-- dump date 20140620_054549 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1064551000001 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 1064551000002 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1064551000003 putative catalytic residues [active] 1064551000004 putative nucleotide binding site [chemical binding]; other site 1064551000005 putative aspartate binding site [chemical binding]; other site 1064551000006 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 1064551000007 dimer interface [polypeptide binding]; other site 1064551000008 putative threonine allosteric regulatory site; other site 1064551000009 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 1064551000010 putative threonine allosteric regulatory site; other site 1064551000011 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1064551000012 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1064551000013 homoserine kinase; Provisional; Region: PRK01212 1064551000014 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1064551000015 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1064551000016 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1064551000017 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551000018 catalytic residue [active] 1064551000019 hypothetical protein; Validated; Region: PRK02101 1064551000020 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1064551000021 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1064551000022 transaldolase-like protein; Provisional; Region: PTZ00411 1064551000023 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1064551000024 active site 1064551000025 dimer interface [polypeptide binding]; other site 1064551000026 catalytic residue [active] 1064551000027 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1064551000028 MPT binding site; other site 1064551000029 trimer interface [polypeptide binding]; other site 1064551000030 hypothetical protein; Provisional; Region: PRK10659 1064551000031 hypothetical protein; Provisional; Region: PRK10236 1064551000032 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 1064551000033 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 1064551000034 hypothetical protein; Provisional; Region: PRK10154 1064551000035 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1064551000036 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1064551000037 nucleotide binding site [chemical binding]; other site 1064551000038 chaperone protein DnaJ; Provisional; Region: PRK10767 1064551000039 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1064551000040 HSP70 interaction site [polypeptide binding]; other site 1064551000041 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1064551000042 substrate binding site [polypeptide binding]; other site 1064551000043 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1064551000044 Zn binding sites [ion binding]; other site 1064551000045 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1064551000046 dimer interface [polypeptide binding]; other site 1064551000047 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064551000048 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551000049 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1064551000050 substrate binding pocket [chemical binding]; other site 1064551000051 dimerization interface [polypeptide binding]; other site 1064551000052 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 1064551000053 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 1064551000054 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 1064551000055 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1064551000056 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 1064551000057 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1064551000058 active site 1064551000059 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 1064551000060 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1064551000061 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1064551000062 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1064551000063 Helix-turn-helix domain; Region: HTH_36; pfam13730 1064551000064 fimbrial protein BcfA; Provisional; Region: PRK15187 1064551000065 fimbrial chaperone protein BcfB; Provisional; Region: PRK15188 1064551000066 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1064551000067 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1064551000068 outer membrane usher protein; Provisional; Region: PRK15193 1064551000069 PapC N-terminal domain; Region: PapC_N; pfam13954 1064551000070 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1064551000071 PapC C-terminal domain; Region: PapC_C; pfam13953 1064551000072 fimbrial protein BcfD; Provisional; Region: PRK15189 1064551000073 fimbrial protein BcfE; Provisional; Region: PRK15190 1064551000074 Fimbrial protein; Region: Fimbrial; cl01416 1064551000075 fimbrial chaperone BcfG; Provisional; Region: PRK15192 1064551000076 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1064551000077 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1064551000078 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 1064551000079 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1064551000080 catalytic residues [active] 1064551000081 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1064551000082 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064551000083 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551000084 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1064551000085 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1064551000086 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 1064551000087 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1064551000088 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1064551000089 active site 1064551000090 metal binding site [ion binding]; metal-binding site 1064551000091 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1064551000092 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502 1064551000093 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1064551000094 Sulfatase; Region: Sulfatase; pfam00884 1064551000095 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1064551000096 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064551000097 FeS/SAM binding site; other site 1064551000098 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1064551000099 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1064551000100 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 1064551000101 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 1064551000102 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 1064551000103 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551000104 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 1064551000105 putative dimerization interface [polypeptide binding]; other site 1064551000106 putative alpha-glucosidase; Provisional; Region: PRK10658 1064551000107 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1064551000108 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 1064551000109 putative active site [active] 1064551000110 putative catalytic site [active] 1064551000111 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1064551000112 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1064551000113 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1064551000114 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1064551000115 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1064551000116 active site 1064551000117 Riboflavin kinase; Region: Flavokinase; smart00904 1064551000118 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1064551000119 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1064551000120 active site 1064551000121 HIGH motif; other site 1064551000122 nucleotide binding site [chemical binding]; other site 1064551000123 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1064551000124 active site 1064551000125 KMSKS motif; other site 1064551000126 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1064551000127 tRNA binding surface [nucleotide binding]; other site 1064551000128 anticodon binding site; other site 1064551000129 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1064551000130 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1064551000131 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1064551000132 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1064551000133 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1064551000134 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1064551000135 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1064551000136 active site 1064551000137 tetramer interface [polypeptide binding]; other site 1064551000138 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1064551000139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064551000140 active site 1064551000141 phosphorylation site [posttranslational modification] 1064551000142 intermolecular recognition site; other site 1064551000143 dimerization interface [polypeptide binding]; other site 1064551000144 Transcriptional regulator; Region: CitT; pfam12431 1064551000145 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1064551000146 PAS domain; Region: PAS; smart00091 1064551000147 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064551000148 ATP binding site [chemical binding]; other site 1064551000149 Mg2+ binding site [ion binding]; other site 1064551000150 G-X-G motif; other site 1064551000151 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 1064551000152 oxaloacetate decarboxylase; Provisional; Region: PRK14040 1064551000153 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1064551000154 active site 1064551000155 catalytic residues [active] 1064551000156 metal binding site [ion binding]; metal-binding site 1064551000157 homodimer binding site [polypeptide binding]; other site 1064551000158 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1064551000159 carboxyltransferase (CT) interaction site; other site 1064551000160 biotinylation site [posttranslational modification]; other site 1064551000161 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 1064551000162 Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493 1064551000163 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 1064551000164 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1064551000165 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 1064551000166 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1064551000167 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 1064551000168 triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125 1064551000169 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 1064551000170 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1064551000171 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1064551000172 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1064551000173 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1064551000174 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1064551000175 catalytic site [active] 1064551000176 subunit interface [polypeptide binding]; other site 1064551000177 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1064551000178 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1064551000179 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1064551000180 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1064551000181 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1064551000182 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1064551000183 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1064551000184 IMP binding site; other site 1064551000185 dimer interface [polypeptide binding]; other site 1064551000186 interdomain contacts; other site 1064551000187 partial ornithine binding site; other site 1064551000188 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 1064551000189 carnitine operon protein CaiE; Provisional; Region: PRK13627 1064551000190 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 1064551000191 putative trimer interface [polypeptide binding]; other site 1064551000192 putative metal binding site [ion binding]; other site 1064551000193 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 1064551000194 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1064551000195 substrate binding site [chemical binding]; other site 1064551000196 oxyanion hole (OAH) forming residues; other site 1064551000197 trimer interface [polypeptide binding]; other site 1064551000198 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 1064551000199 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 1064551000200 acyl-activating enzyme (AAE) consensus motif; other site 1064551000201 putative AMP binding site [chemical binding]; other site 1064551000202 putative active site [active] 1064551000203 putative CoA binding site [chemical binding]; other site 1064551000204 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 1064551000205 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1064551000206 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 1064551000207 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1064551000208 active site 1064551000209 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 1064551000210 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1064551000211 Ligand binding site [chemical binding]; other site 1064551000212 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1064551000213 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 1064551000214 Electron transfer flavoprotein domain; Region: ETF; smart00893 1064551000215 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1064551000216 putative oxidoreductase FixC; Provisional; Region: PRK10157 1064551000217 ferredoxin-like protein FixX; Provisional; Region: PRK15449 1064551000218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551000219 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1064551000220 putative substrate translocation pore; other site 1064551000221 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1064551000222 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1064551000223 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1064551000224 Sulfatase; Region: Sulfatase; cl17466 1064551000225 Sulfatase; Region: Sulfatase; cl17466 1064551000226 Sulfatase; Region: Sulfatase; cl17466 1064551000227 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 1064551000228 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 1064551000229 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1064551000230 TrkA-N domain; Region: TrkA_N; pfam02254 1064551000231 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1064551000232 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1064551000233 folate binding site [chemical binding]; other site 1064551000234 NADP+ binding site [chemical binding]; other site 1064551000235 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 1064551000236 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1064551000237 active site 1064551000238 metal binding site [ion binding]; metal-binding site 1064551000239 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1064551000240 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1064551000241 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1064551000242 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1064551000243 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1064551000244 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1064551000245 SurA N-terminal domain; Region: SurA_N; pfam09312 1064551000246 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1064551000247 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1064551000248 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 1064551000249 OstA-like protein; Region: OstA; pfam03968 1064551000250 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1064551000251 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 1064551000252 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1064551000253 putative metal binding site [ion binding]; other site 1064551000254 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1064551000255 HSP70 interaction site [polypeptide binding]; other site 1064551000256 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1064551000257 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1064551000258 active site 1064551000259 ATP-dependent helicase HepA; Validated; Region: PRK04914 1064551000260 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1064551000261 ATP binding site [chemical binding]; other site 1064551000262 putative Mg++ binding site [ion binding]; other site 1064551000263 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1064551000264 nucleotide binding region [chemical binding]; other site 1064551000265 ATP-binding site [chemical binding]; other site 1064551000266 DNA polymerase II; Reviewed; Region: PRK05762 1064551000267 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 1064551000268 active site 1064551000269 catalytic site [active] 1064551000270 substrate binding site [chemical binding]; other site 1064551000271 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 1064551000272 active site 1064551000273 metal-binding site 1064551000274 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1064551000275 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1064551000276 putative active site [active] 1064551000277 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1064551000278 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1064551000279 intersubunit interface [polypeptide binding]; other site 1064551000280 active site 1064551000281 Zn2+ binding site [ion binding]; other site 1064551000282 L-arabinose isomerase; Provisional; Region: PRK02929 1064551000283 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1064551000284 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1064551000285 trimer interface [polypeptide binding]; other site 1064551000286 putative substrate binding site [chemical binding]; other site 1064551000287 putative metal binding site [ion binding]; other site 1064551000288 ribulokinase; Provisional; Region: PRK04123 1064551000289 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1064551000290 N- and C-terminal domain interface [polypeptide binding]; other site 1064551000291 active site 1064551000292 MgATP binding site [chemical binding]; other site 1064551000293 catalytic site [active] 1064551000294 metal binding site [ion binding]; metal-binding site 1064551000295 carbohydrate binding site [chemical binding]; other site 1064551000296 homodimer interface [polypeptide binding]; other site 1064551000297 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 1064551000298 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1064551000299 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064551000300 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064551000301 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1064551000302 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1064551000303 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 1064551000304 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 1064551000305 Walker A/P-loop; other site 1064551000306 ATP binding site [chemical binding]; other site 1064551000307 Q-loop/lid; other site 1064551000308 ABC transporter signature motif; other site 1064551000309 Walker B; other site 1064551000310 D-loop; other site 1064551000311 H-loop/switch region; other site 1064551000312 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 1064551000313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551000314 dimer interface [polypeptide binding]; other site 1064551000315 conserved gate region; other site 1064551000316 putative PBP binding loops; other site 1064551000317 ABC-ATPase subunit interface; other site 1064551000318 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551000319 dimer interface [polypeptide binding]; other site 1064551000320 conserved gate region; other site 1064551000321 putative PBP binding loops; other site 1064551000322 ABC-ATPase subunit interface; other site 1064551000323 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 1064551000324 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1064551000325 transcriptional regulator SgrR; Provisional; Region: PRK13626 1064551000326 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1064551000327 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1064551000328 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1064551000329 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1064551000330 substrate binding site [chemical binding]; other site 1064551000331 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1064551000332 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1064551000333 substrate binding site [chemical binding]; other site 1064551000334 ligand binding site [chemical binding]; other site 1064551000335 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1064551000336 tartrate dehydrogenase; Region: TTC; TIGR02089 1064551000337 2-isopropylmalate synthase; Validated; Region: PRK00915 1064551000338 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1064551000339 active site 1064551000340 catalytic residues [active] 1064551000341 metal binding site [ion binding]; metal-binding site 1064551000342 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1064551000343 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1064551000344 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551000345 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 1064551000346 putative substrate binding pocket [chemical binding]; other site 1064551000347 putative dimerization interface [polypeptide binding]; other site 1064551000348 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 1064551000349 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1064551000350 PYR/PP interface [polypeptide binding]; other site 1064551000351 dimer interface [polypeptide binding]; other site 1064551000352 TPP binding site [chemical binding]; other site 1064551000353 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1064551000354 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1064551000355 TPP-binding site [chemical binding]; other site 1064551000356 dimer interface [polypeptide binding]; other site 1064551000357 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1064551000358 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1064551000359 putative valine binding site [chemical binding]; other site 1064551000360 dimer interface [polypeptide binding]; other site 1064551000361 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1064551000362 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 1064551000363 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1064551000364 DNA binding site [nucleotide binding] 1064551000365 domain linker motif; other site 1064551000366 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1064551000367 dimerization interface [polypeptide binding]; other site 1064551000368 ligand binding site [chemical binding]; other site 1064551000369 mraZ protein; Region: TIGR00242 1064551000370 MraZ protein; Region: MraZ; pfam02381 1064551000371 MraZ protein; Region: MraZ; pfam02381 1064551000372 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 1064551000373 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1064551000374 cell division protein FtsL; Provisional; Region: PRK10772 1064551000375 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1064551000376 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1064551000377 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1064551000378 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1064551000379 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1064551000380 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1064551000381 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1064551000382 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 1064551000383 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1064551000384 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1064551000385 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1064551000386 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1064551000387 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1064551000388 Mg++ binding site [ion binding]; other site 1064551000389 putative catalytic motif [active] 1064551000390 putative substrate binding site [chemical binding]; other site 1064551000391 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 1064551000392 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1064551000393 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1064551000394 cell division protein FtsW; Provisional; Region: PRK10774 1064551000395 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1064551000396 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1064551000397 active site 1064551000398 homodimer interface [polypeptide binding]; other site 1064551000399 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1064551000400 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1064551000401 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1064551000402 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1064551000403 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1064551000404 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1064551000405 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1064551000406 cell division protein FtsQ; Provisional; Region: PRK10775 1064551000407 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1064551000408 Cell division protein FtsQ; Region: FtsQ; pfam03799 1064551000409 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 1064551000410 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1064551000411 Cell division protein FtsA; Region: FtsA; pfam14450 1064551000412 cell division protein FtsZ; Validated; Region: PRK09330 1064551000413 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1064551000414 nucleotide binding site [chemical binding]; other site 1064551000415 SulA interaction site; other site 1064551000416 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 1064551000417 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1064551000418 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1064551000419 SecA regulator SecM; Provisional; Region: PRK02943 1064551000420 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1064551000421 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1064551000422 SEC-C motif; Region: SEC-C; pfam02810 1064551000423 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1064551000424 active site 1064551000425 8-oxo-dGMP binding site [chemical binding]; other site 1064551000426 nudix motif; other site 1064551000427 metal binding site [ion binding]; metal-binding site 1064551000428 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1064551000429 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1064551000430 active site 1064551000431 catalytic tetrad [active] 1064551000432 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064551000433 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551000434 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1064551000435 putative effector binding pocket; other site 1064551000436 putative dimerization interface [polypeptide binding]; other site 1064551000437 DNA gyrase inhibitor; Reviewed; Region: PRK00418 1064551000438 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 1064551000439 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1064551000440 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1064551000441 CoA-binding site [chemical binding]; other site 1064551000442 ATP-binding [chemical binding]; other site 1064551000443 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 1064551000444 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1064551000445 active site 1064551000446 type IV pilin biogenesis protein; Provisional; Region: PRK10573 1064551000447 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1064551000448 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1064551000449 hypothetical protein; Provisional; Region: PRK10436 1064551000450 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1064551000451 Walker A motif; other site 1064551000452 ATP binding site [chemical binding]; other site 1064551000453 Walker B motif; other site 1064551000454 putative major pilin subunit; Provisional; Region: PRK10574 1064551000455 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1064551000456 Pilin (bacterial filament); Region: Pilin; pfam00114 1064551000457 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 1064551000458 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1064551000459 dimerization interface [polypeptide binding]; other site 1064551000460 active site 1064551000461 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1064551000462 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1064551000463 amidase catalytic site [active] 1064551000464 Zn binding residues [ion binding]; other site 1064551000465 substrate binding site [chemical binding]; other site 1064551000466 regulatory protein AmpE; Provisional; Region: PRK10987 1064551000467 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 1064551000468 active site 1064551000469 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1064551000470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551000471 putative substrate translocation pore; other site 1064551000472 aromatic amino acid transporter; Provisional; Region: PRK10238 1064551000473 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 1064551000474 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064551000475 DNA-binding site [nucleotide binding]; DNA binding site 1064551000476 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1064551000477 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1064551000478 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1064551000479 dimer interface [polypeptide binding]; other site 1064551000480 TPP-binding site [chemical binding]; other site 1064551000481 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 1064551000482 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1064551000483 E3 interaction surface; other site 1064551000484 lipoyl attachment site [posttranslational modification]; other site 1064551000485 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1064551000486 E3 interaction surface; other site 1064551000487 lipoyl attachment site [posttranslational modification]; other site 1064551000488 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1064551000489 E3 interaction surface; other site 1064551000490 lipoyl attachment site [posttranslational modification]; other site 1064551000491 e3 binding domain; Region: E3_binding; pfam02817 1064551000492 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1064551000493 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1064551000494 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1064551000495 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1064551000496 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1064551000497 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 1064551000498 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 1064551000499 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1064551000500 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1064551000501 substrate binding site [chemical binding]; other site 1064551000502 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1064551000503 substrate binding site [chemical binding]; other site 1064551000504 ligand binding site [chemical binding]; other site 1064551000505 Domain of unknown function (DUF4424); Region: DUF4424; pfam14415 1064551000506 Domain of unknown function (DUF4424); Region: DUF4424; pfam14415 1064551000507 aconitate hydratase 2; Provisional; Region: PLN00094 1064551000508 putative inner membrane protein; Provisional; Region: PRK09823 1064551000509 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1064551000510 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1064551000511 active site 1064551000512 hypothetical protein; Provisional; Region: PRK05248 1064551000513 2-keto-3-deoxygluconate permease; Provisional; Region: PRK12460 1064551000514 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1064551000515 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1064551000516 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 1064551000517 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1064551000518 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1064551000519 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1064551000520 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 1064551000521 spermidine synthase; Provisional; Region: PRK00811 1064551000522 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064551000523 S-adenosylmethionine binding site [chemical binding]; other site 1064551000524 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 1064551000525 multicopper oxidase; Provisional; Region: PRK10965 1064551000526 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1064551000527 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1064551000528 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1064551000529 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1064551000530 Trp docking motif [polypeptide binding]; other site 1064551000531 putative active site [active] 1064551000532 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1064551000533 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1064551000534 active site 1064551000535 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1064551000536 active site clefts [active] 1064551000537 zinc binding site [ion binding]; other site 1064551000538 dimer interface [polypeptide binding]; other site 1064551000539 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1064551000540 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1064551000541 Walker A/P-loop; other site 1064551000542 ATP binding site [chemical binding]; other site 1064551000543 Q-loop/lid; other site 1064551000544 ABC transporter signature motif; other site 1064551000545 Walker B; other site 1064551000546 D-loop; other site 1064551000547 H-loop/switch region; other site 1064551000548 inner membrane transport permease; Provisional; Region: PRK15066 1064551000549 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1064551000550 putative fimbrial protein StiH; Provisional; Region: PRK15297 1064551000551 fimbrial outer membrane usher protein StiC; Provisional; Region: PRK15298 1064551000552 PapC N-terminal domain; Region: PapC_N; pfam13954 1064551000553 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1064551000554 PapC C-terminal domain; Region: PapC_C; pfam13953 1064551000555 fimbrial chaperone protein StiB; Provisional; Region: PRK15299 1064551000556 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1064551000557 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1064551000558 fimbrial protein StiA; Provisional; Region: PRK15300 1064551000559 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1064551000560 active pocket/dimerization site; other site 1064551000561 active site 1064551000562 phosphorylation site [posttranslational modification] 1064551000563 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 1064551000564 putative active site [active] 1064551000565 putative metal binding site [ion binding]; other site 1064551000566 putative fimbrial protein StkG; Provisional; Region: PRK15305 1064551000567 putative fimbrial protein StaF; Provisional; Region: PRK15262 1064551000568 putative fimbrial protein StaE; Provisional; Region: PRK15263 1064551000569 putative fimbrial protein StkD; Provisional; Region: PRK15306 1064551000570 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 1064551000571 PapC N-terminal domain; Region: PapC_N; pfam13954 1064551000572 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1064551000573 PapC C-terminal domain; Region: PapC_C; pfam13953 1064551000574 fimbrial assembly chaperone StbE; Provisional; Region: PRK15246 1064551000575 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1064551000576 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1064551000577 major fimbrial protein StkA; Provisional; Region: PRK15307 1064551000578 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1064551000579 tetramerization interface [polypeptide binding]; other site 1064551000580 active site 1064551000581 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1064551000582 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1064551000583 active site 1064551000584 ATP-binding site [chemical binding]; other site 1064551000585 pantoate-binding site; other site 1064551000586 HXXH motif; other site 1064551000587 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1064551000588 oligomerization interface [polypeptide binding]; other site 1064551000589 active site 1064551000590 metal binding site [ion binding]; metal-binding site 1064551000591 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1064551000592 catalytic center binding site [active] 1064551000593 ATP binding site [chemical binding]; other site 1064551000594 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 1064551000595 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1064551000596 active site 1064551000597 NTP binding site [chemical binding]; other site 1064551000598 metal binding triad [ion binding]; metal-binding site 1064551000599 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1064551000600 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1064551000601 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 1064551000602 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1064551000603 active site 1064551000604 nucleotide binding site [chemical binding]; other site 1064551000605 HIGH motif; other site 1064551000606 KMSKS motif; other site 1064551000607 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 1064551000608 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1064551000609 2'-5' RNA ligase; Provisional; Region: PRK15124 1064551000610 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1064551000611 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1064551000612 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 1064551000613 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1064551000614 ATP binding site [chemical binding]; other site 1064551000615 putative Mg++ binding site [ion binding]; other site 1064551000616 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1064551000617 nucleotide binding region [chemical binding]; other site 1064551000618 ATP-binding site [chemical binding]; other site 1064551000619 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1064551000620 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 1064551000621 Transglycosylase; Region: Transgly; pfam00912 1064551000622 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1064551000623 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1064551000624 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1064551000625 N-terminal plug; other site 1064551000626 ligand-binding site [chemical binding]; other site 1064551000627 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 1064551000628 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1064551000629 Walker A/P-loop; other site 1064551000630 ATP binding site [chemical binding]; other site 1064551000631 Q-loop/lid; other site 1064551000632 ABC transporter signature motif; other site 1064551000633 Walker B; other site 1064551000634 D-loop; other site 1064551000635 H-loop/switch region; other site 1064551000636 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1064551000637 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1064551000638 siderophore binding site; other site 1064551000639 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1064551000640 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1064551000641 ABC-ATPase subunit interface; other site 1064551000642 dimer interface [polypeptide binding]; other site 1064551000643 putative PBP binding regions; other site 1064551000644 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1064551000645 ABC-ATPase subunit interface; other site 1064551000646 dimer interface [polypeptide binding]; other site 1064551000647 putative PBP binding regions; other site 1064551000648 putative fimbrial subunit StfA; Provisional; Region: PRK15283 1064551000649 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 1064551000650 PapC N-terminal domain; Region: PapC_N; pfam13954 1064551000651 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1064551000652 PapC C-terminal domain; Region: PapC_C; pfam13953 1064551000653 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 1064551000654 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1064551000655 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1064551000656 putative minor fimbrial subunit StfE; Provisional; Region: PRK15286 1064551000657 putative minor fimbrial subunit StfF; Provisional; Region: PRK15287 1064551000658 putative minor fimbrial subunit StfG; Provisional; Region: PRK15288 1064551000659 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 1064551000660 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1064551000661 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1064551000662 inhibitor-cofactor binding pocket; inhibition site 1064551000663 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551000664 catalytic residue [active] 1064551000665 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1064551000666 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1064551000667 Cl- selectivity filter; other site 1064551000668 Cl- binding residues [ion binding]; other site 1064551000669 pore gating glutamate residue; other site 1064551000670 dimer interface [polypeptide binding]; other site 1064551000671 H+/Cl- coupling transport residue; other site 1064551000672 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1064551000673 hypothetical protein; Provisional; Region: PRK10578 1064551000674 UPF0126 domain; Region: UPF0126; pfam03458 1064551000675 UPF0126 domain; Region: UPF0126; pfam03458 1064551000676 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 1064551000677 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1064551000678 cobalamin binding residues [chemical binding]; other site 1064551000679 putative BtuC binding residues; other site 1064551000680 dimer interface [polypeptide binding]; other site 1064551000681 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1064551000682 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1064551000683 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 1064551000684 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1064551000685 Zn2+ binding site [ion binding]; other site 1064551000686 Mg2+ binding site [ion binding]; other site 1064551000687 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1064551000688 serine endoprotease; Provisional; Region: PRK10942 1064551000689 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1064551000690 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1064551000691 protein binding site [polypeptide binding]; other site 1064551000692 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1064551000693 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 1064551000694 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1064551000695 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1064551000696 hypothetical protein; Provisional; Region: PRK13677 1064551000697 shikimate transporter; Provisional; Region: PRK09952 1064551000698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551000699 putative substrate translocation pore; other site 1064551000700 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1064551000701 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1064551000702 trimer interface [polypeptide binding]; other site 1064551000703 active site 1064551000704 substrate binding site [chemical binding]; other site 1064551000705 CoA binding site [chemical binding]; other site 1064551000706 PII uridylyl-transferase; Provisional; Region: PRK05007 1064551000707 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1064551000708 metal binding triad; other site 1064551000709 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1064551000710 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1064551000711 Zn2+ binding site [ion binding]; other site 1064551000712 Mg2+ binding site [ion binding]; other site 1064551000713 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1064551000714 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1064551000715 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1064551000716 active site 1064551000717 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1064551000718 rRNA interaction site [nucleotide binding]; other site 1064551000719 S8 interaction site; other site 1064551000720 putative laminin-1 binding site; other site 1064551000721 elongation factor Ts; Provisional; Region: tsf; PRK09377 1064551000722 UBA/TS-N domain; Region: UBA; pfam00627 1064551000723 Elongation factor TS; Region: EF_TS; pfam00889 1064551000724 Elongation factor TS; Region: EF_TS; pfam00889 1064551000725 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1064551000726 putative nucleotide binding site [chemical binding]; other site 1064551000727 uridine monophosphate binding site [chemical binding]; other site 1064551000728 homohexameric interface [polypeptide binding]; other site 1064551000729 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1064551000730 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1064551000731 hinge region; other site 1064551000732 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1064551000733 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1064551000734 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1064551000735 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1064551000736 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1064551000737 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1064551000738 catalytic residue [active] 1064551000739 putative FPP diphosphate binding site; other site 1064551000740 putative FPP binding hydrophobic cleft; other site 1064551000741 dimer interface [polypeptide binding]; other site 1064551000742 putative IPP diphosphate binding site; other site 1064551000743 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 1064551000744 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1064551000745 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1064551000746 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1064551000747 active site 1064551000748 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1064551000749 protein binding site [polypeptide binding]; other site 1064551000750 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1064551000751 protein binding site [polypeptide binding]; other site 1064551000752 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1064551000753 putative substrate binding region [chemical binding]; other site 1064551000754 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 1064551000755 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1064551000756 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1064551000757 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1064551000758 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1064551000759 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1064551000760 Surface antigen; Region: Bac_surface_Ag; pfam01103 1064551000761 periplasmic chaperone; Provisional; Region: PRK10780 1064551000762 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1064551000763 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1064551000764 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1064551000765 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1064551000766 trimer interface [polypeptide binding]; other site 1064551000767 active site 1064551000768 UDP-GlcNAc binding site [chemical binding]; other site 1064551000769 lipid binding site [chemical binding]; lipid-binding site 1064551000770 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1064551000771 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1064551000772 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1064551000773 active site 1064551000774 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1064551000775 