843001517	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
439843001518	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
439843001519	Protein export membrane protein; Region: SecD_SecF; pfam02355
439843001520	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
439843001521	active site
439843001522	nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106
439843001523	hypothetical protein; Provisional; Region: PRK11530
439843001524	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
439843001525	ATP cone domain; Region: ATP-cone; pfam03477
439843001526	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
439843001527	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
439843001528	catalytic motif [active]
439843001529	Zn binding site [ion binding]; other site
439843001530	riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227
439843001531	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
439843001532	homopentamer interface [polypeptide binding]; other site
439843001533	active site
439843001534	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
439843001535	putative RNA binding site [nucleotide binding]; other site
439843001536	thiamine monophosphate kinase; Provisional; Region: PRK05731
439843001537	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
439843001538	ATP binding site [chemical binding]; other site
439843001539	dimerization interface [polypeptide binding]; other site
439843001540	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
439843001541	tetramer interfaces [polypeptide binding]; other site
439843001542	binuclear metal-binding site [ion binding]; other site
439843001543	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
439843001544	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
439843001545	active site
439843001546	catalytic tetrad [active]
439843001547	1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204
439843001548	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
439843001549	TPP-binding site; other site
439843001550	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
439843001551	PYR/PP interface [polypeptide binding]; other site
439843001552	dimer interface [polypeptide binding]; other site
439843001553	TPP binding site [chemical binding]; other site
439843001554	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
439843001555	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
439843001556	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
439843001557	substrate binding pocket [chemical binding]; other site
439843001558	chain length determination region; other site
439843001559	substrate-Mg2+ binding site; other site
439843001560	catalytic residues [active]
439843001561	aspartate-rich region 1; other site
439843001562	active site lid residues [active]
439843001563	aspartate-rich region 2; other site
439843001564	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
439843001565	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
439843001566	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
439843001567	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
439843001568	Ligand Binding Site [chemical binding]; other site
439843001569	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
439843001570	active site residue [active]
439843001571	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
439843001572	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843001573	dimer interface [polypeptide binding]; other site
439843001574	conserved gate region; other site
439843001575	ABC-ATPase subunit interface; other site
439843001576	2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050
439843001577	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843001578	dimer interface [polypeptide binding]; other site
439843001579	conserved gate region; other site
439843001580	putative PBP binding loops; other site
439843001581	ABC-ATPase subunit interface; other site
439843001582	2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258
439843001583	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439843001584	Walker A/P-loop; other site
439843001585	ATP binding site [chemical binding]; other site
439843001586	Q-loop/lid; other site
439843001587	ABC transporter signature motif; other site
439843001588	Walker B; other site
439843001589	D-loop; other site
439843001590	H-loop/switch region; other site
439843001591	TOBE domain; Region: TOBE_2; pfam08402
439843001592	2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046
439843001593	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
439843001594	transcriptional regulator protein; Region: phnR; TIGR03337
439843001595	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439843001596	DNA-binding site [nucleotide binding]; DNA binding site
439843001597	UTRA domain; Region: UTRA; pfam07702
439843001598	2-aminoethylphosphonate--pyruvate transaminase; Region: transamin_PhnW; TIGR02326
439843001599	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
439843001600	catalytic residue [active]
439843001601	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
439843001602	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439843001603	motif II; other site
439843001604	oxidative-stress-resistance chaperone; Provisional; Region: PRK11574
439843001605	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
439843001606	conserved cys residue [active]
439843001607	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
439843001608	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
439843001609	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
439843001610	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
439843001611	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
439843001612	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843001613	Major Facilitator Superfamily; Region: MFS_1; pfam07690
439843001614	putative substrate translocation pore; other site
439843001615	protoheme IX farnesyltransferase; Provisional; Region: PRK13362
439843001616	UbiA prenyltransferase family; Region: UbiA; pfam01040
439843001617	cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582
439843001618	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
439843001619	Subunit I/III interface [polypeptide binding]; other site
439843001620	Subunit III/IV interface [polypeptide binding]; other site
439843001621	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
439843001622	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
439843001623	D-pathway; other site
439843001624	Putative ubiquinol binding site [chemical binding]; other site
439843001625	Low-spin heme (heme b) binding site [chemical binding]; other site
439843001626	Putative water exit pathway; other site
439843001627	Binuclear center (heme o3/CuB) [ion binding]; other site
439843001628	K-pathway; other site
439843001629	Putative proton exit pathway; other site
439843001630	cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525
439843001631	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
439843001632	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
439843001633	muropeptide transporter; Reviewed; Region: ampG; PRK11902
439843001634	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843001635	putative substrate translocation pore; other site
439843001636	hypothetical protein; Provisional; Region: PRK11627
439843001637	Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923
439843001638	transcriptional regulator BolA; Provisional; Region: PRK11628
439843001639	trigger factor; Provisional; Region: tig; PRK01490
439843001640	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
439843001641	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
439843001642	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
439843001643	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
439843001644	oligomer interface [polypeptide binding]; other site
439843001645	active site residues [active]
439843001646	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
439843001647	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
439843001648	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439843001649	Walker A motif; other site
439843001650	ATP binding site [chemical binding]; other site
439843001651	Walker B motif; other site
439843001652	Iron permease FTR1 family; Region: FTR1; cl00475
439843001653	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
439843001654	DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787
439843001655	Found in ATP-dependent protease La (LON); Region: LON; smart00464
439843001656	Found in ATP-dependent protease La (LON); Region: LON; smart00464
439843001657	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439843001658	Walker A motif; other site
439843001659	ATP binding site [chemical binding]; other site
439843001660	Walker B motif; other site
439843001661	arginine finger; other site
439843001662	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
439843001663	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
439843001664	IHF dimer interface [polypeptide binding]; other site
439843001665	IHF - DNA interface [nucleotide binding]; other site
439843001666	periplasmic folding chaperone; Provisional; Region: PRK10788
439843001667	SurA N-terminal domain; Region: SurA_N_3; cl07813
439843001668	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
439843001669	competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426
439843001670	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
439843001671	active site
439843001672	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
439843001673	Ligand Binding Site [chemical binding]; other site
439843001674	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
439843001675	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
439843001676	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
439843001677	thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126
439843001678	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439843001679	active site
439843001680	motif I; other site
439843001681	motif II; other site
439843001682	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
439843001683	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
439843001684	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
439843001685	catalytic residue [active]
439843001686	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
439843001687	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
439843001688	putative DNA binding site [nucleotide binding]; other site
439843001689	putative Zn2+ binding site [ion binding]; other site
439843001690	AsnC family; Region: AsnC_trans_reg; pfam01037
439843001691	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
439843001692	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
439843001693	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439843001694	Walker A/P-loop; other site
439843001695	ATP binding site [chemical binding]; other site
439843001696	Q-loop/lid; other site
439843001697	ABC transporter signature motif; other site
439843001698	Walker B; other site
439843001699	D-loop; other site
439843001700	H-loop/switch region; other site
439843001701	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790
439843001702	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
439843001703	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439843001704	Walker A/P-loop; other site
439843001705	ATP binding site [chemical binding]; other site
439843001706	Q-loop/lid; other site
439843001707	ABC transporter signature motif; other site
439843001708	Walker B; other site
439843001709	D-loop; other site
439843001710	H-loop/switch region; other site
439843001711	nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665
439843001712	Nitrogen regulatory protein P-II; Region: P-II; smart00938
439843001713	ammonium transporter; Provisional; Region: PRK10666
439843001714	acyl-CoA thioesterase II; Provisional; Region: PRK10526
439843001715	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
439843001716	active site
439843001717	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
439843001718	catalytic triad [active]
439843001719	dimer interface [polypeptide binding]; other site
439843001720	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126
439843001721	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
439843001722	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
439843001723	DNA binding site [nucleotide binding]
439843001724	active site
439843001725	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
439843001726	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
439843001727	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
439843001728	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
439843001729	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
439843001730	sigma70 family sigma factor YlaC; Region: YlaC; pfam10777
439843001731	maltose O-acetyltransferase; Provisional; Region: PRK10092
439843001732	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
439843001733	active site
439843001734	substrate binding site [chemical binding]; other site
439843001735	trimer interface [polypeptide binding]; other site
439843001736	CoA binding site [chemical binding]; other site
439843001737	gene expression modulator; Provisional; Region: PRK10945
439843001738	Hha toxicity attenuator; Provisional; Region: PRK10667
439843001739	multidrug efflux system protein AcrB; Provisional; Region: PRK15127
439843001740	Protein export membrane protein; Region: SecD_SecF; cl14618
439843001741	Protein export membrane protein; Region: SecD_SecF; cl14618
439843001742	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
439843001743	HlyD family secretion protein; Region: HlyD_3; pfam13437
439843001744	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
439843001745	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
439843001746	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
439843001747	hypothetical protein; Provisional; Region: PRK11281
439843001748	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
439843001749	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
439843001750	Mechanosensitive ion channel; Region: MS_channel; pfam00924
439843001751	Uncharacterized conserved protein [Function unknown]; Region: COG5464
439843001752	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
439843001753	hypothetical protein; Provisional; Region: PRK11038
439843001754	primosomal replication protein N''; Provisional; Region: PRK10093
439843001755	hypothetical protein; Provisional; Region: PRK10527
439843001756	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
439843001757	active site
439843001758	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
439843001759	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439843001760	Walker A motif; other site
439843001761	ATP binding site [chemical binding]; other site
439843001762	Walker B motif; other site
439843001763	DNA polymerase III subunit delta'; Validated; Region: PRK08485
439843001764	arginine finger; other site
439843001765	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
439843001766	DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168
439843001767	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
439843001768	DnaX ribosomal frameshifting element
439843001769	hypothetical protein; Validated; Region: PRK00153
439843001770	recombination protein RecR; Reviewed; Region: recR; PRK00076
439843001771	RecR protein; Region: RecR; pfam02132
439843001772	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
439843001773	putative active site [active]
439843001774	putative metal-binding site [ion binding]; other site
439843001775	tetramer interface [polypeptide binding]; other site
439843001776	heat shock protein 90; Provisional; Region: PRK05218
439843001777	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439843001778	ATP binding site [chemical binding]; other site
439843001779	Mg2+ binding site [ion binding]; other site
439843001780	G-X-G motif; other site
439843001781	adenylate kinase; Reviewed; Region: adk; PRK00279
439843001782	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
439843001783	AMP-binding site [chemical binding]; other site
439843001784	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
439843001785	ferrochelatase; Reviewed; Region: hemH; PRK00035
439843001786	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
439843001787	C-terminal domain interface [polypeptide binding]; other site
439843001788	active site
439843001789	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
439843001790	active site
439843001791	N-terminal domain interface [polypeptide binding]; other site
439843001792	acetyl esterase; Provisional; Region: PRK10162
439843001793	inosine/guanosine kinase; Provisional; Region: PRK15074
439843001794	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
439843001795	putative cation:proton antiport protein; Provisional; Region: PRK10669
439843001796	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
439843001797	TrkA-N domain; Region: TrkA_N; pfam02254
439843001798	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843001799	Major Facilitator Superfamily; Region: MFS_1; pfam07690
439843001800	putative substrate translocation pore; other site
439843001801	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
439843001802	Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405
439843001803	active site
439843001804	metal binding site [ion binding]; metal-binding site
439843001805	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
439843001806	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
439843001807	putative deacylase active site [active]
439843001808	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735
439843001809	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
439843001810	copper exporting ATPase; Provisional; Region: copA; PRK10671
439843001811	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
439843001812	metal-binding site [ion binding]
439843001813	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
439843001814	metal-binding site [ion binding]
439843001815	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
439843001816	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439843001817	motif II; other site
439843001818	DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227
439843001819	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
439843001820	DNA binding residues [nucleotide binding]
439843001821	dimer interface [polypeptide binding]; other site
439843001822	copper binding site [ion binding]; other site
439843001823	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
439843001824	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
439843001825	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
439843001826	putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247
439843001827	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
439843001828	Walker A/P-loop; other site
439843001829	ATP binding site [chemical binding]; other site
439843001830	Q-loop/lid; other site
439843001831	ABC transporter signature motif; other site
439843001832	Walker B; other site
439843001833	D-loop; other site
439843001834	H-loop/switch region; other site
439843001835	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
439843001836	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
439843001837	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
439843001838	oxidoreductase; Provisional; Region: PRK08017
439843001839	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
439843001840	NADP binding site [chemical binding]; other site
439843001841	active site
439843001842	steroid binding site; other site
439843001843	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
439843001844	active site
439843001845	catalytic triad [active]
439843001846	oxyanion hole [active]
439843001847	switch loop; other site
439843001848	putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584
439843001849	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
439843001850	Walker A/P-loop; other site
439843001851	ATP binding site [chemical binding]; other site
439843001852	Q-loop/lid; other site
439843001853	ABC transporter signature motif; other site
439843001854	Walker B; other site
439843001855	D-loop; other site
439843001856	H-loop/switch region; other site
439843001857	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
439843001858	FtsX-like permease family; Region: FtsX; pfam02687
439843001859	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
439843001860	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
439843001861	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
439843001862	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
439843001863	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
439843001864	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
439843001865	Walker A/P-loop; other site
439843001866	ATP binding site [chemical binding]; other site
439843001867	Q-loop/lid; other site
439843001868	ABC transporter signature motif; other site
439843001869	Walker B; other site
439843001870	D-loop; other site
439843001871	H-loop/switch region; other site
439843001872	NIL domain; Region: NIL; pfam09383
439843001873	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843001874	dimer interface [polypeptide binding]; other site
439843001875	conserved gate region; other site
439843001876	ABC-ATPase subunit interface; other site
439843001877	Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520
439843001878	Predicted ATPase [General function prediction only]; Region: COG2603
439843001879	active site residue [active]
439843001880	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
439843001881	ATP-grasp domain; Region: ATP-grasp; pfam02222
439843001882	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
439843001883	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
439843001884	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
439843001885	putative active site [active]
439843001886	putative metal binding site [ion binding]; other site
439843001887	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
439843001888	substrate binding site [chemical binding]; other site
439843001889	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
439843001890	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
439843001891	active site
439843001892	HIGH motif; other site
439843001893	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
439843001894	KMSKS motif; other site
439843001895	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
439843001896	tRNA binding surface [nucleotide binding]; other site
439843001897	anticodon binding site; other site
439843001898	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4727
439843001899	Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916
439843001900	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
439843001901	ribosome-associated protein; Provisional; Region: PRK11507
439843001902	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
439843001903	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
439843001904	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
439843001905	homodimer interface [polypeptide binding]; other site
439843001906	NADP binding site [chemical binding]; other site
439843001907	substrate binding site [chemical binding]; other site
439843001908	type-1 fimbrial protein subunit A; Provisional; Region: PRK15194
439843001909	fimbrial protein FimI; Provisional; Region: PRK15200
439843001910	fimbrial chaperone protein FimC; Provisional; Region: PRK15195
439843001911	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
439843001912	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
439843001913	outer membrane usher protein FimD; Provisional; Region: PRK15198
439843001914	PapC N-terminal domain; Region: PapC_N; pfam13954
439843001915	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
439843001916	PapC C-terminal domain; Region: PapC_C; pfam13953
439843001917	fimbrial-like adhesin; Provisional; Region: fimH; PRK15199
439843001918	fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934
439843001919	transcriptional regulator FimZ; Provisional; Region: PRK09935
439843001920	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843001921	active site
439843001922	phosphorylation site [posttranslational modification]
439843001923	intermolecular recognition site; other site
439843001924	dimerization interface [polypeptide binding]; other site
439843001925	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
439843001926	DNA binding residues [nucleotide binding]
439843001927	dimerization interface [polypeptide binding]; other site
439843001928	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
439843001929	fimbriae regulatory protein FimW; Provisional; Region: PRK15201
439843001930	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
439843001931	DNA binding residues [nucleotide binding]
439843001932	dimerization interface [polypeptide binding]; other site
439843001933	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
439843001934	P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192
439843001935	Int/Topo IB signature motif; other site
439843001936	Protein of unknown function (DUF551); Region: DUF551; pfam04448
439843001937	Protein of unknown function (DUF551); Region: DUF551; pfam04448
439843001938	Mediator of RNA polymerase II transcription complex subunit 8; Region: Med8; pfam10232
439843001939	Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935
439843001940	Protein of unknown function (DUF2737); Region: DUF2737; pfam10930
439843001941	Protein of unknown function (DUF2856); Region: DUF2856; pfam11043
439843001942	Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301
439843001943	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
439843001944	non-specific DNA binding site [nucleotide binding]; other site
439843001945	salt bridge; other site
439843001946	sequence-specific DNA binding site [nucleotide binding]; other site
439843001947	Bacteriophage CII protein; Region: Phage_CII; pfam05269
439843001948	Protein of unknown function (DUF2740); Region: DUF2740; pfam10872
439843001949	Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492
439843001950	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
439843001951	active site
439843001952	metal binding site [ion binding]; metal-binding site
439843001953	interdomain interaction site; other site
439843001954	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
439843001955	Walker A motif; other site
439843001956	ATP binding site [chemical binding]; other site
439843001957	AAA domain; Region: AAA_25; pfam13481
439843001958	Walker B motif; other site
439843001959	NinF protein; Region: NinF; pfam05810
439843001960	Endodeoxyribonuclease RusA; Region: RusA; cl01885
439843001961	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402
439843001962	DNA binding site [nucleotide binding]
439843001963	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
439843001964	catalytic residues [active]
439843001965	KilA-N domain; Region: KilA-N; pfam04383
439843001966	ORF11CD3 domain; Region: ORF11CD3; pfam10549
439843001967	Phage terminase large subunit; Region: Terminase_3; cl12054
439843001968	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
439843001969	Phage major tail protein 2; Region: Phage_tail_2; pfam06199
439843001970	Immunoglobulin like; Region: IG_like; smart00410
439843001971	KilA-N domain; Region: KilA-N; pfam04383
439843001972	P63C domain; Region: P63C; pfam10546
439843001973	BRO family, N-terminal domain; Region: Bro-N; smart01040
439843001974	P22AR C-terminal domain; Region: P22_AR_C; pfam10548
439843001975	ORF6N domain; Region: ORF6N; pfam10543
439843001976	KilA-N domain; Region: KilA-N; pfam04383
439843001977	P22AR C-terminal domain; Region: P22_AR_C; pfam10548
439843001978	Phage-related minor tail protein [Function unknown]; Region: COG5281
439843001979	tape measure domain; Region: tape_meas_nterm; TIGR02675
439843001980	Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120
439843001981	Phage minor tail protein; Region: Phage_min_tail; pfam05939
439843001982	Phage-related protein [Function unknown]; Region: gp18; COG4672
439843001983	Phage-related protein, tail component [Function unknown]; Region: COG4733
439843001984	Putative phage tail protein; Region: Phage-tail_3; pfam13550
439843001985	Domain of unknown function (DUF1983); Region: DUF1983; pfam09327
439843001986	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
439843001987	integrase; Provisional; Region: PRK09692
439843001988	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
439843001989	active site
439843001990	Int/Topo IB signature motif; other site
439843001991	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
439843001992	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713
439843001993	ORF6N domain; Region: ORF6N; pfam10543
439843001994	Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519
439843001995	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
439843001996	dimer interface [polypeptide binding]; other site
439843001997	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
439843001998	ssDNA binding site [nucleotide binding]; other site
439843001999	tetramer (dimer of dimers) interface [polypeptide binding]; other site
439843002000	Antitermination protein; Region: Antiterm; pfam03589
439843002001	Antitermination protein; Region: Antiterm; pfam03589
439843002002	Phage holin family (Lysis protein S); Region: Phage_holin_3; pfam05106
439843002003	Predicted chitinase [General function prediction only]; Region: COG3179
439843002004	Protein of unknown function (DUF2514); Region: DUF2514; pfam10721
439843002005	Protein of unknown function (DUF1441); Region: DUF1441; pfam07278
439843002006	Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525
439843002007	Bacteriophage capsid protein [General function prediction only]; Region: COG5511
439843002008	phage portal protein, lambda family; Region: portal_lambda; TIGR01539
439843002009	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
439843002010	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
439843002011	oligomer interface [polypeptide binding]; other site
439843002012	active site residues [active]
439843002013	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826
439843002014	Uncharacterized conserved protein (DUF2190); Region: DUF2190; cl02289
439843002015	ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856
439843002016	Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763
439843002017	Phage minor tail protein U; Region: Phage_tail_U; pfam06141
439843002018	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
439843002019	Phage tail protein; Region: Phage_tail_3; pfam08813
439843002020	Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894
439843002021	Minor tail protein T; Region: Phage_tail_T; cl05636
439843002022	Phage-related minor tail protein [Function unknown]; Region: COG5281
439843002023	Prophage tail length tape measure protein; Region: TMP_2; pfam06791
439843002024	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718
439843002025	Phage-related protein [Function unknown]; Region: COG4718
439843002026	Phage-related protein [Function unknown]; Region: gp18; COG4672
439843002027	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073
439843002028	MPN+ (JAMM) motif; other site
439843002029	Zinc-binding site [ion binding]; other site
439843002030	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
439843002031	NlpC/P60 family; Region: NLPC_P60; cl17555
439843002032	Phage-related protein, tail component [Function unknown]; Region: COG4723
439843002033	Phage-related protein, tail component [Function unknown]; Region: COG4733
439843002034	Putative phage tail protein; Region: Phage-tail_3; pfam13550
439843002035	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
439843002036	Interdomain contacts; other site
439843002037	Cytokine receptor motif; other site
439843002038	Domain of unknown function (DUF1983); Region: DUF1983; pfam09327
439843002039	Fibronectin type III protein; Region: DUF3672; pfam12421
439843002040	Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400
439843002041	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
439843002042	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
439843002043	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
439843002044	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
439843002045	substrate binding pocket [chemical binding]; other site
439843002046	membrane-bound complex binding site; other site
439843002047	hinge residues; other site
439843002048	hypothetical protein; Provisional; Region: PRK09951
439843002049	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
439843002050	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
439843002051	arsenical pump membrane protein; Provisional; Region: PRK15445
439843002052	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
439843002053	transmembrane helices; other site
439843002054	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
439843002055	ArsC family; Region: ArsC; pfam03960
439843002056	catalytic residues [active]
439843002057	DinI-like family; Region: DinI; cl11630
439843002058	Transposase; Region: HTH_Tnp_1; pfam01527
439843002059	Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304
439843002060	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
439843002061	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
439843002062	Ligand binding site; other site
439843002063	Putative Catalytic site; other site
439843002064	DXD motif; other site
439843002065	Predicted membrane protein [Function unknown]; Region: COG2246
439843002066	GtrA-like protein; Region: GtrA; pfam04138
439843002067	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439843002068	ATP binding site [chemical binding]; other site
439843002069	Mg2+ binding site [ion binding]; other site
439843002070	G-X-G motif; other site
439843002071	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
439843002072	Cupin; Region: Cupin_6; pfam12852
439843002073	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
439843002074	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439843002075	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010
439843002076	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
439843002077	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
439843002078	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
439843002079	Predicted membrane protein [Function unknown]; Region: COG3059
439843002080	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
439843002081	phenylalanine transporter; Provisional; Region: PRK10249
439843002082	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
439843002083	Mechanosensitive ion channel; Region: MS_channel; pfam00924
439843002084	Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240
439843002085	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
439843002086	active site
439843002087	oxyanion hole [active]
439843002088	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
439843002089	catalytic triad [active]
439843002090	Autotransporter beta-domain; Region: Autotransporter; cl17461
439843002091	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
439843002092	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439843002093	Protein of unknown function (DUF1158); Region: DUF1158; pfam06643
439843002094	gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516
439843002095	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
439843002096	phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251
439843002097	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
439843002098	outer membrane receptor FepA; Provisional; Region: PRK13524
439843002099	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
439843002100	N-terminal plug; other site
439843002101	ligand-binding site [chemical binding]; other site
439843002102	enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439
439843002103	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
439843002104	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
439843002105	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251
439843002106	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
439843002107	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
439843002108	acyl-activating enzyme (AAE) consensus motif; other site
439843002109	AMP binding site [chemical binding]; other site
439843002110	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
439843002111	LPS O-antigen length regulator; Provisional; Region: PRK10381
439843002112	Chain length determinant protein; Region: Wzz; pfam02706
439843002113	iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253
439843002114	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
439843002115	Walker A/P-loop; other site
439843002116	ATP binding site [chemical binding]; other site
439843002117	Q-loop/lid; other site
439843002118	ABC transporter signature motif; other site
439843002119	Walker B; other site
439843002120	D-loop; other site
439843002121	H-loop/switch region; other site
439843002122	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
439843002123	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
439843002124	ABC-ATPase subunit  interface; other site
439843002125	dimer interface [polypeptide binding]; other site
439843002126	putative PBP binding regions; other site
439843002127	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
439843002128	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
439843002129	ABC-ATPase subunit  interface; other site
439843002130	dimer interface [polypeptide binding]; other site
439843002131	putative PBP binding regions; other site
439843002132	enterobactin exporter EntS; Provisional; Region: PRK10489
439843002133	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843002134	putative substrate translocation pore; other site
439843002135	iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957
439843002136	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
439843002137	siderophore binding site; other site
439843002138	isochorismate synthase EntC; Provisional; Region: PRK15016
439843002139	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
439843002140	enterobactin synthase subunit E; Provisional; Region: entE; PRK10946
439843002141	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
439843002142	acyl-activating enzyme (AAE) consensus motif; other site
439843002143	active site
439843002144	AMP binding site [chemical binding]; other site
439843002145	substrate binding site [chemical binding]; other site
439843002146	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
439843002147	hydrophobic substrate binding pocket; other site
439843002148	Isochorismatase family; Region: Isochorismatase; pfam00857
439843002149	active site
439843002150	conserved cis-peptide bond; other site
439843002151	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
439843002152	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
439843002153	2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331
439843002154	putative NAD(P) binding site [chemical binding]; other site
439843002155	active site
439843002156	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
439843002157	CoenzymeA binding site [chemical binding]; other site
439843002158	subunit interaction site [polypeptide binding]; other site
439843002159	PHB binding site; other site
439843002160	carbon starvation protein A; Provisional; Region: PRK15015
439843002161	Carbon starvation protein CstA; Region: CstA; pfam02554
439843002162	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
439843002163	Uncharacterized small protein [Function unknown]; Region: COG2879
439843002164	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
439843002165	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
439843002166	putative active site [active]
439843002167	metal binding site [ion binding]; metal-binding site
439843002168	methionine aminotransferase; Validated; Region: PRK09082
439843002169	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
439843002170	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843002171	homodimer interface [polypeptide binding]; other site
439843002172	catalytic residue [active]
439843002173	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
439843002174	ParB-like nuclease domain; Region: ParBc; pfam02195
439843002175	Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969
439843002176	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
439843002177	Active Sites [active]
439843002178	Domain of unknown function (DUF3440); Region: DUF3440; pfam11922
439843002179	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482
439843002180	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843002181	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
439843002182	dimerization interface [polypeptide binding]; other site
439843002183	disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657
439843002184	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
439843002185	dimerization domain [polypeptide binding]; other site
439843002186	dimer interface [polypeptide binding]; other site
439843002187	catalytic residues [active]
439843002188	alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382
439843002189	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
439843002190	dimer interface [polypeptide binding]; other site
439843002191	decamer (pentamer of dimers) interface [polypeptide binding]; other site
439843002192	catalytic triad [active]
439843002193	peroxidatic and resolving cysteines [active]
439843002194	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
439843002195	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
439843002196	catalytic residue [active]
439843002197	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
439843002198	catalytic residues [active]
439843002199	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
439843002200	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
439843002201	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
439843002202	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
439843002203	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
439843002204	putative [4Fe-4S] binding site [ion binding]; other site
439843002205	putative molybdopterin cofactor binding site [chemical binding]; other site
439843002206	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775
439843002207	molybdopterin cofactor binding site; other site
439843002208	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
439843002209	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
439843002210	DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302
439843002211	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
439843002212	Ligand Binding Site [chemical binding]; other site
439843002213	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
439843002214	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
439843002215	NAD binding site [chemical binding]; other site
439843002216	catalytic Zn binding site [ion binding]; other site
439843002217	structural Zn binding site [ion binding]; other site
439843002218	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
439843002219	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
439843002220	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
439843002221	B1 nucleotide binding pocket [chemical binding]; other site
439843002222	B2 nucleotide binding pocket [chemical binding]; other site
439843002223	CAS motifs; other site
439843002224	active site
439843002225	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
439843002226	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
439843002227	transmembrane helices; other site
439843002228	triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096
439843002229	Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697
439843002230	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
439843002231	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
439843002232	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
439843002233	Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052
439843002234	Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053
439843002235	Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169
439843002236	putative active site [active]
439843002237	(T/H)XGH motif; other site
439843002238	sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053
439843002239	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
439843002240	putative active site [active]
439843002241	heme pocket [chemical binding]; other site
439843002242	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439843002243	ATP binding site [chemical binding]; other site
439843002244	Mg2+ binding site [ion binding]; other site
439843002245	G-X-G motif; other site
439843002246	two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046
439843002247	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843002248	active site
439843002249	phosphorylation site [posttranslational modification]
439843002250	intermolecular recognition site; other site
439843002251	dimerization interface [polypeptide binding]; other site
439843002252	Transcriptional regulator; Region: CitT; pfam12431
439843002253	C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654
439843002254	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
439843002255	phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045
439843002256	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
439843002257	DNA-binding site [nucleotide binding]; DNA binding site
439843002258	RNA-binding motif; other site
439843002259	chromosome condensation membrane protein; Provisional; Region: PRK14196
439843002260	Predicted amidohydrolase [General function prediction only]; Region: COG0388
439843002261	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
439843002262	putative active site [active]
439843002263	catalytic triad [active]
439843002264	putative dimer interface [polypeptide binding]; other site
439843002265	twin arginine translocase protein E; Validated; Region: tatE; PRK03625
439843002266	lipoyl synthase; Provisional; Region: PRK05481
439843002267	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439843002268	FeS/SAM binding site; other site
439843002269	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482
439843002270	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843002271	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
439843002272	substrate binding pocket [chemical binding]; other site
439843002273	dimerization interface [polypeptide binding]; other site
439843002274	lipoate-protein ligase B; Provisional; Region: PRK14342
439843002275	hypothetical protein; Provisional; Region: PRK04998
439843002276	D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793
439843002277	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
439843002278	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
439843002279	rare lipoprotein A; Provisional; Region: PRK10672
439843002280	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
439843002281	Sporulation related domain; Region: SPOR; pfam05036
439843002282	cell wall shape-determining protein; Provisional; Region: PRK10794
439843002283	penicillin-binding protein 2; Provisional; Region: PRK10795
439843002284	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
439843002285	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
439843002286	rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246
439843002287	ribosome-associated protein; Provisional; Region: PRK11538
439843002288	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
439843002289	catalytic core [active]
439843002290	threonine-phosphate decarboxylase; Provisional; Region: PRK08056
439843002291	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
439843002292	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843002293	homodimer interface [polypeptide binding]; other site
439843002294	catalytic residue [active]
439843002295	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
439843002296	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
439843002297	active site
439843002298	(T/H)XGH motif; other site
439843002299	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
439843002300	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
439843002301	LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796
439843002302	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
439843002303	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
439843002304	HIGH motif; other site
439843002305	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
439843002306	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
439843002307	active site
439843002308	KMSKS motif; other site
439843002309	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
439843002310	tRNA binding surface [nucleotide binding]; other site
439843002311	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
439843002312	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
439843002313	2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274
439843002314	Propionate catabolism activator; Region: PrpR_N; pfam06506
439843002315	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
439843002316	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439843002317	Walker A motif; other site
439843002318	ATP binding site [chemical binding]; other site
439843002319	Walker B motif; other site
439843002320	arginine finger; other site
439843002321	hypothetical protein; Provisional; Region: PRK11032
439843002322	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
439843002323	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
439843002324	active site
439843002325	tetramer interface [polypeptide binding]; other site
439843002326	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
439843002327	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
439843002328	Walker A/P-loop; other site
439843002329	ATP binding site [chemical binding]; other site
439843002330	Q-loop/lid; other site
439843002331	ABC transporter signature motif; other site
439843002332	Walker B; other site
439843002333	D-loop; other site
439843002334	H-loop/switch region; other site
439843002335	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
439843002336	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843002337	dimer interface [polypeptide binding]; other site
439843002338	conserved gate region; other site
439843002339	putative PBP binding loops; other site
439843002340	ABC-ATPase subunit interface; other site
439843002341	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
439843002342	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843002343	dimer interface [polypeptide binding]; other site
439843002344	conserved gate region; other site
439843002345	putative PBP binding loops; other site
439843002346	ABC-ATPase subunit interface; other site
439843002347	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
439843002348	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
439843002349	substrate binding pocket [chemical binding]; other site
439843002350	membrane-bound complex binding site; other site
439843002351	hinge residues; other site
439843002352	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
439843002353	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
439843002354	putative active site [active]
439843002355	catalytic triad [active]
439843002356	putative dimer interface [polypeptide binding]; other site
439843002357	magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094
439843002358	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
439843002359	Transporter associated domain; Region: CorC_HlyC; smart01091
439843002360	metal-binding heat shock protein; Provisional; Region: PRK00016
439843002361	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
439843002362	PhoH-like protein; Region: PhoH; pfam02562
439843002363	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
439843002364	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
439843002365	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439843002366	FeS/SAM binding site; other site
439843002367	TRAM domain; Region: TRAM; pfam01938
439843002368	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020
439843002369	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
439843002370	Integrase core domain; Region: rve; pfam00665
439843002371	Integrase core domain; Region: rve_3; pfam13683
439843002372	Homeodomain-like domain; Region: HTH_23; cl17451
439843002373	asparagine synthetase B; Provisional; Region: asnB; PRK09431
439843002374	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
439843002375	active site
439843002376	dimer interface [polypeptide binding]; other site
439843002377	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
439843002378	Ligand Binding Site [chemical binding]; other site
439843002379	Molecular Tunnel; other site
439843002380	UMP phosphatase; Provisional; Region: PRK10444
439843002381	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439843002382	active site
439843002383	motif I; other site
439843002384	motif II; other site
439843002385	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439843002386	MarR family; Region: MarR; pfam01047
439843002387	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
439843002388	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
439843002389	nucleotide binding site [chemical binding]; other site
439843002390	N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221
439843002391	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
439843002392	active site
439843002393	dimer interface [polypeptide binding]; other site
439843002394	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
439843002395	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
439843002396	active site
439843002397	trimer interface [polypeptide binding]; other site
439843002398	allosteric site; other site
439843002399	active site lid [active]
439843002400	hexamer (dimer of trimers) interface [polypeptide binding]; other site
439843002401	PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255
439843002402	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
439843002403	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
439843002404	active site turn [active]
439843002405	phosphorylation site [posttranslational modification]
439843002406	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
439843002407	HPr interaction site; other site
439843002408	glycerol kinase (GK) interaction site [polypeptide binding]; other site
439843002409	active site
439843002410	phosphorylation site [posttranslational modification]
439843002411	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
439843002412	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
439843002413	active site
439843002414	HIGH motif; other site
439843002415	nucleotide binding site [chemical binding]; other site
439843002416	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
439843002417	KMSKS motif; other site
439843002418	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
439843002419	outer membrane porin, OprD family; Region: OprD; pfam03573
439843002420	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
439843002421	YbfN-like lipoprotein; Region: YbfN; pfam13982
439843002422	citrate-proton symporter; Provisional; Region: PRK15075
439843002423	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843002424	putative substrate translocation pore; other site
439843002425	tricarballylate utilization protein B; Provisional; Region: PRK15033
439843002426	tricarballylate dehydrogenase; Validated; Region: PRK08274
439843002427	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
439843002428	Transcriptional regulator [Transcription]; Region: LysR; COG0583
439843002429	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843002430	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
439843002431	putative dimerization interface [polypeptide binding]; other site
439843002432	ferric uptake regulator; Provisional; Region: fur; PRK09462
439843002433	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
439843002434	metal binding site 2 [ion binding]; metal-binding site
439843002435	putative DNA binding helix; other site
439843002436	metal binding site 1 [ion binding]; metal-binding site
439843002437	dimer interface [polypeptide binding]; other site
439843002438	structural Zn2+ binding site [ion binding]; other site
439843002439	flavodoxin FldA; Validated; Region: PRK09267
439843002440	LexA regulated protein; Provisional; Region: PRK11675
439843002441	acyl-CoA esterase; Provisional; Region: PRK10673
439843002442	PGAP1-like protein; Region: PGAP1; pfam07819
439843002443	replication initiation regulator SeqA; Provisional; Region: PRK11187
439843002444	phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132
439843002445	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
439843002446	active site
439843002447	substrate binding site [chemical binding]; other site
439843002448	metal binding site [ion binding]; metal-binding site
439843002449	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
439843002450	putrescine transporter; Provisional; Region: potE; PRK10655
439843002451	ornithine decarboxylase; Provisional; Region: PRK13578
439843002452	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
439843002453	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
439843002454	homodimer interface [polypeptide binding]; other site
439843002455	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843002456	catalytic residue [active]
439843002457	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
439843002458	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
439843002459	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843002460	active site
439843002461	phosphorylation site [posttranslational modification]
439843002462	intermolecular recognition site; other site
439843002463	dimerization interface [polypeptide binding]; other site
439843002464	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
439843002465	DNA binding site [nucleotide binding]
439843002466	sensor protein KdpD; Provisional; Region: PRK10490
439843002467	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
439843002468	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
439843002469	Ligand Binding Site [chemical binding]; other site
439843002470	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
439843002471	GAF domain; Region: GAF_3; pfam13492
439843002472	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439843002473	dimer interface [polypeptide binding]; other site
439843002474	phosphorylation site [posttranslational modification]
439843002475	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439843002476	ATP binding site [chemical binding]; other site
439843002477	Mg2+ binding site [ion binding]; other site
439843002478	G-X-G motif; other site
439843002479	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
439843002480	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
439843002481	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
439843002482	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
439843002483	Protein of unknown function (DUF2517); Region: DUF2517; pfam10725
439843002484	deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674
439843002485	DNA photolyase; Region: DNA_photolyase; pfam00875
439843002486	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
439843002487	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843002488	putative substrate translocation pore; other site
439843002489	POT family; Region: PTR2; pfam00854
439843002490	Uncharacterized conserved protein [Function unknown]; Region: COG0327
439843002491	metal-binding protein; Provisional; Region: PRK10799
439843002492	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
439843002493	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
439843002494	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
439843002495	Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800
439843002496	putative active site [active]
439843002497	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
439843002498	active site
439843002499	DNA binding site [nucleotide binding]
439843002500	Int/Topo IB signature motif; other site
439843002501	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
439843002502	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
439843002503	UDP-galactopyranose mutase; Region: GLF; pfam03275
439843002504	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
439843002505	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
439843002506	active site
439843002507	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
439843002508	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
439843002509	putative ADP-binding pocket [chemical binding]; other site
439843002510	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
439843002511	ABC-2 type transporter; Region: ABC2_membrane; cl17235
439843002512	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
439843002513	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
439843002514	Walker A/P-loop; other site
439843002515	ATP binding site [chemical binding]; other site
439843002516	Q-loop/lid; other site
439843002517	ABC transporter signature motif; other site
439843002518	Walker B; other site
439843002519	D-loop; other site
439843002520	H-loop/switch region; other site
439843002521	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
439843002522	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
439843002523	active site
439843002524	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
439843002525	active site
439843002526	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
439843002527	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610
439843002528	endonuclease VIII; Provisional; Region: PRK10445
439843002529	N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965
439843002530	DNA binding site [nucleotide binding]
439843002531	catalytic residue [active]
439843002532	putative catalytic residues [active]
439843002533	H2TH interface [polypeptide binding]; other site
439843002534	intercalation triad [nucleotide binding]; other site
439843002535	substrate specificity determining residue; other site
439843002536	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
439843002537	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
439843002538	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
439843002539	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
439843002540	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
439843002541	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
439843002542	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
439843002543	dimer interface [polypeptide binding]; other site
439843002544	active site
439843002545	citrylCoA binding site [chemical binding]; other site
439843002546	NADH binding [chemical binding]; other site
439843002547	cationic pore residues; other site
439843002548	oxalacetate/citrate binding site [chemical binding]; other site
439843002549	coenzyme A binding site [chemical binding]; other site
439843002550	catalytic triad [active]
439843002551	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
439843002552	Iron-sulfur protein interface; other site
439843002553	proximal quinone binding site [chemical binding]; other site
439843002554	SdhD (CybS) interface [polypeptide binding]; other site
439843002555	proximal heme binding site [chemical binding]; other site
439843002556	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
439843002557	SdhC subunit interface [polypeptide binding]; other site
439843002558	proximal heme binding site [chemical binding]; other site
439843002559	cardiolipin binding site; other site
439843002560	Iron-sulfur protein interface; other site
439843002561	proximal quinone binding site [chemical binding]; other site
439843002562	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958
439843002563	L-aspartate oxidase; Provisional; Region: PRK06175
439843002564	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
439843002565	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
439843002566	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
439843002567	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
439843002568	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
439843002569	TPP-binding site [chemical binding]; other site
439843002570	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
439843002571	dimer interface [polypeptide binding]; other site
439843002572	PYR/PP interface [polypeptide binding]; other site
439843002573	TPP binding site [chemical binding]; other site
439843002574	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
439843002575	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
439843002576	E3 interaction surface; other site
439843002577	lipoyl attachment site [posttranslational modification]; other site
439843002578	e3 binding domain; Region: E3_binding; pfam02817
439843002579	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
439843002580	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
439843002581	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
439843002582	CoA-ligase; Region: Ligase_CoA; pfam00549
439843002583	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
439843002584	CoA binding domain; Region: CoA_binding; smart00881
439843002585	CoA-ligase; Region: Ligase_CoA; pfam00549
439843002586	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
439843002587	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
439843002588	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003
439843002589	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
439843002590	Predicted outer membrane lipoprotein [Function unknown]; Region: COG4890
439843002591	hypothetical protein; Provisional; Region: PRK10588
439843002592	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
439843002593	active site
439843002594	colicin uptake protein TolQ; Provisional; Region: PRK10801
439843002595	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
439843002596	colicin uptake protein TolR; Provisional; Region: PRK11024
439843002597	translocation protein TolB; Provisional; Region: tolB; PRK03629
439843002598	TolB amino-terminal domain; Region: TolB_N; pfam04052
439843002599	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
439843002600	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
439843002601	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
439843002602	peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802
439843002603	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
439843002604	ligand binding site [chemical binding]; other site
439843002605	tol-pal system protein YbgF; Provisional; Region: PRK10803
439843002606	Tetratricopeptide repeat; Region: TPR_6; pfam13174
439843002607	Tetratricopeptide repeat; Region: TPR_6; pfam13174
439843002608	quinolinate synthetase; Provisional; Region: PRK09375
439843002609	nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397
439843002610	zinc transporter ZitB; Provisional; Region: PRK03557
439843002611	YbgS-like protein; Region: YbgS; pfam13985
439843002612	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
439843002613	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
439843002614	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
439843002615	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
439843002616	dimer interface [polypeptide binding]; other site
439843002617	putative PBP binding regions; other site
439843002618	ABC-ATPase subunit  interface; other site
439843002619	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
439843002620	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
439843002621	Walker A/P-loop; other site
439843002622	ATP binding site [chemical binding]; other site
439843002623	Q-loop/lid; other site
439843002624	ABC transporter signature motif; other site
439843002625	Walker B; other site
439843002626	D-loop; other site
439843002627	H-loop/switch region; other site
439843002628	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
439843002629	catalytic core [active]
439843002630	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
439843002631	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
439843002632	active site
439843002633	catalytic residues [active]
439843002634	galactokinase; Provisional; Region: PRK05101
439843002635	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
439843002636	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
439843002637	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
439843002638	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
439843002639	dimer interface [polypeptide binding]; other site
439843002640	active site
439843002641	UDP-galactose-4-epimerase; Provisional; Region: PRK10675
439843002642	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
439843002643	NAD binding site [chemical binding]; other site
439843002644	homodimer interface [polypeptide binding]; other site
439843002645	active site
439843002646	substrate binding site [chemical binding]; other site
439843002647	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4714
439843002648	putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938
439843002649	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439843002650	Walker A/P-loop; other site
439843002651	ATP binding site [chemical binding]; other site
439843002652	Q-loop/lid; other site
439843002653	ABC transporter signature motif; other site
439843002654	Walker B; other site
439843002655	D-loop; other site
439843002656	H-loop/switch region; other site
439843002657	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439843002658	Walker A/P-loop; other site
439843002659	ATP binding site [chemical binding]; other site
439843002660	Q-loop/lid; other site
439843002661	ABC transporter signature motif; other site
439843002662	Walker B; other site
439843002663	D-loop; other site
439843002664	H-loop/switch region; other site
439843002665	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
439843002666	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
439843002667	molybdenum-pterin binding domain; Region: Mop; TIGR00638
439843002668	TOBE domain; Region: TOBE; pfam03459
439843002669	Protein of unknown function (DUF2592); Region: DUF2592; pfam10766
439843002670	molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677
439843002671	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
439843002672	substrate binding pocket [chemical binding]; other site
439843002673	membrane-bound complex binding site; other site
439843002674	hinge residues; other site
439843002675	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
439843002676	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843002677	dimer interface [polypeptide binding]; other site
439843002678	conserved gate region; other site
439843002679	putative PBP binding loops; other site
439843002680	ABC-ATPase subunit interface; other site
439843002681	molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144
439843002682	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439843002683	Walker A/P-loop; other site
439843002684	ATP binding site [chemical binding]; other site
439843002685	Q-loop/lid; other site
439843002686	ABC transporter signature motif; other site
439843002687	Walker B; other site
439843002688	D-loop; other site
439843002689	H-loop/switch region; other site
439843002690	molybdenum-pterin binding domain; Region: Mop; TIGR00638
439843002691	pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530
439843002692	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439843002693	active site
439843002694	motif I; other site
439843002695	motif II; other site
439843002696	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439843002697	6-phosphogluconolactonase; Provisional; Region: PRK11028
439843002698	acyl-CoA thioesterase; Provisional; Region: PRK10531
439843002699	putative pectinesterase; Region: PLN02432; cl01911
439843002700	imidazolonepropionase; Validated; Region: PRK09356
439843002701	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
439843002702	active site
439843002703	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
439843002704	putative active site [active]
439843002705	putative metal binding site [ion binding]; other site
439843002706	histidine utilization repressor; Provisional; Region: PRK14999
439843002707	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439843002708	DNA-binding site [nucleotide binding]; DNA binding site
439843002709	UTRA domain; Region: UTRA; pfam07702
439843002710	urocanate hydratase; Provisional; Region: PRK05414
439843002711	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
439843002712	active sites [active]
439843002713	tetramer interface [polypeptide binding]; other site
439843002714	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
439843002715	substrate binding site [chemical binding]; other site
439843002716	adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986
439843002717	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
439843002718	inhibitor-cofactor binding pocket; inhibition site
439843002719	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843002720	catalytic residue [active]
439843002721	biotin synthase; Provisional; Region: PRK15108
439843002722	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439843002723	FeS/SAM binding site; other site
439843002724	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
439843002725	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
439843002726	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
439843002727	substrate-cofactor binding pocket; other site
439843002728	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843002729	catalytic residue [active]
439843002730	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
439843002731	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439843002732	S-adenosylmethionine binding site [chemical binding]; other site
439843002733	AAA domain; Region: AAA_26; pfam13500
439843002734	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
439843002735	excinuclease ABC subunit B; Provisional; Region: PRK05298
439843002736	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
439843002737	ATP binding site [chemical binding]; other site
439843002738	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
439843002739	nucleotide binding region [chemical binding]; other site
439843002740	ATP-binding site [chemical binding]; other site
439843002741	Ultra-violet resistance protein B; Region: UvrB; pfam12344
439843002742	UvrB/uvrC motif; Region: UVR; pfam02151
439843002743	E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370
439843002744	pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372
439843002745	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
439843002746	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
439843002747	putative substrate binding pocket [chemical binding]; other site
439843002748	dimer interface [polypeptide binding]; other site
439843002749	phosphate binding site [ion binding]; other site
439843002750	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
439843002751	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439843002752	FeS/SAM binding site; other site
439843002753	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
439843002754	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
439843002755	MPT binding site; other site
439843002756	trimer interface [polypeptide binding]; other site
439843002757	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
439843002758	trimer interface [polypeptide binding]; other site
439843002759	dimer interface [polypeptide binding]; other site
439843002760	putative active site [active]
439843002761	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
439843002762	MoaE interaction surface [polypeptide binding]; other site
439843002763	MoeB interaction surface [polypeptide binding]; other site
439843002764	thiocarboxylated glycine; other site
439843002765	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
439843002766	MoaE homodimer interface [polypeptide binding]; other site
439843002767	MoaD interaction [polypeptide binding]; other site
439843002768	active site residues [active]
439843002769	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
439843002770	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
439843002771	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
439843002772	BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473
439843002773	Predicted integral membrane protein [Function unknown]; Region: COG0392
439843002774	cardiolipin synthase 2; Provisional; Region: PRK11263
439843002775	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
439843002776	putative active site [active]
439843002777	catalytic site [active]
439843002778	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
439843002779	putative active site [active]
439843002780	catalytic site [active]
439843002781	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
439843002782	putative catalytic site [active]
439843002783	putative metal binding site [ion binding]; other site
439843002784	putative phosphate binding site [ion binding]; other site
439843002785	Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076
439843002786	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
439843002787	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
439843002788	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
439843002789	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
439843002790	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
439843002791	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
439843002792	Walker A/P-loop; other site
439843002793	ATP binding site [chemical binding]; other site
439843002794	Q-loop/lid; other site
439843002795	ABC transporter signature motif; other site
439843002796	Walker B; other site
439843002797	D-loop; other site
439843002798	H-loop/switch region; other site
439843002799	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
439843002800	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
439843002801	Walker A/P-loop; other site
439843002802	ATP binding site [chemical binding]; other site
439843002803	Q-loop/lid; other site
439843002804	ABC transporter signature motif; other site
439843002805	Walker B; other site
439843002806	D-loop; other site
439843002807	H-loop/switch region; other site
439843002808	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
439843002809	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
439843002810	HlyD family secretion protein; Region: HlyD_3; pfam13437
439843002811	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552
439843002812	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
439843002813	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
439843002814	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
439843002815	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
439843002816	ATP binding site [chemical binding]; other site
439843002817	Mg++ binding site [ion binding]; other site
439843002818	motif III; other site
439843002819	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
439843002820	nucleotide binding region [chemical binding]; other site
439843002821	ATP-binding site [chemical binding]; other site
439843002822	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
439843002823	DEAD_2; Region: DEAD_2; pfam06733
439843002824	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
439843002825	glycosyl transferase family protein; Provisional; Region: PRK08136
439843002826	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
439843002827	hypothetical protein; Provisional; Region: PRK10259
439843002828	hypothetical protein; Provisional; Region: PRK11019
439843002829	23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727
439843002830	Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971
439843002831	putative mechanosensitive channel protein; Provisional; Region: PRK11465
439843002832	Mechanosensitive ion channel; Region: MS_channel; pfam00924
439843002833	glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493
439843002834	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
439843002835	Walker A/P-loop; other site
439843002836	ATP binding site [chemical binding]; other site
439843002837	Q-loop/lid; other site
439843002838	ABC transporter signature motif; other site
439843002839	Walker B; other site
439843002840	D-loop; other site
439843002841	H-loop/switch region; other site
439843002842	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
439843002843	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843002844	dimer interface [polypeptide binding]; other site
439843002845	conserved gate region; other site
439843002846	putative PBP binding loops; other site
439843002847	ABC-ATPase subunit interface; other site
439843002848	glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495
439843002849	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
439843002850	substrate binding pocket [chemical binding]; other site
439843002851	membrane-bound complex binding site; other site
439843002852	hinge residues; other site
439843002853	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
439843002854	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
439843002855	dimerization interface [polypeptide binding]; other site
439843002856	DPS ferroxidase diiron center [ion binding]; other site
439843002857	ion pore; other site
439843002858	threonine and homoserine efflux system; Provisional; Region: PRK10532
439843002859	EamA-like transporter family; Region: EamA; pfam00892
439843002860	outer membrane protein X; Provisional; Region: ompX; PRK09408
439843002861	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
439843002862	Sulfatase; Region: Sulfatase; pfam00884
439843002863	manganese transport regulator MntR; Provisional; Region: PRK11050
439843002864	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
439843002865	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
439843002866	L,D-transpeptidase; Provisional; Region: PRK10260
439843002867	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
439843002868	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
439843002869	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
439843002870	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439843002871	Walker A/P-loop; other site
439843002872	ATP binding site [chemical binding]; other site
439843002873	ABC transporter signature motif; other site
439843002874	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
439843002875	Walker B; other site
439843002876	ABC transporter; Region: ABC_tran_2; pfam12848
439843002877	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
439843002878	Protein of unknown function (DUF1479); Region: DUF1479; pfam07350
439843002879	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
439843002880	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439843002881	active site
439843002882	motif I; other site
439843002883	motif II; other site
439843002884	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439843002885	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
439843002886	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
439843002887	dimer interface [polypeptide binding]; other site
439843002888	active site
439843002889	glycine loop; other site
439843002890	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
439843002891	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439843002892	FeS/SAM binding site; other site
439843002893	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
439843002894	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
439843002895	ATP binding site [chemical binding]; other site
439843002896	substrate interface [chemical binding]; other site
439843002897	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
439843002898	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
439843002899	dimer interface [polypeptide binding]; other site
439843002900	putative functional site; other site
439843002901	putative MPT binding site; other site
439843002902	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
439843002903	catalytic nucleophile [active]
439843002904	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
439843002905	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
439843002906	Walker A/P-loop; other site
439843002907	ATP binding site [chemical binding]; other site
439843002908	Q-loop/lid; other site
439843002909	ABC transporter signature motif; other site
439843002910	Walker B; other site
439843002911	D-loop; other site
439843002912	H-loop/switch region; other site
439843002913	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
439843002914	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
439843002915	Walker A/P-loop; other site
439843002916	ATP binding site [chemical binding]; other site
439843002917	Q-loop/lid; other site
439843002918	ABC transporter signature motif; other site
439843002919	Walker B; other site
439843002920	D-loop; other site
439843002921	H-loop/switch region; other site
439843002922	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
439843002923	glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413
439843002924	The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499
439843002925	glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081
439843002926	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843002927	dimer interface [polypeptide binding]; other site
439843002928	conserved gate region; other site
439843002929	putative PBP binding loops; other site
439843002930	ABC-ATPase subunit interface; other site
439843002931	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
439843002932	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
439843002933	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843002934	dimer interface [polypeptide binding]; other site
439843002935	conserved gate region; other site
439843002936	putative PBP binding loops; other site
439843002937	ABC-ATPase subunit interface; other site
439843002938	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
439843002939	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
439843002940	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439843002941	FeS/SAM binding site; other site
439843002942	biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302
439843002943	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
439843002944	Ligand binding site [chemical binding]; other site
439843002945	Electron transfer flavoprotein domain; Region: ETF; pfam01012
439843002946	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
439843002947	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
439843002948	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
439843002949	Uncharacterized conserved protein [Function unknown]; Region: COG3777
439843002950	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
439843002951	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
439843002952	active site
439843002953	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
439843002954	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
439843002955	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
439843002956	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
439843002957	Transcriptional regulator [Transcription]; Region: LysR; COG0583
439843002958	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843002959	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
439843002960	putative dimerization interface [polypeptide binding]; other site
439843002961	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
439843002962	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
439843002963	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
439843002964	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
439843002965	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
439843002966	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
439843002967	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
439843002968	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
439843002969	putative C-terminal domain interface [polypeptide binding]; other site
439843002970	putative GSH binding site (G-site) [chemical binding]; other site
439843002971	putative dimer interface [polypeptide binding]; other site
439843002972	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
439843002973	putative N-terminal domain interface [polypeptide binding]; other site
439843002974	putative dimer interface [polypeptide binding]; other site
439843002975	putative substrate binding pocket (H-site) [chemical binding]; other site
439843002976	D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001
439843002977	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
439843002978	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
439843002979	DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681
439843002980	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
439843002981	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
439843002982	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
439843002983	PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385
439843002984	active site
439843002985	multidrug efflux system translocase MdfA; Provisional; Region: PRK15402
439843002986	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843002987	putative substrate translocation pore; other site
439843002988	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
439843002989	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439843002990	active site
439843002991	motif I; other site
439843002992	motif II; other site
439843002993	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439843002994	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843002995	putative substrate translocation pore; other site
439843002996	Major Facilitator Superfamily; Region: MFS_1; pfam07690
439843002997	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
439843002998	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
439843002999	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
439843003000	putative transporter; Provisional; Region: PRK04972
439843003001	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
439843003002	TrkA-C domain; Region: TrkA_C; pfam02080
439843003003	TrkA-C domain; Region: TrkA_C; pfam02080
439843003004	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
439843003005	Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045
439843003006	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
439843003007	GSH binding site [chemical binding]; other site
439843003008	catalytic residues [active]
439843003009	Protein of unknown function (DUF1418); Region: DUF1418; pfam07214
439843003010	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
439843003011	dimer interface [polypeptide binding]; other site
439843003012	FMN binding site [chemical binding]; other site
439843003013	NADPH bind site [chemical binding]; other site
439843003014	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
439843003015	RimK-like ATP-grasp domain; Region: RimK; pfam08443
439843003016	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
439843003017	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
439843003018	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
439843003019	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
439843003020	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439843003021	Walker A/P-loop; other site
439843003022	ATP binding site [chemical binding]; other site
439843003023	Q-loop/lid; other site
439843003024	ABC transporter signature motif; other site
439843003025	Walker B; other site
439843003026	D-loop; other site
439843003027	H-loop/switch region; other site
439843003028	TOBE domain; Region: TOBE_2; pfam08402
439843003029	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843003030	dimer interface [polypeptide binding]; other site
439843003031	conserved gate region; other site
439843003032	putative PBP binding loops; other site
439843003033	ABC-ATPase subunit interface; other site
439843003034	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
439843003035	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843003036	dimer interface [polypeptide binding]; other site
439843003037	conserved gate region; other site
439843003038	putative PBP binding loops; other site
439843003039	ABC-ATPase subunit interface; other site
439843003040	Protein of unknown function (DUF2593); Region: DUF2593; pfam10767
439843003041	23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085
439843003042	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439843003043	S-adenosylmethionine binding site [chemical binding]; other site
439843003044	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
439843003045	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
439843003046	active site
439843003047	P-loop; other site
439843003048	phosphorylation site [posttranslational modification]
439843003049	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
439843003050	Sulfatase; Region: Sulfatase; cl17466
439843003051	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
439843003052	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
439843003053	substrate binding pocket [chemical binding]; other site
439843003054	membrane-bound complex binding site; other site
439843003055	hinge residues; other site
439843003056	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843003057	dimer interface [polypeptide binding]; other site
439843003058	conserved gate region; other site
439843003059	putative PBP binding loops; other site
439843003060	ABC-ATPase subunit interface; other site
439843003061	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
439843003062	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843003063	dimer interface [polypeptide binding]; other site
439843003064	conserved gate region; other site
439843003065	putative PBP binding loops; other site
439843003066	ABC-ATPase subunit interface; other site
439843003067	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
439843003068	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
439843003069	substrate binding pocket [chemical binding]; other site
439843003070	membrane-bound complex binding site; other site
439843003071	hinge residues; other site
439843003072	arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124
439843003073	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439843003074	Walker A/P-loop; other site