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1064551000776 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1064551000777 RNA/DNA hybrid binding site [nucleotide binding]; other site 1064551000778 active site 1064551000779 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1064551000780 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1064551000781 putative active site [active] 1064551000782 putative PHP Thumb interface [polypeptide binding]; other site 1064551000783 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1064551000784 generic binding surface II; other site 1064551000785 generic binding surface I; other site 1064551000786 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1064551000787 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1064551000788 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 1064551000789 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 1064551000790 putative sugar binding site [chemical binding]; other site 1064551000791 catalytic residues [active] 1064551000792 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 1064551000793 lysine decarboxylase LdcC; Provisional; Region: PRK15399 1064551000794 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1064551000795 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1064551000796 homodimer interface [polypeptide binding]; other site 1064551000797 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551000798 catalytic residue [active] 1064551000799 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1064551000800 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1064551000801 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1064551000802 putative metal binding site [ion binding]; other site 1064551000803 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 1064551000804 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1064551000805 Ligand Binding Site [chemical binding]; other site 1064551000806 TilS substrate binding domain; Region: TilS; pfam09179 1064551000807 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 1064551000808 Rho-binding antiterminator; Provisional; Region: PRK11625 1064551000809 hypothetical protein; Provisional; Region: PRK04964 1064551000810 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 1064551000811 hypothetical protein; Provisional; Region: PRK09256 1064551000812 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1064551000813 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 1064551000814 NlpE N-terminal domain; Region: NlpE; pfam04170 1064551000815 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1064551000816 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1064551000817 dimer interface [polypeptide binding]; other site 1064551000818 motif 1; other site 1064551000819 active site 1064551000820 motif 2; other site 1064551000821 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1064551000822 putative deacylase active site [active] 1064551000823 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1064551000824 active site 1064551000825 motif 3; other site 1064551000826 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1064551000827 anticodon binding site; other site 1064551000828 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1064551000829 homodimer interaction site [polypeptide binding]; other site 1064551000830 cofactor binding site; other site 1064551000831 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 1064551000832 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 1064551000833 lipoprotein, YaeC family; Region: TIGR00363 1064551000834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551000835 dimer interface [polypeptide binding]; other site 1064551000836 conserved gate region; other site 1064551000837 ABC-ATPase subunit interface; other site 1064551000838 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1064551000839 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1064551000840 Walker A/P-loop; other site 1064551000841 ATP binding site [chemical binding]; other site 1064551000842 Q-loop/lid; other site 1064551000843 ABC transporter signature motif; other site 1064551000844 Walker B; other site 1064551000845 D-loop; other site 1064551000846 H-loop/switch region; other site 1064551000847 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1064551000848 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 1064551000849 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064551000850 active site 1064551000851 motif I; other site 1064551000852 motif II; other site 1064551000853 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1064551000854 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1064551000855 active site 1064551000856 catalytic tetrad [active] 1064551000857 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064551000858 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551000859 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 1064551000860 putative effector binding pocket; other site 1064551000861 dimerization interface [polypeptide binding]; other site 1064551000862 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1064551000863 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551000864 putative substrate translocation pore; other site 1064551000865 hypothetical protein; Provisional; Region: PRK05421 1064551000866 putative catalytic site [active] 1064551000867 putative metal binding site [ion binding]; other site 1064551000868 putative phosphate binding site [ion binding]; other site 1064551000869 putative catalytic site [active] 1064551000870 putative phosphate binding site [ion binding]; other site 1064551000871 putative metal binding site [ion binding]; other site 1064551000872 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1064551000873 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064551000874 S-adenosylmethionine binding site [chemical binding]; other site 1064551000875 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 1064551000876 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1064551000877 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1064551000878 catalytic residue [active] 1064551000879 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1064551000880 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1064551000881 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 1064551000882 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064551000883 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1064551000884 RNA/DNA hybrid binding site [nucleotide binding]; other site 1064551000885 active site 1064551000886 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1064551000887 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1064551000888 active site 1064551000889 catalytic site [active] 1064551000890 substrate binding site [chemical binding]; other site 1064551000891 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 1064551000892 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1064551000893 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3520 1064551000894 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1064551000895 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1064551000896 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 1064551000897 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 1064551000898 ImpE protein; Region: ImpE; pfam07024 1064551000899 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1064551000900 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064551000901 Walker A motif; other site 1064551000902 ATP binding site [chemical binding]; other site 1064551000903 Walker B motif; other site 1064551000904 arginine finger; other site 1064551000905 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064551000906 Walker A motif; other site 1064551000907 ATP binding site [chemical binding]; other site 1064551000908 Walker B motif; other site 1064551000909 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1064551000910 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 1064551000911 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 1064551000912 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1064551000913 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 1064551000914 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 1064551000915 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 1064551000916 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3521 1064551000917 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 1064551000918 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1064551000919 hypothetical protein; Provisional; Region: PRK08126 1064551000920 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 1064551000921 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1064551000922 ligand binding site [chemical binding]; other site 1064551000923 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 1064551000924 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1064551000925 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1064551000926 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 1064551000927 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1064551000928 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4893 1064551000929 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 1064551000930 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1064551000931 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1064551000932 Uncharacterized conserved protein [Function unknown]; Region: COG5435 1064551000933 PAAR motif; Region: PAAR_motif; pfam05488 1064551000934 RHS Repeat; Region: RHS_repeat; pfam05593 1064551000935 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1064551000936 RHS Repeat; Region: RHS_repeat; pfam05593 1064551000937 RHS Repeat; Region: RHS_repeat; pfam05593 1064551000938 RHS protein; Region: RHS; pfam03527 1064551000939 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1064551000940 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1064551000941 RHS Repeat; Region: RHS_repeat; cl11982 1064551000942 RHS protein; Region: RHS; pfam03527 1064551000943 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1064551000944 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1064551000945 RHS protein; Region: RHS; pfam03527 1064551000946 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1064551000947 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 1064551000948 RHS Repeat; Region: RHS_repeat; cl11982 1064551000949 RHS Repeat; Region: RHS_repeat; pfam05593 1064551000950 RHS Repeat; Region: RHS_repeat; cl11982 1064551000951 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1064551000952 RHS Repeat; Region: RHS_repeat; pfam05593 1064551000953 RHS Repeat; Region: RHS_repeat; pfam05593 1064551000954 RHS Repeat; Region: RHS_repeat; pfam05593 1064551000955 RHS Repeat; Region: RHS_repeat; pfam05593 1064551000956 RHS protein; Region: RHS; pfam03527 1064551000957 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1064551000958 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1064551000959 RHS protein; Region: RHS; pfam03527 1064551000960 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1064551000961 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 1064551000962 Transposase; Region: HTH_Tnp_1; pfam01527 1064551000963 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1064551000964 Integrase core domain; Region: rve_3; pfam13683 1064551000965 Saf-pilin pilus formation protein SafA; Provisional; Region: PRK15221 1064551000966 Saf-pilin pilus formation protein; Region: Saf-Nte_pilin; cl09697 1064551000967 pili assembly chaperone protein SafB; Provisional; Region: PRK15224 1064551000968 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1064551000969 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1064551000970 pilin outer membrane usher protein SafC; Provisional; Region: PRK15223 1064551000971 PapC N-terminal domain; Region: PapC_N; pfam13954 1064551000972 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1064551000973 PapC C-terminal domain; Region: PapC_C; pfam13953 1064551000974 putative pilin structural protein SafD; Provisional; Region: PRK15222 1064551000975 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1064551000976 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 1064551000977 putative active site [active] 1064551000978 putative metal binding site [ion binding]; other site 1064551000979 PerC transcriptional activator; Region: PerC; pfam06069 1064551000980 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064551000981 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551000982 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1064551000983 dimerization interface [polypeptide binding]; other site 1064551000984 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1064551000985 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1064551000986 dimer interface [polypeptide binding]; other site 1064551000987 C-N hydrolase family amidase; Provisional; Region: PRK10438 1064551000988 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 1064551000989 putative active site [active] 1064551000990 catalytic triad [active] 1064551000991 dimer interface [polypeptide binding]; other site 1064551000992 multimer interface [polypeptide binding]; other site 1064551000993 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1064551000994 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1064551000995 active site 1064551000996 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1064551000997 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1064551000998 dimer interface [polypeptide binding]; other site 1064551000999 active site 1064551001000 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1064551001001 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1064551001002 putative active site [active] 1064551001003 putative dimer interface [polypeptide binding]; other site 1064551001004 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1064551001005 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1064551001006 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1064551001007 active site 1064551001008 DNA polymerase IV; Validated; Region: PRK02406 1064551001009 DNA binding site [nucleotide binding] 1064551001010 hypothetical protein; Reviewed; Region: PRK09588 1064551001011 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 1064551001012 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 1064551001013 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1064551001014 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 1064551001015 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 1064551001016 metal binding site [ion binding]; metal-binding site 1064551001017 dimer interface [polypeptide binding]; other site 1064551001018 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1064551001019 active site 1064551001020 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 1064551001021 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 1064551001022 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1064551001023 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1064551001024 trimer interface [polypeptide binding]; other site 1064551001025 eyelet of channel; other site 1064551001026 gamma-glutamyl kinase; Provisional; Region: PRK05429 1064551001027 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1064551001028 nucleotide binding site [chemical binding]; other site 1064551001029 homotetrameric interface [polypeptide binding]; other site 1064551001030 putative phosphate binding site [ion binding]; other site 1064551001031 putative allosteric binding site; other site 1064551001032 PUA domain; Region: PUA; pfam01472 1064551001033 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1064551001034 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1064551001035 putative catalytic cysteine [active] 1064551001036 putative transposase OrfB; Reviewed; Region: PHA02517 1064551001037 HTH-like domain; Region: HTH_21; pfam13276 1064551001038 Integrase core domain; Region: rve; pfam00665 1064551001039 Integrase core domain; Region: rve_2; pfam13333 1064551001040 Transposase; Region: HTH_Tnp_1; cl17663 1064551001041 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1064551001042 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1064551001043 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 1064551001044 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 1064551001045 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1064551001046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551001047 putative substrate translocation pore; other site 1064551001048 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1064551001049 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1064551001050 substrate binding site [chemical binding]; other site 1064551001051 ligand binding site [chemical binding]; other site 1064551001052 3-isopropylmalate dehydratase small subunit [Amino acid transport and metabolism]; Region: LeuD; COG0066 1064551001053 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1064551001054 hypothetical protein; Provisional; Region: PRK14812 1064551001055 substrate binding site [chemical binding]; other site 1064551001056 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1064551001057 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1064551001058 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1064551001059 transcriptional activator TtdR; Provisional; Region: PRK09801 1064551001060 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551001061 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 1064551001062 putative effector binding pocket; other site 1064551001063 putative dimerization interface [polypeptide binding]; other site 1064551001064 fimbrial assembly chaperone StbE; Provisional; Region: PRK15246 1064551001065 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1064551001066 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1064551001067 putative fimbrial usher protein StbD; Provisional; Region: PRK15247 1064551001068 fimbrial outer membrane usher protein StbC; Provisional; Region: PRK15248 1064551001069 PapC N-terminal domain; Region: PapC_N; pfam13954 1064551001070 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1064551001071 PapC C-terminal domain; Region: PapC_C; pfam13953 1064551001072 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1064551001073 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1064551001074 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1064551001075 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1064551001076 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1064551001077 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1064551001078 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1064551001079 DNA binding site [nucleotide binding] 1064551001080 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1064551001081 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 1064551001082 DNA binding residues [nucleotide binding] 1064551001083 dimerization interface [polypeptide binding]; other site 1064551001084 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 1064551001085 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1064551001086 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1064551001087 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1064551001088 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1064551001089 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064551001090 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1064551001091 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1064551001092 metal-binding site [ion binding] 1064551001093 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1064551001094 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064551001095 motif II; other site 1064551001096 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1064551001097 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1064551001098 DNA binding residues [nucleotide binding] 1064551001099 dimer interface [polypeptide binding]; other site 1064551001100 copper binding site [ion binding]; other site 1064551001101 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1064551001102 metal-binding site [ion binding] 1064551001103 putative sialic acid transporter; Region: 2A0112; TIGR00891 1064551001104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551001105 putative substrate translocation pore; other site 1064551001106 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1064551001107 DNA methylase; Region: N6_N4_Mtase; cl17433 1064551001108 DNA methylase; Region: N6_N4_Mtase; pfam01555 1064551001109 type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483 1064551001110 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1064551001111 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1064551001112 VRR-NUC domain; Region: VRR_NUC; pfam08774 1064551001113 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1064551001114 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1064551001115 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1064551001116 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1064551001117 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1064551001118 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1064551001119 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1064551001120 N-terminal plug; other site 1064551001121 ligand-binding site [chemical binding]; other site 1064551001122 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 1064551001123 hypothetical protein; Provisional; Region: PRK09929 1064551001124 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 1064551001125 Propionate catabolism activator; Region: PrpR_N; pfam06506 1064551001126 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064551001127 Walker A motif; other site 1064551001128 ATP binding site [chemical binding]; other site 1064551001129 Walker B motif; other site 1064551001130 arginine finger; other site 1064551001131 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1064551001132 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1064551001133 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1064551001134 tetramer interface [polypeptide binding]; other site 1064551001135 active site 1064551001136 Mg2+/Mn2+ binding site [ion binding]; other site 1064551001137 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1064551001138 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 1064551001139 dimer interface [polypeptide binding]; other site 1064551001140 active site 1064551001141 citrylCoA binding site [chemical binding]; other site 1064551001142 oxalacetate/citrate binding site [chemical binding]; other site 1064551001143 coenzyme A binding site [chemical binding]; other site 1064551001144 catalytic triad [active] 1064551001145 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 1064551001146 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1064551001147 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 1064551001148 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1064551001149 acyl-activating enzyme (AAE) consensus motif; other site 1064551001150 AMP binding site [chemical binding]; other site 1064551001151 active site 1064551001152 CoA binding site [chemical binding]; other site 1064551001153 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1064551001154 dimer interface [polypeptide binding]; other site 1064551001155 active site 1064551001156 Schiff base residues; other site 1064551001157 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 1064551001158 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1064551001159 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1064551001160 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 1064551001161 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1064551001162 ligand binding site [chemical binding]; other site 1064551001163 flexible hinge region; other site 1064551001164 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 1064551001165 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1064551001166 microcin B17 transporter; Reviewed; Region: PRK11098 1064551001167 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 1064551001168 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 1064551001169 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 1064551001170 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1064551001171 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1064551001172 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1064551001173 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 1064551001174 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 1064551001175 drug efflux system protein MdtG; Provisional; Region: PRK09874 1064551001176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551001177 putative substrate translocation pore; other site 1064551001178 anti-RssB factor; Provisional; Region: PRK10244 1064551001179 hypothetical protein; Provisional; Region: PRK11505 1064551001180 psiF repeat; Region: PsiF_repeat; pfam07769 1064551001181 psiF repeat; Region: PsiF_repeat; pfam07769 1064551001182 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 1064551001183 MASE2 domain; Region: MASE2; pfam05230 1064551001184 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064551001185 metal binding site [ion binding]; metal-binding site 1064551001186 active site 1064551001187 I-site; other site 1064551001188 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1064551001189 pyrroline-5-carboxylate reductase; Region: PLN02688 1064551001190 hypothetical protein; Validated; Region: PRK00124 1064551001191 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1064551001192 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1064551001193 ADP binding site [chemical binding]; other site 1064551001194 magnesium binding site [ion binding]; other site 1064551001195 putative shikimate binding site; other site 1064551001196 hypothetical protein; Provisional; Region: PRK10380 1064551001197 hypothetical protein; Provisional; Region: PRK10481 1064551001198 hypothetical protein; Provisional; Region: PRK10579 1064551001199 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 1064551001200 fructokinase; Reviewed; Region: PRK09557 1064551001201 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1064551001202 nucleotide binding site [chemical binding]; other site 1064551001203 MFS transport protein AraJ; Provisional; Region: PRK10091 1064551001204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551001205 putative substrate translocation pore; other site 1064551001206 exonuclease subunit SbcC; Provisional; Region: PRK10246 1064551001207 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064551001208 Walker A/P-loop; other site 1064551001209 ATP binding site [chemical binding]; other site 1064551001210 Q-loop/lid; other site 1064551001211 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064551001212 ABC transporter signature motif; other site 1064551001213 Walker B; other site 1064551001214 D-loop; other site 1064551001215 H-loop/switch region; other site 1064551001216 exonuclease subunit SbcD; Provisional; Region: PRK10966 1064551001217 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1064551001218 active site 1064551001219 metal binding site [ion binding]; metal-binding site 1064551001220 DNA binding site [nucleotide binding] 1064551001221 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1064551001222 transcriptional regulator PhoB; Provisional; Region: PRK10161 1064551001223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064551001224 active site 1064551001225 phosphorylation site [posttranslational modification] 1064551001226 intermolecular recognition site; other site 1064551001227 dimerization interface [polypeptide binding]; other site 1064551001228 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1064551001229 DNA binding site [nucleotide binding] 1064551001230 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 1064551001231 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 1064551001232 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064551001233 putative active site [active] 1064551001234 heme pocket [chemical binding]; other site 1064551001235 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064551001236 dimer interface [polypeptide binding]; other site 1064551001237 phosphorylation site [posttranslational modification] 1064551001238 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064551001239 ATP binding site [chemical binding]; other site 1064551001240 Mg2+ binding site [ion binding]; other site 1064551001241 G-X-G motif; other site 1064551001242 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 1064551001243 putative proline-specific permease; Provisional; Region: proY; PRK10580 1064551001244 maltodextrin glucosidase; Provisional; Region: PRK10785 1064551001245 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1064551001246 homodimer interface [polypeptide binding]; other site 1064551001247 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1064551001248 active site 1064551001249 homodimer interface [polypeptide binding]; other site 1064551001250 catalytic site [active] 1064551001251 peroxidase; Provisional; Region: PRK15000 1064551001252 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1064551001253 dimer interface [polypeptide binding]; other site 1064551001254 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1064551001255 catalytic triad [active] 1064551001256 peroxidatic and resolving cysteines [active] 1064551001257 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 1064551001258 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1064551001259 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1064551001260 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1064551001261 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 1064551001262 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1064551001263 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1064551001264 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1064551001265 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1064551001266 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1064551001267 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1064551001268 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1064551001269 Protein export membrane protein; Region: SecD_SecF; pfam02355 1064551001270 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1064551001271 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1064551001272 Predicted transcriptional regulator [Transcription]; Region: COG2378 1064551001273 HTH domain; Region: HTH_11; pfam08279 1064551001274 WYL domain; Region: WYL; pfam13280 1064551001275 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1064551001276 active site 1064551001277 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 1064551001278 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 1064551001279 hypothetical protein; Provisional; Region: PRK11530 1064551001280 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1064551001281 ATP cone domain; Region: ATP-cone; pfam03477 1064551001282 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1064551001283 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1064551001284 catalytic motif [active] 1064551001285 Zn binding site [ion binding]; other site 1064551001286 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 1064551001287 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1064551001288 homopentamer interface [polypeptide binding]; other site 1064551001289 active site 1064551001290 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1064551001291 putative RNA binding site [nucleotide binding]; other site 1064551001292 thiamine monophosphate kinase; Provisional; Region: PRK05731 1064551001293 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1064551001294 ATP binding site [chemical binding]; other site 1064551001295 dimerization interface [polypeptide binding]; other site 1064551001296 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1064551001297 tetramer interfaces [polypeptide binding]; other site 1064551001298 binuclear metal-binding site [ion binding]; other site 1064551001299 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1064551001300 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1064551001301 active site 1064551001302 catalytic tetrad [active] 1064551001303 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 1064551001304 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1064551001305 TPP-binding site; other site 1064551001306 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1064551001307 PYR/PP interface [polypeptide binding]; other site 1064551001308 dimer interface [polypeptide binding]; other site 1064551001309 TPP binding site [chemical binding]; other site 1064551001310 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1064551001311 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1064551001312 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1064551001313 substrate binding pocket [chemical binding]; other site 1064551001314 chain length determination region; other site 1064551001315 substrate-Mg2+ binding site; other site 1064551001316 catalytic residues [active] 1064551001317 aspartate-rich region 1; other site 1064551001318 active site lid residues [active] 1064551001319 aspartate-rich region 2; other site 1064551001320 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1064551001321 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 1064551001322 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1064551001323 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1064551001324 Ligand Binding Site [chemical binding]; other site 1064551001325 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1064551001326 active site residue [active] 1064551001327 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1064551001328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551001329 dimer interface [polypeptide binding]; other site 1064551001330 conserved gate region; other site 1064551001331 putative PBP binding loops; other site 1064551001332 ABC-ATPase subunit interface; other site 1064551001333 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 1064551001334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551001335 dimer interface [polypeptide binding]; other site 1064551001336 conserved gate region; other site 1064551001337 putative PBP binding loops; other site 1064551001338 ABC-ATPase subunit interface; other site 1064551001339 2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258 1064551001340 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064551001341 Walker A/P-loop; other site 1064551001342 ATP binding site [chemical binding]; other site 1064551001343 Q-loop/lid; other site 1064551001344 ABC transporter signature motif; other site 1064551001345 Walker B; other site 1064551001346 D-loop; other site 1064551001347 H-loop/switch region; other site 1064551001348 TOBE domain; Region: TOBE_2; pfam08402 1064551001349 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 1064551001350 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1064551001351 transcriptional regulator protein; Region: phnR; TIGR03337 1064551001352 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064551001353 DNA-binding site [nucleotide binding]; DNA binding site 1064551001354 UTRA domain; Region: UTRA; pfam07702 1064551001355 2-aminoethylphosphonate--pyruvate transaminase; Region: transamin_PhnW; TIGR02326 1064551001356 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1064551001357 catalytic residue [active] 1064551001358 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 1064551001359 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064551001360 motif II; other site 1064551001361 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 1064551001362 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1064551001363 conserved cys residue [active] 1064551001364 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1064551001365 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1064551001366 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1064551001367 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1064551001368 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1064551001369 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551001370 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1064551001371 putative substrate translocation pore; other site 1064551001372 Sel1-like repeats; Region: SEL1; smart00671 1064551001373 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1064551001374 Sel1 repeat; Region: Sel1; pfam08238 1064551001375 Sel1-like repeats; Region: SEL1; smart00671 1064551001376 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1064551001377 Sel1-like repeats; Region: SEL1; smart00671 1064551001378 Sel1-like repeats; Region: SEL1; smart00671 1064551001379 Sel1-like repeats; Region: SEL1; smart00671 1064551001380 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 1064551001381 UbiA prenyltransferase family; Region: UbiA; pfam01040 1064551001382 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 1064551001383 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1064551001384 Subunit I/III interface [polypeptide binding]; other site 1064551001385 Subunit III/IV interface [polypeptide binding]; other site 1064551001386 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1064551001387 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1064551001388 D-pathway; other site 1064551001389 Putative ubiquinol binding site [chemical binding]; other site 1064551001390 Low-spin heme (heme b) binding site [chemical binding]; other site 1064551001391 Putative water exit pathway; other site 1064551001392 Binuclear center (heme o3/CuB) [ion binding]; other site 1064551001393 K-pathway; other site 1064551001394 Putative proton exit pathway; other site 1064551001395 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 1064551001396 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1064551001397 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1064551001398 muropeptide transporter; Reviewed; Region: ampG; PRK11902 1064551001399 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551001400 putative substrate translocation pore; other site 1064551001401 hypothetical protein; Provisional; Region: PRK11627 1064551001402 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 1064551001403 transcriptional regulator BolA; Provisional; Region: PRK11628 1064551001404 trigger factor; Provisional; Region: tig; PRK01490 1064551001405 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1064551001406 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1064551001407 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1064551001408 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1064551001409 oligomer interface [polypeptide binding]; other site 1064551001410 active site residues [active] 1064551001411 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1064551001412 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1064551001413 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064551001414 Walker A motif; other site 1064551001415 ATP binding site [chemical binding]; other site 1064551001416 Walker B motif; other site 1064551001417 Iron permease FTR1 family; Region: FTR1; cl00475 1064551001418 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1064551001419 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 1064551001420 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1064551001421 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1064551001422 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064551001423 Walker A motif; other site 1064551001424 ATP binding site [chemical binding]; other site 1064551001425 Walker B motif; other site 1064551001426 arginine finger; other site 1064551001427 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1064551001428 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1064551001429 IHF dimer interface [polypeptide binding]; other site 1064551001430 IHF - DNA interface [nucleotide binding]; other site 1064551001431 periplasmic folding chaperone; Provisional; Region: PRK10788 1064551001432 SurA N-terminal domain; Region: SurA_N_3; cl07813 1064551001433 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1064551001434 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 1064551001435 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1064551001436 active site 1064551001437 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1064551001438 Ligand Binding Site [chemical binding]; other site 1064551001439 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1064551001440 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1064551001441 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1064551001442 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 1064551001443 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064551001444 active site 1064551001445 motif I; other site 1064551001446 motif II; other site 1064551001447 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1064551001448 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1064551001449 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1064551001450 catalytic residue [active] 1064551001451 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1064551001452 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1064551001453 putative DNA binding site [nucleotide binding]; other site 1064551001454 putative Zn2+ binding site [ion binding]; other site 1064551001455 AsnC family; Region: AsnC_trans_reg; pfam01037 1064551001456 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1064551001457 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1064551001458 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064551001459 Walker A/P-loop; other site 1064551001460 ATP binding site [chemical binding]; other site 1064551001461 Q-loop/lid; other site 1064551001462 ABC transporter signature motif; other site 1064551001463 Walker B; other site 1064551001464 D-loop; other site 1064551001465 H-loop/switch region; other site 1064551001466 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 1064551001467 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1064551001468 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064551001469 Walker A/P-loop; other site 1064551001470 ATP binding site [chemical binding]; other site 1064551001471 Q-loop/lid; other site 1064551001472 ABC transporter signature motif; other site 1064551001473 Walker B; other site 1064551001474 D-loop; other site 1064551001475 H-loop/switch region; other site 1064551001476 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 1064551001477 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1064551001478 ammonium transporter; Provisional; Region: PRK10666 1064551001479 acyl-CoA thioesterase II; Provisional; Region: PRK10526 1064551001480 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1064551001481 active site 1064551001482 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1064551001483 catalytic triad [active] 1064551001484 dimer interface [polypeptide binding]; other site 1064551001485 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 1064551001486 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1064551001487 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1064551001488 DNA binding site [nucleotide binding] 1064551001489 active site 1064551001490 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1064551001491 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1064551001492 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1064551001493 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1064551001494 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1064551001495 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 1064551001496 maltose O-acetyltransferase; Provisional; Region: PRK10092 1064551001497 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1064551001498 active site 1064551001499 substrate binding site [chemical binding]; other site 1064551001500 trimer interface [polypeptide binding]; other site 1064551001501 CoA binding site [chemical binding]; other site 1064551001502 gene expression modulator; Provisional; Region: PRK10945 1064551001503 Hha toxicity attenuator; Provisional; Region: PRK10667 1064551001504 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 1064551001505 Protein export membrane protein; Region: SecD_SecF; cl14618 1064551001506 Protein export membrane protein; Region: SecD_SecF; cl14618 1064551001507 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1064551001508 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064551001509 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 1064551001510 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1064551001511 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1064551001512 hypothetical protein; Provisional; Region: PRK11281 1064551001513 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1064551001514 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 1064551001515 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1064551001516 hypothetical protein; Provisional; Region: PRK11038 1064551001517 primosomal replication protein N''; Provisional; Region: PRK10093 1064551001518 hypothetical protein; Provisional; Region: PRK10527 1064551001519 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1064551001520 active site 1064551001521 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 1064551001522 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064551001523 Walker A motif; other site 1064551001524 ATP binding site [chemical binding]; other site 1064551001525 Walker B motif; other site 1064551001526 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1064551001527 arginine finger; other site 1064551001528 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1064551001529 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 1064551001530 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 1064551001531 hypothetical protein; Validated; Region: PRK00153 1064551001532 recombination protein RecR; Reviewed; Region: recR; PRK00076 1064551001533 RecR protein; Region: RecR; pfam02132 1064551001534 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1064551001535 putative active site [active] 1064551001536 putative metal-binding site [ion binding]; other site 1064551001537 tetramer interface [polypeptide binding]; other site 1064551001538 heat shock protein 90; Provisional; Region: PRK05218 1064551001539 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064551001540 ATP binding site [chemical binding]; other site 1064551001541 Mg2+ binding site [ion binding]; other site 1064551001542 G-X-G motif; other site 1064551001543 adenylate kinase; Reviewed; Region: adk; PRK00279 1064551001544 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1064551001545 AMP-binding site [chemical binding]; other site 1064551001546 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1064551001547 ferrochelatase; Reviewed; Region: hemH; PRK00035 1064551001548 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1064551001549 C-terminal domain interface [polypeptide binding]; other site 1064551001550 active site 1064551001551 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1064551001552 active site 1064551001553 N-terminal domain interface [polypeptide binding]; other site 1064551001554 acetyl esterase; Provisional; Region: PRK10162 1064551001555 inosine/guanosine kinase; Provisional; Region: PRK15074 1064551001556 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1064551001557 putative cation:proton antiport protein; Provisional; Region: PRK10669 1064551001558 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 1064551001559 TrkA-N domain; Region: TrkA_N; pfam02254 1064551001560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551001561 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1064551001562 putative substrate translocation pore; other site 1064551001563 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 1064551001564 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 1064551001565 active site 1064551001566 metal binding site [ion binding]; metal-binding site 1064551001567 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1064551001568 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1064551001569 putative deacylase active site [active] 1064551001570 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 1064551001571 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1064551001572 copper exporting ATPase; Provisional; Region: copA; PRK10671 1064551001573 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1064551001574 metal-binding site [ion binding] 1064551001575 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1064551001576 metal-binding site [ion binding] 1064551001577 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1064551001578 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064551001579 motif II; other site 1064551001580 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 1064551001581 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1064551001582 DNA binding residues [nucleotide binding] 1064551001583 dimer interface [polypeptide binding]; other site 1064551001584 copper binding site [ion binding]; other site 1064551001585 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1064551001586 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1064551001587 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1064551001588 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 1064551001589 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1064551001590 Walker A/P-loop; other site 1064551001591 ATP binding site [chemical binding]; other site 1064551001592 Q-loop/lid; other site 1064551001593 ABC transporter signature motif; other site 1064551001594 Walker B; other site 1064551001595 D-loop; other site 1064551001596 H-loop/switch region; other site 1064551001597 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1064551001598 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1064551001599 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1064551001600 oxidoreductase; Provisional; Region: PRK08017 1064551001601 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1064551001602 NADP binding site [chemical binding]; other site 1064551001603 active site 1064551001604 steroid binding site; other site 1064551001605 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1064551001606 active site 1064551001607 catalytic triad [active] 1064551001608 oxyanion hole [active] 1064551001609 switch loop; other site 1064551001610 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 1064551001611 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1064551001612 Walker A/P-loop; other site 1064551001613 ATP binding site [chemical binding]; other site 1064551001614 Q-loop/lid; other site 1064551001615 ABC transporter signature motif; other site 1064551001616 Walker B; other site 1064551001617 D-loop; other site 1064551001618 H-loop/switch region; other site 1064551001619 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1064551001620 FtsX-like permease family; Region: FtsX; pfam02687 1064551001621 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1064551001622 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1064551001623 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1064551001624 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1064551001625 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1064551001626 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1064551001627 Walker A/P-loop; other site 1064551001628 ATP binding site [chemical binding]; other site 1064551001629 Q-loop/lid; other site 1064551001630 ABC transporter signature motif; other site 1064551001631 Walker B; other site 1064551001632 D-loop; other site 1064551001633 H-loop/switch region; other site 1064551001634 NIL domain; Region: NIL; pfam09383 1064551001635 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551001636 dimer interface [polypeptide binding]; other site 1064551001637 conserved gate region; other site 1064551001638 ABC-ATPase subunit interface; other site 1064551001639 Predicted ATPase [General function prediction only]; Region: COG2603 1064551001640 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 1064551001641 active site residue [active] 1064551001642 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 1064551001643 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551001644 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1064551001645 dimerization interface [polypeptide binding]; other site 1064551001646 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 1064551001647 ureidoglycolate hydrolase; Provisional; Region: PRK03606 1064551001648 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 1064551001649 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1064551001650 Bacterial transcriptional regulator; Region: IclR; pfam01614 1064551001651 glyoxylate carboligase; Provisional; Region: PRK11269 1064551001652 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1064551001653 PYR/PP interface [polypeptide binding]; other site 1064551001654 dimer interface [polypeptide binding]; other site 1064551001655 TPP binding site [chemical binding]; other site 1064551001656 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1064551001657 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 1064551001658 TPP-binding site [chemical binding]; other site 1064551001659 hydroxypyruvate isomerase; Provisional; Region: PRK09997 1064551001660 tartronate semialdehyde reductase; Provisional; Region: PRK15059 1064551001661 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1064551001662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551001663 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1064551001664 putative substrate translocation pore; other site 1064551001665 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 1064551001666 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1064551001667 Na binding site [ion binding]; other site 1064551001668 putative substrate binding site [chemical binding]; other site 1064551001669 allantoinase; Provisional; Region: PRK08044 1064551001670 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 1064551001671 active site 1064551001672 putative uracil/xanthine transporter; Provisional; Region: PRK11412 1064551001673 glycerate kinase II; Provisional; Region: PRK09932 1064551001674 Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257 1064551001675 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 1064551001676 Cupin domain; Region: Cupin_2; pfam07883 1064551001677 allantoate amidohydrolase; Region: AllC; TIGR03176 1064551001678 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1064551001679 active site 1064551001680 metal binding site [ion binding]; metal-binding site 1064551001681 dimer interface [polypeptide binding]; other site 1064551001682 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 1064551001683 membrane protein FdrA; Validated; Region: PRK06091 1064551001684 CoA binding domain; Region: CoA_binding; pfam02629 1064551001685 CoA-ligase; Region: Ligase_CoA; pfam00549 1064551001686 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 1064551001687 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 1064551001688 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1064551001689 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1064551001690 putative substrate binding site [chemical binding]; other site 1064551001691 nucleotide binding site [chemical binding]; other site 1064551001692 nucleotide binding site [chemical binding]; other site 1064551001693 homodimer interface [polypeptide binding]; other site 1064551001694 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1064551001695 ATP-grasp domain; Region: ATP-grasp; pfam02222 1064551001696 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1064551001697 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1064551001698 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1064551001699 putative active site [active] 1064551001700 putative metal binding site [ion binding]; other site 1064551001701 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1064551001702 substrate binding site [chemical binding]; other site 1064551001703 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1064551001704 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1064551001705 active site 1064551001706 HIGH motif; other site 1064551001707 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1064551001708 KMSKS motif; other site 1064551001709 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1064551001710 tRNA binding surface [nucleotide binding]; other site 1064551001711 anticodon binding site; other site 1064551001712 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4727 1064551001713 Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916 1064551001714 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1064551001715 ribosome-associated protein; Provisional; Region: PRK11507 1064551001716 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 1064551001717 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1064551001718 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1064551001719 homodimer interface [polypeptide binding]; other site 1064551001720 NADP binding site [chemical binding]; other site 1064551001721 substrate binding site [chemical binding]; other site 1064551001722 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 1064551001723 fimbrial protein FimI; Provisional; Region: PRK15200 1064551001724 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 1064551001725 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1064551001726 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1064551001727 outer membrane usher protein FimD; Provisional; Region: PRK15198 1064551001728 PapC N-terminal domain; Region: PapC_N; pfam13954 1064551001729 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1064551001730 PapC C-terminal domain; Region: PapC_C; pfam13953 1064551001731 fimbrial-like adhesin; Provisional; Region: fimH; PRK15199 1064551001732 fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934 1064551001733 transcriptional regulator FimZ; Provisional; Region: PRK09935 1064551001734 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064551001735 active site 1064551001736 phosphorylation site [posttranslational modification] 1064551001737 intermolecular recognition site; other site 1064551001738 dimerization interface [polypeptide binding]; other site 1064551001739 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064551001740 DNA binding residues [nucleotide binding] 1064551001741 dimerization interface [polypeptide binding]; other site 1064551001742 fimbriae regulatory protein FimW; Provisional; Region: PRK15201 1064551001743 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064551001744 DNA binding residues [nucleotide binding] 1064551001745 dimerization interface [polypeptide binding]; other site 1064551001746 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1064551001747 Predicted membrane protein [Function unknown]; Region: COG2246 1064551001748 GtrA-like protein; Region: GtrA; pfam04138 1064551001749 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1064551001750 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1064551001751 Ligand binding site; other site 1064551001752 Putative Catalytic site; other site 1064551001753 DXD motif; other site 1064551001754 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1064551001755 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1064551001756 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1064551001757 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1064551001758 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1064551001759 Ligand binding site; other site 1064551001760 Putative Catalytic site; other site 1064551001761 DXD motif; other site 1064551001762 Predicted membrane protein [Function unknown]; Region: COG2246 1064551001763 GtrA-like protein; Region: GtrA; pfam04138 1064551001764 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064551001765 ATP binding site [chemical binding]; other site 1064551001766 Mg2+ binding site [ion binding]; other site 1064551001767 G-X-G motif; other site 1064551001768 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 1064551001769 Cupin; Region: Cupin_6; pfam12852 1064551001770 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1064551001771 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064551001772 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064551001773 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 1064551001774 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1064551001775 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1064551001776 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1064551001777 Predicted membrane protein [Function unknown]; Region: COG3059 1064551001778 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 1064551001779 phenylalanine transporter; Provisional; Region: PRK10249 1064551001780 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1064551001781 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1064551001782 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 1064551001783 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1064551001784 active site 1064551001785 oxyanion hole [active] 1064551001786 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1064551001787 catalytic triad [active] 1064551001788 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 1064551001789 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1064551001790 dimer interface [polypeptide binding]; other site 1064551001791 FMN binding site [chemical binding]; other site 1064551001792 hypothetical protein; Provisional; Region: PRK10250 1064551001793 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1064551001794 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1064551001795 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1064551001796 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064551001797 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 1064551001798 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 1064551001799 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1064551001800 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 1064551001801 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1064551001802 outer membrane receptor FepA; Provisional; Region: PRK13524 1064551001803 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1064551001804 N-terminal plug; other site 1064551001805 ligand-binding site [chemical binding]; other site 1064551001806 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 1064551001807 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1064551001808 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1064551001809 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1064551001810 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1064551001811 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1064551001812 acyl-activating enzyme (AAE) consensus motif; other site 1064551001813 AMP binding site [chemical binding]; other site 1064551001814 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1064551001815 LPS O-antigen length regulator; Provisional; Region: PRK10381 1064551001816 Chain length determinant protein; Region: Wzz; pfam02706 1064551001817 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 1064551001818 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1064551001819 Walker A/P-loop; other site 1064551001820 ATP binding site [chemical binding]; other site 1064551001821 Q-loop/lid; other site 1064551001822 ABC transporter signature motif; other site 1064551001823 Walker B; other site 1064551001824 D-loop; other site 1064551001825 H-loop/switch region; other site 1064551001826 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1064551001827 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1064551001828 ABC-ATPase subunit interface; other site 1064551001829 dimer interface [polypeptide binding]; other site 1064551001830 putative PBP binding regions; other site 1064551001831 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1064551001832 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1064551001833 ABC-ATPase subunit interface; other site 1064551001834 dimer interface [polypeptide binding]; other site 1064551001835 putative PBP binding regions; other site 1064551001836 enterobactin exporter EntS; Provisional; Region: PRK10489 1064551001837 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551001838 putative substrate translocation pore; other site 1064551001839 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 1064551001840 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1064551001841 siderophore binding site; other site 1064551001842 isochorismate synthase EntC; Provisional; Region: PRK15016 1064551001843 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1064551001844 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 1064551001845 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1064551001846 acyl-activating enzyme (AAE) consensus motif; other site 1064551001847 active site 1064551001848 AMP binding site [chemical binding]; other site 1064551001849 substrate binding site [chemical binding]; other site 1064551001850 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1064551001851 hydrophobic substrate binding pocket; other site 1064551001852 Isochorismatase family; Region: Isochorismatase; pfam00857 1064551001853 active site 1064551001854 conserved cis-peptide bond; other site 1064551001855 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1064551001856 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1064551001857 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 1064551001858 putative NAD(P) binding site [chemical binding]; other site 1064551001859 active site 1064551001860 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1064551001861 CoenzymeA binding site [chemical binding]; other site 1064551001862 subunit interaction site [polypeptide binding]; other site 1064551001863 PHB binding site; other site 1064551001864 carbon starvation protein A; Provisional; Region: PRK15015 1064551001865 Carbon starvation protein CstA; Region: CstA; pfam02554 1064551001866 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1064551001867 Uncharacterized small protein [Function unknown]; Region: COG2879 1064551001868 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1064551001869 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 1064551001870 putative active site [active] 1064551001871 metal binding site [ion binding]; metal-binding site 1064551001872 methionine aminotransferase; Validated; Region: PRK09082 1064551001873 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1064551001874 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551001875 homodimer interface [polypeptide binding]; other site 1064551001876 catalytic residue [active] 1064551001877 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1064551001878 ParB-like nuclease domain; Region: ParBc; pfam02195 1064551001879 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 1064551001880 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1064551001881 Active Sites [active] 1064551001882 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 1064551001883 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 1064551001884 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551001885 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1064551001886 dimerization interface [polypeptide binding]; other site 1064551001887 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 1064551001888 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1064551001889 dimerization domain [polypeptide binding]; other site 1064551001890 dimer interface [polypeptide binding]; other site 1064551001891 catalytic residues [active] 1064551001892 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 1064551001893 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1064551001894 dimer interface [polypeptide binding]; other site 1064551001895 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1064551001896 catalytic triad [active] 1064551001897 peroxidatic and resolving cysteines [active] 1064551001898 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1064551001899 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1064551001900 catalytic residue [active] 1064551001901 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1064551001902 catalytic residues [active] 1064551001903 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1064551001904 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1064551001905 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 1064551001906 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1064551001907 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1064551001908 putative [4Fe-4S] binding site [ion binding]; other site 1064551001909 putative molybdopterin cofactor binding site [chemical binding]; other site 1064551001910 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 1064551001911 molybdopterin cofactor binding site; other site 1064551001912 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 1064551001913 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1064551001914 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 1064551001915 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1064551001916 Ligand Binding Site [chemical binding]; other site 1064551001917 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1064551001918 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1064551001919 NAD binding site [chemical binding]; other site 1064551001920 catalytic Zn binding site [ion binding]; other site 1064551001921 structural Zn binding site [ion binding]; other site 1064551001922 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1064551001923 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1064551001924 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 1064551001925 B1 nucleotide binding pocket [chemical binding]; other site 1064551001926 B2 nucleotide binding pocket [chemical binding]; other site 1064551001927 CAS motifs; other site 1064551001928 active site 1064551001929 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1064551001930 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1064551001931 transmembrane helices; other site 1064551001932 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 1064551001933 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 1064551001934 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 1064551001935 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1064551001936 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1064551001937 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 1064551001938 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 1064551001939 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 1064551001940 putative active site [active] 1064551001941 (T/H)XGH motif; other site 1064551001942 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 1064551001943 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064551001944 putative active site [active] 1064551001945 heme pocket [chemical binding]; other site 1064551001946 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064551001947 ATP binding site [chemical binding]; other site 1064551001948 Mg2+ binding site [ion binding]; other site 1064551001949 G-X-G motif; other site 1064551001950 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 1064551001951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064551001952 active site 1064551001953 phosphorylation site [posttranslational modification] 1064551001954 intermolecular recognition site; other site 1064551001955 dimerization interface [polypeptide binding]; other site 1064551001956 Transcriptional regulator; Region: CitT; pfam12431 1064551001957 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 1064551001958 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1064551001959 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 1064551001960 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1064551001961 DNA-binding site [nucleotide binding]; DNA binding site 1064551001962 RNA-binding motif; other site 1064551001963 chromosome condensation membrane protein; Provisional; Region: PRK14196 1064551001964 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1064551001965 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1064551001966 putative active site [active] 1064551001967 catalytic triad [active] 1064551001968 putative dimer interface [polypeptide binding]; other site 1064551001969 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 1064551001970 lipoyl synthase; Provisional; Region: PRK05481 1064551001971 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064551001972 FeS/SAM binding site; other site 1064551001973 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 1064551001974 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551001975 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1064551001976 substrate binding pocket [chemical binding]; other site 1064551001977 dimerization interface [polypeptide binding]; other site 1064551001978 lipoate-protein ligase B; Provisional; Region: PRK14342 1064551001979 hypothetical protein; Provisional; Region: PRK04998 1064551001980 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 1064551001981 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1064551001982 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1064551001983 rare lipoprotein A; Provisional; Region: PRK10672 1064551001984 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1064551001985 Sporulation related domain; Region: SPOR; pfam05036 1064551001986 cell wall shape-determining protein; Provisional; Region: PRK10794 1064551001987 penicillin-binding protein 2; Provisional; Region: PRK10795 1064551001988 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1064551001989 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1064551001990 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 1064551001991 ribosome-associated protein; Provisional; Region: PRK11538 1064551001992 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1064551001993 catalytic core [active] 1064551001994 threonine-phosphate decarboxylase; Provisional; Region: PRK08056 1064551001995 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1064551001996 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551001997 homodimer interface [polypeptide binding]; other site 1064551001998 catalytic residue [active] 1064551001999 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1064551002000 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1064551002001 active site 1064551002002 (T/H)XGH motif; other site 1064551002003 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1064551002004 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1064551002005 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 1064551002006 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1064551002007 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1064551002008 HIGH motif; other site 1064551002009 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1064551002010 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1064551002011 active site 1064551002012 KMSKS motif; other site 1064551002013 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1064551002014 tRNA binding surface [nucleotide binding]; other site 1064551002015 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1064551002016 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1064551002017 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 1064551002018 Propionate catabolism activator; Region: PrpR_N; pfam06506 1064551002019 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1064551002020 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064551002021 Walker A motif; other site 1064551002022 ATP binding site [chemical binding]; other site 1064551002023 Walker B motif; other site 1064551002024 arginine finger; other site 1064551002025 hypothetical protein; Provisional; Region: PRK11032 1064551002026 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1064551002027 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1064551002028 Sel1-like repeats; Region: SEL1; smart00671 1064551002029 Sel1-like repeats; Region: SEL1; smart00671 1064551002030 Sel1-like repeats; Region: SEL1; smart00671 1064551002031 Sel1-like repeats; Region: SEL1; smart00671 1064551002032 Sel1-like repeats; Region: SEL1; smart00671 1064551002033 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 1064551002034 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 1064551002035 HSP70 interaction site [polypeptide binding]; other site 1064551002036 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 1064551002037 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 1064551002038 HSP70 interaction site [polypeptide binding]; other site 1064551002039 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1064551002040 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 1064551002041 nucleotide binding site [chemical binding]; other site 1064551002042 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1064551002043 SBD interface [polypeptide binding]; other site 1064551002044 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1064551002045 active site 1064551002046 tetramer interface [polypeptide binding]; other site 1064551002047 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1064551002048 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1064551002049 Walker A/P-loop; other site 1064551002050 ATP binding site [chemical binding]; other site 1064551002051 Q-loop/lid; other site 1064551002052 ABC transporter signature motif; other site 1064551002053 Walker B; other site 1064551002054 D-loop; other site 1064551002055 H-loop/switch region; other site 1064551002056 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1064551002057 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551002058 dimer interface [polypeptide binding]; other site 1064551002059 conserved gate region; other site 1064551002060 putative PBP binding loops; other site 1064551002061 ABC-ATPase subunit interface; other site 1064551002062 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1064551002063 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551002064 dimer interface [polypeptide binding]; other site 1064551002065 conserved gate region; other site 1064551002066 putative PBP binding loops; other site 1064551002067 ABC-ATPase subunit interface; other site 1064551002068 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 1064551002069 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064551002070 substrate binding pocket [chemical binding]; other site 1064551002071 membrane-bound complex binding site; other site 1064551002072 hinge residues; other site 1064551002073 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1064551002074 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1064551002075 putative active site [active] 1064551002076 catalytic triad [active] 1064551002077 putative dimer interface [polypeptide binding]; other site 1064551002078 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 1064551002079 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1064551002080 Transporter associated domain; Region: CorC_HlyC; smart01091 1064551002081 metal-binding heat shock protein; Provisional; Region: PRK00016 1064551002082 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1064551002083 PhoH-like protein; Region: PhoH; pfam02562 1064551002084 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1064551002085 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1064551002086 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064551002087 FeS/SAM binding site; other site 1064551002088 TRAM domain; Region: TRAM; pfam01938 1064551002089 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 1064551002090 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1064551002091 asparagine synthetase B; Provisional; Region: asnB; PRK09431 1064551002092 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1064551002093 active site 1064551002094 dimer interface [polypeptide binding]; other site 1064551002095 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1064551002096 Ligand Binding Site [chemical binding]; other site 1064551002097 Molecular Tunnel; other site 1064551002098 UMP phosphatase; Provisional; Region: PRK10444 1064551002099 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064551002100 active site 1064551002101 motif I; other site 1064551002102 motif II; other site 1064551002103 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064551002104 MarR family; Region: MarR; pfam01047 1064551002105 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1064551002106 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1064551002107 nucleotide binding site [chemical binding]; other site 1064551002108 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1064551002109 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1064551002110 active site 1064551002111 dimer interface [polypeptide binding]; other site 1064551002112 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1064551002113 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1064551002114 active site 1064551002115 trimer interface [polypeptide binding]; other site 1064551002116 allosteric site; other site 1064551002117 active site lid [active] 1064551002118 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1064551002119 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 1064551002120 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1064551002121 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1064551002122 active site turn [active] 1064551002123 phosphorylation site [posttranslational modification] 1064551002124 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1064551002125 HPr interaction site; other site 1064551002126 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1064551002127 active site 1064551002128 phosphorylation site [posttranslational modification] 1064551002129 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1064551002130 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1064551002131 active site 1064551002132 HIGH motif; other site 1064551002133 nucleotide binding site [chemical binding]; other site 1064551002134 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1064551002135 KMSKS motif; other site 1064551002136 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1064551002137 outer membrane porin, OprD family; Region: OprD; pfam03573 1064551002138 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1064551002139 YbfN-like lipoprotein; Region: YbfN; pfam13982 1064551002140 citrate-proton symporter; Provisional; Region: PRK15075 1064551002141 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551002142 putative substrate translocation pore; other site 1064551002143 tricarballylate utilization protein B; Provisional; Region: PRK15033 1064551002144 tricarballylate dehydrogenase; Validated; Region: PRK08274 1064551002145 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1064551002146 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064551002147 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551002148 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1064551002149 putative dimerization interface [polypeptide binding]; other site 1064551002150 ferric uptake regulator; Provisional; Region: fur; PRK09462 1064551002151 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1064551002152 metal binding site 2 [ion binding]; metal-binding site 1064551002153 putative DNA binding helix; other site 1064551002154 metal binding site 1 [ion binding]; metal-binding site 1064551002155 dimer interface [polypeptide binding]; other site 1064551002156 structural Zn2+ binding site [ion binding]; other site 1064551002157 flavodoxin FldA; Validated; Region: PRK09267 1064551002158 LexA regulated protein; Provisional; Region: PRK11675 1064551002159 acyl-CoA esterase; Provisional; Region: PRK10673 1064551002160 PGAP1-like protein; Region: PGAP1; pfam07819 1064551002161 replication initiation regulator SeqA; Provisional; Region: PRK11187 1064551002162 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 1064551002163 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1064551002164 active site 1064551002165 substrate binding site [chemical binding]; other site 1064551002166 metal binding site [ion binding]; metal-binding site 1064551002167 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 1064551002168 putrescine transporter; Provisional; Region: potE; PRK10655 1064551002169 ornithine decarboxylase; Provisional; Region: PRK13578 1064551002170 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1064551002171 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1064551002172 homodimer interface [polypeptide binding]; other site 1064551002173 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551002174 catalytic residue [active] 1064551002175 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1064551002176 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1064551002177 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064551002178 active site 1064551002179 phosphorylation site [posttranslational modification] 1064551002180 intermolecular recognition site; other site 1064551002181 dimerization interface [polypeptide binding]; other site 1064551002182 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1064551002183 DNA binding site [nucleotide binding] 1064551002184 sensor protein KdpD; Provisional; Region: PRK10490 1064551002185 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1064551002186 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1064551002187 Ligand Binding Site [chemical binding]; other site 1064551002188 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1064551002189 GAF domain; Region: GAF_3; pfam13492 1064551002190 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064551002191 dimer interface [polypeptide binding]; other site 1064551002192 phosphorylation site [posttranslational modification] 1064551002193 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064551002194 ATP binding site [chemical binding]; other site 1064551002195 Mg2+ binding site [ion binding]; other site 1064551002196 G-X-G motif; other site 1064551002197 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1064551002198 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1064551002199 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1064551002200 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1064551002201 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 1064551002202 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 1064551002203 DNA photolyase; Region: DNA_photolyase; pfam00875 1064551002204 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1064551002205 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551002206 putative substrate translocation pore; other site 1064551002207 POT family; Region: PTR2; pfam00854 1064551002208 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1064551002209 metal-binding protein; Provisional; Region: PRK10799 1064551002210 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1064551002211 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1064551002212 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1064551002213 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 1064551002214 putative active site [active] 1064551002215 endonuclease VIII; Provisional; Region: PRK10445 1064551002216 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 1064551002217 DNA binding site [nucleotide binding] 1064551002218 catalytic residue [active] 1064551002219 putative catalytic residues [active] 1064551002220 H2TH interface [polypeptide binding]; other site 1064551002221 intercalation triad [nucleotide binding]; other site 1064551002222 substrate specificity determining residue; other site 1064551002223 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1064551002224 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1064551002225 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 1064551002226 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1064551002227 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1064551002228 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1064551002229 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1064551002230 dimer interface [polypeptide binding]; other site 1064551002231 active site 1064551002232 citrylCoA binding site [chemical binding]; other site 1064551002233 NADH binding [chemical binding]; other site 1064551002234 cationic pore residues; other site 1064551002235 oxalacetate/citrate binding site [chemical binding]; other site 1064551002236 coenzyme A binding site [chemical binding]; other site 1064551002237 catalytic triad [active] 1064551002238 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1064551002239 Iron-sulfur protein interface; other site 1064551002240 proximal quinone binding site [chemical binding]; other site 1064551002241 SdhD (CybS) interface [polypeptide binding]; other site 1064551002242 proximal heme binding site [chemical binding]; other site 1064551002243 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1064551002244 SdhC subunit interface [polypeptide binding]; other site 1064551002245 proximal heme binding site [chemical binding]; other site 1064551002246 cardiolipin binding site; other site 1064551002247 Iron-sulfur protein interface; other site 1064551002248 proximal quinone binding site [chemical binding]; other site 1064551002249 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 1064551002250 L-aspartate oxidase; Provisional; Region: PRK06175 1064551002251 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1064551002252 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1064551002253 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1064551002254 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1064551002255 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1064551002256 TPP-binding site [chemical binding]; other site 1064551002257 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1064551002258 dimer interface [polypeptide binding]; other site 1064551002259 PYR/PP interface [polypeptide binding]; other site 1064551002260 TPP binding site [chemical binding]; other site 1064551002261 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1064551002262 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1064551002263 E3 interaction surface; other site 1064551002264 lipoyl attachment site [posttranslational modification]; other site 1064551002265 e3 binding domain; Region: E3_binding; pfam02817 1064551002266 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1064551002267 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1064551002268 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1064551002269 CoA-ligase; Region: Ligase_CoA; pfam00549 1064551002270 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1064551002271 CoA binding domain; Region: CoA_binding; smart00881 1064551002272 CoA-ligase; Region: Ligase_CoA; pfam00549 1064551002273 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1064551002274 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1064551002275 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 1064551002276 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1064551002277 Predicted outer membrane lipoprotein [Function unknown]; Region: COG4890 1064551002278 hypothetical protein; Provisional; Region: PRK10588 1064551002279 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1064551002280 active site 1064551002281 colicin uptake protein TolQ; Provisional; Region: PRK10801 1064551002282 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1064551002283 colicin uptake protein TolR; Provisional; Region: PRK11024 1064551002284 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 1064551002285 TolA C-terminal; Region: TolA; pfam06519 1064551002286 translocation protein TolB; Provisional; Region: tolB; PRK03629 1064551002287 TolB amino-terminal domain; Region: TolB_N; pfam04052 1064551002288 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1064551002289 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1064551002290 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1064551002291 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 1064551002292 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1064551002293 ligand binding site [chemical binding]; other site 1064551002294 tol-pal system protein YbgF; Provisional; Region: PRK10803 1064551002295 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1064551002296 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1064551002297 quinolinate synthetase; Provisional; Region: PRK09375 1064551002298 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 1064551002299 zinc transporter ZitB; Provisional; Region: PRK03557 1064551002300 YbgS-like protein; Region: YbgS; pfam13985 1064551002301 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1064551002302 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1064551002303 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Region: FumA; COG1838 1064551002304 fumarate hydratase; Provisional; Region: PRK06246 1064551002305 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064551002306 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551002307 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1064551002308 dimerization interface [polypeptide binding]; other site 1064551002309 cell density-dependent motility repressor; Provisional; Region: PRK10082 1064551002310 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551002311 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1064551002312 dimerization interface [polypeptide binding]; other site 1064551002313 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1064551002314 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1064551002315 transmembrane helices; other site 1064551002316 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 1064551002317 oxaloacetate decarboxylase; Provisional; Region: PRK14040 1064551002318 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1064551002319 active site 1064551002320 catalytic residues [active] 1064551002321 metal binding site [ion binding]; metal-binding site 1064551002322 homodimer binding site [polypeptide binding]; other site 1064551002323 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1064551002324 carboxyltransferase (CT) interaction site; other site 1064551002325 biotinylation site [posttranslational modification]; other site 1064551002326 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 1064551002327 Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767 1064551002328 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1064551002329 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1064551002330 dimer interface [polypeptide binding]; other site 1064551002331 putative PBP binding regions; other site 1064551002332 ABC-ATPase subunit interface; other site 1064551002333 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1064551002334 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1064551002335 Walker A/P-loop; other site 1064551002336 ATP binding site [chemical binding]; other site 1064551002337 Q-loop/lid; other site 1064551002338 ABC transporter signature motif; other site 1064551002339 Walker B; other site 1064551002340 D-loop; other site 1064551002341 H-loop/switch region; other site 1064551002342 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1064551002343 catalytic core [active] 1064551002344 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1064551002345 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1064551002346 active site 1064551002347 catalytic residues [active] 1064551002348 galactokinase; Provisional; Region: PRK05101 1064551002349 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1064551002350 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1064551002351 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 1064551002352 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1064551002353 dimer interface [polypeptide binding]; other site 1064551002354 active site 1064551002355 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 1064551002356 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1064551002357 NAD binding site [chemical binding]; other site 1064551002358 