439843003075	ATP binding site [chemical binding]; other site
439843003076	Q-loop/lid; other site
439843003077	ABC transporter signature motif; other site
439843003078	Walker B; other site
439843003079	D-loop; other site
439843003080	H-loop/switch region; other site
439843003081	putative lipoprotein; Provisional; Region: PRK10533
439843003082	hypothetical protein; Provisional; Region: PRK02877
439843003083	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
439843003084	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
439843003085	amidase catalytic site [active]
439843003086	Zn binding residues [ion binding]; other site
439843003087	substrate binding site [chemical binding]; other site
439843003088	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
439843003089	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
439843003090	NAD(P) binding site [chemical binding]; other site
439843003091	active site
439843003092	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
439843003093	atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245
439843003094	putative NAD(P) binding site [chemical binding]; other site
439843003095	putative active site [active]
439843003096	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
439843003097	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
439843003098	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
439843003099	tetramer interface [polypeptide binding]; other site
439843003100	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843003101	catalytic residue [active]
439843003102	pyruvate dehydrogenase; Provisional; Region: PRK09124
439843003103	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
439843003104	PYR/PP interface [polypeptide binding]; other site
439843003105	dimer interface [polypeptide binding]; other site
439843003106	tetramer interface [polypeptide binding]; other site
439843003107	TPP binding site [chemical binding]; other site
439843003108	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
439843003109	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
439843003110	TPP-binding site [chemical binding]; other site
439843003111	HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684
439843003112	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
439843003113	FAD binding pocket [chemical binding]; other site
439843003114	FAD binding motif [chemical binding]; other site
439843003115	phosphate binding motif [ion binding]; other site
439843003116	beta-alpha-beta structure motif; other site
439843003117	NAD binding pocket [chemical binding]; other site
439843003118	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
439843003119	catalytic loop [active]
439843003120	iron binding site [ion binding]; other site
439843003121	hybrid cluster protein; Provisional; Region: PRK05290
439843003122	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
439843003123	ACS interaction site; other site
439843003124	CODH interaction site; other site
439843003125	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
439843003126	hybrid metal cluster; other site
439843003127	Predicted membrane protein [Function unknown]; Region: COG2431
439843003128	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
439843003129	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
439843003130	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
439843003131	putative active site [active]
439843003132	putative metal-binding site [ion binding]; other site
439843003133	Protein of unknown function (DUF535); Region: DUF535; pfam04393
439843003134	macrolide transporter subunit MacA; Provisional; Region: PRK11578
439843003135	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
439843003136	HlyD family secretion protein; Region: HlyD_3; pfam13437
439843003137	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
439843003138	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
439843003139	Walker A/P-loop; other site
439843003140	ATP binding site [chemical binding]; other site
439843003141	Q-loop/lid; other site
439843003142	ABC transporter signature motif; other site
439843003143	Walker B; other site
439843003144	D-loop; other site
439843003145	H-loop/switch region; other site
439843003146	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
439843003147	FtsX-like permease family; Region: FtsX; pfam02687
439843003148	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
439843003149	DNA-binding site [nucleotide binding]; DNA binding site
439843003150	RNA-binding motif; other site
439843003151	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
439843003152	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
439843003153	Clp amino terminal domain; Region: Clp_N; pfam02861
439843003154	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439843003155	Walker A motif; other site
439843003156	ATP binding site [chemical binding]; other site
439843003157	Walker B motif; other site
439843003158	arginine finger; other site
439843003159	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439843003160	Walker A motif; other site
439843003161	ATP binding site [chemical binding]; other site
439843003162	Walker B motif; other site
439843003163	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
439843003164	Isochorismatase family; Region: Isochorismatase; pfam00857
439843003165	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
439843003166	catalytic triad [active]
439843003167	dimer interface [polypeptide binding]; other site
439843003168	conserved cis-peptide bond; other site
439843003169	Pirin-related protein [General function prediction only]; Region: COG1741
439843003170	Pirin; Region: Pirin; pfam02678
439843003171	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
439843003172	LysR family transcriptional regulator; Provisional; Region: PRK14997
439843003173	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843003174	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
439843003175	putative effector binding pocket; other site
439843003176	putative dimerization interface [polypeptide binding]; other site
439843003177	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
439843003178	rRNA binding site [nucleotide binding]; other site
439843003179	predicted 30S ribosome binding site; other site
439843003180	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
439843003181	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
439843003182	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
439843003183	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439843003184	Walker A/P-loop; other site
439843003185	ATP binding site [chemical binding]; other site
439843003186	Q-loop/lid; other site
439843003187	ABC transporter signature motif; other site
439843003188	Walker B; other site
439843003189	D-loop; other site
439843003190	H-loop/switch region; other site
439843003191	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
439843003192	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
439843003193	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439843003194	Walker A/P-loop; other site
439843003195	ATP binding site [chemical binding]; other site
439843003196	Q-loop/lid; other site
439843003197	ABC transporter signature motif; other site
439843003198	Walker B; other site
439843003199	D-loop; other site
439843003200	H-loop/switch region; other site
439843003201	thioredoxin reductase; Provisional; Region: PRK10262
439843003202	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
439843003203	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
439843003204	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
439843003205	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
439843003206	putative DNA binding site [nucleotide binding]; other site
439843003207	putative Zn2+ binding site [ion binding]; other site
439843003208	AsnC family; Region: AsnC_trans_reg; pfam01037
439843003209	DNA translocase FtsK; Provisional; Region: PRK10263
439843003210	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
439843003211	DNA translocase FtsK; Provisional; Region: PRK10263
439843003212	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
439843003213	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
439843003214	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
439843003215	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
439843003216	recombination factor protein RarA; Reviewed; Region: PRK13342
439843003217	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439843003218	Walker A motif; other site
439843003219	ATP binding site [chemical binding]; other site
439843003220	Walker B motif; other site
439843003221	arginine finger; other site
439843003222	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
439843003223	seryl-tRNA synthetase; Provisional; Region: PRK05431
439843003224	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
439843003225	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
439843003226	dimer interface [polypeptide binding]; other site
439843003227	active site
439843003228	motif 1; other site
439843003229	motif 2; other site
439843003230	motif 3; other site
439843003231	anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990
439843003232	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
439843003233	putative [Fe4-S4] binding site [ion binding]; other site
439843003234	putative molybdopterin cofactor binding site [chemical binding]; other site
439843003235	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
439843003236	putative molybdopterin cofactor binding site; other site
439843003237	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
439843003238	4Fe-4S binding domain; Region: Fer4; pfam00037
439843003239	DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976
439843003240	putative MFS family transporter protein; Provisional; Region: PRK03633
439843003241	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843003242	putative substrate translocation pore; other site
439843003243	inner membrane transporter YjeM; Provisional; Region: PRK15238
439843003244	pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145
439843003245	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439843003246	FeS/SAM binding site; other site
439843003247	pathogenicity island 1 protein SopD2; Provisional; Region: PRK15380
439843003248	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
439843003249	Pyruvate formate lyase 1; Region: PFL1; cd01678
439843003250	coenzyme A binding site [chemical binding]; other site
439843003251	active site
439843003252	catalytic residues [active]
439843003253	glycine loop; other site
439843003254	Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
439843003255	uncharacterized domain; Region: TIGR00702
439843003256	YcaO-like family; Region: YcaO; pfam02624
439843003257	Predicted membrane protein [Function unknown]; Region: COG2323
439843003258	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
439843003259	homodimer interface [polypeptide binding]; other site
439843003260	substrate-cofactor binding pocket; other site
439843003261	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843003262	catalytic residue [active]
439843003263	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
439843003264	Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554
439843003265	hinge; other site
439843003266	active site
439843003267	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
439843003268	cytidylate kinase; Provisional; Region: cmk; PRK00023
439843003269	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
439843003270	CMP-binding site; other site
439843003271	The sites determining sugar specificity; other site
439843003272	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
439843003273	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
439843003274	RNA binding site [nucleotide binding]; other site
439843003275	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
439843003276	RNA binding site [nucleotide binding]; other site
439843003277	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
439843003278	RNA binding site [nucleotide binding]; other site
439843003279	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
439843003280	RNA binding site [nucleotide binding]; other site
439843003281	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
439843003282	RNA binding site [nucleotide binding]; other site
439843003283	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
439843003284	IHF dimer interface [polypeptide binding]; other site
439843003285	IHF - DNA interface [nucleotide binding]; other site
439843003286	ComEC family competence protein; Provisional; Region: PRK11539
439843003287	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
439843003288	Competence protein; Region: Competence; pfam03772
439843003289	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
439843003290	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
439843003291	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
439843003292	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
439843003293	Walker A/P-loop; other site
439843003294	ATP binding site [chemical binding]; other site
439843003295	Q-loop/lid; other site
439843003296	ABC transporter signature motif; other site
439843003297	Walker B; other site
439843003298	D-loop; other site
439843003299	H-loop/switch region; other site
439843003300	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
439843003301	tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682
439843003302	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
439843003303	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
439843003304	hypothetical protein; Provisional; Region: PRK11827
439843003305	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
439843003306	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
439843003307	Ligand binding site; other site
439843003308	oligomer interface; other site
439843003309	hypothetical protein; Provisional; Region: PRK10593
439843003310	Uncharacterized conserved protein [Function unknown]; Region: COG1434
439843003311	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
439843003312	putative active site [active]
439843003313	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
439843003314	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439843003315	S-adenosylmethionine binding site [chemical binding]; other site
439843003316	condesin subunit F; Provisional; Region: PRK05260
439843003317	condesin subunit E; Provisional; Region: PRK05256
439843003318	Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096
439843003319	P-loop containing region of AAA domain; Region: AAA_29; cl17516
439843003320	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
439843003321	murein L,D-transpeptidase; Provisional; Region: PRK10594
439843003322	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
439843003323	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
439843003324	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
439843003325	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
439843003326	Peptidase M15; Region: Peptidase_M15_3; cl01194
439843003327	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
439843003328	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
439843003329	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
439843003330	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843003331	homodimer interface [polypeptide binding]; other site
439843003332	catalytic residue [active]
439843003333	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
439843003334	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
439843003335	trimer interface [polypeptide binding]; other site
439843003336	eyelet of channel; other site
439843003337	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
439843003338	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
439843003339	putative dimer interface [polypeptide binding]; other site
439843003340	putative anticodon binding site; other site
439843003341	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
439843003342	homodimer interface [polypeptide binding]; other site
439843003343	motif 1; other site
439843003344	motif 2; other site
439843003345	active site
439843003346	motif 3; other site
439843003347	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
439843003348	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
439843003349	active site
439843003350	aminopeptidase N; Provisional; Region: pepN; PRK14015
439843003351	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
439843003352	active site
439843003353	Zn binding site [ion binding]; other site
439843003354	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
439843003355	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
439843003356	quinone interaction residues [chemical binding]; other site
439843003357	active site
439843003358	catalytic residues [active]
439843003359	FMN binding site [chemical binding]; other site
439843003360	substrate binding site [chemical binding]; other site
439843003361	Protein of unknown function (DUF1379); Region: DUF1379; pfam07126
439843003362	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
439843003363	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
439843003364	MOSC domain; Region: MOSC; pfam03473
439843003365	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
439843003366	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
439843003367	catalytic loop [active]
439843003368	iron binding site [ion binding]; other site
439843003369	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
439843003370	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
439843003371	Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170
439843003372	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439843003373	S-adenosylmethionine binding site [chemical binding]; other site
439843003374	ABC transporter ATPase component; Reviewed; Region: PRK11147
439843003375	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439843003376	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439843003377	Walker A/P-loop; other site
439843003378	Walker A/P-loop; other site
439843003379	ATP binding site [chemical binding]; other site
439843003380	ATP binding site [chemical binding]; other site
439843003381	Q-loop/lid; other site
439843003382	Q-loop/lid; other site
439843003383	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
439843003384	ABC transporter signature motif; other site
439843003385	Walker B; other site
439843003386	D-loop; other site
439843003387	ABC transporter; Region: ABC_tran_2; pfam12848
439843003388	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
439843003389	paraquat-inducible membrane protein A; Provisional; Region: PRK15103
439843003390	Paraquat-inducible protein A; Region: PqiA; pfam04403
439843003391	Paraquat-inducible protein A; Region: PqiA; pfam04403
439843003392	paraquat-inducible protein B; Provisional; Region: PRK10807
439843003393	mce related protein; Region: MCE; pfam02470
439843003394	mce related protein; Region: MCE; pfam02470
439843003395	mce related protein; Region: MCE; pfam02470
439843003396	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
439843003397	Protein of unknown function (DUF330); Region: DUF330; pfam03886
439843003398	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
439843003399	active site 1 [active]
439843003400	dimer interface [polypeptide binding]; other site
439843003401	active site 2 [active]
439843003402	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
439843003403	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
439843003404	Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097
439843003405	outer membrane protein A; Reviewed; Region: PRK10808
439843003406	OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389
439843003407	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
439843003408	ligand binding site [chemical binding]; other site
439843003409	cell division inhibitor SulA; Region: sula; TIGR00623
439843003410	Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070
439843003411	TfoX C-terminal domain; Region: TfoX_C; pfam04994
439843003412	TIGR01666 family membrane protein; Region: YCCS
439843003413	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
439843003414	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
439843003415	Predicted membrane protein [Function unknown]; Region: COG3304
439843003416	Domain of unknown function (DUF307); Region: DUF307; pfam03733
439843003417	Domain of unknown function (DUF307); Region: DUF307; pfam03733
439843003418	DNA helicase IV; Provisional; Region: helD; PRK11054
439843003419	DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462
439843003420	Part of AAA domain; Region: AAA_19; pfam13245
439843003421	Family description; Region: UvrD_C_2; pfam13538
439843003422	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
439843003423	active site
439843003424	dimer interfaces [polypeptide binding]; other site
439843003425	catalytic residues [active]
439843003426	hypothetical protein; Provisional; Region: PRK03641
439843003427	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110
439843003428	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
439843003429	heat shock protein HspQ; Provisional; Region: PRK14129
439843003430	23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128
439843003431	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
439843003432	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
439843003433	putative RNA binding site [nucleotide binding]; other site
439843003434	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439843003435	S-adenosylmethionine binding site [chemical binding]; other site
439843003436	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
439843003437	substrate binding site [chemical binding]; other site
439843003438	Cupin domain; Region: Cupin_2; cl17218
439843003439	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
439843003440	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439843003441	acylphosphatase; Provisional; Region: PRK14426
439843003442	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
439843003443	sulfur transfer protein TusE; Provisional; Region: PRK11508
439843003444	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
439843003445	YccA-like proteins; Region: YccA_like; cd10433
439843003446	secreted effector protein PipB; Provisional; Region: PRK15197
439843003447	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
439843003448	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
439843003449	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
439843003450	type III secretion chaperone protein SigE; Provisional; Region: PRK15202
439843003451	inositol phosphate phosphatase SopB; Provisional; Region: PRK15378
439843003452	Enterobacterial virulence protein IpgD; Region: IpgD; pfam05925
439843003453	Domain of unknown function (DUF3950); Region: DUF3950; pfam13132
439843003454	Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690
439843003455	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
439843003456	HAMP domain; Region: HAMP; pfam00672
439843003457	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439843003458	dimer interface [polypeptide binding]; other site
439843003459	phosphorylation site [posttranslational modification]
439843003460	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439843003461	ATP binding site [chemical binding]; other site
439843003462	Mg2+ binding site [ion binding]; other site
439843003463	G-X-G motif; other site
439843003464	transcriptional regulatory protein YedW; Provisional; Region: PRK11517
439843003465	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843003466	active site
439843003467	phosphorylation site [posttranslational modification]
439843003468	intermolecular recognition site; other site
439843003469	dimerization interface [polypeptide binding]; other site
439843003470	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
439843003471	DNA binding site [nucleotide binding]
439843003472	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
439843003473	active site
439843003474	homotetramer interface [polypeptide binding]; other site
439843003475	4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486
439843003476	4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310
439843003477	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
439843003478	homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337
439843003479	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
439843003480	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203
439843003481	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
439843003482	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
439843003483	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299
439843003484	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
439843003485	NAD binding site [chemical binding]; other site
439843003486	catalytic residues [active]
439843003487	The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370
439843003488	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
439843003489	putative active site [active]
439843003490	putative metal binding site [ion binding]; other site
439843003491	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
439843003492	putative substrate binding pocket [chemical binding]; other site
439843003493	trimer interface [polypeptide binding]; other site
439843003494	2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312
439843003495	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
439843003496	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843003497	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
439843003498	putative substrate translocation pore; other site
439843003499	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
439843003500	Cupin domain; Region: Cupin_2; pfam07883
439843003501	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439843003502	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
439843003503	chaperone-modulator protein CbpM; Provisional; Region: PRK10265
439843003504	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
439843003505	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
439843003506	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
439843003507	HSP70 interaction site [polypeptide binding]; other site
439843003508	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
439843003509	substrate binding site [polypeptide binding]; other site
439843003510	dimer interface [polypeptide binding]; other site
439843003511	Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233
439843003512	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
439843003513	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
439843003514	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
439843003515	DsbD alpha interface [polypeptide binding]; other site
439843003516	catalytic residues [active]
439843003517	conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283
439843003518	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
439843003519	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
439843003520	catalytic residues [active]
439843003521	TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011
439843003522	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
439843003523	catalytic residues [active]
439843003524	glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173
439843003525	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
439843003526	catalytic core [active]
439843003527	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
439843003528	hypothetical protein; Provisional; Region: PRK10174
439843003529	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
439843003530	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
439843003531	HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008
439843003532	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
439843003533	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
439843003534	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755
439843003535	trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809
439843003536	Predicted transcriptional regulator [Transcription]; Region: COG3905
439843003537	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
439843003538	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
439843003539	Glutamate binding site [chemical binding]; other site
439843003540	NAD binding site [chemical binding]; other site
439843003541	catalytic residues [active]
439843003542	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
439843003543	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
439843003544	Na binding site [ion binding]; other site
439843003545	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
439843003546	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
439843003547	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
439843003548	putative active site [active]
439843003549	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495
439843003550	Na binding site [ion binding]; other site
439843003551	Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010
439843003552	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
439843003553	putative active site cavity [active]
439843003554	N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131
439843003555	Galactose oxidase, central domain; Region: Kelch_3; pfam13415
439843003556	Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178
439843003557	putative sialic acid transporter; Provisional; Region: PRK12307
439843003558	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843003559	putative substrate translocation pore; other site
439843003560	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
439843003561	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
439843003562	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
439843003563	bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469
439843003564	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
439843003565	putative ligand binding site [chemical binding]; other site
439843003566	NAD binding site [chemical binding]; other site
439843003567	dimerization interface [polypeptide binding]; other site
439843003568	catalytic site [active]
439843003569	putative hydrolase; Validated; Region: PRK09248
439843003570	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
439843003571	active site
439843003572	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
439843003573	Protein of unknown function (DUF1097); Region: DUF1097; pfam06496
439843003574	curli production assembly/transport protein CsgG; Provisional; Region: PRK15184
439843003575	curli assembly protein CsgF; Provisional; Region: PRK10050
439843003576	curli assembly protein CsgE; Provisional; Region: PRK10386
439843003577	DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100
439843003578	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
439843003579	DNA binding residues [nucleotide binding]
439843003580	dimerization interface [polypeptide binding]; other site
439843003581	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
439843003582	Curlin associated repeat; Region: Curlin_rpt; pfam07012
439843003583	Curlin associated repeat; Region: Curlin_rpt; pfam07012
439843003584	major curlin subunit; Provisional; Region: csgA; PRK10051
439843003585	Curlin associated repeat; Region: Curlin_rpt; pfam07012
439843003586	curli assembly protein CsgC; Provisional; Region: csgC; PRK10102
439843003587	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
439843003588	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
439843003589	putative ADP-ribose binding site [chemical binding]; other site
439843003590	putative active site [active]
439843003591	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
439843003592	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
439843003593	putative active site [active]
439843003594	catalytic site [active]
439843003595	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
439843003596	putative active site [active]
439843003597	catalytic site [active]
439843003598	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
439843003599	Acyltransferase family; Region: Acyl_transf_3; pfam01757
439843003600	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
439843003601	Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349
439843003602	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
439843003603	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
439843003604	Ligand binding site; other site
439843003605	DXD motif; other site
439843003606	lipoprotein; Provisional; Region: PRK10175
439843003607	secY/secA suppressor protein; Provisional; Region: PRK11467
439843003608	drug efflux system protein MdtG; Provisional; Region: PRK09874
439843003609	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843003610	putative substrate translocation pore; other site
439843003611	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
439843003612	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
439843003613	putative acyl-acceptor binding pocket; other site
439843003614	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
439843003615	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
439843003616	active site residue [active]
439843003617	hypothetical protein; Provisional; Region: PRK03757
439843003618	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
439843003619	Protein of unknown function (DUF2770); Region: DUF2770; pfam10968
439843003620	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
439843003621	hydroxyglutarate oxidase; Provisional; Region: PRK11728
439843003622	biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301
439843003623	DNA damage-inducible protein I; Provisional; Region: PRK10597
439843003624	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
439843003625	active site
439843003626	substrate binding pocket [chemical binding]; other site
439843003627	dimer interface [polypeptide binding]; other site
439843003628	lipoprotein; Provisional; Region: PRK10598
439843003629	glutaredoxin 2; Provisional; Region: PRK10387
439843003630	GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037
439843003631	C-terminal domain interface [polypeptide binding]; other site
439843003632	GSH binding site (G-site) [chemical binding]; other site
439843003633	catalytic residues [active]
439843003634	putative dimer interface [polypeptide binding]; other site
439843003635	C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199
439843003636	N-terminal domain interface [polypeptide binding]; other site
439843003637	multidrug resistance protein MdtH; Provisional; Region: PRK11646
439843003638	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843003639	putative substrate translocation pore; other site
439843003640	ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809
439843003641	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
439843003642	hypothetical protein; Provisional; Region: PRK11239
439843003643	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132
439843003644	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
439843003645	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
439843003646	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
439843003647	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
439843003648	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
439843003649	flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459
439843003650	anti-sigma28 factor FlgM; Provisional; Region: PRK10810
439843003651	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018
439843003652	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
439843003653	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
439843003654	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
439843003655	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
439843003656	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
439843003657	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
439843003658	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
439843003659	Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843
439843003660	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
439843003661	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
439843003662	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
439843003663	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
439843003664	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
439843003665	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
439843003666	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787
439843003667	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
439843003668	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
439843003669	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
439843003670	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
439843003671	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
439843003672	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
439843003673	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
439843003674	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
439843003675	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
439843003676	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
439843003677	Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951
439843003678	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
439843003679	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147
439843003680	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
439843003681	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027
439843003682	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
439843003683	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
439843003684	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
439843003685	homodimer interface [polypeptide binding]; other site
439843003686	oligonucleotide binding site [chemical binding]; other site
439843003687	Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111
439843003688	RNase E 5' UTR element
439843003689	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
439843003690	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
439843003691	RNA binding surface [nucleotide binding]; other site
439843003692	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
439843003693	active site
439843003694	Protein of unknown function (DUF3053); Region: DUF3053; pfam11254
439843003695	Maf-like protein; Region: Maf; pfam02545
439843003696	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
439843003697	active site
439843003698	dimer interface [polypeptide binding]; other site
439843003699	hypothetical protein; Provisional; Region: PRK11193
439843003700	putative phosphate acyltransferase; Provisional; Region: PRK05331
439843003701	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
439843003702	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
439843003703	dimer interface [polypeptide binding]; other site
439843003704	active site
439843003705	CoA binding pocket [chemical binding]; other site
439843003706	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
439843003707	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
439843003708	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
439843003709	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
439843003710	NAD(P) binding site [chemical binding]; other site
439843003711	homotetramer interface [polypeptide binding]; other site
439843003712	homodimer interface [polypeptide binding]; other site
439843003713	active site
439843003714	acyl carrier protein; Provisional; Region: acpP; PRK00982
439843003715	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
439843003716	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
439843003717	dimer interface [polypeptide binding]; other site
439843003718	active site
439843003719	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
439843003720	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
439843003721	Fimbrial protein; Region: Fimbrial; pfam00419
439843003722	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
439843003723	PapC N-terminal domain; Region: PapC_N; pfam13954
439843003724	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
439843003725	PapC C-terminal domain; Region: PapC_C; pfam13953
439843003726	fimbrial assembly chaperone SthB; Provisional; Region: PRK15295
439843003727	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
439843003728	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
439843003729	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
439843003730	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
439843003731	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
439843003732	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843003733	catalytic residue [active]
439843003734	conserved hypothetical protein, YceG family; Region: TIGR00247
439843003735	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
439843003736	dimerization interface [polypeptide binding]; other site
439843003737	thymidylate kinase; Validated; Region: tmk; PRK00698
439843003738	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
439843003739	TMP-binding site; other site
439843003740	ATP-binding site [chemical binding]; other site
439843003741	DNA polymerase III subunit delta'; Validated; Region: PRK07993
439843003742	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
439843003743	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
439843003744	active site
439843003745	PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089
439843003746	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
439843003747	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
439843003748	active site turn [active]
439843003749	phosphorylation site [posttranslational modification]
439843003750	ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003
439843003751	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
439843003752	N-terminal plug; other site
439843003753	ligand-binding site [chemical binding]; other site
439843003754	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
439843003755	nucleotide binding site/active site [active]
439843003756	HIT family signature motif; other site
439843003757	catalytic residue [active]
439843003758	Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633
439843003759	Putative periplasmic lipoprotein; Region: DUF1425; cd09030
439843003760	putative dimer interface [polypeptide binding]; other site
439843003761	Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417
439843003762	thiamine kinase; Region: ycfN_thiK; TIGR02721
439843003763	thiamine kinase; Provisional; Region: thiK; PRK10271
439843003764	substrate binding site [chemical binding]; other site
439843003765	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
439843003766	beta-hexosaminidase; Provisional; Region: PRK05337
439843003767	hypothetical protein; Provisional; Region: PRK04940
439843003768	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
439843003769	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
439843003770	hypothetical protein; Provisional; Region: PRK11280
439843003771	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
439843003772	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
439843003773	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
439843003774	L,D-transpeptidase; Provisional; Region: PRK10190
439843003775	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
439843003776	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
439843003777	transcription-repair coupling factor; Provisional; Region: PRK10689
439843003778	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
439843003779	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
439843003780	ATP binding site [chemical binding]; other site
439843003781	putative Mg++ binding site [ion binding]; other site
439843003782	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
439843003783	nucleotide binding region [chemical binding]; other site
439843003784	ATP-binding site [chemical binding]; other site
439843003785	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
439843003786	outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814
439843003787	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
439843003788	FtsX-like permease family; Region: FtsX; pfam02687
439843003789	lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629
439843003790	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
439843003791	Walker A/P-loop; other site
439843003792	ATP binding site [chemical binding]; other site
439843003793	Q-loop/lid; other site
439843003794	ABC transporter signature motif; other site
439843003795	Walker B; other site
439843003796	D-loop; other site
439843003797	H-loop/switch region; other site
439843003798	outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146
439843003799	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
439843003800	FtsX-like permease family; Region: FtsX; pfam02687
439843003801	fructokinase; Reviewed; Region: PRK09557
439843003802	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
439843003803	nucleotide binding site [chemical binding]; other site
439843003804	NAD-dependent deacetylase; Provisional; Region: PRK00481
439843003805	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
439843003806	NAD+ binding site [chemical binding]; other site
439843003807	substrate binding site [chemical binding]; other site
439843003808	Zn binding site [ion binding]; other site
439843003809	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
439843003810	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
439843003811	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
439843003812	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843003813	dimer interface [polypeptide binding]; other site
439843003814	conserved gate region; other site
439843003815	putative PBP binding loops; other site
439843003816	ABC-ATPase subunit interface; other site
439843003817	secreted effector protein SifA; Reviewed; Region: sifA; PRK09498
439843003818	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
439843003819	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843003820	dimer interface [polypeptide binding]; other site
439843003821	conserved gate region; other site
439843003822	putative PBP binding loops; other site
439843003823	ABC-ATPase subunit interface; other site
439843003824	putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452
439843003825	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439843003826	Walker A/P-loop; other site
439843003827	ATP binding site [chemical binding]; other site
439843003828	Q-loop/lid; other site
439843003829	ABC transporter signature motif; other site
439843003830	Walker B; other site
439843003831	D-loop; other site
439843003832	H-loop/switch region; other site
439843003833	TOBE domain; Region: TOBE_2; pfam08402
439843003834	Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195
439843003835	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
439843003836	metal binding site [ion binding]; metal-binding site
439843003837	dimer interface [polypeptide binding]; other site
439843003838	Uncharacterized conserved protein [Function unknown]; Region: COG2850
439843003839	Cupin domain; Region: Cupin_2; cl17218
439843003840	sensor protein PhoQ; Provisional; Region: PRK10815
439843003841	PhoQ Sensor; Region: PhoQ_Sensor; pfam08918
439843003842	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
439843003843	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439843003844	ATP binding site [chemical binding]; other site
439843003845	Mg2+ binding site [ion binding]; other site
439843003846	G-X-G motif; other site
439843003847	DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816
439843003848	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843003849	active site
439843003850	phosphorylation site [posttranslational modification]
439843003851	intermolecular recognition site; other site
439843003852	dimerization interface [polypeptide binding]; other site
439843003853	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
439843003854	DNA binding site [nucleotide binding]
439843003855	adenylosuccinate lyase; Provisional; Region: PRK09285
439843003856	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
439843003857	tetramer interface [polypeptide binding]; other site
439843003858	active site
439843003859	putative lysogenization regulator; Reviewed; Region: PRK00218
439843003860	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
439843003861	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420
439843003862	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
439843003863	nudix motif; other site
439843003864	Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461
439843003865	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
439843003866	23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394
439843003867	Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566
439843003868	probable active site [active]
439843003869	isocitrate dehydrogenase; Validated; Region: PRK07362
439843003870	isocitrate dehydrogenase; Reviewed; Region: PRK07006
439843003871	Protein of unknown function (DUF3626); Region: DUF3626; pfam12294
439843003872	pertussis toxin-like subunit ArtA; Provisional; Region: PRK15272
439843003873	Lysozyme family protein [General function prediction only]; Region: zliS; COG3926
439843003874	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
439843003875	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
439843003876	Protein of unknown function (DUF1353); Region: DUF1353; pfam07087
439843003877	CdtB, the catalytic DNase I-like subunit of cytolethal distending toxin (CDT) protein; Region: CdtB; cd09081
439843003878	putative catalytic site [active]
439843003879	CdtC interface [polypeptide binding]; other site
439843003880	heterotrimer interface [polypeptide binding]; other site
439843003881	CdtA interface [polypeptide binding]; other site
439843003882	putative metal binding site [ion binding]; other site
439843003883	putative phosphate binding site [ion binding]; other site
439843003884	DinI-like family; Region: DinI; pfam06183
439843003885	Ricin-type beta-trefoil; Region: RICIN; smart00458
439843003886	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
439843003887	putative sugar binding sites [chemical binding]; other site
439843003888	Q-X-W motif; other site
439843003889	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
439843003890	DNA-binding site [nucleotide binding]; DNA binding site
439843003891	RNA-binding motif; other site
439843003892	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
439843003893	lysozyme inhibitor; Provisional; Region: PRK13791
439843003894	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
439843003895	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
439843003896	putative dimer interface [polypeptide binding]; other site
439843003897	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
439843003898	BNR repeat-like domain; Region: BNR_2; pfam13088
439843003899	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
439843003900	TRL-like protein family; Region: TRL; pfam13146
439843003901	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
439843003902	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518
439843003903	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
439843003904	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843003905	dimer interface [polypeptide binding]; other site
439843003906	conserved gate region; other site
439843003907	ABC-ATPase subunit interface; other site
439843003908	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
439843003909	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843003910	dimer interface [polypeptide binding]; other site
439843003911	conserved gate region; other site
439843003912	putative PBP binding loops; other site
439843003913	ABC-ATPase subunit interface; other site
439843003914	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
439843003915	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
439843003916	Walker A/P-loop; other site
439843003917	ATP binding site [chemical binding]; other site
439843003918	Q-loop/lid; other site
439843003919	ABC transporter signature motif; other site
439843003920	Walker B; other site
439843003921	D-loop; other site
439843003922	H-loop/switch region; other site
439843003923	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
439843003924	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439843003925	Walker A/P-loop; other site
439843003926	ATP binding site [chemical binding]; other site
439843003927	Q-loop/lid; other site
439843003928	ABC transporter signature motif; other site
439843003929	Walker B; other site
439843003930	D-loop; other site
439843003931	H-loop/switch region; other site
439843003932	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
439843003933	Mechanosensitive ion channel; Region: MS_channel; pfam00924
439843003934	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
439843003935	dimerization interface [polypeptide binding]; other site
439843003936	zinc/cadmium-binding protein; Provisional; Region: PRK10306
439843003937	aminoglycoside resistance protein; Provisional; Region: PRK13746
439843003938	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
439843003939	active site
439843003940	NTP binding site [chemical binding]; other site
439843003941	metal binding triad [ion binding]; metal-binding site
439843003942	antibiotic binding site [chemical binding]; other site
439843003943	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
439843003944	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
439843003945	DNA binding residues [nucleotide binding]
439843003946	transcriptional regulator MirA; Provisional; Region: PRK15043
439843003947	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
439843003948	DNA binding residues [nucleotide binding]
439843003949	dimer interface [polypeptide binding]; other site
439843003950	Pleckstrin homology-like domain; Region: PH-like; cl17171
439843003951	Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798
439843003952	chorismate mutase; Provisional; Region: PRK08055
439843003953	leucine export protein LeuE; Provisional; Region: PRK10958
439843003954	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
439843003955	Domain of unknown function (DUF1869); Region: DUF1869; pfam08956
439843003956	Phage Tail Collar Domain; Region: Collar; pfam07484
439843003957	hypothetical protein; Provisional; Region: PRK10457
439843003958	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
439843003959	murein hydrolase B; Provisional; Region: PRK10760; cl17906
439843003960	Domain of unknown function (DUF333); Region: DUF333; pfam03891
439843003961	Uncharacterized conserved protein [Function unknown]; Region: COG3189
439843003962	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
439843003963	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843003964	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
439843003965	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439843003966	Predicted membrane protein [Function unknown]; Region: COG2707
439843003967	YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function.  The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336
439843003968	putative deacylase active site [active]
439843003969	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
439843003970	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
439843003971	metal binding site [ion binding]; metal-binding site
439843003972	active site
439843003973	I-site; other site
439843003974	hypothetical protein; Provisional; Region: PRK05325
439843003975	PrkA family serine protein kinase; Provisional; Region: PRK15455
439843003976	AAA ATPase domain; Region: AAA_16; pfam13191
439843003977	Walker A motif; other site
439843003978	ATP binding site [chemical binding]; other site
439843003979	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
439843003980	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
439843003981	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
439843003982	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439843003983	FeS/SAM binding site; other site
439843003984	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
439843003985	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
439843003986	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
439843003987	active site
439843003988	catalytic tetrad [active]
439843003989	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
439843003990	active site
439843003991	phosphate binding residues; other site
439843003992	catalytic residues [active]
439843003993	glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425
439843003994	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
439843003995	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
439843003996	methionine sulfoxide reductase B; Provisional; Region: PRK00222
439843003997	SelR domain; Region: SelR; pfam01641
439843003998	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139
439843003999	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
439843004000	Isochorismatase family; Region: Isochorismatase; pfam00857
439843004001	catalytic triad [active]
439843004002	metal binding site [ion binding]; metal-binding site
439843004003	conserved cis-peptide bond; other site
439843004004	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
439843004005	active site
439843004006	homodimer interface [polypeptide binding]; other site
439843004007	protease 4; Provisional; Region: PRK10949
439843004008	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
439843004009	tandem repeat interface [polypeptide binding]; other site
439843004010	oligomer interface [polypeptide binding]; other site
439843004011	active site residues [active]
439843004012	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019
439843004013	tandem repeat interface [polypeptide binding]; other site
439843004014	oligomer interface [polypeptide binding]; other site
439843004015	active site residues [active]
439843004016	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
439843004017	putative FMN binding site [chemical binding]; other site
439843004018	selenophosphate synthetase; Provisional; Region: PRK00943
439843004019	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
439843004020	dimerization interface [polypeptide binding]; other site
439843004021	putative ATP binding site [chemical binding]; other site
439843004022	DNA topoisomerase III; Provisional; Region: PRK07726
439843004023	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
439843004024	active site
439843004025	putative interdomain interaction site [polypeptide binding]; other site
439843004026	putative metal-binding site [ion binding]; other site
439843004027	putative nucleotide binding site [chemical binding]; other site
439843004028	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
439843004029	domain I; other site
439843004030	DNA binding groove [nucleotide binding]
439843004031	phosphate binding site [ion binding]; other site
439843004032	domain II; other site
439843004033	domain III; other site
439843004034	nucleotide binding site [chemical binding]; other site
439843004035	catalytic site [active]
439843004036	domain IV; other site
439843004037	glutamate dehydrogenase; Provisional; Region: PRK09414
439843004038	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
439843004039	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
439843004040	NAD(P) binding site [chemical binding]; other site
439843004041	Protein of unknown function (DUF1496); Region: DUF1496; pfam07383
439843004042	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
439843004043	active site
439843004044	8-oxo-dGMP binding site [chemical binding]; other site
439843004045	nudix motif; other site
439843004046	metal binding site [ion binding]; metal-binding site
439843004047	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
439843004048	putative catalytic site [active]
439843004049	putative phosphate binding site [ion binding]; other site
439843004050	active site
439843004051	metal binding site A [ion binding]; metal-binding site
439843004052	DNA binding site [nucleotide binding]
439843004053	putative AP binding site [nucleotide binding]; other site
439843004054	putative metal binding site B [ion binding]; other site
439843004055	bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381
439843004056	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
439843004057	inhibitor-cofactor binding pocket; inhibition site
439843004058	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843004059	catalytic residue [active]
439843004060	arginine succinyltransferase; Provisional; Region: PRK10456
439843004061	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
439843004062	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
439843004063	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
439843004064	NAD(P) binding site [chemical binding]; other site
439843004065	catalytic residues [active]
439843004066	succinylarginine dihydrolase; Provisional; Region: PRK13281
439843004067	Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855
439843004068	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
439843004069	putative active site [active]
439843004070	Zn binding site [ion binding]; other site
439843004071	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
439843004072	dimer interface [polypeptide binding]; other site
439843004073	nucleotide excision repair endonuclease; Provisional; Region: PRK10545
439843004074	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
439843004075	GIY-YIG motif/motif A; other site
439843004076	active site
439843004077	catalytic site [active]
439843004078	putative DNA binding site [nucleotide binding]; other site
439843004079	metal binding site [ion binding]; metal-binding site
439843004080	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
439843004081	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
439843004082	homodimer interface [polypeptide binding]; other site
439843004083	NAD binding pocket [chemical binding]; other site
439843004084	ATP binding pocket [chemical binding]; other site
439843004085	Mg binding site [ion binding]; other site
439843004086	active-site loop [active]
439843004087	DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251
439843004088	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
439843004089	active site
439843004090	P-loop; other site
439843004091	phosphorylation site [posttranslational modification]
439843004092	PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297
439843004093	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
439843004094	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
439843004095	methionine cluster; other site
439843004096	active site
439843004097	phosphorylation site [posttranslational modification]
439843004098	metal binding site [ion binding]; metal-binding site
439843004099	DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296
439843004100	Cupin domain; Region: Cupin_2; pfam07883
439843004101	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439843004102	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
439843004103	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
439843004104	NAD binding site [chemical binding]; other site
439843004105	sugar binding site [chemical binding]; other site
439843004106	divalent metal binding site [ion binding]; other site
439843004107	tetramer (dimer of dimers) interface [polypeptide binding]; other site
439843004108	dimer interface [polypeptide binding]; other site
439843004109	Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803
439843004110	putative active site [active]
439843004111	YdjC motif; other site
439843004112	Mg binding site [ion binding]; other site
439843004113	putative homodimer interface [polypeptide binding]; other site
439843004114	hydroperoxidase II; Provisional; Region: katE; PRK11249
439843004115	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
439843004116	tetramer interface [polypeptide binding]; other site
439843004117	heme binding pocket [chemical binding]; other site
439843004118	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
439843004119	domain interactions; other site
439843004120	cell division modulator; Provisional; Region: PRK10113
439843004121	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
439843004122	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
439843004123	inner membrane protein; Provisional; Region: PRK11648
439843004124	2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826
439843004125	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
439843004126	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439843004127	motif II; other site
439843004128	YniB-like protein; Region: YniB; pfam14002
439843004129	Phosphotransferase enzyme family; Region: APH; pfam01636
439843004130	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
439843004131	active site
439843004132	ATP binding site [chemical binding]; other site
439843004133	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
439843004134	Protein of unknown function (DUF2622); Region: DUF2622; pfam11080
439843004135	6-phosphofructokinase 2; Provisional; Region: PRK10294
439843004136	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
439843004137	putative substrate binding site [chemical binding]; other site
439843004138	putative ATP binding site [chemical binding]; other site
439843004139	Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137
439843004140	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528
439843004141	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
439843004142	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
439843004143	active site
439843004144	substrate binding site [chemical binding]; other site
439843004145	Mg2+ binding site [ion binding]; other site
439843004146	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
439843004147	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
439843004148	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
439843004149	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
439843004150	active site
439843004151	dimer interface [polypeptide binding]; other site
439843004152	motif 1; other site
439843004153	motif 2; other site
439843004154	motif 3; other site
439843004155	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
439843004156	anticodon binding site; other site
439843004157	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
439843004158	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
439843004159	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
439843004160	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
439843004161	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
439843004162	23S rRNA binding site [nucleotide binding]; other site
439843004163	L21 binding site [polypeptide binding]; other site
439843004164	L13 binding site [polypeptide binding]; other site
439843004165	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
439843004166	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
439843004167	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
439843004168	dimer interface [polypeptide binding]; other site
439843004169	motif 1; other site
439843004170	active site
439843004171	motif 2; other site
439843004172	motif 3; other site
439843004173	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
439843004174	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
439843004175	putative tRNA-binding site [nucleotide binding]; other site
439843004176	B3/4 domain; Region: B3_4; pfam03483
439843004177	tRNA synthetase B5 domain; Region: B5; smart00874
439843004178	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
439843004179	dimer interface [polypeptide binding]; other site
439843004180	motif 1; other site
439843004181	motif 3; other site
439843004182	motif 2; other site
439843004183	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
439843004184	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
439843004185	IHF dimer interface [polypeptide binding]; other site
439843004186	IHF - DNA interface [nucleotide binding]; other site
439843004187	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
439843004188	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
439843004189	ABC-ATPase subunit  interface; other site
439843004190	dimer interface [polypeptide binding]; other site
439843004191	putative PBP binding regions; other site
439843004192	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
439843004193	catalytic residues [active]
439843004194	dimer interface [polypeptide binding]; other site
439843004195	vitamin B12-transporter ATPase; Provisional; Region: PRK03695
439843004196	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
439843004197	Walker A/P-loop; other site
439843004198	ATP binding site [chemical binding]; other site
439843004199	Q-loop/lid; other site
439843004200	ABC transporter signature motif; other site
439843004201	Walker B; other site
439843004202	D-loop; other site
439843004203	H-loop/switch region; other site
439843004204	NlpC/P60 family; Region: NLPC_P60; pfam00877
439843004205	c-di-GMP phosphodiesterase class I (EAL domain) [Signal    transduction mechanisms]; Region: Rtn; COG2200
439843004206	Uncharacterized conserved protein [Function unknown]; Region: COG0397
439843004207	hypothetical protein; Validated; Region: PRK00029
439843004208	hypothetical protein; Provisional; Region: PRK10183
439843004209	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756
439843004210	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
439843004211	PEP synthetase regulatory protein; Provisional; Region: PRK05339
439843004212	phosphoenolpyruvate synthase; Validated; Region: PRK06464
439843004213	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
439843004214	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
439843004215	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
439843004216	short chain acyl-CoA synthetase; Reviewed; Region: PRK06087
439843004217	Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903
439843004218	acyl-activating enzyme (AAE) consensus motif; other site
439843004219	putative AMP binding site [chemical binding]; other site
439843004220	putative active site [active]
439843004221	putative CoA binding site [chemical binding]; other site
439843004222	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
439843004223	oxidoreductase; Provisional; Region: PRK10015
439843004224	electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916
439843004225	Electron transfer flavoprotein domain; Region: ETF; smart00893
439843004226	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
439843004227	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
439843004228	Ligand binding site [chemical binding]; other site
439843004229	Electron transfer flavoprotein domain; Region: ETF; pfam01012
439843004230	Cupin domain; Region: Cupin_2; pfam07883
439843004231	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
439843004232	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439843004233	putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341
439843004234	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
439843004235	active site
439843004236	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
439843004237	Coenzyme A transferase; Region: CoA_trans; smart00882
439843004238	Coenzyme A transferase; Region: CoA_trans; cl17247
439843004239	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
439843004240	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
439843004241	active site
439843004242	catalytic residue [active]
439843004243	dimer interface [polypeptide binding]; other site
439843004244	quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749
439843004245	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
439843004246	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
439843004247	shikimate binding site; other site
439843004248	NAD(P) binding site [chemical binding]; other site
439843004249	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843004250	Major Facilitator Superfamily; Region: MFS_1; pfam07690
439843004251	putative substrate translocation pore; other site
439843004252	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843004253	Major Facilitator Superfamily; Region: MFS_1; pfam07690
439843004254	putative substrate translocation pore; other site
439843004255	Domain of unknown function (DUF1870); Region: DUF1870; pfam08965
439843004256	putative inner membrane protein; Provisional; Region: PRK10983
439843004257	Domain of unknown function DUF20; Region: UPF0118; pfam01594
439843004258	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
439843004259	FAD binding domain; Region: FAD_binding_4; pfam01565
439843004260	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
439843004261	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
439843004262	CoenzymeA binding site [chemical binding]; other site
439843004263	subunit interaction site [polypeptide binding]; other site
439843004264	PHB binding site; other site
439843004265	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
439843004266	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
439843004267	iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504
439843004268	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
439843004269	putative ABC transporter; Region: ycf24; CHL00085
439843004270	cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580
439843004271	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
439843004272	Walker A/P-loop; other site
439843004273	ATP binding site [chemical binding]; other site
439843004274	Q-loop/lid; other site
439843004275	ABC transporter signature motif; other site
439843004276	Walker B; other site
439843004277	D-loop; other site
439843004278	H-loop/switch region; other site
439843004279	cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948
439843004280	FeS assembly protein SufD; Region: sufD; TIGR01981
439843004281	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
439843004282	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
439843004283	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
439843004284	catalytic residue [active]
439843004285	cysteine desufuration protein SufE; Provisional; Region: PRK09296
439843004286	L,D-transpeptidase; Provisional; Region: PRK10190
439843004287	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
439843004288	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
439843004289	murein lipoprotein; Provisional; Region: PRK15396
439843004290	murein lipoprotein; Provisional; Region: PRK15396
439843004291	pyruvate kinase; Provisional; Region: PRK09206
439843004292	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
439843004293	domain interfaces; other site
439843004294	active site
439843004295	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
439843004296	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
439843004297	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
439843004298	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
439843004299	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
439843004300	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
439843004301	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
439843004302	substrate binding site [chemical binding]; other site
439843004303	dimer interface [polypeptide binding]; other site
439843004304	ATP binding site [chemical binding]; other site
439843004305	tetrathionate reductase subunit A; Provisional; Region: PRK14991
439843004306	The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758
439843004307	putative [Fe4-S4] binding site [ion binding]; other site
439843004308	putative molybdopterin cofactor binding site [chemical binding]; other site
439843004309	This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
439843004310	putative molybdopterin cofactor binding site; other site
439843004311	tetrathionate reductase subunit C; Provisional; Region: PRK14992
439843004312	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
439843004313	tetrathionate reductase subunit B; Provisional; Region: PRK14993
439843004314	4Fe-4S binding domain; Region: Fer4; pfam00037
439843004315	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
439843004316	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
439843004317	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
439843004318	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439843004319	dimer interface [polypeptide binding]; other site
439843004320	phosphorylation site [posttranslational modification]
439843004321	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439843004322	ATP binding site [chemical binding]; other site
439843004323	Mg2+ binding site [ion binding]; other site
439843004324	G-X-G motif; other site
439843004325	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
439843004326	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843004327	active site
439843004328	phosphorylation site [posttranslational modification]
439843004329	intermolecular recognition site; other site
439843004330	dimerization interface [polypeptide binding]; other site
439843004331	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
439843004332	DNA binding residues [nucleotide binding]
439843004333	dimerization interface [polypeptide binding]; other site
439843004334	hypothetical protein; Provisional; Region: PRK10292
439843004335	Uncharacterized conserved protein [Function unknown]; Region: COG1683
439843004336	Uncharacterized conserved protein [Function unknown]; Region: COG3272
439843004337	Protein of unknown function (DUF1722); Region: DUF1722; cl01284
439843004338	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
439843004339	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
439843004340	DNA binding residues [nucleotide binding]
439843004341	two component system sensor kinase SsrB; Provisional; Region: PRK15369
439843004342	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843004343	active site
439843004344	phosphorylation site [posttranslational modification]
439843004345	intermolecular recognition site; other site
439843004346	dimerization interface [polypeptide binding]; other site
439843004347	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
439843004348	DNA binding residues [nucleotide binding]
439843004349	dimerization interface [polypeptide binding]; other site
439843004350	two component system sensor kinase SsrA; Provisional; Region: PRK15347
439843004351	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
439843004352	dimerization interface [polypeptide binding]; other site
439843004353	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439843004354	dimer interface [polypeptide binding]; other site
439843004355	phosphorylation site [posttranslational modification]
439843004356	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439843004357	ATP binding site [chemical binding]; other site
439843004358	Mg2+ binding site [ion binding]; other site
439843004359	G-X-G motif; other site
439843004360	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843004361	active site
439843004362	phosphorylation site [posttranslational modification]
439843004363	intermolecular recognition site; other site
439843004364	dimerization interface [polypeptide binding]; other site
439843004365	outer membrane secretin SsaC; Provisional; Region: PRK15346
439843004366	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
439843004367	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
439843004368	type III secretion system protein SsaD; Provisional; Region: PRK15367
439843004369	type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500
439843004370	type III secretion system chaperone SsaE; Provisional; Region: PRK15366
439843004371	pathogenicity island 2 effector protein SseB; Provisional; Region: PRK15364
439843004372	pathogenicity island 2 chaperone protein SscA; Provisional; Region: PRK15363
439843004373	pathogenicity island 2 effector protein SseC; Provisional; Region: PRK15362
439843004374	pathogenicity island 2 effector protein SseD; Provisional; Region: PRK15361
439843004375	pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360
439843004376	type III secretion system chaperone protein SscB; Provisional; Region: PRK15359
439843004377	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
439843004378	TPR motif; other site
439843004379	binding surface
439843004380	pathogenicity island 2 effector protein SseF; Provisional; Region: PRK15358
439843004381	pathogenicity island 2 effector protein SseG; Provisional; Region: PRK15357
439843004382	type III secretion system needle protein SsaG; Provisional; Region: PRK15344
439843004383	type III secretion system protein SsaH; Provisional; Region: PRK15356
439843004384	type III secretion system protein SsaI; Provisional; Region: PRK15355
439843004385	type III secretion system lipoprotein SsaJ; Provisional; Region: PRK15348
439843004386	Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327
439843004387	type III secretion system protein SsaK; Provisional; Region: PRK15354
439843004388	type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499
439843004389	type III secretion system protein SsaL; Provisional; Region: PRK15345
439843004390	HrpJ-like domain; Region: HrpJ; pfam07201
439843004391	TyeA; Region: TyeA; cl07611
439843004392	type III secretion system protein SsaM; Provisional; Region: PRK15353
439843004393	secretion system apparatus protein SsaV; Provisional; Region: PRK12720
439843004394	FHIPEP family; Region: FHIPEP; pfam00771
439843004395	type III secretion system ATPase SsaN; Validated; Region: PRK07594
439843004396	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
439843004397	Walker A motif; other site
439843004398	ATP binding site [chemical binding]; other site
439843004399	Walker B motif; other site
439843004400	type III secretion system protein SsaO; Provisional; Region: PRK15352
439843004401	type III secretion system protein SsaP; Provisional; Region: PRK15351
439843004402	type III secretion system protein SsaQ; Validated; Region: PRK08035
439843004403	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
439843004404	Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790
439843004405	type III secretion system protein SsaS; Provisional; Region: PRK15350
439843004406	type III secretion system protein SsaT; Provisional; Region: PRK15349
439843004407	secretion system apparatus protein SsaU; Reviewed; Region: PRK12721
439843004408	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
439843004409	multidrug efflux protein; Reviewed; Region: PRK01766
439843004410	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
439843004411	cation binding site [ion binding]; other site
439843004412	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
439843004413	Lumazine binding domain; Region: Lum_binding; pfam00677
439843004414	Lumazine binding domain; Region: Lum_binding; pfam00677
439843004415	cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705
439843004416	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439843004417	S-adenosylmethionine binding site [chemical binding]; other site
439843004418	putative transporter; Provisional; Region: PRK11043
439843004419	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843004420	putative substrate translocation pore; other site
439843004421	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
439843004422	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843004423	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
439843004424	dimerization interface [polypeptide binding]; other site
439843004425	DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703
439843004426	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
439843004427	DNA binding site [nucleotide binding]
439843004428	domain linker motif; other site
439843004429	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
439843004430	dimerization interface [polypeptide binding]; other site
439843004431	ligand binding site [chemical binding]; other site
439843004432	superoxide dismutase; Provisional; Region: PRK10543
439843004433	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
439843004434	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
439843004435	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
439843004436	NlpC/P60 family; Region: NLPC_P60; pfam00877
439843004437	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
439843004438	putative GSH binding site [chemical binding]; other site
439843004439	catalytic residues [active]
439843004440	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
439843004441	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
439843004442	dimer interface [polypeptide binding]; other site
439843004443	catalytic site [active]
439843004444	putative active site [active]
439843004445	putative substrate binding site [chemical binding]; other site
439843004446	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
439843004447	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
439843004448	dimer interface [polypeptide binding]; other site
439843004449	active site
439843004450	metal binding site [ion binding]; metal-binding site
439843004451	glutathione binding site [chemical binding]; other site
439843004452	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
439843004453	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
439843004454	FMN binding site [chemical binding]; other site
439843004455	active site
439843004456	substrate binding site [chemical binding]; other site
439843004457	catalytic residue [active]
439843004458	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
439843004459	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
439843004460	Protein of unknown function (DUF1289); Region: DUF1289; cl01304
439843004461	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
439843004462	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
439843004463	active site
439843004464	catalytic tetrad [active]
439843004465	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
439843004466	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
439843004467	E-class dimer interface [polypeptide binding]; other site
439843004468	P-class dimer interface [polypeptide binding]; other site
439843004469	active site
439843004470	Cu2+ binding site [ion binding]; other site
439843004471	Zn2+ binding site [ion binding]; other site
439843004472	Fusaric acid resistance protein family; Region: FUSC; pfam04632
439843004473	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
439843004474	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
439843004475	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
439843004476	HlyD family secretion protein; Region: HlyD_3; pfam13437
439843004477	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
439843004478	transcriptional regulator SlyA; Provisional; Region: PRK03573
439843004479	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
439843004480	Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133
439843004481	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
439843004482	lysozyme inhibitor; Provisional; Region: PRK11372
439843004483	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
439843004484	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
439843004485	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
439843004486	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
439843004487	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
439843004488	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
439843004489	active site
439843004490	HIGH motif; other site
439843004491	dimer interface [polypeptide binding]; other site
439843004492	KMSKS motif; other site
439843004493	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
439843004494	RNA binding surface [nucleotide binding]; other site
439843004495	pyridoxamine kinase; Validated; Region: PRK05756
439843004496	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
439843004497	dimer interface [polypeptide binding]; other site
439843004498	pyridoxal binding site [chemical binding]; other site
439843004499	ATP binding site [chemical binding]; other site
439843004500	glutathionine S-transferase; Provisional; Region: PRK10542
439843004501	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
439843004502	C-terminal domain interface [polypeptide binding]; other site
439843004503	GSH binding site (G-site) [chemical binding]; other site
439843004504	dimer interface [polypeptide binding]; other site
439843004505	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
439843004506	dimer interface [polypeptide binding]; other site
439843004507	N-terminal domain interface [polypeptide binding]; other site
439843004508	substrate binding pocket (H-site) [chemical binding]; other site
439843004509	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
439843004510	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843004511	putative substrate translocation pore; other site
439843004512	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843004513	endonuclease III; Provisional; Region: PRK10702
439843004514	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
439843004515	minor groove reading motif; other site
439843004516	helix-hairpin-helix signature motif; other site
439843004517	substrate binding pocket [chemical binding]; other site
439843004518	active site
439843004519	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
439843004520	electron transport complex RsxE subunit; Provisional; Region: PRK12405
439843004521	electron transport complex protein RnfG; Validated; Region: PRK01908
439843004522	electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816
439843004523	electron transport complex protein RnfC; Provisional; Region: PRK05035
439843004524	SLBB domain; Region: SLBB; pfam10531
439843004525	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
439843004526	electron transport complex protein RnfB; Provisional; Region: PRK05113
439843004527	Putative Fe-S cluster; Region: FeS; cl17515
439843004528	4Fe-4S binding domain; Region: Fer4; pfam00037
439843004529	electron transport complex protein RsxA; Provisional; Region: PRK05151
439843004530	Protein of unknown function (DUF2569); Region: DUF2569; pfam10754
439843004531	oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391
439843004532	putative oxidoreductase; Provisional; Region: PRK11579
439843004533	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
439843004534	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
439843004535	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
439843004536	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
439843004537	active site
439843004538	purine riboside binding site [chemical binding]; other site
439843004539	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
439843004540	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
439843004541	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843004542	homodimer interface [polypeptide binding]; other site
439843004543	catalytic residue [active]
439843004544	bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110
439843004545	PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852
439843004546	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
439843004547	active site turn [active]
439843004548	phosphorylation site [posttranslational modification]
439843004549	DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014
439843004550	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
439843004551	DNA binding site [nucleotide binding]
439843004552	domain linker motif; other site
439843004553	Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289
439843004554	putative dimerization interface [polypeptide binding]; other site
439843004555	putative ligand binding site [chemical binding]; other site
439843004556	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
439843004557	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
439843004558	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
439843004559	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
439843004560	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
439843004561	fumarate hydratase; Provisional; Region: PRK15389
439843004562	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951
439843004563	Fumarase C-terminus; Region: Fumerase_C; pfam05683
439843004564	fumarate hydratase; Reviewed; Region: fumC; PRK00485
439843004565	Class II fumarases; Region: Fumarase_classII; cd01362
439843004566	active site
439843004567	tetramer interface [polypeptide binding]; other site
439843004568	DNA replication terminus site-binding protein; Provisional; Region: PRK02951
439843004569	sensor protein RstB; Provisional; Region: PRK10604
439843004570	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
439843004571	dimerization interface [polypeptide binding]; other site
439843004572	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439843004573	dimer interface [polypeptide binding]; other site
439843004574	phosphorylation site [posttranslational modification]
439843004575	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439843004576	ATP binding site [chemical binding]; other site
439843004577	Mg2+ binding site [ion binding]; other site
439843004578	G-X-G motif; other site
439843004579	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
439843004580	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
439843004581	active site
439843004582	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
439843004583	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
439843004584	trimer interface [polypeptide binding]; other site
439843004585	eyelet of channel; other site
439843004586	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
439843004587	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843004588	active site
439843004589	phosphorylation site [posttranslational modification]
439843004590	intermolecular recognition site; other site
439843004591	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
439843004592	DNA binding site [nucleotide binding]
439843004593	GlpM protein; Region: GlpM; pfam06942
439843004594	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
439843004595	Spore germination protein; Region: Spore_permease; cl17796
439843004596	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
439843004597	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
439843004598	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
439843004599	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