homodimer interface [polypeptide binding]; other site 1064551002359 active site 1064551002360 substrate binding site [chemical binding]; other site 1064551002361 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4714 1064551002362 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 1064551002363 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064551002364 Walker A/P-loop; other site 1064551002365 ATP binding site [chemical binding]; other site 1064551002366 Q-loop/lid; other site 1064551002367 ABC transporter signature motif; other site 1064551002368 Walker B; other site 1064551002369 D-loop; other site 1064551002370 H-loop/switch region; other site 1064551002371 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064551002372 Walker A/P-loop; other site 1064551002373 ATP binding site [chemical binding]; other site 1064551002374 Q-loop/lid; other site 1064551002375 ABC transporter signature motif; other site 1064551002376 Walker B; other site 1064551002377 D-loop; other site 1064551002378 H-loop/switch region; other site 1064551002379 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 1064551002380 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1064551002381 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1064551002382 TOBE domain; Region: TOBE; pfam03459 1064551002383 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 1064551002384 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 1064551002385 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064551002386 substrate binding pocket [chemical binding]; other site 1064551002387 membrane-bound complex binding site; other site 1064551002388 hinge residues; other site 1064551002389 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1064551002390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551002391 dimer interface [polypeptide binding]; other site 1064551002392 conserved gate region; other site 1064551002393 putative PBP binding loops; other site 1064551002394 ABC-ATPase subunit interface; other site 1064551002395 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 1064551002396 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064551002397 Walker A/P-loop; other site 1064551002398 ATP binding site [chemical binding]; other site 1064551002399 Q-loop/lid; other site 1064551002400 ABC transporter signature motif; other site 1064551002401 Walker B; other site 1064551002402 D-loop; other site 1064551002403 H-loop/switch region; other site 1064551002404 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1064551002405 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 1064551002406 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064551002407 active site 1064551002408 motif I; other site 1064551002409 motif II; other site 1064551002410 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064551002411 6-phosphogluconolactonase; Provisional; Region: PRK11028 1064551002412 acyl-CoA thioesterase; Provisional; Region: PRK10531 1064551002413 putative pectinesterase; Region: PLN02432; cl01911 1064551002414 imidazolonepropionase; Validated; Region: PRK09356 1064551002415 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1064551002416 active site 1064551002417 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 1064551002418 putative active site [active] 1064551002419 putative metal binding site [ion binding]; other site 1064551002420 histidine utilization repressor; Provisional; Region: PRK14999 1064551002421 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064551002422 DNA-binding site [nucleotide binding]; DNA binding site 1064551002423 UTRA domain; Region: UTRA; pfam07702 1064551002424 urocanate hydratase; Provisional; Region: PRK05414 1064551002425 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1064551002426 active sites [active] 1064551002427 tetramer interface [polypeptide binding]; other site 1064551002428 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1064551002429 substrate binding site [chemical binding]; other site 1064551002430 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 1064551002431 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1064551002432 inhibitor-cofactor binding pocket; inhibition site 1064551002433 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551002434 catalytic residue [active] 1064551002435 biotin synthase; Provisional; Region: PRK15108 1064551002436 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064551002437 FeS/SAM binding site; other site 1064551002438 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1064551002439 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1064551002440 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1064551002441 substrate-cofactor binding pocket; other site 1064551002442 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551002443 catalytic residue [active] 1064551002444 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1064551002445 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064551002446 S-adenosylmethionine binding site [chemical binding]; other site 1064551002447 AAA domain; Region: AAA_26; pfam13500 1064551002448 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1064551002449 excinuclease ABC subunit B; Provisional; Region: PRK05298 1064551002450 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1064551002451 ATP binding site [chemical binding]; other site 1064551002452 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1064551002453 nucleotide binding region [chemical binding]; other site 1064551002454 ATP-binding site [chemical binding]; other site 1064551002455 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1064551002456 UvrB/uvrC motif; Region: UVR; pfam02151 1064551002457 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 1064551002458 pathogenicity island 2 effector protein SseI; Provisional; Region: PRK15372 1064551002459 Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468 1064551002460 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1064551002461 Leucine-rich repeats; other site 1064551002462 Substrate binding site [chemical binding]; other site 1064551002463 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1064551002464 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1064551002465 putative substrate binding pocket [chemical binding]; other site 1064551002466 dimer interface [polypeptide binding]; other site 1064551002467 phosphate binding site [ion binding]; other site 1064551002468 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1064551002469 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064551002470 FeS/SAM binding site; other site 1064551002471 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1064551002472 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1064551002473 MPT binding site; other site 1064551002474 trimer interface [polypeptide binding]; other site 1064551002475 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1064551002476 trimer interface [polypeptide binding]; other site 1064551002477 dimer interface [polypeptide binding]; other site 1064551002478 putative active site [active] 1064551002479 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1064551002480 MoaE interaction surface [polypeptide binding]; other site 1064551002481 MoeB interaction surface [polypeptide binding]; other site 1064551002482 thiocarboxylated glycine; other site 1064551002483 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1064551002484 MoaE homodimer interface [polypeptide binding]; other site 1064551002485 MoaD interaction [polypeptide binding]; other site 1064551002486 active site residues [active] 1064551002487 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1064551002488 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1064551002489 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1064551002490 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1064551002491 Predicted integral membrane protein [Function unknown]; Region: COG0392 1064551002492 cardiolipin synthase 2; Provisional; Region: PRK11263 1064551002493 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1064551002494 putative active site [active] 1064551002495 catalytic site [active] 1064551002496 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1064551002497 putative active site [active] 1064551002498 catalytic site [active] 1064551002499 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 1064551002500 putative catalytic site [active] 1064551002501 putative metal binding site [ion binding]; other site 1064551002502 putative phosphate binding site [ion binding]; other site 1064551002503 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 1064551002504 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1064551002505 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1064551002506 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1064551002507 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1064551002508 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1064551002509 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1064551002510 Walker A/P-loop; other site 1064551002511 ATP binding site [chemical binding]; other site 1064551002512 Q-loop/lid; other site 1064551002513 ABC transporter signature motif; other site 1064551002514 Walker B; other site 1064551002515 D-loop; other site 1064551002516 H-loop/switch region; other site 1064551002517 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1064551002518 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1064551002519 Walker A/P-loop; other site 1064551002520 ATP binding site [chemical binding]; other site 1064551002521 Q-loop/lid; other site 1064551002522 ABC transporter signature motif; other site 1064551002523 Walker B; other site 1064551002524 D-loop; other site 1064551002525 H-loop/switch region; other site 1064551002526 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1064551002527 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1064551002528 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064551002529 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 1064551002530 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1064551002531 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1064551002532 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1064551002533 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1064551002534 ATP binding site [chemical binding]; other site 1064551002535 Mg++ binding site [ion binding]; other site 1064551002536 motif III; other site 1064551002537 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1064551002538 nucleotide binding region [chemical binding]; other site 1064551002539 ATP-binding site [chemical binding]; other site 1064551002540 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 1064551002541 DEAD_2; Region: DEAD_2; pfam06733 1064551002542 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1064551002543 glycosyl transferase family protein; Provisional; Region: PRK08136 1064551002544 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1064551002545 hypothetical protein; Provisional; Region: PRK10259 1064551002546 hypothetical protein; Provisional; Region: PRK11019 1064551002547 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 1064551002548 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 1064551002549 putative mechanosensitive channel protein; Provisional; Region: PRK11465 1064551002550 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1064551002551 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 1064551002552 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1064551002553 Walker A/P-loop; other site 1064551002554 ATP binding site [chemical binding]; other site 1064551002555 Q-loop/lid; other site 1064551002556 ABC transporter signature motif; other site 1064551002557 Walker B; other site 1064551002558 D-loop; other site 1064551002559 H-loop/switch region; other site 1064551002560 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1064551002561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551002562 dimer interface [polypeptide binding]; other site 1064551002563 conserved gate region; other site 1064551002564 putative PBP binding loops; other site 1064551002565 ABC-ATPase subunit interface; other site 1064551002566 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 1064551002567 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064551002568 substrate binding pocket [chemical binding]; other site 1064551002569 membrane-bound complex binding site; other site 1064551002570 hinge residues; other site 1064551002571 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1064551002572 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1064551002573 dimerization interface [polypeptide binding]; other site 1064551002574 DPS ferroxidase diiron center [ion binding]; other site 1064551002575 ion pore; other site 1064551002576 threonine and homoserine efflux system; Provisional; Region: PRK10532 1064551002577 EamA-like transporter family; Region: EamA; pfam00892 1064551002578 outer membrane protein X; Provisional; Region: ompX; PRK09408 1064551002579 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1064551002580 Sulfatase; Region: Sulfatase; pfam00884 1064551002581 manganese transport regulator MntR; Provisional; Region: PRK11050 1064551002582 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1064551002583 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1064551002584 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 1064551002585 transmembrane helices; other site 1064551002586 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1064551002587 L,D-transpeptidase; Provisional; Region: PRK10260 1064551002588 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1064551002589 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1064551002590 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1064551002591 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064551002592 Walker A/P-loop; other site 1064551002593 ATP binding site [chemical binding]; other site 1064551002594 ABC transporter signature motif; other site 1064551002595 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1064551002596 Walker B; other site 1064551002597 ABC transporter; Region: ABC_tran_2; pfam12848 1064551002598 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1064551002599 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 1064551002600 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064551002601 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 1064551002602 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1064551002603 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064551002604 active site 1064551002605 motif I; other site 1064551002606 motif II; other site 1064551002607 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064551002608 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 1064551002609 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1064551002610 dimer interface [polypeptide binding]; other site 1064551002611 active site 1064551002612 glycine loop; other site 1064551002613 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 1064551002614 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064551002615 FeS/SAM binding site; other site 1064551002616 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1064551002617 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1064551002618 ATP binding site [chemical binding]; other site 1064551002619 substrate interface [chemical binding]; other site 1064551002620 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 1064551002621 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1064551002622 dimer interface [polypeptide binding]; other site 1064551002623 putative functional site; other site 1064551002624 putative MPT binding site; other site 1064551002625 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 1064551002626 catalytic nucleophile [active] 1064551002627 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1064551002628 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1064551002629 Walker A/P-loop; other site 1064551002630 ATP binding site [chemical binding]; other site 1064551002631 Q-loop/lid; other site 1064551002632 ABC transporter signature motif; other site 1064551002633 Walker B; other site 1064551002634 D-loop; other site 1064551002635 H-loop/switch region; other site 1064551002636 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1064551002637 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1064551002638 Walker A/P-loop; other site 1064551002639 ATP binding site [chemical binding]; other site 1064551002640 Q-loop/lid; other site 1064551002641 ABC transporter signature motif; other site 1064551002642 Walker B; other site 1064551002643 D-loop; other site 1064551002644 H-loop/switch region; other site 1064551002645 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1064551002646 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 1064551002647 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 1064551002648 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 1064551002649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551002650 dimer interface [polypeptide binding]; other site 1064551002651 conserved gate region; other site 1064551002652 putative PBP binding loops; other site 1064551002653 ABC-ATPase subunit interface; other site 1064551002654 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 1064551002655 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1064551002656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551002657 dimer interface [polypeptide binding]; other site 1064551002658 conserved gate region; other site 1064551002659 putative PBP binding loops; other site 1064551002660 ABC-ATPase subunit interface; other site 1064551002661 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1064551002662 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1064551002663 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064551002664 FeS/SAM binding site; other site 1064551002665 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 1064551002666 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1064551002667 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1064551002668 Ligand binding site [chemical binding]; other site 1064551002669 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1064551002670 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1064551002671 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1064551002672 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1064551002673 Uncharacterized conserved protein [Function unknown]; Region: COG3777 1064551002674 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1064551002675 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1064551002676 active site 1064551002677 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1064551002678 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1064551002679 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 1064551002680 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 1064551002681 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064551002682 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551002683 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 1064551002684 putative dimerization interface [polypeptide binding]; other site 1064551002685 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1064551002686 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1064551002687 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 1064551002688 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 1064551002689 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1064551002690 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1064551002691 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1064551002692 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1064551002693 putative C-terminal domain interface [polypeptide binding]; other site 1064551002694 putative GSH binding site (G-site) [chemical binding]; other site 1064551002695 putative dimer interface [polypeptide binding]; other site 1064551002696 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1064551002697 putative N-terminal domain interface [polypeptide binding]; other site 1064551002698 putative dimer interface [polypeptide binding]; other site 1064551002699 putative substrate binding pocket (H-site) [chemical binding]; other site 1064551002700 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 1064551002701 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1064551002702 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1064551002703 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 1064551002704 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1064551002705 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1064551002706 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1064551002707 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1064551002708 active site 1064551002709 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 1064551002710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551002711 putative substrate translocation pore; other site 1064551002712 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1064551002713 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064551002714 active site 1064551002715 motif I; other site 1064551002716 motif II; other site 1064551002717 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064551002718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551002719 putative substrate translocation pore; other site 1064551002720 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1064551002721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1064551002722 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1064551002723 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1064551002724 putative transporter; Provisional; Region: PRK04972 1064551002725 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1064551002726 TrkA-C domain; Region: TrkA_C; pfam02080 1064551002727 TrkA-C domain; Region: TrkA_C; pfam02080 1064551002728 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1064551002729 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 1064551002730 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 1064551002731 GSH binding site [chemical binding]; other site 1064551002732 catalytic residues [active] 1064551002733 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 1064551002734 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1064551002735 dimer interface [polypeptide binding]; other site 1064551002736 FMN binding site [chemical binding]; other site 1064551002737 NADPH bind site [chemical binding]; other site 1064551002738 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1064551002739 RimK-like ATP-grasp domain; Region: RimK; pfam08443 1064551002740 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1064551002741 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1064551002742 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1064551002743 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 1064551002744 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064551002745 Walker A/P-loop; other site 1064551002746 ATP binding site [chemical binding]; other site 1064551002747 Q-loop/lid; other site 1064551002748 ABC transporter signature motif; other site 1064551002749 Walker B; other site 1064551002750 D-loop; other site 1064551002751 H-loop/switch region; other site 1064551002752 TOBE domain; Region: TOBE_2; pfam08402 1064551002753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551002754 dimer interface [polypeptide binding]; other site 1064551002755 conserved gate region; other site 1064551002756 putative PBP binding loops; other site 1064551002757 ABC-ATPase subunit interface; other site 1064551002758 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1064551002759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551002760 dimer interface [polypeptide binding]; other site 1064551002761 conserved gate region; other site 1064551002762 putative PBP binding loops; other site 1064551002763 ABC-ATPase subunit interface; other site 1064551002764 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 1064551002765 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 1064551002766 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064551002767 S-adenosylmethionine binding site [chemical binding]; other site 1064551002768 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 1064551002769 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1064551002770 active site 1064551002771 P-loop; other site 1064551002772 phosphorylation site [posttranslational modification] 1064551002773 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1064551002774 Sulfatase; Region: Sulfatase; cl17466 1064551002775 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1064551002776 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064551002777 substrate binding pocket [chemical binding]; other site 1064551002778 membrane-bound complex binding site; other site 1064551002779 hinge residues; other site 1064551002780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551002781 dimer interface [polypeptide binding]; other site 1064551002782 conserved gate region; other site 1064551002783 putative PBP binding loops; other site 1064551002784 ABC-ATPase subunit interface; other site 1064551002785 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1064551002786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551002787 dimer interface [polypeptide binding]; other site 1064551002788 conserved gate region; other site 1064551002789 putative PBP binding loops; other site 1064551002790 ABC-ATPase subunit interface; other site 1064551002791 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1064551002792 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064551002793 substrate binding pocket [chemical binding]; other site 1064551002794 membrane-bound complex binding site; other site 1064551002795 hinge residues; other site 1064551002796 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 1064551002797 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064551002798 Walker A/P-loop; other site 1064551002799 ATP binding site [chemical binding]; other site 1064551002800 Q-loop/lid; other site 1064551002801 ABC transporter signature motif; other site 1064551002802 Walker B; other site 1064551002803 D-loop; other site 1064551002804 H-loop/switch region; other site 1064551002805 putative lipoprotein; Provisional; Region: PRK10533 1064551002806 hypothetical protein; Provisional; Region: PRK02877 1064551002807 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1064551002808 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1064551002809 amidase catalytic site [active] 1064551002810 Zn binding residues [ion binding]; other site 1064551002811 substrate binding site [chemical binding]; other site 1064551002812 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1064551002813 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064551002814 NAD(P) binding site [chemical binding]; other site 1064551002815 active site 1064551002816 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1064551002817 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 1064551002818 putative NAD(P) binding site [chemical binding]; other site 1064551002819 putative active site [active] 1064551002820 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1064551002821 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1064551002822 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1064551002823 tetramer interface [polypeptide binding]; other site 1064551002824 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551002825 catalytic residue [active] 1064551002826 pyruvate dehydrogenase; Provisional; Region: PRK09124 1064551002827 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1064551002828 PYR/PP interface [polypeptide binding]; other site 1064551002829 dimer interface [polypeptide binding]; other site 1064551002830 tetramer interface [polypeptide binding]; other site 1064551002831 TPP binding site [chemical binding]; other site 1064551002832 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1064551002833 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1064551002834 TPP-binding site [chemical binding]; other site 1064551002835 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 1064551002836 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1064551002837 FAD binding pocket [chemical binding]; other site 1064551002838 FAD binding motif [chemical binding]; other site 1064551002839 phosphate binding motif [ion binding]; other site 1064551002840 beta-alpha-beta structure motif; other site 1064551002841 NAD binding pocket [chemical binding]; other site 1064551002842 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1064551002843 catalytic loop [active] 1064551002844 iron binding site [ion binding]; other site 1064551002845 hybrid cluster protein; Provisional; Region: PRK05290 1064551002846 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1064551002847 ACS interaction site; other site 1064551002848 CODH interaction site; other site 1064551002849 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 1064551002850 hybrid metal cluster; other site 1064551002851 Predicted membrane protein [Function unknown]; Region: COG2431 1064551002852 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1064551002853 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 1064551002854 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1064551002855 putative active site [active] 1064551002856 putative metal-binding site [ion binding]; other site 1064551002857 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 1064551002858 macrolide transporter subunit MacA; Provisional; Region: PRK11578 1064551002859 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1064551002860 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064551002861 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1064551002862 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1064551002863 Walker A/P-loop; other site 1064551002864 ATP binding site [chemical binding]; other site 1064551002865 Q-loop/lid; other site 1064551002866 ABC transporter signature motif; other site 1064551002867 Walker B; other site 1064551002868 D-loop; other site 1064551002869 H-loop/switch region; other site 1064551002870 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1064551002871 FtsX-like permease family; Region: FtsX; pfam02687 1064551002872 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1064551002873 DNA-binding site [nucleotide binding]; DNA binding site 1064551002874 RNA-binding motif; other site 1064551002875 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1064551002876 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 1064551002877 Clp amino terminal domain; Region: Clp_N; pfam02861 1064551002878 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064551002879 Walker A motif; other site 1064551002880 ATP binding site [chemical binding]; other site 1064551002881 Walker B motif; other site 1064551002882 arginine finger; other site 1064551002883 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064551002884 Walker A motif; other site 1064551002885 ATP binding site [chemical binding]; other site 1064551002886 Walker B motif; other site 1064551002887 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1064551002888 Isochorismatase family; Region: Isochorismatase; pfam00857 1064551002889 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1064551002890 catalytic triad [active] 1064551002891 dimer interface [polypeptide binding]; other site 1064551002892 conserved cis-peptide bond; other site 1064551002893 Pirin-related protein [General function prediction only]; Region: COG1741 1064551002894 Pirin; Region: Pirin; pfam02678 1064551002895 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1064551002896 LysR family transcriptional regulator; Provisional; Region: PRK14997 1064551002897 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551002898 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 1064551002899 putative effector binding pocket; other site 1064551002900 putative dimerization interface [polypeptide binding]; other site 1064551002901 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1064551002902 rRNA binding site [nucleotide binding]; other site 1064551002903 predicted 30S ribosome binding site; other site 1064551002904 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1064551002905 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 1064551002906 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1064551002907 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064551002908 Walker A/P-loop; other site 1064551002909 ATP binding site [chemical binding]; other site 1064551002910 Q-loop/lid; other site 1064551002911 ABC transporter signature motif; other site 1064551002912 Walker B; other site 1064551002913 D-loop; other site 1064551002914 H-loop/switch region; other site 1064551002915 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 1064551002916 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1064551002917 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064551002918 Walker A/P-loop; other site 1064551002919 ATP binding site [chemical binding]; other site 1064551002920 Q-loop/lid; other site 1064551002921 ABC transporter signature motif; other site 1064551002922 Walker B; other site 1064551002923 D-loop; other site 1064551002924 H-loop/switch region; other site 1064551002925 thioredoxin reductase; Provisional; Region: PRK10262 1064551002926 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1064551002927 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1064551002928 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1064551002929 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1064551002930 putative DNA binding site [nucleotide binding]; other site 1064551002931 putative Zn2+ binding site [ion binding]; other site 1064551002932 AsnC family; Region: AsnC_trans_reg; pfam01037 1064551002933 DNA translocase FtsK; Provisional; Region: PRK10263 1064551002934 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1064551002935 DNA translocase FtsK; Provisional; Region: PRK10263 1064551002936 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1064551002937 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1064551002938 periplasmic chaperone LolA; Region: lolA; TIGR00547 1064551002939 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1064551002940 recombination factor protein RarA; Reviewed; Region: PRK13342 1064551002941 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064551002942 Walker A motif; other site 1064551002943 ATP binding site [chemical binding]; other site 1064551002944 Walker B motif; other site 1064551002945 arginine finger; other site 1064551002946 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1064551002947 seryl-tRNA synthetase; Provisional; Region: PRK05431 1064551002948 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1064551002949 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1064551002950 dimer interface [polypeptide binding]; other site 1064551002951 active site 1064551002952 motif 1; other site 1064551002953 motif 2; other site 1064551002954 motif 3; other site 1064551002955 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 1064551002956 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1064551002957 putative [Fe4-S4] binding site [ion binding]; other site 1064551002958 putative molybdopterin cofactor binding site [chemical binding]; other site 1064551002959 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1064551002960 putative molybdopterin cofactor binding site; other site 1064551002961 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1064551002962 4Fe-4S binding domain; Region: Fer4; pfam00037 1064551002963 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 1064551002964 putative MFS family transporter protein; Provisional; Region: PRK03633 1064551002965 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551002966 putative substrate translocation pore; other site 1064551002967 inner membrane transporter YjeM; Provisional; Region: PRK15238 1064551002968 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 1064551002969 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064551002970 FeS/SAM binding site; other site 1064551002971 integrase; Provisional; Region: int; PHA02601 1064551002972 pathogenicity island 1 protein SopD2; Provisional; Region: PRK15380 1064551002973 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1064551002974 Pyruvate formate lyase 1; Region: PFL1; cd01678 1064551002975 coenzyme A binding site [chemical binding]; other site 1064551002976 active site 1064551002977 catalytic residues [active] 1064551002978 glycine loop; other site 1064551002979 formate transporter; Provisional; Region: PRK10805 1064551002980 uncharacterized domain; Region: TIGR00702 1064551002981 YcaO-like family; Region: YcaO; pfam02624 1064551002982 Predicted membrane protein [Function unknown]; Region: COG2323 1064551002983 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1064551002984 homodimer interface [polypeptide binding]; other site 1064551002985 substrate-cofactor binding pocket; other site 1064551002986 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551002987 catalytic residue [active] 1064551002988 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1064551002989 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 1064551002990 putative active site [active] 1064551002991 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1064551002992 cytidylate kinase; Provisional; Region: cmk; PRK00023 1064551002993 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1064551002994 CMP-binding site; other site 1064551002995 The sites determining sugar specificity; other site 1064551002996 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1064551002997 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1064551002998 RNA binding site [nucleotide binding]; other site 1064551002999 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1064551003000 RNA binding site [nucleotide binding]; other site 1064551003001 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 1064551003002 RNA binding site [nucleotide binding]; other site 1064551003003 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 1064551003004 RNA binding site [nucleotide binding]; other site 1064551003005 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1064551003006 RNA binding site [nucleotide binding]; other site 1064551003007 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1064551003008 IHF dimer interface [polypeptide binding]; other site 1064551003009 IHF - DNA interface [nucleotide binding]; other site 1064551003010 ComEC family competence protein; Provisional; Region: PRK11539 1064551003011 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1064551003012 Competence protein; Region: Competence; pfam03772 1064551003013 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1064551003014 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 1064551003015 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1064551003016 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1064551003017 Walker A/P-loop; other site 1064551003018 ATP binding site [chemical binding]; other site 1064551003019 Q-loop/lid; other site 1064551003020 ABC transporter signature motif; other site 1064551003021 Walker B; other site 1064551003022 D-loop; other site 1064551003023 H-loop/switch region; other site 1064551003024 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1064551003025 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 1064551003026 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1064551003027 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1064551003028 hypothetical protein; Provisional; Region: PRK11827 1064551003029 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1064551003030 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1064551003031 Ligand binding site; other site 1064551003032 oligomer interface; other site 1064551003033 hypothetical protein; Provisional; Region: PRK10593 1064551003034 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1064551003035 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1064551003036 putative active site [active] 1064551003037 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1064551003038 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064551003039 S-adenosylmethionine binding site [chemical binding]; other site 1064551003040 condesin subunit F; Provisional; Region: PRK05260 1064551003041 condesin subunit E; Provisional; Region: PRK05256 1064551003042 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 1064551003043 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1064551003044 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1064551003045 murein L,D-transpeptidase; Provisional; Region: PRK10594 1064551003046 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1064551003047 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1064551003048 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1064551003049 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 1064551003050 Peptidase M15; Region: Peptidase_M15_3; cl01194 1064551003051 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1064551003052 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1064551003053 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1064551003054 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551003055 homodimer interface [polypeptide binding]; other site 1064551003056 catalytic residue [active] 1064551003057 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1064551003058 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1064551003059 trimer interface [polypeptide binding]; other site 1064551003060 eyelet of channel; other site 1064551003061 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1064551003062 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1064551003063 putative dimer interface [polypeptide binding]; other site 1064551003064 putative anticodon binding site; other site 1064551003065 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1064551003066 homodimer interface [polypeptide binding]; other site 1064551003067 motif 1; other site 1064551003068 motif 2; other site 1064551003069 active site 1064551003070 motif 3; other site 1064551003071 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1064551003072 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1064551003073 putative DNA binding site [nucleotide binding]; other site 1064551003074 putative Zn2+ binding site [ion binding]; other site 1064551003075 AsnC family; Region: AsnC_trans_reg; pfam01037 1064551003076 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1064551003077 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 1064551003078 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1064551003079 catalytic residue [active] 1064551003080 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1064551003081 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1064551003082 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 1064551003083 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 1064551003084 active site 1064551003085 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 1064551003086 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1064551003087 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 1064551003088 Int/Topo IB signature motif; other site 1064551003089 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 1064551003090 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 1064551003091 RecT family; Region: RecT; pfam03837 1064551003092 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 1064551003093 exonuclease VIII; Reviewed; Region: PRK09709 1064551003094 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 1064551003095 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064551003096 transcriptional repressor DicA; Reviewed; Region: PRK09706 1064551003097 non-specific DNA binding site [nucleotide binding]; other site 1064551003098 salt bridge; other site 1064551003099 sequence-specific DNA binding site [nucleotide binding]; other site 1064551003100 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 1064551003101 Bacteriophage CII protein; Region: Phage_CII; pfam05269 1064551003102 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 1064551003103 primosomal protein DnaI; Provisional; Region: PRK02854 1064551003104 putative replication protein; Provisional; Region: PRK12377 1064551003105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064551003106 ATP binding site [chemical binding]; other site 1064551003107 Walker A motif; other site 1064551003108 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 1064551003109 DinI-like family; Region: DinI; pfam06183 1064551003110 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 1064551003111 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 1064551003112 Antitermination protein; Region: Antiterm; pfam03589 1064551003113 Antitermination protein; Region: Antiterm; pfam03589 1064551003114 phage holin, lambda family; Region: holin_lambda; TIGR01594 1064551003115 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1064551003116 catalytic residues [active] 1064551003117 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 1064551003118 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1064551003119 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 1064551003120 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 1064551003121 gpW; Region: gpW; pfam02831 1064551003122 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 1064551003123 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 1064551003124 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 1064551003125 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1064551003126 tandem repeat interface [polypeptide binding]; other site 1064551003127 oligomer interface [polypeptide binding]; other site 1064551003128 active site residues [active] 1064551003129 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 1064551003130 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 1064551003131 DNA packaging protein FI; Region: Packaging_FI; pfam14000 1064551003132 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 1064551003133 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 1064551003134 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 1064551003135 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1064551003136 Phage tail protein; Region: Phage_tail_3; pfam08813 1064551003137 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 1064551003138 Minor tail protein T; Region: Phage_tail_T; pfam06223 1064551003139 Phage-related minor tail protein [Function unknown]; Region: COG5281 1064551003140 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 1064551003141 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 1064551003142 Phage-related protein [Function unknown]; Region: COG4718 1064551003143 Phage-related protein [Function unknown]; Region: gp18; COG4672 1064551003144 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 1064551003145 MPN+ (JAMM) motif; other site 1064551003146 Zinc-binding site [ion binding]; other site 1064551003147 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1064551003148 NlpC/P60 family; Region: NLPC_P60; cl17555 1064551003149 Phage-related protein, tail component [Function unknown]; Region: COG4723 1064551003150 Phage-related protein, tail component [Function unknown]; Region: COG4733 1064551003151 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1064551003152 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1064551003153 Interdomain contacts; other site 1064551003154 Cytokine receptor motif; other site 1064551003155 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 1064551003156 Fibronectin type III protein; Region: DUF3672; pfam12421 1064551003157 Phage Tail Collar Domain; Region: Collar; pfam07484 1064551003158 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1064551003159 type III secretion protein GogB; Provisional; Region: PRK15386 1064551003160 DinI-like family; Region: DinI; cl11630 1064551003161 aminopeptidase N; Provisional; Region: pepN; PRK14015 1064551003162 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1064551003163 