439843004600	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
439843004601	ligand binding site [chemical binding]; other site
439843004602	homodimer interface [polypeptide binding]; other site
439843004603	NAD(P) binding site [chemical binding]; other site
439843004604	trimer interface B [polypeptide binding]; other site
439843004605	trimer interface A [polypeptide binding]; other site
439843004606	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
439843004607	pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444
439843004608	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
439843004609	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287
439843004610	Domain of unknown function DUF20; Region: UPF0118; pfam01594
439843004611	multidrug efflux system protein MdtJ; Provisional; Region: PRK10452
439843004612	multidrug efflux system protein MdtI; Provisional; Region: PRK10650
439843004613	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
439843004614	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
439843004615	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843004616	putative substrate translocation pore; other site
439843004617	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
439843004618	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843004619	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
439843004620	dimerization interface [polypeptide binding]; other site
439843004621	substrate binding pocket [chemical binding]; other site
439843004622	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
439843004623	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
439843004624	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
439843004625	putative dithiobiotin synthetase; Provisional; Region: PRK12374
439843004626	AAA domain; Region: AAA_26; pfam13500
439843004627	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
439843004628	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
439843004629	Cl- selectivity filter; other site
439843004630	Cl- binding residues [ion binding]; other site
439843004631	pore gating glutamate residue; other site
439843004632	dimer interface [polypeptide binding]; other site
439843004633	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
439843004634	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
439843004635	Walker A/P-loop; other site
439843004636	ATP binding site [chemical binding]; other site
439843004637	Q-loop/lid; other site
439843004638	ABC transporter signature motif; other site
439843004639	Walker B; other site
439843004640	D-loop; other site
439843004641	H-loop/switch region; other site
439843004642	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582
439843004643	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843004644	dimer interface [polypeptide binding]; other site
439843004645	conserved gate region; other site
439843004646	ABC-ATPase subunit interface; other site
439843004647	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
439843004648	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843004649	dimer interface [polypeptide binding]; other site
439843004650	conserved gate region; other site
439843004651	putative PBP binding loops; other site
439843004652	ABC-ATPase subunit interface; other site
439843004653	twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621
439843004654	DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302
439843004655	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
439843004656	4Fe-4S binding domain; Region: Fer4; pfam00037
439843004657	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
439843004658	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
439843004659	putative [Fe4-S4] binding site [ion binding]; other site
439843004660	putative molybdopterin cofactor binding site [chemical binding]; other site
439843004661	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
439843004662	putative molybdopterin cofactor binding site; other site
439843004663	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
439843004664	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
439843004665	putative [Fe4-S4] binding site [ion binding]; other site
439843004666	putative molybdopterin cofactor binding site [chemical binding]; other site
439843004667	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
439843004668	putative molybdopterin cofactor binding site; other site
439843004669	Protein of unknown function (DUF1161); Region: DUF1161; pfam06649
439843004670	Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788
439843004671	spermidine N1-acetyltransferase; Provisional; Region: PRK15130
439843004672	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
439843004673	Coenzyme A binding pocket [chemical binding]; other site
439843004674	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
439843004675	hypothetical protein; Provisional; Region: PRK13659
439843004676	hypothetical protein; Provisional; Region: PRK02237
439843004677	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
439843004678	The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322
439843004679	putative active site pocket [active]
439843004680	putative metal binding site [ion binding]; other site
439843004681	putative oxidoreductase; Provisional; Region: PRK10083
439843004682	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
439843004683	putative NAD(P) binding site [chemical binding]; other site
439843004684	catalytic Zn binding site [ion binding]; other site
439843004685	structural Zn binding site [ion binding]; other site
439843004686	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843004687	metabolite-proton symporter; Region: 2A0106; TIGR00883
439843004688	putative substrate translocation pore; other site
439843004689	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
439843004690	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
439843004691	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
439843004692	putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318
439843004693	Transcriptional regulators [Transcription]; Region: GntR; COG1802
439843004694	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439843004695	DNA-binding site [nucleotide binding]; DNA binding site
439843004696	FCD domain; Region: FCD; pfam07729
439843004697	malonic semialdehyde reductase; Provisional; Region: PRK10538
439843004698	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
439843004699	putative NAD(P) binding site [chemical binding]; other site
439843004700	homodimer interface [polypeptide binding]; other site
439843004701	homotetramer interface [polypeptide binding]; other site
439843004702	active site
439843004703	dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280
439843004704	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
439843004705	active site
439843004706	Zn binding site [ion binding]; other site
439843004707	General stress protein [General function prediction only]; Region: GsiB; COG3729
439843004708	hypothetical protein; Validated; Region: PRK03657
439843004709	hypothetical protein; Provisional; Region: PRK10053
439843004710	putative transporter; Provisional; Region: PRK10054
439843004711	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843004712	putative substrate translocation pore; other site
439843004713	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
439843004714	EamA-like transporter family; Region: EamA; pfam00892
439843004715	MarB protein; Region: MarB; pfam13999
439843004716	DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511
439843004717	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439843004718	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439843004719	DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512
439843004720	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
439843004721	inner membrane protein; Provisional; Region: PRK10995
439843004722	putative arabinose transporter; Provisional; Region: PRK03545
439843004723	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843004724	putative substrate translocation pore; other site
439843004725	Transcriptional regulator [Transcription]; Region: LysR; COG0583
439843004726	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843004727	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
439843004728	putative dimerization interface [polypeptide binding]; other site
439843004729	putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968
439843004730	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
439843004731	NAD(P) binding site [chemical binding]; other site
439843004732	catalytic residues [active]
439843004733	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
439843004734	glutaminase; Provisional; Region: PRK00971
439843004735	Domain of unknown function (DUF4186); Region: DUF4186; pfam13811
439843004736	Predicted membrane protein [Function unknown]; Region: COG3781
439843004737	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
439843004738	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
439843004739	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
439843004740	trimer interface [polypeptide binding]; other site
439843004741	eyelet of channel; other site
439843004742	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
439843004743	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
439843004744	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
439843004745	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
439843004746	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
439843004747	Rubredoxin [Energy production and conversion]; Region: COG1773
439843004748	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
439843004749	iron binding site [ion binding]; other site
439843004750	HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965
439843004751	HupF/HypC family; Region: HupF_HypC; cl00394
439843004752	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
439843004753	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
439843004754	putative substrate-binding site; other site
439843004755	nickel binding site [ion binding]; other site
439843004756	Ni,Fe-hydrogenase I cytochrome b subunit [Energy production and conversion]; Region: HyaC; COG1969
439843004757	hydrogenase 1 large subunit; Provisional; Region: PRK10170
439843004758	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
439843004759	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
439843004760	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
439843004761	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
439843004762	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
439843004763	active site
439843004764	Transcriptional regulators [Transcription]; Region: FadR; COG2186
439843004765	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439843004766	DNA-binding site [nucleotide binding]; DNA binding site
439843004767	FCD domain; Region: FCD; pfam07729
439843004768	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
439843004769	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
439843004770	putative NAD(P) binding site [chemical binding]; other site
439843004771	catalytic Zn binding site [ion binding]; other site
439843004772	structural Zn binding site [ion binding]; other site
439843004773	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843004774	D-galactonate transporter; Region: 2A0114; TIGR00893
439843004775	putative substrate translocation pore; other site
439843004776	PhoPQ-activated pathogenicity-related protein [General function prediction only]; Region: PqaA; COG4287
439843004777	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
439843004778	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843004779	Major Facilitator Superfamily; Region: MFS_1; pfam07690
439843004780	putative substrate translocation pore; other site
439843004781	hypothetical protein; Provisional; Region: PRK06184
439843004782	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
439843004783	Transcriptional regulators [Transcription]; Region: MarR; COG1846
439843004784	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
439843004785	putative DNA binding site [nucleotide binding]; other site
439843004786	putative Zn2+ binding site [ion binding]; other site
439843004787	S-adenosylmethionine:tRNA-ribosyltransferase- isomerase (queuine synthetase) [Translation, ribosomal structure and biogenesis]; Region: QueA; COG0809
439843004788	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
439843004789	YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198
439843004790	homotrimer interaction site [polypeptide binding]; other site
439843004791	putative active site [active]
439843004792	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
439843004793	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
439843004794	Protein of unknown function (DUF1493); Region: DUF1493; pfam07377
439843004795	TIR domain; Region: TIR_2; pfam13676
439843004796	Domain of unknown function DUF29; Region: DUF29; pfam01724
439843004797	Transcriptional regulator [Transcription]; Region: LysR; COG0583
439843004798	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843004799	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
439843004800	putative effector binding pocket; other site
439843004801	putative dimerization interface [polypeptide binding]; other site
439843004802	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
439843004803	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
439843004804	FMN binding site [chemical binding]; other site
439843004805	substrate binding site [chemical binding]; other site
439843004806	putative catalytic residue [active]
439843004807	Transcriptional regulators [Transcription]; Region: PurR; COG1609
439843004808	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
439843004809	DNA binding site [nucleotide binding]
439843004810	domain linker motif; other site
439843004811	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
439843004812	dimerization interface (closed form) [polypeptide binding]; other site
439843004813	ligand binding site [chemical binding]; other site
439843004814	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
439843004815	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
439843004816	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
439843004817	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843004818	homodimer interface [polypeptide binding]; other site
439843004819	catalytic residue [active]
439843004820	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
439843004821	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
439843004822	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
439843004823	active site
439843004824	catalytic site [active]
439843004825	Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280
439843004826	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
439843004827	active site
439843004828	catalytic site [active]
439843004829	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
439843004830	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
439843004831	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
439843004832	catalytic site [active]
439843004833	active site
439843004834	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
439843004835	Protein of unknown function (DUF1264); Region: DUF1264; pfam06884
439843004836	acid-resistance protein; Provisional; Region: hdeB; PRK11566
439843004837	hemolysin E; Provisional; Region: hlyE; PRK11376
439843004838	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
439843004839	biofilm-dependent modulation protein; Provisional; Region: PRK11436
439843004840	malate dehydrogenase; Provisional; Region: PRK13529
439843004841	Malic enzyme, N-terminal domain; Region: malic; pfam00390
439843004842	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
439843004843	NAD(P) binding site [chemical binding]; other site
439843004844	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
439843004845	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
439843004846	NAD binding site [chemical binding]; other site
439843004847	substrate binding site [chemical binding]; other site
439843004848	catalytic Zn binding site [ion binding]; other site
439843004849	tetramer interface [polypeptide binding]; other site
439843004850	structural Zn binding site [ion binding]; other site
439843004851	formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179
439843004852	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
439843004853	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
439843004854	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
439843004855	aromatic amino acid exporter; Provisional; Region: PRK11689
439843004856	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
439843004857	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
439843004858	trimer interface [polypeptide binding]; other site
439843004859	eyelet of channel; other site
439843004860	Uncharacterized conserved protein [Function unknown]; Region: COG3791
439843004861	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
439843004862	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843004863	putative substrate translocation pore; other site
439843004864	TetR family transcriptional regulator; Provisional; Region: PRK14996
439843004865	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
439843004866	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
439843004867	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
439843004868	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
439843004869	[4Fe-4S] binding site [ion binding]; other site
439843004870	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
439843004871	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
439843004872	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
439843004873	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
439843004874	molybdopterin cofactor binding site; other site
439843004875	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
439843004876	nitrate reductase 2 subunit delta; Provisional; Region: PRK15054
439843004877	respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351
439843004878	hypothetical protein; Provisional; Region: PRK10281
439843004879	N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047
439843004880	L-asparagine permease; Provisional; Region: PRK15049
439843004881	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
439843004882	Uncharacterized conserved protein [Function unknown]; Region: COG3391
439843004883	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
439843004884	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
439843004885	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
439843004886	N-terminal plug; other site
439843004887	ligand-binding site [chemical binding]; other site
439843004888	colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414
439843004889	DNA-binding site [nucleotide binding]; DNA binding site
439843004890	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
439843004891	FCD domain; Region: FCD; pfam07729
439843004892	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
439843004893	Prostaglandin dehydrogenases; Region: PGDH; cd05288
439843004894	NAD(P) binding site [chemical binding]; other site
439843004895	substrate binding site [chemical binding]; other site
439843004896	dimer interface [polypeptide binding]; other site
439843004897	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
439843004898	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
439843004899	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
439843004900	Protein of unknown function (DUF2526); Region: DUF2526; pfam10735
439843004901	Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfB; COG4457
439843004902	Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458
439843004903	Protein of unknown function (DUF2566); Region: DUF2566; pfam10753
439843004904	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
439843004905	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
439843004906	tetrameric interface [polypeptide binding]; other site
439843004907	NAD binding site [chemical binding]; other site
439843004908	catalytic residues [active]
439843004909	substrate binding site [chemical binding]; other site
439843004910	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
439843004911	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439843004912	DNA-binding site [nucleotide binding]; DNA binding site
439843004913	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
439843004914	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843004915	homodimer interface [polypeptide binding]; other site
439843004916	catalytic residue [active]
439843004917	D-alanyl-D-alanine dipeptidase [Cell envelope biogenesis, outer membrane]; Region: DdpX; COG2173
439843004918	secreted effector protein SifB; Provisional; Region: sifB; PRK09499
439843004919	Protein of unknown function (DUF2554); Region: DUF2554; pfam10829
439843004920	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
439843004921	Peptidase family U32; Region: Peptidase_U32; pfam01136
439843004922	Collagenase; Region: DUF3656; pfam12392
439843004923	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
439843004924	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
439843004925	non-specific DNA binding site [nucleotide binding]; other site
439843004926	salt bridge; other site
439843004927	sequence-specific DNA binding site [nucleotide binding]; other site
439843004928	Cupin domain; Region: Cupin_2; pfam07883
439843004929	Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135
439843004930	benzoate transporter; Region: benE; TIGR00843
439843004931	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
439843004932	tellurite resistance protein TehB; Provisional; Region: PRK11207
439843004933	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439843004934	S-adenosylmethionine binding site [chemical binding]; other site
439843004935	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
439843004936	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324
439843004937	gating phenylalanine in ion channel; other site
439843004938	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
439843004939	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
439843004940	putative trimer interface [polypeptide binding]; other site
439843004941	putative CoA binding site [chemical binding]; other site
439843004942	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208
439843004943	putative trimer interface [polypeptide binding]; other site
439843004944	putative CoA binding site [chemical binding]; other site
439843004945	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
439843004946	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
439843004947	Coenzyme A binding pocket [chemical binding]; other site
439843004948	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
439843004949	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
439843004950	oligomer interface [polypeptide binding]; other site
439843004951	active site
439843004952	metal binding site [ion binding]; metal-binding site
439843004953	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
439843004954	active site
439843004955	P-loop; other site
439843004956	phosphorylation site [posttranslational modification]
439843004957	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
439843004958	PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827
439843004959	membrane complex biogenesis protein, BtpA family; Region: thylakoid_BtpA; TIGR00259
439843004960	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
439843004961	active site
439843004962	phosphorylation site [posttranslational modification]
439843004963	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
439843004964	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
439843004965	substrate binding site [chemical binding]; other site
439843004966	hexamer interface [polypeptide binding]; other site
439843004967	metal binding site [ion binding]; metal-binding site
439843004968	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
439843004969	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
439843004970	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
439843004971	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
439843004972	Coenzyme A binding pocket [chemical binding]; other site
439843004973	L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2.  This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737
439843004974	teramer interface [polypeptide binding]; other site
439843004975	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
439843004976	active site
439843004977	FMN binding site [chemical binding]; other site
439843004978	catalytic residues [active]
439843004979	Uncharacterized conserved protein [Function unknown]; Region: COG2353
439843004980	Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131
439843004981	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
439843004982	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
439843004983	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
439843004984	substrate binding pocket [chemical binding]; other site
439843004985	catalytic triad [active]
439843004986	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
439843004987	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383
439843004988	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
439843004989	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843004990	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
439843004991	dimerization interface [polypeptide binding]; other site
439843004992	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
439843004993	dimer interface [polypeptide binding]; other site
439843004994	ligand binding site [chemical binding]; other site
439843004995	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
439843004996	HAMP domain; Region: HAMP; pfam00672
439843004997	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
439843004998	dimer interface [polypeptide binding]; other site
439843004999	putative CheW interface [polypeptide binding]; other site
439843005000	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
439843005001	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
439843005002	substrate binding site [chemical binding]; other site
439843005003	catalytic Zn binding site [ion binding]; other site
439843005004	NAD binding site [chemical binding]; other site
439843005005	structural Zn binding site [ion binding]; other site
439843005006	dimer interface [polypeptide binding]; other site
439843005007	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
439843005008	putative metal binding site [ion binding]; other site
439843005009	putative homodimer interface [polypeptide binding]; other site
439843005010	putative homotetramer interface [polypeptide binding]; other site
439843005011	putative homodimer-homodimer interface [polypeptide binding]; other site
439843005012	putative allosteric switch controlling residues; other site
439843005013	Sif protein; Region: Sif; cl11505
439843005014	Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240
439843005015	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
439843005016	active site
439843005017	catalytic triad [active]
439843005018	oxyanion hole [active]
439843005019	Predicted membrane protein [Function unknown]; Region: COG3326
439843005020	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
439843005021	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
439843005022	substrate binding pocket [chemical binding]; other site
439843005023	membrane-bound complex binding site; other site
439843005024	hinge residues; other site
439843005025	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
439843005026	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843005027	dimer interface [polypeptide binding]; other site
439843005028	conserved gate region; other site
439843005029	putative PBP binding loops; other site
439843005030	ABC-ATPase subunit interface; other site
439843005031	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
439843005032	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439843005033	Walker A/P-loop; other site
439843005034	ATP binding site [chemical binding]; other site
439843005035	Q-loop/lid; other site
439843005036	ABC transporter signature motif; other site
439843005037	Walker B; other site
439843005038	D-loop; other site
439843005039	H-loop/switch region; other site
439843005040	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
439843005041	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843005042	dimer interface [polypeptide binding]; other site
439843005043	conserved gate region; other site
439843005044	putative PBP binding loops; other site
439843005045	ABC-ATPase subunit interface; other site
439843005046	Predicted membrane protein [Function unknown]; Region: COG5305
439843005047	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439843005048	S-adenosylmethionine binding site [chemical binding]; other site
439843005049	cytochrome b561; Provisional; Region: PRK11513
439843005050	Uncharacterized conserved protein [Function unknown]; Region: COG1434
439843005051	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
439843005052	putative active site [active]
439843005053	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
439843005054	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
439843005055	ATP binding site [chemical binding]; other site
439843005056	putative Mg++ binding site [ion binding]; other site
439843005057	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
439843005058	nucleotide binding region [chemical binding]; other site
439843005059	ATP-binding site [chemical binding]; other site
439843005060	Helicase associated domain (HA2); Region: HA2; pfam04408
439843005061	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
439843005062	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
439843005063	azoreductase; Reviewed; Region: PRK00170
439843005064	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
439843005065	Uncharacterized conserved protein [Function unknown]; Region: COG3791
439843005066	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784
439843005067	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
439843005068	hypothetical protein; Provisional; Region: PRK10695
439843005069	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
439843005070	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
439843005071	putative ligand binding site [chemical binding]; other site
439843005072	putative NAD binding site [chemical binding]; other site
439843005073	catalytic site [active]
439843005074	heat-inducible protein; Provisional; Region: PRK10449
439843005075	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
439843005076	Domain of unknown function (DUF333); Region: DUF333; pfam03891
439843005077	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
439843005078	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
439843005079	dimer interface [polypeptide binding]; other site
439843005080	PYR/PP interface [polypeptide binding]; other site
439843005081	TPP binding site [chemical binding]; other site
439843005082	substrate binding site [chemical binding]; other site
439843005083	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
439843005084	Domain of unknown function; Region: EKR; smart00890
439843005085	4Fe-4S binding domain; Region: Fer4_6; pfam12837
439843005086	4Fe-4S binding domain; Region: Fer4; pfam00037
439843005087	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
439843005088	TPP-binding site [chemical binding]; other site
439843005089	dimer interface [polypeptide binding]; other site
439843005090	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
439843005091	Ligand Binding Site [chemical binding]; other site
439843005092	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
439843005093	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
439843005094	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
439843005095	Ligand Binding Site [chemical binding]; other site
439843005096	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
439843005097	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
439843005098	ATP binding site [chemical binding]; other site
439843005099	Mg++ binding site [ion binding]; other site
439843005100	motif III; other site
439843005101	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
439843005102	nucleotide binding region [chemical binding]; other site
439843005103	ATP-binding site [chemical binding]; other site
439843005104	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
439843005105	putative RNA binding site [nucleotide binding]; other site
439843005106	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
439843005107	Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833
439843005108	Cl binding site [ion binding]; other site
439843005109	oligomer interface [polypeptide binding]; other site
439843005110	HAMP domain; Region: HAMP; pfam00672
439843005111	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
439843005112	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
439843005113	dimer interface [polypeptide binding]; other site
439843005114	putative CheW interface [polypeptide binding]; other site
439843005115	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
439843005116	Smr domain; Region: Smr; pfam01713
439843005117	O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286
439843005118	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
439843005119	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
439843005120	DNA binding site [nucleotide binding]
439843005121	active site
439843005122	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
439843005123	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
439843005124	ligand binding site [chemical binding]; other site
439843005125	flexible hinge region; other site
439843005126	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
439843005127	putative switch regulator; other site
439843005128	non-specific DNA interactions [nucleotide binding]; other site
439843005129	DNA binding site [nucleotide binding]
439843005130	sequence specific DNA binding site [nucleotide binding]; other site
439843005131	putative cAMP binding site [chemical binding]; other site
439843005132	universal stress protein UspE; Provisional; Region: PRK11175
439843005133	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
439843005134	Ligand Binding Site [chemical binding]; other site
439843005135	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
439843005136	Ligand Binding Site [chemical binding]; other site
439843005137	Protein of unknown function (DUF2534); Region: DUF2534; pfam10749
439843005138	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
439843005139	Mechanosensitive ion channel; Region: MS_channel; pfam00924
439843005140	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
439843005141	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
439843005142	non-specific DNA binding site [nucleotide binding]; other site
439843005143	salt bridge; other site
439843005144	sequence-specific DNA binding site [nucleotide binding]; other site
439843005145	Cupin domain; Region: Cupin_2; pfam07883
439843005146	Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382
439843005147	B3/4 domain; Region: B3_4; pfam03483
439843005148	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
439843005149	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
439843005150	right oriC-binding transcriptional activator; Provisional; Region: PRK15121
439843005151	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439843005152	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
439843005153	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
439843005154	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
439843005155	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
439843005156	oxidoreductase; Provisional; Region: PRK12742
439843005157	classical (c) SDRs; Region: SDR_c; cd05233
439843005158	NAD(P) binding site [chemical binding]; other site
439843005159	active site
439843005160	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
439843005161	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
439843005162	active site
439843005163	catalytic tetrad [active]
439843005164	Transcriptional regulator [Transcription]; Region: LysR; COG0583
439843005165	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843005166	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
439843005167	putative effector binding pocket; other site
439843005168	putative dimerization interface [polypeptide binding]; other site
439843005169	phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259
439843005170	NmrA-like family; Region: NmrA; pfam05368
439843005171	NAD(P) binding site [chemical binding]; other site
439843005172	active site lysine
439843005173	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
439843005174	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
439843005175	peptide binding site [polypeptide binding]; other site
439843005176	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
439843005177	Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904
439843005178	putative active site [active]
439843005179	Zn binding site [ion binding]; other site
439843005180	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
439843005181	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
439843005182	active site
439843005183	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
439843005184	dimer interface [polypeptide binding]; other site
439843005185	catalytic triad [active]
439843005186	peroxidatic and resolving cysteines [active]
439843005187	DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820
439843005188	N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877
439843005189	putative aromatic amino acid binding site; other site
439843005190	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439843005191	Walker A motif; other site
439843005192	ATP binding site [chemical binding]; other site
439843005193	Walker B motif; other site
439843005194	arginine finger; other site
439843005195	hypothetical protein; Provisional; Region: PRK05415
439843005196	TIGR01620 family protein; Region: hyp_HI0043
439843005197	Predicted ATPase [General function prediction only]; Region: COG3106
439843005198	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
439843005199	active site residue [active]
439843005200	peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497
439843005201	DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697
439843005202	phage shock protein C; Region: phageshock_pspC; TIGR02978
439843005203	phage shock protein B; Provisional; Region: pspB; PRK09458
439843005204	phage shock protein PspA; Provisional; Region: PRK10698
439843005205	phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608
439843005206	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439843005207	Walker A motif; other site
439843005208	ATP binding site [chemical binding]; other site
439843005209	Walker B motif; other site
439843005210	arginine finger; other site
439843005211	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
439843005212	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
439843005213	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
439843005214	peptide binding site [polypeptide binding]; other site
439843005215	antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110
439843005216	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843005217	dimer interface [polypeptide binding]; other site
439843005218	conserved gate region; other site
439843005219	putative PBP binding loops; other site
439843005220	ABC-ATPase subunit interface; other site
439843005221	antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111
439843005222	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
439843005223	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843005224	dimer interface [polypeptide binding]; other site
439843005225	conserved gate region; other site
439843005226	putative PBP binding loops; other site
439843005227	ABC-ATPase subunit interface; other site
439843005228	antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093
439843005229	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
439843005230	Walker A/P-loop; other site
439843005231	ATP binding site [chemical binding]; other site
439843005232	Q-loop/lid; other site
439843005233	ABC transporter signature motif; other site
439843005234	Walker B; other site
439843005235	D-loop; other site
439843005236	H-loop/switch region; other site
439843005237	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
439843005238	antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112
439843005239	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
439843005240	Walker A/P-loop; other site
439843005241	ATP binding site [chemical binding]; other site
439843005242	Q-loop/lid; other site
439843005243	ABC transporter signature motif; other site
439843005244	Walker B; other site
439843005245	D-loop; other site
439843005246	H-loop/switch region; other site
439843005247	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
439843005248	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984
439843005249	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
439843005250	NAD binding site [chemical binding]; other site
439843005251	homotetramer interface [polypeptide binding]; other site
439843005252	homodimer interface [polypeptide binding]; other site
439843005253	substrate binding site [chemical binding]; other site
439843005254	active site
439843005255	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950
439843005256	Uncharacterized conserved protein [Function unknown]; Region: COG2128
439843005257	exoribonuclease II; Provisional; Region: PRK05054
439843005258	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
439843005259	RNB domain; Region: RNB; pfam00773
439843005260	S1 RNA binding domain; Region: S1; pfam00575
439843005261	RNase II stability modulator; Provisional; Region: PRK10060
439843005262	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
439843005263	putative active site [active]
439843005264	heme pocket [chemical binding]; other site
439843005265	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
439843005266	metal binding site [ion binding]; metal-binding site
439843005267	active site
439843005268	I-site; other site
439843005269	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
439843005270	hypothetical protein; Provisional; Region: PRK13658
439843005271	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
439843005272	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
439843005273	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
439843005274	lipoprotein; Provisional; Region: PRK10540
439843005275	translation initiation factor Sui1; Validated; Region: PRK06824
439843005276	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
439843005277	putative rRNA binding site [nucleotide binding]; other site
439843005278	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
439843005279	active site
439843005280	dimer interface [polypeptide binding]; other site
439843005281	Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956
439843005282	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
439843005283	binding surface
439843005284	TPR motif; other site
439843005285	Predicted membrane protein [Function unknown]; Region: COG3771
439843005286	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
439843005287	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
439843005288	active site
439843005289	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
439843005290	dimerization interface [polypeptide binding]; other site
439843005291	active site
439843005292	aconitate hydratase; Validated; Region: PRK09277
439843005293	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
439843005294	substrate binding site [chemical binding]; other site
439843005295	ligand binding site [chemical binding]; other site
439843005296	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
439843005297	substrate binding site [chemical binding]; other site
439843005298	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
439843005299	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843005300	The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443
439843005301	substrate binding site [chemical binding]; other site
439843005302	putative dimerization interface [polypeptide binding]; other site
439843005303	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
439843005304	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
439843005305	active site
439843005306	interdomain interaction site; other site
439843005307	putative metal-binding site [ion binding]; other site
439843005308	nucleotide binding site [chemical binding]; other site
439843005309	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
439843005310	domain I; other site
439843005311	DNA binding groove [nucleotide binding]
439843005312	phosphate binding site [ion binding]; other site
439843005313	domain II; other site
439843005314	domain III; other site
439843005315	nucleotide binding site [chemical binding]; other site
439843005316	catalytic site [active]
439843005317	domain IV; other site
439843005318	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
439843005319	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
439843005320	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
439843005321	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
439843005322	hypothetical protein; Provisional; Region: PRK11037
439843005323	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
439843005324	putative inner membrane peptidase; Provisional; Region: PRK11778
439843005325	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
439843005326	tandem repeat interface [polypeptide binding]; other site
439843005327	oligomer interface [polypeptide binding]; other site
439843005328	active site residues [active]
439843005329	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
439843005330	Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340
439843005331	NADP binding site [chemical binding]; other site
439843005332	homodimer interface [polypeptide binding]; other site
439843005333	active site
439843005334	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
439843005335	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
439843005336	homodimer interface [polypeptide binding]; other site
439843005337	Walker A motif; other site
439843005338	ATP binding site [chemical binding]; other site
439843005339	hydroxycobalamin binding site [chemical binding]; other site
439843005340	Walker B motif; other site
439843005341	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
439843005342	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
439843005343	RNA binding surface [nucleotide binding]; other site
439843005344	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
439843005345	probable active site [active]
439843005346	hypothetical protein; Provisional; Region: PRK11630
439843005347	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
439843005348	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
439843005349	active site
439843005350	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
439843005351	Tryptophan operon leader
439843005352	anthranilate synthase component I; Provisional; Region: PRK13564
439843005353	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
439843005354	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
439843005355	bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522
439843005356	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
439843005357	glutamine binding [chemical binding]; other site
439843005358	catalytic triad [active]
439843005359	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
439843005360	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
439843005361	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
439843005362	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
439843005363	active site
439843005364	ribulose/triose binding site [chemical binding]; other site
439843005365	phosphate binding site [ion binding]; other site
439843005366	substrate (anthranilate) binding pocket [chemical binding]; other site
439843005367	product (indole) binding pocket [chemical binding]; other site
439843005368	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
439843005369	active site
439843005370	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
439843005371	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
439843005372	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843005373	catalytic residue [active]
439843005374	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
439843005375	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
439843005376	substrate binding site [chemical binding]; other site
439843005377	active site
439843005378	catalytic residues [active]
439843005379	heterodimer interface [polypeptide binding]; other site
439843005380	General stress protein [General function prediction only]; Region: GsiB; COG3729
439843005381	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
439843005382	dimerization interface [polypeptide binding]; other site
439843005383	metal binding site [ion binding]; metal-binding site
439843005384	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
439843005385	dinuclear metal binding motif [ion binding]; other site
439843005386	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
439843005387	dimanganese center [ion binding]; other site
439843005388	outer membrane protein W; Provisional; Region: PRK10959
439843005389	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
439843005390	hypothetical protein; Provisional; Region: PRK02868
439843005391	intracellular septation protein A; Reviewed; Region: PRK00259
439843005392	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
439843005393	transport protein TonB; Provisional; Region: PRK10819
439843005394	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
439843005395	YciI-like protein; Reviewed; Region: PRK11370
439843005396	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
439843005397	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
439843005398	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
439843005399	putative active site [active]
439843005400	catalytic site [active]
439843005401	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
439843005402	putative active site [active]
439843005403	catalytic site [active]
439843005404	dsDNA-mimic protein; Reviewed; Region: PRK05094
439843005405	Ion transport protein; Region: Ion_trans; pfam00520
439843005406	Ion channel; Region: Ion_trans_2; pfam07885
439843005407	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
439843005408	Double zinc ribbon; Region: DZR; pfam12773
439843005409	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
439843005410	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
439843005411	Walker A/P-loop; other site
439843005412	ATP binding site [chemical binding]; other site
439843005413	Q-loop/lid; other site
439843005414	ABC transporter signature motif; other site
439843005415	Walker B; other site
439843005416	D-loop; other site
439843005417	H-loop/switch region; other site
439843005418	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
439843005419	oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473
439843005420	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
439843005421	Walker A/P-loop; other site
439843005422	ATP binding site [chemical binding]; other site
439843005423	Q-loop/lid; other site
439843005424	ABC transporter signature motif; other site
439843005425	Walker B; other site
439843005426	D-loop; other site
439843005427	H-loop/switch region; other site
439843005428	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
439843005429	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
439843005430	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
439843005431	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843005432	dimer interface [polypeptide binding]; other site
439843005433	conserved gate region; other site
439843005434	ABC-ATPase subunit interface; other site
439843005435	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
439843005436	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843005437	dimer interface [polypeptide binding]; other site
439843005438	conserved gate region; other site
439843005439	putative PBP binding loops; other site
439843005440	ABC-ATPase subunit interface; other site
439843005441	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
439843005442	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
439843005443	peptide binding site [polypeptide binding]; other site
439843005444	hypothetical protein; Provisional; Region: PRK11111
439843005445	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
439843005446	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
439843005447	putative catalytic cysteine [active]
439843005448	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
439843005449	putative active site [active]
439843005450	metal binding site [ion binding]; metal-binding site
439843005451	thymidine kinase; Provisional; Region: PRK04296
439843005452	global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947
439843005453	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
439843005454	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
439843005455	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
439843005456	active site
439843005457	tetramer interface; other site
439843005458	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843005459	active site
439843005460	response regulator of RpoS; Provisional; Region: PRK10693
439843005461	phosphorylation site [posttranslational modification]
439843005462	intermolecular recognition site; other site
439843005463	dimerization interface [polypeptide binding]; other site
439843005464	hypothetical protein; Provisional; Region: PRK10279
439843005465	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
439843005466	active site
439843005467	nucleophile elbow; other site
439843005468	SEC-C motif; Region: SEC-C; pfam02810
439843005469	hypothetical protein; Provisional; Region: PRK04233
439843005470	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
439843005471	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
439843005472	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
439843005473	putative active site [active]
439843005474	putative substrate binding site [chemical binding]; other site
439843005475	putative cosubstrate binding site; other site
439843005476	catalytic site [active]
439843005477	Predicted ATPase [General function prediction only]; Region: COG3911
439843005478	AAA domain; Region: AAA_28; pfam13521
439843005479	respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351
439843005480	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
439843005481	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
439843005482	4Fe-4S binding domain; Region: Fer4; cl02805
439843005483	respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580
439843005484	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
439843005485	[4Fe-4S] binding site [ion binding]; other site
439843005486	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
439843005487	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
439843005488	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
439843005489	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
439843005490	molybdopterin cofactor binding site; other site
439843005491	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
439843005492	nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600
439843005493	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
439843005494	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
439843005495	dimerization interface [polypeptide binding]; other site
439843005496	Histidine kinase; Region: HisKA_3; pfam07730
439843005497	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439843005498	ATP binding site [chemical binding]; other site
439843005499	Mg2+ binding site [ion binding]; other site
439843005500	G-X-G motif; other site
439843005501	transcriptional regulator NarL; Provisional; Region: PRK10651
439843005502	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843005503	active site
439843005504	phosphorylation site [posttranslational modification]
439843005505	intermolecular recognition site; other site
439843005506	dimerization interface [polypeptide binding]; other site
439843005507	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
439843005508	DNA binding residues [nucleotide binding]
439843005509	dimerization interface [polypeptide binding]; other site
439843005510	putative invasin; Provisional; Region: PRK10177
439843005511	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
439843005512	Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553
439843005513	cation transport regulator; Reviewed; Region: chaB; PRK09582
439843005514	calcium/sodium:proton antiporter; Provisional; Region: PRK10599
439843005515	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
439843005516	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877
439843005517	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
439843005518	hypothetical protein; Provisional; Region: PRK10941
439843005519	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
439843005520	hypothetical protein; Provisional; Region: PRK10278
439843005521	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
439843005522	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439843005523	peptide chain release factor 1; Validated; Region: prfA; PRK00591
439843005524	This domain is found in peptide chain release factors; Region: PCRF; smart00937
439843005525	RF-1 domain; Region: RF-1; pfam00472
439843005526	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
439843005527	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
439843005528	tRNA; other site
439843005529	putative tRNA binding site [nucleotide binding]; other site
439843005530	putative NADP binding site [chemical binding]; other site
439843005531	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
439843005532	Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017
439843005533	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
439843005534	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
439843005535	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
439843005536	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
439843005537	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
439843005538	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
439843005539	active site
439843005540	putative transporter; Provisional; Region: PRK11660
439843005541	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
439843005542	Sulfate transporter family; Region: Sulfate_transp; pfam00916
439843005543	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
439843005544	hypothetical protein; Provisional; Region: PRK10692
439843005545	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
439843005546	putative active site [active]
439843005547	catalytic residue [active]
439843005548	GTP-binding protein YchF; Reviewed; Region: PRK09601
439843005549	YchF GTPase; Region: YchF; cd01900
439843005550	G1 box; other site
439843005551	GTP/Mg2+ binding site [chemical binding]; other site
439843005552	Switch I region; other site
439843005553	G2 box; other site
439843005554	Switch II region; other site
439843005555	G3 box; other site
439843005556	G4 box; other site
439843005557	G5 box; other site
439843005558	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
439843005559	Protein of unknown function (DUF2743); Region: DUF2743; pfam10899
439843005560	Protein of unknown function (DUF4427); Region: DUF4427; pfam14468
439843005561	hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391
439843005562	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
439843005563	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
439843005564	hydrogenase 1 large subunit; Provisional; Region: PRK10170
439843005565	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
439843005566	hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171
439843005567	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
439843005568	putative substrate-binding site; other site
439843005569	nickel binding site [ion binding]; other site
439843005570	HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965
439843005571	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
439843005572	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
439843005573	cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035
439843005574	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
439843005575	cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028
439843005576	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
439843005577	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
439843005578	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
439843005579	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
439843005580	NAD(P) binding site [chemical binding]; other site
439843005581	trehalase; Provisional; Region: treA; PRK13271
439843005582	Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626
439843005583	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
439843005584	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
439843005585	Flagellar regulator YcgR; Region: YcgR; pfam07317
439843005586	PilZ domain; Region: PilZ; pfam07238
439843005587	lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470
439843005588	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
439843005589	N-acetyl-D-glucosamine binding site [chemical binding]; other site
439843005590	catalytic residue [active]
439843005591	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
439843005592	dimer interface [polypeptide binding]; other site
439843005593	catalytic triad [active]
439843005594	NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263
439843005595	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
439843005596	TrkA-C domain; Region: TrkA_C; pfam02080
439843005597	Transporter associated domain; Region: CorC_HlyC; smart01091
439843005598	alanine racemase; Reviewed; Region: dadX; PRK03646
439843005599	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
439843005600	active site
439843005601	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
439843005602	substrate binding site [chemical binding]; other site
439843005603	catalytic residues [active]
439843005604	dimer interface [polypeptide binding]; other site
439843005605	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
439843005606	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
439843005607	SpoVR family protein; Provisional; Region: PRK11767
439843005608	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
439843005609	fatty acid metabolism regulator; Provisional; Region: PRK04984
439843005610	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439843005611	DNA-binding site [nucleotide binding]; DNA binding site
439843005612	FadR C-terminal domain; Region: FadR_C; pfam07840
439843005613	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
439843005614	transmembrane helices; other site
439843005615	disulfide bond formation protein B; Provisional; Region: PRK01749
439843005616	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
439843005617	GnsA/GnsB family; Region: GnsAB; pfam08178
439843005618	hypothetical protein; Provisional; Region: PRK05170
439843005619	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
439843005620	hypothetical protein; Provisional; Region: PRK10691
439843005621	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100
439843005622	septum formation inhibitor; Reviewed; Region: minC; PRK03511
439843005623	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
439843005624	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
439843005625	cell division inhibitor MinD; Provisional; Region: PRK10818
439843005626	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
439843005627	Switch I; other site
439843005628	Switch II; other site
439843005629	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
439843005630	ribonuclease D; Provisional; Region: PRK10829
439843005631	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
439843005632	catalytic site [active]
439843005633	putative active site [active]
439843005634	putative substrate binding site [chemical binding]; other site
439843005635	HRDC domain; Region: HRDC; cl02578
439843005636	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
439843005637	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
439843005638	acyl-activating enzyme (AAE) consensus motif; other site
439843005639	putative AMP binding site [chemical binding]; other site
439843005640	putative active site [active]
439843005641	putative CoA binding site [chemical binding]; other site
439843005642	Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065
439843005643	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
439843005644	Glycoprotease family; Region: Peptidase_M22; pfam00814
439843005645	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
439843005646	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
439843005647	DEAD_2; Region: DEAD_2; pfam06733
439843005648	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
439843005649	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
439843005650	homotrimer interaction site [polypeptide binding]; other site
439843005651	putative active site [active]
439843005652	hypothetical protein; Provisional; Region: PRK05114
439843005653	aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465
439843005654	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
439843005655	aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553
439843005656	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
439843005657	putative active site [active]
439843005658	putative CoA binding site [chemical binding]; other site
439843005659	nudix motif; other site
439843005660	metal binding site [ion binding]; metal-binding site
439843005661	L-serine deaminase; Provisional; Region: PRK15023
439843005662	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
439843005663	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
439843005664	phage resistance protein; Provisional; Region: PRK10551
439843005665	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
439843005666	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
439843005667	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
439843005668	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
439843005669	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
439843005670	Transporter associated domain; Region: CorC_HlyC; smart01091
439843005671	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
439843005672	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
439843005673	active pocket/dimerization site; other site
439843005674	active site
439843005675	phosphorylation site [posttranslational modification]
439843005676	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
439843005677	active site
439843005678	phosphorylation site [posttranslational modification]
439843005679	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
439843005680	PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103
439843005681	hypothetical protein; Provisional; Region: PRK02913
439843005682	yybP-ykoY leader
439843005683	hypothetical protein; Provisional; Region: PRK11469
439843005684	Domain of unknown function DUF; Region: DUF204; pfam02659
439843005685	Domain of unknown function DUF; Region: DUF204; pfam02659
439843005686	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
439843005687	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439843005688	S-adenosylmethionine binding site [chemical binding]; other site
439843005689	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
439843005690	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
439843005691	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
439843005692	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
439843005693	DNA-binding site [nucleotide binding]; DNA binding site
439843005694	RNA-binding motif; other site
439843005695	YebO-like protein; Region: YebO; pfam13974
439843005696	PhoPQ regulatory protein; Provisional; Region: PRK10299
439843005697	YobH-like protein; Region: YobH; pfam13996
439843005698	DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090
439843005699	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
439843005700	dimerization interface [polypeptide binding]; other site
439843005701	putative Zn2+ binding site [ion binding]; other site
439843005702	putative DNA binding site [nucleotide binding]; other site
439843005703	Bacterial transcriptional regulator; Region: IclR; pfam01614
439843005704	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843005705	Major Facilitator Superfamily; Region: MFS_1; pfam07690
439843005706	putative substrate translocation pore; other site
439843005707	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843005708	heat shock protein HtpX; Provisional; Region: PRK05457
439843005709	carboxy-terminal protease; Provisional; Region: PRK11186
439843005710	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
439843005711	protein binding site [polypeptide binding]; other site
439843005712	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
439843005713	Catalytic dyad [active]
439843005714	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
439843005715	ProP expression regulator; Provisional; Region: PRK04950
439843005716	ProQ/FINO family; Region: ProQ; pfam04352
439843005717	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
439843005718	GAF domain; Region: GAF_2; pfam13185
439843005719	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
439843005720	Paraquat-inducible protein A; Region: PqiA; pfam04403
439843005721	Paraquat-inducible protein A; Region: PqiA; pfam04403
439843005722	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
439843005723	mce related protein; Region: MCE; pfam02470
439843005724	mce related protein; Region: MCE; pfam02470
439843005725	mce related protein; Region: MCE; pfam02470
439843005726	mce related protein; Region: MCE; pfam02470
439843005727	mce related protein; Region: MCE; pfam02470
439843005728	mce related protein; Region: MCE; pfam02470
439843005729	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
439843005730	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
439843005731	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
439843005732	Protein of unknown function (DUF1480); Region: DUF1480; pfam07351
439843005733	Protein of unknown function (DUF1482); Region: DUF1482; pfam07358
439843005734	serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439
439843005735	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
439843005736	type III secretion protein SopE2; Provisional; Region: PRK15280
439843005737	Salmonella type III secretion SopE effector N-terminus; Region: SecIII_SopE_N; pfam05364
439843005738	SopE GEF domain; Region: SopE_GEF; pfam07487
439843005739	Protein of unknown function (DUF1398); Region: DUF1398; cl11576
439843005740	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
439843005741	Coenzyme A binding pocket [chemical binding]; other site
439843005742	Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495
439843005743	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
439843005744	Phage Tail Collar Domain; Region: Collar; pfam07484
439843005745	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
439843005746	Protein of unknown function (DUF1441); Region: DUF1441; pfam07278
439843005747	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
439843005748	exonuclease VIII; Reviewed; Region: PRK09709
439843005749	Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003
439843005750	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
439843005751	Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome.  They belong to the superfamily...; Region: INT_Lambda_C; cd00800
439843005752	dimer interface [polypeptide binding]; other site
439843005753	active site
439843005754	Int/Topo IB signature motif; other site
439843005755	Protein of unknown function (DUF2511); Region: DUF2511; pfam10709
439843005756	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
439843005757	hypothetical protein; Provisional; Region: PRK10301
439843005758	DNA polymerase III subunit theta; Reviewed; Region: PRK10969
439843005759	Predicted amidohydrolase [General function prediction only]; Region: COG0388
439843005760	Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795
439843005761	exodeoxyribonuclease X; Provisional; Region: PRK07983
439843005762	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
439843005763	active site
439843005764	catalytic site [active]
439843005765	substrate binding site [chemical binding]; other site
439843005766	protease 2; Provisional; Region: PRK10115
439843005767	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
439843005768	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979
439843005769	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
439843005770	putative metal binding site [ion binding]; other site
439843005771	hypothetical protein; Provisional; Region: PRK13680
439843005772	DNA damage-inducible protein YebG; Provisional; Region: PRK10061
439843005773	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
439843005774	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
439843005775	ATP-grasp domain; Region: ATP-grasp; pfam02222
439843005776	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
439843005777	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
439843005778	active site
439843005779	intersubunit interface [polypeptide binding]; other site
439843005780	catalytic residue [active]
439843005781	phosphogluconate dehydratase; Validated; Region: PRK09054
439843005782	6-phosphogluconate dehydratase; Region: edd; TIGR01196
439843005783	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
439843005784	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
439843005785	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
439843005786	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
439843005787	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
439843005788	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
439843005789	putative active site [active]
439843005790	pyruvate kinase; Provisional; Region: PRK05826
439843005791	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
439843005792	domain interfaces; other site
439843005793	active site
439843005794	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
439843005795	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
439843005796	putative acyl-acceptor binding pocket; other site
439843005797	putative peptidase; Provisional; Region: PRK11649
439843005798	Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525
439843005799	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
439843005800	Peptidase family M23; Region: Peptidase_M23; pfam01551
439843005801	high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545
439843005802	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
439843005803	metal binding site [ion binding]; metal-binding site
439843005804	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
439843005805	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
439843005806	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
439843005807	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
439843005808	ABC-ATPase subunit  interface; other site
439843005809	dimer interface [polypeptide binding]; other site
439843005810	putative PBP binding regions; other site
439843005811	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
439843005812	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439843005813	Walker A motif; other site
439843005814	ATP binding site [chemical binding]; other site
439843005815	Walker B motif; other site
439843005816	arginine finger; other site
439843005817	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
439843005818	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
439843005819	RuvA N terminal domain; Region: RuvA_N; pfam01330
439843005820	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
439843005821	hypothetical protein; Provisional; Region: PRK11470
439843005822	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
439843005823	active site
439843005824	putative DNA-binding cleft [nucleotide binding]; other site
439843005825	dimer interface [polypeptide binding]; other site
439843005826	hypothetical protein; Validated; Region: PRK00110
439843005827	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
439843005828	nudix motif; other site
439843005829	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
439843005830	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
439843005831	dimer interface [polypeptide binding]; other site
439843005832	anticodon binding site; other site
439843005833	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
439843005834	homodimer interface [polypeptide binding]; other site
439843005835	motif 1; other site
439843005836	active site
439843005837	motif 2; other site
439843005838	GAD domain; Region: GAD; pfam02938
439843005839	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
439843005840	active site
439843005841	motif 3; other site
439843005842	Isochorismatase family; Region: Isochorismatase; pfam00857
439843005843	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
439843005844	catalytic triad [active]
439843005845	conserved cis-peptide bond; other site
439843005846	hypothetical protein; Provisional; Region: PRK10302
439843005847	Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788
439843005848	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439843005849	S-adenosylmethionine binding site [chemical binding]; other site
439843005850	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439843005851	S-adenosylmethionine binding site [chemical binding]; other site
439843005852	copper homeostasis protein CutC; Provisional; Region: PRK11572
439843005853	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268
439843005854	putative metal binding site [ion binding]; other site
439843005855	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
439843005856	arginyl-tRNA synthetase; Region: argS; TIGR00456
439843005857	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
439843005858	active site
439843005859	HIGH motif; other site
439843005860	KMSK motif region; other site
439843005861	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
439843005862	tRNA binding surface [nucleotide binding]; other site
439843005863	anticodon binding site; other site
439843005864	penicillin-binding protein 2; Provisional; Region: PRK10795
439843005865	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
439843005866	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
439843005867	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
439843005868	Flagellar protein FlhE; Region: FlhE; pfam06366
439843005869	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
439843005870	FHIPEP family; Region: FHIPEP; pfam00771
439843005871	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
439843005872	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
439843005873	chemotaxis regulator CheZ; Provisional; Region: PRK11166
439843005874	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
439843005875	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843005876	active site
439843005877	phosphorylation site [posttranslational modification]
439843005878	intermolecular recognition site; other site
439843005879	dimerization interface [polypeptide binding]; other site
439843005880	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
439843005881	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843005882	active site
439843005883	phosphorylation site [posttranslational modification]
439843005884	intermolecular recognition site; other site
439843005885	dimerization interface [polypeptide binding]; other site
439843005886	CheB methylesterase; Region: CheB_methylest; pfam01339
439843005887	chemotaxis methyltransferase CheR; Provisional; Region: PRK10611
439843005888	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
439843005889	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439843005890	S-adenosylmethionine binding site [chemical binding]; other site
439843005891	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
439843005892	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
439843005893	dimer interface [polypeptide binding]; other site
439843005894	ligand binding site [chemical binding]; other site
439843005895	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
439843005896	dimerization interface [polypeptide binding]; other site
439843005897	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
439843005898	dimer interface [polypeptide binding]; other site
439843005899	putative CheW interface [polypeptide binding]; other site
439843005900	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
439843005901	putative CheA interaction surface; other site
439843005902	chemotaxis protein CheA; Provisional; Region: PRK10547
439843005903	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
439843005904	putative binding surface; other site
439843005905	active site
439843005906	CheY binding; Region: CheY-binding; pfam09078
439843005907	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
439843005908	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439843005909	ATP binding site [chemical binding]; other site
439843005910	Mg2+ binding site [ion binding]; other site
439843005911	G-X-G motif; other site
439843005912	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
439843005913	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
439843005914	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
439843005915	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
439843005916	ligand binding site [chemical binding]; other site
439843005917	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
439843005918	flagellar motor protein MotA; Validated; Region: PRK09110
439843005919	transcriptional activator FlhC; Provisional; Region: PRK12722
439843005920	transcriptional activator FlhD; Provisional; Region: PRK02909
439843005921	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
439843005922	Ligand Binding Site [chemical binding]; other site
439843005923	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
439843005924	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
439843005925	active site
439843005926	homotetramer interface [polypeptide binding]; other site
439843005927	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187
439843005928	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
439843005929	DJ-1 family protein; Region: not_thiJ; TIGR01383
439843005930	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
439843005931	conserved cys residue [active]
439843005932	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
439843005933	Ferritin-like domain; Region: Ferritin; pfam00210
439843005934	ferroxidase diiron center [ion binding]; other site
439843005935	hypothetical protein; Provisional; Region: PRK09273
439843005936	Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698
439843005937	Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408
439843005938	YecR-like lipoprotein; Region: YecR; pfam13992
439843005939	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
439843005940	Ferritin-like domain; Region: Ferritin; pfam00210
439843005941	ferroxidase diiron center [ion binding]; other site
439843005942	probable metal-binding protein; Region: matur_matur; TIGR03853
439843005943	tyrosine transporter TyrP; Provisional; Region: PRK15132
439843005944	aromatic amino acid transport protein; Region: araaP; TIGR00837
439843005945	hypothetical protein; Provisional; Region: PRK10396
439843005946	yecA family protein; Region: ygfB_yecA; TIGR02292
439843005947	SEC-C motif; Region: SEC-C; pfam02810
439843005948	glucose-6-phosphate 1-dehydrogenase; Region: PLN02640
439843005949	SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913
439843005950	SH3 domain of SH3b2 type; Region: SH3_7; pfam12914
439843005951	NlpC/P60 family; Region: NLPC_P60; cl17555
439843005952	phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832
439843005953	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
439843005954	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
439843005955	GIY-YIG motif/motif A; other site
439843005956	active site
439843005957	catalytic site [active]
439843005958	putative DNA binding site [nucleotide binding]; other site
439843005959	metal binding site [ion binding]; metal-binding site
439843005960	UvrB/uvrC motif; Region: UVR; pfam02151
439843005961	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
439843005962	Helix-hairpin-helix motif; Region: HHH; pfam00633
439843005963	response regulator; Provisional; Region: PRK09483
439843005964	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843005965	active site
439843005966	phosphorylation site [posttranslational modification]
439843005967	intermolecular recognition site; other site
439843005968	dimerization interface [polypeptide binding]; other site
439843005969	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
439843005970	DNA binding residues [nucleotide binding]
439843005971	dimerization interface [polypeptide binding]; other site
439843005972	hypothetical protein; Provisional; Region: PRK10613
439843005973	DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188
439843005974	Autoinducer binding domain; Region: Autoind_bind; pfam03472
439843005975	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
439843005976	DNA binding residues [nucleotide binding]
439843005977	dimerization interface [polypeptide binding]; other site
439843005978	putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264
439843005979	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
439843005980	Walker A/P-loop; other site
439843005981	ATP binding site [chemical binding]; other site
439843005982	Q-loop/lid; other site
439843005983	ABC transporter signature motif; other site
439843005984	Walker B; other site
439843005985	D-loop; other site
439843005986	H-loop/switch region; other site
439843005987	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
439843005988	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
439843005989	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843005990	dimer interface [polypeptide binding]; other site
439843005991	conserved gate region; other site
439843005992	putative PBP binding loops; other site
439843005993	ABC-ATPase subunit interface; other site
439843005994	D-cysteine desulfhydrase; Validated; Region: PRK03910
439843005995	Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449
439843005996	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843005997	catalytic residue [active]
439843005998	cystine transporter subunit; Provisional; Region: PRK11260
439843005999	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
439843006000	substrate binding pocket [chemical binding]; other site
439843006001	membrane-bound complex binding site; other site
439843006002	hinge residues; other site
439843006003	flagella biosynthesis protein FliZ; Provisional; Region: PRK11582
439843006004	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
439843006005	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
439843006006	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
439843006007	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
439843006008	DNA binding residues [nucleotide binding]
439843006009	flagellin; Validated; Region: PRK08026
439843006010	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
439843006011	Flagellin D3 domain; Region: Flagellin_D3; pfam08884
439843006012	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
439843006013	flagellar capping protein; Reviewed; Region: fliD; PRK08032
439843006014	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
439843006015	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
439843006016	flagellar protein FliS; Validated; Region: fliS; PRK05685
439843006017	flagellar biosynthesis protein FliT; Provisional; Region: PRK10548
439843006018	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
439843006019	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
439843006020	active site
439843006021	Na/Ca binding site [ion binding]; other site
439843006022	catalytic site [active]
439843006023	lipoprotein; Provisional; Region: PRK10397
439843006024	putative inner membrane protein; Provisional; Region: PRK11099
439843006025	Sulphur transport; Region: Sulf_transp; pfam04143
439843006026	YedF is a bacterial SirA-like protein of unknown function.  SirA  (also known as UvrY,  and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422
439843006027	CPxP  motif; other site
439843006028	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253
439843006029	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
439843006030	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
439843006031	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
439843006032	flagellar motor switch protein FliG; Region: fliG; TIGR00207
439843006033	FliG C-terminal domain; Region: FliG_C; pfam01706
439843006034	flagellar assembly protein H; Validated; Region: fliH; PRK05687
439843006035	Flagellar assembly protein FliH; Region: FliH; pfam02108
439843006036	flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960
439843006037	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
439843006038	Walker A motif/ATP binding site; other site
439843006039	Walker B motif; other site
439843006040	Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882
439843006041	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
439843006042	flagellar hook-length control protein; Provisional; Region: PRK10118
439843006043	Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144
439843006044	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021
439843006045	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
439843006046	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
439843006047	flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963
439843006048	flagellar motor switch protein; Validated; Region: fliN; PRK05698
439843006049	flagellar biosynthesis protein FliO; Provisional; Region: PRK11486
439843006050	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
439843006051	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
439843006052	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
439843006053	colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411
439843006054	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
439843006055	DNA binding residues [nucleotide binding]
439843006056	dimerization interface [polypeptide binding]; other site
439843006057	hypothetical protein; Provisional; Region: PRK10708
439843006058	Protein of unknown function (DUF2525); Region: DUF2525; pfam10733
439843006059	mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669
439843006060	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439843006061	active site
439843006062	motif I; other site
439843006063	motif II; other site
439843006064	putative diguanylate cyclase YedQ; Provisional; Region: PRK15426
439843006065	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
439843006066	metal binding site [ion binding]; metal-binding site
439843006067	active site
439843006068	I-site; other site
439843006069	Uncharacterized small protein [Function unknown]; Region: COG5475
439843006070	hypothetical protein; Provisional; Region: PRK10062
439843006071	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
439843006072	EamA-like transporter family; Region: EamA; pfam00892
439843006073	EamA-like transporter family; Region: EamA; pfam00892
439843006074	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
439843006075	additional DNA contacts [nucleotide binding]; other site
439843006076	mismatch recognition site; other site
439843006077	active site
439843006078	zinc binding site [ion binding]; other site
439843006079	DNA intercalation site [nucleotide binding]; other site
439843006080	DNA cytosine methylase; Provisional; Region: PRK10458
439843006081	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
439843006082	cofactor binding site; other site
439843006083	DNA binding site [nucleotide binding]
439843006084	substrate interaction site [chemical binding]; other site
439843006085	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
439843006086	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
439843006087	Zn2+ binding site [ion binding]; other site
439843006088	Mg2+ binding site [ion binding]; other site
439843006089	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
439843006090	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
439843006091	trimer interface [polypeptide binding]; other site
439843006092	eyelet of channel; other site
439843006093	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
439843006094	DNA-binding site [nucleotide binding]; DNA binding site
439843006095	RNA-binding motif; other site
439843006096	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
439843006097	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
439843006098	active site
439843006099	DNA binding site [nucleotide binding]
439843006100	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
439843006101	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
439843006102	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
439843006103	Catalytic site [active]
439843006104	DgsA anti-repressor MtfA; Provisional; Region: PRK15410
439843006105	AMP nucleosidase; Provisional; Region: PRK08292
439843006106	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
439843006107	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
439843006108	Protein of unknown function (DUF1493); Region: DUF1493; pfam07377
439843006109	MATE family multidrug exporter; Provisional; Region: PRK10189
439843006110	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
439843006111	Transcriptional regulator [Transcription]; Region: LysR; COG0583
439843006112	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843006113	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
439843006114	dimerization interface [polypeptide binding]; other site