active site 1064551003164 Zn binding site [ion binding]; other site 1064551003165 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1064551003166 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1064551003167 quinone interaction residues [chemical binding]; other site 1064551003168 active site 1064551003169 catalytic residues [active] 1064551003170 FMN binding site [chemical binding]; other site 1064551003171 substrate binding site [chemical binding]; other site 1064551003172 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 1064551003173 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1064551003174 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1064551003175 MOSC domain; Region: MOSC; pfam03473 1064551003176 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1064551003177 catalytic loop [active] 1064551003178 iron binding site [ion binding]; other site 1064551003179 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1064551003180 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1064551003181 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 1064551003182 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064551003183 S-adenosylmethionine binding site [chemical binding]; other site 1064551003184 ABC transporter ATPase component; Reviewed; Region: PRK11147 1064551003185 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064551003186 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064551003187 Walker A/P-loop; other site 1064551003188 Walker A/P-loop; other site 1064551003189 ATP binding site [chemical binding]; other site 1064551003190 ATP binding site [chemical binding]; other site 1064551003191 Q-loop/lid; other site 1064551003192 Q-loop/lid; other site 1064551003193 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1064551003194 ABC transporter signature motif; other site 1064551003195 Walker B; other site 1064551003196 D-loop; other site 1064551003197 ABC transporter; Region: ABC_tran_2; pfam12848 1064551003198 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1064551003199 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 1064551003200 Paraquat-inducible protein A; Region: PqiA; pfam04403 1064551003201 Paraquat-inducible protein A; Region: PqiA; pfam04403 1064551003202 paraquat-inducible protein B; Provisional; Region: PRK10807 1064551003203 mce related protein; Region: MCE; pfam02470 1064551003204 mce related protein; Region: MCE; pfam02470 1064551003205 mce related protein; Region: MCE; pfam02470 1064551003206 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 1064551003207 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1064551003208 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1064551003209 active site 1 [active] 1064551003210 dimer interface [polypeptide binding]; other site 1064551003211 active site 2 [active] 1064551003212 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 1064551003213 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1064551003214 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 1064551003215 outer membrane protein A; Reviewed; Region: PRK10808 1064551003216 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 1064551003217 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1064551003218 ligand binding site [chemical binding]; other site 1064551003219 Cell division inhibitor SulA; Region: SulA; cl01880 1064551003220 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 1064551003221 TfoX C-terminal domain; Region: TfoX_C; pfam04994 1064551003222 TIGR01666 family membrane protein; Region: YCCS 1064551003223 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1064551003224 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1064551003225 Predicted membrane protein [Function unknown]; Region: COG3304 1064551003226 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1064551003227 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1064551003228 DNA helicase IV; Provisional; Region: helD; PRK11054 1064551003229 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 1064551003230 Part of AAA domain; Region: AAA_19; pfam13245 1064551003231 Family description; Region: UvrD_C_2; pfam13538 1064551003232 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1064551003233 active site 1064551003234 dimer interfaces [polypeptide binding]; other site 1064551003235 catalytic residues [active] 1064551003236 hypothetical protein; Provisional; Region: PRK03641 1064551003237 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 1064551003238 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1064551003239 heat shock protein HspQ; Provisional; Region: PRK14129 1064551003240 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 1064551003241 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 1064551003242 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1064551003243 putative RNA binding site [nucleotide binding]; other site 1064551003244 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064551003245 S-adenosylmethionine binding site [chemical binding]; other site 1064551003246 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1064551003247 substrate binding site [chemical binding]; other site 1064551003248 Cupin domain; Region: Cupin_2; cl17218 1064551003249 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1064551003250 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064551003251 acylphosphatase; Provisional; Region: PRK14426 1064551003252 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1064551003253 sulfur transfer protein TusE; Provisional; Region: PRK11508 1064551003254 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1064551003255 YccA-like proteins; Region: YccA_like; cd10433 1064551003256 secreted effector protein PipB; Provisional; Region: PRK15197 1064551003257 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064551003258 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064551003259 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064551003260 type III secretion chaperone protein SigE; Provisional; Region: PRK15202 1064551003261 inositol phosphate phosphatase SopB; Provisional; Region: PRK15378 1064551003262 Enterobacterial virulence protein IpgD; Region: IpgD; pfam05925 1064551003263 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 1064551003264 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 1064551003265 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1064551003266 HAMP domain; Region: HAMP; pfam00672 1064551003267 dimerization interface [polypeptide binding]; other site 1064551003268 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064551003269 dimer interface [polypeptide binding]; other site 1064551003270 phosphorylation site [posttranslational modification] 1064551003271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064551003272 ATP binding site [chemical binding]; other site 1064551003273 Mg2+ binding site [ion binding]; other site 1064551003274 G-X-G motif; other site 1064551003275 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 1064551003276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064551003277 active site 1064551003278 phosphorylation site [posttranslational modification] 1064551003279 intermolecular recognition site; other site 1064551003280 dimerization interface [polypeptide binding]; other site 1064551003281 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1064551003282 DNA binding site [nucleotide binding] 1064551003283 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1064551003284 active site 1064551003285 homotetramer interface [polypeptide binding]; other site 1064551003286 4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486 1064551003287 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 1064551003288 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1064551003289 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 1064551003290 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1064551003291 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203 1064551003292 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1064551003293 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1064551003294 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 1064551003295 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1064551003296 NAD binding site [chemical binding]; other site 1064551003297 catalytic residues [active] 1064551003298 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 1064551003299 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1064551003300 putative active site [active] 1064551003301 putative metal binding site [ion binding]; other site 1064551003302 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 1064551003303 putative substrate binding pocket [chemical binding]; other site 1064551003304 trimer interface [polypeptide binding]; other site 1064551003305 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 1064551003306 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1064551003307 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551003308 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1064551003309 putative substrate translocation pore; other site 1064551003310 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 1064551003311 Cupin domain; Region: Cupin_2; pfam07883 1064551003312 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064551003313 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1064551003314 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 1064551003315 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 1064551003316 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1064551003317 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1064551003318 HSP70 interaction site [polypeptide binding]; other site 1064551003319 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1064551003320 substrate binding site [polypeptide binding]; other site 1064551003321 dimer interface [polypeptide binding]; other site 1064551003322 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 1064551003323 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1064551003324 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1064551003325 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1064551003326 DsbD alpha interface [polypeptide binding]; other site 1064551003327 catalytic residues [active] 1064551003328 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 1064551003329 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 1064551003330 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1064551003331 catalytic residues [active] 1064551003332 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 1064551003333 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1064551003334 catalytic residues [active] 1064551003335 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 1064551003336 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1064551003337 catalytic core [active] 1064551003338 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1064551003339 hypothetical protein; Provisional; Region: PRK10174 1064551003340 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 1064551003341 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1064551003342 General stress protein [General function prediction only]; Region: GsiB; COG3729 1064551003343 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 1064551003344 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1064551003345 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1064551003346 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 1064551003347 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 1064551003348 Predicted transcriptional regulator [Transcription]; Region: COG3905 1064551003349 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1064551003350 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1064551003351 Glutamate binding site [chemical binding]; other site 1064551003352 NAD binding site [chemical binding]; other site 1064551003353 catalytic residues [active] 1064551003354 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1064551003355 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1064551003356 Na binding site [ion binding]; other site 1064551003357 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1064551003358 hypothetical protein; Provisional; Region: PRK10536 1064551003359 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1064551003360 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1064551003361 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1064551003362 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1064551003363 putative active site [active] 1064551003364 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 1064551003365 Na binding site [ion binding]; other site 1064551003366 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 1064551003367 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1064551003368 putative active site cavity [active] 1064551003369 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 1064551003370 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 1064551003371 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178 1064551003372 putative sialic acid transporter; Provisional; Region: PRK12307 1064551003373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551003374 putative substrate translocation pore; other site 1064551003375 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1064551003376 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1064551003377 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1064551003378 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 1064551003379 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1064551003380 putative ligand binding site [chemical binding]; other site 1064551003381 NAD binding site [chemical binding]; other site 1064551003382 dimerization interface [polypeptide binding]; other site 1064551003383 catalytic site [active] 1064551003384 putative hydrolase; Validated; Region: PRK09248 1064551003385 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 1064551003386 active site 1064551003387 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 1064551003388 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 1064551003389 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 1064551003390 curli assembly protein CsgF; Provisional; Region: PRK10050 1064551003391 curli assembly protein CsgE; Provisional; Region: PRK10386 1064551003392 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 1064551003393 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064551003394 DNA binding residues [nucleotide binding] 1064551003395 dimerization interface [polypeptide binding]; other site 1064551003396 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 1064551003397 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1064551003398 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1064551003399 major curlin subunit; Provisional; Region: csgA; PRK10051 1064551003400 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1064551003401 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 1064551003402 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1064551003403 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1064551003404 putative ADP-ribose binding site [chemical binding]; other site 1064551003405 putative active site [active] 1064551003406 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1064551003407 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 1064551003408 putative active site [active] 1064551003409 catalytic site [active] 1064551003410 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 1064551003411 putative active site [active] 1064551003412 catalytic site [active] 1064551003413 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1064551003414 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1064551003415 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 1064551003416 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 1064551003417 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1064551003418 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 1064551003419 Ligand binding site; other site 1064551003420 DXD motif; other site 1064551003421 lipoprotein; Provisional; Region: PRK10175 1064551003422 secY/secA suppressor protein; Provisional; Region: PRK11467 1064551003423 drug efflux system protein MdtG; Provisional; Region: PRK09874 1064551003424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551003425 putative substrate translocation pore; other site 1064551003426 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1064551003427 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1064551003428 putative acyl-acceptor binding pocket; other site 1064551003429 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1064551003430 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1064551003431 active site residue [active] 1064551003432 hypothetical protein; Provisional; Region: PRK03757 1064551003433 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1064551003434 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 1064551003435 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1064551003436 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1064551003437 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 1064551003438 DNA damage-inducible protein I; Provisional; Region: PRK10597 1064551003439 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1064551003440 active site 1064551003441 substrate binding pocket [chemical binding]; other site 1064551003442 dimer interface [polypeptide binding]; other site 1064551003443 lipoprotein; Provisional; Region: PRK10598 1064551003444 glutaredoxin 2; Provisional; Region: PRK10387 1064551003445 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 1064551003446 C-terminal domain interface [polypeptide binding]; other site 1064551003447 GSH binding site (G-site) [chemical binding]; other site 1064551003448 catalytic residues [active] 1064551003449 putative dimer interface [polypeptide binding]; other site 1064551003450 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 1064551003451 N-terminal domain interface [polypeptide binding]; other site 1064551003452 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1064551003453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551003454 putative substrate translocation pore; other site 1064551003455 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 1064551003456 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1064551003457 hypothetical protein; Provisional; Region: PRK11239 1064551003458 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 1064551003459 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1064551003460 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1064551003461 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1064551003462 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1064551003463 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1064551003464 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 1064551003465 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 1064551003466 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 1064551003467 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1064551003468 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1064551003469 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1064551003470 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1064551003471 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1064551003472 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1064551003473 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1064551003474 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 1064551003475 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1064551003476 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1064551003477 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1064551003478 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1064551003479 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1064551003480 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1064551003481 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 1064551003482 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1064551003483 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1064551003484 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1064551003485 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1064551003486 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1064551003487 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 1064551003488 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 1064551003489 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1064551003490 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1064551003491 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 1064551003492 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 1064551003493 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1064551003494 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 1064551003495 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1064551003496 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 1064551003497 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1064551003498 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1064551003499 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1064551003500 homodimer interface [polypeptide binding]; other site 1064551003501 oligonucleotide binding site [chemical binding]; other site 1064551003502 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 1064551003503 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1064551003504 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1064551003505 RNA binding surface [nucleotide binding]; other site 1064551003506 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1064551003507 active site 1064551003508 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 1064551003509 Maf-like protein; Region: Maf; pfam02545 1064551003510 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1064551003511 active site 1064551003512 dimer interface [polypeptide binding]; other site 1064551003513 hypothetical protein; Provisional; Region: PRK11193 1064551003514 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1064551003515 putative phosphate acyltransferase; Provisional; Region: PRK05331 1064551003516 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1064551003517 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1064551003518 dimer interface [polypeptide binding]; other site 1064551003519 active site 1064551003520 CoA binding pocket [chemical binding]; other site 1064551003521 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1064551003522 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1064551003523 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1064551003524 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1064551003525 NAD(P) binding site [chemical binding]; other site 1064551003526 homotetramer interface [polypeptide binding]; other site 1064551003527 homodimer interface [polypeptide binding]; other site 1064551003528 active site 1064551003529 acyl carrier protein; Provisional; Region: acpP; PRK00982 1064551003530 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1064551003531 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1064551003532 dimer interface [polypeptide binding]; other site 1064551003533 active site 1064551003534 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1064551003535 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1064551003536 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551003537 catalytic residue [active] 1064551003538 conserved hypothetical protein, YceG family; Region: TIGR00247 1064551003539 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1064551003540 dimerization interface [polypeptide binding]; other site 1064551003541 thymidylate kinase; Validated; Region: tmk; PRK00698 1064551003542 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1064551003543 TMP-binding site; other site 1064551003544 ATP-binding site [chemical binding]; other site 1064551003545 DNA polymerase III subunit delta'; Validated; Region: PRK07993 1064551003546 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 1064551003547 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1064551003548 active site 1064551003549 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 1064551003550 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1064551003551 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1064551003552 active site turn [active] 1064551003553 phosphorylation site [posttranslational modification] 1064551003554 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 1064551003555 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1064551003556 N-terminal plug; other site 1064551003557 ligand-binding site [chemical binding]; other site 1064551003558 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1064551003559 nucleotide binding site/active site [active] 1064551003560 HIT family signature motif; other site 1064551003561 catalytic residue [active] 1064551003562 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 1064551003563 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 1064551003564 putative dimer interface [polypeptide binding]; other site 1064551003565 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 1064551003566 thiamine kinase; Region: ycfN_thiK; TIGR02721 1064551003567 thiamine kinase; Provisional; Region: thiK; PRK10271 1064551003568 substrate binding site [chemical binding]; other site 1064551003569 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1064551003570 beta-hexosaminidase; Provisional; Region: PRK05337 1064551003571 hypothetical protein; Provisional; Region: PRK04940 1064551003572 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1064551003573 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1064551003574 hypothetical protein; Provisional; Region: PRK11280 1064551003575 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1064551003576 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1064551003577 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1064551003578 L,D-transpeptidase; Provisional; Region: PRK10260 1064551003579 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1064551003580 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1064551003581 transcription-repair coupling factor; Provisional; Region: PRK10689 1064551003582 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1064551003583 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1064551003584 ATP binding site [chemical binding]; other site 1064551003585 putative Mg++ binding site [ion binding]; other site 1064551003586 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1064551003587 nucleotide binding region [chemical binding]; other site 1064551003588 ATP-binding site [chemical binding]; other site 1064551003589 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1064551003590 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 1064551003591 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1064551003592 FtsX-like permease family; Region: FtsX; pfam02687 1064551003593 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 1064551003594 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1064551003595 Walker A/P-loop; other site 1064551003596 ATP binding site [chemical binding]; other site 1064551003597 Q-loop/lid; other site 1064551003598 ABC transporter signature motif; other site 1064551003599 Walker B; other site 1064551003600 D-loop; other site 1064551003601 H-loop/switch region; other site 1064551003602 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 1064551003603 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1064551003604 FtsX-like permease family; Region: FtsX; pfam02687 1064551003605 fructokinase; Reviewed; Region: PRK09557 1064551003606 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1064551003607 nucleotide binding site [chemical binding]; other site 1064551003608 NAD-dependent deacetylase; Provisional; Region: PRK00481 1064551003609 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1064551003610 NAD+ binding site [chemical binding]; other site 1064551003611 substrate binding site [chemical binding]; other site 1064551003612 Zn binding site [ion binding]; other site 1064551003613 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 1064551003614 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1064551003615 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1064551003616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551003617 dimer interface [polypeptide binding]; other site 1064551003618 conserved gate region; other site 1064551003619 putative PBP binding loops; other site 1064551003620 ABC-ATPase subunit interface; other site 1064551003621 Sif protein; Region: Sif; pfam06767 1064551003622 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1064551003623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551003624 dimer interface [polypeptide binding]; other site 1064551003625 conserved gate region; other site 1064551003626 putative PBP binding loops; other site 1064551003627 ABC-ATPase subunit interface; other site 1064551003628 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 1064551003629 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064551003630 Walker A/P-loop; other site 1064551003631 ATP binding site [chemical binding]; other site 1064551003632 Q-loop/lid; other site 1064551003633 ABC transporter signature motif; other site 1064551003634 Walker B; other site 1064551003635 D-loop; other site 1064551003636 H-loop/switch region; other site 1064551003637 TOBE domain; Region: TOBE_2; pfam08402 1064551003638 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 1064551003639 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1064551003640 metal binding site [ion binding]; metal-binding site 1064551003641 dimer interface [polypeptide binding]; other site 1064551003642 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1064551003643 Cupin domain; Region: Cupin_2; cl17218 1064551003644 sensor protein PhoQ; Provisional; Region: PRK10815 1064551003645 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 1064551003646 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1064551003647 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064551003648 ATP binding site [chemical binding]; other site 1064551003649 Mg2+ binding site [ion binding]; other site 1064551003650 G-X-G motif; other site 1064551003651 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 1064551003652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064551003653 active site 1064551003654 phosphorylation site [posttranslational modification] 1064551003655 intermolecular recognition site; other site 1064551003656 dimerization interface [polypeptide binding]; other site 1064551003657 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1064551003658 DNA binding site [nucleotide binding] 1064551003659 adenylosuccinate lyase; Provisional; Region: PRK09285 1064551003660 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1064551003661 tetramer interface [polypeptide binding]; other site 1064551003662 active site 1064551003663 putative lysogenization regulator; Reviewed; Region: PRK00218 1064551003664 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1064551003665 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 1064551003666 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 1064551003667 nudix motif; other site 1064551003668 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 1064551003669 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1064551003670 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 1064551003671 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 1064551003672 probable active site [active] 1064551003673 isocitrate dehydrogenase; Validated; Region: PRK07362 1064551003674 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1064551003675 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 1064551003676 DinI-like family; Region: DinI; pfam06183 1064551003677 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1064551003678 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1064551003679 putative sugar binding sites [chemical binding]; other site 1064551003680 Q-X-W motif; other site 1064551003681 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1064551003682 DNA-binding site [nucleotide binding]; DNA binding site 1064551003683 RNA-binding motif; other site 1064551003684 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1064551003685 lysozyme inhibitor; Provisional; Region: PRK13791 1064551003686 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1064551003687 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1064551003688 putative dimer interface [polypeptide binding]; other site 1064551003689 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 1064551003690 BNR repeat-like domain; Region: BNR_2; pfam13088 1064551003691 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1064551003692 TRL-like protein family; Region: TRL; pfam13146 1064551003693 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 1064551003694 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1064551003695 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1064551003696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551003697 dimer interface [polypeptide binding]; other site 1064551003698 conserved gate region; other site 1064551003699 ABC-ATPase subunit interface; other site 1064551003700 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1064551003701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551003702 dimer interface [polypeptide binding]; other site 1064551003703 conserved gate region; other site 1064551003704 putative PBP binding loops; other site 1064551003705 ABC-ATPase subunit interface; other site 1064551003706 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1064551003707 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1064551003708 Walker A/P-loop; other site 1064551003709 ATP binding site [chemical binding]; other site 1064551003710 Q-loop/lid; other site 1064551003711 ABC transporter signature motif; other site 1064551003712 Walker B; other site 1064551003713 D-loop; other site 1064551003714 H-loop/switch region; other site 1064551003715 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064551003716 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 1064551003717 Walker A/P-loop; other site 1064551003718 ATP binding site [chemical binding]; other site 1064551003719 Q-loop/lid; other site 1064551003720 ABC transporter signature motif; other site 1064551003721 Walker B; other site 1064551003722 D-loop; other site 1064551003723 H-loop/switch region; other site 1064551003724 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1064551003725 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1064551003726 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1064551003727 dimerization interface [polypeptide binding]; other site 1064551003728 zinc/cadmium-binding protein; Provisional; Region: PRK10306 1064551003729 aminoglycoside resistance protein; Provisional; Region: PRK13746 1064551003730 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1064551003731 active site 1064551003732 NTP binding site [chemical binding]; other site 1064551003733 metal binding triad [ion binding]; metal-binding site 1064551003734 antibiotic binding site [chemical binding]; other site 1064551003735 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 1064551003736 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064551003737 DNA binding residues [nucleotide binding] 1064551003738 transcriptional regulator MirA; Provisional; Region: PRK15043 1064551003739 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1064551003740 DNA binding residues [nucleotide binding] 1064551003741 dimer interface [polypeptide binding]; other site 1064551003742 Pleckstrin homology-like domain; Region: PH-like; cl17171 1064551003743 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 1064551003744 chorismate mutase; Provisional; Region: PRK08055 1064551003745 leucine export protein LeuE; Provisional; Region: PRK10958 1064551003746 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 1064551003747 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 1064551003748 hypothetical protein; Provisional; Region: PRK10457 1064551003749 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 1064551003750 murein hydrolase B; Provisional; Region: PRK10760; cl17906 1064551003751 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1064551003752 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1064551003753 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1064551003754 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551003755 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1064551003756 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064551003757 Predicted membrane protein [Function unknown]; Region: COG2707 1064551003758 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 1064551003759 putative deacylase active site [active] 1064551003760 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1064551003761 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064551003762 metal binding site [ion binding]; metal-binding site 1064551003763 active site 1064551003764 I-site; other site 1064551003765 hypothetical protein; Provisional; Region: PRK05325 1064551003766 PrkA family serine protein kinase; Provisional; Region: PRK15455 1064551003767 AAA ATPase domain; Region: AAA_16; pfam13191 1064551003768 Walker A motif; other site 1064551003769 ATP binding site [chemical binding]; other site 1064551003770 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1064551003771 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1064551003772 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1064551003773 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064551003774 FeS/SAM binding site; other site 1064551003775 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1064551003776 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1064551003777 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1064551003778 active site 1064551003779 catalytic tetrad [active] 1064551003780 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1064551003781 active site 1064551003782 phosphate binding residues; other site 1064551003783 catalytic residues [active] 1064551003784 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 1064551003785 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1064551003786 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1064551003787 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1064551003788 SelR domain; Region: SelR; pfam01641 1064551003789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 1064551003790 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1064551003791 Isochorismatase family; Region: Isochorismatase; pfam00857 1064551003792 catalytic triad [active] 1064551003793 metal binding site [ion binding]; metal-binding site 1064551003794 conserved cis-peptide bond; other site 1064551003795 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1064551003796 active site 1064551003797 homodimer interface [polypeptide binding]; other site 1064551003798 protease 4; Provisional; Region: PRK10949 1064551003799 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1064551003800 tandem repeat interface [polypeptide binding]; other site 1064551003801 oligomer interface [polypeptide binding]; other site 1064551003802 active site residues [active] 1064551003803 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 1064551003804 tandem repeat interface [polypeptide binding]; other site 1064551003805 oligomer interface [polypeptide binding]; other site 1064551003806 active site residues [active] 1064551003807 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1064551003808 putative FMN binding site [chemical binding]; other site 1064551003809 selenophosphate synthetase; Provisional; Region: PRK00943 1064551003810 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1064551003811 dimerization interface [polypeptide binding]; other site 1064551003812 putative ATP binding site [chemical binding]; other site 1064551003813 DNA topoisomerase III; Provisional; Region: PRK07726 1064551003814 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1064551003815 active site 1064551003816 putative interdomain interaction site [polypeptide binding]; other site 1064551003817 putative metal-binding site [ion binding]; other site 1064551003818 putative nucleotide binding site [chemical binding]; other site 1064551003819 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1064551003820 domain I; other site 1064551003821 DNA binding groove [nucleotide binding] 1064551003822 phosphate binding site [ion binding]; other site 1064551003823 domain II; other site 1064551003824 domain III; other site 1064551003825 nucleotide binding site [chemical binding]; other site 1064551003826 catalytic site [active] 1064551003827 domain IV; other site 1064551003828 glutamate dehydrogenase; Provisional; Region: PRK09414 1064551003829 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1064551003830 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1064551003831 NAD(P) binding site [chemical binding]; other site 1064551003832 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 1064551003833 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1064551003834 active site 1064551003835 8-oxo-dGMP binding site [chemical binding]; other site 1064551003836 nudix motif; other site 1064551003837 metal binding site [ion binding]; metal-binding site 1064551003838 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1064551003839 putative catalytic site [active] 1064551003840 putative phosphate binding site [ion binding]; other site 1064551003841 active site 1064551003842 metal binding site A [ion binding]; metal-binding site 1064551003843 DNA binding site [nucleotide binding] 1064551003844 putative AP binding site [nucleotide binding]; other site 1064551003845 putative metal binding site B [ion binding]; other site 1064551003846 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 1064551003847 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1064551003848 inhibitor-cofactor binding pocket; inhibition site 1064551003849 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551003850 catalytic residue [active] 1064551003851 arginine succinyltransferase; Provisional; Region: PRK10456 1064551003852 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1064551003853 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 1064551003854 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 1064551003855 NAD(P) binding site [chemical binding]; other site 1064551003856 catalytic residues [active] 1064551003857 succinylarginine dihydrolase; Provisional; Region: PRK13281 1064551003858 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 1064551003859 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1064551003860 putative active site [active] 1064551003861 Zn binding site [ion binding]; other site 1064551003862 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1064551003863 dimer interface [polypeptide binding]; other site 1064551003864 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 1064551003865 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1064551003866 GIY-YIG motif/motif A; other site 1064551003867 active site 1064551003868 catalytic site [active] 1064551003869 putative DNA binding site [nucleotide binding]; other site 1064551003870 metal binding site [ion binding]; metal-binding site 1064551003871 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1064551003872 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1064551003873 homodimer interface [polypeptide binding]; other site 1064551003874 NAD binding pocket [chemical binding]; other site 1064551003875 ATP binding pocket [chemical binding]; other site 1064551003876 Mg binding site [ion binding]; other site 1064551003877 active-site loop [active] 1064551003878 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 1064551003879 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1064551003880 active site 1064551003881 P-loop; other site 1064551003882 phosphorylation site [posttranslational modification] 1064551003883 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 1064551003884 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1064551003885 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1064551003886 methionine cluster; other site 1064551003887 active site 1064551003888 phosphorylation site [posttranslational modification] 1064551003889 metal binding site [ion binding]; metal-binding site 1064551003890 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 1064551003891 Cupin domain; Region: Cupin_2; pfam07883 1064551003892 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064551003893 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1064551003894 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1064551003895 NAD binding site [chemical binding]; other site 1064551003896 sugar binding site [chemical binding]; other site 1064551003897 divalent metal binding site [ion binding]; other site 1064551003898 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1064551003899 dimer interface [polypeptide binding]; other site 1064551003900 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 1064551003901 putative active site [active] 1064551003902 YdjC motif; other site 1064551003903 Mg binding site [ion binding]; other site 1064551003904 putative homodimer interface [polypeptide binding]; other site 1064551003905 hydroperoxidase II; Provisional; Region: katE; PRK11249 1064551003906 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1064551003907 tetramer interface [polypeptide binding]; other site 1064551003908 heme binding pocket [chemical binding]; other site 1064551003909 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1064551003910 domain interactions; other site 1064551003911 cell division modulator; Provisional; Region: PRK10113 1064551003912 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1064551003913 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1064551003914 inner membrane protein; Provisional; Region: PRK11648 1064551003915 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 1064551003916 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1064551003917 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064551003918 motif II; other site 1064551003919 YniB-like protein; Region: YniB; pfam14002 1064551003920 Phosphotransferase enzyme family; Region: APH; pfam01636 1064551003921 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1064551003922 active site 1064551003923 ATP binding site [chemical binding]; other site 1064551003924 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1064551003925 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 1064551003926 6-phosphofructokinase 2; Provisional; Region: PRK10294 1064551003927 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1064551003928 putative substrate binding site [chemical binding]; other site 1064551003929 putative ATP binding site [chemical binding]; other site 1064551003930 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 1064551003931 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528 1064551003932 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 1064551003933 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1064551003934 active site 1064551003935 substrate binding site [chemical binding]; other site 1064551003936 Mg2+ binding site [ion binding]; other site 1064551003937 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1064551003938 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1064551003939 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1064551003940 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1064551003941 active site 1064551003942 dimer interface [polypeptide binding]; other site 1064551003943 motif 1; other site 1064551003944 motif 2; other site 1064551003945 motif 3; other site 1064551003946 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1064551003947 anticodon binding site; other site 1064551003948 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1064551003949 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1064551003950 