439843006115	glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425
439843006116	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
439843006117	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
439843006118	EamA-like transporter family; Region: EamA; cl17759
439843006119	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
439843006120	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
439843006121	active site
439843006122	AMP binding site [chemical binding]; other site
439843006123	acyl-activating enzyme (AAE) consensus motif; other site
439843006124	CoA binding site [chemical binding]; other site
439843006125	Orn/Lys/Arg decarboxylase, major domain; Region: OKR_DC_1; pfam01276
439843006126	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
439843006127	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
439843006128	catalytic residue [active]
439843006129	L,D-transpeptidase; Provisional; Region: PRK10190
439843006130	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
439843006131	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
439843006132	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
439843006133	putative dimer interface [polypeptide binding]; other site
439843006134	active site pocket [active]
439843006135	putative cataytic base [active]
439843006136	cobalamin synthase; Reviewed; Region: cobS; PRK00235
439843006137	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
439843006138	homotrimer interface [polypeptide binding]; other site
439843006139	Walker A motif; other site
439843006140	GTP binding site [chemical binding]; other site
439843006141	Walker B motif; other site
439843006142	cobyric acid synthase; Provisional; Region: PRK00784
439843006143	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
439843006144	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
439843006145	catalytic triad [active]
439843006146	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638
439843006147	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
439843006148	Walker A/P-loop; other site
439843006149	ATP binding site [chemical binding]; other site
439843006150	Q-loop/lid; other site
439843006151	ABC transporter signature motif; other site
439843006152	Walker B; other site
439843006153	D-loop; other site
439843006154	H-loop/switch region; other site
439843006155	cobalt transport protein CbiQ; Provisional; Region: PRK15485
439843006156	cobalt transport protein CbiN; Provisional; Region: PRK02898
439843006157	cobalt transport protein CbiM; Validated; Region: PRK08319
439843006158	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
439843006159	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
439843006160	active site
439843006161	SAM binding site [chemical binding]; other site
439843006162	homodimer interface [polypeptide binding]; other site
439843006163	Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822
439843006164	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412
439843006165	active site
439843006166	C-terminal domain interface [polypeptide binding]; other site
439843006167	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
439843006168	active site
439843006169	N-terminal domain interface [polypeptide binding]; other site
439843006170	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
439843006171	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
439843006172	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
439843006173	active site
439843006174	SAM binding site [chemical binding]; other site
439843006175	homodimer interface [polypeptide binding]; other site
439843006176	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
439843006177	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
439843006178	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
439843006179	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
439843006180	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
439843006181	active site
439843006182	SAM binding site [chemical binding]; other site
439843006183	homodimer interface [polypeptide binding]; other site
439843006184	cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287
439843006185	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439843006186	S-adenosylmethionine binding site [chemical binding]; other site
439843006187	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
439843006188	active site
439843006189	putative homodimer interface [polypeptide binding]; other site
439843006190	SAM binding site [chemical binding]; other site
439843006191	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
439843006192	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286
439843006193	Precorrin-8X methylmutase; Region: CbiC; pfam02570
439843006194	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
439843006195	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
439843006196	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
439843006197	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
439843006198	catalytic triad [active]
439843006199	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
439843006200	Sensory domain found in PocR; Region: PocR; pfam10114
439843006201	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439843006202	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
439843006203	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439843006204	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
439843006205	amphipathic channel; other site
439843006206	Asn-Pro-Ala signature motifs; other site
439843006207	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
439843006208	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
439843006209	Hexamer interface [polypeptide binding]; other site
439843006210	Putative hexagonal pore residue; other site
439843006211	propanediol utilization protein PduB; Provisional; Region: PRK15415
439843006212	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047
439843006213	putative hexamer interface [polypeptide binding]; other site
439843006214	putative hexagonal pore; other site
439843006215	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048
439843006216	putative hexamer interface [polypeptide binding]; other site
439843006217	putative hexagonal pore; other site
439843006218	Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909
439843006219	Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687
439843006220	alpha-alpha subunit/dimer interface [polypeptide binding]; other site
439843006221	alpha-beta subunit interface [polypeptide binding]; other site
439843006222	alpha-gamma subunit interface [polypeptide binding]; other site
439843006223	active site
439843006224	substrate and K+ binding site; other site
439843006225	K+ binding site [ion binding]; other site
439843006226	cobalamin binding site [chemical binding]; other site
439843006227	propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042
439843006228	Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910
439843006229	Cell division protein FtsA; Region: FtsA; cl17206
439843006230	Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841
439843006231	Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288
439843006232	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
439843006233	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
439843006234	Hexamer interface [polypeptide binding]; other site
439843006235	Putative hexagonal pore residue; other site
439843006236	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
439843006237	1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056
439843006238	putative hexamer interface [polypeptide binding]; other site
439843006239	putative hexagonal pore; other site
439843006240	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
439843006241	Propanediol utilisation protein PduL; Region: PduL; pfam06130
439843006242	Propanediol utilisation protein PduL; Region: PduL; pfam06130
439843006243	putative propanediol utilization protein PduM; Provisional; Region: PRK15428
439843006244	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
439843006245	Hexamer/Pentamer interface [polypeptide binding]; other site
439843006246	central pore; other site
439843006247	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
439843006248	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
439843006249	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
439843006250	putative catalytic cysteine [active]
439843006251	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
439843006252	1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180
439843006253	putative active site [active]
439843006254	metal binding site [ion binding]; metal-binding site
439843006255	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
439843006256	SLBB domain; Region: SLBB; pfam10531
439843006257	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
439843006258	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
439843006259	PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526
439843006260	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
439843006261	putative hexamer interface [polypeptide binding]; other site
439843006262	putative hexagonal pore; other site
439843006263	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
439843006264	putative hexamer interface [polypeptide binding]; other site
439843006265	putative hexagonal pore; other site
439843006266	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
439843006267	putative hexamer interface [polypeptide binding]; other site
439843006268	putative hexagonal pore; other site
439843006269	Ethanolamine utilisation - propanediol utilisation; Region: PduV-EutP; pfam10662
439843006270	G3 box; other site
439843006271	Switch II region; other site
439843006272	GTP/Mg2+ binding site [chemical binding]; other site
439843006273	G4 box; other site
439843006274	G5 box; other site
439843006275	propionate kinase; Reviewed; Region: PRK12397
439843006276	propionate/acetate kinase; Provisional; Region: PRK12379
439843006277	Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542
439843006278	hypothetical protein; Provisional; Region: PRK05423
439843006279	Predicted membrane protein [Function unknown]; Region: COG1289
439843006280	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
439843006281	DNA gyrase inhibitor; Provisional; Region: PRK10016
439843006282	D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397
439843006283	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
439843006284	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
439843006285	thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006
439843006286	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
439843006287	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
439843006288	4Fe-4S binding domain; Region: Fer4; cl02805
439843006289	thiosulfate reductase PhsA; Provisional; Region: PRK15488
439843006290	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
439843006291	The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755
439843006292	putative [Fe4-S4] binding site [ion binding]; other site
439843006293	putative molybdopterin cofactor binding site [chemical binding]; other site
439843006294	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
439843006295	The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778
439843006296	putative molybdopterin cofactor binding site; other site
439843006297	E3 ubiquitin-protein ligase SopA; Provisional; Region: PRK15377
439843006298	SopA-like central domain; Region: SopA; pfam13981
439843006299	SopA-like catalytic domain; Region: SopA_C; pfam13979
439843006300	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
439843006301	Protein of unknown function (DUF1353); Region: DUF1353; pfam07087
439843006302	Acyltransferase family; Region: Acyl_transf_3; pfam01757
439843006303	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
439843006304	Phage-related tail fibre protein [General function prediction only]; Region: COG5301
439843006305	Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076
439843006306	Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299
439843006307	Phage protein GP46; Region: GP46; pfam07409
439843006308	Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; pfam06890
439843006309	Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379
439843006310	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
439843006311	Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228
439843006312	DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157
439843006313	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
439843006314	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
439843006315	Phage tail tube protein; Region: Tail_tube; pfam10618
439843006316	Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386
439843006317	Phage tail sheath protein; Region: Phage_sheath_1; pfam04984
439843006318	Protein of unknown function (DUF2635); Region: DUF2635; pfam10948
439843006319	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
439843006320	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
439843006321	oligomerization interface [polypeptide binding]; other site
439843006322	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
439843006323	Phage capsid family; Region: Phage_capsid; pfam05065
439843006324	Caudovirus prohead protease; Region: Peptidase_U35; cl01521
439843006325	Phage-related protein [Function unknown]; Region: COG4695
439843006326	Phage portal protein; Region: Phage_portal; pfam04860
439843006327	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
439843006328	Phage terminase, small subunit; Region: Terminase_4; pfam05119
439843006329	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
439843006330	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
439843006331	active site
439843006332	Predicted chitinase [General function prediction only]; Region: COG3179
439843006333	catalytic residue [active]
439843006334	Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938
439843006335	Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323
439843006336	Bacteriophage Lambda NinG protein; Region: NinG; pfam05766
439843006337	Protein of unknown function (DUF1367); Region: DUF1367; pfam07105
439843006338	DinI-like family; Region: DinI; pfam06183
439843006339	Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935
439843006340	Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163
439843006341	putative replication protein; Provisional; Region: PRK12377
439843006342	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439843006343	Walker A motif; other site
439843006344	ATP binding site [chemical binding]; other site
439843006345	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
439843006346	Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492
439843006347	primosomal protein DnaI; Provisional; Region: PRK02854
439843006348	Bacteriophage CII protein; Region: Phage_CII; pfam05269
439843006349	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
439843006350	non-specific DNA binding site [nucleotide binding]; other site
439843006351	salt bridge; other site
439843006352	sequence-specific DNA binding site [nucleotide binding]; other site
439843006353	Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630
439843006354	exonuclease VIII; Reviewed; Region: PRK09709
439843006355	PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684
439843006356	RecT family; Region: RecT; pfam03837
439843006357	Protein of unknown function (DUF4060); Region: DUF4060; pfam13269
439843006358	integrase; Provisional; Region: PRK09692
439843006359	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
439843006360	active site
439843006361	Int/Topo IB signature motif; other site
439843006362	exonuclease I; Provisional; Region: sbcB; PRK11779
439843006363	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
439843006364	active site
439843006365	catalytic site [active]
439843006366	substrate binding site [chemical binding]; other site
439843006367	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
439843006368	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
439843006369	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843006370	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
439843006371	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
439843006372	dimerization interface [polypeptide binding]; other site
439843006373	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
439843006374	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
439843006375	putative NAD(P) binding site [chemical binding]; other site
439843006376	Histidine operon leader
439843006377	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
439843006378	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
439843006379	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
439843006380	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
439843006381	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
439843006382	NAD binding site [chemical binding]; other site
439843006383	dimerization interface [polypeptide binding]; other site
439843006384	product binding site; other site
439843006385	substrate binding site [chemical binding]; other site
439843006386	zinc binding site [ion binding]; other site
439843006387	catalytic residues [active]
439843006388	histidinol-phosphate aminotransferase; Provisional; Region: PRK01688
439843006389	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
439843006390	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843006391	homodimer interface [polypeptide binding]; other site
439843006392	catalytic residue [active]
439843006393	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
439843006394	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439843006395	active site
439843006396	motif I; other site
439843006397	motif II; other site
439843006398	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
439843006399	putative active site pocket [active]
439843006400	4-fold oligomerization interface [polypeptide binding]; other site
439843006401	metal binding residues [ion binding]; metal-binding site
439843006402	3-fold/trimer interface [polypeptide binding]; other site
439843006403	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170
439843006404	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
439843006405	putative active site [active]
439843006406	oxyanion strand; other site
439843006407	catalytic triad [active]
439843006408	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
439843006409	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
439843006410	catalytic residues [active]
439843006411	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
439843006412	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
439843006413	substrate binding site [chemical binding]; other site
439843006414	glutamase interaction surface [polypeptide binding]; other site
439843006415	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
439843006416	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
439843006417	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
439843006418	metal binding site [ion binding]; metal-binding site
439843006419	chain length determinant protein WzzB; Provisional; Region: PRK15471
439843006420	Chain length determinant protein; Region: Wzz; cl15801
439843006421	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
439843006422	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
439843006423	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
439843006424	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
439843006425	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
439843006426	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
439843006427	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
439843006428	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
439843006429	undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204
439843006430	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
439843006431	Bacterial sugar transferase; Region: Bac_transf; pfam02397
439843006432	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
439843006433	ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088
439843006434	active site
439843006435	substrate binding site [chemical binding]; other site
439843006436	metal binding site [ion binding]; metal-binding site
439843006437	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
439843006438	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
439843006439	Substrate binding site; other site
439843006440	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
439843006441	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
439843006442	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
439843006443	active site
439843006444	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
439843006445	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
439843006446	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
439843006447	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
439843006448	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
439843006449	active site
439843006450	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
439843006451	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082
439843006452	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
439843006453	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
439843006454	NAD(P) binding site [chemical binding]; other site
439843006455	active site
439843006456	lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407
439843006457	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
439843006458	inhibitor-cofactor binding pocket; inhibition site
439843006459	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843006460	catalytic residue [active]
439843006461	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
439843006462	CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252
439843006463	NAD binding site [chemical binding]; other site
439843006464	homotetramer interface [polypeptide binding]; other site
439843006465	homodimer interface [polypeptide binding]; other site
439843006466	substrate binding site [chemical binding]; other site
439843006467	active site
439843006468	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
439843006469	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
439843006470	substrate binding site; other site
439843006471	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
439843006472	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
439843006473	catalytic loop [active]
439843006474	iron binding site [ion binding]; other site
439843006475	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
439843006476	FAD binding pocket [chemical binding]; other site
439843006477	FAD binding motif [chemical binding]; other site
439843006478	phosphate binding motif [ion binding]; other site
439843006479	beta-alpha-beta structure motif; other site
439843006480	NAD binding pocket [chemical binding]; other site
439843006481	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
439843006482	glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480
439843006483	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
439843006484	substrate binding site; other site
439843006485	tetramer interface; other site
439843006486	dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987
439843006487	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
439843006488	NADP binding site [chemical binding]; other site
439843006489	active site
439843006490	putative substrate binding site [chemical binding]; other site
439843006491	dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084
439843006492	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
439843006493	NAD binding site [chemical binding]; other site
439843006494	substrate binding site [chemical binding]; other site
439843006495	homodimer interface [polypeptide binding]; other site
439843006496	active site
439843006497	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
439843006498	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
439843006499	active site
439843006500	tetramer interface; other site
439843006501	colanic acid biosynthesis protein WcaM; Region: WcaM; TIGR04004
439843006502	colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427
439843006503	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
439843006504	putative ADP-binding pocket [chemical binding]; other site
439843006505	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
439843006506	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
439843006507	colanic acid exporter; Provisional; Region: PRK10459
439843006508	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
439843006509	putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124
439843006510	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
439843006511	phosphomannomutase CpsG; Provisional; Region: PRK15414
439843006512	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
439843006513	active site
439843006514	substrate binding site [chemical binding]; other site
439843006515	metal binding site [ion binding]; metal-binding site
439843006516	mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460
439843006517	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
439843006518	Substrate binding site; other site
439843006519	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
439843006520	colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007
439843006521	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
439843006522	GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430
439843006523	active site
439843006524	GDP-Mannose binding site [chemical binding]; other site
439843006525	dimer interface [polypeptide binding]; other site
439843006526	modified nudix motif
439843006527	metal binding site [ion binding]; metal-binding site
439843006528	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
439843006529	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
439843006530	NADP binding site [chemical binding]; other site
439843006531	active site
439843006532	putative substrate binding site [chemical binding]; other site
439843006533	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
439843006534	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
439843006535	NADP-binding site; other site
439843006536	homotetramer interface [polypeptide binding]; other site
439843006537	substrate binding site [chemical binding]; other site
439843006538	homodimer interface [polypeptide binding]; other site
439843006539	active site
439843006540	colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008
439843006541	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
439843006542	putative trimer interface [polypeptide binding]; other site
439843006543	putative active site [active]
439843006544	putative substrate binding site [chemical binding]; other site
439843006545	putative CoA binding site [chemical binding]; other site
439843006546	putative glycosyl transferase; Provisional; Region: PRK10063
439843006547	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
439843006548	metal-binding site
439843006549	putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010
439843006550	colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015
439843006551	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
439843006552	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
439843006553	putative acyl transferase; Provisional; Region: PRK10191
439843006554	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
439843006555	trimer interface [polypeptide binding]; other site
439843006556	active site
439843006557	substrate binding site [chemical binding]; other site
439843006558	CoA binding site [chemical binding]; other site
439843006559	putative glycosyl transferase; Provisional; Region: PRK10018
439843006560	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
439843006561	active site
439843006562	tyrosine kinase; Provisional; Region: PRK11519
439843006563	Chain length determinant protein; Region: Wzz; pfam02706
439843006564	Chain length determinant protein; Region: Wzz; cl15801
439843006565	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
439843006566	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
439843006567	Low molecular weight phosphatase family; Region: LMWPc; cd00115
439843006568	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
439843006569	active site
439843006570	polysaccharide export protein Wza; Provisional; Region: PRK15078
439843006571	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
439843006572	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
439843006573	FOG: CBS domain [General function prediction only]; Region: COG0517
439843006574	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
439843006575	Transporter associated domain; Region: CorC_HlyC; smart01091
439843006576	putative assembly protein; Provisional; Region: PRK10833
439843006577	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
439843006578	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
439843006579	trimer interface [polypeptide binding]; other site
439843006580	active site
439843006581	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
439843006582	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
439843006583	ATP-binding site [chemical binding]; other site
439843006584	Sugar specificity; other site
439843006585	Pyrimidine base specificity; other site
439843006586	Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447
439843006587	PAS domain S-box; Region: sensory_box; TIGR00229
439843006588	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
439843006589	putative active site [active]
439843006590	heme pocket [chemical binding]; other site
439843006591	PAS domain S-box; Region: sensory_box; TIGR00229
439843006592	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
439843006593	putative active site [active]
439843006594	heme pocket [chemical binding]; other site
439843006595	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
439843006596	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
439843006597	metal binding site [ion binding]; metal-binding site
439843006598	active site
439843006599	I-site; other site
439843006600	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
439843006601	3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308
439843006602	AlkA N-terminal domain; Region: AlkA_N; pfam06029
439843006603	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
439843006604	minor groove reading motif; other site
439843006605	helix-hairpin-helix signature motif; other site
439843006606	substrate binding pocket [chemical binding]; other site
439843006607	active site
439843006608	putative chaperone; Provisional; Region: PRK11678
439843006609	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
439843006610	nucleotide binding site [chemical binding]; other site
439843006611	putative NEF/HSP70 interaction site [polypeptide binding]; other site
439843006612	SBD interface [polypeptide binding]; other site
439843006613	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
439843006614	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
439843006615	HlyD family secretion protein; Region: HlyD_3; pfam13437
439843006616	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
439843006617	Protein export membrane protein; Region: SecD_SecF; cl14618
439843006618	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
439843006619	putative transporter; Provisional; Region: PRK10504
439843006620	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843006621	putative substrate translocation pore; other site
439843006622	signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549
439843006623	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
439843006624	dimerization interface [polypeptide binding]; other site
439843006625	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439843006626	dimer interface [polypeptide binding]; other site
439843006627	phosphorylation site [posttranslational modification]
439843006628	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439843006629	ATP binding site [chemical binding]; other site
439843006630	Mg2+ binding site [ion binding]; other site
439843006631	G-X-G motif; other site
439843006632	DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710
439843006633	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843006634	active site
439843006635	phosphorylation site [posttranslational modification]
439843006636	intermolecular recognition site; other site
439843006637	dimerization interface [polypeptide binding]; other site
439843006638	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
439843006639	DNA binding site [nucleotide binding]
439843006640	PcfJ-like protein; Region: PcfJ; pfam14284
439843006641	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
439843006642	Domain of unknown function (DUF4034); Region: DUF4034; pfam13226
439843006643	putative protease; Provisional; Region: PRK15452
439843006644	Peptidase family U32; Region: Peptidase_U32; pfam01136
439843006645	Tir chaperone protein (CesT) family; Region: CesT; pfam05932
439843006646	lipid kinase; Reviewed; Region: PRK13054
439843006647	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
439843006648	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
439843006649	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
439843006650	putative active site; other site
439843006651	catalytic residue [active]
439843006652	nucleoside transporter; Region: 2A0110; TIGR00889
439843006653	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843006654	putative substrate translocation pore; other site
439843006655	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
439843006656	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
439843006657	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
439843006658	substrate binding site [chemical binding]; other site
439843006659	ATP binding site [chemical binding]; other site
439843006660	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
439843006661	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439843006662	DNA-binding site [nucleotide binding]; DNA binding site
439843006663	UTRA domain; Region: UTRA; pfam07702
439843006664	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
439843006665	dimer interface [polypeptide binding]; other site
439843006666	substrate binding site [chemical binding]; other site
439843006667	ATP binding site [chemical binding]; other site
439843006668	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
439843006669	substrate binding site [chemical binding]; other site
439843006670	multimerization interface [polypeptide binding]; other site
439843006671	ATP binding site [chemical binding]; other site
439843006672	Predicted integral membrane protein [Function unknown]; Region: COG5455
439843006673	putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216
439843006674	putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252
439843006675	fimbrial outer membrane usher protein; Provisional; Region: PRK15217
439843006676	PapC N-terminal domain; Region: PapC_N; pfam13954
439843006677	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
439843006678	PapC C-terminal domain; Region: PapC_C; pfam13953
439843006679	fimbrial chaperone protein PegB; Provisional; Region: PRK15218
439843006680	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
439843006681	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
439843006682	fimbrial chaperone protein; Provisional; Region: PRK15220
439843006683	Protein of unknown function (DUF2574); Region: DUF2574; pfam10836
439843006684	antiporter inner membrane protein; Provisional; Region: PRK11670
439843006685	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
439843006686	Walker A motif; other site
439843006687	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
439843006688	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
439843006689	active site
439843006690	HIGH motif; other site
439843006691	KMSKS motif; other site
439843006692	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
439843006693	tRNA binding surface [nucleotide binding]; other site
439843006694	anticodon binding site; other site
439843006695	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
439843006696	dimer interface [polypeptide binding]; other site
439843006697	putative tRNA-binding site [nucleotide binding]; other site
439843006698	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
439843006699	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
439843006700	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
439843006701	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
439843006702	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
439843006703	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
439843006704	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843006705	active site
439843006706	phosphorylation site [posttranslational modification]
439843006707	intermolecular recognition site; other site
439843006708	dimerization interface [polypeptide binding]; other site
439843006709	LytTr DNA-binding domain; Region: LytTR; pfam04397
439843006710	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
439843006711	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
439843006712	GAF domain; Region: GAF; pfam01590
439843006713	Histidine kinase; Region: His_kinase; pfam06580
439843006714	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439843006715	ATP binding site [chemical binding]; other site
439843006716	Mg2+ binding site [ion binding]; other site
439843006717	G-X-G motif; other site
439843006718	transcriptional regulator MirA; Provisional; Region: PRK15043
439843006719	Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763
439843006720	DNA binding residues [nucleotide binding]
439843006721	ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174
439843006722	putative PBP binding loops; other site
439843006723	ABC-ATPase subunit interface; other site
439843006724	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
439843006725	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
439843006726	Walker A/P-loop; other site
439843006727	ATP binding site [chemical binding]; other site
439843006728	Q-loop/lid; other site
439843006729	ABC transporter signature motif; other site
439843006730	Walker B; other site
439843006731	D-loop; other site
439843006732	H-loop/switch region; other site
439843006733	CBS domain; Region: CBS; pfam00571
439843006734	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843006735	dimer interface [polypeptide binding]; other site
439843006736	conserved gate region; other site
439843006737	ABC-ATPase subunit interface; other site
439843006738	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
439843006739	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
439843006740	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
439843006741	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
439843006742	D-lactate dehydrogenase; Provisional; Region: PRK11183
439843006743	FAD binding domain; Region: FAD_binding_4; pfam01565
439843006744	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
439843006745	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
439843006746	D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669
439843006747	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
439843006748	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
439843006749	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
439843006750	oxidoreductase; Provisional; Region: PRK12743
439843006751	classical (c) SDRs; Region: SDR_c; cd05233
439843006752	NAD(P) binding site [chemical binding]; other site
439843006753	active site
439843006754	multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459
439843006755	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
439843006756	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
439843006757	FMN binding site [chemical binding]; other site
439843006758	active site
439843006759	catalytic residues [active]
439843006760	substrate binding site [chemical binding]; other site
439843006761	salicylate hydroxylase; Provisional; Region: PRK08163
439843006762	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
439843006763	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
439843006764	maleylacetoacetate isomerase; Region: maiA; TIGR01262
439843006765	C-terminal domain interface [polypeptide binding]; other site
439843006766	GSH binding site (G-site) [chemical binding]; other site
439843006767	putative dimer interface [polypeptide binding]; other site
439843006768	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
439843006769	dimer interface [polypeptide binding]; other site
439843006770	N-terminal domain interface [polypeptide binding]; other site
439843006771	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
439843006772	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
439843006773	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
439843006774	gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272
439843006775	Cupin domain; Region: Cupin_2; pfam07883
439843006776	Cupin domain; Region: Cupin_2; pfam07883
439843006777	benzoate transport; Region: 2A0115; TIGR00895
439843006778	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843006779	putative substrate translocation pore; other site
439843006780	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
439843006781	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843006782	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
439843006783	dimerization interface [polypeptide binding]; other site
439843006784	hypothetical protein; Provisional; Region: PRK01821
439843006785	hypothetical protein; Provisional; Region: PRK10711
439843006786	cytidine deaminase; Provisional; Region: PRK09027
439843006787	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
439843006788	active site
439843006789	catalytic motif [active]
439843006790	Zn binding site [ion binding]; other site
439843006791	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
439843006792	active site
439843006793	catalytic motif [active]
439843006794	Zn binding site [ion binding]; other site
439843006795	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
439843006796	putative active site [active]
439843006797	Protein of unknown function (DUF2542); Region: DUF2542; pfam10808
439843006798	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
439843006799	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
439843006800	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
439843006801	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
439843006802	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
439843006803	homodimer interface [polypeptide binding]; other site
439843006804	active site
439843006805	FMN binding site [chemical binding]; other site
439843006806	substrate binding site [chemical binding]; other site
439843006807	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
439843006808	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
439843006809	TM-ABC transporter signature motif; other site
439843006810	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
439843006811	galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982
439843006812	Walker A/P-loop; other site
439843006813	ATP binding site [chemical binding]; other site
439843006814	Q-loop/lid; other site
439843006815	ABC transporter signature motif; other site
439843006816	Walker B; other site
439843006817	D-loop; other site
439843006818	H-loop/switch region; other site
439843006819	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
439843006820	methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395
439843006821	Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539
439843006822	ligand binding site [chemical binding]; other site
439843006823	calcium binding site [ion binding]; other site
439843006824	DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401
439843006825	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
439843006826	DNA binding site [nucleotide binding]
439843006827	domain linker motif; other site
439843006828	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
439843006829	dimerization interface (closed form) [polypeptide binding]; other site
439843006830	ligand binding site [chemical binding]; other site
439843006831	Predicted membrane protein [Function unknown]; Region: COG2311
439843006832	hypothetical protein; Provisional; Region: PRK10835
439843006833	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
439843006834	GTP cyclohydrolase I; Provisional; Region: PLN03044
439843006835	active site
439843006836	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
439843006837	S-formylglutathione hydrolase; Region: PLN02442
439843006838	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
439843006839	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
439843006840	non-specific DNA binding site [nucleotide binding]; other site
439843006841	salt bridge; other site
439843006842	sequence-specific DNA binding site [nucleotide binding]; other site
439843006843	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
439843006844	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
439843006845	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
439843006846	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
439843006847	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
439843006848	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439843006849	motif II; other site
439843006850	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
439843006851	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843006852	putative substrate translocation pore; other site
439843006853	catecholate siderophore receptor CirA; Provisional; Region: PRK10064
439843006854	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
439843006855	N-terminal plug; other site
439843006856	ligand-binding site [chemical binding]; other site
439843006857	lysine transporter; Provisional; Region: PRK10836
439843006858	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
439843006859	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843006860	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
439843006861	putative dimerization interface [polypeptide binding]; other site
439843006862	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
439843006863	endonuclease IV; Provisional; Region: PRK01060
439843006864	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
439843006865	AP (apurinic/apyrimidinic) site pocket; other site
439843006866	DNA interaction; other site
439843006867	Metal-binding active site; metal-binding site
439843006868	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
439843006869	N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925
439843006870	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
439843006871	active site
439843006872	P-loop; other site
439843006873	phosphorylation site [posttranslational modification]
439843006874	PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427
439843006875	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
439843006876	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
439843006877	putative substrate binding site [chemical binding]; other site
439843006878	putative ATP binding site [chemical binding]; other site
439843006879	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109
439843006880	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
439843006881	active site
439843006882	phosphorylation site [posttranslational modification]
439843006883	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
439843006884	dimerization domain swap beta strand [polypeptide binding]; other site
439843006885	regulatory protein interface [polypeptide binding]; other site
439843006886	active site
439843006887	regulatory phosphorylation site [posttranslational modification]; other site
439843006888	sugar efflux transporter B; Provisional; Region: PRK15011
439843006889	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843006890	putative substrate translocation pore; other site
439843006891	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
439843006892	Flagellin N-methylase; Region: FliB; cl00497
439843006893	elongation factor P; Provisional; Region: PRK04542
439843006894	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
439843006895	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
439843006896	RNA binding site [nucleotide binding]; other site
439843006897	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
439843006898	RNA binding site [nucleotide binding]; other site
439843006899	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
439843006900	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
439843006901	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
439843006902	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
439843006903	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
439843006904	active site
439843006905	outer membrane lipoprotein; Provisional; Region: spr; PRK10838
439843006906	NlpC/P60 family; Region: NLPC_P60; pfam00877
439843006907	phage resistance protein; Provisional; Region: PRK10551
439843006908	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
439843006909	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
439843006910	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
439843006911	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
439843006912	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
439843006913	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843006914	dimer interface [polypeptide binding]; other site
439843006915	conserved gate region; other site
439843006916	putative PBP binding loops; other site
439843006917	ABC-ATPase subunit interface; other site
439843006918	microcin C ABC transporter permease; Provisional; Region: PRK15021
439843006919	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843006920	dimer interface [polypeptide binding]; other site
439843006921	conserved gate region; other site
439843006922	ABC-ATPase subunit interface; other site
439843006923	microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134
439843006924	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
439843006925	Walker A/P-loop; other site
439843006926	ATP binding site [chemical binding]; other site
439843006927	Q-loop/lid; other site
439843006928	ABC transporter signature motif; other site
439843006929	Walker B; other site
439843006930	D-loop; other site
439843006931	H-loop/switch region; other site
439843006932	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
439843006933	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
439843006934	Walker A/P-loop; other site
439843006935	ATP binding site [chemical binding]; other site
439843006936	Q-loop/lid; other site
439843006937	ABC transporter signature motif; other site
439843006938	Walker B; other site
439843006939	D-loop; other site
439843006940	H-loop/switch region; other site
439843006941	hypothetical protein; Provisional; Region: PRK11835
439843006942	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843006943	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
439843006944	putative substrate translocation pore; other site
439843006945	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
439843006946	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
439843006947	RNA binding surface [nucleotide binding]; other site
439843006948	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
439843006949	active site
439843006950	uracil binding [chemical binding]; other site
439843006951	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
439843006952	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
439843006953	ATP binding site [chemical binding]; other site
439843006954	putative Mg++ binding site [ion binding]; other site
439843006955	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
439843006956	nucleotide binding region [chemical binding]; other site
439843006957	ATP-binding site [chemical binding]; other site
439843006958	Ribosomal L40e family; Region: Ribosomal_L40e; cl00671
439843006959	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
439843006960	5S rRNA interface [nucleotide binding]; other site
439843006961	CTC domain interface [polypeptide binding]; other site
439843006962	L16 interface [polypeptide binding]; other site
439843006963	Nucleoid-associated protein [General function prediction only]; Region: COG3081
439843006964	nucleoid-associated protein NdpA; Validated; Region: PRK00378
439843006965	hypothetical protein; Provisional; Region: PRK13689
439843006966	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
439843006967	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
439843006968	Sulfatase; Region: Sulfatase; cl17466
439843006969	DinI-like family; Region: DinI; cl11630
439843006970	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
439843006971	transcriptional regulator NarP; Provisional; Region: PRK10403
439843006972	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843006973	active site
439843006974	phosphorylation site [posttranslational modification]
439843006975	intermolecular recognition site; other site
439843006976	dimerization interface [polypeptide binding]; other site
439843006977	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
439843006978	DNA binding residues [nucleotide binding]
439843006979	dimerization interface [polypeptide binding]; other site
439843006980	Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088
439843006981	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
439843006982	thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412
439843006983	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
439843006984	catalytic residues [active]
439843006985	central insert; other site
439843006986	c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353
439843006987	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150
439843006988	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
439843006989	heme exporter protein CcmC; Region: ccmC; TIGR01191
439843006990	heme exporter protein CcmB; Region: ccmB; TIGR01190
439843006991	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
439843006992	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439843006993	Walker A/P-loop; other site
439843006994	ATP binding site [chemical binding]; other site
439843006995	Q-loop/lid; other site
439843006996	ABC transporter signature motif; other site
439843006997	Walker B; other site
439843006998	D-loop; other site
439843006999	H-loop/switch region; other site
439843007000	cytochrome c-type protein NapC; Provisional; Region: PRK10617
439843007001	Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005
439843007002	nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586
439843007003	quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477
439843007004	4Fe-4S binding domain; Region: Fer4_5; pfam12801
439843007005	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
439843007006	quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476
439843007007	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
439843007008	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
439843007009	[4Fe-4S] binding site [ion binding]; other site
439843007010	molybdopterin cofactor binding site; other site
439843007011	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
439843007012	molybdopterin cofactor binding site; other site
439843007013	assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553
439843007014	ferredoxin-type protein; Provisional; Region: PRK10194
439843007015	4Fe-4S binding domain; Region: Fer4; cl02805
439843007016	Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242
439843007017	secondary substrate binding site; other site
439843007018	primary substrate binding site; other site
439843007019	inhibition loop; other site
439843007020	dimerization interface [polypeptide binding]; other site
439843007021	multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522
439843007022	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
439843007023	Walker A/P-loop; other site
439843007024	ATP binding site [chemical binding]; other site
439843007025	Q-loop/lid; other site
439843007026	ABC transporter signature motif; other site
439843007027	Walker B; other site
439843007028	D-loop; other site
439843007029	H-loop/switch region; other site
439843007030	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
439843007031	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
439843007032	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
439843007033	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439843007034	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
439843007035	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
439843007036	DNA binding site [nucleotide binding]
439843007037	active site
439843007038	thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461
439843007039	ApbE family; Region: ApbE; pfam02424
439843007040	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
439843007041	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
439843007042	trimer interface [polypeptide binding]; other site
439843007043	eyelet of channel; other site
439843007044	phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618
439843007045	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439843007046	ATP binding site [chemical binding]; other site
439843007047	G-X-G motif; other site
439843007048	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
439843007049	putative binding surface; other site
439843007050	active site
439843007051	transcriptional regulator RcsB; Provisional; Region: PRK10840
439843007052	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843007053	active site
439843007054	phosphorylation site [posttranslational modification]
439843007055	intermolecular recognition site; other site
439843007056	dimerization interface [polypeptide binding]; other site
439843007057	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
439843007058	DNA binding residues [nucleotide binding]
439843007059	dimerization interface [polypeptide binding]; other site
439843007060	hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841
439843007061	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439843007062	dimer interface [polypeptide binding]; other site
439843007063	phosphorylation site [posttranslational modification]
439843007064	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439843007065	ATP binding site [chemical binding]; other site
439843007066	Mg2+ binding site [ion binding]; other site
439843007067	G-X-G motif; other site
439843007068	RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456
439843007069	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843007070	active site
439843007071	phosphorylation site [posttranslational modification]
439843007072	intermolecular recognition site; other site
439843007073	dimerization interface [polypeptide binding]; other site
439843007074	DNA gyrase subunit A; Validated; Region: PRK05560
439843007075	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
439843007076	CAP-like domain; other site
439843007077	active site
439843007078	primary dimer interface [polypeptide binding]; other site
439843007079	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
439843007080	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
439843007081	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
439843007082	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
439843007083	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
439843007084	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
439843007085	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
439843007086	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
439843007087	active site pocket [active]
439843007088	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
439843007089	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843007090	putative substrate translocation pore; other site
439843007091	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
439843007092	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439843007093	S-adenosylmethionine binding site [chemical binding]; other site
439843007094	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103
439843007095	ATP cone domain; Region: ATP-cone; pfam03477
439843007096	Class I ribonucleotide reductase; Region: RNR_I; cd01679
439843007097	active site
439843007098	dimer interface [polypeptide binding]; other site
439843007099	catalytic residues [active]
439843007100	effector binding site; other site
439843007101	R2 peptide binding site; other site
439843007102	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
439843007103	dimer interface [polypeptide binding]; other site
439843007104	putative radical transfer pathway; other site
439843007105	diiron center [ion binding]; other site
439843007106	tyrosyl radical; other site
439843007107	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
439843007108	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
439843007109	catalytic loop [active]
439843007110	iron binding site [ion binding]; other site
439843007111	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
439843007112	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843007113	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
439843007114	dimerization interface [polypeptide binding]; other site
439843007115	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
439843007116	Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600
439843007117	active site
439843007118	catalytic site [active]
439843007119	metal binding site [ion binding]; metal-binding site
439843007120	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
439843007121	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843007122	putative substrate translocation pore; other site
439843007123	sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101
439843007124	hydroxyglutarate oxidase; Provisional; Region: PRK11728
439843007125	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
439843007126	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075
439843007127	anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329
439843007128	glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379
439843007129	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
439843007130	Cysteine-rich domain; Region: CCG; pfam02754
439843007131	Cysteine-rich domain; Region: CCG; pfam02754
439843007132	deubiquitinase SseL; Provisional; Region: PRK14848
439843007133	Competence-damaged protein; Region: CinA; cl00666
439843007134	2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128
439843007135	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843007136	D-galactonate transporter; Region: 2A0114; TIGR00893
439843007137	putative substrate translocation pore; other site
439843007138	L-rhamnonate dehydratase; Provisional; Region: PRK15440
439843007139	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327
439843007140	putative active site pocket [active]
439843007141	putative metal binding site [ion binding]; other site
439843007142	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
439843007143	Transcriptional regulator [Transcription]; Region: IclR; COG1414
439843007144	Bacterial transcriptional regulator; Region: IclR; pfam01614
439843007145	hypothetical protein; Provisional; Region: PRK03673
439843007146	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
439843007147	putative MPT binding site; other site
439843007148	Competence-damaged protein; Region: CinA; cl00666
439843007149	YfaZ precursor; Region: YfaZ; pfam07437
439843007150	nucleoside triphosphatase NudI; Provisional; Region: PRK15472
439843007151	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
439843007152	catalytic core [active]
439843007153	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
439843007154	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
439843007155	inhibitor-cofactor binding pocket; inhibition site
439843007156	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843007157	catalytic residue [active]
439843007158	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
439843007159	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
439843007160	Ligand binding site; other site
439843007161	Putative Catalytic site; other site
439843007162	DXD motif; other site
439843007163	bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125
439843007164	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
439843007165	active site
439843007166	substrate binding site [chemical binding]; other site
439843007167	cosubstrate binding site; other site
439843007168	catalytic site [active]
439843007169	C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702
439843007170	active site
439843007171	hexamer interface [polypeptide binding]; other site
439843007172	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
439843007173	NAD binding site [chemical binding]; other site
439843007174	substrate binding site [chemical binding]; other site
439843007175	active site
439843007176	4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394
439843007177	Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939
439843007178	putative active site [active]
439843007179	putative catalytic site [active]
439843007180	putative Zn binding site [ion binding]; other site
439843007181	4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279
439843007182	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
439843007183	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051
439843007184	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
439843007185	signal transduction protein PmrD; Provisional; Region: PRK15450
439843007186	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029
439843007187	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
439843007188	acyl-activating enzyme (AAE) consensus motif; other site
439843007189	putative AMP binding site [chemical binding]; other site
439843007190	putative active site [active]
439843007191	putative CoA binding site [chemical binding]; other site
439843007192	O-succinylbenzoate synthase [Coenzyme metabolism]; Region: MenC; COG1441
439843007193	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
439843007194	active site
439843007195	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
439843007196	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
439843007197	substrate binding site [chemical binding]; other site
439843007198	oxyanion hole (OAH) forming residues; other site
439843007199	trimer interface [polypeptide binding]; other site
439843007200	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126
439843007201	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
439843007202	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
439843007203	dimer interface [polypeptide binding]; other site
439843007204	tetramer interface [polypeptide binding]; other site
439843007205	PYR/PP interface [polypeptide binding]; other site
439843007206	TPP binding site [chemical binding]; other site
439843007207	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
439843007208	TPP-binding site; other site
439843007209	menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012
439843007210	isochorismate synthases; Region: isochor_syn; TIGR00543
439843007211	hypothetical protein; Provisional; Region: PRK10404
439843007212	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
439843007213	Coenzyme A binding pocket [chemical binding]; other site
439843007214	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
439843007215	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
439843007216	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
439843007217	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843007218	active site
439843007219	phosphorylation site [posttranslational modification]
439843007220	intermolecular recognition site; other site
439843007221	dimerization interface [polypeptide binding]; other site
439843007222	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
439843007223	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
439843007224	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
439843007225	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
439843007226	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
439843007227	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
439843007228	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
439843007229	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
439843007230	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
439843007231	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
439843007232	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
439843007233	4Fe-4S binding domain; Region: Fer4; pfam00037
439843007234	4Fe-4S binding domain; Region: Fer4; pfam00037
439843007235	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
439843007236	NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034
439843007237	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
439843007238	catalytic loop [active]
439843007239	iron binding site [ion binding]; other site
439843007240	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
439843007241	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
439843007242	[4Fe-4S] binding site [ion binding]; other site
439843007243	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
439843007244	NADH dehydrogenase I subunit F; Provisional; Region: PRK11278
439843007245	SLBB domain; Region: SLBB; pfam10531
439843007246	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
439843007247	NADH dehydrogenase subunit E; Validated; Region: PRK07539
439843007248	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
439843007249	putative dimer interface [polypeptide binding]; other site
439843007250	[2Fe-2S] cluster binding site [ion binding]; other site
439843007251	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
439843007252	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
439843007253	NADH dehydrogenase subunit D; Validated; Region: PRK06075
439843007254	NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377
439843007255	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
439843007256	DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092
439843007257	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843007258	The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439
439843007259	putative dimerization interface [polypeptide binding]; other site
439843007260	aminotransferase AlaT; Validated; Region: PRK09265
439843007261	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
439843007262	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843007263	homodimer interface [polypeptide binding]; other site
439843007264	catalytic residue [active]
439843007265	5'-nucleotidase; Provisional; Region: PRK03826
439843007266	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
439843007267	transmembrane helices; other site
439843007268	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
439843007269	TrkA-C domain; Region: TrkA_C; pfam02080
439843007270	TrkA-C domain; Region: TrkA_C; pfam02080
439843007271	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
439843007272	putative phosphatase; Provisional; Region: PRK11587
439843007273	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439843007274	motif II; other site
439843007275	hypothetical protein; Validated; Region: PRK05445
439843007276	hypothetical protein; Provisional; Region: PRK01816
439843007277	propionate/acetate kinase; Provisional; Region: PRK12379
439843007278	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
439843007279	phosphate acetyltransferase; Reviewed; Region: PRK05632
439843007280	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
439843007281	DRTGG domain; Region: DRTGG; pfam07085
439843007282	phosphate acetyltransferase; Region: pta; TIGR00651
439843007283	hypothetical protein; Provisional; Region: PRK11588
439843007284	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
439843007285	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
439843007286	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
439843007287	PYR/PP interface [polypeptide binding]; other site
439843007288	dimer interface [polypeptide binding]; other site
439843007289	TPP binding site [chemical binding]; other site
439843007290	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
439843007291	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
439843007292	TPP-binding site [chemical binding]; other site
439843007293	dimer interface [polypeptide binding]; other site
439843007294	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK12996
439843007295	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
439843007296	active site
439843007297	P-loop; other site
439843007298	phosphorylation site [posttranslational modification]
439843007299	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
439843007300	active site
439843007301	phosphorylation site [posttranslational modification]
439843007302	Transcriptional regulators [Transcription]; Region: PurR; COG1609
439843007303	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
439843007304	DNA binding site [nucleotide binding]
439843007305	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
439843007306	putative dimerization interface [polypeptide binding]; other site
439843007307	putative ligand binding site [chemical binding]; other site
439843007308	NUDIX hydrolase YfcD; Provisional; Region: PRK15393
439843007309	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697
439843007310	nudix motif; other site
439843007311	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
439843007312	active site
439843007313	metal binding site [ion binding]; metal-binding site
439843007314	homotetramer interface [polypeptide binding]; other site
439843007315	glutathione S-transferase; Provisional; Region: PRK15113
439843007316	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
439843007317	C-terminal domain interface [polypeptide binding]; other site
439843007318	GSH binding site (G-site) [chemical binding]; other site
439843007319	dimer interface [polypeptide binding]; other site
439843007320	C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195
439843007321	N-terminal domain interface [polypeptide binding]; other site
439843007322	putative dimer interface [polypeptide binding]; other site
439843007323	putative substrate binding pocket (H-site) [chemical binding]; other site
439843007324	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
439843007325	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
439843007326	C-terminal domain interface [polypeptide binding]; other site
439843007327	GSH binding site (G-site) [chemical binding]; other site
439843007328	dimer interface [polypeptide binding]; other site
439843007329	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
439843007330	N-terminal domain interface [polypeptide binding]; other site
439843007331	putative dimer interface [polypeptide binding]; other site
439843007332	active site
439843007333	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
439843007334	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
439843007335	putative NAD(P) binding site [chemical binding]; other site
439843007336	putative active site [active]
439843007337	histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619
439843007338	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
439843007339	Walker A/P-loop; other site
439843007340	ATP binding site [chemical binding]; other site
439843007341	Q-loop/lid; other site
439843007342	ABC transporter signature motif; other site
439843007343	Walker B; other site
439843007344	D-loop; other site
439843007345	H-loop/switch region; other site
439843007346	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
439843007347	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843007348	dimer interface [polypeptide binding]; other site
439843007349	conserved gate region; other site
439843007350	putative PBP binding loops; other site
439843007351	ABC-ATPase subunit interface; other site
439843007352	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
439843007353	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843007354	dimer interface [polypeptide binding]; other site
439843007355	conserved gate region; other site
439843007356	putative PBP binding loops; other site
439843007357	ABC-ATPase subunit interface; other site
439843007358	histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437
439843007359	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
439843007360	substrate binding pocket [chemical binding]; other site
439843007361	membrane-bound complex binding site; other site
439843007362	hinge residues; other site
439843007363	ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010
439843007364	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
439843007365	substrate binding pocket [chemical binding]; other site
439843007366	membrane-bound complex binding site; other site
439843007367	hinge residues; other site
439843007368	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
439843007369	Flavoprotein; Region: Flavoprotein; pfam02441
439843007370	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
439843007371	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
439843007372	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815
439843007373	dimer interface [polypeptide binding]; other site
439843007374	active site
439843007375	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
439843007376	substrate binding site [chemical binding]; other site
439843007377	catalytic residue [active]
439843007378	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
439843007379	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
439843007380	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
439843007381	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
439843007382	catalytic residue [active]
439843007383	PAS fold; Region: PAS_4; pfam08448
439843007384	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
439843007385	putative active site [active]
439843007386	heme pocket [chemical binding]; other site
439843007387	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
439843007388	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439843007389	Walker A motif; other site
439843007390	ATP binding site [chemical binding]; other site
439843007391	Walker B motif; other site
439843007392	arginine finger; other site
439843007393	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
439843007394	amidophosphoribosyltransferase; Provisional; Region: PRK09246
439843007395	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
439843007396	active site
439843007397	tetramer interface [polypeptide binding]; other site
439843007398	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
439843007399	active site
439843007400	colicin V production protein; Provisional; Region: PRK10845
439843007401	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
439843007402	cell division protein DedD; Provisional; Region: PRK11633
439843007403	Sporulation related domain; Region: SPOR; pfam05036
439843007404	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
439843007405	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
439843007406	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
439843007407	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
439843007408	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
439843007409	hypothetical protein; Provisional; Region: PRK10847
439843007410	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
439843007411	Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101
439843007412	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
439843007413	dimerization interface 3.5A [polypeptide binding]; other site
439843007414	active site
439843007415	putative semialdehyde dehydrogenase; Provisional; Region: PRK08040
439843007416	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
439843007417	erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438
439843007418	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
439843007419	ligand binding site [chemical binding]; other site
439843007420	NAD binding site [chemical binding]; other site
439843007421	catalytic site [active]
439843007422	homodimer interface [polypeptide binding]; other site
439843007423	flagella biosynthesis regulator; Provisional; Region: flk; PRK10715
439843007424	putative transporter; Provisional; Region: PRK12382
439843007425	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843007426	putative substrate translocation pore; other site
439843007427	Protein of unknown function (DUF3828); Region: DUF3828; pfam12883
439843007428	CAAX protease self-immunity; Region: Abi; pfam02517
439843007429	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
439843007430	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
439843007431	dimer interface [polypeptide binding]; other site
439843007432	active site
439843007433	Uncharacterized conserved protein [Function unknown]; Region: COG4121
439843007434	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
439843007435	YfcL protein; Region: YfcL; pfam08891
439843007436	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101
439843007437	hypothetical protein; Provisional; Region: PRK10621
439843007438	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
439843007439	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
439843007440	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
439843007441	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
439843007442	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
439843007443	Tetramer interface [polypeptide binding]; other site
439843007444	active site
439843007445	FMN-binding site [chemical binding]; other site
439843007446	HemK family putative methylases; Region: hemK_fam; TIGR00536
439843007447	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439843007448	S-adenosylmethionine binding site [chemical binding]; other site
439843007449	hypothetical protein; Provisional; Region: PRK04946
439843007450	Smr domain; Region: Smr; pfam01713
439843007451	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
439843007452	catalytic core [active]
439843007453	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
439843007454	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
439843007455	substrate binding site [chemical binding]; other site
439843007456	oxyanion hole (OAH) forming residues; other site
439843007457	trimer interface [polypeptide binding]; other site
439843007458	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
439843007459	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
439843007460	3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963
439843007461	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
439843007462	dimer interface [polypeptide binding]; other site
439843007463	active site
439843007464	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691
439843007465	long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716
439843007466	ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091
439843007467	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
439843007468	outer membrane protease; Reviewed; Region: PRK10993
439843007469	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
439843007470	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843007471	active site
439843007472	phosphorylation site [posttranslational modification]
439843007473	intermolecular recognition site; other site
439843007474	dimerization interface [polypeptide binding]; other site
439843007475	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
439843007476	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
439843007477	Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192
439843007478	HAMP domain; Region: HAMP; pfam00672
439843007479	dimerization interface [polypeptide binding]; other site
439843007480	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439843007481	dimer interface [polypeptide binding]; other site
439843007482	phosphorylation site [posttranslational modification]
439843007483	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439843007484	ATP binding site [chemical binding]; other site
439843007485	Mg2+ binding site [ion binding]; other site
439843007486	G-X-G motif; other site
439843007487	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
439843007488	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
439843007489	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
439843007490	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843007491	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843007492	Protein of unknown function (DUF2545); Region: DUF2545; pfam10810
439843007493	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
439843007494	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
439843007495	putative acyl-acceptor binding pocket; other site
439843007496	aminotransferase; Validated; Region: PRK08175
439843007497	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
439843007498	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843007499	homodimer interface [polypeptide binding]; other site
439843007500	catalytic residue [active]
439843007501	glucokinase; Provisional; Region: glk; PRK00292
439843007502	glucokinase, proteobacterial type; Region: glk; TIGR00749
439843007503	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
439843007504	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
439843007505	Cl- selectivity filter; other site
439843007506	Cl- binding residues [ion binding]; other site
439843007507	pore gating glutamate residue; other site
439843007508	dimer interface [polypeptide binding]; other site
439843007509	indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393
439843007510	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
439843007511	dimer interface [polypeptide binding]; other site
439843007512	PYR/PP interface [polypeptide binding]; other site
439843007513	TPP binding site [chemical binding]; other site
439843007514	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
439843007515	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
439843007516	TPP-binding site [chemical binding]; other site
439843007517	dimer interface [polypeptide binding]; other site
439843007518	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
439843007519	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
439843007520	active site
439843007521	catalytic tetrad [active]
439843007522	Protein of unknown function (DUF2502); Region: DUF2502; pfam10697
439843007523	manganese transport protein MntH; Reviewed; Region: PRK00701
439843007524	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
439843007525	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
439843007526	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
439843007527	Nucleoside recognition; Region: Gate; pfam07670
439843007528	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
439843007529	MASE1; Region: MASE1; pfam05231
439843007530	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
439843007531	diguanylate cyclase; Region: GGDEF; smart00267
439843007532	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
439843007533	Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037
439843007534	Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037
439843007535	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
439843007536	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
439843007537	active site
439843007538	HIGH motif; other site
439843007539	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
439843007540	active site
439843007541	KMSKS motif; other site
439843007542	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
439843007543	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843007544	The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449
439843007545	putative dimerization interface [polypeptide binding]; other site
439843007546	putative substrate binding pocket [chemical binding]; other site
439843007547	XapX domain; Region: XapX; TIGR03510
439843007548	nucleoside transporter; Region: 2A0110; TIGR00889
439843007549	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843007550	putative substrate translocation pore; other site
439843007551	purine nucleoside phosphorylase; Provisional; Region: PRK08202
439843007552	hypothetical protein; Provisional; Region: PRK11528
439843007553	Transcriptional regulator [Transcription]; Region: LysR; COG0583
439843007554	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843007555	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
439843007556	putative dimerization interface [polypeptide binding]; other site
439843007557	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
439843007558	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
439843007559	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530
439843007560	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
439843007561	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
439843007562	nucleotide binding pocket [chemical binding]; other site
439843007563	K-X-D-G motif; other site
439843007564	catalytic site [active]
439843007565	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
439843007566	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
439843007567	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
439843007568	Dimer interface [polypeptide binding]; other site
439843007569	BRCT sequence motif; other site
439843007570	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038
439843007571	cell division protein ZipA; Provisional; Region: PRK03427
439843007572	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231
439843007573	FtsZ protein binding site [polypeptide binding]; other site
439843007574	putative sulfate transport protein CysZ; Validated; Region: PRK04949
439843007575	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
439843007576	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
439843007577	dimer interface [polypeptide binding]; other site
439843007578	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843007579	catalytic residue [active]
439843007580	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
439843007581	dimerization domain swap beta strand [polypeptide binding]; other site
439843007582	regulatory protein interface [polypeptide binding]; other site
439843007583	active site
439843007584	regulatory phosphorylation site [posttranslational modification]; other site
439843007585	phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177
439843007586	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
439843007587	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
439843007588	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
439843007589	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
439843007590	HPr interaction site; other site
439843007591	glycerol kinase (GK) interaction site [polypeptide binding]; other site
439843007592	active site
439843007593	phosphorylation site [posttranslational modification]
439843007594	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
439843007595	dimer interface [polypeptide binding]; other site
439843007596	pyridoxamine kinase; Validated; Region: PRK05756
439843007597	pyridoxal binding site [chemical binding]; other site
439843007598	ATP binding site [chemical binding]; other site
439843007599	transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481
439843007600	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439843007601	DNA-binding site [nucleotide binding]; DNA binding site
439843007602	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
439843007603	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843007604	homodimer interface [polypeptide binding]; other site
439843007605	catalytic residue [active]
439843007606	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
439843007607	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
439843007608	catalytic triad [active]
439843007609	hypothetical protein; Provisional; Region: PRK10318
439843007610	cysteine synthase B; Region: cysM; TIGR01138
439843007611	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
439843007612	dimer interface [polypeptide binding]; other site
439843007613	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843007614	catalytic residue [active]
439843007615	sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851
439843007616	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
439843007617	Walker A/P-loop; other site
439843007618	ATP binding site [chemical binding]; other site
439843007619	Q-loop/lid; other site
439843007620	ABC transporter signature motif; other site
439843007621	Walker B; other site
439843007622	D-loop; other site
439843007623	H-loop/switch region; other site
439843007624	TOBE-like domain; Region: TOBE_3; pfam12857
439843007625	sulfate transport protein; Provisional; Region: cysT; CHL00187
439843007626	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843007627	dimer interface [polypeptide binding]; other site
439843007628	conserved gate region; other site
439843007629	putative PBP binding loops; other site
439843007630	ABC-ATPase subunit interface; other site
439843007631	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
439843007632	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843007633	dimer interface [polypeptide binding]; other site
439843007634	conserved gate region; other site
439843007635	putative PBP binding loops; other site
439843007636	ABC-ATPase subunit interface; other site
439843007637	thiosulfate transporter subunit; Provisional; Region: PRK10852
439843007638	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
439843007639	short chain dehydrogenase; Provisional; Region: PRK08226
439843007640	human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368
439843007641	NAD binding site [chemical binding]; other site
439843007642	homotetramer interface [polypeptide binding]; other site
439843007643	homodimer interface [polypeptide binding]; other site
439843007644	active site
439843007645	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
439843007646	RpoE-regulated lipoprotein; Provisional; Region: PRK10718
439843007647	Protein of unknown function (DUF1131); Region: DUF1131; pfam06572
439843007648	Protein of unknown function (DUF2919); Region: DUF2919; pfam11143
439843007649	putative acetyltransferase; Provisional; Region: PRK03624
439843007650	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
439843007651	Coenzyme A binding pocket [chemical binding]; other site
439843007652	N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319
439843007653	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
439843007654	active site
439843007655	metal binding site [ion binding]; metal-binding site
439843007656	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
439843007657	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
439843007658	transcriptional regulator EutR; Provisional; Region: PRK10130
439843007659	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439843007660	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439843007661	carboxysome structural protein EutK; Provisional; Region: PRK15466
439843007662	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
439843007663	Hexamer interface [polypeptide binding]; other site
439843007664	Hexagonal pore residue; other site
439843007665	ethanolamine utilization protein EutL; Provisional; Region: PRK15405
439843007666	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049
439843007667	putative hexamer interface [polypeptide binding]; other site
439843007668	putative hexagonal pore; other site
439843007669	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050
439843007670	putative hexamer interface [polypeptide binding]; other site
439843007671	putative hexagonal pore; other site
439843007672	Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302
439843007673	Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303
439843007674	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
439843007675	reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719
439843007676	Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192
439843007677	ethanol dehydrogenase EutG; Provisional; Region: PRK15454
439843007678	iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551
439843007679	active site
439843007680	metal binding site [ion binding]; metal-binding site
439843007681	Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820
439843007682	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
439843007683	nucleotide binding site [chemical binding]; other site
439843007684	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
439843007685	putative catalytic cysteine [active]
439843007686	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
439843007687	Hexamer/Pentamer interface [polypeptide binding]; other site
439843007688	central pore; other site
439843007689	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
439843007690	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
439843007691	Hexamer interface [polypeptide binding]; other site
439843007692	Putative hexagonal pore residue; other site
439843007693	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
439843007694	ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020
439843007695	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
439843007696	Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766
439843007697	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
439843007698	G1 box; other site
439843007699	GTP/Mg2+ binding site [chemical binding]; other site
439843007700	G2 box; other site
439843007701	Switch I region; other site
439843007702	G3 box; other site
439843007703	Switch II region; other site
439843007704	G4 box; other site
439843007705	G5 box; other site
439843007706	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
439843007707	putative hexamer interface [polypeptide binding]; other site
439843007708	putative hexagonal pore; other site
439843007709	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
439843007710	Malic enzyme, N-terminal domain; Region: malic; pfam00390
439843007711	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
439843007712	putative NAD(P) binding site [chemical binding]; other site
439843007713	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
439843007714	transaldolase-like protein; Provisional; Region: PTZ00411
439843007715	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
439843007716	active site
439843007717	dimer interface [polypeptide binding]; other site
439843007718	catalytic residue [active]
439843007719	transketolase; Reviewed; Region: PRK12753
439843007720	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
439843007721	TPP-binding site [chemical binding]; other site
439843007722	dimer interface [polypeptide binding]; other site
439843007723	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
439843007724	PYR/PP interface [polypeptide binding]; other site
439843007725	dimer interface [polypeptide binding]; other site
439843007726	TPP binding site [chemical binding]; other site
439843007727	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
439843007728	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
439843007729	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
439843007730	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
439843007731	dimer interface [polypeptide binding]; other site
439843007732	ADP-ribose binding site [chemical binding]; other site
439843007733	active site
439843007734	nudix motif; other site
439843007735	metal binding site [ion binding]; metal-binding site
439843007736	putative periplasmic esterase; Provisional; Region: PRK03642
439843007737	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
439843007738	putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769
439843007739	4Fe-4S binding domain; Region: Fer4; pfam00037
439843007740	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
439843007741	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
439843007742	nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935
439843007743	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
439843007744	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
439843007745	dimerization interface [polypeptide binding]; other site
439843007746	Histidine kinase; Region: HisKA_3; pfam07730
439843007747	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439843007748	ATP binding site [chemical binding]; other site
439843007749	Mg2+ binding site [ion binding]; other site
439843007750	G-X-G motif; other site
439843007751	aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555
439843007752	Protein export membrane protein; Region: SecD_SecF; cl14618
439843007753	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
439843007754	ArsC family; Region: ArsC; pfam03960
439843007755	putative catalytic residues [active]
439843007756	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
439843007757	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
439843007758	metal binding site [ion binding]; metal-binding site
439843007759	dimer interface [polypeptide binding]; other site
439843007760	hypothetical protein; Provisional; Region: PRK13664
439843007761	Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444
439843007762	Helicase; Region: Helicase_RecD; pfam05127
439843007763	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
439843007764	Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725
439843007765	Predicted metalloprotease [General function prediction only]; Region: COG2321
439843007766	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
439843007767	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
439843007768	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
439843007769	ATP binding site [chemical binding]; other site
439843007770	active site
439843007771	substrate binding site [chemical binding]; other site
439843007772	lipoprotein; Provisional; Region: PRK11679
439843007773	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
439843007774	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
439843007775	dihydrodipicolinate synthase; Region: dapA; TIGR00674
439843007776	dimer interface [polypeptide binding]; other site
439843007777	active site
439843007778	catalytic residue [active]
439843007779	glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589
439843007780	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893
439843007781	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
439843007782	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
439843007783	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
439843007784	catalytic triad [active]
439843007785	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
439843007786	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
439843007787	fructuronate transporter; Provisional; Region: PRK10034; cl15264
439843007788	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
439843007789	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
439843007790	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
439843007791	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
439843007792	Domain of unknown function DUF20; Region: UPF0118; pfam01594
439843007793	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
439843007794	Peptidase family M48; Region: Peptidase_M48; cl12018
439843007795	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
439843007796	ArsC family; Region: ArsC; pfam03960
439843007797	catalytic residues [active]
439843007798	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
439843007799	DNA replication initiation factor; Provisional; Region: PRK08084
439843007800	uracil transporter; Provisional; Region: PRK10720
439843007801	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
439843007802	active site
439843007803	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
439843007804	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
439843007805	dimerization interface [polypeptide binding]; other site
439843007806	putative ATP binding site [chemical binding]; other site
439843007807	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
439843007808	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
439843007809	active site
439843007810	substrate binding site [chemical binding]; other site
439843007811	cosubstrate binding site; other site
439843007812	catalytic site [active]
439843007813	Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855
439843007814	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
439843007815	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
439843007816	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
439843007817	putative active site [active]
439843007818	catalytic site [active]
439843007819	Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167
439843007820	domain interface [polypeptide binding]; other site
439843007821	active site
439843007822	catalytic site [active]
439843007823	exopolyphosphatase; Provisional; Region: PRK10854
439843007824	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
439843007825	nucleotide binding site [chemical binding]; other site
439843007826	MASE1; Region: MASE1; pfam05231
439843007827	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
439843007828	diguanylate cyclase; Region: GGDEF; smart00267
439843007829	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
439843007830	Protein of unknown function (DUF2633); Region: DUF2633; pfam11119
439843007831	Integrase core domain; Region: rve; pfam00665
439843007832	GMP synthase; Reviewed; Region: guaA; PRK00074
439843007833	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
439843007834	AMP/PPi binding site [chemical binding]; other site
439843007835	candidate oxyanion hole; other site
439843007836	catalytic triad [active]
439843007837	potential glutamine specificity residues [chemical binding]; other site
439843007838	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
439843007839	ATP Binding subdomain [chemical binding]; other site
439843007840	Ligand Binding sites [chemical binding]; other site
439843007841	Dimerization subdomain; other site
439843007842	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
439843007843	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
439843007844	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
439843007845	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
439843007846	active site
439843007847	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
439843007848	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
439843007849	generic binding surface II; other site
439843007850	generic binding surface I; other site
439843007851	outer membrane protein RatA; Provisional; Region: PRK15315
439843007852	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
439843007853	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
439843007854	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
439843007855	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
439843007856	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
439843007857	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
439843007858	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
439843007859	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
439843007860	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
439843007861	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
439843007862	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
439843007863	intimin-like protein SinH; Provisional; Region: PRK15318
439843007864	intimin-like protein SinH; Provisional; Region: PRK15318
439843007865	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
439843007866	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
439843007867	Protein of unknown function (DUF1407); Region: DUF1407; pfam07191
439843007868	GTP-binding protein Der; Reviewed; Region: PRK00093
439843007869	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
439843007870	G1 box; other site
439843007871	GTP/Mg2+ binding site [chemical binding]; other site
439843007872	Switch I region; other site
439843007873	G2 box; other site
439843007874	Switch II region; other site
439843007875	G3 box; other site
439843007876	G4 box; other site
439843007877	G5 box; other site
439843007878	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
439843007879	G1 box; other site
439843007880	GTP/Mg2+ binding site [chemical binding]; other site
439843007881	Switch I region; other site
439843007882	G2 box; other site
439843007883	G3 box; other site
439843007884	Switch II region; other site
439843007885	G4 box; other site
439843007886	G5 box; other site
439843007887	outer membrane biogenesis protein BamB; Provisional; Region: PRK11138
439843007888	Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276
439843007889	Trp docking motif [polypeptide binding]; other site
439843007890	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
439843007891	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
439843007892	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
439843007893	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
439843007894	dimer interface [polypeptide binding]; other site
439843007895	motif 1; other site
439843007896	active site
439843007897	motif 2; other site
439843007898	motif 3; other site
439843007899	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
439843007900	anticodon binding site; other site
439843007901	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
439843007902	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
439843007903	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
439843007904	cytoskeletal protein RodZ; Provisional; Region: PRK10856
439843007905	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
439843007906	non-specific DNA binding site [nucleotide binding]; other site
439843007907	salt bridge; other site
439843007908	sequence-specific DNA binding site [nucleotide binding]; other site
439843007909	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
439843007910	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
439843007911	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439843007912	FeS/SAM binding site; other site
439843007913	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
439843007914	active site
439843007915	multimer interface [polypeptide binding]; other site
439843007916	4Fe-4S binding domain; Region: Fer4; pfam00037
439843007917	hydrogenase 4 subunit H; Validated; Region: PRK08222
439843007918	DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302
439843007919	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
439843007920	4Fe-4S binding domain; Region: Fer4; pfam00037
439843007921	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
439843007922	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
439843007923	putative [Fe4-S4] binding site [ion binding]; other site
439843007924	putative molybdopterin cofactor binding site [chemical binding]; other site
439843007925	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
439843007926	putative molybdopterin cofactor binding site; other site
439843007927	penicillin-binding protein 1C; Provisional; Region: PRK11240
439843007928	Transglycosylase; Region: Transgly; pfam00912
439843007929	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
439843007930	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
439843007931	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
439843007932	MG2 domain; Region: A2M_N; pfam01835
439843007933	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
439843007934	surface patch; other site
439843007935	thioester region; other site
439843007936	specificity defining residues; other site
439843007937	3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493
439843007938	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
439843007939	active site residue [active]
439843007940	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
439843007941	active site residue [active]
439843007942	enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611
439843007943	aminopeptidase B; Provisional; Region: PRK05015
439843007944	Peptidase; Region: DUF3663; pfam12404
439843007945	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
439843007946	interface (dimer of trimers) [polypeptide binding]; other site
439843007947	Substrate-binding/catalytic site; other site
439843007948	Zn-binding sites [ion binding]; other site
439843007949	hypothetical protein; Provisional; Region: PRK10721
439843007950	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
439843007951	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
439843007952	catalytic loop [active]
439843007953	iron binding site [ion binding]; other site
439843007954	chaperone protein HscA; Provisional; Region: hscA; PRK05183
439843007955	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
439843007956	nucleotide binding site [chemical binding]; other site
439843007957	putative NEF/HSP70 interaction site [polypeptide binding]; other site
439843007958	SBD interface [polypeptide binding]; other site
439843007959	co-chaperone HscB; Provisional; Region: hscB; PRK05014
439843007960	DnaJ domain; Region: DnaJ; pfam00226
439843007961	HSP70 interaction site [polypeptide binding]; other site
439843007962	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
439843007963	iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502
439843007964	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
439843007965	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
439843007966	trimerization site [polypeptide binding]; other site
439843007967	active site
439843007968	cysteine desulfurase; Provisional; Region: PRK14012
439843007969	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
439843007970	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
439843007971	catalytic residue [active]
439843007972	DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857
439843007973	Rrf2 family protein; Region: rrf2_super; TIGR00738
439843007974	tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114
439843007975	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
439843007976	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
439843007977	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
439843007978	active site
439843007979	dimerization interface [polypeptide binding]; other site
439843007980	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
439843007981	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
439843007982	sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910
439843007983	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
439843007984	anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221
439843007985	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
439843007986	FAD binding pocket [chemical binding]; other site
439843007987	FAD binding motif [chemical binding]; other site
439843007988	phosphate binding motif [ion binding]; other site
439843007989	beta-alpha-beta structure motif; other site
439843007990	NAD binding pocket [chemical binding]; other site
439843007991	Iron coordination center [ion binding]; other site
439843007992	sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912
439843007993	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
439843007994	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
439843007995	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215
439843007996	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683
439843007997	stationary phase inducible protein CsiE; Provisional; Region: PRK11564
439843007998	PRD domain; Region: PRD; pfam00874
439843007999	PRD domain; Region: PRD; pfam00874
439843008000	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
439843008001	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843008002	putative substrate translocation pore; other site
439843008003	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
439843008004	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
439843008005	dimer interface [polypeptide binding]; other site
439843008006	active site
439843008007	glycine-pyridoxal phosphate binding site [chemical binding]; other site
439843008008	folate binding site [chemical binding]; other site
439843008009	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
439843008010	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
439843008011	heme-binding site [chemical binding]; other site
439843008012	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
439843008013	FAD binding pocket [chemical binding]; other site
439843008014	FAD binding motif [chemical binding]; other site
439843008015	phosphate binding motif [ion binding]; other site
439843008016	beta-alpha-beta structure motif; other site
439843008017	NAD binding pocket [chemical binding]; other site
439843008018	Heme binding  pocket [chemical binding]; other site
439843008019	DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153
439843008020	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
439843008021	DNA binding site [nucleotide binding]
439843008022	lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435
439843008023	lysine decarboxylase CadA; Provisional; Region: PRK15400
439843008024	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
439843008025	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
439843008026	homodimer interface [polypeptide binding]; other site
439843008027	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843008028	catalytic residue [active]
439843008029	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
439843008030	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
439843008031	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843008032	putative substrate translocation pore; other site
439843008033	POT family; Region: PTR2; pfam00854
439843008034	nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858
439843008035	Nitrogen regulatory protein P-II; Region: P-II; smart00938
439843008036	response regulator GlrR; Provisional; Region: PRK15115
439843008037	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843008038	active site
439843008039	phosphorylation site [posttranslational modification]
439843008040	intermolecular recognition site; other site
439843008041	dimerization interface [polypeptide binding]; other site
439843008042	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439843008043	Walker A motif; other site
439843008044	ATP binding site [chemical binding]; other site
439843008045	Walker B motif; other site
439843008046	arginine finger; other site
439843008047	hypothetical protein; Provisional; Region: PRK10722
439843008048	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
439843008049	HAMP domain; Region: HAMP; pfam00672
439843008050	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439843008051	dimer interface [polypeptide binding]; other site
439843008052	phosphorylation site [posttranslational modification]
439843008053	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439843008054	ATP binding site [chemical binding]; other site
439843008055	Mg2+ binding site [ion binding]; other site
439843008056	G-X-G motif; other site
439843008057	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
439843008058	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
439843008059	dimerization interface [polypeptide binding]; other site
439843008060	ATP binding site [chemical binding]; other site
439843008061	Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of...; Region: PurL; cd02193
439843008062	dimerization interface [polypeptide binding]; other site
439843008063	ATP binding site [chemical binding]; other site
439843008064	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
439843008065	putative active site [active]
439843008066	catalytic triad [active]
439843008067	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
439843008068	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
439843008069	substrate binding pocket [chemical binding]; other site
439843008070	membrane-bound complex binding site; other site
439843008071	hinge residues; other site
439843008072	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
439843008073	N-acetyl-D-glucosamine binding site [chemical binding]; other site
439843008074	catalytic residue [active]
439843008075	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
439843008076	nucleoside/Zn binding site; other site
439843008077	dimer interface [polypeptide binding]; other site
439843008078	catalytic motif [active]
439843008079	hypothetical protein; Provisional; Region: PRK11590
439843008080	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
439843008081	PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586
439843008082	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
439843008083	active site turn [active]
439843008084	phosphorylation site [posttranslational modification]
439843008085	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
439843008086	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
439843008087	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
439843008088	putative active site [active]
439843008089	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
439843008090	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557
439843008091	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
439843008092	putative active site [active]
439843008093	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
439843008094	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
439843008095	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
439843008096	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
439843008097	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843008098	putative substrate translocation pore; other site
439843008099	Transcriptional regulator [Transcription]; Region: LysR; COG0583
439843008100	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843008101	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
439843008102	dimerization interface [polypeptide binding]; other site
439843008103	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
439843008104	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
439843008105	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
439843008106	active site
439843008107	hydrophilic channel; other site
439843008108	dimerization interface [polypeptide binding]; other site
439843008109	catalytic residues [active]
439843008110	active site lid [active]
439843008111	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
439843008112	Recombination protein O N terminal; Region: RecO_N; pfam11967
439843008113	Recombination protein O C terminal; Region: RecO_C; pfam02565
439843008114	GTPase Era; Reviewed; Region: era; PRK00089
439843008115	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
439843008116	G1 box; other site
439843008117	GTP/Mg2+ binding site [chemical binding]; other site
439843008118	Switch I region; other site
439843008119	G2 box; other site
439843008120	Switch II region; other site
439843008121	G3 box; other site
439843008122	G4 box; other site
439843008123	G5 box; other site
439843008124	KH domain; Region: KH_2; pfam07650
439843008125	ribonuclease III; Reviewed; Region: rnc; PRK00102
439843008126	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
439843008127	dimerization interface [polypeptide binding]; other site
439843008128	active site
439843008129	metal binding site [ion binding]; metal-binding site
439843008130	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
439843008131	dsRNA binding site [nucleotide binding]; other site
439843008132	rncO
439843008133	signal peptidase I; Provisional; Region: PRK10861
439843008134	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
439843008135	Catalytic site [active]
439843008136	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
439843008137	GTP-binding protein LepA; Provisional; Region: PRK05433
439843008138	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
439843008139	G1 box; other site
439843008140	putative GEF interaction site [polypeptide binding]; other site
439843008141	GTP/Mg2+ binding site [chemical binding]; other site
439843008142	Switch I region; other site
439843008143	G2 box; other site
439843008144	G3 box; other site
439843008145	Switch II region; other site
439843008146	G4 box; other site
439843008147	G5 box; other site
439843008148	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
439843008149	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
439843008150	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
439843008151	SoxR reducing system protein RseC; Provisional; Region: PRK10862
439843008152	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
439843008153	anti-sigma E factor; Provisional; Region: rseB; PRK09455
439843008154	anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863
439843008155	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
439843008156	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
439843008157	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
439843008158	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
439843008159	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
439843008160	DNA binding residues [nucleotide binding]
439843008161	L-aspartate oxidase; Provisional; Region: PRK09077
439843008162	L-aspartate oxidase; Provisional; Region: PRK06175
439843008163	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
439843008164	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
439843008165	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439843008166	S-adenosylmethionine binding site [chemical binding]; other site
439843008167	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
439843008168	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
439843008169	ATP binding site [chemical binding]; other site
439843008170	Mg++ binding site [ion binding]; other site
439843008171	motif III; other site
439843008172	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
439843008173	nucleotide binding region [chemical binding]; other site
439843008174	ATP-binding site [chemical binding]; other site
439843008175	Transcriptional regulator [Transcription]; Region: LysR; COG0583
439843008176	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843008177	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
439843008178	dimerization interface [polypeptide binding]; other site
439843008179	cysteine/O-acetylserine exporter; Provisional; Region: PRK10323
439843008180	autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127
439843008181	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
439843008182	ligand binding site [chemical binding]; other site
439843008183	active site
439843008184	UGI interface [polypeptide binding]; other site
439843008185	catalytic site [active]
439843008186	putative methyltransferase; Provisional; Region: PRK10864
439843008187	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
439843008188	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
439843008189	thioredoxin 2; Provisional; Region: PRK10996
439843008190	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
439843008191	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
439843008192	catalytic residues [active]
439843008193	Uncharacterized conserved protein [Function unknown]; Region: COG3148
439843008194	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
439843008195	CoA binding domain; Region: CoA_binding_2; pfam13380
439843008196	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
439843008197	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
439843008198	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
439843008199	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
439843008200	Coenzyme A binding pocket [chemical binding]; other site
439843008201	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
439843008202	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
439843008203	domain interface [polypeptide binding]; other site
439843008204	putative active site [active]
439843008205	catalytic site [active]
439843008206	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
439843008207	domain interface [polypeptide binding]; other site
439843008208	putative active site [active]
439843008209	catalytic site [active]
439843008210	lipoprotein; Provisional; Region: PRK10759
439843008211	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
439843008212	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843008213	putative substrate translocation pore; other site
439843008214	Domain of unknown function (DUF4385); Region: DUF4385; pfam14328
439843008215	protein disaggregation chaperone; Provisional; Region: PRK10865
439843008216	Clp amino terminal domain; Region: Clp_N; pfam02861
439843008217	Clp amino terminal domain; Region: Clp_N; pfam02861
439843008218	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439843008219	Walker A motif; other site
439843008220	ATP binding site [chemical binding]; other site
439843008221	Walker B motif; other site
439843008222	arginine finger; other site
439843008223	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439843008224	Walker A motif; other site
439843008225	ATP binding site [chemical binding]; other site
439843008226	Walker B motif; other site
439843008227	arginine finger; other site
439843008228	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
439843008229	hypothetical protein; Provisional; Region: PRK10723
439843008230	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
439843008231	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
439843008232	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
439843008233	RNA binding surface [nucleotide binding]; other site
439843008234	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
439843008235	active site
439843008236	outer membrane biogenesis protein BamD; Provisional; Region: PRK10866
439843008237	Protein of unknown function (DUF3897); Region: DUF3897; cl17494
439843008238	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
439843008239	30S subunit binding site; other site
439843008240	bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622
439843008241	chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797
439843008242	Prephenate dehydratase; Region: PDT; pfam00800
439843008243	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
439843008244	putative L-Phe binding site [chemical binding]; other site
439843008245	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
439843008246	bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199
439843008247	Chorismate mutase type II; Region: CM_2; cl00693
439843008248	prephenate dehydrogenase; Validated; Region: PRK08507
439843008249	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
439843008250	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
439843008251	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
439843008252	putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966
439843008253	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
439843008254	metal binding site [ion binding]; metal-binding site
439843008255	active site
439843008256	I-site; other site
439843008257	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
439843008258	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
439843008259	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
439843008260	RimM N-terminal domain; Region: RimM; pfam01782
439843008261	PRC-barrel domain; Region: PRC; pfam05239
439843008262	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
439843008263	signal recognition particle protein; Provisional; Region: PRK10867
439843008264	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
439843008265	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
439843008266	P loop; other site
439843008267	GTP binding site [chemical binding]; other site
439843008268	Signal peptide binding domain; Region: SRP_SPB; pfam02978
439843008269	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137
439843008270	hypothetical protein; Provisional; Region: PRK11573
439843008271	Domain of unknown function DUF21; Region: DUF21; pfam01595
439843008272	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
439843008273	Transporter associated domain; Region: CorC_HlyC; smart01091
439843008274	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
439843008275	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
439843008276	dimer interface [polypeptide binding]; other site
439843008277	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
439843008278	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378
439843008279	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
439843008280	recombination and repair protein; Provisional; Region: PRK10869
439843008281	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
439843008282	Walker A/P-loop; other site
439843008283	ATP binding site [chemical binding]; other site
439843008284	Q-loop/lid; other site
439843008285	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
439843008286	ABC transporter signature motif; other site
439843008287	Walker B; other site
439843008288	D-loop; other site
439843008289	H-loop/switch region; other site
439843008290	outer membrane biogenesis protein BamE; Provisional; Region: PRK11548
439843008291	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
439843008292	hypothetical protein; Validated; Region: PRK01777
439843008293	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
439843008294	putative coenzyme Q binding site [chemical binding]; other site
439843008295	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
439843008296	SmpB-tmRNA interface; other site
439843008297	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439843008298	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439843008299	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439843008300	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439843008301	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439843008302	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439843008303	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439843008304	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439843008305	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439843008306	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439843008307	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439843008308	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439843008309	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439843008310	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
439843008311	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439843008312	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439843008313	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
439843008314	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
439843008315	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
439843008316	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
439843008317	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439843008318	Walker A/P-loop; other site
439843008319	ATP binding site [chemical binding]; other site
439843008320	Q-loop/lid; other site
439843008321	ABC transporter signature motif; other site
439843008322	Walker B; other site
439843008323	D-loop; other site
439843008324	H-loop/switch region; other site
439843008325	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
439843008326	HlyD family secretion protein; Region: HlyD_3; pfam13437
439843008327	integrase; Provisional; Region: PRK09692
439843008328	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
439843008329	active site
439843008330	Int/Topo IB signature motif; other site
439843008331	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
439843008332	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
439843008333	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
439843008334	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
439843008335	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
439843008336	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
439843008337	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
439843008338	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
439843008339	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
439843008340	putative active site [active]
439843008341	putative NTP binding site [chemical binding]; other site
439843008342	putative nucleic acid binding site [nucleotide binding]; other site
439843008343	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
439843008344	putative active site [active]
439843008345	putative NTP binding site [chemical binding]; other site
439843008346	putative nucleic acid binding site [nucleotide binding]; other site
439843008347	Repressor of phase-1 flagellin; Region: Flag1_repress; pfam03614
439843008348	flagellin; Validated; Region: PRK08026
439843008349	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
439843008350	Flagellin D3 domain; Region: Flagellin_D3; pfam08884
439843008351	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
439843008352	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
439843008353	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
439843008354	catalytic residues [active]
439843008355	catalytic nucleophile [active]
439843008356	Presynaptic Site I dimer interface [polypeptide binding]; other site
439843008357	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
439843008358	Synaptic Flat tetramer interface [polypeptide binding]; other site
439843008359	Synaptic Site I dimer interface [polypeptide binding]; other site
439843008360	DNA binding site [nucleotide binding]
439843008361	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
439843008362	DNA-binding interface [nucleotide binding]; DNA binding site
439843008363	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
439843008364	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
439843008365	homodimer interface [polypeptide binding]; other site
439843008366	active site
439843008367	TDP-binding site; other site
439843008368	acceptor substrate-binding pocket; other site
439843008369	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
439843008370	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439843008371	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
439843008372	Walker A/P-loop; other site
439843008373	ATP binding site [chemical binding]; other site
439843008374	Q-loop/lid; other site
439843008375	ABC transporter signature motif; other site
439843008376	Walker B; other site
439843008377	D-loop; other site
439843008378	H-loop/switch region; other site
439843008379	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
439843008380	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
439843008381	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439843008382	Walker A/P-loop; other site
439843008383	ATP binding site [chemical binding]; other site
439843008384	Q-loop/lid; other site
439843008385	ABC transporter signature motif; other site
439843008386	Walker B; other site
439843008387	D-loop; other site
439843008388	H-loop/switch region; other site
439843008389	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
439843008390	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
439843008391	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
439843008392	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
439843008393	outer membrane receptor FepA; Provisional; Region: PRK13528
439843008394	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
439843008395	N-terminal plug; other site
439843008396	ligand-binding site [chemical binding]; other site
439843008397	secreted effector protein PipB2; Provisional; Region: PRK15196
439843008398	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
439843008399	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
439843008400	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
439843008401	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
439843008402	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
439843008403	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990
439843008404	antimicrobial resistance protein Mig-14; Provisional; Region: PRK15312
439843008405	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
439843008406	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
439843008407	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
439843008408	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
439843008409	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
439843008410	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439843008411	dimer interface [polypeptide binding]; other site
439843008412	phosphorylation site [posttranslational modification]
439843008413	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439843008414	ATP binding site [chemical binding]; other site
439843008415	Mg2+ binding site [ion binding]; other site
439843008416	G-X-G motif; other site
439843008417	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
439843008418	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843008419	active site
439843008420	phosphorylation site [posttranslational modification]
439843008421	intermolecular recognition site; other site
439843008422	dimerization interface [polypeptide binding]; other site
439843008423	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
439843008424	DNA binding site [nucleotide binding]
439843008425	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
439843008426	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
439843008427	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
439843008428	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250
439843008429	substrate binding pocket [chemical binding]; other site
439843008430	active site
439843008431	iron coordination sites [ion binding]; other site
439843008432	Predicted dehydrogenase [General function prediction only]; Region: COG0579
439843008433	hydroxyglutarate oxidase; Provisional; Region: PRK11728
439843008434	4-aminobutyrate aminotransferase; Validated; Region: PRK08088
439843008435	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
439843008436	inhibitor-cofactor binding pocket; inhibition site
439843008437	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843008438	catalytic residue [active]
439843008439	gamma-aminobutyrate transporter; Provisional; Region: PRK10197
439843008440	DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534
439843008441	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439843008442	DNA-binding site [nucleotide binding]; DNA binding site
439843008443	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
439843008444	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
439843008445	bacterial OsmY and nodulation domain; Region: BON; smart00749
439843008446	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
439843008447	Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401
439843008448	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
439843008449	dimerization interface [polypeptide binding]; other site
439843008450	putative DNA binding site [nucleotide binding]; other site
439843008451	Transcriptional regulators [Transcription]; Region: MarR; COG1846
439843008452	putative Zn2+ binding site [ion binding]; other site
439843008453	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
439843008454	active site residue [active]
439843008455	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
439843008456	DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328
439843008457	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
439843008458	Protein of unknown function (DUF1144); Region: DUF1144; pfam06610
439843008459	hypothetical protein; Provisional; Region: PRK10556
439843008460	hypothetical protein; Provisional; Region: PRK10132
439843008461	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
439843008462	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439843008463	DNA-binding site [nucleotide binding]; DNA binding site
439843008464	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
439843008465	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843008466	homodimer interface [polypeptide binding]; other site
439843008467	catalytic residue [active]
439843008468	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
439843008469	Uncharacterized conserved protein [Function unknown]; Region: COG2128
439843008470	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
439843008471	catalytic residues [active]
439843008472	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
439843008473	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
439843008474	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
439843008475	Class I ribonucleotide reductase; Region: RNR_I; cd01679
439843008476	active site
439843008477	dimer interface [polypeptide binding]; other site
439843008478	catalytic residues [active]
439843008479	effector binding site; other site
439843008480	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
439843008481	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
439843008482	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
439843008483	dimer interface [polypeptide binding]; other site
439843008484	putative radical transfer pathway; other site
439843008485	diiron center [ion binding]; other site
439843008486	tyrosyl radical; other site
439843008487	glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070
439843008488	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
439843008489	Walker A/P-loop; other site
439843008490	ATP binding site [chemical binding]; other site
439843008491	Q-loop/lid; other site
439843008492	ABC transporter signature motif; other site
439843008493	Walker B; other site
439843008494	D-loop; other site
439843008495	H-loop/switch region; other site
439843008496	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
439843008497	glycine betaine transporter membrane protein; Provisional; Region: PRK10952
439843008498	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843008499	dimer interface [polypeptide binding]; other site
439843008500	conserved gate region; other site
439843008501	putative PBP binding loops; other site
439843008502	ABC-ATPase subunit interface; other site
439843008503	glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119
439843008504	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
439843008505	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
439843008506	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843008507	transcriptional repressor MprA; Provisional; Region: PRK10870
439843008508	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
439843008509	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
439843008510	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
439843008511	HlyD family secretion protein; Region: HlyD_3; pfam13437
439843008512	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
439843008513	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843008514	putative substrate translocation pore; other site
439843008515	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843008516	Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471
439843008517	S-ribosylhomocysteinase; Provisional; Region: PRK02260
439843008518	glutamate--cysteine ligase; Provisional; Region: PRK02107
439843008519	Predicted membrane protein [Function unknown]; Region: COG1238
439843008520	fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725
439843008521	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439843008522	motif II; other site
439843008523	carbon storage regulator; Provisional; Region: PRK01712
439843008524	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
439843008525	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
439843008526	motif 1; other site
439843008527	active site
439843008528	motif 2; other site
439843008529	motif 3; other site
439843008530	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
439843008531	DHHA1 domain; Region: DHHA1; pfam02272
439843008532	recombination regulator RecX; Reviewed; Region: recX; PRK00117
439843008533	recombinase A; Provisional; Region: recA; PRK09354
439843008534	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
439843008535	hexamer interface [polypeptide binding]; other site
439843008536	Walker A motif; other site
439843008537	ATP binding site [chemical binding]; other site
439843008538	Walker B motif; other site
439843008539	hypothetical protein; Validated; Region: PRK03661
439843008540	Transglycosylase SLT domain; Region: SLT_2; pfam13406
439843008541	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
439843008542	N-acetyl-D-glucosamine binding site [chemical binding]; other site
439843008543	PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821
439843008544	Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732
439843008545	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
439843008546	Nucleoside recognition; Region: Gate; pfam07670
439843008547	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
439843008548	PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377
439843008549	sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384
439843008550	Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322
439843008551	putative NAD(P) binding site [chemical binding]; other site
439843008552	active site
439843008553	DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234
439843008554	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
439843008555	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
439843008556	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
439843008557	D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543
439843008558	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
439843008559	putative active site [active]
439843008560	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
439843008561	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
439843008562	GAF domain; Region: GAF; pfam01590
439843008563	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439843008564	Walker A motif; other site
439843008565	ATP binding site [chemical binding]; other site
439843008566	Walker B motif; other site
439843008567	arginine finger; other site
439843008568	anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452
439843008569	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
439843008570	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
439843008571	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
439843008572	iron binding site [ion binding]; other site
439843008573	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
439843008574	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
439843008575	Acylphosphatase; Region: Acylphosphatase; pfam00708
439843008576	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
439843008577	HypF finger; Region: zf-HYPF; pfam07503
439843008578	HypF finger; Region: zf-HYPF; pfam07503
439843008579	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
439843008580	formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330
439843008581	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
439843008582	Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067
439843008583	nickel binding site [ion binding]; other site
439843008584	formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084
439843008585	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
439843008586	formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387
439843008587	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
439843008588	Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262
439843008589	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
439843008590	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
439843008591	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
439843008592	NADH dehydrogenase; Region: NADHdh; cl00469
439843008593	formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042
439843008594	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
439843008595	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
439843008596	formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198
439843008597	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
439843008598	hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681
439843008599	hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463
439843008600	hydrogenase assembly chaperone; Provisional; Region: PRK10409
439843008601	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
439843008602	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
439843008603	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
439843008604	dimerization interface [polypeptide binding]; other site
439843008605	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
439843008606	ATP binding site [chemical binding]; other site
439843008607	formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429
439843008608	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
439843008609	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
439843008610	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439843008611	Walker A motif; other site
439843008612	ATP binding site [chemical binding]; other site
439843008613	Walker B motif; other site
439843008614	arginine finger; other site
439843008615	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
439843008616	Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756
439843008617	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
439843008618	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
439843008619	metal binding site [ion binding]; metal-binding site
439843008620	manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056
439843008621	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
439843008622	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
439843008623	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
439843008624	ABC-ATPase subunit  interface; other site
439843008625	dimer interface [polypeptide binding]; other site
439843008626	putative PBP binding regions; other site
439843008627	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
439843008628	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
439843008629	ABC-ATPase subunit  interface; other site
439843008630	dimer interface [polypeptide binding]; other site
439843008631	putative PBP binding regions; other site
439843008632	effector protein YopJ; Provisional; Region: PRK15371
439843008633	transcriptional activator SprB; Provisional; Region: PRK15320
439843008634	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
439843008635	transcriptional regulator SirC; Provisional; Region: PRK15044
439843008636	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439843008637	putative type III secretion system effector protein OrgC; Provisional; Region: PRK15321
439843008638	invasion protein OrgB; Provisional; Region: PRK15322
439843008639	type III secretion apparatus protein OrgA/MxiK; Region: OrgA_MxiK; TIGR02555
439843008640	invasion protein OrgA; Provisional; Region: PRK15323
439843008641	type III secretion system lipoprotein PrgK; Provisional; Region: PRK15324
439843008642	type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325
439843008643	type III secretion system needle complex protein PrgI; Provisional; Region: PRK15326
439843008644	type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327
439843008645	Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480
439843008646	transcriptional regulator HilD; Provisional; Region: PRK15185
439843008647	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439843008648	invasion protein regulator; Provisional; Region: PRK12370
439843008649	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
439843008650	DNA binding site [nucleotide binding]
439843008651	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
439843008652	binding surface
439843008653	TPR motif; other site
439843008654	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
439843008655	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
439843008656	N-acetyl-D-glucosamine binding site [chemical binding]; other site
439843008657	catalytic residue [active]
439843008658	pathogenicity island 1 effector protein StpP; Provisional; Region: PRK15375
439843008659	SicP binding; Region: SicP-binding; pfam09119
439843008660	GTPase-activating protein (GAP) domain found in bacterial cytotoxins, ExoS, SptP, and YopE. Part of protein secretion system; stimulates Rac1- dependent cytoskeletal changes that promote bacterial internalization; Region: ToxGAP; cd00219
439843008661	switch II binding region; other site
439843008662	Rac1 P-loop interaction site [polypeptide binding]; other site
439843008663	GTP binding residues [chemical binding]; other site
439843008664	switch I binding region; other site
439843008665	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047
439843008666	active site
439843008667	chaperone protein SicP; Provisional; Region: PRK15329
439843008668	putative acyl carrier protein IacP; Validated; Region: PRK08172
439843008669	pathogenicity island 1 effector protein SipA; Provisional; Region: PRK15376
439843008670	cell invasion protein SipD; Provisional; Region: PRK15330
439843008671	pathogenicity island 1 effector protein SipC; Provisional; Region: PRK15373
439843008672	pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374
439843008673	chaperone protein SicA; Provisional; Region: PRK15331
439843008674	Tetratricopeptide repeat; Region: TPR_3; pfam07720
439843008675	Tetratricopeptide repeat; Region: TPR_3; pfam07720
439843008676	type III secretion system protein SpaS; Validated; Region: PRK08156
439843008677	type III secretion system protein SpaR; Provisional; Region: PRK15332
439843008678	type III secretion system protein SpaQ; Provisional; Region: PRK15333
439843008679	type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796
439843008680	type III secretion system protein SpaO; Validated; Region: PRK08158
439843008681	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
439843008682	antigen presentation protein SpaN; Provisional; Region: PRK15334
439843008683	Surface presentation of antigens protein; Region: SPAN; pfam02510
439843008684	Salmonella surface presentation of antigen gene type M protein; Region: SPAM; pfam02090
439843008685	ATP synthase SpaL; Validated; Region: PRK08149
439843008686	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
439843008687	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
439843008688	Walker A motif; other site
439843008689	ATP binding site [chemical binding]; other site
439843008690	Walker B motif; other site
439843008691	type III secretion system chaperone SpaK; Provisional; Region: PRK15336
439843008692	Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789
439843008693	type III secretion system protein InvA; Provisional; Region: PRK15337
439843008694	type III secretion system regulator InvE; Provisional; Region: PRK15338
439843008695	type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568
439843008696	type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339
439843008697	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
439843008698	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
439843008699	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
439843008700	transcriptional regulator InvF; Provisional; Region: PRK15340
439843008701	InvH outer membrane lipoprotein; Region: InvH; pfam04741
439843008702	PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424
439843008703	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
439843008704	active site
439843008705	metal binding site [ion binding]; metal-binding site
439843008706	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
439843008707	MutS domain I; Region: MutS_I; pfam01624
439843008708	MutS domain II; Region: MutS_II; pfam05188
439843008709	MutS domain III; Region: MutS_III; pfam05192
439843008710	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
439843008711	Walker A/P-loop; other site
439843008712	ATP binding site [chemical binding]; other site
439843008713	Q-loop/lid; other site
439843008714	ABC transporter signature motif; other site
439843008715	Walker B; other site
439843008716	D-loop; other site
439843008717	H-loop/switch region; other site
439843008718	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460
439843008719	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843008720	Major Facilitator Superfamily; Region: MFS_1; pfam07690
439843008721	putative substrate translocation pore; other site
439843008722	Transcriptional regulator [Transcription]; Region: LysR; COG0583
439843008723	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843008724	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
439843008725	putative effector binding pocket; other site
439843008726	dimerization interface [polypeptide binding]; other site
439843008727	GntP family permease; Region: GntP_permease; pfam02447
439843008728	fructuronate transporter; Provisional; Region: PRK10034; cl15264
439843008729	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
439843008730	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
439843008731	putative NAD(P) binding site [chemical binding]; other site
439843008732	active site
439843008733	putative substrate binding site [chemical binding]; other site
439843008734	hypothetical protein; Provisional; Region: PRK09989
439843008735	putative aldolase; Validated; Region: PRK08130
439843008736	intersubunit interface [polypeptide binding]; other site
439843008737	active site
439843008738	Zn2+ binding site [ion binding]; other site
439843008739	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
439843008740	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
439843008741	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
439843008742	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
439843008743	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
439843008744	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
439843008745	MarR family; Region: MarR_2; cl17246
439843008746	Transcriptional regulators [Transcription]; Region: MarR; COG1846
439843008747	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
439843008748	Flavoprotein; Region: Flavoprotein; pfam02441
439843008749	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
439843008750	RNA polymerase sigma factor RpoS; Validated; Region: PRK05657
439843008751	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
439843008752	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
439843008753	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
439843008754	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
439843008755	DNA binding residues [nucleotide binding]
439843008756	lipoprotein NlpD; Provisional; Region: nlpD; PRK10871
439843008757	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
439843008758	Peptidase family M23; Region: Peptidase_M23; pfam01551
439843008759	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
439843008760	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439843008761	S-adenosylmethionine binding site [chemical binding]; other site
439843008762	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
439843008763	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
439843008764	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
439843008765	Permutation of conserved domain; other site
439843008766	active site
439843008767	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
439843008768	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
439843008769	homotrimer interaction site [polypeptide binding]; other site
439843008770	zinc binding site [ion binding]; other site
439843008771	CDP-binding sites; other site
439843008772	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
439843008773	substrate binding site; other site
439843008774	dimer interface; other site
439843008775	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
439843008776	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
439843008777	Protein of unknown function (DUF3561); Region: DUF3561; pfam12084
439843008778	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
439843008779	ligand-binding site [chemical binding]; other site
439843008780	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
439843008781	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
439843008782	CysD dimerization site [polypeptide binding]; other site
439843008783	G1 box; other site
439843008784	putative GEF interaction site [polypeptide binding]; other site
439843008785	GTP/Mg2+ binding site [chemical binding]; other site
439843008786	Switch I region; other site
439843008787	G2 box; other site
439843008788	G3 box; other site
439843008789	Switch II region; other site
439843008790	G4 box; other site
439843008791	G5 box; other site
439843008792	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
439843008793	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
439843008794	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
439843008795	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
439843008796	Active Sites [active]
439843008797	alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199
439843008798	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
439843008799	metal binding site [ion binding]; metal-binding site
439843008800	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648
439843008801	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719
439843008802	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09664
439843008803	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
439843008804	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645
439843008805	CT1975-like protein; Region: Cas_CT1975; pfam09344
439843008806	CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09670
439843008807	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669
439843008808	helicase Cas3; Provisional; Region: PRK09694
439843008809	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
439843008810	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
439843008811	pathogenicity island 1 effector protein SopD; Provisional; Region: PRK15379
439843008812	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
439843008813	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
439843008814	Active Sites [active]
439843008815	sulfite reductase subunit beta; Provisional; Region: PRK13504
439843008816	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
439843008817	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
439843008818	sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953
439843008819	Flavodoxin; Region: Flavodoxin_1; pfam00258
439843008820	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
439843008821	FAD binding pocket [chemical binding]; other site
439843008822	FAD binding motif [chemical binding]; other site
439843008823	catalytic residues [active]
439843008824	NAD binding pocket [chemical binding]; other site
439843008825	phosphate binding motif [ion binding]; other site
439843008826	beta-alpha-beta structure motif; other site
439843008827	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
439843008828	active site
439843008829	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
439843008830	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
439843008831	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
439843008832	enolase; Provisional; Region: eno; PRK00077
439843008833	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
439843008834	dimer interface [polypeptide binding]; other site
439843008835	metal binding site [ion binding]; metal-binding site
439843008836	substrate binding pocket [chemical binding]; other site
439843008837	CTP synthetase; Validated; Region: pyrG; PRK05380
439843008838	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
439843008839	Catalytic site [active]
439843008840	active site
439843008841	UTP binding site [chemical binding]; other site
439843008842	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
439843008843	active site
439843008844	putative oxyanion hole; other site
439843008845	catalytic triad [active]
439843008846	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
439843008847	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
439843008848	homodimer interface [polypeptide binding]; other site
439843008849	metal binding site [ion binding]; metal-binding site
439843008850	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
439843008851	homodimer interface [polypeptide binding]; other site
439843008852	active site
439843008853	putative chemical substrate binding site [chemical binding]; other site
439843008854	metal binding site [ion binding]; metal-binding site
439843008855	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
439843008856	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
439843008857	(p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872
439843008858	HD domain; Region: HD_4; pfam13328
439843008859	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
439843008860	synthetase active site [active]
439843008861	NTP binding site [chemical binding]; other site
439843008862	metal binding site [ion binding]; metal-binding site
439843008863	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
439843008864	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
439843008865	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
439843008866	TRAM domain; Region: TRAM; pfam01938
439843008867	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439843008868	S-adenosylmethionine binding site [chemical binding]; other site
439843008869	hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107
439843008870	Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984
439843008871	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
439843008872	dimerization interface [polypeptide binding]; other site
439843008873	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439843008874	dimer interface [polypeptide binding]; other site
439843008875	phosphorylation site [posttranslational modification]
439843008876	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439843008877	ATP binding site [chemical binding]; other site
439843008878	Mg2+ binding site [ion binding]; other site
439843008879	G-X-G motif; other site
439843008880	Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999
439843008881	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843008882	active site
439843008883	phosphorylation site [posttranslational modification]
439843008884	intermolecular recognition site; other site
439843008885	dimerization interface [polypeptide binding]; other site
439843008886	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
439843008887	putative binding surface; other site
439843008888	active site
439843008889	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
439843008890	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
439843008891	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
439843008892	active site
439843008893	tetramer interface [polypeptide binding]; other site
439843008894	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
439843008895	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
439843008896	active site
439843008897	tetramer interface [polypeptide binding]; other site
439843008898	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843008899	D-galactonate transporter; Region: 2A0114; TIGR00893
439843008900	putative substrate translocation pore; other site
439843008901	flavodoxin; Provisional; Region: PRK08105
439843008902	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
439843008903	tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563
439843008904	probable active site [active]
439843008905	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098
439843008906	SecY interacting protein Syd; Provisional; Region: PRK04968
439843008907	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
439843008908	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
439843008909	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
439843008910	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
439843008911	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
439843008912	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
439843008913	serine transporter; Region: stp; TIGR00814
439843008914	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
439843008915	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
439843008916	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
439843008917	flap endonuclease-like protein; Provisional; Region: PRK09482
439843008918	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
439843008919	active site
439843008920	metal binding site 1 [ion binding]; metal-binding site
439843008921	putative 5' ssDNA interaction site; other site
439843008922	metal binding site 3; metal-binding site
439843008923	metal binding site 2 [ion binding]; metal-binding site
439843008924	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
439843008925	putative DNA binding site [nucleotide binding]; other site
439843008926	putative metal binding site [ion binding]; other site
439843008927	L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624
439843008928	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
439843008929	dimer interface [polypeptide binding]; other site
439843008930	active site
439843008931	metal binding site [ion binding]; metal-binding site
439843008932	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
439843008933	intersubunit interface [polypeptide binding]; other site
439843008934	active site
439843008935	Zn2+ binding site [ion binding]; other site
439843008936	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
439843008937	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843008938	putative substrate translocation pore; other site
439843008939	L-fucose isomerase; Provisional; Region: fucI; PRK10991
439843008940	L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556
439843008941	hexamer (dimer of trimers) interface [polypeptide binding]; other site
439843008942	trimer interface [polypeptide binding]; other site
439843008943	substrate binding site [chemical binding]; other site
439843008944	Mn binding site [ion binding]; other site
439843008945	L-fuculokinase; Provisional; Region: PRK10331
439843008946	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
439843008947	nucleotide binding site [chemical binding]; other site
439843008948	L-fucose mutarotase; Provisional; Region: fucU; PRK15420
439843008949	DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411
439843008950	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
439843008951	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
439843008952	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
439843008953	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
439843008954	hypothetical protein; Provisional; Region: PRK10873
439843008955	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
439843008956	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843008957	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
439843008958	dimerization interface [polypeptide binding]; other site
439843008959	substrate binding pocket [chemical binding]; other site
439843008960	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
439843008961	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
439843008962	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
439843008963	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
439843008964	catalytic residue [active]
439843008965	CsdA-binding activator; Provisional; Region: PRK15019
439843008966	Predicted permeases [General function prediction only]; Region: RarD; COG2962
439843008967	sulfur acceptor protein CsdL; Provisional; Region: PRK15116
439843008968	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
439843008969	putative ATP binding site [chemical binding]; other site
439843008970	putative substrate interface [chemical binding]; other site
439843008971	murein transglycosylase A; Provisional; Region: mltA; PRK11162
439843008972	murein hydrolase B; Provisional; Region: PRK10760; cl17906
439843008973	MltA specific insert domain; Region: MltA; pfam03562
439843008974	3D domain; Region: 3D; pfam06725
439843008975	AMIN domain; Region: AMIN; pfam11741
439843008976	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
439843008977	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
439843008978	active site
439843008979	metal binding site [ion binding]; metal-binding site
439843008980	N-acetylglutamate synthase; Validated; Region: PRK05279
439843008981	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
439843008982	putative feedback inhibition sensing region; other site
439843008983	putative nucleotide binding site [chemical binding]; other site
439843008984	putative substrate binding site [chemical binding]; other site
439843008985	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
439843008986	Coenzyme A binding pocket [chemical binding]; other site
439843008987	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
439843008988	AAA domain; Region: AAA_30; pfam13604
439843008989	Family description; Region: UvrD_C_2; pfam13538
439843008990	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
439843008991	protease3; Provisional; Region: PRK15101
439843008992	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
439843008993	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
439843008994	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
439843008995	Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330
439843008996	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
439843008997	hypothetical protein; Provisional; Region: PRK10332
439843008998	Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528
439843008999	hypothetical protein; Provisional; Region: PRK11521
439843009000	hypothetical protein; Provisional; Region: PRK10557
439843009001	hypothetical protein; Provisional; Region: PRK10506
439843009002	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
439843009003	thymidylate synthase; Reviewed; Region: thyA; PRK01827
439843009004	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
439843009005	dimerization interface [polypeptide binding]; other site
439843009006	active site
439843009007	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
439843009008	fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061
439843009009	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
439843009010	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
439843009011	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
439843009012	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
439843009013	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
439843009014	putative active site [active]
439843009015	Ap4A binding site [chemical binding]; other site
439843009016	nudix motif; other site
439843009017	putative metal binding site [ion binding]; other site
439843009018	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
439843009019	putative DNA-binding cleft [nucleotide binding]; other site
439843009020	putative DNA clevage site; other site
439843009021	molecular lever; other site
439843009022	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
439843009023	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
439843009024	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
439843009025	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
439843009026	active site
439843009027	catalytic tetrad [active]
439843009028	lysophospholipid transporter LplT; Provisional; Region: PRK11195
439843009029	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843009030	bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043
439843009031	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
439843009032	putative acyl-acceptor binding pocket; other site
439843009033	C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909
439843009034	acyl-activating enzyme (AAE) consensus motif; other site
439843009035	putative AMP binding site [chemical binding]; other site
439843009036	DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727
439843009037	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
439843009038	DNA binding site [nucleotide binding]
439843009039	domain linker motif; other site
439843009040	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
439843009041	dimerization interface (closed form) [polypeptide binding]; other site
439843009042	ligand binding site [chemical binding]; other site
439843009043	Transcriptional regulators [Transcription]; Region: PurR; COG1609
439843009044	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
439843009045	DNA binding site [nucleotide binding]
439843009046	domain linker motif; other site
439843009047	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
439843009048	dimerization interface (closed form) [polypeptide binding]; other site
439843009049	ligand binding site [chemical binding]; other site
439843009050	diaminopimelate decarboxylase; Provisional; Region: PRK11165
439843009051	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
439843009052	active site
439843009053	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
439843009054	substrate binding site [chemical binding]; other site
439843009055	catalytic residues [active]
439843009056	dimer interface [polypeptide binding]; other site
439843009057	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
439843009058	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843009059	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
439843009060	dimerization interface [polypeptide binding]; other site
439843009061	putative racemase; Provisional; Region: PRK10200
439843009062	aspartate racemase; Region: asp_race; TIGR00035
439843009063	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
439843009064	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843009065	putative substrate translocation pore; other site
439843009066	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843009067	2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993
439843009068	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
439843009069	NADP binding site [chemical binding]; other site
439843009070	homodimer interface [polypeptide binding]; other site
439843009071	active site
439843009072	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
439843009073	putative acyltransferase; Provisional; Region: PRK05790
439843009074	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
439843009075	dimer interface [polypeptide binding]; other site
439843009076	active site
439843009077	Transcriptional regulator [Transcription]; Region: LysR; COG0583
439843009078	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843009079	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
439843009080	dimerization interface [polypeptide binding]; other site
439843009081	Predicted membrane protein [Function unknown]; Region: COG4125
439843009082	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
439843009083	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
439843009084	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
439843009085	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
439843009086	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
439843009087	putative metal binding site [ion binding]; other site
439843009088	putative homodimer interface [polypeptide binding]; other site
439843009089	putative homotetramer interface [polypeptide binding]; other site
439843009090	putative homodimer-homodimer interface [polypeptide binding]; other site
439843009091	putative allosteric switch controlling residues; other site
439843009092	nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019
439843009093	transcriptional activator SprB; Provisional; Region: PRK15320
439843009094	Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14600
439843009095	Protein of unknown function (DUF1401); Region: DUF1401; pfam07180
439843009096	Fimbrial protein; Region: Fimbrial; pfam00419
439843009097	fimbrial chaperone protein StdC; Provisional; Region: PRK15254
439843009098	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
439843009099	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
439843009100	fimbrial outer membrane usher protein StdB; Provisional; Region: PRK15255
439843009101	PapC N-terminal domain; Region: PapC_N; pfam13954
439843009102	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
439843009103	PapC C-terminal domain; Region: PapC_C; pfam13953
439843009104	fimbrial protein StdA; Provisional; Region: PRK15210
439843009105	hypothetical protein; Provisional; Region: PRK10316
439843009106	YfdX protein; Region: YfdX; pfam10938
439843009107	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
439843009108	Protein of unknown function (DUF1460); Region: DUF1460; pfam07313
439843009109	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
439843009110	Peptidase family M23; Region: Peptidase_M23; pfam01551
439843009111	Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443
439843009112	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
439843009113	active site
439843009114	metal binding site [ion binding]; metal-binding site
439843009115	nudix motif; other site
439843009116	lysyl-tRNA synthetase; Reviewed; Region: PRK12445
439843009117	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
439843009118	dimer interface [polypeptide binding]; other site
439843009119	putative anticodon binding site; other site
439843009120	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
439843009121	motif 1; other site
439843009122	active site
439843009123	motif 2; other site
439843009124	motif 3; other site
439843009125	This domain is found in peptide chain release factors; Region: PCRF; smart00937
439843009126	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
439843009127	RF-1 domain; Region: RF-1; pfam00472
439843009128	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
439843009129	DHH family; Region: DHH; pfam01368
439843009130	DHHA1 domain; Region: DHHA1; pfam02272
439843009131	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
439843009132	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
439843009133	dimerization domain [polypeptide binding]; other site
439843009134	dimer interface [polypeptide binding]; other site
439843009135	catalytic residues [active]
439843009136	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
439843009137	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
439843009138	active site
439843009139	Int/Topo IB signature motif; other site
439843009140	flavodoxin FldB; Provisional; Region: PRK12359
439843009141	Protein of unknown function (DUF1434); Region: DUF1434; pfam07254
439843009142	hypothetical protein; Provisional; Region: PRK10878
439843009143	putative global regulator; Reviewed; Region: PRK09559
439843009144	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
439843009145	hemolysin; Provisional; Region: PRK15087
439843009146	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
439843009147	ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552
439843009148	6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014
439843009149	beta-galactosidase; Region: BGL; TIGR03356
439843009150	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
439843009151	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
439843009152	lipoyl attachment site [posttranslational modification]; other site
439843009153	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
439843009154	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
439843009155	oxidoreductase; Provisional; Region: PRK08013
439843009156	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
439843009157	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732
439843009158	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
439843009159	proline aminopeptidase P II; Provisional; Region: PRK10879
439843009160	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
439843009161	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
439843009162	active site
439843009163	hypothetical protein; Reviewed; Region: PRK01736
439843009164	Z-ring-associated protein; Provisional; Region: PRK10972
439843009165	5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333
439843009166	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
439843009167	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
439843009168	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
439843009169	ligand binding site [chemical binding]; other site
439843009170	NAD binding site [chemical binding]; other site
439843009171	tetramer interface [polypeptide binding]; other site
439843009172	catalytic site [active]
439843009173	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
439843009174	L-serine binding site [chemical binding]; other site
439843009175	ACT domain interface; other site
439843009176	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
439843009177	tetramer (dimer of dimers) interface [polypeptide binding]; other site
439843009178	active site
439843009179	dimer interface [polypeptide binding]; other site
439843009180	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