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1064551003951 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1064551003952 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1064551003953 23S rRNA binding site [nucleotide binding]; other site 1064551003954 L21 binding site [polypeptide binding]; other site 1064551003955 L13 binding site [polypeptide binding]; other site 1064551003956 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1064551003957 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1064551003958 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1064551003959 dimer interface [polypeptide binding]; other site 1064551003960 motif 1; other site 1064551003961 active site 1064551003962 motif 2; other site 1064551003963 motif 3; other site 1064551003964 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1064551003965 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1064551003966 putative tRNA-binding site [nucleotide binding]; other site 1064551003967 B3/4 domain; Region: B3_4; pfam03483 1064551003968 tRNA synthetase B5 domain; Region: B5; smart00874 1064551003969 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1064551003970 dimer interface [polypeptide binding]; other site 1064551003971 motif 1; other site 1064551003972 motif 3; other site 1064551003973 motif 2; other site 1064551003974 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1064551003975 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1064551003976 IHF dimer interface [polypeptide binding]; other site 1064551003977 IHF - DNA interface [nucleotide binding]; other site 1064551003978 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1064551003979 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1064551003980 ABC-ATPase subunit interface; other site 1064551003981 dimer interface [polypeptide binding]; other site 1064551003982 putative PBP binding regions; other site 1064551003983 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1064551003984 catalytic residues [active] 1064551003985 dimer interface [polypeptide binding]; other site 1064551003986 ABC-type cobalamin transport system, ATPase component [Coenzyme metabolism]; Region: BtuD; COG4138 1064551003987 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1064551003988 Walker A/P-loop; other site 1064551003989 ATP binding site [chemical binding]; other site 1064551003990 Q-loop/lid; other site 1064551003991 ABC transporter signature motif; other site 1064551003992 Walker B; other site 1064551003993 D-loop; other site 1064551003994 H-loop/switch region; other site 1064551003995 NlpC/P60 family; Region: NLPC_P60; pfam00877 1064551003996 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 1064551003997 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1064551003998 hypothetical protein; Validated; Region: PRK00029 1064551003999 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 1064551004000 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 1064551004001 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1064551004002 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1064551004003 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1064551004004 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1064551004005 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1064551004006 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1064551004007 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 1064551004008 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 1064551004009 acyl-activating enzyme (AAE) consensus motif; other site 1064551004010 putative AMP binding site [chemical binding]; other site 1064551004011 putative active site [active] 1064551004012 putative CoA binding site [chemical binding]; other site 1064551004013 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 1064551004014 oxidoreductase; Provisional; Region: PRK10015 1064551004015 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 1064551004016 Electron transfer flavoprotein domain; Region: ETF; smart00893 1064551004017 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1064551004018 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1064551004019 Ligand binding site [chemical binding]; other site 1064551004020 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1064551004021 Cupin domain; Region: Cupin_2; pfam07883 1064551004022 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1064551004023 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064551004024 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 1064551004025 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1064551004026 active site 1064551004027 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 1064551004028 Coenzyme A transferase; Region: CoA_trans; smart00882 1064551004029 Coenzyme A transferase; Region: CoA_trans; cl17247 1064551004030 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1064551004031 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1064551004032 active site 1064551004033 catalytic residue [active] 1064551004034 dimer interface [polypeptide binding]; other site 1064551004035 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 1064551004036 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1064551004037 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1064551004038 shikimate binding site; other site 1064551004039 NAD(P) binding site [chemical binding]; other site 1064551004040 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551004041 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1064551004042 putative substrate translocation pore; other site 1064551004043 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551004044 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1064551004045 putative substrate translocation pore; other site 1064551004046 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 1064551004047 putative inner membrane protein; Provisional; Region: PRK10983 1064551004048 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1064551004049 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1064551004050 FAD binding domain; Region: FAD_binding_4; pfam01565 1064551004051 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1064551004052 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1064551004053 CoenzymeA binding site [chemical binding]; other site 1064551004054 subunit interaction site [polypeptide binding]; other site 1064551004055 PHB binding site; other site 1064551004056 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1064551004057 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1064551004058 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 1064551004059 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1064551004060 putative ABC transporter; Region: ycf24; CHL00085 1064551004061 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 1064551004062 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1064551004063 Walker A/P-loop; other site 1064551004064 ATP binding site [chemical binding]; other site 1064551004065 Q-loop/lid; other site 1064551004066 ABC transporter signature motif; other site 1064551004067 Walker B; other site 1064551004068 D-loop; other site 1064551004069 H-loop/switch region; other site 1064551004070 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 1064551004071 FeS assembly protein SufD; Region: sufD; TIGR01981 1064551004072 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1064551004073 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1064551004074 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1064551004075 catalytic residue [active] 1064551004076 cysteine desufuration protein SufE; Provisional; Region: PRK09296 1064551004077 L,D-transpeptidase; Provisional; Region: PRK10190 1064551004078 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1064551004079 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1064551004080 murein lipoprotein; Provisional; Region: PRK15396 1064551004081 murein lipoprotein; Provisional; Region: PRK15396 1064551004082 pyruvate kinase; Provisional; Region: PRK09206 1064551004083 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1064551004084 domain interfaces; other site 1064551004085 active site 1064551004086 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1064551004087 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1064551004088 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1064551004089 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1064551004090 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1064551004091 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1064551004092 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1064551004093 substrate binding site [chemical binding]; other site 1064551004094 dimer interface [polypeptide binding]; other site 1064551004095 ATP binding site [chemical binding]; other site 1064551004096 tetrathionate reductase subunit A; Provisional; Region: PRK14991 1064551004097 The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758 1064551004098 putative [Fe4-S4] binding site [ion binding]; other site 1064551004099 putative molybdopterin cofactor binding site [chemical binding]; other site 1064551004100 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 1064551004101 putative molybdopterin cofactor binding site; other site 1064551004102 tetrathionate reductase subunit C; Provisional; Region: PRK14992 1064551004103 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1064551004104 tetrathionate reductase subunit B; Provisional; Region: PRK14993 1064551004105 4Fe-4S binding domain; Region: Fer4; pfam00037 1064551004106 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1064551004107 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1064551004108 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064551004109 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064551004110 dimer interface [polypeptide binding]; other site 1064551004111 phosphorylation site [posttranslational modification] 1064551004112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064551004113 ATP binding site [chemical binding]; other site 1064551004114 Mg2+ binding site [ion binding]; other site 1064551004115 G-X-G motif; other site 1064551004116 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1064551004117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064551004118 active site 1064551004119 phosphorylation site [posttranslational modification] 1064551004120 intermolecular recognition site; other site 1064551004121 dimerization interface [polypeptide binding]; other site 1064551004122 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064551004123 DNA binding residues [nucleotide binding] 1064551004124 dimerization interface [polypeptide binding]; other site 1064551004125 hypothetical protein; Provisional; Region: PRK10292 1064551004126 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1064551004127 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1064551004128 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 1064551004129 transcriptional regulator MirA; Provisional; Region: PRK15043 1064551004130 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1064551004131 DNA binding residues [nucleotide binding] 1064551004132 two component system sensor kinase SsrB; Provisional; Region: PRK15369 1064551004133 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064551004134 active site 1064551004135 phosphorylation site [posttranslational modification] 1064551004136 intermolecular recognition site; other site 1064551004137 dimerization interface [polypeptide binding]; other site 1064551004138 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064551004139 DNA binding residues [nucleotide binding] 1064551004140 dimerization interface [polypeptide binding]; other site 1064551004141 two component system sensor kinase SsrA; Provisional; Region: PRK15347 1064551004142 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064551004143 dimerization interface [polypeptide binding]; other site 1064551004144 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064551004145 dimer interface [polypeptide binding]; other site 1064551004146 phosphorylation site [posttranslational modification] 1064551004147 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064551004148 ATP binding site [chemical binding]; other site 1064551004149 Mg2+ binding site [ion binding]; other site 1064551004150 G-X-G motif; other site 1064551004151 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064551004152 active site 1064551004153 phosphorylation site [posttranslational modification] 1064551004154 intermolecular recognition site; other site 1064551004155 dimerization interface [polypeptide binding]; other site 1064551004156 pathogenicity island chaperone protein SpiC; Provisional; Region: PRK15368 1064551004157 outer membrane secretin SsaC; Provisional; Region: PRK15346 1064551004158 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1064551004159 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1064551004160 type III secretion system protein SsaD; Provisional; Region: PRK15367 1064551004161 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 1064551004162 type III secretion system chaperone SsaE; Provisional; Region: PRK15366 1064551004163 type III secretion system chaperone SseA; Provisional; Region: PRK15365 1064551004164 pathogenicity island 2 effector protein SseB; Provisional; Region: PRK15364 1064551004165 pathogenicity island 2 chaperone protein SscA; Provisional; Region: PRK15363 1064551004166 pathogenicity island 2 effector protein SseC; Provisional; Region: PRK15362 1064551004167 pathogenicity island 2 effector protein SseD; Provisional; Region: PRK15361 1064551004168 pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360 1064551004169 type III secretion system chaperone protein SscB; Provisional; Region: PRK15359 1064551004170 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064551004171 TPR motif; other site 1064551004172 binding surface 1064551004173 pathogenicity island 2 effector protein SseF; Provisional; Region: PRK15358 1064551004174 pathogenicity island 2 effector protein SseG; Provisional; Region: PRK15357 1064551004175 type III secretion system needle protein SsaG; Provisional; Region: PRK15344 1064551004176 type III secretion system protein SsaH; Provisional; Region: PRK15356 1064551004177 type III secretion system protein SsaI; Provisional; Region: PRK15355 1064551004178 type III secretion system lipoprotein SsaJ; Provisional; Region: PRK15348 1064551004179 Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327 1064551004180 type III secretion system protein SsaK; Provisional; Region: PRK15354 1064551004181 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 1064551004182 type III secretion system protein SsaL; Provisional; Region: PRK15345 1064551004183 HrpJ-like domain; Region: HrpJ; pfam07201 1064551004184 TyeA; Region: TyeA; cl07611 1064551004185 type III secretion system protein SsaM; Provisional; Region: PRK15353 1064551004186 secretion system apparatus protein SsaV; Provisional; Region: PRK12720 1064551004187 FHIPEP family; Region: FHIPEP; pfam00771 1064551004188 type III secretion system ATPase SsaN; Validated; Region: PRK07594 1064551004189 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1064551004190 Walker A motif; other site 1064551004191 ATP binding site [chemical binding]; other site 1064551004192 Walker B motif; other site 1064551004193 type III secretion system protein SsaO; Provisional; Region: PRK15352 1064551004194 type III secretion system protein SsaP; Provisional; Region: PRK15351 1064551004195 type III secretion system protein SsaQ; Validated; Region: PRK08035 1064551004196 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 1064551004197 Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790 1064551004198 type III secretion system protein SsaS; Provisional; Region: PRK15350 1064551004199 type III secretion system protein SsaT; Provisional; Region: PRK15349 1064551004200 secretion system apparatus protein SsaU; Reviewed; Region: PRK12721 1064551004201 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1064551004202 multidrug efflux protein; Reviewed; Region: PRK01766 1064551004203 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1064551004204 cation binding site [ion binding]; other site 1064551004205 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 1064551004206 Lumazine binding domain; Region: Lum_binding; pfam00677 1064551004207 Lumazine binding domain; Region: Lum_binding; pfam00677 1064551004208 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 1064551004209 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1064551004210 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064551004211 S-adenosylmethionine binding site [chemical binding]; other site 1064551004212 putative transporter; Provisional; Region: PRK11043 1064551004213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551004214 putative substrate translocation pore; other site 1064551004215 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1064551004216 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551004217 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1064551004218 dimerization interface [polypeptide binding]; other site 1064551004219 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 1064551004220 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1064551004221 DNA binding site [nucleotide binding] 1064551004222 domain linker motif; other site 1064551004223 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1064551004224 dimerization interface [polypeptide binding]; other site 1064551004225 ligand binding site [chemical binding]; other site 1064551004226 superoxide dismutase; Provisional; Region: PRK10543 1064551004227 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1064551004228 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1064551004229 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1064551004230 NlpC/P60 family; Region: NLPC_P60; pfam00877 1064551004231 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1064551004232 putative GSH binding site [chemical binding]; other site 1064551004233 catalytic residues [active] 1064551004234 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1064551004235 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 1064551004236 dimer interface [polypeptide binding]; other site 1064551004237 catalytic site [active] 1064551004238 putative active site [active] 1064551004239 putative substrate binding site [chemical binding]; other site 1064551004240 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1064551004241 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1064551004242 dimer interface [polypeptide binding]; other site 1064551004243 active site 1064551004244 metal binding site [ion binding]; metal-binding site 1064551004245 glutathione binding site [chemical binding]; other site 1064551004246 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1064551004247 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1064551004248 FMN binding site [chemical binding]; other site 1064551004249 active site 1064551004250 substrate binding site [chemical binding]; other site 1064551004251 catalytic residue [active] 1064551004252 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1064551004253 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1064551004254 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1064551004255 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1064551004256 active site 1064551004257 catalytic tetrad [active] 1064551004258 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1064551004259 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1064551004260 E-class dimer interface [polypeptide binding]; other site 1064551004261 P-class dimer interface [polypeptide binding]; other site 1064551004262 active site 1064551004263 Cu2+ binding site [ion binding]; other site 1064551004264 Zn2+ binding site [ion binding]; other site 1064551004265 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1064551004266 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1064551004267 HlyD family secretion protein; Region: HlyD; pfam00529 1064551004268 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1064551004269 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064551004270 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 1064551004271 transcriptional regulator SlyA; Provisional; Region: PRK03573 1064551004272 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1064551004273 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 1064551004274 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1064551004275 lysozyme inhibitor; Provisional; Region: PRK11372 1064551004276 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1064551004277 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1064551004278 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1064551004279 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1064551004280 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1064551004281 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1064551004282 active site 1064551004283 HIGH motif; other site 1064551004284 dimer interface [polypeptide binding]; other site 1064551004285 KMSKS motif; other site 1064551004286 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1064551004287 RNA binding surface [nucleotide binding]; other site 1064551004288 pyridoxamine kinase; Validated; Region: PRK05756 1064551004289 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1064551004290 dimer interface [polypeptide binding]; other site 1064551004291 pyridoxal binding site [chemical binding]; other site 1064551004292 ATP binding site [chemical binding]; other site 1064551004293 glutathionine S-transferase; Provisional; Region: PRK10542 1064551004294 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1064551004295 C-terminal domain interface [polypeptide binding]; other site 1064551004296 GSH binding site (G-site) [chemical binding]; other site 1064551004297 dimer interface [polypeptide binding]; other site 1064551004298 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1064551004299 dimer interface [polypeptide binding]; other site 1064551004300 N-terminal domain interface [polypeptide binding]; other site 1064551004301 substrate binding pocket (H-site) [chemical binding]; other site 1064551004302 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1064551004303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551004304 putative substrate translocation pore; other site 1064551004305 POT family; Region: PTR2; pfam00854 1064551004306 endonuclease III; Provisional; Region: PRK10702 1064551004307 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1064551004308 minor groove reading motif; other site 1064551004309 helix-hairpin-helix signature motif; other site 1064551004310 substrate binding pocket [chemical binding]; other site 1064551004311 active site 1064551004312 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1064551004313 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1064551004314 electron transport complex protein RnfG; Validated; Region: PRK01908 1064551004315 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 1064551004316 electron transport complex protein RnfB; Provisional; Region: PRK05113 1064551004317 Putative Fe-S cluster; Region: FeS; cl17515 1064551004318 4Fe-4S binding domain; Region: Fer4; pfam00037 1064551004319 electron transport complex protein RsxA; Provisional; Region: PRK05151 1064551004320 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 1064551004321 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 1064551004322 putative oxidoreductase; Provisional; Region: PRK11579 1064551004323 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1064551004324 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1064551004325 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1064551004326 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1064551004327 active site 1064551004328 purine riboside binding site [chemical binding]; other site 1064551004329 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1064551004330 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1064551004331 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551004332 homodimer interface [polypeptide binding]; other site 1064551004333 catalytic residue [active] 1064551004334 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 1064551004335 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1064551004336 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1064551004337 active site turn [active] 1064551004338 phosphorylation site [posttranslational modification] 1064551004339 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 1064551004340 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1064551004341 DNA binding site [nucleotide binding] 1064551004342 domain linker motif; other site 1064551004343 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 1064551004344 putative dimerization interface [polypeptide binding]; other site 1064551004345 putative ligand binding site [chemical binding]; other site 1064551004346 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 1064551004347 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 1064551004348 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1064551004349 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1064551004350 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1064551004351 fumarate hydratase; Provisional; Region: PRK15389 1064551004352 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 1064551004353 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1064551004354 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1064551004355 Class II fumarases; Region: Fumarase_classII; cd01362 1064551004356 active site 1064551004357 tetramer interface [polypeptide binding]; other site 1064551004358 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 1064551004359 sensor protein RstB; Provisional; Region: PRK10604 1064551004360 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064551004361 dimerization interface [polypeptide binding]; other site 1064551004362 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064551004363 dimer interface [polypeptide binding]; other site 1064551004364 phosphorylation site [posttranslational modification] 1064551004365 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064551004366 ATP binding site [chemical binding]; other site 1064551004367 Mg2+ binding site [ion binding]; other site 1064551004368 G-X-G motif; other site 1064551004369 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1064551004370 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1064551004371 active site 1064551004372 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1064551004373 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1064551004374 trimer interface [polypeptide binding]; other site 1064551004375 eyelet of channel; other site 1064551004376 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 1064551004377 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064551004378 active site 1064551004379 phosphorylation site [posttranslational modification] 1064551004380 intermolecular recognition site; other site 1064551004381 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1064551004382 DNA binding site [nucleotide binding] 1064551004383 GlpM protein; Region: GlpM; pfam06942 1064551004384 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1064551004385 Spore germination protein; Region: Spore_permease; cl17796 1064551004386 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1064551004387 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1064551004388 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1064551004389 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 1064551004390 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1064551004391 ligand binding site [chemical binding]; other site 1064551004392 homodimer interface [polypeptide binding]; other site 1064551004393 NAD(P) binding site [chemical binding]; other site 1064551004394 trimer interface B [polypeptide binding]; other site 1064551004395 trimer interface A [polypeptide binding]; other site 1064551004396 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1064551004397 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 1064551004398 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1064551004399 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 1064551004400 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1064551004401 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 1064551004402 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 1064551004403 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1064551004404 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1064551004405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551004406 putative substrate translocation pore; other site 1064551004407 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1064551004408 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551004409 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1064551004410 dimerization interface [polypeptide binding]; other site 1064551004411 substrate binding pocket [chemical binding]; other site 1064551004412 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1064551004413 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1064551004414 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1064551004415 nucleotide binding site [chemical binding]; other site 1064551004416 putative dithiobiotin synthetase; Provisional; Region: PRK12374 1064551004417 AAA domain; Region: AAA_26; pfam13500 1064551004418 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1064551004419 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1064551004420 Cl- selectivity filter; other site 1064551004421 Cl- binding residues [ion binding]; other site 1064551004422 pore gating glutamate residue; other site 1064551004423 dimer interface [polypeptide binding]; other site 1064551004424 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1064551004425 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1064551004426 Walker A/P-loop; other site 1064551004427 ATP binding site [chemical binding]; other site 1064551004428 Q-loop/lid; other site 1064551004429 ABC transporter signature motif; other site 1064551004430 Walker B; other site 1064551004431 D-loop; other site 1064551004432 H-loop/switch region; other site 1064551004433 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 1064551004434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551004435 dimer interface [polypeptide binding]; other site 1064551004436 conserved gate region; other site 1064551004437 ABC-ATPase subunit interface; other site 1064551004438 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1064551004439 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551004440 dimer interface [polypeptide binding]; other site 1064551004441 conserved gate region; other site 1064551004442 putative PBP binding loops; other site 1064551004443 ABC-ATPase subunit interface; other site 1064551004444 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 1064551004445 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 1064551004446 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1064551004447 4Fe-4S binding domain; Region: Fer4; pfam00037 1064551004448 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1064551004449 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1064551004450 putative [Fe4-S4] binding site [ion binding]; other site 1064551004451 putative molybdopterin cofactor binding site [chemical binding]; other site 1064551004452 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1064551004453 putative molybdopterin cofactor binding site; other site 1064551004454 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1064551004455 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1064551004456 putative [Fe4-S4] binding site [ion binding]; other site 1064551004457 putative molybdopterin cofactor binding site [chemical binding]; other site 1064551004458 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1064551004459 putative molybdopterin cofactor binding site; other site 1064551004460 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 1064551004461 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 1064551004462 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 1064551004463 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064551004464 Coenzyme A binding pocket [chemical binding]; other site 1064551004465 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1064551004466 hypothetical protein; Provisional; Region: PRK13659 1064551004467 hypothetical protein; Provisional; Region: PRK02237 1064551004468 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 1064551004469 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 1064551004470 putative active site pocket [active] 1064551004471 putative metal binding site [ion binding]; other site 1064551004472 putative oxidoreductase; Provisional; Region: PRK10083 1064551004473 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1064551004474 putative NAD(P) binding site [chemical binding]; other site 1064551004475 catalytic Zn binding site [ion binding]; other site 1064551004476 structural Zn binding site [ion binding]; other site 1064551004477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551004478 metabolite-proton symporter; Region: 2A0106; TIGR00883 1064551004479 putative substrate translocation pore; other site 1064551004480 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1064551004481 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1064551004482 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1064551004483 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 1064551004484 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1064551004485 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064551004486 DNA-binding site [nucleotide binding]; DNA binding site 1064551004487 FCD domain; Region: FCD; pfam07729 1064551004488 malonic semialdehyde reductase; Provisional; Region: PRK10538 1064551004489 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1064551004490 putative NAD(P) binding site [chemical binding]; other site 1064551004491 homodimer interface [polypeptide binding]; other site 1064551004492 homotetramer interface [polypeptide binding]; other site 1064551004493 active site 1064551004494 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 1064551004495 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1064551004496 active site 1064551004497 Zn binding site [ion binding]; other site 1064551004498 General stress protein [General function prediction only]; Region: GsiB; COG3729 1064551004499 hypothetical protein; Validated; Region: PRK03657 1064551004500 hypothetical protein; Provisional; Region: PRK10053 1064551004501 putative transporter; Provisional; Region: PRK10054 1064551004502 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551004503 putative substrate translocation pore; other site 1064551004504 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1064551004505 EamA-like transporter family; Region: EamA; pfam00892 1064551004506 MarB protein; Region: MarB; pfam13999 1064551004507 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 1064551004508 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064551004509 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064551004510 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 1064551004511 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1064551004512 inner membrane protein; Provisional; Region: PRK10995 1064551004513 putative arabinose transporter; Provisional; Region: PRK03545 1064551004514 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551004515 putative substrate translocation pore; other site 1064551004516 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064551004517 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551004518 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1064551004519 putative dimerization interface [polypeptide binding]; other site 1064551004520 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 1064551004521 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1064551004522 NAD(P) binding site [chemical binding]; other site 1064551004523 catalytic residues [active] 1064551004524 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1064551004525 glutaminase; Provisional; Region: PRK00971 1064551004526 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 1064551004527 Predicted membrane protein [Function unknown]; Region: COG3781 1064551004528 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1064551004529 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1064551004530 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1064551004531 trimer interface [polypeptide binding]; other site 1064551004532 eyelet of channel; other site 1064551004533 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 1064551004534 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 1064551004535 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 1064551004536 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 1064551004537 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 1064551004538 Rubredoxin [Energy production and conversion]; Region: COG1773 1064551004539 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1064551004540 iron binding site [ion binding]; other site 1064551004541 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 1064551004542 HupF/HypC family; Region: HupF_HypC; cl00394 1064551004543 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 1064551004544 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1064551004545 putative substrate-binding site; other site 1064551004546 nickel binding site [ion binding]; other site 1064551004547 Ni,Fe-hydrogenase I cytochrome b subunit [Energy production and conversion]; Region: HyaC; COG1969 1064551004548 hydrogenase 1 large subunit; Provisional; Region: PRK10170 1064551004549 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1064551004550 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 1064551004551 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1064551004552 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1064551004553 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1064551004554 active site 1064551004555 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1064551004556 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064551004557 DNA-binding site [nucleotide binding]; DNA binding site 1064551004558 FCD domain; Region: FCD; pfam07729 1064551004559 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1064551004560 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1064551004561 putative NAD(P) binding site [chemical binding]; other site 1064551004562 catalytic Zn binding site [ion binding]; other site 1064551004563 structural Zn binding site [ion binding]; other site 1064551004564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551004565 D-galactonate transporter; Region: 2A0114; TIGR00893 1064551004566 putative substrate translocation pore; other site 1064551004567 PhoPQ-activated pathogenicity-related protein [General function prediction only]; Region: PqaA; COG4287 1064551004568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551004569 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1064551004570 putative substrate translocation pore; other site 1064551004571 hypothetical protein; Provisional; Region: PRK06184 1064551004572 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1064551004573 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1064551004574 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1064551004575 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1064551004576 putative DNA binding site [nucleotide binding]; other site 1064551004577 putative Zn2+ binding site [ion binding]; other site 1064551004578 S-adenosylmethionine:tRNA-ribosyltransferase- isomerase (queuine synthetase) [Translation, ribosomal structure and biogenesis]; Region: QueA; COG0809 1064551004579 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1064551004580 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 1064551004581 homotrimer interaction site [polypeptide binding]; other site 1064551004582 putative active site [active] 1064551004583 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1064551004584 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1064551004585 Winged helix-turn helix; Region: HTH_29; pfam13551 1064551004586 Helix-turn-helix domain; Region: HTH_28; pfam13518 1064551004587 Homeodomain-like domain; Region: HTH_32; pfam13565 1064551004588 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1064551004589 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1064551004590 DNA binding site [nucleotide binding] 1064551004591 domain linker motif; other site 1064551004592 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1064551004593 dimerization interface (closed form) [polypeptide binding]; other site 1064551004594 ligand binding site [chemical binding]; other site 1064551004595 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1064551004596 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1064551004597 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1064551004598 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551004599 homodimer interface [polypeptide binding]; other site 1064551004600 catalytic residue [active] 1064551004601 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1064551004602 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1064551004603 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1064551004604 active site 1064551004605 catalytic site [active] 1064551004606 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 1064551004607 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1064551004608 active site 1064551004609 catalytic site [active] 1064551004610 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1064551004611 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1064551004612 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1064551004613 catalytic site [active] 1064551004614 active site 1064551004615 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1064551004616 Protein of unknown function (DUF1264); Region: DUF1264; pfam06884 1064551004617 acid-resistance protein; Provisional; Region: hdeB; PRK11566 1064551004618 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 1064551004619 biofilm-dependent modulation protein; Provisional; Region: PRK11436 1064551004620 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 1064551004621 malate dehydrogenase; Provisional; Region: PRK13529 1064551004622 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1064551004623 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1064551004624 NAD(P) binding site [chemical binding]; other site 1064551004625 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1064551004626 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1064551004627 NAD binding site [chemical binding]; other site 1064551004628 substrate binding site [chemical binding]; other site 1064551004629 catalytic Zn binding site [ion binding]; other site 1064551004630 tetramer interface [polypeptide binding]; other site 1064551004631 structural Zn binding site [ion binding]; other site 1064551004632 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 1064551004633 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1064551004634 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1064551004635 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1064551004636 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1064551004637 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1064551004638 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1064551004639 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1064551004640 molybdopterin cofactor binding site; other site 1064551004641 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1064551004642 aromatic amino acid exporter; Provisional; Region: PRK11689 1064551004643 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1064551004644 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1064551004645 trimer interface [polypeptide binding]; other site 1064551004646 eyelet of channel; other site 1064551004647 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 1064551004648 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1064551004649 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551004650 putative substrate translocation pore; other site 1064551004651 TetR family transcriptional regulator; Provisional; Region: PRK14996 1064551004652 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1064551004653 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1064551004654 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1064551004655 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1064551004656 [4Fe-4S] binding site [ion binding]; other site 1064551004657 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1064551004658 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1064551004659 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1064551004660 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1064551004661 molybdopterin cofactor binding site; other site 1064551004662 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1064551004663 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 1064551004664 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1064551004665 hypothetical protein; Provisional; Region: PRK10281 1064551004666 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 1064551004667 L-asparagine permease; Provisional; Region: PRK15049 1064551004668 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1064551004669 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1064551004670 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1064551004671 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1064551004672 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1064551004673 N-terminal plug; other site 1064551004674 ligand-binding site [chemical binding]; other site 1064551004675 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 1064551004676 DNA-binding site [nucleotide binding]; DNA binding site 1064551004677 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1064551004678 FCD domain; Region: FCD; pfam07729 1064551004679 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1064551004680 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1064551004681 NAD(P) binding site [chemical binding]; other site 1064551004682 substrate binding site [chemical binding]; other site 1064551004683 dimer interface [polypeptide binding]; other site 1064551004684 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1064551004685 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1064551004686 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1064551004687 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 1064551004688 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfB; COG4457 1064551004689 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458 1064551004690 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 1064551004691 1-pyrroline dehydrogenase; Region: ABALDH; TIGR03374 1064551004692 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1064551004693 tetrameric interface [polypeptide binding]; other site 1064551004694 NAD binding site [chemical binding]; other site 1064551004695 catalytic residues [active] 1064551004696 substrate binding site [chemical binding]; other site 1064551004697 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1064551004698 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064551004699 DNA-binding site [nucleotide binding]; DNA binding site 1064551004700 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1064551004701 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551004702 homodimer interface [polypeptide binding]; other site 1064551004703 catalytic residue [active] 1064551004704 D-alanyl-D-alanine dipeptidase [Cell envelope biogenesis, outer membrane]; Region: DdpX; COG2173 1064551004705 secreted effector protein SifB; Provisional; Region: sifB; PRK09499 1064551004706 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 1064551004707 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1064551004708 