439843009181	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843009182	The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428
439843009183	putative dimerization interface [polypeptide binding]; other site
439843009184	Uncharacterized conserved protein [Function unknown]; Region: COG2968
439843009185	oxidative stress defense protein; Provisional; Region: PRK11087
439843009186	arginine exporter protein; Provisional; Region: PRK09304
439843009187	mechanosensitive channel MscS; Provisional; Region: PRK10334
439843009188	Mechanosensitive ion channel; Region: MS_channel; pfam00924
439843009189	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
439843009190	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
439843009191	active site
439843009192	intersubunit interface [polypeptide binding]; other site
439843009193	zinc binding site [ion binding]; other site
439843009194	Na+ binding site [ion binding]; other site
439843009195	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
439843009196	Phosphoglycerate kinase; Region: PGK; pfam00162
439843009197	substrate binding site [chemical binding]; other site
439843009198	hinge regions; other site
439843009199	ADP binding site [chemical binding]; other site
439843009200	catalytic site [active]
439843009201	erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535
439843009202	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
439843009203	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
439843009204	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
439843009205	trimer interface [polypeptide binding]; other site
439843009206	putative Zn binding site [ion binding]; other site
439843009207	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
439843009208	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
439843009209	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
439843009210	Walker A/P-loop; other site
439843009211	ATP binding site [chemical binding]; other site
439843009212	Q-loop/lid; other site
439843009213	ABC transporter signature motif; other site
439843009214	Walker B; other site
439843009215	D-loop; other site
439843009216	H-loop/switch region; other site
439843009217	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
439843009218	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
439843009219	Walker A/P-loop; other site
439843009220	ATP binding site [chemical binding]; other site
439843009221	Q-loop/lid; other site
439843009222	ABC transporter signature motif; other site
439843009223	Walker B; other site
439843009224	D-loop; other site
439843009225	H-loop/switch region; other site
439843009226	nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270
439843009227	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
439843009228	active site
439843009229	Transcriptional regulator [Transcription]; Region: MtlR; COG3722
439843009230	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022
439843009231	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
439843009232	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
439843009233	putative active site [active]
439843009234	L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238
439843009235	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
439843009236	putative NAD(P) binding site [chemical binding]; other site
439843009237	catalytic Zn binding site [ion binding]; other site
439843009238	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
439843009239	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
439843009240	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
439843009241	active site
439843009242	P-loop; other site
439843009243	phosphorylation site [posttranslational modification]
439843009244	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
439843009245	active site
439843009246	phosphorylation site [posttranslational modification]
439843009247	transketolase; Reviewed; Region: PRK12753
439843009248	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
439843009249	TPP-binding site [chemical binding]; other site
439843009250	dimer interface [polypeptide binding]; other site
439843009251	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
439843009252	PYR/PP interface [polypeptide binding]; other site
439843009253	dimer interface [polypeptide binding]; other site
439843009254	TPP binding site [chemical binding]; other site
439843009255	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
439843009256	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
439843009257	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
439843009258	agmatinase; Region: agmatinase; TIGR01230
439843009259	oligomer interface [polypeptide binding]; other site
439843009260	putative active site [active]
439843009261	Mn binding site [ion binding]; other site
439843009262	Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166
439843009263	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
439843009264	dimer interface [polypeptide binding]; other site
439843009265	active site
439843009266	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
439843009267	catalytic residues [active]
439843009268	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
439843009269	Virulence promoting factor; Region: YqgB; pfam11036
439843009270	S-adenosylmethionine synthetase; Validated; Region: PRK05250
439843009271	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
439843009272	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
439843009273	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
439843009274	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
439843009275	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843009276	putative substrate translocation pore; other site
439843009277	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843009278	hypothetical protein; Provisional; Region: PRK04860
439843009279	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
439843009280	DNA-specific endonuclease I; Provisional; Region: PRK15137
439843009281	Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356
439843009282	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
439843009283	RNA methyltransferase, RsmE family; Region: TIGR00046
439843009284	glutathione synthetase; Provisional; Region: PRK05246
439843009285	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
439843009286	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
439843009287	hypothetical protein; Validated; Region: PRK00228
439843009288	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
439843009289	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
439843009290	Transcriptional regulator [Transcription]; Region: IclR; COG1414
439843009291	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
439843009292	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
439843009293	Walker A motif; other site
439843009294	ATP binding site [chemical binding]; other site
439843009295	Walker B motif; other site
439843009296	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
439843009297	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
439843009298	catalytic residue [active]
439843009299	YGGT family; Region: YGGT; pfam02325
439843009300	YGGT family; Region: YGGT; pfam02325
439843009301	hypothetical protein; Validated; Region: PRK05090
439843009302	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
439843009303	active site
439843009304	dimerization interface [polypeptide binding]; other site
439843009305	HemN family oxidoreductase; Provisional; Region: PRK05660
439843009306	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439843009307	FeS/SAM binding site; other site
439843009308	HemN C-terminal domain; Region: HemN_C; pfam06969
439843009309	Protein of unknown function (DUF1202); Region: DUF1202; pfam06717
439843009310	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411
439843009311	homodimer interface [polypeptide binding]; other site
439843009312	active site
439843009313	hypothetical protein; Provisional; Region: PRK10626
439843009314	Protein of unknown function (DUF2884); Region: DUF2884; pfam11101
439843009315	hypothetical protein; Provisional; Region: PRK11702
439843009316	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
439843009317	adenine DNA glycosylase; Provisional; Region: PRK10880
439843009318	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
439843009319	minor groove reading motif; other site
439843009320	helix-hairpin-helix signature motif; other site
439843009321	substrate binding pocket [chemical binding]; other site
439843009322	active site
439843009323	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
439843009324	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
439843009325	DNA binding and oxoG recognition site [nucleotide binding]
439843009326	oxidative damage protection protein; Provisional; Region: PRK05408
439843009327	murein transglycosylase C; Provisional; Region: mltC; PRK11671
439843009328	Domain of unknown function (DUF3393); Region: DUF3393; pfam11873
439843009329	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
439843009330	N-acetyl-D-glucosamine binding site [chemical binding]; other site
439843009331	catalytic residue [active]
439843009332	nucleoside transporter; Region: 2A0110; TIGR00889
439843009333	ornithine decarboxylase; Provisional; Region: PRK13578
439843009334	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
439843009335	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
439843009336	homodimer interface [polypeptide binding]; other site
439843009337	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843009338	catalytic residue [active]
439843009339	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
439843009340	Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811
439843009341	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
439843009342	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
439843009343	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
439843009344	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
439843009345	putative active site [active]
439843009346	putative catalytic site [active]
439843009347	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
439843009348	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
439843009349	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843009350	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
439843009351	putative dimerization interface [polypeptide binding]; other site
439843009352	putative substrate binding pocket [chemical binding]; other site
439843009353	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
439843009354	Sulfatase; Region: Sulfatase; pfam00884
439843009355	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
439843009356	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439843009357	FeS/SAM binding site; other site
439843009358	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
439843009359	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
439843009360	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
439843009361	DNA binding residues [nucleotide binding]
439843009362	dimerization interface [polypeptide binding]; other site
439843009363	Protein of unknown function (DUF3156); Region: DUF3156; pfam11354
439843009364	Amino acid permease; Region: AA_permease_2; pfam13520
439843009365	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
439843009366	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
439843009367	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
439843009368	Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113
439843009369	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
439843009370	NAD(P) binding site [chemical binding]; other site
439843009371	catalytic residues [active]
439843009372	DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128
439843009373	Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion,    and vesicular transport]; Region: Hcp; COG3157
439843009374	Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938
439843009375	active site
439843009376	catalytic site [active]
439843009377	Zn binding site [ion binding]; other site
439843009378	tetramer interface [polypeptide binding]; other site
439843009379	Predicted amidohydrolase [General function prediction only]; Region: COG0388
439843009380	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
439843009381	putative active site [active]
439843009382	catalytic triad [active]
439843009383	putative dimer interface [polypeptide binding]; other site
439843009384	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
439843009385	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
439843009386	beta-D-glucuronidase; Provisional; Region: PRK10150
439843009387	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
439843009388	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
439843009389	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
439843009390	glucuronide transporter; Provisional; Region: PRK09848
439843009391	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843009392	putative substrate translocation pore; other site
439843009393	putative outer membrane porin protein; Provisional; Region: PRK11379
439843009394	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843009395	D-galactonate transporter; Region: 2A0114; TIGR00893
439843009396	putative substrate translocation pore; other site
439843009397	mannonate dehydratase; Provisional; Region: PRK03906
439843009398	mannonate dehydratase; Region: uxuA; TIGR00695
439843009399	D-mannonate oxidoreductase; Provisional; Region: PRK15037
439843009400	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
439843009401	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
439843009402	Glucuronate isomerase; Region: UxaC; pfam02614
439843009403	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
439843009404	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
439843009405	dimer interface [polypeptide binding]; other site
439843009406	putative CheW interface [polypeptide binding]; other site
439843009407	MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682
439843009408	bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507
439843009409	CHAP domain; Region: CHAP; pfam05257
439843009410	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
439843009411	putative S-transferase; Provisional; Region: PRK11752
439843009412	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
439843009413	C-terminal domain interface [polypeptide binding]; other site
439843009414	GSH binding site (G-site) [chemical binding]; other site
439843009415	dimer interface [polypeptide binding]; other site
439843009416	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
439843009417	dimer interface [polypeptide binding]; other site
439843009418	N-terminal domain interface [polypeptide binding]; other site
439843009419	active site
439843009420	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
439843009421	molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537
439843009422	Periplasmic binding protein TroA_e.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142
439843009423	putative ligand binding residues [chemical binding]; other site
439843009424	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
439843009425	hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413
439843009426	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
439843009427	hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380
439843009428	hydrogenase 2-specific chaperone; Provisional; Region: PRK10465
439843009429	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
439843009430	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
439843009431	putative substrate-binding site; other site
439843009432	nickel binding site [ion binding]; other site
439843009433	hydrogenase 2 large subunit; Provisional; Region: PRK10467
439843009434	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
439843009435	putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881
439843009436	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
439843009437	hydrogenase 2 protein HybA; Provisional; Region: PRK10882
439843009438	4Fe-4S binding domain; Region: Fer4_6; pfam12837
439843009439	hydrogenase 2 small subunit; Provisional; Region: PRK10468
439843009440	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
439843009441	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
439843009442	Protein of unknown function (DUF2623); Region: DUF2623; pfam11115
439843009443	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
439843009444	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
439843009445	dimerization interface [polypeptide binding]; other site
439843009446	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
439843009447	dimer interface [polypeptide binding]; other site
439843009448	putative CheW interface [polypeptide binding]; other site
439843009449	hypothetical protein; Provisional; Region: PRK05208
439843009450	oxidoreductase; Provisional; Region: PRK07985
439843009451	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
439843009452	NAD binding site [chemical binding]; other site
439843009453	metal binding site [ion binding]; metal-binding site
439843009454	active site
439843009455	biopolymer transport protein ExbD; Provisional; Region: PRK11267
439843009456	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
439843009457	biopolymer transport protein ExbB; Provisional; Region: PRK10414
439843009458	cystathionine beta-lyase; Provisional; Region: PRK08114
439843009459	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
439843009460	homodimer interface [polypeptide binding]; other site
439843009461	substrate-cofactor binding pocket; other site
439843009462	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843009463	catalytic residue [active]
439843009464	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
439843009465	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
439843009466	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
439843009467	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
439843009468	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439843009469	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439843009470	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
439843009471	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
439843009472	dimer interface [polypeptide binding]; other site
439843009473	active site
439843009474	metal binding site [ion binding]; metal-binding site
439843009475	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
439843009476	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
439843009477	active site
439843009478	catalytic tetrad [active]
439843009479	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
439843009480	nucleotide binding site/active site [active]
439843009481	catalytic residue [active]
439843009482	hypothetical protein; Provisional; Region: PRK01254
439843009483	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
439843009484	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
439843009485	YARHG domain; Region: YARHG; pfam13308
439843009486	FtsI repressor; Provisional; Region: PRK10883
439843009487	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
439843009488	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
439843009489	1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018
439843009490	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
439843009491	putative acyl-acceptor binding pocket; other site
439843009492	DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062
439843009493	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
439843009494	CAP-like domain; other site
439843009495	active site
439843009496	primary dimer interface [polypeptide binding]; other site
439843009497	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
439843009498	Periplasmic protein with OB-fold [Function unknown]; Region: COG3111
439843009499	DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336
439843009500	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843009501	active site
439843009502	phosphorylation site [posttranslational modification]
439843009503	intermolecular recognition site; other site
439843009504	dimerization interface [polypeptide binding]; other site
439843009505	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
439843009506	DNA binding site [nucleotide binding]
439843009507	sensor protein QseC; Provisional; Region: PRK10337
439843009508	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
439843009509	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439843009510	dimer interface [polypeptide binding]; other site
439843009511	phosphorylation site [posttranslational modification]
439843009512	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439843009513	ATP binding site [chemical binding]; other site
439843009514	Mg2+ binding site [ion binding]; other site
439843009515	G-X-G motif; other site
439843009516	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
439843009517	Uncharacterized conserved protein [Function unknown]; Region: COG1359
439843009518	DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055
439843009519	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439843009520	ATP binding site [chemical binding]; other site
439843009521	Mg2+ binding site [ion binding]; other site
439843009522	G-X-G motif; other site
439843009523	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
439843009524	anchoring element; other site
439843009525	dimer interface [polypeptide binding]; other site
439843009526	ATP binding site [chemical binding]; other site
439843009527	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
439843009528	active site
439843009529	metal binding site [ion binding]; metal-binding site
439843009530	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
439843009531	esterase YqiA; Provisional; Region: PRK11071
439843009532	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
439843009533	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
439843009534	active site
439843009535	metal binding site [ion binding]; metal-binding site
439843009536	hexamer interface [polypeptide binding]; other site
439843009537	putative dehydrogenase; Provisional; Region: PRK11039
439843009538	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
439843009539	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
439843009540	dimer interface [polypeptide binding]; other site
439843009541	ADP-ribose binding site [chemical binding]; other site
439843009542	active site
439843009543	nudix motif; other site
439843009544	metal binding site [ion binding]; metal-binding site
439843009545	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
439843009546	hypothetical protein; Provisional; Region: PRK11653
439843009547	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
439843009548	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
439843009549	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
439843009550	putative active site [active]
439843009551	metal binding site [ion binding]; metal-binding site
439843009552	zinc transporter ZupT; Provisional; Region: PRK04201
439843009553	ZIP Zinc transporter; Region: Zip; pfam02535
439843009554	Protein of unknown function (DUF4051); Region: DUF4051; pfam13260
439843009555	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
439843009556	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
439843009557	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
439843009558	catalytic residues [active]
439843009559	hinge region; other site
439843009560	alpha helical domain; other site
439843009561	putative disulfide oxidoreductase; Provisional; Region: PRK04307
439843009562	Homeodomain-like domain; Region: HTH_23; cl17451
439843009563	Integrase core domain; Region: rve; pfam00665
439843009564	Integrase core domain; Region: rve_3; pfam13683
439843009565	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
439843009566	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
439843009567	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960
439843009568	glycogen synthesis protein GlgS; Provisional; Region: PRK02922
439843009569	Protein of unknown function (DUF1449); Region: DUF1449; pfam07290
439843009570	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
439843009571	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
439843009572	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
439843009573	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
439843009574	putative ribose interaction site [chemical binding]; other site
439843009575	putative ADP binding site [chemical binding]; other site
439843009576	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
439843009577	active site
439843009578	nucleotide binding site [chemical binding]; other site
439843009579	HIGH motif; other site
439843009580	KMSKS motif; other site
439843009581	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
439843009582	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
439843009583	metal binding triad; other site
439843009584	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
439843009585	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
439843009586	metal binding triad; other site
439843009587	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
439843009588	Uncharacterized conserved protein [Function unknown]; Region: COG3025
439843009589	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
439843009590	putative active site [active]
439843009591	putative metal binding residues [ion binding]; other site
439843009592	signature motif; other site
439843009593	putative triphosphate binding site [ion binding]; other site
439843009594	CHAD domain; Region: CHAD; pfam05235
439843009595	SH3 domain-containing protein; Provisional; Region: PRK10884
439843009596	Bacterial SH3 domain homologues; Region: SH3b; smart00287
439843009597	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
439843009598	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
439843009599	active site
439843009600	NTP binding site [chemical binding]; other site
439843009601	metal binding triad [ion binding]; metal-binding site
439843009602	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
439843009603	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
439843009604	Zn2+ binding site [ion binding]; other site
439843009605	Mg2+ binding site [ion binding]; other site
439843009606	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
439843009607	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
439843009608	homooctamer interface [polypeptide binding]; other site
439843009609	active site
439843009610	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
439843009611	UGMP family protein; Validated; Region: PRK09604
439843009612	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
439843009613	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
439843009614	DNA primase; Validated; Region: dnaG; PRK05667
439843009615	CHC2 zinc finger; Region: zf-CHC2; pfam01807
439843009616	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
439843009617	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
439843009618	active site
439843009619	metal binding site [ion binding]; metal-binding site
439843009620	interdomain interaction site; other site
439843009621	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
439843009622	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
439843009623	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
439843009624	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
439843009625	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
439843009626	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
439843009627	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
439843009628	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
439843009629	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
439843009630	DNA binding residues [nucleotide binding]
439843009631	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
439843009632	active site
439843009633	SUMO-1 interface [polypeptide binding]; other site
439843009634	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
439843009635	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
439843009636	FAD binding pocket [chemical binding]; other site
439843009637	FAD binding motif [chemical binding]; other site
439843009638	phosphate binding motif [ion binding]; other site
439843009639	NAD binding pocket [chemical binding]; other site
439843009640	Predicted transcriptional regulators [Transcription]; Region: COG1695
439843009641	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
439843009642	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
439843009643	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
439843009644	dimerization interface [polypeptide binding]; other site
439843009645	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
439843009646	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
439843009647	dimer interface [polypeptide binding]; other site
439843009648	putative CheW interface [polypeptide binding]; other site
439843009649	PAS fold; Region: PAS_3; pfam08447
439843009650	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
439843009651	putative active site [active]
439843009652	heme pocket [chemical binding]; other site
439843009653	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
439843009654	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
439843009655	dimer interface [polypeptide binding]; other site
439843009656	putative CheW interface [polypeptide binding]; other site
439843009657	putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522
439843009658	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
439843009659	inhibitor-cofactor binding pocket; inhibition site
439843009660	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843009661	catalytic residue [active]
439843009662	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
439843009663	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
439843009664	active site
439843009665	FMN binding site [chemical binding]; other site
439843009666	2,4-decadienoyl-CoA binding site; other site
439843009667	catalytic residue [active]
439843009668	4Fe-4S cluster binding site [ion binding]; other site
439843009669	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
439843009670	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
439843009671	SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001
439843009672	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439843009673	S-adenosylmethionine binding site [chemical binding]; other site
439843009674	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
439843009675	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
439843009676	putative active site [active]
439843009677	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
439843009678	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
439843009679	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
439843009680	serine/threonine transporter SstT; Provisional; Region: PRK13628
439843009681	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
439843009682	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
439843009683	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
439843009684	EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629
439843009685	Protein of unknown function (DUF1090); Region: DUF1090; pfam06476
439843009686	Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575
439843009687	Predicted membrane protein [Function unknown]; Region: COG5393
439843009688	YqjK-like protein; Region: YqjK; pfam13997
439843009689	Predicted membrane protein [Function unknown]; Region: COG2259
439843009690	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
439843009691	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
439843009692	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
439843009693	putative dimer interface [polypeptide binding]; other site
439843009694	N-terminal domain interface [polypeptide binding]; other site
439843009695	putative substrate binding pocket (H-site) [chemical binding]; other site
439843009696	Predicted membrane protein [Function unknown]; Region: COG3152
439843009697	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843009698	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
439843009699	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
439843009700	dimerization interface [polypeptide binding]; other site
439843009701	Pirin-related protein [General function prediction only]; Region: COG1741
439843009702	Pirin; Region: Pirin; pfam02678
439843009703	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
439843009704	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
439843009705	serine transporter; Region: stp; TIGR00814
439843009706	L-serine dehydratase TdcG; Provisional; Region: PRK15040
439843009707	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
439843009708	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
439843009709	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
439843009710	Pyruvate formate lyase 1; Region: PFL1; cd01678
439843009711	coenzyme A binding site [chemical binding]; other site
439843009712	active site
439843009713	catalytic residues [active]
439843009714	glycine loop; other site
439843009715	propionate/acetate kinase; Provisional; Region: PRK12379
439843009716	Acetate kinase [Energy production and conversion]; Region: ackA; COG0282
439843009717	threonine/serine transporter TdcC; Provisional; Region: PRK13629
439843009718	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
439843009719	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
439843009720	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
439843009721	tetramer interface [polypeptide binding]; other site
439843009722	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843009723	catalytic residue [active]
439843009724	DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341
439843009725	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843009726	The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418
439843009727	putative substrate binding pocket [chemical binding]; other site
439843009728	putative dimerization interface [polypeptide binding]; other site
439843009729	glycerate kinase I; Provisional; Region: PRK10342
439843009730	tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559
439843009731	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
439843009732	alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558
439843009733	galactarate dehydratase; Region: galactar-dH20; TIGR03248
439843009734	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
439843009735	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
439843009736	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
439843009737	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
439843009738	intersubunit interface [polypeptide binding]; other site
439843009739	active site
439843009740	zinc binding site [ion binding]; other site
439843009741	Na+ binding site [ion binding]; other site
439843009742	D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052
439843009743	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
439843009744	active site
439843009745	phosphorylation site [posttranslational modification]
439843009746	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
439843009747	active site
439843009748	P-loop; other site
439843009749	phosphorylation site [posttranslational modification]
439843009750	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
439843009751	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
439843009752	galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309
439843009753	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
439843009754	putative NAD(P) binding site [chemical binding]; other site
439843009755	catalytic Zn binding site [ion binding]; other site
439843009756	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
439843009757	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
439843009758	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
439843009759	SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994
439843009760	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
439843009761	putative SAM binding site [chemical binding]; other site
439843009762	putative homodimer interface [polypeptide binding]; other site
439843009763	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
439843009764	Putative lipoprotein [General function prediction only]; Region: LppC; COG3107
439843009765	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
439843009766	putative ligand binding site [chemical binding]; other site
439843009767	TIGR00252 family protein; Region: TIGR00252
439843009768	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
439843009769	dimer interface [polypeptide binding]; other site
439843009770	active site
439843009771	outer membrane lipoprotein; Provisional; Region: PRK11023
439843009772	BON domain; Region: BON; pfam04972
439843009773	BON domain; Region: BON; pfam04972
439843009774	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
439843009775	NADH(P)-binding; Region: NAD_binding_10; pfam13460
439843009776	NAD binding site [chemical binding]; other site
439843009777	active site
439843009778	intracellular protease, PfpI family; Region: PfpI; TIGR01382
439843009779	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
439843009780	proposed catalytic triad [active]
439843009781	conserved cys residue [active]
439843009782	hypothetical protein; Provisional; Region: PRK03467
439843009783	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
439843009784	GIY-YIG motif/motif A; other site
439843009785	putative active site [active]
439843009786	putative metal binding site [ion binding]; other site
439843009787	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
439843009788	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
439843009789	Coenzyme A binding pocket [chemical binding]; other site
439843009790	Putative lipid carrier protein [Lipid metabolism]; Region: COG3154
439843009791	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
439843009792	Peptidase family U32; Region: Peptidase_U32; pfam01136
439843009793	putative protease; Provisional; Region: PRK15447
439843009794	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
439843009795	hypothetical protein; Provisional; Region: PRK10508
439843009796	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
439843009797	tryptophan permease; Provisional; Region: PRK10483
439843009798	aromatic amino acid transport protein; Region: araaP; TIGR00837
439843009799	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
439843009800	DEAD-like helicases superfamily; Region: DEXDc; smart00487
439843009801	ATP binding site [chemical binding]; other site
439843009802	Mg++ binding site [ion binding]; other site
439843009803	motif III; other site
439843009804	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
439843009805	nucleotide binding region [chemical binding]; other site
439843009806	ATP-binding site [chemical binding]; other site
439843009807	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
439843009808	putative RNA binding site [nucleotide binding]; other site
439843009809	lipoprotein NlpI; Provisional; Region: PRK11189
439843009810	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
439843009811	binding surface
439843009812	TPR motif; other site
439843009813	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
439843009814	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
439843009815	RNase E interface [polypeptide binding]; other site
439843009816	trimer interface [polypeptide binding]; other site
439843009817	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
439843009818	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
439843009819	RNase E interface [polypeptide binding]; other site
439843009820	trimer interface [polypeptide binding]; other site
439843009821	active site
439843009822	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
439843009823	putative nucleic acid binding region [nucleotide binding]; other site
439843009824	G-X-X-G motif; other site
439843009825	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
439843009826	RNA binding site [nucleotide binding]; other site
439843009827	domain interface; other site
439843009828	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
439843009829	16S/18S rRNA binding site [nucleotide binding]; other site
439843009830	S13e-L30e interaction site [polypeptide binding]; other site
439843009831	25S rRNA binding site [nucleotide binding]; other site
439843009832	Ribosomal S15 leader
439843009833	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
439843009834	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
439843009835	RNA binding site [nucleotide binding]; other site
439843009836	active site
439843009837	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
439843009838	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
439843009839	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
439843009840	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
439843009841	translation initiation factor IF-2; Region: IF-2; TIGR00487
439843009842	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
439843009843	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
439843009844	G1 box; other site
439843009845	putative GEF interaction site [polypeptide binding]; other site
439843009846	GTP/Mg2+ binding site [chemical binding]; other site
439843009847	Switch I region; other site
439843009848	G2 box; other site
439843009849	G3 box; other site
439843009850	Switch II region; other site
439843009851	G4 box; other site
439843009852	G5 box; other site
439843009853	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
439843009854	Translation-initiation factor 2; Region: IF-2; pfam11987
439843009855	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
439843009856	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
439843009857	NusA N-terminal domain; Region: NusA_N; pfam08529
439843009858	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
439843009859	RNA binding site [nucleotide binding]; other site
439843009860	homodimer interface [polypeptide binding]; other site
439843009861	NusA-like KH domain; Region: KH_5; pfam13184
439843009862	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
439843009863	G-X-X-G motif; other site
439843009864	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
439843009865	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
439843009866	ribosome maturation protein RimP; Reviewed; Region: PRK00092
439843009867	Sm and related proteins; Region: Sm_like; cl00259
439843009868	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
439843009869	putative oligomer interface [polypeptide binding]; other site
439843009870	putative RNA binding site [nucleotide binding]; other site
439843009871	argininosuccinate synthase; Validated; Region: PRK05370
439843009872	argininosuccinate synthase; Provisional; Region: PRK13820
439843009873	Preprotein translocase SecG subunit; Region: SecG; pfam03840
439843009874	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
439843009875	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
439843009876	active site
439843009877	substrate binding site [chemical binding]; other site
439843009878	metal binding site [ion binding]; metal-binding site
439843009879	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
439843009880	dihydropteroate synthase; Region: DHPS; TIGR01496
439843009881	substrate binding pocket [chemical binding]; other site
439843009882	dimer interface [polypeptide binding]; other site
439843009883	inhibitor binding site; inhibition site
439843009884	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
439843009885	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439843009886	Walker A motif; other site
439843009887	ATP binding site [chemical binding]; other site
439843009888	Walker B motif; other site
439843009889	arginine finger; other site
439843009890	Peptidase family M41; Region: Peptidase_M41; pfam01434
439843009891	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
439843009892	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439843009893	S-adenosylmethionine binding site [chemical binding]; other site
439843009894	RNA-binding protein YhbY; Provisional; Region: PRK10343
439843009895	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
439843009896	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
439843009897	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
439843009898	D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113
439843009899	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
439843009900	GTPase CgtA; Reviewed; Region: obgE; PRK12298
439843009901	GTP1/OBG; Region: GTP1_OBG; pfam01018
439843009902	Obg GTPase; Region: Obg; cd01898
439843009903	G1 box; other site
439843009904	GTP/Mg2+ binding site [chemical binding]; other site
439843009905	Switch I region; other site
439843009906	G2 box; other site
439843009907	G3 box; other site
439843009908	Switch II region; other site
439843009909	G4 box; other site
439843009910	G5 box; other site
439843009911	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
439843009912	EamA-like transporter family; Region: EamA; pfam00892
439843009913	EamA-like transporter family; Region: EamA; pfam00892
439843009914	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
439843009915	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
439843009916	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
439843009917	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
439843009918	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
439843009919	substrate binding pocket [chemical binding]; other site
439843009920	chain length determination region; other site
439843009921	substrate-Mg2+ binding site; other site
439843009922	catalytic residues [active]
439843009923	aspartate-rich region 1; other site
439843009924	active site lid residues [active]
439843009925	aspartate-rich region 2; other site
439843009926	DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344
439843009927	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
439843009928	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
439843009929	hinge; other site
439843009930	active site
439843009931	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
439843009932	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
439843009933	anti sigma factor interaction site; other site
439843009934	regulatory phosphorylation site [posttranslational modification]; other site
439843009935	ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117
439843009936	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
439843009937	mce related protein; Region: MCE; pfam02470
439843009938	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
439843009939	conserved hypothetical integral membrane protein; Region: TIGR00056
439843009940	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
439843009941	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
439843009942	Walker A/P-loop; other site
439843009943	ATP binding site [chemical binding]; other site
439843009944	Q-loop/lid; other site
439843009945	ABC transporter signature motif; other site
439843009946	Walker B; other site
439843009947	D-loop; other site
439843009948	H-loop/switch region; other site
439843009949	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
439843009950	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
439843009951	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
439843009952	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
439843009953	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
439843009954	putative active site [active]
439843009955	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
439843009956	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484
439843009957	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
439843009958	lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893
439843009959	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
439843009960	lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894
439843009961	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
439843009962	lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895
439843009963	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
439843009964	Walker A/P-loop; other site
439843009965	ATP binding site [chemical binding]; other site
439843009966	Q-loop/lid; other site
439843009967	ABC transporter signature motif; other site
439843009968	Walker B; other site
439843009969	D-loop; other site
439843009970	H-loop/switch region; other site
439843009971	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
439843009972	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
439843009973	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
439843009974	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
439843009975	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
439843009976	30S subunit binding site; other site
439843009977	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
439843009978	active site
439843009979	phosphorylation site [posttranslational modification]
439843009980	P-loop ATPase protein family; Region: ATP_bind_2; cl15794
439843009981	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
439843009982	dimerization domain swap beta strand [polypeptide binding]; other site
439843009983	regulatory protein interface [polypeptide binding]; other site
439843009984	active site
439843009985	regulatory phosphorylation site [posttranslational modification]; other site
439843009986	hypothetical protein; Provisional; Region: PRK10345
439843009987	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
439843009988	Transglycosylase; Region: Transgly; cl17702
439843009989	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
439843009990	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
439843009991	conserved cys residue [active]
439843009992	aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091
439843009993	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
439843009994	putative active site [active]
439843009995	heme pocket [chemical binding]; other site
439843009996	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439843009997	dimer interface [polypeptide binding]; other site
439843009998	phosphorylation site [posttranslational modification]
439843009999	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439843010000	ATP binding site [chemical binding]; other site
439843010001	Mg2+ binding site [ion binding]; other site
439843010002	G-X-G motif; other site
439843010003	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843010004	active site
439843010005	phosphorylation site [posttranslational modification]
439843010006	intermolecular recognition site; other site
439843010007	dimerization interface [polypeptide binding]; other site
439843010008	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
439843010009	putative binding surface; other site
439843010010	active site
439843010011	radical SAM protein, TIGR01212 family; Region: TIGR01212
439843010012	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439843010013	FeS/SAM binding site; other site
439843010014	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
439843010015	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
439843010016	active site
439843010017	dimer interface [polypeptide binding]; other site
439843010018	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
439843010019	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
439843010020	active site
439843010021	FMN binding site [chemical binding]; other site
439843010022	substrate binding site [chemical binding]; other site
439843010023	3Fe-4S cluster binding site [ion binding]; other site
439843010024	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
439843010025	domain interface; other site
439843010026	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
439843010027	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
439843010028	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
439843010029	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
439843010030	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
439843010031	nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484
439843010032	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
439843010033	Na binding site [ion binding]; other site
439843010034	putative substrate binding site [chemical binding]; other site
439843010035	cytosine deaminase; Provisional; Region: PRK09230
439843010036	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
439843010037	active site
439843010038	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
439843010039	N-acetylmannosamine kinase; Provisional; Region: PRK05082
439843010040	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
439843010041	nucleotide binding site [chemical binding]; other site
439843010042	Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010
439843010043	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
439843010044	putative active site cavity [active]
439843010045	putative sialic acid transporter; Provisional; Region: PRK03893
439843010046	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843010047	putative substrate translocation pore; other site
439843010048	N-acetylneuraminate lyase; Provisional; Region: PRK04147
439843010049	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
439843010050	inhibitor site; inhibition site
439843010051	active site
439843010052	dimer interface [polypeptide binding]; other site
439843010053	catalytic residue [active]
439843010054	transcriptional regulator NanR; Provisional; Region: PRK03837
439843010055	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439843010056	DNA-binding site [nucleotide binding]; DNA binding site
439843010057	FCD domain; Region: FCD; pfam07729
439843010058	Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969
439843010059	stringent starvation protein A; Provisional; Region: sspA; PRK09481
439843010060	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
439843010061	C-terminal domain interface [polypeptide binding]; other site
439843010062	putative GSH binding site (G-site) [chemical binding]; other site
439843010063	dimer interface [polypeptide binding]; other site
439843010064	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
439843010065	dimer interface [polypeptide binding]; other site
439843010066	N-terminal domain interface [polypeptide binding]; other site
439843010067	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
439843010068	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
439843010069	23S rRNA interface [nucleotide binding]; other site
439843010070	L3 interface [polypeptide binding]; other site
439843010071	Predicted ATPase [General function prediction only]; Region: COG1485
439843010072	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105
439843010073	hypothetical protein; Provisional; Region: PRK11677
439843010074	serine endoprotease; Provisional; Region: PRK10139
439843010075	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
439843010076	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
439843010077	protein binding site [polypeptide binding]; other site
439843010078	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
439843010079	serine endoprotease; Provisional; Region: PRK10898
439843010080	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
439843010081	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
439843010082	Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767
439843010083	oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476
439843010084	oxaloacetate decarboxylase; Provisional; Region: PRK14040
439843010085	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
439843010086	active site
439843010087	catalytic residues [active]
439843010088	metal binding site [ion binding]; metal-binding site
439843010089	homodimer binding site [polypeptide binding]; other site
439843010090	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
439843010091	carboxyltransferase (CT) interaction site; other site
439843010092	biotinylation site [posttranslational modification]; other site
439843010093	oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919
439843010094	L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228
439843010095	tartrate dehydratase subunit alpha; Validated; Region: PRK08230
439843010096	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
439843010097	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
439843010098	transmembrane helices; other site
439843010099	Transcriptional regulators [Transcription]; Region: GntR; COG1802
439843010100	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439843010101	DNA-binding site [nucleotide binding]; DNA binding site
439843010102	FCD domain; Region: FCD; pfam07729
439843010103	Transcriptional regulators [Transcription]; Region: GntR; COG1802
439843010104	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439843010105	DNA-binding site [nucleotide binding]; DNA binding site
439843010106	malate dehydrogenase; Provisional; Region: PRK05086
439843010107	Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337
439843010108	NAD binding site [chemical binding]; other site
439843010109	dimerization interface [polypeptide binding]; other site
439843010110	Substrate binding site [chemical binding]; other site
439843010111	arginine repressor; Provisional; Region: PRK05066
439843010112	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
439843010113	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
439843010114	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
439843010115	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
439843010116	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142
439843010117	RNAase interaction site [polypeptide binding]; other site
439843010118	p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631
439843010119	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
439843010120	p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559
439843010121	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
439843010122	HlyD family secretion protein; Region: HlyD_3; pfam13437
439843010123	efflux system membrane protein; Provisional; Region: PRK11594
439843010124	transcriptional regulator; Provisional; Region: PRK10632
439843010125	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843010126	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
439843010127	putative effector binding pocket; other site
439843010128	dimerization interface [polypeptide binding]; other site
439843010129	protease TldD; Provisional; Region: tldD; PRK10735
439843010130	hypothetical protein; Provisional; Region: PRK10899
439843010131	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
439843010132	ribonuclease G; Provisional; Region: PRK11712
439843010133	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
439843010134	homodimer interface [polypeptide binding]; other site
439843010135	oligonucleotide binding site [chemical binding]; other site
439843010136	Maf-like protein; Region: Maf; pfam02545
439843010137	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
439843010138	active site
439843010139	dimer interface [polypeptide binding]; other site
439843010140	rod shape-determining protein MreD; Provisional; Region: PRK11060
439843010141	rod shape-determining protein MreC; Region: mreC; TIGR00219
439843010142	rod shape-determining protein MreC; Region: MreC; pfam04085
439843010143	rod shape-determining protein MreB; Provisional; Region: PRK13927
439843010144	MreB and similar proteins; Region: MreB_like; cd10225
439843010145	nucleotide binding site [chemical binding]; other site
439843010146	Mg binding site [ion binding]; other site
439843010147	putative protofilament interaction site [polypeptide binding]; other site
439843010148	RodZ interaction site [polypeptide binding]; other site
439843010149	regulatory protein CsrD; Provisional; Region: PRK11059
439843010150	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
439843010151	metal binding site [ion binding]; metal-binding site
439843010152	active site
439843010153	I-site; other site
439843010154	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
439843010155	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
439843010156	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
439843010157	NADP binding site [chemical binding]; other site
439843010158	dimer interface [polypeptide binding]; other site
439843010159	TMAO/DMSO reductase; Reviewed; Region: PRK05363
439843010160	YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107
439843010161	Moco binding site; other site
439843010162	metal coordination site [ion binding]; other site
439843010163	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
439843010164	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
439843010165	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
439843010166	carboxyltransferase (CT) interaction site; other site
439843010167	biotinylation site [posttranslational modification]; other site
439843010168	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
439843010169	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
439843010170	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
439843010171	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
439843010172	hypothetical protein; Provisional; Region: PRK10633
439843010173	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
439843010174	Na binding site [ion binding]; other site
439843010175	ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406
439843010176	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
439843010177	tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415
439843010178	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
439843010179	FMN binding site [chemical binding]; other site
439843010180	active site
439843010181	catalytic residues [active]
439843010182	substrate binding site [chemical binding]; other site
439843010183	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
439843010184	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
439843010185	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
439843010186	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439843010187	DNA methylase; Region: N6_N4_Mtase; pfam01555
439843010188	Protein of unknown function (DUF2556); Region: DUF2556; pfam10831
439843010189	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
439843010190	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
439843010191	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
439843010192	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
439843010193	metal binding site [ion binding]; metal-binding site
439843010194	active site
439843010195	I-site; other site
439843010196	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
439843010197	DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975
439843010198	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
439843010199	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
439843010200	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
439843010201	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
439843010202	HlyD family secretion protein; Region: HlyD_3; pfam13437
439843010203	multidrug efflux system protein AcrB; Provisional; Region: PRK15127
439843010204	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
439843010205	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
439843010206	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
439843010207	trimer interface [polypeptide binding]; other site
439843010208	putative metal binding site [ion binding]; other site
439843010209	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
439843010210	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
439843010211	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
439843010212	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
439843010213	shikimate binding site; other site
439843010214	NAD(P) binding site [chemical binding]; other site
439843010215	tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634
439843010216	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
439843010217	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
439843010218	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
439843010219	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
439843010220	hypothetical protein; Validated; Region: PRK03430
439843010221	hypothetical protein; Provisional; Region: PRK10736
439843010222	DNA protecting protein DprA; Region: dprA; TIGR00732
439843010223	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
439843010224	active site
439843010225	catalytic residues [active]
439843010226	metal binding site [ion binding]; metal-binding site
439843010227	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
439843010228	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
439843010229	putative active site [active]
439843010230	substrate binding site [chemical binding]; other site
439843010231	putative cosubstrate binding site; other site
439843010232	catalytic site [active]
439843010233	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
439843010234	substrate binding site [chemical binding]; other site
439843010235	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
439843010236	putative RNA binding site [nucleotide binding]; other site
439843010237	16S rRNA methyltransferase B; Provisional; Region: PRK10901
439843010238	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439843010239	S-adenosylmethionine binding site [chemical binding]; other site
439843010240	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
439843010241	TrkA-N domain; Region: TrkA_N; pfam02254
439843010242	TrkA-C domain; Region: TrkA_C; pfam02080
439843010243	TrkA-N domain; Region: TrkA_N; pfam02254
439843010244	TrkA-C domain; Region: TrkA_C; pfam02080
439843010245	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
439843010246	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
439843010247	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
439843010248	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
439843010249	DNA binding residues [nucleotide binding]
439843010250	dimer interface [polypeptide binding]; other site
439843010251	metal binding site [ion binding]; metal-binding site
439843010252	hypothetical protein; Provisional; Region: PRK10203
439843010253	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
439843010254	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
439843010255	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
439843010256	alphaNTD homodimer interface [polypeptide binding]; other site
439843010257	alphaNTD - beta interaction site [polypeptide binding]; other site
439843010258	alphaNTD - beta' interaction site [polypeptide binding]; other site
439843010259	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
439843010260	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
439843010261	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
439843010262	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
439843010263	RNA binding surface [nucleotide binding]; other site
439843010264	30S ribosomal protein S11; Validated; Region: PRK05309
439843010265	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
439843010266	30S ribosomal protein S13; Region: bact_S13; TIGR03631
439843010267	Alpha operon ribosome binding site
439843010268	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
439843010269	SecY translocase; Region: SecY; pfam00344
439843010270	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
439843010271	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
439843010272	23S rRNA binding site [nucleotide binding]; other site
439843010273	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
439843010274	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
439843010275	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
439843010276	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
439843010277	23S rRNA interface [nucleotide binding]; other site
439843010278	5S rRNA interface [nucleotide binding]; other site
439843010279	L27 interface [polypeptide binding]; other site
439843010280	L5 interface [polypeptide binding]; other site
439843010281	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
439843010282	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
439843010283	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
439843010284	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
439843010285	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
439843010286	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
439843010287	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
439843010288	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
439843010289	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
439843010290	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
439843010291	RNA binding site [nucleotide binding]; other site
439843010292	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
439843010293	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
439843010294	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
439843010295	23S rRNA interface [nucleotide binding]; other site
439843010296	putative translocon interaction site; other site
439843010297	signal recognition particle (SRP54) interaction site; other site
439843010298	L23 interface [polypeptide binding]; other site
439843010299	trigger factor interaction site; other site
439843010300	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
439843010301	23S rRNA interface [nucleotide binding]; other site
439843010302	5S rRNA interface [nucleotide binding]; other site
439843010303	putative antibiotic binding site [chemical binding]; other site
439843010304	L25 interface [polypeptide binding]; other site
439843010305	L27 interface [polypeptide binding]; other site
439843010306	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
439843010307	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
439843010308	G-X-X-G motif; other site
439843010309	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
439843010310	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
439843010311	protein-rRNA interface [nucleotide binding]; other site
439843010312	putative translocon binding site; other site
439843010313	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
439843010314	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
439843010315	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
439843010316	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
439843010317	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
439843010318	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
439843010319	50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625
439843010320	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
439843010321	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
439843010322	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
439843010323	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
439843010324	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
439843010325	heme binding site [chemical binding]; other site
439843010326	ferroxidase pore; other site
439843010327	ferroxidase diiron center [ion binding]; other site
439843010328	bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509
439843010329	elongation factor Tu; Reviewed; Region: PRK00049
439843010330	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
439843010331	G1 box; other site
439843010332	GEF interaction site [polypeptide binding]; other site
439843010333	GTP/Mg2+ binding site [chemical binding]; other site
439843010334	Switch I region; other site
439843010335	G2 box; other site
439843010336	G3 box; other site
439843010337	Switch II region; other site
439843010338	G4 box; other site
439843010339	G5 box; other site
439843010340	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
439843010341	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
439843010342	Antibiotic Binding Site [chemical binding]; other site
439843010343	elongation factor G; Reviewed; Region: PRK00007
439843010344	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
439843010345	G1 box; other site
439843010346	putative GEF interaction site [polypeptide binding]; other site
439843010347	GTP/Mg2+ binding site [chemical binding]; other site
439843010348	Switch I region; other site
439843010349	G2 box; other site
439843010350	G3 box; other site
439843010351	Switch II region; other site
439843010352	G4 box; other site
439843010353	G5 box; other site
439843010354	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
439843010355	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
439843010356	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
439843010357	30S ribosomal protein S7; Validated; Region: PRK05302
439843010358	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
439843010359	S17 interaction site [polypeptide binding]; other site
439843010360	S8 interaction site; other site
439843010361	16S rRNA interaction site [nucleotide binding]; other site
439843010362	streptomycin interaction site [chemical binding]; other site
439843010363	23S rRNA interaction site [nucleotide binding]; other site
439843010364	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
439843010365	sulfur transfer complex subunit TusB; Provisional; Region: PRK13510
439843010366	sulfur relay protein TusC; Validated; Region: PRK00211
439843010367	sulfur transfer complex subunit TusD; Validated; Region: PRK00207
439843010368	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
439843010369	YheO-like PAS domain; Region: PAS_6; pfam08348
439843010370	HTH domain; Region: HTH_22; pfam13309
439843010371	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902
439843010372	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
439843010373	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
439843010374	phi X174 lysis protein; Provisional; Region: PRK02793
439843010375	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
439843010376	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
439843010377	Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529
439843010378	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
439843010379	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
439843010380	TrkA-N domain; Region: TrkA_N; pfam02254
439843010381	glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930
439843010382	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
439843010383	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439843010384	Walker A/P-loop; other site
439843010385	ATP binding site [chemical binding]; other site
439843010386	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
439843010387	ABC transporter signature motif; other site
439843010388	Walker B; other site
439843010389	D-loop; other site
439843010390	ABC transporter; Region: ABC_tran_2; pfam12848
439843010391	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
439843010392	Transcriptional regulator [Transcription]; Region: LysR; COG0583
439843010393	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843010394	putative monooxygenase; Provisional; Region: PRK11118
439843010395	putative hydrolase; Provisional; Region: PRK10985
439843010396	hypothetical protein; Provisional; Region: PRK04966
439843010397	Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029
439843010398	active site
439843010399	hypothetical protein; Provisional; Region: PRK10738
439843010400	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
439843010401	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
439843010402	ligand binding site [chemical binding]; other site
439843010403	flexible hinge region; other site
439843010404	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
439843010405	putative switch regulator; other site
439843010406	non-specific DNA interactions [nucleotide binding]; other site
439843010407	DNA binding site [nucleotide binding]
439843010408	sequence specific DNA binding site [nucleotide binding]; other site
439843010409	putative cAMP binding site [chemical binding]; other site
439843010410	integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667
439843010411	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
439843010412	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
439843010413	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
439843010414	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
439843010415	inhibitor-cofactor binding pocket; inhibition site
439843010416	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843010417	catalytic residue [active]
439843010418	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
439843010419	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
439843010420	glutamine binding [chemical binding]; other site
439843010421	catalytic triad [active]
439843010422	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
439843010423	cell filamentation protein Fic; Provisional; Region: PRK10347
439843010424	hypothetical protein; Provisional; Region: PRK10204
439843010425	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
439843010426	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
439843010427	substrate binding site [chemical binding]; other site
439843010428	putative transporter; Provisional; Region: PRK03699
439843010429	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843010430	putative substrate translocation pore; other site
439843010431	nitrite reductase subunit NirD; Provisional; Region: PRK14989
439843010432	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
439843010433	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
439843010434	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
439843010435	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
439843010436	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
439843010437	nitrite transporter NirC; Provisional; Region: PRK11562
439843010438	siroheme synthase; Provisional; Region: cysG; PRK10637
439843010439	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
439843010440	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
439843010441	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
439843010442	active site
439843010443	SAM binding site [chemical binding]; other site
439843010444	homodimer interface [polypeptide binding]; other site
439843010445	Autotransporter beta-domain; Region: Autotransporter; pfam03797
439843010446	Protein of unknown function (DUF4223); Region: DUF4223; pfam13978
439843010447	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
439843010448	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
439843010449	active site
439843010450	HIGH motif; other site
439843010451	dimer interface [polypeptide binding]; other site
439843010452	KMSKS motif; other site
439843010453	phosphoglycolate phosphatase; Provisional; Region: PRK13222
439843010454	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439843010455	motif II; other site
439843010456	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
439843010457	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
439843010458	substrate binding site [chemical binding]; other site
439843010459	hexamer interface [polypeptide binding]; other site
439843010460	metal binding site [ion binding]; metal-binding site
439843010461	DNA adenine methylase; Provisional; Region: PRK10904
439843010462	cell division protein DamX; Validated; Region: PRK10905
439843010463	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266
439843010464	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
439843010465	active site
439843010466	dimer interface [polypeptide binding]; other site
439843010467	metal binding site [ion binding]; metal-binding site
439843010468	shikimate kinase; Reviewed; Region: aroK; PRK00131
439843010469	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
439843010470	ADP binding site [chemical binding]; other site
439843010471	magnesium binding site [ion binding]; other site
439843010472	putative shikimate binding site; other site
439843010473	Protein of unknown function (DUF2531); Region: DUF2531; pfam10748
439843010474	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
439843010475	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
439843010476	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
439843010477	Transglycosylase; Region: Transgly; pfam00912
439843010478	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
439843010479	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
439843010480	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
439843010481	ADP-ribose binding site [chemical binding]; other site
439843010482	dimer interface [polypeptide binding]; other site
439843010483	active site
439843010484	nudix motif; other site
439843010485	metal binding site [ion binding]; metal-binding site
439843010486	Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095
439843010487	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
439843010488	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439843010489	motif II; other site
439843010490	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
439843010491	RNA binding surface [nucleotide binding]; other site
439843010492	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
439843010493	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
439843010494	dimerization interface [polypeptide binding]; other site
439843010495	domain crossover interface; other site
439843010496	redox-dependent activation switch; other site
439843010497	Domain of unknown function (DUF4153); Region: DUF4153; pfam13687
439843010498	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
439843010499	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
439843010500	active site
439843010501	substrate-binding site [chemical binding]; other site
439843010502	metal-binding site [ion binding]
439843010503	ATP binding site [chemical binding]; other site
439843010504	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
439843010505	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
439843010506	dimerization interface [polypeptide binding]; other site
439843010507	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439843010508	dimer interface [polypeptide binding]; other site
439843010509	phosphorylation site [posttranslational modification]
439843010510	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439843010511	ATP binding site [chemical binding]; other site
439843010512	G-X-G motif; other site
439843010513	osmolarity response regulator; Provisional; Region: ompR; PRK09468
439843010514	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843010515	active site
439843010516	phosphorylation site [posttranslational modification]
439843010517	intermolecular recognition site; other site
439843010518	dimerization interface [polypeptide binding]; other site
439843010519	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
439843010520	DNA binding site [nucleotide binding]
439843010521	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
439843010522	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
439843010523	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
439843010524	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
439843010525	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
439843010526	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
439843010527	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
439843010528	RNA binding site [nucleotide binding]; other site
439843010529	ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555
439843010530	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
439843010531	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
439843010532	G1 box; other site
439843010533	GTP/Mg2+ binding site [chemical binding]; other site
439843010534	Switch I region; other site
439843010535	G2 box; other site
439843010536	G3 box; other site
439843010537	Switch II region; other site
439843010538	G4 box; other site
439843010539	G5 box; other site
439843010540	Nucleoside recognition; Region: Gate; pfam07670
439843010541	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
439843010542	Nucleoside recognition; Region: Gate; pfam07670
439843010543	ferrous iron transport protein FeoC; Provisional; Region: PRK15431
439843010544	hypothetical protein; Provisional; Region: PRK09956
439843010545	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
439843010546	carboxylesterase BioH; Provisional; Region: PRK10349
439843010547	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
439843010548	DNA utilization protein GntX; Provisional; Region: PRK11595
439843010549	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
439843010550	active site
439843010551	Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190
439843010552	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
439843010553	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
439843010554	high-affinity gluconate transporter; Provisional; Region: PRK14984
439843010555	gluconate transporter; Region: gntP; TIGR00791
439843010556	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
439843010557	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
439843010558	maltodextrin phosphorylase; Provisional; Region: PRK14985
439843010559	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
439843010560	homodimer interface [polypeptide binding]; other site
439843010561	active site pocket [active]
439843010562	transcriptional regulator MalT; Provisional; Region: PRK04841
439843010563	AAA ATPase domain; Region: AAA_16; pfam13191
439843010564	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
439843010565	DNA binding residues [nucleotide binding]
439843010566	dimerization interface [polypeptide binding]; other site
439843010567	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
439843010568	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
439843010569	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
439843010570	intramembrane serine protease GlpG; Provisional; Region: PRK10907
439843010571	Protein of unknown function (DUF3582); Region: DUF3582; pfam12122
439843010572	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
439843010573	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
439843010574	active site residue [active]
439843010575	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
439843010576	hypothetical protein; Provisional; Region: PRK09781; cl08057
439843010577	hypothetical protein; Provisional; Region: PRK09781; cl08057
439843010578	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
439843010579	glycogen phosphorylase; Provisional; Region: PRK14986
439843010580	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
439843010581	homodimer interface [polypeptide binding]; other site
439843010582	active site pocket [active]
439843010583	glycogen synthase; Provisional; Region: glgA; PRK00654
439843010584	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
439843010585	ADP-binding pocket [chemical binding]; other site
439843010586	homodimer interface [polypeptide binding]; other site
439843010587	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
439843010588	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
439843010589	ligand binding site; other site
439843010590	oligomer interface; other site
439843010591	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
439843010592	dimer interface [polypeptide binding]; other site
439843010593	N-terminal domain interface [polypeptide binding]; other site
439843010594	sulfate 1 binding site; other site
439843010595	glycogen debranching enzyme; Provisional; Region: PRK03705
439843010596	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
439843010597	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
439843010598	active site
439843010599	catalytic site [active]
439843010600	glycogen branching enzyme; Provisional; Region: PRK05402
439843010601	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
439843010602	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
439843010603	active site
439843010604	catalytic site [active]
439843010605	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
439843010606	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
439843010607	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
439843010608	low affinity gluconate transporter; Provisional; Region: PRK10472
439843010609	gluconate transporter; Region: gntP; TIGR00791
439843010610	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
439843010611	gluconate operon transcriptional regulator; Provisional; Region: PRK14987
439843010612	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
439843010613	DNA binding site [nucleotide binding]
439843010614	domain linker motif; other site
439843010615	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
439843010616	putative ligand binding site [chemical binding]; other site
439843010617	putative dimerization interface [polypeptide binding]; other site
439843010618	Pirin-related protein [General function prediction only]; Region: COG1741
439843010619	Pirin; Region: Pirin; pfam02678
439843010620	putative oxidoreductase; Provisional; Region: PRK10206
439843010621	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
439843010622	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
439843010623	putative acetyltransferase YhhY; Provisional; Region: PRK10140
439843010624	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
439843010625	Coenzyme A binding pocket [chemical binding]; other site
439843010626	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
439843010627	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
439843010628	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
439843010629	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
439843010630	substrate binding site [chemical binding]; other site
439843010631	dimer interface [polypeptide binding]; other site
439843010632	ATP binding site [chemical binding]; other site
439843010633	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
439843010634	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
439843010635	Protein of unknown function, DUF606; Region: DUF606; pfam04657
439843010636	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
439843010637	active site
439843010638	substrate binding pocket [chemical binding]; other site
439843010639	homodimer interaction site [polypeptide binding]; other site
439843010640	gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615
439843010641	gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066
439843010642	hypothetical protein; Provisional; Region: PRK10350
439843010643	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
439843010644	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
439843010645	putative active site [active]
439843010646	catalytic site [active]
439843010647	putative metal binding site [ion binding]; other site
439843010648	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
439843010649	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
439843010650	Walker A/P-loop; other site
439843010651	ATP binding site [chemical binding]; other site
439843010652	Q-loop/lid; other site
439843010653	ABC transporter signature motif; other site
439843010654	Walker B; other site
439843010655	D-loop; other site
439843010656	H-loop/switch region; other site
439843010657	TOBE domain; Region: TOBE_2; pfam08402
439843010658	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
439843010659	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843010660	dimer interface [polypeptide binding]; other site
439843010661	conserved gate region; other site
439843010662	ABC-ATPase subunit interface; other site
439843010663	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
439843010664	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843010665	putative PBP binding loops; other site
439843010666	dimer interface [polypeptide binding]; other site
439843010667	ABC-ATPase subunit interface; other site
439843010668	glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974
439843010669	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
439843010670	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614
439843010671	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
439843010672	Walker A/P-loop; other site
439843010673	ATP binding site [chemical binding]; other site
439843010674	Q-loop/lid; other site
439843010675	ABC transporter signature motif; other site
439843010676	Walker B; other site
439843010677	D-loop; other site
439843010678	H-loop/switch region; other site
439843010679	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
439843010680	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
439843010681	Walker A/P-loop; other site
439843010682	ATP binding site [chemical binding]; other site
439843010683	Q-loop/lid; other site
439843010684	ABC transporter signature motif; other site
439843010685	Walker B; other site
439843010686	D-loop; other site
439843010687	H-loop/switch region; other site
439843010688	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
439843010689	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
439843010690	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
439843010691	TM-ABC transporter signature motif; other site
439843010692	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
439843010693	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
439843010694	TM-ABC transporter signature motif; other site
439843010695	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
439843010696	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
439843010697	dimerization interface [polypeptide binding]; other site
439843010698	ligand binding site [chemical binding]; other site
439843010699	Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568
439843010700	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
439843010701	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
439843010702	dimerization interface [polypeptide binding]; other site
439843010703	ligand binding site [chemical binding]; other site
439843010704	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
439843010705	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
439843010706	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
439843010707	DNA binding residues [nucleotide binding]
439843010708	putative protein insertion permease FtsX; Region: ftsX; TIGR00439
439843010709	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
439843010710	cell division protein FtsE; Provisional; Region: PRK10908
439843010711	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439843010712	Walker A/P-loop; other site
439843010713	ATP binding site [chemical binding]; other site
439843010714	Q-loop/lid; other site
439843010715	ABC transporter signature motif; other site
439843010716	Walker B; other site
439843010717	D-loop; other site
439843010718	H-loop/switch region; other site
439843010719	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
439843010720	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
439843010721	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
439843010722	P loop; other site
439843010723	GTP binding site [chemical binding]; other site
439843010724	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
439843010725	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439843010726	S-adenosylmethionine binding site [chemical binding]; other site
439843010727	hypothetical protein; Provisional; Region: PRK10910
439843010728	Protein of unknown function (DUF2500); Region: DUF2500; pfam10694
439843010729	Predicted membrane protein [Function unknown]; Region: COG3714
439843010730	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
439843010731	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
439843010732	metal-binding site [ion binding]
439843010733	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
439843010734	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
439843010735	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
439843010736	dimer interface [polypeptide binding]; other site
439843010737	ligand binding site [chemical binding]; other site
439843010738	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
439843010739	dimerization interface [polypeptide binding]; other site
439843010740	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
439843010741	dimer interface [polypeptide binding]; other site
439843010742	putative CheW interface [polypeptide binding]; other site
439843010743	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
439843010744	CPxP  motif; other site
439843010745	hypothetical protein; Provisional; Region: PRK11212
439843010746	hypothetical protein; Provisional; Region: PRK11615
439843010747	major facilitator superfamily transporter; Provisional; Region: PRK05122
439843010748	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843010749	putative substrate translocation pore; other site
439843010750	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
439843010751	Domain of unknown function DUF20; Region: UPF0118; pfam01594
439843010752	holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351
439843010753	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
439843010754	nickel responsive regulator; Provisional; Region: PRK02967
439843010755	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
439843010756	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
439843010757	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
439843010758	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
439843010759	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
439843010760	Walker A/P-loop; other site
439843010761	ATP binding site [chemical binding]; other site
439843010762	Q-loop/lid; other site
439843010763	ABC transporter signature motif; other site
439843010764	Walker B; other site
439843010765	D-loop; other site
439843010766	H-loop/switch region; other site
439843010767	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
439843010768	Walker A/P-loop; other site
439843010769	ATP binding site [chemical binding]; other site
439843010770	Q-loop/lid; other site
439843010771	ABC transporter signature motif; other site
439843010772	Walker B; other site
439843010773	D-loop; other site
439843010774	H-loop/switch region; other site
439843010775	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
439843010776	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
439843010777	HlyD family secretion protein; Region: HlyD; pfam00529
439843010778	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
439843010779	HlyD family secretion protein; Region: HlyD_3; pfam13437
439843010780	Predicted flavoproteins [General function prediction only]; Region: COG2081
439843010781	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
439843010782	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
439843010783	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
439843010784	universal stress protein UspB; Provisional; Region: PRK04960
439843010785	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
439843010786	Ligand Binding Site [chemical binding]; other site
439843010787	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
439843010788	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843010789	putative substrate translocation pore; other site
439843010790	POT family; Region: PTR2; pfam00854
439843010791	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439843010792	S-adenosylmethionine binding site [chemical binding]; other site
439843010793	oligopeptidase A; Provisional; Region: PRK10911
439843010794	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
439843010795	active site
439843010796	Zn binding site [ion binding]; other site
439843010797	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
439843010798	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
439843010799	active site
439843010800	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
439843010801	glutathione reductase; Validated; Region: PRK06116
439843010802	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
439843010803	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
439843010804	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
439843010805	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
439843010806	active site
439843010807	homodimer interface [polypeptide binding]; other site
439843010808	homotetramer interface [polypeptide binding]; other site
439843010809	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
439843010810	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
439843010811	Fructoselysine kinase-like.  Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940
439843010812	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
439843010813	substrate binding site [chemical binding]; other site
439843010814	ATP binding site [chemical binding]; other site
439843010815	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
439843010816	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
439843010817	putative active site [active]
439843010818	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
439843010819	dimer interface [polypeptide binding]; other site
439843010820	active site
439843010821	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
439843010822	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439843010823	DNA-binding site [nucleotide binding]; DNA binding site
439843010824	UTRA domain; Region: UTRA; pfam07702
439843010825	trehalase; Provisional; Region: treF; PRK13270
439843010826	Trehalase; Region: Trehalase; pfam01204
439843010827	Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772
439843010828	catalytic residue [active]
439843010829	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
439843010830	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
439843010831	active site
439843010832	phosphorylation site [posttranslational modification]
439843010833	dimerization interface [polypeptide binding]; other site
439843010834	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
439843010835	DNA binding residues [nucleotide binding]
439843010836	dimerization interface [polypeptide binding]; other site
439843010837	Transcriptional regulator [Transcription]; Region: LysR; COG0583
439843010838	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843010839	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
439843010840	putative effector binding pocket; other site
439843010841	putative dimerization interface [polypeptide binding]; other site
439843010842	inner membrane protein YhjD; Region: TIGR00766
439843010843	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843010844	metabolite-proton symporter; Region: 2A0106; TIGR00883
439843010845	putative substrate translocation pore; other site
439843010846	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
439843010847	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
439843010848	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
439843010849	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
439843010850	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
439843010851	substrate binding site [chemical binding]; other site
439843010852	ATP binding site [chemical binding]; other site
439843010853	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
439843010854	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
439843010855	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
439843010856	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
439843010857	putative diguanylate cyclase; Provisional; Region: PRK13561
439843010858	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
439843010859	metal binding site [ion binding]; metal-binding site
439843010860	active site
439843010861	I-site; other site
439843010862	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
439843010863	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
439843010864	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
439843010865	TPR motif; other site
439843010866	binding surface
439843010867	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
439843010868	binding surface
439843010869	TPR motif; other site
439843010870	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
439843010871	endo-1,4-D-glucanase; Provisional; Region: PRK11097
439843010872	cellulose synthase regulator protein; Provisional; Region: PRK11114
439843010873	cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498
439843010874	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
439843010875	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
439843010876	DXD motif; other site
439843010877	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
439843010878	PilZ domain; Region: PilZ; pfam07238
439843010879	cell division protein; Provisional; Region: PRK10037
439843010880	Protein of unknown function (DUF2629); Region: DUF2629; pfam10945
439843010881	cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045
439843010882	Protein of unknown function (DUF2819); Region: DUF2819; pfam10995
439843010883	Protein of unknown function (DUF2636); Region: DUF2636; pfam11120
439843010884	cellulose synthase operon protein YhjU; Region: cellulose_yhjU; TIGR03368
439843010885	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
439843010886	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
439843010887	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
439843010888	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
439843010889	Walker A/P-loop; other site
439843010890	ATP binding site [chemical binding]; other site
439843010891	Q-loop/lid; other site
439843010892	ABC transporter signature motif; other site
439843010893	Walker B; other site
439843010894	D-loop; other site
439843010895	H-loop/switch region; other site
439843010896	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
439843010897	dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022
439843010898	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
439843010899	Walker A/P-loop; other site
439843010900	ATP binding site [chemical binding]; other site
439843010901	Q-loop/lid; other site
439843010902	ABC transporter signature motif; other site
439843010903	Walker B; other site
439843010904	D-loop; other site
439843010905	H-loop/switch region; other site
439843010906	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
439843010907	dipeptide transporter; Provisional; Region: PRK10913
439843010908	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
439843010909	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843010910	dimer interface [polypeptide binding]; other site
439843010911	conserved gate region; other site
439843010912	putative PBP binding loops; other site
439843010913	ABC-ATPase subunit interface; other site
439843010914	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
439843010915	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843010916	dimer interface [polypeptide binding]; other site
439843010917	conserved gate region; other site
439843010918	putative PBP binding loops; other site
439843010919	ABC-ATPase subunit interface; other site
439843010920	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
439843010921	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
439843010922	peptide binding site [polypeptide binding]; other site
439843010923	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
439843010924	Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269
439843010925	Transcriptional regulators [Transcription]; Region: PurR; COG1609
439843010926	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
439843010927	DNA binding site [nucleotide binding]
439843010928	domain linker motif; other site
439843010929	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_8; cd06287
439843010930	putative dimerization interface [polypeptide binding]; other site
439843010931	putative ligand binding site [chemical binding]; other site
439843010932	phosphoethanolamine transferase; Provisional; Region: PRK11560
439843010933	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
439843010934	Sulfatase; Region: Sulfatase; pfam00884
439843010935	Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571
439843010936	3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353
439843010937	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
439843010938	Coenzyme A binding pocket [chemical binding]; other site
439843010939	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
439843010940	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
439843010941	molybdopterin cofactor binding site [chemical binding]; other site
439843010942	substrate binding site [chemical binding]; other site
439843010943	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
439843010944	molybdopterin cofactor binding site; other site
439843010945	putative outer membrane lipoprotein; Provisional; Region: PRK10510
439843010946	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
439843010947	ligand binding site [chemical binding]; other site
439843010948	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
439843010949	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
439843010950	dimerization interface [polypeptide binding]; other site
439843010951	ligand binding site [chemical binding]; other site
439843010952	NADP binding site [chemical binding]; other site
439843010953	catalytic site [active]
439843010954	Protein of unknown function (DUF3053); Region: DUF3053; pfam11254
439843010955	Predicted transcriptional regulator [Transcription]; Region: COG2944
439843010956	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
439843010957	salt bridge; other site
439843010958	non-specific DNA binding site [nucleotide binding]; other site
439843010959	sequence-specific DNA binding site [nucleotide binding]; other site
439843010960	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
439843010961	DNA-binding site [nucleotide binding]; DNA binding site
439843010962	RNA-binding motif; other site
439843010963	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
439843010964	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
439843010965	DALR anticodon binding domain; Region: DALR_1; pfam05746
439843010966	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
439843010967	dimer interface [polypeptide binding]; other site
439843010968	motif 1; other site
439843010969	active site
439843010970	motif 2; other site
439843010971	motif 3; other site
439843010972	YsaB-like lipoprotein; Region: YsaB; pfam13983
439843010973	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
439843010974	Acyltransferase family; Region: Acyl_transf_3; pfam01757
439843010975	Predicted membrane protein [Function unknown]; Region: COG4682
439843010976	yiaA/B two helix domain; Region: YiaAB; pfam05360
439843010977	yiaA/B two helix domain; Region: YiaAB; pfam05360
439843010978	xylose isomerase; Provisional; Region: PRK05474
439843010979	xylose isomerase; Region: xylose_isom_A; TIGR02630
439843010980	Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543
439843010981	putative dimerization interface [polypeptide binding]; other site
439843010982	Transcriptional regulators [Transcription]; Region: PurR; COG1609
439843010983	putative ligand binding site [chemical binding]; other site
439843010984	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439843010985	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
439843010986	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439843010987	hypothetical protein; Provisional; Region: PRK10356
439843010988	Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992
439843010989	alpha-amylase; Reviewed; Region: malS; PRK09505
439843010990	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
439843010991	active site
439843010992	catalytic site [active]
439843010993	valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440
439843010994	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
439843010995	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843010996	homodimer interface [polypeptide binding]; other site
439843010997	catalytic residue [active]
439843010998	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
439843010999	Transcriptional regulator [Transcription]; Region: IclR; COG1414
439843011000	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
439843011001	Bacterial transcriptional regulator; Region: IclR; pfam01614
439843011002	2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260
439843011003	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
439843011004	2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877
439843011005	L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060
439843011006	DctM-like transporters; Region: DctM; pfam06808
439843011007	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
439843011008	tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787
439843011009	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
439843011010	L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802
439843011011	putative N- and C-terminal domain interface [polypeptide binding]; other site
439843011012	putative active site [active]
439843011013	MgATP binding site [chemical binding]; other site
439843011014	catalytic site [active]
439843011015	metal binding site [ion binding]; metal-binding site
439843011016	putative xylulose binding site [chemical binding]; other site
439843011017	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
439843011018	active site
439843011019	dimer interface [polypeptide binding]; other site
439843011020	magnesium binding site [ion binding]; other site
439843011021	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
439843011022	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
439843011023	AP (apurinic/apyrimidinic) site pocket; other site
439843011024	DNA interaction; other site
439843011025	Metal-binding active site; metal-binding site
439843011026	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
439843011027	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
439843011028	intersubunit interface [polypeptide binding]; other site
439843011029	active site
439843011030	Zn2+ binding site [ion binding]; other site
439843011031	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
439843011032	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
439843011033	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439843011034	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
439843011035	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
439843011036	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
439843011037	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
439843011038	NAD(P) binding site [chemical binding]; other site
439843011039	catalytic residues [active]
439843011040	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
439843011041	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
439843011042	nucleotide binding site [chemical binding]; other site
439843011043	putative alcohol dehydrogenase; Provisional; Region: PRK09860
439843011044	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
439843011045	dimer interface [polypeptide binding]; other site
439843011046	active site
439843011047	metal binding site [ion binding]; metal-binding site
439843011048	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
439843011049	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
439843011050	G1 box; other site
439843011051	putative GEF interaction site [polypeptide binding]; other site
439843011052	GTP/Mg2+ binding site [chemical binding]; other site
439843011053	Switch I region; other site
439843011054	G2 box; other site
439843011055	G3 box; other site
439843011056	Switch II region; other site
439843011057	G4 box; other site
439843011058	G5 box; other site
439843011059	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
439843011060	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
439843011061	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
439843011062	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
439843011063	selenocysteine synthase; Provisional; Region: PRK04311
439843011064	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
439843011065	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
439843011066	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
439843011067	catalytic residue [active]
439843011068	putative glutathione S-transferase; Provisional; Region: PRK10357
439843011069	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
439843011070	putative C-terminal domain interface [polypeptide binding]; other site
439843011071	putative GSH binding site (G-site) [chemical binding]; other site
439843011072	putative dimer interface [polypeptide binding]; other site
439843011073	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
439843011074	dimer interface [polypeptide binding]; other site
439843011075	N-terminal domain interface [polypeptide binding]; other site
439843011076	putative substrate binding pocket (H-site) [chemical binding]; other site
439843011077	PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083
439843011078	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
439843011079	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
439843011080	active site
439843011081	P-loop; other site
439843011082	phosphorylation site [posttranslational modification]
439843011083	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
439843011084	active site
439843011085	phosphorylation site [posttranslational modification]
439843011086	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
439843011087	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
439843011088	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
439843011089	Transcriptional regulator [Transcription]; Region: MtlR; COG3722
439843011090	mannitol repressor protein; Provisional; Region: mtlR; PRK11001
439843011091	hypothetical protein; Provisional; Region: PRK11020
439843011092	Protein of unknown function (DUF3251); Region: DUF3251; cl08186
439843011093	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
439843011094	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
439843011095	trimer interface [polypeptide binding]; other site
439843011096	Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295
439843011097	Haemagglutinin; Region: HIM; pfam05662
439843011098	Haemagglutinin; Region: HIM; pfam05662
439843011099	YadA-like C-terminal region; Region: YadA; pfam03895
439843011100	L-lactate permease; Provisional; Region: PRK10420
439843011101	glycolate transporter; Provisional; Region: PRK09695
439843011102	DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421
439843011103	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439843011104	DNA-binding site [nucleotide binding]; DNA binding site
439843011105	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
439843011106	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
439843011107	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
439843011108	active site
439843011109	substrate binding site [chemical binding]; other site
439843011110	FMN binding site [chemical binding]; other site
439843011111	putative catalytic residues [active]
439843011112	putative rRNA methylase; Provisional; Region: PRK10358
439843011113	serine acetyltransferase; Provisional; Region: cysE; PRK11132
439843011114	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
439843011115	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
439843011116	trimer interface [polypeptide binding]; other site
439843011117	active site
439843011118	substrate binding site [chemical binding]; other site
439843011119	CoA binding site [chemical binding]; other site
439843011120	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
439843011121	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
439843011122	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
439843011123	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
439843011124	SecA binding site; other site
439843011125	Preprotein binding site; other site
439843011126	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
439843011127	GSH binding site [chemical binding]; other site
439843011128	catalytic residues [active]
439843011129	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
439843011130	active site residue [active]
439843011131	phosphoglyceromutase; Provisional; Region: PRK05434
439843011132	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307
439843011133	AmiB activator; Provisional; Region: PRK11637
439843011134	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
439843011135	Peptidase family M23; Region: Peptidase_M23; pfam01551
439843011136	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
439843011137	NodB motif; other site
439843011138	putative active site [active]
439843011139	putative catalytic site [active]
439843011140	Zn binding site [ion binding]; other site
439843011141	putative glycosyl transferase; Provisional; Region: PRK10073
439843011142	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
439843011143	active site
439843011144	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
439843011145	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
439843011146	NAD(P) binding site [chemical binding]; other site
439843011147	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
439843011148	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
439843011149	substrate-cofactor binding pocket; other site
439843011150	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843011151	catalytic residue [active]
439843011152	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
439843011153	ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150
439843011154	NADP binding site [chemical binding]; other site
439843011155	homopentamer interface [polypeptide binding]; other site
439843011156	substrate binding site [chemical binding]; other site
439843011157	active site
439843011158	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
439843011159	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
439843011160	putative active site [active]
439843011161	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
439843011162	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
439843011163	putative active site [active]
439843011164	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
439843011165	O-antigen ligase RfaL; Provisional; Region: PRK15487
439843011166	lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484
439843011167	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
439843011168	lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822
439843011169	Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176
439843011170	Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442
439843011171	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
439843011172	Ligand binding site; other site
439843011173	metal-binding site
439843011174	Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437
439843011175	lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171
439843011176	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
439843011177	Ligand binding site; other site
439843011178	metal-binding site
439843011179	Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437
439843011180	UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922
439843011181	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
439843011182	putative ADP-binding pocket [chemical binding]; other site
439843011183	Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922
439843011184	lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123
439843011185	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
439843011186	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
439843011187	lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422
439843011188	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
439843011189	putative active site [active]
439843011190	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
439843011191	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
439843011192	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
439843011193	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
439843011194	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
439843011195	active site
439843011196	(T/H)XGH motif; other site
439843011197	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
439843011198	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
439843011199	DNA binding site [nucleotide binding]
439843011200	catalytic residue [active]
439843011201	H2TH interface [polypeptide binding]; other site
439843011202	putative catalytic residues [active]
439843011203	turnover-facilitating residue; other site
439843011204	intercalation triad [nucleotide binding]; other site
439843011205	8OG recognition residue [nucleotide binding]; other site
439843011206	putative reading head residues; other site
439843011207	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
439843011208	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
439843011209	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
439843011210	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
439843011211	hypothetical protein; Reviewed; Region: PRK00024
439843011212	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
439843011213	MPN+ (JAMM) motif; other site
439843011214	Zinc-binding site [ion binding]; other site
439843011215	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
439843011216	Flavoprotein; Region: Flavoprotein; pfam02441
439843011217	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
439843011218	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
439843011219	trimer interface [polypeptide binding]; other site
439843011220	active site
439843011221	division inhibitor protein; Provisional; Region: slmA; PRK09480
439843011222	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
439843011223	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
439843011224	active site
439843011225	ribonuclease PH; Reviewed; Region: rph; PRK00173
439843011226	Ribonuclease PH; Region: RNase_PH_bact; cd11362
439843011227	hexamer interface [polypeptide binding]; other site
439843011228	active site
439843011229	hypothetical protein; Provisional; Region: PRK11820
439843011230	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
439843011231	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
439843011232	integrase; Provisional; Region: PRK09692
439843011233	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
439843011234	active site
439843011235	Int/Topo IB signature motif; other site
439843011236	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
439843011237	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
439843011238	Transcriptional regulator [Transcription]; Region: LysR; COG0583
439843011239	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843011240	dimerization interface [polypeptide binding]; other site
439843011241	LysR substrate binding domain; Region: LysR_substrate; pfam03466
439843011242	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
439843011243	Predicted membrane protein [Function unknown]; Region: COG2860
439843011244	UPF0126 domain; Region: UPF0126; pfam03458
439843011245	UPF0126 domain; Region: UPF0126; pfam03458
439843011246	NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097
439843011247	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
439843011248	nucleotide binding pocket [chemical binding]; other site
439843011249	K-X-D-G motif; other site
439843011250	catalytic site [active]
439843011251	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
439843011252	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
439843011253	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
439843011254	catalytic site [active]
439843011255	G-X2-G-X-G-K; other site
439843011256	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
439843011257	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
439843011258	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
439843011259	Zn2+ binding site [ion binding]; other site
439843011260	Mg2+ binding site [ion binding]; other site
439843011261	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
439843011262	synthetase active site [active]
439843011263	NTP binding site [chemical binding]; other site
439843011264	metal binding site [ion binding]; metal-binding site
439843011265	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
439843011266	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
439843011267	tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081
439843011268	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
439843011269	SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
439843011270	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
439843011271	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
439843011272	generic binding surface II; other site
439843011273	ssDNA binding site; other site
439843011274	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
439843011275	ATP binding site [chemical binding]; other site
439843011276	putative Mg++ binding site [ion binding]; other site
439843011277	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
439843011278	nucleotide binding region [chemical binding]; other site
439843011279	ATP-binding site [chemical binding]; other site
439843011280	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
439843011281	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
439843011282	AsmA family; Region: AsmA; pfam05170
439843011283	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
439843011284	putative alpha-glucosidase; Provisional; Region: PRK10658
439843011285	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
439843011286	YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593
439843011287	active site
439843011288	homotrimer interface [polypeptide binding]; other site
439843011289	catalytic site [active]
439843011290	homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site
439843011291	putative transporter; Provisional; Region: PRK11462
439843011292	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
439843011293	Transposase; Region: HTH_Tnp_1; cl17663
439843011294	autotransport protein MisL; Provisional; Region: PRK15313
439843011295	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
439843011296	Autotransporter beta-domain; Region: Autotransporter; pfam03797
439843011297	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
439843011298	DNA binding site [nucleotide binding]
439843011299	Isochorismatase family; Region: Isochorismatase; pfam00857
439843011300	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
439843011301	catalytic triad [active]
439843011302	dimer interface [polypeptide binding]; other site
439843011303	conserved cis-peptide bond; other site
439843011304	magnesium-transporting ATPase; Provisional; Region: PRK15122
439843011305	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
439843011306	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
439843011307	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
439843011308	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439843011309	motif II; other site
439843011310	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
439843011311	magnesium transport protein MgtC; Provisional; Region: PRK15385
439843011312	MgtC family; Region: MgtC; pfam02308
439843011313	EamA-like transporter family; Region: EamA; pfam00892
439843011314	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
439843011315	EamA-like transporter family; Region: EamA; pfam00892
439843011316	hypothetical protein; Provisional; Region: PRK09956
439843011317	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
439843011318	Protein of unknown function (DUF1341); Region: DUF1341; cl06211
439843011319	uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437
439843011320	L-seryl-tRNA selenium transferase; Region: SelA; pfam03841
439843011321	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
439843011322	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
439843011323	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
439843011324	active site
439843011325	phosphorylation site [posttranslational modification]
439843011326	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
439843011327	active pocket/dimerization site; other site
439843011328	active site
439843011329	phosphorylation site [posttranslational modification]
439843011330	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
439843011331	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439843011332	Walker A motif; other site
439843011333	ATP binding site [chemical binding]; other site
439843011334	Walker B motif; other site
439843011335	arginine finger; other site
439843011336	Transcriptional antiterminator [Transcription]; Region: COG3933
439843011337	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
439843011338	active site
439843011339	active pocket/dimerization site; other site
439843011340	phosphorylation site [posttranslational modification]
439843011341	PRD domain; Region: PRD; pfam00874
439843011342	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
439843011343	beta-galactosidase; Region: BGL; TIGR03356
439843011344	ribonucleoside transporter; Reviewed; Region: nepI; PRK10213
439843011345	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843011346	putative substrate translocation pore; other site
439843011347	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737
439843011348	Predicted transcriptional regulator [Transcription]; Region: COG2944
439843011349	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
439843011350	non-specific DNA binding site [nucleotide binding]; other site
439843011351	salt bridge; other site
439843011352	sequence-specific DNA binding site [nucleotide binding]; other site
439843011353	GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440
439843011354	GIY-YIG motif/motif A; other site
439843011355	putative active site [active]
439843011356	putative metal binding site [ion binding]; other site
439843011357	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
439843011358	dimerization domain swap beta strand [polypeptide binding]; other site
439843011359	regulatory protein interface [polypeptide binding]; other site
439843011360	active site
439843011361	regulatory phosphorylation site [posttranslational modification]; other site
439843011362	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
439843011363	intersubunit interface [polypeptide binding]; other site
439843011364	active site
439843011365	zinc binding site [ion binding]; other site
439843011366	Na+ binding site [ion binding]; other site
439843011367	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
439843011368	uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774
439843011369	putative N- and C-terminal domain interface [polypeptide binding]; other site
439843011370	putative active site [active]
439843011371	putative MgATP binding site [chemical binding]; other site
439843011372	catalytic site [active]
439843011373	metal binding site [ion binding]; metal-binding site
439843011374	putative carbohydrate binding site [chemical binding]; other site
439843011375	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
439843011376	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
439843011377	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
439843011378	active site
439843011379	P-loop; other site
439843011380	phosphorylation site [posttranslational modification]
439843011381	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
439843011382	active site
439843011383	phosphorylation site [posttranslational modification]
439843011384	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
439843011385	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439843011386	DNA-binding site [nucleotide binding]; DNA binding site
439843011387	UTRA domain; Region: UTRA; pfam07702
439843011388	Protein of unknown function (DUF1198); Region: DUF1198; pfam06711
439843011389	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
439843011390	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843011391	putative substrate translocation pore; other site
439843011392	regulatory protein UhpC; Provisional; Region: PRK11663
439843011393	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843011394	putative substrate translocation pore; other site
439843011395	sensory histidine kinase UhpB; Provisional; Region: PRK11644
439843011396	MASE1; Region: MASE1; pfam05231
439843011397	Histidine kinase; Region: HisKA_3; pfam07730
439843011398	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
439843011399	DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360
439843011400	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843011401	active site
439843011402	phosphorylation site [posttranslational modification]
439843011403	intermolecular recognition site; other site
439843011404	dimerization interface [polypeptide binding]; other site
439843011405	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
439843011406	DNA binding residues [nucleotide binding]
439843011407	dimerization interface [polypeptide binding]; other site
439843011408	deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269
439843011409	active site
439843011410	catalytic residues [active]
439843011411	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
439843011412	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843011413	putative substrate translocation pore; other site
439843011414	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
439843011415	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
439843011416	substrate binding site [chemical binding]; other site
439843011417	dimer interface [polypeptide binding]; other site
439843011418	ATP binding site [chemical binding]; other site
439843011419	DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681
439843011420	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
439843011421	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
439843011422	Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440
439843011423	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
439843011424	putative valine binding site [chemical binding]; other site
439843011425	dimer interface [polypeptide binding]; other site
439843011426	acetolactate synthase catalytic subunit; Validated; Region: PRK08155
439843011427	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
439843011428	PYR/PP interface [polypeptide binding]; other site
439843011429	dimer interface [polypeptide binding]; other site
439843011430	TPP binding site [chemical binding]; other site
439843011431	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
439843011432	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
439843011433	TPP-binding site [chemical binding]; other site
439843011434	dimer interface [polypeptide binding]; other site
439843011435	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
439843011436	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
439843011437	multidrug resistance protein D; Provisional; Region: emrD; PRK11652
439843011438	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843011439	putative substrate translocation pore; other site
439843011440	DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086
439843011441	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843011442	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
439843011443	dimerization interface [polypeptide binding]; other site
439843011444	substrate binding pocket [chemical binding]; other site
439843011445	permease DsdX; Provisional; Region: PRK09921
439843011446	gluconate transporter; Region: gntP; TIGR00791
439843011447	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
439843011448	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
439843011449	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
439843011450	catalytic residue [active]
439843011451	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
439843011452	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
439843011453	Domain of unknown function (DUF202); Region: DUF202; pfam02656
439843011454	Predicted membrane protein [Function unknown]; Region: COG2149
439843011455	putative transporter; Validated; Region: PRK03818
439843011456	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
439843011457	TrkA-C domain; Region: TrkA_C; pfam02080
439843011458	TrkA-C domain; Region: TrkA_C; pfam02080
439843011459	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
439843011460	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
439843011461	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
439843011462	putative dimer interface [polypeptide binding]; other site
439843011463	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
439843011464	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
439843011465	putative dimer interface [polypeptide binding]; other site
439843011466	hypothetical protein; Provisional; Region: PRK11616
439843011467	Protein of unknown function (DUF3748); Region: DUF3748; pfam12566
439843011468	Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088
439843011469	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
439843011470	thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412
439843011471	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
439843011472	catalytic residues [active]
439843011473	central insert; other site
439843011474	c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353
439843011475	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150
439843011476	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
439843011477	heme exporter protein CcmC; Region: ccmC; TIGR01191
439843011478	heme exporter protein CcmB; Region: ccmB; TIGR01190
439843011479	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
439843011480	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439843011481	Walker A/P-loop; other site
439843011482	ATP binding site [chemical binding]; other site
439843011483	Q-loop/lid; other site
439843011484	ABC transporter signature motif; other site
439843011485	Walker B; other site
439843011486	D-loop; other site
439843011487	H-loop/switch region; other site
439843011488	Haem-binding domain; Region: Haem_bd; pfam14376
439843011489	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
439843011490	chaperone protein TorD; Validated; Region: torD; PRK04976
439843011491	trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102
439843011492	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
439843011493	molybdopterin cofactor binding site [chemical binding]; other site
439843011494	substrate binding site [chemical binding]; other site
439843011495	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
439843011496	molybdopterin cofactor binding site; other site
439843011497	trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032
439843011498	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
439843011499	DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766
439843011500	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843011501	active site
439843011502	phosphorylation site [posttranslational modification]
439843011503	intermolecular recognition site; other site
439843011504	dimerization interface [polypeptide binding]; other site
439843011505	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
439843011506	DNA binding site [nucleotide binding]
439843011507	TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936
439843011508	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
439843011509	hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466
439843011510	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439843011511	dimer interface [polypeptide binding]; other site
439843011512	phosphorylation site [posttranslational modification]
439843011513	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439843011514	ATP binding site [chemical binding]; other site
439843011515	Mg2+ binding site [ion binding]; other site
439843011516	G-X-G motif; other site
439843011517	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843011518	active site
439843011519	phosphorylation site [posttranslational modification]
439843011520	intermolecular recognition site; other site
439843011521	dimerization interface [polypeptide binding]; other site
439843011522	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
439843011523	putative binding surface; other site
439843011524	active site
439843011525	Protein of unknown function (DUF4056); Region: DUF4056; pfam13265
439843011526	Surface antigen; Region: Bac_surface_Ag; pfam01103
439843011527	sugar phosphate phosphatase; Provisional; Region: PRK10513
439843011528	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439843011529	active site
439843011530	motif I; other site
439843011531	motif II; other site
439843011532	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439843011533	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843011534	D-galactonate transporter; Region: 2A0114; TIGR00893
439843011535	putative substrate translocation pore; other site
439843011536	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843011537	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
439843011538	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
439843011539	active site pocket [active]
439843011540	Transcriptional regulator [Transcription]; Region: LysR; COG0583
439843011541	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843011542	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
439843011543	putative dimerization interface [polypeptide binding]; other site
439843011544	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
439843011545	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439843011546	Mg2+ binding site [ion binding]; other site
439843011547	G-X-G motif; other site
439843011548	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
439843011549	anchoring element; other site
439843011550	dimer interface [polypeptide binding]; other site
439843011551	ATP binding site [chemical binding]; other site
439843011552	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
439843011553	active site
439843011554	putative metal-binding site [ion binding]; other site
439843011555	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
439843011556	recF protein; Region: recf; TIGR00611
439843011557	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439843011558	Walker A/P-loop; other site
439843011559	ATP binding site [chemical binding]; other site
439843011560	Q-loop/lid; other site
439843011561	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439843011562	ABC transporter signature motif; other site
439843011563	Walker B; other site
439843011564	D-loop; other site
439843011565	H-loop/switch region; other site
439843011566	DNA polymerase III subunit beta; Validated; Region: PRK05643
439843011567	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
439843011568	putative DNA binding surface [nucleotide binding]; other site
439843011569	dimer interface [polypeptide binding]; other site
439843011570	beta-clamp/clamp loader binding surface; other site
439843011571	beta-clamp/translesion DNA polymerase binding surface; other site
439843011572	DnaA N-terminal domain; Region: DnaA_N; pfam11638
439843011573	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
439843011574	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439843011575	Walker A motif; other site
439843011576	ATP binding site [chemical binding]; other site
439843011577	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
439843011578	Walker B motif; other site
439843011579	arginine finger; other site
439843011580	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
439843011581	DnaA box-binding interface [nucleotide binding]; other site
439843011582	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
439843011583	ribonuclease P; Reviewed; Region: rnpA; PRK01732
439843011584	membrane protein insertase; Provisional; Region: PRK01318
439843011585	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
439843011586	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
439843011587	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
439843011588	trmE is a tRNA modification GTPase; Region: trmE; cd04164
439843011589	G1 box; other site
439843011590	GTP/Mg2+ binding site [chemical binding]; other site
439843011591	Switch I region; other site
439843011592	G2 box; other site
439843011593	Switch II region; other site
439843011594	G3 box; other site
439843011595	G4 box; other site
439843011596	G5 box; other site
439843011597	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
439843011598	multidrug efflux system protein MdtL; Provisional; Region: PRK10473
439843011599	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843011600	putative substrate translocation pore; other site
439843011601	DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216
439843011602	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843011603	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
439843011604	substrate binding pocket [chemical binding]; other site
439843011605	dimerization interface [polypeptide binding]; other site
439843011606	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
439843011607	Predicted flavoprotein [General function prediction only]; Region: COG0431
439843011608	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
439843011609	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
439843011610	6-phosphogluconate phosphatase; Provisional; Region: PRK10563
439843011611	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439843011612	active site
439843011613	motif I; other site
439843011614	motif II; other site
439843011615	transcriptional regulator PhoU; Provisional; Region: PRK11115
439843011616	PhoU domain; Region: PhoU; pfam01895
439843011617	PhoU domain; Region: PhoU; pfam01895
439843011618	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
439843011619	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
439843011620	Walker A/P-loop; other site
439843011621	ATP binding site [chemical binding]; other site
439843011622	Q-loop/lid; other site
439843011623	ABC transporter signature motif; other site
439843011624	Walker B; other site
439843011625	D-loop; other site
439843011626	H-loop/switch region; other site
439843011627	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
439843011628	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843011629	dimer interface [polypeptide binding]; other site
439843011630	conserved gate region; other site
439843011631	putative PBP binding loops; other site
439843011632	ABC-ATPase subunit interface; other site
439843011633	phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275
439843011634	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843011635	dimer interface [polypeptide binding]; other site
439843011636	conserved gate region; other site
439843011637	putative PBP binding loops; other site
439843011638	ABC-ATPase subunit interface; other site
439843011639	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
439843011640	substrate binding pocket [chemical binding]; other site
439843011641	membrane-bound complex binding site; other site
439843011642	hinge residues; other site
439843011643	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
439843011644	active site
439843011645	P-loop; other site
439843011646	phosphorylation site [posttranslational modification]
439843011647	PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427
439843011648	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
439843011649	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
439843011650	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
439843011651	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
439843011652	shikimate binding site; other site
439843011653	NAD(P) binding site [chemical binding]; other site
439843011654	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
439843011655	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
439843011656	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
439843011657	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
439843011658	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
439843011659	glutaminase active site [active]
439843011660	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
439843011661	dimer interface [polypeptide binding]; other site
439843011662	active site
439843011663	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
439843011664	dimer interface [polypeptide binding]; other site
439843011665	active site
439843011666	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451
439843011667	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
439843011668	Substrate binding site; other site
439843011669	Mg++ binding site; other site
439843011670	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
439843011671	active site
439843011672	substrate binding site [chemical binding]; other site
439843011673	CoA binding site [chemical binding]; other site
439843011674	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
439843011675	Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027
439843011676	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
439843011677	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
439843011678	gamma subunit interface [polypeptide binding]; other site
439843011679	epsilon subunit interface [polypeptide binding]; other site
439843011680	LBP interface [polypeptide binding]; other site
439843011681	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
439843011682	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
439843011683	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
439843011684	alpha subunit interaction interface [polypeptide binding]; other site
439843011685	Walker A motif; other site
439843011686	ATP binding site [chemical binding]; other site
439843011687	Walker B motif; other site
439843011688	inhibitor binding site; inhibition site
439843011689	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
439843011690	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
439843011691	core domain interface [polypeptide binding]; other site
439843011692	delta subunit interface [polypeptide binding]; other site
439843011693	epsilon subunit interface [polypeptide binding]; other site
439843011694	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
439843011695	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
439843011696	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
439843011697	beta subunit interaction interface [polypeptide binding]; other site
439843011698	Walker A motif; other site
439843011699	ATP binding site [chemical binding]; other site
439843011700	Walker B motif; other site
439843011701	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
439843011702	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
439843011703	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
439843011704	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
439843011705	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
439843011706	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
439843011707	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
439843011708	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
439843011709	ATP synthase I chain; Region: ATP_synt_I; cl09170
439843011710	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
439843011711	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439843011712	S-adenosylmethionine binding site [chemical binding]; other site
439843011713	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
439843011714	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
439843011715	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
439843011716	FMN-binding protein MioC; Provisional; Region: PRK09004
439843011717	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
439843011718	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
439843011719	putative DNA binding site [nucleotide binding]; other site
439843011720	putative Zn2+ binding site [ion binding]; other site
439843011721	AsnC family; Region: AsnC_trans_reg; pfam01037
439843011722	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
439843011723	dimer interface [polypeptide binding]; other site
439843011724	active site
439843011725	hypothetical protein; Provisional; Region: yieM; PRK10997
439843011726	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
439843011727	metal ion-dependent adhesion site (MIDAS); other site
439843011728	regulatory ATPase RavA; Provisional; Region: PRK13531
439843011729	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439843011730	Walker A motif; other site
439843011731	ATP binding site [chemical binding]; other site
439843011732	Walker B motif; other site
439843011733	arginine finger; other site
439843011734	Protein of unknown function (DUF3763); Region: DUF3763; pfam12592
439843011735	potassium transport protein Kup; Provisional; Region: trkD; PRK10745
439843011736	potassium uptake protein; Region: kup; TIGR00794
439843011737	D-ribose pyranase; Provisional; Region: PRK11797
439843011738	D-ribose transporter ATP binding protein; Provisional; Region: PRK10762
439843011739	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
439843011740	Walker A/P-loop; other site
439843011741	ATP binding site [chemical binding]; other site
439843011742	Q-loop/lid; other site
439843011743	ABC transporter signature motif; other site
439843011744	Walker B; other site
439843011745	D-loop; other site
439843011746	H-loop/switch region; other site
439843011747	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
439843011748	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
439843011749	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
439843011750	TM-ABC transporter signature motif; other site
439843011751	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
439843011752	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
439843011753	ligand binding site [chemical binding]; other site
439843011754	dimerization interface [polypeptide binding]; other site
439843011755	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
439843011756	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
439843011757	substrate binding site [chemical binding]; other site
439843011758	dimer interface [polypeptide binding]; other site
439843011759	ATP binding site [chemical binding]; other site
439843011760	transcriptional repressor RbsR; Provisional; Region: PRK10423
439843011761	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
439843011762	DNA binding site [nucleotide binding]
439843011763	domain linker motif; other site
439843011764	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
439843011765	dimerization interface [polypeptide binding]; other site
439843011766	ligand binding site [chemical binding]; other site
439843011767	putative transporter; Provisional; Region: PRK10504
439843011768	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843011769	putative substrate translocation pore; other site
439843011770	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843011771	Transcriptional regulators [Transcription]; Region: FadR; COG2186
439843011772	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439843011773	DNA-binding site [nucleotide binding]; DNA binding site
439843011774	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
439843011775	transcriptional regulator HdfR; Provisional; Region: PRK03601
439843011776	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843011777	LysR substrate binding domain; Region: LysR_substrate; pfam03466
439843011778	dimerization interface [polypeptide binding]; other site
439843011779	hypothetical protein; Provisional; Region: PRK11027
439843011780	putative ATP-dependent protease; Provisional; Region: PRK09862
439843011781	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
439843011782	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439843011783	Walker A motif; other site
439843011784	ATP binding site [chemical binding]; other site
439843011785	Walker B motif; other site
439843011786	arginine finger; other site
439843011787	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
439843011788	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
439843011789	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
439843011790	PYR/PP interface [polypeptide binding]; other site
439843011791	dimer interface [polypeptide binding]; other site
439843011792	TPP binding site [chemical binding]; other site
439843011793	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
439843011794	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
439843011795	TPP-binding site [chemical binding]; other site
439843011796	dimer interface [polypeptide binding]; other site
439843011797	acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152
439843011798	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
439843011799	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
439843011800	homodimer interface [polypeptide binding]; other site
439843011801	substrate-cofactor binding pocket; other site
439843011802	catalytic residue [active]
439843011803	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
439843011804	threonine dehydratase; Reviewed; Region: PRK09224
439843011805	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
439843011806	tetramer interface [polypeptide binding]; other site
439843011807	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843011808	catalytic residue [active]
439843011809	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
439843011810	putative Ile/Val binding site [chemical binding]; other site
439843011811	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
439843011812	putative Ile/Val binding site [chemical binding]; other site
439843011813	Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365
439843011814	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843011815	DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716
439843011816	The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430
439843011817	putative dimerization interface [polypeptide binding]; other site
439843011818	ketol-acid reductoisomerase; Validated; Region: PRK05225
439843011819	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
439843011820	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
439843011821	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
439843011822	peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441
439843011823	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
439843011824	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
439843011825	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
439843011826	ligand binding site [chemical binding]; other site
439843011827	flexible hinge region; other site
439843011828	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
439843011829	uridine phosphorylase; Provisional; Region: PRK11178
439843011830	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
439843011831	nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397
439843011832	ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919
439843011833	Part of AAA domain; Region: AAA_19; pfam13245
439843011834	Family description; Region: UvrD_C_2; pfam13538
439843011835	guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031
439843011836	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
439843011837	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
439843011838	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
439843011839	ATP binding site [chemical binding]; other site
439843011840	Mg++ binding site [ion binding]; other site
439843011841	motif III; other site
439843011842	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
439843011843	nucleotide binding region [chemical binding]; other site
439843011844	ATP-binding site [chemical binding]; other site
439843011845	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
439843011846	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
439843011847	catalytic residues [active]
439843011848	transcription termination factor Rho; Provisional; Region: rho; PRK09376
439843011849	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
439843011850	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
439843011851	RNA binding site [nucleotide binding]; other site
439843011852	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
439843011853	multimer interface [polypeptide binding]; other site
439843011854	Walker A motif; other site
439843011855	ATP binding site [chemical binding]; other site
439843011856	Walker B motif; other site
439843011857	undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119
439843011858	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
439843011859	Mg++ binding site [ion binding]; other site
439843011860	putative catalytic motif [active]
439843011861	substrate binding site [chemical binding]; other site
439843011862	lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638
439843011863	Chain length determinant protein; Region: Wzz; pfam02706
439843011864	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
439843011865	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
439843011866	active site
439843011867	homodimer interface [polypeptide binding]; other site
439843011868	UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064
439843011869	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
439843011870	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
439843011871	dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217
439843011872	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
439843011873	NAD binding site [chemical binding]; other site
439843011874	substrate binding site [chemical binding]; other site
439843011875	homodimer interface [polypeptide binding]; other site
439843011876	active site
439843011877	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
439843011878	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
439843011879	substrate binding site; other site
439843011880	tetramer interface; other site
439843011881	TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975
439843011882	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
439843011883	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
439843011884	inhibitor-cofactor binding pocket; inhibition site
439843011885	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843011886	catalytic residue [active]
439843011887	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
439843011888	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125
439843011889	4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429
439843011890	putative common antigen polymerase; Provisional; Region: PRK02975
439843011891	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
439843011892	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
439843011893	putative transport protein YifK; Provisional; Region: PRK10746
439843011894	putative protoheme IX biogenesis protein; Provisional; Region: PRK10747
439843011895	HemY protein N-terminus; Region: HemY_N; pfam07219
439843011896	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
439843011897	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959
439843011898	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
439843011899	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
439843011900	active site
439843011901	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
439843011902	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
439843011903	domain interfaces; other site
439843011904	active site
439843011905	Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072
439843011906	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
439843011907	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
439843011908	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503
439843011909	putative iron binding site [ion binding]; other site
439843011910	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
439843011911	Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567
439843011912	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
439843011913	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
439843011914	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
439843011915	hypothetical protein; Provisional; Region: PRK10963
439843011916	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
439843011917	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
439843011918	active site
439843011919	Int/Topo IB signature motif; other site
439843011920	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
439843011921	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439843011922	motif II; other site
439843011923	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
439843011924	Part of AAA domain; Region: AAA_19; pfam13245
439843011925	Family description; Region: UvrD_C_2; pfam13538
439843011926	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
439843011927	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
439843011928	Cl binding site [ion binding]; other site
439843011929	oligomer interface [polypeptide binding]; other site
439843011930	putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430
439843011931	EamA-like transporter family; Region: EamA; cl17759
439843011932	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
439843011933	CoenzymeA binding site [chemical binding]; other site
439843011934	subunit interaction site [polypeptide binding]; other site
439843011935	PHB binding site; other site
439843011936	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
439843011937	dimerization interface [polypeptide binding]; other site
439843011938	substrate binding site [chemical binding]; other site
439843011939	active site
439843011940	calcium binding site [ion binding]; other site
439843011941	ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057
439843011942	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
439843011943	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
439843011944	ATP binding site [chemical binding]; other site
439843011945	ATP binding site [chemical binding]; other site
439843011946	putative Mg++ binding site [ion binding]; other site
439843011947	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
439843011948	nucleotide binding region [chemical binding]; other site
439843011949	ATP-binding site [chemical binding]; other site
439843011950	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
439843011951	Helicase and RNase D C-terminal; Region: HRDC; smart00341
439843011952	threonine efflux system; Provisional; Region: PRK10229
439843011953	homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520
439843011954	lysophospholipase L2; Provisional; Region: PRK10749
439843011955	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
439843011956	putative hydrolase; Provisional; Region: PRK10976
439843011957	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439843011958	active site
439843011959	motif I; other site
439843011960	motif II; other site
439843011961	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439843011962	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
439843011963	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843011964	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
439843011965	putative dimerization interface [polypeptide binding]; other site
439843011966	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
439843011967	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
439843011968	THF binding site; other site
439843011969	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
439843011970	substrate binding site [chemical binding]; other site
439843011971	THF binding site; other site
439843011972	zinc-binding site [ion binding]; other site
439843011973	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
439843011974	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439843011975	FeS/SAM binding site; other site
439843011976	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
439843011977	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
439843011978	uridine phosphorylase; Provisional; Region: PRK11178
439843011979	uridine phosphorylase; Region: Uridine-psphlse; TIGR01718
439843011980	DNA recombination protein RmuC; Provisional; Region: PRK10361
439843011981	RmuC family; Region: RmuC; pfam02646
439843011982	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
439843011983	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439843011984	S-adenosylmethionine binding site [chemical binding]; other site
439843011985	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
439843011986	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
439843011987	SCP-2 sterol transfer family; Region: SCP2; pfam02036
439843011988	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
439843011989	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
439843011990	twin arginine translocase protein A; Provisional; Region: tatA; PRK03554
439843011991	sec-independent translocase; Provisional; Region: PRK01770
439843011992	sec-independent translocase; Provisional; Region: tatB; PRK00404
439843011993	twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921
439843011994	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
439843011995	active site
439843011996	transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014
439843011997	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
439843011998	KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354
439843011999	3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922
439843012000	FMN reductase; Validated; Region: fre; PRK08051
439843012001	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
439843012002	FAD binding pocket [chemical binding]; other site
439843012003	FAD binding motif [chemical binding]; other site
439843012004	phosphate binding motif [ion binding]; other site
439843012005	beta-alpha-beta structure motif; other site
439843012006	NAD binding pocket [chemical binding]; other site
439843012007	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
439843012008	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
439843012009	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
439843012010	dimer interface [polypeptide binding]; other site
439843012011	active site
439843012012	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
439843012013	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
439843012014	substrate binding site [chemical binding]; other site
439843012015	oxyanion hole (OAH) forming residues; other site
439843012016	trimer interface [polypeptide binding]; other site
439843012017	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
439843012018	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
439843012019	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
439843012020	proline dipeptidase; Provisional; Region: PRK13607
439843012021	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
439843012022	active site
439843012023	hypothetical protein; Provisional; Region: PRK11568
439843012024	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
439843012025	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
439843012026	potassium transporter; Provisional; Region: PRK10750
439843012027	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
439843012028	protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104
439843012029	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
439843012030	Walker A motif; other site
439843012031	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
439843012032	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
439843012033	GTP binding site; other site
439843012034	Protein of unknown function (DUF1040); Region: DUF1040; pfam06288
439843012035	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
439843012036	serine/threonine protein kinase; Provisional; Region: PRK11768
439843012037	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
439843012038	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
439843012039	catalytic residues [active]
439843012040	hinge region; other site
439843012041	alpha helical domain; other site
439843012042	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
439843012043	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
439843012044	putative acyl-acceptor binding pocket; other site
439843012045	DNA polymerase I; Provisional; Region: PRK05755
439843012046	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
439843012047	active site
439843012048	metal binding site 1 [ion binding]; metal-binding site
439843012049	putative 5' ssDNA interaction site; other site
439843012050	metal binding site 3; metal-binding site
439843012051	metal binding site 2 [ion binding]; metal-binding site
439843012052	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
439843012053	putative DNA binding site [nucleotide binding]; other site
439843012054	putative metal binding site [ion binding]; other site
439843012055	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
439843012056	active site
439843012057	catalytic site [active]
439843012058	substrate binding site [chemical binding]; other site
439843012059	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
439843012060	active site
439843012061	DNA binding site [nucleotide binding]
439843012062	catalytic site [active]
439843012063	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
439843012064	G1 box; other site
439843012065	GTP/Mg2+ binding site [chemical binding]; other site
439843012066	Switch I region; other site
439843012067	G2 box; other site
439843012068	G3 box; other site
439843012069	Switch II region; other site
439843012070	G4 box; other site
439843012071	G5 box; other site
439843012072	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078
439843012073	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
439843012074	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439843012075	FeS/SAM binding site; other site
439843012076	HemN C-terminal domain; Region: HemN_C; pfam06969
439843012077	nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923
439843012078	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843012079	active site
439843012080	phosphorylation site [posttranslational modification]
439843012081	intermolecular recognition site; other site
439843012082	dimerization interface [polypeptide binding]; other site
439843012083	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439843012084	Walker A motif; other site
439843012085	ATP binding site [chemical binding]; other site
439843012086	Walker B motif; other site
439843012087	arginine finger; other site
439843012088	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
439843012089	nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073
439843012090	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
439843012091	putative active site [active]
439843012092	heme pocket [chemical binding]; other site
439843012093	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439843012094	dimer interface [polypeptide binding]; other site
439843012095	phosphorylation site [posttranslational modification]
439843012096	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439843012097	ATP binding site [chemical binding]; other site
439843012098	Mg2+ binding site [ion binding]; other site
439843012099	G-X-G motif; other site
439843012100	glutamine synthetase; Provisional; Region: glnA; PRK09469
439843012101	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
439843012102	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
439843012103	GTP-binding protein; Provisional; Region: PRK10218
439843012104	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
439843012105	G1 box; other site
439843012106	putative GEF interaction site [polypeptide binding]; other site
439843012107	GTP/Mg2+ binding site [chemical binding]; other site
439843012108	Switch I region; other site
439843012109	G2 box; other site
439843012110	G3 box; other site
439843012111	Switch II region; other site
439843012112	G4 box; other site
439843012113	G5 box; other site
439843012114	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
439843012115	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
439843012116	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439843012117	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
439843012118	active site
439843012119	motif I; other site
439843012120	motif II; other site
439843012121	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439843012122	coproporphyrinogen III oxidase; Validated; Region: PRK08208
439843012123	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439843012124	FeS/SAM binding site; other site
439843012125	HemN C-terminal domain; Region: HemN_C; pfam06969
439843012126	Sulfatase; Region: Sulfatase; cl17466
439843012127	Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189
439843012128	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
439843012129	Leucine-rich repeats; other site
439843012130	Substrate binding site [chemical binding]; other site
439843012131	outer membrane porin L; Provisional; Region: ompL; PRK09980
439843012132	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
439843012133	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843012134	putative substrate translocation pore; other site
439843012135	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
439843012136	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
439843012137	alpha-glucosidase; Provisional; Region: PRK10426
439843012138	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
439843012139	YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594
439843012140	putative active site [active]
439843012141	putative catalytic site [active]
439843012142	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
439843012143	active site
439843012144	catalytic residues [active]
439843012145	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
439843012146	dimerization interface [polypeptide binding]; other site
439843012147	putative active cleft [active]
439843012148	Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684
439843012149	NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461
439843012150	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
439843012151	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
439843012152	Ribokinase-like subgroup B.  Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945
439843012153	substrate binding site [chemical binding]; other site
439843012154	ATP binding site [chemical binding]; other site
439843012155	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
439843012156	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
439843012157	putative DNA binding site [nucleotide binding]; other site
439843012158	putative Zn2+ binding site [ion binding]; other site
439843012159	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
439843012160	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
439843012161	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439843012162	motif II; other site
439843012163	hypothetical protein; Reviewed; Region: PRK01637
439843012164	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
439843012165	putative active site [active]
439843012166	dimerization interface [polypeptide binding]; other site
439843012167	putative tRNAtyr binding site [nucleotide binding]; other site
439843012168	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
439843012169	Coenzyme A binding pocket [chemical binding]; other site
439843012170	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500
439843012171	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
439843012172	non-specific DNA binding site [nucleotide binding]; other site
439843012173	salt bridge; other site
439843012174	sequence-specific DNA binding site [nucleotide binding]; other site
439843012175	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680
439843012176	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
439843012177	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
439843012178	substrate binding pocket [chemical binding]; other site
439843012179	Protein of unknown function (DUF1044); Region: DUF1044; cl01955
439843012180	Predicted transcriptional regulator [Transcription]; Region: COG2944
439843012181	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
439843012182	non-specific DNA binding site [nucleotide binding]; other site
439843012183	salt bridge; other site
439843012184	sequence-specific DNA binding site [nucleotide binding]; other site
439843012185	formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564
439843012186	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
439843012187	formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639
439843012188	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
439843012189	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
439843012190	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
439843012191	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
439843012192	Protein of unknown function (DUF3829); Region: DUF3829; pfam12889
439843012193	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
439843012194	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
439843012195	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
439843012196	non-specific DNA binding site [nucleotide binding]; other site
439843012197	salt bridge; other site
439843012198	sequence-specific DNA binding site [nucleotide binding]; other site
439843012199	Cupin domain; Region: Cupin_2; cl17218
439843012200	L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625
439843012201	lactaldehyde reductase; Region: lactal_redase; TIGR02638
439843012202	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
439843012203	dimer interface [polypeptide binding]; other site
439843012204	active site
439843012205	metal binding site [ion binding]; metal-binding site
439843012206	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
439843012207	intersubunit interface [polypeptide binding]; other site
439843012208	active site
439843012209	Zn2+ binding site [ion binding]; other site
439843012210	L-rhamnose isomerase; Provisional; Region: PRK01076
439843012211	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
439843012212	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
439843012213	N- and C-terminal domain interface [polypeptide binding]; other site
439843012214	active site
439843012215	putative catalytic site [active]
439843012216	metal binding site [ion binding]; metal-binding site
439843012217	ATP binding site [chemical binding]; other site
439843012218	rhamnulokinase; Provisional; Region: rhaB; PRK10640
439843012219	carbohydrate binding site [chemical binding]; other site
439843012220	transcriptional activator RhaS; Provisional; Region: PRK13503
439843012221	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
439843012222	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439843012223	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439843012224	transcriptional activator RhaR; Provisional; Region: PRK13502
439843012225	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
439843012226	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439843012227	L-rhamnose-proton symport protein (RhaT); Region: RhaT; pfam06379
439843012228	RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776
439843012229	Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178
439843012230	DctM-like transporters; Region: DctM; pfam06808
439843012231	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
439843012232	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
439843012233	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
439843012234	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
439843012235	superoxide dismutase; Provisional; Region: PRK10925
439843012236	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
439843012237	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
439843012238	6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536
439843012239	MOSC domain; Region: MOSC; pfam03473
439843012240	3-alpha domain; Region: 3-alpha; pfam03475
439843012241	SnoaL-like domain; Region: SnoaL_2; pfam12680
439843012242	two-component sensor protein; Provisional; Region: cpxA; PRK09470
439843012243	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
439843012244	dimerization interface [polypeptide binding]; other site
439843012245	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439843012246	dimer interface [polypeptide binding]; other site
439843012247	phosphorylation site [posttranslational modification]
439843012248	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439843012249	ATP binding site [chemical binding]; other site
439843012250	Mg2+ binding site [ion binding]; other site
439843012251	G-X-G motif; other site
439843012252	DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955
439843012253	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843012254	active site
439843012255	intermolecular recognition site; other site
439843012256	dimerization interface [polypeptide binding]; other site
439843012257	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
439843012258	DNA binding site [nucleotide binding]
439843012259	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