Peptidase family U32; Region: Peptidase_U32; pfam01136 1064551004709 Collagenase; Region: DUF3656; pfam12392 1064551004710 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1064551004711 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064551004712 non-specific DNA binding site [nucleotide binding]; other site 1064551004713 salt bridge; other site 1064551004714 sequence-specific DNA binding site [nucleotide binding]; other site 1064551004715 Cupin domain; Region: Cupin_2; pfam07883 1064551004716 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 1064551004717 benzoate transporter; Region: benE; TIGR00843 1064551004718 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1064551004719 tellurite resistance protein TehB; Provisional; Region: PRK11207 1064551004720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064551004721 S-adenosylmethionine binding site [chemical binding]; other site 1064551004722 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1064551004723 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 1064551004724 gating phenylalanine in ion channel; other site 1064551004725 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1064551004726 putative trimer interface [polypeptide binding]; other site 1064551004727 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1064551004728 putative trimer interface [polypeptide binding]; other site 1064551004729 putative CoA binding site [chemical binding]; other site 1064551004730 putative CoA binding site [chemical binding]; other site 1064551004731 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 1064551004732 putative trimer interface [polypeptide binding]; other site 1064551004733 putative CoA binding site [chemical binding]; other site 1064551004734 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1064551004735 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064551004736 Coenzyme A binding pocket [chemical binding]; other site 1064551004737 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1064551004738 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1064551004739 oligomer interface [polypeptide binding]; other site 1064551004740 active site 1064551004741 metal binding site [ion binding]; metal-binding site 1064551004742 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1064551004743 active site 1064551004744 P-loop; other site 1064551004745 phosphorylation site [posttranslational modification] 1064551004746 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1064551004747 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 1064551004748 membrane complex biogenesis protein, BtpA family; Region: thylakoid_BtpA; TIGR00259 1064551004749 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1064551004750 active site 1064551004751 phosphorylation site [posttranslational modification] 1064551004752 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1064551004753 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1064551004754 substrate binding site [chemical binding]; other site 1064551004755 hexamer interface [polypeptide binding]; other site 1064551004756 metal binding site [ion binding]; metal-binding site 1064551004757 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1064551004758 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1064551004759 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1064551004760 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064551004761 Coenzyme A binding pocket [chemical binding]; other site 1064551004762 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 1064551004763 teramer interface [polypeptide binding]; other site 1064551004764 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1064551004765 active site 1064551004766 FMN binding site [chemical binding]; other site 1064551004767 catalytic residues [active] 1064551004768 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1064551004769 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 1064551004770 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 1064551004771 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1064551004772 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1064551004773 substrate binding pocket [chemical binding]; other site 1064551004774 catalytic triad [active] 1064551004775 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1064551004776 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1064551004777 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1064551004778 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551004779 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1064551004780 dimerization interface [polypeptide binding]; other site 1064551004781 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1064551004782 dimer interface [polypeptide binding]; other site 1064551004783 ligand binding site [chemical binding]; other site 1064551004784 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1064551004785 HAMP domain; Region: HAMP; pfam00672 1064551004786 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064551004787 dimer interface [polypeptide binding]; other site 1064551004788 putative CheW interface [polypeptide binding]; other site 1064551004789 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1064551004790 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1064551004791 substrate binding site [chemical binding]; other site 1064551004792 catalytic Zn binding site [ion binding]; other site 1064551004793 NAD binding site [chemical binding]; other site 1064551004794 structural Zn binding site [ion binding]; other site 1064551004795 dimer interface [polypeptide binding]; other site 1064551004796 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1064551004797 putative metal binding site [ion binding]; other site 1064551004798 putative homodimer interface [polypeptide binding]; other site 1064551004799 putative homotetramer interface [polypeptide binding]; other site 1064551004800 putative homodimer-homodimer interface [polypeptide binding]; other site 1064551004801 putative allosteric switch controlling residues; other site 1064551004802 Sif protein; Region: Sif; cl11505 1064551004803 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 1064551004804 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 1064551004805 active site 1064551004806 catalytic triad [active] 1064551004807 oxyanion hole [active] 1064551004808 Predicted membrane protein [Function unknown]; Region: COG3326 1064551004809 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064551004810 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1064551004811 substrate binding pocket [chemical binding]; other site 1064551004812 membrane-bound complex binding site; other site 1064551004813 hinge residues; other site 1064551004814 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1064551004815 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551004816 dimer interface [polypeptide binding]; other site 1064551004817 conserved gate region; other site 1064551004818 putative PBP binding loops; other site 1064551004819 ABC-ATPase subunit interface; other site 1064551004820 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1064551004821 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064551004822 Walker A/P-loop; other site 1064551004823 ATP binding site [chemical binding]; other site 1064551004824 Q-loop/lid; other site 1064551004825 ABC transporter signature motif; other site 1064551004826 Walker B; other site 1064551004827 D-loop; other site 1064551004828 H-loop/switch region; other site 1064551004829 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1064551004830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551004831 dimer interface [polypeptide binding]; other site 1064551004832 conserved gate region; other site 1064551004833 putative PBP binding loops; other site 1064551004834 ABC-ATPase subunit interface; other site 1064551004835 Predicted membrane protein [Function unknown]; Region: COG5305 1064551004836 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064551004837 S-adenosylmethionine binding site [chemical binding]; other site 1064551004838 cytochrome b561; Provisional; Region: PRK11513 1064551004839 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1064551004840 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1064551004841 putative active site [active] 1064551004842 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1064551004843 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1064551004844 ATP binding site [chemical binding]; other site 1064551004845 putative Mg++ binding site [ion binding]; other site 1064551004846 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1064551004847 nucleotide binding region [chemical binding]; other site 1064551004848 ATP-binding site [chemical binding]; other site 1064551004849 Helicase associated domain (HA2); Region: HA2; pfam04408 1064551004850 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1064551004851 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1064551004852 azoreductase; Reviewed; Region: PRK00170 1064551004853 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1064551004854 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 1064551004855 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 1064551004856 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 1064551004857 hypothetical protein; Provisional; Region: PRK10695 1064551004858 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 1064551004859 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1064551004860 putative ligand binding site [chemical binding]; other site 1064551004861 putative NAD binding site [chemical binding]; other site 1064551004862 catalytic site [active] 1064551004863 heat-inducible protein; Provisional; Region: PRK10449 1064551004864 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 1064551004865 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1064551004866 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1064551004867 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1064551004868 dimer interface [polypeptide binding]; other site 1064551004869 PYR/PP interface [polypeptide binding]; other site 1064551004870 TPP binding site [chemical binding]; other site 1064551004871 substrate binding site [chemical binding]; other site 1064551004872 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1064551004873 Domain of unknown function; Region: EKR; smart00890 1064551004874 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1064551004875 4Fe-4S binding domain; Region: Fer4; pfam00037 1064551004876 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1064551004877 TPP-binding site [chemical binding]; other site 1064551004878 dimer interface [polypeptide binding]; other site 1064551004879 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1064551004880 Ligand Binding Site [chemical binding]; other site 1064551004881 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1064551004882 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1064551004883 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1064551004884 Ligand Binding Site [chemical binding]; other site 1064551004885 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1064551004886 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1064551004887 ATP binding site [chemical binding]; other site 1064551004888 Mg++ binding site [ion binding]; other site 1064551004889 motif III; other site 1064551004890 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1064551004891 nucleotide binding region [chemical binding]; other site 1064551004892 ATP-binding site [chemical binding]; other site 1064551004893 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 1064551004894 putative RNA binding site [nucleotide binding]; other site 1064551004895 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1064551004896 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 1064551004897 Cl binding site [ion binding]; other site 1064551004898 oligomer interface [polypeptide binding]; other site 1064551004899 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1064551004900 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064551004901 dimer interface [polypeptide binding]; other site 1064551004902 putative CheW interface [polypeptide binding]; other site 1064551004903 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1064551004904 Smr domain; Region: Smr; pfam01713 1064551004905 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 1064551004906 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1064551004907 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1064551004908 DNA binding site [nucleotide binding] 1064551004909 active site 1064551004910 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1064551004911 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1064551004912 ligand binding site [chemical binding]; other site 1064551004913 flexible hinge region; other site 1064551004914 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1064551004915 putative switch regulator; other site 1064551004916 non-specific DNA interactions [nucleotide binding]; other site 1064551004917 DNA binding site [nucleotide binding] 1064551004918 sequence specific DNA binding site [nucleotide binding]; other site 1064551004919 putative cAMP binding site [chemical binding]; other site 1064551004920 universal stress protein UspE; Provisional; Region: PRK11175 1064551004921 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1064551004922 Ligand Binding Site [chemical binding]; other site 1064551004923 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1064551004924 Ligand Binding Site [chemical binding]; other site 1064551004925 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 1064551004926 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1064551004927 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1064551004928 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1064551004929 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064551004930 non-specific DNA binding site [nucleotide binding]; other site 1064551004931 salt bridge; other site 1064551004932 sequence-specific DNA binding site [nucleotide binding]; other site 1064551004933 Cupin domain; Region: Cupin_2; pfam07883 1064551004934 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1064551004935 B3/4 domain; Region: B3_4; pfam03483 1064551004936 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1064551004937 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1064551004938 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 1064551004939 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064551004940 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1064551004941 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1064551004942 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1064551004943 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1064551004944 oxidoreductase; Provisional; Region: PRK12742 1064551004945 classical (c) SDRs; Region: SDR_c; cd05233 1064551004946 NAD(P) binding site [chemical binding]; other site 1064551004947 active site 1064551004948 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1064551004949 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1064551004950 active site 1064551004951 catalytic tetrad [active] 1064551004952 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064551004953 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551004954 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1064551004955 putative effector binding pocket; other site 1064551004956 putative dimerization interface [polypeptide binding]; other site 1064551004957 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 1064551004958 NmrA-like family; Region: NmrA; pfam05368 1064551004959 NAD(P) binding site [chemical binding]; other site 1064551004960 active site lysine 1064551004961 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1064551004962 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1064551004963 peptide binding site [polypeptide binding]; other site 1064551004964 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1064551004965 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 1064551004966 putative active site [active] 1064551004967 Zn binding site [ion binding]; other site 1064551004968 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 1064551004969 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1064551004970 active site 1064551004971 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1064551004972 dimer interface [polypeptide binding]; other site 1064551004973 catalytic triad [active] 1064551004974 peroxidatic and resolving cysteines [active] 1064551004975 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 1064551004976 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 1064551004977 putative aromatic amino acid binding site; other site 1064551004978 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064551004979 Walker A motif; other site 1064551004980 ATP binding site [chemical binding]; other site 1064551004981 Walker B motif; other site 1064551004982 arginine finger; other site 1064551004983 hypothetical protein; Provisional; Region: PRK05415 1064551004984 TIGR01620 family protein; Region: hyp_HI0043 1064551004985 Predicted ATPase [General function prediction only]; Region: COG3106 1064551004986 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1064551004987 active site residue [active] 1064551004988 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 1064551004989 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 1064551004990 phage shock protein C; Region: phageshock_pspC; TIGR02978 1064551004991 phage shock protein B; Provisional; Region: pspB; PRK09458 1064551004992 phage shock protein PspA; Provisional; Region: PRK10698 1064551004993 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 1064551004994 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064551004995 Walker A motif; other site 1064551004996 ATP binding site [chemical binding]; other site 1064551004997 Walker B motif; other site 1064551004998 arginine finger; other site 1064551004999 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1064551005000 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1064551005001 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1064551005002 peptide binding site [polypeptide binding]; other site 1064551005003 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 1064551005004 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551005005 dimer interface [polypeptide binding]; other site 1064551005006 conserved gate region; other site 1064551005007 putative PBP binding loops; other site 1064551005008 ABC-ATPase subunit interface; other site 1064551005009 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 1064551005010 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1064551005011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551005012 dimer interface [polypeptide binding]; other site 1064551005013 conserved gate region; other site 1064551005014 putative PBP binding loops; other site 1064551005015 ABC-ATPase subunit interface; other site 1064551005016 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 1064551005017 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1064551005018 Walker A/P-loop; other site 1064551005019 ATP binding site [chemical binding]; other site 1064551005020 Q-loop/lid; other site 1064551005021 ABC transporter signature motif; other site 1064551005022 Walker B; other site 1064551005023 D-loop; other site 1064551005024 H-loop/switch region; other site 1064551005025 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1064551005026 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 1064551005027 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1064551005028 Walker A/P-loop; other site 1064551005029 ATP binding site [chemical binding]; other site 1064551005030 Q-loop/lid; other site 1064551005031 ABC transporter signature motif; other site 1064551005032 Walker B; other site 1064551005033 D-loop; other site 1064551005034 H-loop/switch region; other site 1064551005035 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1064551005036 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 1064551005037 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1064551005038 NAD binding site [chemical binding]; other site 1064551005039 homotetramer interface [polypeptide binding]; other site 1064551005040 homodimer interface [polypeptide binding]; other site 1064551005041 substrate binding site [chemical binding]; other site 1064551005042 active site 1064551005043 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 1064551005044 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1064551005045 exoribonuclease II; Provisional; Region: PRK05054 1064551005046 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1064551005047 RNB domain; Region: RNB; pfam00773 1064551005048 S1 RNA binding domain; Region: S1; pfam00575 1064551005049 RNase II stability modulator; Provisional; Region: PRK10060 1064551005050 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064551005051 putative active site [active] 1064551005052 heme pocket [chemical binding]; other site 1064551005053 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064551005054 metal binding site [ion binding]; metal-binding site 1064551005055 active site 1064551005056 I-site; other site 1064551005057 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1064551005058 hypothetical protein; Provisional; Region: PRK13658 1064551005059 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1064551005060 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1064551005061 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1064551005062 lipoprotein; Provisional; Region: PRK10540 1064551005063 translation initiation factor Sui1; Validated; Region: PRK06824 1064551005064 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1064551005065 putative rRNA binding site [nucleotide binding]; other site 1064551005066 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1064551005067 active site 1064551005068 dimer interface [polypeptide binding]; other site 1064551005069 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 1064551005070 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064551005071 binding surface 1064551005072 TPR motif; other site 1064551005073 Predicted membrane protein [Function unknown]; Region: COG3771 1064551005074 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1064551005075 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1064551005076 active site 1064551005077 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1064551005078 dimerization interface [polypeptide binding]; other site 1064551005079 active site 1064551005080 aconitate hydratase; Validated; Region: PRK09277 1064551005081 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1064551005082 substrate binding site [chemical binding]; other site 1064551005083 ligand binding site [chemical binding]; other site 1064551005084 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1064551005085 substrate binding site [chemical binding]; other site 1064551005086 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 1064551005087 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551005088 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 1064551005089 substrate binding site [chemical binding]; other site 1064551005090 putative dimerization interface [polypeptide binding]; other site 1064551005091 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1064551005092 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1064551005093 active site 1064551005094 interdomain interaction site; other site 1064551005095 putative metal-binding site [ion binding]; other site 1064551005096 nucleotide binding site [chemical binding]; other site 1064551005097 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1064551005098 domain I; other site 1064551005099 DNA binding groove [nucleotide binding] 1064551005100 phosphate binding site [ion binding]; other site 1064551005101 domain II; other site 1064551005102 domain III; other site 1064551005103 nucleotide binding site [chemical binding]; other site 1064551005104 catalytic site [active] 1064551005105 domain IV; other site 1064551005106 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1064551005107 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1064551005108 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1064551005109 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1064551005110 hypothetical protein; Provisional; Region: PRK11037 1064551005111 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 1064551005112 putative inner membrane peptidase; Provisional; Region: PRK11778 1064551005113 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1064551005114 tandem repeat interface [polypeptide binding]; other site 1064551005115 oligomer interface [polypeptide binding]; other site 1064551005116 active site residues [active] 1064551005117 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 1064551005118 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 1064551005119 NADP binding site [chemical binding]; other site 1064551005120 homodimer interface [polypeptide binding]; other site 1064551005121 active site 1064551005122 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1064551005123 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 1064551005124 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1064551005125 homodimer interface [polypeptide binding]; other site 1064551005126 Walker A motif; other site 1064551005127 ATP binding site [chemical binding]; other site 1064551005128 hydroxycobalamin binding site [chemical binding]; other site 1064551005129 Walker B motif; other site 1064551005130 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 1064551005131 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1064551005132 RNA binding surface [nucleotide binding]; other site 1064551005133 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1064551005134 probable active site [active] 1064551005135 hypothetical protein; Provisional; Region: PRK11630 1064551005136 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1064551005137 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1064551005138 active site 1064551005139 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1064551005140 anthranilate synthase component I; Provisional; Region: PRK13564 1064551005141 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1064551005142 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1064551005143 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 1064551005144 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1064551005145 glutamine binding [chemical binding]; other site 1064551005146 catalytic triad [active] 1064551005147 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1064551005148 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1064551005149 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 1064551005150 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1064551005151 active site 1064551005152 ribulose/triose binding site [chemical binding]; other site 1064551005153 phosphate binding site [ion binding]; other site 1064551005154 substrate (anthranilate) binding pocket [chemical binding]; other site 1064551005155 product (indole) binding pocket [chemical binding]; other site 1064551005156 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1064551005157 active site 1064551005158 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1064551005159 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1064551005160 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551005161 catalytic residue [active] 1064551005162 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1064551005163 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1064551005164 substrate binding site [chemical binding]; other site 1064551005165 active site 1064551005166 catalytic residues [active] 1064551005167 heterodimer interface [polypeptide binding]; other site 1064551005168 General stress protein [General function prediction only]; Region: GsiB; COG3729 1064551005169 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 1064551005170 dimerization interface [polypeptide binding]; other site 1064551005171 metal binding site [ion binding]; metal-binding site 1064551005172 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1064551005173 dinuclear metal binding motif [ion binding]; other site 1064551005174 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1064551005175 dimanganese center [ion binding]; other site 1064551005176 outer membrane protein W; Provisional; Region: PRK10959 1064551005177 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 1064551005178 hypothetical protein; Provisional; Region: PRK02868 1064551005179 intracellular septation protein A; Reviewed; Region: PRK00259 1064551005180 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1064551005181 transport protein TonB; Provisional; Region: PRK10819 1064551005182 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1064551005183 YciI-like protein; Reviewed; Region: PRK11370 1064551005184 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1064551005185 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1064551005186 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 1064551005187 putative active site [active] 1064551005188 catalytic site [active] 1064551005189 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 1064551005190 putative active site [active] 1064551005191 catalytic site [active] 1064551005192 dsDNA-mimic protein; Reviewed; Region: PRK05094 1064551005193 Ion transport protein; Region: Ion_trans; pfam00520 1064551005194 Ion channel; Region: Ion_trans_2; pfam07885 1064551005195 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1064551005196 Double zinc ribbon; Region: DZR; pfam12773 1064551005197 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1064551005198 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1064551005199 Walker A/P-loop; other site 1064551005200 ATP binding site [chemical binding]; other site 1064551005201 Q-loop/lid; other site 1064551005202 ABC transporter signature motif; other site 1064551005203 Walker B; other site 1064551005204 D-loop; other site 1064551005205 H-loop/switch region; other site 1064551005206 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1064551005207 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 1064551005208 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1064551005209 Walker A/P-loop; other site 1064551005210 ATP binding site [chemical binding]; other site 1064551005211 Q-loop/lid; other site 1064551005212 ABC transporter signature motif; other site 1064551005213 Walker B; other site 1064551005214 D-loop; other site 1064551005215 H-loop/switch region; other site 1064551005216 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1064551005217 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1064551005218 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1064551005219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551005220 dimer interface [polypeptide binding]; other site 1064551005221 conserved gate region; other site 1064551005222 ABC-ATPase subunit interface; other site 1064551005223 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1064551005224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551005225 dimer interface [polypeptide binding]; other site 1064551005226 conserved gate region; other site 1064551005227 putative PBP binding loops; other site 1064551005228 ABC-ATPase subunit interface; other site 1064551005229 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1064551005230 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1064551005231 peptide binding site [polypeptide binding]; other site 1064551005232 hypothetical protein; Provisional; Region: PRK11111 1064551005233 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1064551005234 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1064551005235 putative catalytic cysteine [active] 1064551005236 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1064551005237 putative active site [active] 1064551005238 metal binding site [ion binding]; metal-binding site 1064551005239 thymidine kinase; Provisional; Region: PRK04296 1064551005240 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 1064551005241 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1064551005242 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1064551005243 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1064551005244 active site 1064551005245 tetramer interface; other site 1064551005246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064551005247 active site 1064551005248 response regulator of RpoS; Provisional; Region: PRK10693 1064551005249 phosphorylation site [posttranslational modification] 1064551005250 intermolecular recognition site; other site 1064551005251 dimerization interface [polypeptide binding]; other site 1064551005252 hypothetical protein; Provisional; Region: PRK10279 1064551005253 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1064551005254 active site 1064551005255 nucleophile elbow; other site 1064551005256 hypothetical protein; Provisional; Region: PRK01617 1064551005257 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1064551005258 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1064551005259 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1064551005260 putative active site [active] 1064551005261 putative substrate binding site [chemical binding]; other site 1064551005262 putative cosubstrate binding site; other site 1064551005263 catalytic site [active] 1064551005264 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1064551005265 Sel1-like repeats; Region: SEL1; smart00671 1064551005266 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1064551005267 Sel1-like repeats; Region: SEL1; smart00671 1064551005268 Sel1-like repeats; Region: SEL1; smart00671 1064551005269 Sel1-like repeats; Region: SEL1; smart00671 1064551005270 Sel1-like repeats; Region: SEL1; smart00671 1064551005271 Sel1-like repeats; Region: SEL1; smart00671 1064551005272 Sel1-like repeats; Region: SEL1; smart00671 1064551005273 Sel1-like repeats; Region: SEL1; smart00671 1064551005274 Sel1-like repeats; Region: SEL1; smart00671 1064551005275 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1064551005276 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1064551005277 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1064551005278 4Fe-4S binding domain; Region: Fer4; cl02805 1064551005279 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 1064551005280 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1064551005281 [4Fe-4S] binding site [ion binding]; other site 1064551005282 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1064551005283 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1064551005284 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1064551005285 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1064551005286 molybdopterin cofactor binding site; other site 1064551005287 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1064551005288 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 1064551005289 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1064551005290 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064551005291 dimerization interface [polypeptide binding]; other site 1064551005292 Histidine kinase; Region: HisKA_3; pfam07730 1064551005293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064551005294 ATP binding site [chemical binding]; other site 1064551005295 Mg2+ binding site [ion binding]; other site 1064551005296 G-X-G motif; other site 1064551005297 transcriptional regulator NarL; Provisional; Region: PRK10651 1064551005298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064551005299 active site 1064551005300 phosphorylation site [posttranslational modification] 1064551005301 intermolecular recognition site; other site 1064551005302 dimerization interface [polypeptide binding]; other site 1064551005303 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064551005304 DNA binding residues [nucleotide binding] 1064551005305 dimerization interface [polypeptide binding]; other site 1064551005306 putative invasin; Provisional; Region: PRK10177 1064551005307 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1064551005308 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 1064551005309 cation transport regulator; Reviewed; Region: chaB; PRK09582 1064551005310 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 1064551005311 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1064551005312 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 1064551005313 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1064551005314 hypothetical protein; Provisional; Region: PRK10941 1064551005315 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1064551005316 hypothetical protein; Provisional; Region: PRK10278 1064551005317 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1064551005318 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064551005319 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1064551005320 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1064551005321 RF-1 domain; Region: RF-1; pfam00472 1064551005322 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1064551005323 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1064551005324 tRNA; other site 1064551005325 putative tRNA binding site [nucleotide binding]; other site 1064551005326 putative NADP binding site [chemical binding]; other site 1064551005327 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1064551005328 Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017 1064551005329 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1064551005330 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1064551005331 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1064551005332 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1064551005333 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1064551005334 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1064551005335 active site 1064551005336 putative transporter; Provisional; Region: PRK11660 1064551005337 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1064551005338 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1064551005339 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1064551005340 hypothetical protein; Provisional; Region: PRK10692 1064551005341 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1064551005342 putative active site [active] 1064551005343 catalytic residue [active] 1064551005344 GTP-binding protein YchF; Reviewed; Region: PRK09601 1064551005345 YchF GTPase; Region: YchF; cd01900 1064551005346 G1 box; other site 1064551005347 GTP/Mg2+ binding site [chemical binding]; other site 1064551005348 Switch I region; other site 1064551005349 G2 box; other site 1064551005350 Switch II region; other site 1064551005351 G3 box; other site 1064551005352 G4 box; other site 1064551005353 G5 box; other site 1064551005354 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1064551005355 Protein of unknown function (DUF2743); Region: DUF2743; pfam10899 1064551005356 Protein of unknown function (DUF4427); Region: DUF4427; pfam14468 1064551005357 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 1064551005358 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1064551005359 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1064551005360 hydrogenase 1 large subunit; Provisional; Region: PRK10170 1064551005361 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1064551005362 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 1064551005363 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1064551005364 putative substrate-binding site; other site 1064551005365 nickel binding site [ion binding]; other site 1064551005366 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 1064551005367 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 1064551005368 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 1064551005369 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 1064551005370 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1064551005371 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 1064551005372 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1064551005373 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 1064551005374 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1064551005375 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1064551005376 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1064551005377 NAD(P) binding site [chemical binding]; other site 1064551005378 trehalase; Provisional; Region: treA; PRK13271 1064551005379 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 1064551005380 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1064551005381 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1064551005382 Flagellar regulator YcgR; Region: YcgR; pfam07317 1064551005383 PilZ domain; Region: PilZ; pfam07238 1064551005384 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 1064551005385 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1064551005386 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1064551005387 catalytic residue [active] 1064551005388 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1064551005389 dimer interface [polypeptide binding]; other site 1064551005390 catalytic triad [active] 1064551005391 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 1064551005392 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1064551005393 TrkA-C domain; Region: TrkA_C; pfam02080 1064551005394 Transporter associated domain; Region: CorC_HlyC; smart01091 1064551005395 alanine racemase; Reviewed; Region: dadX; PRK03646 1064551005396 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1064551005397 active site 1064551005398 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1064551005399 substrate binding site [chemical binding]; other site 1064551005400 catalytic residues [active] 1064551005401 dimer interface [polypeptide binding]; other site 1064551005402 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1064551005403 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1064551005404 SpoVR family protein; Provisional; Region: PRK11767 1064551005405 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1064551005406 fatty acid metabolism regulator; Provisional; Region: PRK04984 1064551005407 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064551005408 DNA-binding site [nucleotide binding]; DNA binding site 1064551005409 FadR C-terminal domain; Region: FadR_C; pfam07840 1064551005410 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1064551005411 transmembrane helices; other site 1064551005412 disulfide bond formation protein B; Provisional; Region: PRK01749 1064551005413 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 1064551005414 GnsA/GnsB family; Region: GnsAB; pfam08178 1064551005415 hypothetical protein; Provisional; Region: PRK05170 1064551005416 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1064551005417 hypothetical protein; Provisional; Region: PRK10691 1064551005418 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 1064551005419 septum formation inhibitor; Reviewed; Region: minC; PRK03511 1064551005420 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1064551005421 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1064551005422 cell division inhibitor MinD; Provisional; Region: PRK10818 1064551005423 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1064551005424 Switch I; other site 1064551005425 Switch II; other site 1064551005426 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1064551005427 ribonuclease D; Provisional; Region: PRK10829 1064551005428 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1064551005429 catalytic site [active] 1064551005430 putative active site [active] 1064551005431 putative substrate binding site [chemical binding]; other site 1064551005432 HRDC domain; Region: HRDC; cl02578 1064551005433 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 1064551005434 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1064551005435 acyl-activating enzyme (AAE) consensus motif; other site 1064551005436 putative AMP binding site [chemical binding]; other site 1064551005437 putative active site [active] 1064551005438 putative CoA binding site [chemical binding]; other site 1064551005439 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 1064551005440 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 1064551005441 Glycoprotease family; Region: Peptidase_M22; pfam00814 1064551005442 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1064551005443 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1064551005444 DEAD_2; Region: DEAD_2; pfam06733 1064551005445 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1064551005446 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1064551005447 homotrimer interaction site [polypeptide binding]; other site 1064551005448 putative active site [active] 1064551005449 hypothetical protein; Provisional; Region: PRK05114 1064551005450 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 1064551005451 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1064551005452 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 1064551005453 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1064551005454 putative active site [active] 1064551005455 putative CoA binding site [chemical binding]; other site 1064551005456 nudix motif; other site 1064551005457 metal binding site [ion binding]; metal-binding site 1064551005458 L-serine deaminase; Provisional; Region: PRK15023 1064551005459 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1064551005460 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1064551005461 phage resistance protein; Provisional; Region: PRK10551 1064551005462 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1064551005463 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1064551005464 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1064551005465 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1064551005466 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1064551005467 Transporter associated domain; Region: CorC_HlyC; smart01091 1064551005468 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1064551005469 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1064551005470 active pocket/dimerization site; other site 1064551005471 active site 1064551005472 phosphorylation site [posttranslational modification] 1064551005473 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1064551005474 active site 1064551005475 phosphorylation site [posttranslational modification] 1064551005476 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1064551005477 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 1064551005478 hypothetical protein; Provisional; Region: PRK02913 1064551005479 hypothetical protein; Provisional; Region: PRK11469 1064551005480 Domain of unknown function DUF; Region: DUF204; pfam02659 1064551005481 Domain of unknown function DUF; Region: DUF204; pfam02659 1064551005482 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1064551005483 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064551005484 S-adenosylmethionine binding site [chemical binding]; other site 1064551005485 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1064551005486 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1064551005487 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1064551005488 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1064551005489 DNA-binding site [nucleotide binding]; DNA binding site 1064551005490 RNA-binding motif; other site 1064551005491 YebO-like protein; Region: YebO; pfam13974 1064551005492 PhoPQ regulatory protein; Provisional; Region: PRK10299 1064551005493 YobH-like protein; Region: YobH; pfam13996 1064551005494 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 1064551005495 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1064551005496 dimerization interface [polypeptide binding]; other site 1064551005497 putative Zn2+ binding site [ion binding]; other site 1064551005498 putative DNA binding site [nucleotide binding]; other site 1064551005499 Bacterial transcriptional