439843012260	dimer interface [polypeptide binding]; other site
439843012261	ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509
439843012262	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
439843012263	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
439843012264	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
439843012265	active site
439843012266	ADP/pyrophosphate binding site [chemical binding]; other site
439843012267	dimerization interface [polypeptide binding]; other site
439843012268	allosteric effector site; other site
439843012269	fructose-1,6-bisphosphate binding site; other site
439843012270	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
439843012271	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
439843012272	substrate binding pocket [chemical binding]; other site
439843012273	membrane-bound complex binding site; other site
439843012274	hinge residues; other site
439843012275	CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672
439843012276	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
439843012277	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
439843012278	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
439843012279	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
439843012280	putative substrate binding site [chemical binding]; other site
439843012281	putative ATP binding site [chemical binding]; other site
439843012282	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
439843012283	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
439843012284	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439843012285	DNA-binding site [nucleotide binding]; DNA binding site
439843012286	Alanine racemase, C-terminal domain; Region: Ala_racemase_C; cl08293
439843012287	UTRA domain; Region: UTRA; pfam07702
439843012288	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
439843012289	autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939
439843012290	Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775
439843012291	putative N- and C-terminal domain interface [polypeptide binding]; other site
439843012292	putative active site [active]
439843012293	putative MgATP binding site [chemical binding]; other site
439843012294	catalytic site [active]
439843012295	metal binding site [ion binding]; metal-binding site
439843012296	putative carbohydrate binding site [chemical binding]; other site
439843012297	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
439843012298	transcriptional regulator LsrR; Provisional; Region: PRK15418
439843012299	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
439843012300	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
439843012301	autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439
439843012302	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
439843012303	Walker A/P-loop; other site
439843012304	ATP binding site [chemical binding]; other site
439843012305	Q-loop/lid; other site
439843012306	ABC transporter signature motif; other site
439843012307	Walker B; other site
439843012308	D-loop; other site
439843012309	H-loop/switch region; other site
439843012310	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
439843012311	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
439843012312	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
439843012313	TM-ABC transporter signature motif; other site
439843012314	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
439843012315	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
439843012316	TM-ABC transporter signature motif; other site
439843012317	autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408
439843012318	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
439843012319	ligand binding site [chemical binding]; other site
439843012320	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
439843012321	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
439843012322	putative active site; other site
439843012323	catalytic residue [active]
439843012324	autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486
439843012325	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
439843012326	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
439843012327	substrate binding site [chemical binding]; other site
439843012328	hexamer interface [polypeptide binding]; other site
439843012329	metal binding site [ion binding]; metal-binding site
439843012330	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
439843012331	triosephosphate isomerase; Provisional; Region: PRK14567
439843012332	substrate binding site [chemical binding]; other site
439843012333	dimer interface [polypeptide binding]; other site
439843012334	catalytic triad [active]
439843012335	Protein of unknown function (DUF1454); Region: DUF1454; pfam07305
439843012336	Predicted membrane protein [Function unknown]; Region: COG3152
439843012337	ferredoxin-NADP reductase; Provisional; Region: PRK10926
439843012338	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
439843012339	FAD binding pocket [chemical binding]; other site
439843012340	FAD binding motif [chemical binding]; other site
439843012341	phosphate binding motif [ion binding]; other site
439843012342	beta-alpha-beta structure motif; other site
439843012343	NAD binding pocket [chemical binding]; other site
439843012344	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
439843012345	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
439843012346	putative active site [active]
439843012347	glycerol kinase; Provisional; Region: glpK; PRK00047
439843012348	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
439843012349	N- and C-terminal domain interface [polypeptide binding]; other site
439843012350	active site
439843012351	MgATP binding site [chemical binding]; other site
439843012352	catalytic site [active]
439843012353	metal binding site [ion binding]; metal-binding site
439843012354	glycerol binding site [chemical binding]; other site
439843012355	homotetramer interface [polypeptide binding]; other site
439843012356	homodimer interface [polypeptide binding]; other site
439843012357	FBP binding site [chemical binding]; other site
439843012358	protein IIAGlc interface [polypeptide binding]; other site
439843012359	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
439843012360	amphipathic channel; other site
439843012361	Asn-Pro-Ala signature motifs; other site
439843012362	septal ring assembly protein ZapB; Provisional; Region: PRK15422
439843012363	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
439843012364	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751
439843012365	UbiA prenyltransferase family; Region: UbiA; pfam01040
439843012366	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
439843012367	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439843012368	Walker A motif; other site
439843012369	ATP binding site [chemical binding]; other site
439843012370	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
439843012371	Walker B motif; other site
439843012372	arginine finger; other site
439843012373	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
439843012374	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
439843012375	active site
439843012376	HslU subunit interaction site [polypeptide binding]; other site
439843012377	essential cell division protein FtsN; Provisional; Region: PRK10927
439843012378	cell division protein FtsN; Provisional; Region: PRK12757
439843012379	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
439843012380	DNA binding site [nucleotide binding]
439843012381	DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041
439843012382	domain linker motif; other site
439843012383	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
439843012384	dimerization interface [polypeptide binding]; other site
439843012385	ligand binding site [chemical binding]; other site
439843012386	primosome assembly protein PriA; Validated; Region: PRK05580
439843012387	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
439843012388	ATP binding site [chemical binding]; other site
439843012389	putative Mg++ binding site [ion binding]; other site
439843012390	helicase superfamily c-terminal domain; Region: HELICc; smart00490
439843012391	ATP-binding site [chemical binding]; other site
439843012392	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
439843012393	conserved hypothetical protein; Region: chp_urease_rgn; TIGR02117
439843012394	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
439843012395	Met Repressor, MetJ.  MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490
439843012396	dimerization interface [polypeptide binding]; other site
439843012397	DNA binding site [nucleotide binding]
439843012398	corepressor binding sites; other site
439843012399	cystathionine gamma-synthase; Provisional; Region: PRK08045
439843012400	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
439843012401	homodimer interface [polypeptide binding]; other site
439843012402	substrate-cofactor binding pocket; other site
439843012403	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843012404	catalytic residue [active]
439843012405	bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466
439843012406	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
439843012407	putative catalytic residues [active]
439843012408	putative nucleotide binding site [chemical binding]; other site
439843012409	putative aspartate binding site [chemical binding]; other site
439843012410	ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892
439843012411	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
439843012412	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
439843012413	aspartate aminotransferase; Provisional; Region: PRK06836
439843012414	Insertion element protein; Region: Ins_element1; pfam03811
439843012415	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
439843012416	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
439843012417	active site
439843012418	metal binding site [ion binding]; metal-binding site
439843012419	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
439843012420	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
439843012421	FAD binding site [chemical binding]; other site
439843012422	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
439843012423	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
439843012424	heme binding site [chemical binding]; other site
439843012425	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
439843012426	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
439843012427	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
439843012428	dimer interface [polypeptide binding]; other site
439843012429	active site
439843012430	metal binding site [ion binding]; metal-binding site
439843012431	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
439843012432	active site
439843012433	intersubunit interactions; other site
439843012434	catalytic residue [active]
439843012435	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
439843012436	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439843012437	hypothetical protein; Provisional; Region: PRK10649
439843012438	Sulfatase; Region: Sulfatase; pfam00884
439843012439	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
439843012440	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
439843012441	acetylornithine deacetylase; Provisional; Region: PRK05111
439843012442	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
439843012443	metal binding site [ion binding]; metal-binding site
439843012444	putative dimer interface [polypeptide binding]; other site
439843012445	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
439843012446	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
439843012447	AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249
439843012448	nucleotide binding site [chemical binding]; other site
439843012449	N-acetyl-L-glutamate binding site [chemical binding]; other site
439843012450	argininosuccinate lyase; Provisional; Region: PRK04833
439843012451	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
439843012452	active sites [active]
439843012453	tetramer interface [polypeptide binding]; other site
439843012454	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
439843012455	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843012456	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
439843012457	dimerization interface [polypeptide binding]; other site
439843012458	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
439843012459	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
439843012460	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
439843012461	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
439843012462	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
439843012463	hypothetical protein; Provisional; Region: PRK11056
439843012464	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
439843012465	Protein of unknown function (DUF3164); Region: DUF3164; pfam11363
439843012466	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439843012467	S-adenosylmethionine binding site [chemical binding]; other site
439843012468	vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641
439843012469	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
439843012470	N-terminal plug; other site
439843012471	ligand-binding site [chemical binding]; other site
439843012472	glutamate racemase; Provisional; Region: PRK00865
439843012473	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
439843012474	FAD binding domain; Region: FAD_binding_4; pfam01565
439843012475	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
439843012476	Biotin operon repressor [Transcription]; Region: BirA; COG1654
439843012477	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
439843012478	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
439843012479	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
439843012480	pantothenate kinase; Provisional; Region: PRK05439
439843012481	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
439843012482	ATP-binding site [chemical binding]; other site
439843012483	CoA-binding site [chemical binding]; other site
439843012484	Mg2+-binding site [ion binding]; other site
439843012485	elongation factor Tu; Reviewed; Region: PRK00049
439843012486	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
439843012487	G1 box; other site
439843012488	GEF interaction site [polypeptide binding]; other site
439843012489	GTP/Mg2+ binding site [chemical binding]; other site
439843012490	Switch I region; other site
439843012491	G2 box; other site
439843012492	G3 box; other site
439843012493	Switch II region; other site
439843012494	G4 box; other site
439843012495	G5 box; other site
439843012496	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
439843012497	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
439843012498	Antibiotic Binding Site [chemical binding]; other site
439843012499	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
439843012500	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
439843012501	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
439843012502	putative homodimer interface [polypeptide binding]; other site
439843012503	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
439843012504	heterodimer interface [polypeptide binding]; other site
439843012505	homodimer interface [polypeptide binding]; other site
439843012506	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
439843012507	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
439843012508	23S rRNA interface [nucleotide binding]; other site
439843012509	L7/L12 interface [polypeptide binding]; other site
439843012510	putative thiostrepton binding site; other site
439843012511	L25 interface [polypeptide binding]; other site
439843012512	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
439843012513	mRNA/rRNA interface [nucleotide binding]; other site
439843012514	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
439843012515	23S rRNA interface [nucleotide binding]; other site
439843012516	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
439843012517	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
439843012518	core dimer interface [polypeptide binding]; other site
439843012519	peripheral dimer interface [polypeptide binding]; other site
439843012520	L10 interface [polypeptide binding]; other site
439843012521	L11 interface [polypeptide binding]; other site
439843012522	putative EF-Tu interaction site [polypeptide binding]; other site
439843012523	putative EF-G interaction site [polypeptide binding]; other site
439843012524	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
439843012525	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
439843012526	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
439843012527	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
439843012528	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
439843012529	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
439843012530	RPB3 interaction site [polypeptide binding]; other site
439843012531	RPB1 interaction site [polypeptide binding]; other site
439843012532	RPB11 interaction site [polypeptide binding]; other site
439843012533	RPB10 interaction site [polypeptide binding]; other site
439843012534	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
439843012535	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
439843012536	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
439843012537	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
439843012538	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
439843012539	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
439843012540	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
439843012541	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
439843012542	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
439843012543	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
439843012544	DNA binding site [nucleotide binding]
439843012545	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
439843012546	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
439843012547	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439843012548	FeS/SAM binding site; other site
439843012549	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
439843012550	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
439843012551	ThiS interaction site; other site
439843012552	putative active site [active]
439843012553	tetramer interface [polypeptide binding]; other site
439843012554	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
439843012555	thiS-thiF/thiG interaction site; other site
439843012556	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
439843012557	thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356
439843012558	ATP binding site [chemical binding]; other site
439843012559	substrate interface [chemical binding]; other site
439843012560	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
439843012561	thiamine phosphate binding site [chemical binding]; other site
439843012562	active site
439843012563	pyrophosphate binding site [ion binding]; other site
439843012564	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
439843012565	ThiC-associated domain; Region: ThiC-associated; pfam13667
439843012566	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
439843012567	Regulator of sigma D [Transcription]; Region: Rsd; COG3160
439843012568	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
439843012569	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
439843012570	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
439843012571	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
439843012572	putative NADH binding site [chemical binding]; other site
439843012573	putative active site [active]
439843012574	nudix motif; other site
439843012575	putative metal binding site [ion binding]; other site
439843012576	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
439843012577	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
439843012578	substrate binding site [chemical binding]; other site
439843012579	active site
439843012580	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
439843012581	Active_site [active]
439843012582	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068
439843012583	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
439843012584	IHF dimer interface [polypeptide binding]; other site
439843012585	IHF - DNA interface [nucleotide binding]; other site
439843012586	Protein of unknown function (DUF1481); Region: DUF1481; pfam07356
439843012587	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
439843012588	dimer interface [polypeptide binding]; other site
439843012589	sensor protein ZraS; Provisional; Region: PRK10364
439843012590	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439843012591	dimer interface [polypeptide binding]; other site
439843012592	phosphorylation site [posttranslational modification]
439843012593	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439843012594	ATP binding site [chemical binding]; other site
439843012595	Mg2+ binding site [ion binding]; other site
439843012596	G-X-G motif; other site
439843012597	transcriptional regulatory protein ZraR; Provisional; Region: PRK10365
439843012598	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843012599	active site
439843012600	phosphorylation site [posttranslational modification]
439843012601	intermolecular recognition site; other site
439843012602	dimerization interface [polypeptide binding]; other site
439843012603	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439843012604	Walker A motif; other site
439843012605	ATP binding site [chemical binding]; other site
439843012606	Walker B motif; other site
439843012607	arginine finger; other site
439843012608	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
439843012609	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
439843012610	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
439843012611	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
439843012612	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
439843012613	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
439843012614	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
439843012615	purine monophosphate binding site [chemical binding]; other site
439843012616	dimer interface [polypeptide binding]; other site
439843012617	putative catalytic residues [active]
439843012618	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
439843012619	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
439843012620	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
439843012621	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
439843012622	Coenzyme A binding pocket [chemical binding]; other site
439843012623	homoserine O-succinyltransferase; Provisional; Region: PRK05368
439843012624	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
439843012625	proposed active site lysine [active]
439843012626	conserved cys residue [active]
439843012627	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
439843012628	malate synthase A; Region: malate_syn_A; TIGR01344
439843012629	active site
439843012630	isocitrate lyase; Provisional; Region: PRK15063
439843012631	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
439843012632	tetramer interface [polypeptide binding]; other site
439843012633	active site
439843012634	Mg2+/Mn2+ binding site [ion binding]; other site
439843012635	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
439843012636	bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946
439843012637	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
439843012638	transcriptional repressor IclR; Provisional; Region: PRK11569
439843012639	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
439843012640	Bacterial transcriptional regulator; Region: IclR; pfam01614
439843012641	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
439843012642	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
439843012643	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
439843012644	substrate binding pocket [chemical binding]; other site
439843012645	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
439843012646	B12 binding site [chemical binding]; other site
439843012647	cobalt ligand [ion binding]; other site
439843012648	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
439843012649	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
439843012650	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
439843012651	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
439843012652	active site pocket [active]
439843012653	oxyanion hole [active]
439843012654	catalytic triad [active]
439843012655	active site nucleophile [active]
439843012656	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122
439843012657	23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475
439843012658	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
439843012659	RNA binding surface [nucleotide binding]; other site
439843012660	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
439843012661	probable active site [active]
439843012662	hypothetical protein; Provisional; Region: PRK10515
439843012663	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
439843012664	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
439843012665	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
439843012666	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
439843012667	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
439843012668	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
439843012669	active site
439843012670	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
439843012671	phosphate binding site [ion binding]; other site
439843012672	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
439843012673	aspartate kinase III; Validated; Region: PRK09084
439843012674	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
439843012675	nucleotide binding site [chemical binding]; other site
439843012676	substrate binding site [chemical binding]; other site
439843012677	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
439843012678	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917
439843012679	dimer interface [polypeptide binding]; other site
439843012680	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
439843012681	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
439843012682	active site
439843012683	dimer interface [polypeptide binding]; other site
439843012684	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
439843012685	dimer interface [polypeptide binding]; other site
439843012686	active site
439843012687	Exopolysaccharide production protein YjbE; Region: YjbE; pfam11106
439843012688	Protein of unknown function (DUF2886); Region: DUF2886; pfam11102
439843012689	Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251
439843012690	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
439843012691	Predicted membrane protein [Function unknown]; Region: COG3223
439843012692	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
439843012693	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843012694	putative substrate translocation pore; other site
439843012695	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
439843012696	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843012697	dimer interface [polypeptide binding]; other site
439843012698	conserved gate region; other site
439843012699	putative PBP binding loops; other site
439843012700	ABC-ATPase subunit interface; other site
439843012701	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
439843012702	dimer interface [polypeptide binding]; other site
439843012703	conserved gate region; other site
439843012704	putative PBP binding loops; other site
439843012705	ABC-ATPase subunit interface; other site
439843012706	maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474
439843012707	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
439843012708	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
439843012709	maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000
439843012710	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
439843012711	Walker A/P-loop; other site
439843012712	ATP binding site [chemical binding]; other site
439843012713	Q-loop/lid; other site
439843012714	ABC transporter signature motif; other site
439843012715	Walker B; other site
439843012716	D-loop; other site
439843012717	H-loop/switch region; other site
439843012718	TOBE domain; Region: TOBE_2; pfam08402
439843012719	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
439843012720	trimer interface; other site
439843012721	sugar binding site [chemical binding]; other site
439843012722	maltose regulon periplasmic protein; Provisional; Region: PRK10564
439843012723	chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655
439843012724	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
439843012725	UbiA prenyltransferase family; Region: UbiA; pfam01040
439843012726	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
439843012727	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
439843012728	putative acyl-acceptor binding pocket; other site
439843012729	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
439843012730	LexA repressor; Validated; Region: PRK00215
439843012731	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
439843012732	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
439843012733	Catalytic site [active]
439843012734	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
439843012735	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
439843012736	hypothetical protein; Provisional; Region: PRK10428
439843012737	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
439843012738	metal binding site 2 [ion binding]; metal-binding site
439843012739	putative DNA binding helix; other site
439843012740	metal binding site 1 [ion binding]; metal-binding site
439843012741	dimer interface [polypeptide binding]; other site
439843012742	structural Zn2+ binding site [ion binding]; other site
439843012743	F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729
439843012744	Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935
439843012745	HD domain; Region: HD_3; cl17350
439843012746	Uncharacterized conserved protein (DUF2303); Region: DUF2303; pfam10065
439843012747	DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744
439843012748	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439843012749	DNA-binding site [nucleotide binding]; DNA binding site
439843012750	DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869
439843012751	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
439843012752	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
439843012753	KilA-N domain; Region: KilA-N; pfam04383
439843012754	Protein of unknown function (DUF968); Region: DUF968; pfam06147
439843012755	Antitermination protein; Region: Antiterm; pfam03589
439843012756	DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684
439843012757	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
439843012758	Zn binding sites [ion binding]; other site
439843012759	Antitermination protein; Region: Antiterm; pfam03589
439843012760	Protein of unknown function (DUF754); Region: DUF754; pfam05449
439843012761	Predicted chitinase [General function prediction only]; Region: COG3179
439843012762	Protein of unknown function (DUF2514); Region: DUF2514; pfam10721
439843012763	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
439843012764	active site
439843012765	Phage terminase, small subunit; Region: Terminase_4; pfam05119
439843012766	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
439843012767	Phage-related protein [Function unknown]; Region: COG4695
439843012768	Phage portal protein; Region: Phage_portal; pfam04860
439843012769	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
439843012770	oligomer interface [polypeptide binding]; other site
439843012771	active site residues [active]
439843012772	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
439843012773	Phage capsid family; Region: Phage_capsid; pfam05065
439843012774	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
439843012775	oligomerization interface [polypeptide binding]; other site
439843012776	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
439843012777	Protein of unknown function (DUF2635); Region: DUF2635; pfam10948
439843012778	Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386
439843012779	Phage tail sheath protein; Region: Phage_sheath_1; pfam04984
439843012780	Phage tail tube protein; Region: Tail_tube; pfam10618
439843012781	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
439843012782	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
439843012783	Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228
439843012784	DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157
439843012785	Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379
439843012786	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
439843012787	Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; pfam06890
439843012788	Phage protein GP46; Region: GP46; pfam07409
439843012789	Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299
439843012790	Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076
439843012791	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
439843012792	type III secretion protein SopE; Provisional; Region: PRK15279
439843012793	Salmonella type III secretion SopE effector N-terminus; Region: SecIII_SopE_N; pfam05364
439843012794	SopE GEF domain; Region: SopE_GEF; pfam07487
439843012795	multiple promoter invertase; Provisional; Region: mpi; PRK13413
439843012796	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
439843012797	catalytic residues [active]
439843012798	catalytic nucleophile [active]
439843012799	Presynaptic Site I dimer interface [polypeptide binding]; other site
439843012800	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
439843012801	Synaptic Flat tetramer interface [polypeptide binding]; other site
439843012802	Synaptic Site I dimer interface [polypeptide binding]; other site
439843012803	DNA binding site [nucleotide binding]
439843012804	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
439843012805	DNA-binding interface [nucleotide binding]; DNA binding site
439843012806	DinI-like family; Region: DinI; pfam06183
439843012807	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
439843012808	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
439843012809	active site
439843012810	DNA binding site [nucleotide binding]
439843012811	Int/Topo IB signature motif; other site
439843012812	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
439843012813	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
439843012814	FMN binding site [chemical binding]; other site
439843012815	active site
439843012816	catalytic residues [active]
439843012817	substrate binding site [chemical binding]; other site
439843012818	phage shock protein G; Reviewed; Region: pspG; PRK09459
439843012819	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
439843012820	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
439843012821	NADP binding site [chemical binding]; other site
439843012822	dimer interface [polypeptide binding]; other site
439843012823	replicative DNA helicase; Provisional; Region: PRK08006
439843012824	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
439843012825	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
439843012826	Walker A motif; other site
439843012827	ATP binding site [chemical binding]; other site
439843012828	Walker B motif; other site
439843012829	DNA binding loops [nucleotide binding]
439843012830	alanine racemase; Reviewed; Region: alr; PRK00053
439843012831	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
439843012832	active site
439843012833	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
439843012834	substrate binding site [chemical binding]; other site
439843012835	catalytic residues [active]
439843012836	dimer interface [polypeptide binding]; other site
439843012837	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
439843012838	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
439843012839	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843012840	homodimer interface [polypeptide binding]; other site
439843012841	catalytic residue [active]
439843012842	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439843012843	active site
439843012844	motif I; other site
439843012845	motif II; other site
439843012846	Uncharacterized conserved protein [Function unknown]; Region: COG0432
439843012847	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
439843012848	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
439843012849	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
439843012850	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
439843012851	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
439843012852	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
439843012853	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
439843012854	dimer interface [polypeptide binding]; other site
439843012855	ssDNA binding site [nucleotide binding]; other site
439843012856	tetramer (dimer of dimers) interface [polypeptide binding]; other site
439843012857	hypothetical protein; Validated; Region: PRK09039
439843012858	Zinc finger-containing protein; Region: zf-C4H2; pfam10146
439843012859	Outer membrane efflux protein; Region: OEP; pfam02321
439843012860	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
439843012861	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439843012862	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439843012863	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439843012864	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439843012865	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439843012866	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
439843012867	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
439843012868	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439843012869	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
439843012870	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439843012871	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
439843012872	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
439843012873	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439843012874	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
439843012875	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
439843012876	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439843012877	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
439843012878	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439843012879	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
439843012880	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
439843012881	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439843012882	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
439843012883	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
439843012884	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439843012885	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
439843012886	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439843012887	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439843012888	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
439843012889	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439843012890	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439843012891	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439843012892	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439843012893	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439843012894	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439843012895	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
439843012896	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439843012897	Bacterial Ig-like domain (group 3); Region: Big_3_2; pfam12245
439843012898	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439843012899	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439843012900	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
439843012901	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
439843012902	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
439843012903	Walker A/P-loop; other site
439843012904	ATP binding site [chemical binding]; other site
439843012905	Q-loop/lid; other site
439843012906	ABC transporter signature motif; other site
439843012907	Walker B; other site
439843012908	D-loop; other site
439843012909	H-loop/switch region; other site
439843012910	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
439843012911	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
439843012912	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
439843012913	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
439843012914	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439843012915	redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002
439843012916	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
439843012917	DNA binding residues [nucleotide binding]
439843012918	dimer interface [polypeptide binding]; other site
439843012919	[2Fe-2S] cluster binding site [ion binding]; other site
439843012920	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
439843012921	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
439843012922	putative C-terminal domain interface [polypeptide binding]; other site
439843012923	putative GSH binding site (G-site) [chemical binding]; other site
439843012924	putative dimer interface [polypeptide binding]; other site
439843012925	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
439843012926	putative N-terminal domain interface [polypeptide binding]; other site
439843012927	putative dimer interface [polypeptide binding]; other site
439843012928	putative substrate binding pocket (H-site) [chemical binding]; other site
439843012929	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
439843012930	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
439843012931	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
439843012932	Transcriptional regulator [Transcription]; Region: LysR; COG0583
439843012933	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843012934	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
439843012935	putative dimerization interface [polypeptide binding]; other site
439843012936	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
439843012937	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
439843012938	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
439843012939	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
439843012940	Na binding site [ion binding]; other site
439843012941	Predicted membrane protein [Function unknown]; Region: COG3162
439843012942	acetyl-CoA synthetase; Provisional; Region: PRK00174
439843012943	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
439843012944	active site
439843012945	CoA binding site [chemical binding]; other site
439843012946	acyl-activating enzyme (AAE) consensus motif; other site
439843012947	AMP binding site [chemical binding]; other site
439843012948	acetate binding site [chemical binding]; other site
439843012949	cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125
439843012950	cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659
439843012951	cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149
439843012952	Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301
439843012953	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
439843012954	heme lyase subunit NrfE; Provisional; Region: PRK10369
439843012955	formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144
439843012956	formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370
439843012957	glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283
439843012958	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
439843012959	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
439843012960	Sel1-like repeats; Region: SEL1; smart00671
439843012961	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
439843012962	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
439843012963	Coenzyme A binding pocket [chemical binding]; other site
439843012964	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
439843012965	dimer interface [polypeptide binding]; other site
439843012966	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
439843012967	hypothetical protein; Provisional; Region: PRK10220
439843012968	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
439843012969	PhnA protein; Region: PhnA; pfam03831
439843012970	proline/glycine betaine transporter; Provisional; Region: PRK10642
439843012971	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843012972	putative substrate translocation pore; other site
439843012973	Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946
439843012974	sensor protein BasS/PmrB; Provisional; Region: PRK10755
439843012975	HAMP domain; Region: HAMP; pfam00672
439843012976	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439843012977	dimer interface [polypeptide binding]; other site
439843012978	phosphorylation site [posttranslational modification]
439843012979	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439843012980	ATP binding site [chemical binding]; other site
439843012981	Mg2+ binding site [ion binding]; other site
439843012982	G-X-G motif; other site
439843012983	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
439843012984	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843012985	active site
439843012986	phosphorylation site [posttranslational modification]
439843012987	intermolecular recognition site; other site
439843012988	dimerization interface [polypeptide binding]; other site
439843012989	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
439843012990	DNA binding site [nucleotide binding]
439843012991	putative metal dependent hydrolase; Provisional; Region: PRK11598
439843012992	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
439843012993	Sulfatase; Region: Sulfatase; pfam00884
439843012994	arginine:agmatin antiporter; Provisional; Region: PRK10644
439843012995	DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978
439843012996	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439843012997	arginine decarboxylase; Provisional; Region: PRK15029
439843012998	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
439843012999	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
439843013000	homodimer interface [polypeptide binding]; other site
439843013001	pyridoxal 5'-phosphate binding site [chemical binding]; other site
439843013002	catalytic residue [active]
439843013003	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
439843013004	DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371
439843013005	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439843013006	alpha-galactosidase; Provisional; Region: PRK15076
439843013007	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
439843013008	NAD binding site [chemical binding]; other site
439843013009	sugar binding site [chemical binding]; other site
439843013010	divalent metal binding site [ion binding]; other site
439843013011	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
439843013012	dimer interface [polypeptide binding]; other site
439843013013	melibiose:sodium symporter; Provisional; Region: PRK10429
439843013014	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
439843013015	fumarate hydratase; Provisional; Region: PRK15389
439843013016	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951
439843013017	Fumarase C-terminus; Region: Fumerase_C; pfam05683
439843013018	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
439843013019	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489
439843013020	DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430
439843013021	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843013022	active site
439843013023	phosphorylation site [posttranslational modification]
439843013024	intermolecular recognition site; other site
439843013025	dimerization interface [polypeptide binding]; other site
439843013026	sensory histidine kinase DcuS; Provisional; Region: PRK11086
439843013027	PAS domain; Region: PAS; smart00091
439843013028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439843013029	ATP binding site [chemical binding]; other site
439843013030	Mg2+ binding site [ion binding]; other site
439843013031	G-X-G motif; other site
439843013032	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
439843013033	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
439843013034	putative [Fe4-S4] binding site [ion binding]; other site
439843013035	putative molybdopterin cofactor binding site [chemical binding]; other site
439843013036	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
439843013037	putative molybdopterin cofactor binding site; other site
439843013038	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
439843013039	DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519
439843013040	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
439843013041	Domain of unknown function (DUF1996); Region: DUF1996; pfam09362
439843013042	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204
439843013043	SdiA-regulated; Region: SdiA-regulated; cd09971
439843013044	putative active site [active]
439843013045	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
439843013046	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
439843013047	DNA binding residues [nucleotide binding]
439843013048	dimerization interface [polypeptide binding]; other site
439843013049	AraC family transcriptional regulator; Provisional; Region: PRK15186
439843013050	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439843013051	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
439843013052	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
439843013053	Coenzyme A binding pocket [chemical binding]; other site
439843013054	fimbriae biosynthesis regulatory protein; Provisional; Region: PRK15215
439843013055	Fimbrial protein; Region: Fimbrial; pfam00419
439843013056	fimbrial outer membrane usher protein PefC; Provisional; Region: PRK15213
439843013057	PapC N-terminal domain; Region: PapC_N; pfam13954
439843013058	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
439843013059	PapC C-terminal domain; Region: PapC_C; pfam13953
439843013060	fimbrial chaperone protein PefD; Provisional; Region: PRK15211
439843013061	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
439843013062	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
439843013063	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
439843013064	Fimbrial, major and minor subunit; Region: Fimbrial_K88; pfam02432
439843013065	Fimbrial, major and minor subunit; Region: Fimbrial_K88; pfam02432
439843013066	Fimbrial, major and minor subunit; Region: Fimbrial_K88; pfam02432
439843013067	FaeA-like protein; Region: FaeA; pfam04703
439843013068	SdiA-regulated; Region: SdiA-regulated; pfam06977
439843013069	SdiA-regulated; Region: SdiA-regulated; cd09971
439843013070	putative active site [active]
439843013071	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
439843013072	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
439843013073	active site
439843013074	putative transcriptional regulator; Provisional; Region: PRK11640
439843013075	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
439843013076	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
439843013077	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
439843013078	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
439843013079	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
439843013080	DsbD alpha interface [polypeptide binding]; other site
439843013081	catalytic residues [active]
439843013082	divalent-cation tolerance protein CutA; Provisional; Region: PRK10645
439843013083	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
439843013084	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
439843013085	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
439843013086	Aspartase; Region: Aspartase; cd01357
439843013087	active sites [active]
439843013088	tetramer interface [polypeptide binding]; other site
439843013089	Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030
439843013090	putative transporter; Provisional; Region: PRK11021
439843013091	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
439843013092	oligomerisation interface [polypeptide binding]; other site
439843013093	mobile loop; other site
439843013094	roof hairpin; other site
439843013095	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
439843013096	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
439843013097	ring oligomerisation interface [polypeptide binding]; other site
439843013098	ATP/Mg binding site [chemical binding]; other site
439843013099	stacking interactions; other site
439843013100	hinge regions; other site
439843013101	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
439843013102	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
439843013103	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439843013104	FeS/SAM binding site; other site
439843013105	elongation factor P; Validated; Region: PRK00529
439843013106	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
439843013107	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
439843013108	RNA binding site [nucleotide binding]; other site
439843013109	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
439843013110	RNA binding site [nucleotide binding]; other site
439843013111	Predicted small secreted protein [Function unknown]; Region: COG5510
439843013112	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
439843013113	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
439843013114	DNA binding residues [nucleotide binding]
439843013115	dimerization interface [polypeptide binding]; other site
439843013116	multidrug efflux system protein; Provisional; Region: PRK11431
439843013117	outer membrane lipoprotein Blc; Provisional; Region: PRK10477
439843013118	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
439843013119	Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547
439843013120	Iron-sulfur protein interface; other site
439843013121	proximal quinone binding site [chemical binding]; other site
439843013122	C-subunit interface; other site
439843013123	distal quinone binding site; other site
439843013124	Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546
439843013125	D-subunit interface [polypeptide binding]; other site
439843013126	Iron-sulfur protein interface; other site
439843013127	proximal quinone binding site [chemical binding]; other site
439843013128	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385
439843013129	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
439843013130	fumarate reductase flavoprotein subunit; Validated; Region: PRK09231
439843013131	L-aspartate oxidase; Provisional; Region: PRK06175
439843013132	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
439843013133	poxB regulator PoxA; Provisional; Region: PRK09350
439843013134	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
439843013135	motif 1; other site
439843013136	dimer interface [polypeptide binding]; other site
439843013137	active site
439843013138	motif 2; other site
439843013139	motif 3; other site
439843013140	inner membrane transporter YjeM; Provisional; Region: PRK15238
439843013141	putative mechanosensitive channel protein; Provisional; Region: PRK10929
439843013142	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
439843013143	Mechanosensitive ion channel; Region: MS_channel; pfam00924
439843013144	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
439843013145	GTPase RsgA; Reviewed; Region: PRK12288
439843013146	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
439843013147	RNA binding site [nucleotide binding]; other site
439843013148	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
439843013149	GTPase/Zn-binding domain interface [polypeptide binding]; other site
439843013150	GTP/Mg2+ binding site [chemical binding]; other site
439843013151	G4 box; other site
439843013152	G5 box; other site
439843013153	G1 box; other site
439843013154	Switch I region; other site
439843013155	G2 box; other site
439843013156	G3 box; other site
439843013157	Switch II region; other site
439843013158	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
439843013159	catalytic site [active]
439843013160	putative active site [active]
439843013161	putative substrate binding site [chemical binding]; other site
439843013162	dimer interface [polypeptide binding]; other site
439843013163	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
439843013164	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
439843013165	substrate binding pocket [chemical binding]; other site
439843013166	membrane-bound complex binding site; other site
439843013167	hinge residues; other site
439843013168	epoxyqueuosine reductase; Region: TIGR00276
439843013169	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
439843013170	putative carbohydrate kinase; Provisional; Region: PRK10565
439843013171	Uncharacterized conserved protein [Function unknown]; Region: COG0062
439843013172	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
439843013173	putative substrate binding site [chemical binding]; other site
439843013174	putative ATP binding site [chemical binding]; other site
439843013175	ADP-binding protein; Provisional; Region: PRK10646
439843013176	N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431
439843013177	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
439843013178	active site
439843013179	metal binding site [ion binding]; metal-binding site
439843013180	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
439843013181	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439843013182	ATP binding site [chemical binding]; other site
439843013183	Mg2+ binding site [ion binding]; other site
439843013184	G-X-G motif; other site
439843013185	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
439843013186	ATP binding site [chemical binding]; other site
439843013187	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
439843013188	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
439843013189	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
439843013190	bacterial Hfq-like; Region: Hfq; cd01716
439843013191	hexamer interface [polypeptide binding]; other site
439843013192	Sm1 motif; other site
439843013193	RNA binding site [nucleotide binding]; other site
439843013194	Sm2 motif; other site
439843013195	GTPase HflX; Provisional; Region: PRK11058
439843013196	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
439843013197	HflX GTPase family; Region: HflX; cd01878
439843013198	G1 box; other site
439843013199	GTP/Mg2+ binding site [chemical binding]; other site
439843013200	Switch I region; other site
439843013201	G2 box; other site
439843013202	G3 box; other site
439843013203	Switch II region; other site
439843013204	G4 box; other site
439843013205	G5 box; other site
439843013206	FtsH protease regulator HflK; Provisional; Region: PRK10930
439843013207	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
439843013208	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
439843013209	FtsH protease regulator HflC; Provisional; Region: PRK11029
439843013210	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
439843013211	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242
439843013212	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
439843013213	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
439843013214	GDP-binding site [chemical binding]; other site
439843013215	ACT binding site; other site
439843013216	IMP binding site; other site
439843013217	Predicted transcriptional regulator [Transcription]; Region: COG1959
439843013218	transcriptional repressor NsrR; Provisional; Region: PRK11014
439843013219	exoribonuclease R; Provisional; Region: PRK11642
439843013220	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
439843013221	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
439843013222	RNB domain; Region: RNB; pfam00773
439843013223	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
439843013224	RNA binding site [nucleotide binding]; other site
439843013225	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
439843013226	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
439843013227	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
439843013228	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3789
439843013229	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
439843013230	Protein of unknown function (DUF2491); Region: DUF2491; pfam10679
439843013231	Predicted membrane protein [Function unknown]; Region: COG3766
439843013232	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
439843013233	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
439843013234	Predicted integral membrane protein [Function unknown]; Region: COG5463
439843013235	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
439843013236	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
439843013237	Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154
439843013238	FAD binding site [chemical binding]; other site
439843013239	substrate binding site [chemical binding]; other site
439843013240	catalytic residues [active]
439843013241	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
439843013242	putative biofilm stress and motility protein A; Provisional; Region: PRK14864
439843013243	esterase; Provisional; Region: PRK10566
439843013244	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
439843013245	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
439843013246	transcriptional repressor UlaR; Provisional; Region: PRK13509
439843013247	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
439843013248	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
439843013249	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
439843013250	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
439843013251	Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037
439843013252	PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548
439843013253	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
439843013254	active site
439843013255	P-loop; other site
439843013256	phosphorylation site [posttranslational modification]
439843013257	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
439843013258	active site
439843013259	phosphorylation site [posttranslational modification]
439843013260	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
439843013261	active site
439843013262	dimer interface [polypeptide binding]; other site
439843013263	magnesium binding site [ion binding]; other site
439843013264	L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209
439843013265	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
439843013266	AP (apurinic/apyrimidinic) site pocket; other site
439843013267	DNA interaction; other site
439843013268	Metal-binding active site; metal-binding site
439843013269	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
439843013270	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
439843013271	intersubunit interface [polypeptide binding]; other site
439843013272	active site
439843013273	Zn2+ binding site [ion binding]; other site
439843013274	Protein of unknown function (DUF1440); Region: DUF1440; cl01380
439843013275	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
439843013276	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
439843013277	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
439843013278	dimer interface [polypeptide binding]; other site
439843013279	ssDNA binding site [nucleotide binding]; other site
439843013280	tetramer (dimer of dimers) interface [polypeptide binding]; other site
439843013281	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
439843013282	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
439843013283	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
439843013284	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
439843013285	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
439843013286	EamA-like transporter family; Region: EamA; pfam00892
439843013287	Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061
439843013288	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
439843013289	peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570
439843013290	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
439843013291	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
439843013292	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
439843013293	iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992
439843013294	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
439843013295	Hemerythrin-like domain; Region: Hr-like; cd12108
439843013296	Fe binding site [ion binding]; other site
439843013297	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
439843013298	EamA-like transporter family; Region: EamA; pfam00892
439843013299	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
439843013300	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
439843013301	NADP binding site [chemical binding]; other site
439843013302	Predicted transcriptional regulators [Transcription]; Region: COG1733
439843013303	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
439843013304	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
439843013305	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
439843013306	active site
439843013307	metal binding site [ion binding]; metal-binding site
439843013308	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
439843013309	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
439843013310	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
439843013311	active site
439843013312	Predicted transcriptional regulator [General function prediction only]; Region: COG3054
439843013313	Protein of unknown function (DUF1107); Region: DUF1107; pfam06526
439843013314	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
439843013315	Domain of unknown function DUF21; Region: DUF21; pfam01595
439843013316	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
439843013317	Transporter associated domain; Region: CorC_HlyC; smart01091
439843013318	methionine sulfoxide reductase A; Provisional; Region: PRK00058
439843013319	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
439843013320	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
439843013321	Surface antigen; Region: Bac_surface_Ag; pfam01103
439843013322	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
439843013323	Family of unknown function (DUF490); Region: DUF490; pfam04357
439843013324	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
439843013325	putative active site pocket [active]
439843013326	dimerization interface [polypeptide binding]; other site
439843013327	putative catalytic residue [active]
439843013328	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843013329	D-galactonate transporter; Region: 2A0114; TIGR00893
439843013330	putative substrate translocation pore; other site
439843013331	putative metallo-dependent hydrolase; Provisional; Region: PRK12394
439843013332	Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307
439843013333	active site
439843013334	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
439843013335	dimer interface [polypeptide binding]; other site
439843013336	substrate binding site [chemical binding]; other site
439843013337	metal binding sites [ion binding]; metal-binding site
439843013338	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
439843013339	AMP binding site [chemical binding]; other site
439843013340	metal binding site [ion binding]; metal-binding site
439843013341	active site
439843013342	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
439843013343	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
439843013344	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
439843013345	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
439843013346	hypothetical protein; Provisional; Region: PRK05255
439843013347	peptidase PmbA; Provisional; Region: PRK11040
439843013348	cytochrome b562; Provisional; Region: PRK15058
439843013349	PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582
439843013350	conserved hypothetical protein EF_0830/AHA_3911; Region: EF_0830; TIGR03577
439843013351	conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578
439843013352	conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580
439843013353	Domain of unknown function (DUF4310); Region: DUF4310; pfam14187
439843013354	probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583
439843013355	Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307
439843013356	active site
439843013357	uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437
439843013358	conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581
439843013359	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
439843013360	HTH domain; Region: HTH_11; pfam08279
439843013361	Mga helix-turn-helix domain; Region: Mga; pfam05043
439843013362	PRD domain; Region: PRD; pfam00874
439843013363	PRD domain; Region: PRD; pfam00874
439843013364	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
439843013365	active site
439843013366	P-loop; other site
439843013367	phosphorylation site [posttranslational modification]
439843013368	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
439843013369	active site
439843013370	phosphorylation site [posttranslational modification]
439843013371	bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235
439843013372	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
439843013373	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
439843013374	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439843013375	FeS/SAM binding site; other site
439843013376	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
439843013377	ATP cone domain; Region: ATP-cone; pfam03477
439843013378	Class III ribonucleotide reductase; Region: RNR_III; cd01675
439843013379	effector binding site; other site
439843013380	active site
439843013381	Zn binding site [ion binding]; other site
439843013382	glycine loop; other site
439843013383	trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933
439843013384	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
439843013385	Ca binding site [ion binding]; other site
439843013386	active site
439843013387	catalytic site [active]
439843013388	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
439843013389	PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007
439843013390	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
439843013391	active site turn [active]
439843013392	phosphorylation site [posttranslational modification]
439843013393	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
439843013394	trehalose repressor; Provisional; Region: treR; PRK09492
439843013395	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
439843013396	DNA binding site [nucleotide binding]
439843013397	domain linker motif; other site
439843013398	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
439843013399	dimerization interface [polypeptide binding]; other site
439843013400	ligand binding site [chemical binding]; other site
439843013401	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
439843013402	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
439843013403	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
439843013404	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
439843013405	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
439843013406	Soluble P-type ATPase [General function prediction only]; Region: COG4087
439843013407	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
439843013408	Transposase; Region: HTH_Tnp_1; cl17663
439843013409	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
439843013410	homotrimer interaction site [polypeptide binding]; other site
439843013411	putative active site [active]
439843013412	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
439843013413	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
439843013414	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
439843013415	Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540
439843013416	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
439843013417	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
439843013418	Arginine repressor [Transcription]; Region: ArgR; COG1438
439843013419	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
439843013420	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
439843013421	Predicted membrane protein [Function unknown]; Region: COG1288
439843013422	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
439843013423	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
439843013424	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
439843013425	putative substrate binding site [chemical binding]; other site
439843013426	nucleotide binding site [chemical binding]; other site
439843013427	nucleotide binding site [chemical binding]; other site
439843013428	homodimer interface [polypeptide binding]; other site
439843013429	arginine deiminase; Provisional; Region: PRK01388
439843013430	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
439843013431	ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515
439843013432	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
439843013433	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
439843013434	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076
439843013435	RNase E inhibitor protein; Provisional; Region: PRK11191
439843013436	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
439843013437	active site
439843013438	dinuclear metal binding site [ion binding]; other site
439843013439	dimerization interface [polypeptide binding]; other site
439843013440	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
439843013441	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
439843013442	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
439843013443	Coenzyme A binding pocket [chemical binding]; other site
439843013444	Predicted membrane protein [Function unknown]; Region: COG4269
439843013445	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
439843013446	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
439843013447	HIGH motif; other site
439843013448	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
439843013449	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
439843013450	active site
439843013451	KMSKS motif; other site
439843013452	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
439843013453	tRNA binding surface [nucleotide binding]; other site
439843013454	anticodon binding site; other site
439843013455	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
439843013456	DNA polymerase III subunit chi; Validated; Region: PRK05728
439843013457	multifunctional aminopeptidase A; Provisional; Region: PRK00913
439843013458	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
439843013459	interface (dimer of trimers) [polypeptide binding]; other site
439843013460	Substrate-binding/catalytic site; other site
439843013461	Zn-binding sites [ion binding]; other site
439843013462	lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120
439843013463	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
439843013464	lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071
439843013465	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
439843013466	gluconate operon transcriptional regulator; Provisional; Region: PRK14987
439843013467	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
439843013468	DNA binding site [nucleotide binding]
439843013469	domain linker motif; other site
439843013470	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
439843013471	putative dimerization interface [polypeptide binding]; other site
439843013472	putative ligand binding site [chemical binding]; other site
439843013473	gluconate transporter; Region: gntP; TIGR00791
439843013474	fructuronate transporter; Provisional; Region: PRK10034; cl15264
439843013475	gluconate 5-dehydrogenase; Provisional; Region: PRK08085
439843013476	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
439843013477	NADP binding site [chemical binding]; other site
439843013478	homodimer interface [polypeptide binding]; other site
439843013479	active site
439843013480	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
439843013481	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
439843013482	putative NAD(P) binding site [chemical binding]; other site
439843013483	catalytic Zn binding site [ion binding]; other site
439843013484	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
439843013485	ATP-binding site [chemical binding]; other site
439843013486	Gluconate-6-phosphate binding site [chemical binding]; other site
439843013487	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
439843013488	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
439843013489	putative NAD(P) binding site [chemical binding]; other site
439843013490	putative substrate binding site [chemical binding]; other site
439843013491	catalytic Zn binding site [ion binding]; other site
439843013492	structural Zn binding site [ion binding]; other site
439843013493	dimer interface [polypeptide binding]; other site
439843013494	Post-segregation antitoxin CcdA; Region: CcdA; pfam07362
439843013495	CcdB protein; Region: CcdB; pfam01845
439843013496	Part of AAA domain; Region: AAA_19; pfam13245
439843013497	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
439843013498	AAA domain; Region: AAA_12; pfam13087
439843013499	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
439843013500	putative active site [active]
439843013501	catalytic site [active]
439843013502	DNA cytosine methylase; Provisional; Region: PRK10458
439843013503	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
439843013504	cofactor binding site; other site
439843013505	DNA binding site [nucleotide binding]
439843013506	substrate interaction site [chemical binding]; other site
439843013507	N-terminal domain of type IIE restriction endonuclease EcoRII and similar proteins; Region: EcoRII_N; cd10016
439843013508	DNA binding site [nucleotide binding]
439843013509	EcoRII C terminal; Region: EcoRII-C; pfam09019
439843013510	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
439843013511	hypothetical protein; Provisional; Region: PRK12378
439843013512	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439843013513	S-adenosylmethionine binding site [chemical binding]; other site
439843013514	Methyltransferase domain; Region: Methyltransf_31; pfam13847
439843013515	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439843013516	S-adenosylmethionine binding site [chemical binding]; other site
439843013517	hypothetical protein; Provisional; Region: PRK13687
439843013518	Protein of unknown function (DUF1062); Region: DUF1062; cl01786
439843013519	Uncharacterized conserved protein [Function unknown]; Region: COG3439
439843013520	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
439843013521	DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225
439843013522	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
439843013523	DNA-binding site [nucleotide binding]; DNA binding site
439843013524	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
439843013525	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
439843013526	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
439843013527	active site
439843013528	HIGH motif; other site
439843013529	dimer interface [polypeptide binding]; other site
439843013530	KMSKS motif; other site
439843013531	Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion,    and vesicular transport]; Region: Hcp; COG3157
439843013532	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
439843013533	aspartate racemase; Region: asp_race; TIGR00035
439843013534	cell density-dependent motility repressor; Provisional; Region: PRK10082
439843013535	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
439843013536	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
439843013537	dimerization interface [polypeptide binding]; other site
439843013538	isoaspartyl dipeptidase; Provisional; Region: PRK10657
439843013539	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
439843013540	active site
439843013541	hypothetical protein; Provisional; Region: PRK10519
439843013542	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
439843013543	Nucleoside recognition; Region: Gate; pfam07670
439843013544	Protein of unknown function (DUF1228); Region: DUF1228; pfam06779
439843013545	Predicted membrane protein [Function unknown]; Region: COG2733
439843013546	multidrug efflux system protein MdtM; Provisional; Region: PRK15403
439843013547	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
439843013548	putative substrate translocation pore; other site
439843013549	putative transposase; Provisional; Region: PRK09857
439843013550	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
439843013551	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
439843013552	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
439843013553	NAD(P) binding site [chemical binding]; other site
439843013554	catalytic residues [active]
439843013555	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
439843013556	Protein of unknown function DUF91; Region: DUF91; cl00709
439843013557	Uncharacterized conserved protein [Function unknown]; Region: COG3586
439843013558	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
439843013559	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
439843013560	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
439843013561	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439843013562	putative GTP-binding protein YjiA; Provisional; Region: PRK11537
439843013563	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
439843013564	P-loop, Walker A motif; other site
439843013565	Base recognition motif; other site
439843013566	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
439843013567	Uncharacterized small protein [Function unknown]; Region: COG2879
439843013568	carbon starvation protein A; Provisional; Region: PRK15015
439843013569	Carbon starvation protein CstA; Region: CstA; pfam02554
439843013570	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
439843013571	methyl-accepting protein IV; Provisional; Region: PRK09793
439843013572	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
439843013573	dimer interface [polypeptide binding]; other site
439843013574	ligand binding site [chemical binding]; other site
439843013575	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
439843013576	dimerization interface [polypeptide binding]; other site
439843013577	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
439843013578	dimer interface [polypeptide binding]; other site
439843013579	putative CheW interface [polypeptide binding]; other site
439843013580	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
439843013581	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439843013582	Walker A motif; other site
439843013583	ATP binding site [chemical binding]; other site
439843013584	Walker B motif; other site
439843013585	arginine finger; other site
439843013586	Transcriptional antiterminator [Transcription]; Region: COG3933
439843013587	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
439843013588	active pocket/dimerization site; other site
439843013589	active site
439843013590	phosphorylation site [posttranslational modification]
439843013591	PRD domain; Region: PRD; pfam00874
439843013592	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
439843013593	active pocket/dimerization site; other site
439843013594	active site
439843013595	phosphorylation site [posttranslational modification]
439843013596	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
439843013597	active site
439843013598	phosphorylation site [posttranslational modification]
439843013599	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
439843013600	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
439843013601	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
439843013602	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
439843013603	dimer interface [polypeptide binding]; other site
439843013604	active site
439843013605	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
439843013606	dimer interface [polypeptide binding]; other site
439843013607	active site
439843013608	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
439843013609	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
439843013610	putative active site [active]
439843013611	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
439843013612	phosphoglycerol transferase I; Provisional; Region: PRK03776
439843013613	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
439843013614	hypothetical protein; Provisional; Region: PRK11667
439843013615	DNA replication protein DnaC; Validated; Region: PRK07952
439843013616	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
439843013617	Walker A motif; other site
439843013618	ATP binding site [chemical binding]; other site
439843013619	Walker B motif; other site
439843013620	primosomal protein DnaI; Provisional; Region: PRK02854
439843013621	hypothetical protein; Provisional; Region: PRK09917
439843013622	Uncharacterized conserved protein [Function unknown]; Region: COG2966
439843013623	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
439843013624	DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475
439843013625	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
439843013626	DNA binding residues [nucleotide binding]
439843013627	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
439843013628	putative deacylase active site [active]
439843013629	ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647
439843013630	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
439843013631	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
439843013632	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
439843013633	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
439843013634	metal binding site [ion binding]; metal-binding site
439843013635	active site
439843013636	I-site; other site
439843013637	Protein of unknown function (DUF1435); Region: DUF1435; pfam07256
439843013638	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
439843013639	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
439843013640	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
439843013641	S-adenosylmethionine binding site [chemical binding]; other site
439843013642	DNA polymerase III subunit psi; Validated; Region: PRK06856
439843013643	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
439843013644	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
439843013645	Coenzyme A binding pocket [chemical binding]; other site
439843013646	dUMP phosphatase; Provisional; Region: PRK09449
439843013647	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439843013648	motif II; other site
439843013649	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
439843013650	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
439843013651	G1 box; other site
439843013652	putative GEF interaction site [polypeptide binding]; other site
439843013653	GTP/Mg2+ binding site [chemical binding]; other site
439843013654	Switch I region; other site
439843013655	G2 box; other site
439843013656	G3 box; other site
439843013657	Switch II region; other site
439843013658	G4 box; other site
439843013659	G5 box; other site
439843013660	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
439843013661	periplasmic protein; Provisional; Region: PRK10568
439843013662	BON domain; Region: BON; pfam04972
439843013663	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
439843013664	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
439843013665	active site
439843013666	nucleophile elbow; other site
439843013667	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
439843013668	active site
439843013669	glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041
439843013670	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
439843013671	FeS/SAM binding site; other site
439843013672	hypothetical protein; Provisional; Region: PRK10977
439843013673	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
439843013674	intersubunit interface [polypeptide binding]; other site
439843013675	active site
439843013676	catalytic residue [active]
439843013677	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
439843013678	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
439843013679	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
439843013680	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
439843013681	phosphopentomutase; Provisional; Region: PRK05362
439843013682	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
439843013683	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
439843013684	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
439843013685	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
439843013686	lipoate-protein ligase A; Provisional; Region: lplA; PRK03822
439843013687	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
439843013688	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
439843013689	hypothetical protein; Provisional; Region: PRK11246
439843013690	phosphoserine phosphatase; Provisional; Region: serB; PRK11133
439843013691	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
439843013692	motif II; other site
439843013693	DNA repair protein RadA; Region: sms; TIGR00416
439843013694	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
439843013695	Walker A motif/ATP binding site; other site
439843013696	ATP binding site [chemical binding]; other site
439843013697	Walker B motif; other site
439843013698	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
439843013699	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
439843013700	non-specific DNA binding site [nucleotide binding]; other site
439843013701	salt bridge; other site
439843013702	bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099
439843013703	sequence-specific DNA binding site [nucleotide binding]; other site
439843013704	Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167
439843013705	active site
439843013706	(T/H)XGH motif; other site
439843013707	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
439843013708	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
439843013709	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
439843013710	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
439843013711	ABC transporter; Region: ABC_tran_2; pfam12848
439843013712	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
439843013713	lytic murein transglycosylase; Provisional; Region: PRK11619
439843013714	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
439843013715	N-acetyl-D-glucosamine binding site [chemical binding]; other site
439843013716	catalytic residue [active]
439843013717	Trp operon repressor; Provisional; Region: PRK01381
439843013718	inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074
439843013719	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
439843013720	catalytic core [active]
439843013721	right oriC-binding transcriptional activator; Provisional; Region: PRK15121
439843013722	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
439843013723	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
439843013724	hypothetical protein; Provisional; Region: PRK10756
439843013725	CreA protein; Region: CreA; pfam05981
439843013726	DNA-binding response regulator CreB; Provisional; Region: PRK11083
439843013727	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843013728	active site
439843013729	phosphorylation site [posttranslational modification]
439843013730	intermolecular recognition site; other site
439843013731	dimerization interface [polypeptide binding]; other site
439843013732	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
439843013733	DNA binding site [nucleotide binding]
439843013734	sensory histidine kinase CreC; Provisional; Region: PRK11100
439843013735	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
439843013736	dimerization interface [polypeptide binding]; other site
439843013737	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
439843013738	dimer interface [polypeptide binding]; other site
439843013739	phosphorylation site [posttranslational modification]
439843013740	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
439843013741	ATP binding site [chemical binding]; other site
439843013742	Mg2+ binding site [ion binding]; other site
439843013743	G-X-G motif; other site
439843013744	Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452
439843013745	putative major fimbrial protein SthE; Provisional; Region: PRK15292
439843013746	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
439843013747	putative fimbrial protein SthD; Provisional; Region: PRK15293
439843013748	putative fimbrial outer membrane usher protein SthC; Provisional; Region: PRK15294
439843013749	PapC N-terminal domain; Region: PapC_N; pfam13954
439843013750	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
439843013751	PapC C-terminal domain; Region: PapC_C; pfam13953
439843013752	fimbrial assembly chaperone SthB; Provisional; Region: PRK15295
439843013753	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
439843013754	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
439843013755	putative fimbrial protein SthA; Provisional; Region: PRK15296
439843013756	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832
439843013757	Helix-turn-helix domain; Region: HTH_36; pfam13730
439843013758	two-component response regulator; Provisional; Region: PRK11173
439843013759	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
439843013760	active site
439843013761	phosphorylation site [posttranslational modification]
439843013762	intermolecular recognition site; other site
439843013763	dimerization interface [polypeptide binding]; other site
439843013764	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
439843013765	DNA binding site [nucleotide binding]
439843013766	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
439843013767	putative RNA methyltransferase; Provisional; Region: PRK10433