regulator; Region: IclR; pfam01614 1064551005500 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551005501 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1064551005502 putative substrate translocation pore; other site 1064551005503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551005504 heat shock protein HtpX; Provisional; Region: PRK05457 1064551005505 carboxy-terminal protease; Provisional; Region: PRK11186 1064551005506 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1064551005507 protein binding site [polypeptide binding]; other site 1064551005508 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1064551005509 Catalytic dyad [active] 1064551005510 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 1064551005511 ProP expression regulator; Provisional; Region: PRK04950 1064551005512 ProQ/FINO family; Region: ProQ; pfam04352 1064551005513 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1064551005514 GAF domain; Region: GAF_2; pfam13185 1064551005515 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 1064551005516 Paraquat-inducible protein A; Region: PqiA; pfam04403 1064551005517 Paraquat-inducible protein A; Region: PqiA; pfam04403 1064551005518 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1064551005519 mce related protein; Region: MCE; pfam02470 1064551005520 mce related protein; Region: MCE; pfam02470 1064551005521 mce related protein; Region: MCE; pfam02470 1064551005522 mce related protein; Region: MCE; pfam02470 1064551005523 mce related protein; Region: MCE; pfam02470 1064551005524 mce related protein; Region: MCE; pfam02470 1064551005525 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 1064551005526 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1064551005527 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1064551005528 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 1064551005529 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 1064551005530 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 1064551005531 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1064551005532 type III secretion protein SopE2; Provisional; Region: PRK15280 1064551005533 Salmonella type III secretion SopE effector N-terminus; Region: SecIII_SopE_N; pfam05364 1064551005534 SopE GEF domain; Region: SopE_GEF; pfam07487 1064551005535 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 1064551005536 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064551005537 Coenzyme A binding pocket [chemical binding]; other site 1064551005538 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1064551005539 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1064551005540 DNA binding site [nucleotide binding] 1064551005541 active site 1064551005542 Int/Topo IB signature motif; other site 1064551005543 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1064551005544 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1064551005545 EamA-like transporter family; Region: EamA; pfam00892 1064551005546 EamA-like transporter family; Region: EamA; pfam00892 1064551005547 Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495 1064551005548 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1064551005549 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 1064551005550 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 1064551005551 exonuclease VIII; Reviewed; Region: PRK09709 1064551005552 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 1064551005553 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1064551005554 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 1064551005555 dimer interface [polypeptide binding]; other site 1064551005556 active site 1064551005557 Int/Topo IB signature motif; other site 1064551005558 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 1064551005559 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1064551005560 hypothetical protein; Provisional; Region: PRK10301 1064551005561 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 1064551005562 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1064551005563 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 1064551005564 exodeoxyribonuclease X; Provisional; Region: PRK07983 1064551005565 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1064551005566 active site 1064551005567 catalytic site [active] 1064551005568 substrate binding site [chemical binding]; other site 1064551005569 protease 2; Provisional; Region: PRK10115 1064551005570 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1064551005571 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 1064551005572 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1064551005573 putative metal binding site [ion binding]; other site 1064551005574 hypothetical protein; Provisional; Region: PRK13680 1064551005575 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 1064551005576 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1064551005577 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1064551005578 ATP-grasp domain; Region: ATP-grasp; pfam02222 1064551005579 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1064551005580 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1064551005581 active site 1064551005582 intersubunit interface [polypeptide binding]; other site 1064551005583 catalytic residue [active] 1064551005584 phosphogluconate dehydratase; Validated; Region: PRK09054 1064551005585 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1064551005586 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1064551005587 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1064551005588 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1064551005589 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1064551005590 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1064551005591 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1064551005592 putative active site [active] 1064551005593 pyruvate kinase; Provisional; Region: PRK05826 1064551005594 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1064551005595 domain interfaces; other site 1064551005596 active site 1064551005597 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1064551005598 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1064551005599 putative acyl-acceptor binding pocket; other site 1064551005600 putative peptidase; Provisional; Region: PRK11649 1064551005601 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 1064551005602 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1064551005603 Peptidase family M23; Region: Peptidase_M23; pfam01551 1064551005604 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 1064551005605 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1064551005606 metal binding site [ion binding]; metal-binding site 1064551005607 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 1064551005608 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1064551005609 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1064551005610 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1064551005611 ABC-ATPase subunit interface; other site 1064551005612 dimer interface [polypeptide binding]; other site 1064551005613 putative PBP binding regions; other site 1064551005614 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1064551005615 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064551005616 Walker A motif; other site 1064551005617 ATP binding site [chemical binding]; other site 1064551005618 Walker B motif; other site 1064551005619 arginine finger; other site 1064551005620 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1064551005621 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1064551005622 RuvA N terminal domain; Region: RuvA_N; pfam01330 1064551005623 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1064551005624 hypothetical protein; Provisional; Region: PRK11470 1064551005625 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1064551005626 active site 1064551005627 putative DNA-binding cleft [nucleotide binding]; other site 1064551005628 dimer interface [polypeptide binding]; other site 1064551005629 hypothetical protein; Validated; Region: PRK00110 1064551005630 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 1064551005631 nudix motif; other site 1064551005632 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1064551005633 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1064551005634 dimer interface [polypeptide binding]; other site 1064551005635 anticodon binding site; other site 1064551005636 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1064551005637 homodimer interface [polypeptide binding]; other site 1064551005638 motif 1; other site 1064551005639 active site 1064551005640 motif 2; other site 1064551005641 GAD domain; Region: GAD; pfam02938 1064551005642 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1064551005643 active site 1064551005644 motif 3; other site 1064551005645 Isochorismatase family; Region: Isochorismatase; pfam00857 1064551005646 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1064551005647 catalytic triad [active] 1064551005648 conserved cis-peptide bond; other site 1064551005649 hypothetical protein; Provisional; Region: PRK10302 1064551005650 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 1064551005651 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064551005652 S-adenosylmethionine binding site [chemical binding]; other site 1064551005653 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064551005654 S-adenosylmethionine binding site [chemical binding]; other site 1064551005655 copper homeostasis protein CutC; Provisional; Region: PRK11572 1064551005656 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 1064551005657 putative metal binding site [ion binding]; other site 1064551005658 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1064551005659 arginyl-tRNA synthetase; Region: argS; TIGR00456 1064551005660 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1064551005661 active site 1064551005662 HIGH motif; other site 1064551005663 KMSK motif region; other site 1064551005664 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1064551005665 tRNA binding surface [nucleotide binding]; other site 1064551005666 anticodon binding site; other site 1064551005667 penicillin-binding protein 2; Provisional; Region: PRK10795 1064551005668 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1064551005669 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1064551005670 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1064551005671 Flagellar protein FlhE; Region: FlhE; pfam06366 1064551005672 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1064551005673 FHIPEP family; Region: FHIPEP; pfam00771 1064551005674 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1064551005675 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1064551005676 chemotaxis regulator CheZ; Provisional; Region: PRK11166 1064551005677 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1064551005678 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064551005679 active site 1064551005680 phosphorylation site [posttranslational modification] 1064551005681 intermolecular recognition site; other site 1064551005682 dimerization interface [polypeptide binding]; other site 1064551005683 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1064551005684 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064551005685 active site 1064551005686 phosphorylation site [posttranslational modification] 1064551005687 intermolecular recognition site; other site 1064551005688 dimerization interface [polypeptide binding]; other site 1064551005689 CheB methylesterase; Region: CheB_methylest; pfam01339 1064551005690 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 1064551005691 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1064551005692 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064551005693 S-adenosylmethionine binding site [chemical binding]; other site 1064551005694 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 1064551005695 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1064551005696 dimer interface [polypeptide binding]; other site 1064551005697 ligand binding site [chemical binding]; other site 1064551005698 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064551005699 dimerization interface [polypeptide binding]; other site 1064551005700 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064551005701 dimer interface [polypeptide binding]; other site 1064551005702 putative CheW interface [polypeptide binding]; other site 1064551005703 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1064551005704 putative CheA interaction surface; other site 1064551005705 chemotaxis protein CheA; Provisional; Region: PRK10547 1064551005706 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1064551005707 putative binding surface; other site 1064551005708 active site 1064551005709 CheY binding; Region: CheY-binding; pfam09078 1064551005710 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1064551005711 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064551005712 ATP binding site [chemical binding]; other site 1064551005713 Mg2+ binding site [ion binding]; other site 1064551005714 G-X-G motif; other site 1064551005715 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1064551005716 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1064551005717 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1064551005718 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1064551005719 ligand binding site [chemical binding]; other site 1064551005720 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1064551005721 flagellar motor protein MotA; Validated; Region: PRK09110 1064551005722 transcriptional activator FlhC; Provisional; Region: PRK12722 1064551005723 transcriptional activator FlhD; Provisional; Region: PRK02909 1064551005724 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1064551005725 Ligand Binding Site [chemical binding]; other site 1064551005726 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1064551005727 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1064551005728 active site 1064551005729 homotetramer interface [polypeptide binding]; other site 1064551005730 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 1064551005731 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1064551005732 DJ-1 family protein; Region: not_thiJ; TIGR01383 1064551005733 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1064551005734 conserved cys residue [active] 1064551005735 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1064551005736 Ferritin-like domain; Region: Ferritin; pfam00210 1064551005737 ferroxidase diiron center [ion binding]; other site 1064551005738 hypothetical protein; Provisional; Region: PRK09273 1064551005739 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 1064551005740 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 1064551005741 YecR-like lipoprotein; Region: YecR; pfam13992 1064551005742 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1064551005743 Ferritin-like domain; Region: Ferritin; pfam00210 1064551005744 ferroxidase diiron center [ion binding]; other site 1064551005745 probable metal-binding protein; Region: matur_matur; TIGR03853 1064551005746 tyrosine transporter TyrP; Provisional; Region: PRK15132 1064551005747 aromatic amino acid transport protein; Region: araaP; TIGR00837 1064551005748 hypothetical protein; Provisional; Region: PRK10396 1064551005749 yecA family protein; Region: ygfB_yecA; TIGR02292 1064551005750 SEC-C motif; Region: SEC-C; pfam02810 1064551005751 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 1064551005752 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 1064551005753 NlpC/P60 family; Region: NLPC_P60; cl17555 1064551005754 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 1064551005755 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1064551005756 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1064551005757 GIY-YIG motif/motif A; other site 1064551005758 active site 1064551005759 catalytic site [active] 1064551005760 putative DNA binding site [nucleotide binding]; other site 1064551005761 metal binding site [ion binding]; metal-binding site 1064551005762 UvrB/uvrC motif; Region: UVR; pfam02151 1064551005763 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1064551005764 Helix-hairpin-helix motif; Region: HHH; pfam00633 1064551005765 response regulator; Provisional; Region: PRK09483 1064551005766 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064551005767 active site 1064551005768 phosphorylation site [posttranslational modification] 1064551005769 intermolecular recognition site; other site 1064551005770 dimerization interface [polypeptide binding]; other site 1064551005771 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064551005772 DNA binding residues [nucleotide binding] 1064551005773 dimerization interface [polypeptide binding]; other site 1064551005774 hypothetical protein; Provisional; Region: PRK10613 1064551005775 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 1064551005776 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1064551005777 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064551005778 DNA binding residues [nucleotide binding] 1064551005779 dimerization interface [polypeptide binding]; other site 1064551005780 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 1064551005781 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1064551005782 Walker A/P-loop; other site 1064551005783 ATP binding site [chemical binding]; other site 1064551005784 Q-loop/lid; other site 1064551005785 ABC transporter signature motif; other site 1064551005786 Walker B; other site 1064551005787 D-loop; other site 1064551005788 H-loop/switch region; other site 1064551005789 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1064551005790 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1064551005791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551005792 dimer interface [polypeptide binding]; other site 1064551005793 conserved gate region; other site 1064551005794 putative PBP binding loops; other site 1064551005795 ABC-ATPase subunit interface; other site 1064551005796 D-cysteine desulfhydrase; Validated; Region: PRK03910 1064551005797 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 1064551005798 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551005799 catalytic residue [active] 1064551005800 cystine transporter subunit; Provisional; Region: PRK11260 1064551005801 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064551005802 substrate binding pocket [chemical binding]; other site 1064551005803 membrane-bound complex binding site; other site 1064551005804 hinge residues; other site 1064551005805 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 1064551005806 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 1064551005807 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1064551005808 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1064551005809 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1064551005810 DNA binding residues [nucleotide binding] 1064551005811 flagellin; Validated; Region: PRK08026 1064551005812 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1064551005813 Flagellin D3 domain; Region: Flagellin_D3; pfam08884 1064551005814 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1064551005815 flagellar capping protein; Reviewed; Region: fliD; PRK08032 1064551005816 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1064551005817 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1064551005818 flagellar protein FliS; Validated; Region: fliS; PRK05685 1064551005819 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 1064551005820 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 1064551005821 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 1064551005822 active site 1064551005823 Na/Ca binding site [ion binding]; other site 1064551005824 catalytic site [active] 1064551005825 lipoprotein; Provisional; Region: PRK10397 1064551005826 putative inner membrane protein; Provisional; Region: PRK11099 1064551005827 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 1064551005828 CPxP motif; other site 1064551005829 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 1064551005830 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1064551005831 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1064551005832 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1064551005833 flagellar motor switch protein FliG; Region: fliG; TIGR00207 1064551005834 FliG C-terminal domain; Region: FliG_C; pfam01706 1064551005835 flagellar assembly protein H; Validated; Region: fliH; PRK05687 1064551005836 Flagellar assembly protein FliH; Region: FliH; pfam02108 1064551005837 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 1064551005838 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1064551005839 Walker A motif/ATP binding site; other site 1064551005840 Walker B motif; other site 1064551005841 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1064551005842 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 1064551005843 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 1064551005844 flagellar hook-length control protein; Provisional; Region: PRK10118 1064551005845 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 1064551005846 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1064551005847 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1064551005848 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 1064551005849 flagellar motor switch protein; Validated; Region: fliN; PRK05698 1064551005850 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 1064551005851 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1064551005852 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1064551005853 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1064551005854 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 1064551005855 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064551005856 DNA binding residues [nucleotide binding] 1064551005857 dimerization interface [polypeptide binding]; other site 1064551005858 hypothetical protein; Provisional; Region: PRK10708 1064551005859 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 1064551005860 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 1064551005861 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064551005862 active site 1064551005863 motif I; other site 1064551005864 motif II; other site 1064551005865 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 1064551005866 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064551005867 metal binding site [ion binding]; metal-binding site 1064551005868 active site 1064551005869 I-site; other site 1064551005870 Uncharacterized small protein [Function unknown]; Region: COG5475 1064551005871 hypothetical protein; Provisional; Region: PRK10062 1064551005872 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1064551005873 EamA-like transporter family; Region: EamA; pfam00892 1064551005874 EamA-like transporter family; Region: EamA; pfam00892 1064551005875 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1064551005876 additional DNA contacts [nucleotide binding]; other site 1064551005877 mismatch recognition site; other site 1064551005878 active site 1064551005879 zinc binding site [ion binding]; other site 1064551005880 DNA intercalation site [nucleotide binding]; other site 1064551005881 DNA cytosine methylase; Provisional; Region: PRK10458 1064551005882 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1064551005883 cofactor binding site; other site 1064551005884 DNA binding site [nucleotide binding] 1064551005885 substrate interaction site [chemical binding]; other site 1064551005886 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1064551005887 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1064551005888 Zn2+ binding site [ion binding]; other site 1064551005889 Mg2+ binding site [ion binding]; other site 1064551005890 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1064551005891 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1064551005892 trimer interface [polypeptide binding]; other site 1064551005893 eyelet of channel; other site 1064551005894 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1064551005895 DNA-binding site [nucleotide binding]; DNA binding site 1064551005896 RNA-binding motif; other site 1064551005897 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1064551005898 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1064551005899 active site 1064551005900 DNA binding site [nucleotide binding] 1064551005901 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1064551005902 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1064551005903 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1064551005904 Catalytic site [active] 1064551005905 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 1064551005906 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1064551005907 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 1064551005908 putative protease; Region: PHA00666 1064551005909 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 1064551005910 Integrase; Region: Integrase_1; pfam12835 1064551005911 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1064551005912 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1064551005913 Sel1 repeat; Region: Sel1; pfam08238 1064551005914 Sel1-like repeats; Region: SEL1; smart00671 1064551005915 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 1064551005916 AMP nucleosidase; Provisional; Region: PRK08292 1064551005917 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1064551005918 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1064551005919 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1064551005920 MATE family multidrug exporter; Provisional; Region: PRK10189 1064551005921 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 1064551005922 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 1064551005923 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1064551005924 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1064551005925 Sodium Bile acid symporter family; Region: SBF; cl17470 1064551005926 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 1064551005927 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1064551005928 P loop; other site 1064551005929 Nucleotide binding site [chemical binding]; other site 1064551005930 DTAP/Switch II; other site 1064551005931 Switch I; other site 1064551005932 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1064551005933 P loop; other site 1064551005934 Nucleotide binding site [chemical binding]; other site 1064551005935 DTAP/Switch II; other site 1064551005936 Switch I; other site 1064551005937 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 1064551005938 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1064551005939 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1064551005940 active site 1064551005941 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1064551005942 dimerization interface [polypeptide binding]; other site 1064551005943 putative DNA binding site [nucleotide binding]; other site 1064551005944 putative Zn2+ binding site [ion binding]; other site 1064551005945 L,D-transpeptidase; Provisional; Region: PRK10190 1064551005946 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1064551005947 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1064551005948 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1064551005949 putative dimer interface [polypeptide binding]; other site 1064551005950 active site pocket [active] 1064551005951 putative cataytic base [active] 1064551005952 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1064551005953 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1064551005954 homotrimer interface [polypeptide binding]; other site 1064551005955 Walker A motif; other site 1064551005956 GTP binding site [chemical binding]; other site 1064551005957 Walker B motif; other site 1064551005958 cobyric acid synthase; Provisional; Region: PRK00784 1064551005959 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1064551005960 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1064551005961 catalytic triad [active] 1064551005962 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 1064551005963 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1064551005964 Walker A/P-loop; other site 1064551005965 ATP binding site [chemical binding]; other site 1064551005966 Q-loop/lid; other site 1064551005967 ABC transporter signature motif; other site 1064551005968 Walker B; other site 1064551005969 D-loop; other site 1064551005970 H-loop/switch region; other site 1064551005971 cobalt transport protein CbiQ; Provisional; Region: PRK15485 1064551005972 cobalt transport protein CbiN; Provisional; Region: PRK02898 1064551005973 cobalt transport protein CbiM; Validated; Region: PRK08319 1064551005974 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1064551005975 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1064551005976 active site 1064551005977 SAM binding site [chemical binding]; other site 1064551005978 homodimer interface [polypeptide binding]; other site 1064551005979 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 1064551005980 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 1064551005981 active site 1064551005982 C-terminal domain interface [polypeptide binding]; other site 1064551005983 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 1064551005984 active site 1064551005985 N-terminal domain interface [polypeptide binding]; other site 1064551005986 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1064551005987 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 1064551005988 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1064551005989 active site 1064551005990 SAM binding site [chemical binding]; other site 1064551005991 homodimer interface [polypeptide binding]; other site 1064551005992 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 1064551005993 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 1064551005994 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 1064551005995 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1064551005996 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1064551005997 active site 1064551005998 SAM binding site [chemical binding]; other site 1064551005999 homodimer interface [polypeptide binding]; other site 1064551006000 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 1064551006001 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064551006002 S-adenosylmethionine binding site [chemical binding]; other site 1064551006003 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1064551006004 active site 1064551006005 putative homodimer interface [polypeptide binding]; other site 1064551006006 SAM binding site [chemical binding]; other site 1064551006007 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 1064551006008 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 1064551006009 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1064551006010 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1064551006011 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1064551006012 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1064551006013 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1064551006014 catalytic triad [active] 1064551006015 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 1064551006016 Sensory domain found in PocR; Region: PocR; pfam10114 1064551006017 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064551006018 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1064551006019 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064551006020 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1064551006021 amphipathic channel; other site 1064551006022 Asn-Pro-Ala signature motifs; other site 1064551006023 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1064551006024 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 1064551006025 Hexamer interface [polypeptide binding]; other site 1064551006026 Putative hexagonal pore residue; other site 1064551006027 propanediol utilization protein PduB; Provisional; Region: PRK15415 1064551006028 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 1064551006029 putative hexamer interface [polypeptide binding]; other site 1064551006030 putative hexagonal pore; other site 1064551006031 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 1064551006032 putative hexamer interface [polypeptide binding]; other site 1064551006033 putative hexagonal pore; other site 1064551006034 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 1064551006035 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 1064551006036 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 1064551006037 alpha-beta subunit interface [polypeptide binding]; other site 1064551006038 alpha-gamma subunit interface [polypeptide binding]; other site 1064551006039 active site 1064551006040 substrate and K+ binding site; other site 1064551006041 K+ binding site [ion binding]; other site 1064551006042 cobalamin binding site [chemical binding]; other site 1064551006043 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 1064551006044 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 1064551006045 Cell division protein FtsA; Region: FtsA; cl17206 1064551006046 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 1064551006047 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 1064551006048 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1064551006049 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 1064551006050 Hexamer interface [polypeptide binding]; other site 1064551006051 Putative hexagonal pore residue; other site 1064551006052 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1064551006053 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 1064551006054 putative hexamer interface [polypeptide binding]; other site 1064551006055 putative hexagonal pore; other site 1064551006056 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 1064551006057 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1064551006058 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1064551006059 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 1064551006060 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1064551006061 Hexamer/Pentamer interface [polypeptide binding]; other site 1064551006062 central pore; other site 1064551006063 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1064551006064 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 1064551006065 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 1064551006066 putative catalytic cysteine [active] 1064551006067 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1064551006068 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 1064551006069 putative active site [active] 1064551006070 metal binding site [ion binding]; metal-binding site 1064551006071 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 1064551006072 SLBB domain; Region: SLBB; pfam10531 1064551006073 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 1064551006074 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 1064551006075 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 1064551006076 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 1064551006077 putative hexamer interface [polypeptide binding]; other site 1064551006078 putative hexagonal pore; other site 1064551006079 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 1064551006080 putative hexamer interface [polypeptide binding]; other site 1064551006081 putative hexagonal pore; other site 1064551006082 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 1064551006083 putative hexamer interface [polypeptide binding]; other site 1064551006084 putative hexagonal pore; other site 1064551006085 Ethanolamine utilisation - propanediol utilisation; Region: PduV-EutP; pfam10662 1064551006086 G3 box; other site 1064551006087 Switch II region; other site 1064551006088 GTP/Mg2+ binding site [chemical binding]; other site 1064551006089 G4 box; other site 1064551006090 G5 box; other site 1064551006091 propionate kinase; Reviewed; Region: PRK12397 1064551006092 propionate/acetate kinase; Provisional; Region: PRK12379 1064551006093 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 1064551006094 hypothetical protein; Provisional; Region: PRK05423 1064551006095 Predicted membrane protein [Function unknown]; Region: COG1289 1064551006096 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1064551006097 DNA gyrase inhibitor; Provisional; Region: PRK10016 1064551006098 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 1064551006099 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1064551006100 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1064551006101 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 1064551006102 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 1064551006103 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 1064551006104 4Fe-4S binding domain; Region: Fer4; cl02805 1064551006105 thiosulfate reductase PhsA; Provisional; Region: PRK15488 1064551006106 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1064551006107 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 1064551006108 putative [Fe4-S4] binding site [ion binding]; other site 1064551006109 putative molybdopterin cofactor binding site [chemical binding]; other site 1064551006110 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1064551006111 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 1064551006112 putative molybdopterin cofactor binding site; other site 1064551006113 E3 ubiquitin-protein ligase SopA; Provisional; Region: PRK15377 1064551006114 SopA-like central domain; Region: SopA; pfam13981 1064551006115 SopA-like catalytic domain; Region: SopA_C; pfam13979 1064551006116 exonuclease I; Provisional; Region: sbcB; PRK11779 1064551006117 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1064551006118 active site 1064551006119 catalytic site [active] 1064551006120 substrate binding site [chemical binding]; other site 1064551006121 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1064551006122 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1064551006123 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064551006124 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551006125 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1064551006126 dimerization interface [polypeptide binding]; other site 1064551006127 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1064551006128 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1064551006129 putative NAD(P) binding site [chemical binding]; other site 1064551006130 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1064551006131 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1064551006132 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1064551006133 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1064551006134 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1064551006135 NAD binding site [chemical binding]; other site 1064551006136 dimerization interface [polypeptide binding]; other site 1064551006137 product binding site; other site 1064551006138 substrate binding site [chemical binding]; other site 1064551006139 zinc binding site [ion binding]; other site 1064551006140 catalytic residues [active] 1064551006141 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 1064551006142 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1064551006143 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551006144 homodimer interface [polypeptide binding]; other site 1064551006145 catalytic residue [active] 1064551006146 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 1064551006147 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064551006148 active site 1064551006149 motif I; other site 1064551006150 motif II; other site 1064551006151 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1064551006152 putative active site pocket [active] 1064551006153 4-fold oligomerization interface [polypeptide binding]; other site 1064551006154 metal binding residues [ion binding]; metal-binding site 1064551006155 3-fold/trimer interface [polypeptide binding]; other site 1064551006156 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 1064551006157 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1064551006158 putative active site [active] 1064551006159 oxyanion strand; other site 1064551006160 catalytic triad [active] 1064551006161 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1064551006162 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1064551006163 catalytic residues [active] 1064551006164 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1064551006165 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1064551006166 substrate binding site [chemical binding]; other site 1064551006167 glutamase interaction surface [polypeptide binding]; other site 1064551006168 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1064551006169 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1064551006170 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1064551006171 metal binding site [ion binding]; metal-binding site 1064551006172 chain length determinant protein WzzB; Provisional; Region: PRK15471 1064551006173 Chain length determinant protein; Region: Wzz; pfam02706 1064551006174 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1064551006175 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 1064551006176 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1064551006177 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1064551006178 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1064551006179 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1064551006180 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1064551006181 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1064551006182 phosphomannomutase CpsG; Provisional; Region: PRK15414 1064551006183 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1064551006184 active site 1064551006185 substrate binding site [chemical binding]; other site 1064551006186 metal binding site [ion binding]; metal-binding site 1064551006187 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1064551006188 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1064551006189 Substrate binding site; other site 1064551006190 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1064551006191 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 1064551006192 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1064551006193 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064551006194 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064551006195 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064551006196 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064551006197 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1064551006198 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1064551006199 active site 1064551006200 tetramer interface; other site 1064551006201 colanic acid biosynthesis protein WcaM; Region: WcaM; TIGR04004 1064551006202 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 1064551006203 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 1064551006204 putative ADP-binding pocket [chemical binding]; other site 1064551006205 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1064551006206 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 1064551006207 colanic acid exporter; Provisional; Region: PRK10459 1064551006208 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1064551006209 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 1064551006210 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1064551006211 phosphomannomutase CpsG; Provisional; Region: PRK15414 1064551006212 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1064551006213 active site 1064551006214 substrate binding site [chemical binding]; other site 1064551006215 metal binding site [ion binding]; metal-binding site 1064551006216 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 1064551006217 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1064551006218 Substrate binding site; other site 1064551006219 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1064551006220 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 1064551006221 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1064551006222 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 1064551006223 active site 1064551006224 GDP-Mannose binding site [chemical binding]; other site 1064551006225 dimer interface [polypeptide binding]; other site 1064551006226 modified nudix motif 1064551006227 metal binding site [ion binding]; metal-binding site 1064551006228 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1064551006229 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1064551006230 NADP binding site [chemical binding]; other site 1064551006231 active site 1064551006232 putative substrate binding site [chemical binding]; other site 1064551006233 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1064551006234 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1064551006235 NADP-binding site; other site 1064551006236 homotetramer interface [polypeptide binding]; other site 1064551006237 substrate binding site [chemical binding]; other site 1064551006238 homodimer interface [polypeptide binding]; other site 1064551006239 active site 1064551006240 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 1064551006241 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 1064551006242 putative trimer interface [polypeptide binding]; other site 1064551006243 putative active site [active] 1064551006244 putative substrate binding site [chemical binding]; other site 1064551006245 putative CoA binding site [chemical binding]; other site 1064551006246 putative glycosyl transferase; Provisional; Region: PRK10063 1064551006247 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1064551006248 metal-binding site 1064551006249 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 1064551006250 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 1064551006251 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064551006252 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064551006253 putative acyl transferase; Provisional; Region: PRK10191 1064551006254 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1064551006255 trimer interface [polypeptide binding]; other site 1064551006256 active site 1064551006257 substrate binding site [chemical binding]; other site 1064551006258 CoA binding site [chemical binding]; other site 1064551006259 putative glycosyl transferase; Provisional; Region: PRK10018 1064551006260 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1064551006261 active site 1064551006262 tyrosine kinase; Provisional; Region: PRK11519 1064551006263 Chain length determinant protein; Region: Wzz; pfam02706 1064551006264 Chain length determinant protein; Region: Wzz; cl15801 1064551006265 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1064551006266 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1064551006267 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1064551006268 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1064551006269 active site 1064551006270 polysaccharide export protein Wza; Provisional; Region: PRK15078 1064551006271 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1064551006272 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1064551006273 FOG: CBS domain [General function prediction only]; Region: COG0517 1064551006274 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1064551006275 Transporter associated domain; Region: CorC_HlyC; smart01091 1064551006276 putative assembly protein; Provisional; Region: PRK10833 1064551006277 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1064551006278 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1064551006279 trimer interface [polypeptide binding]; other site 1064551006280 active site 1064551006281 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1064551006282 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1064551006283 ATP-binding site [chemical binding]; other site 1064551006284 Sugar specificity; other site 1064551006285 Pyrimidine base specificity; other site 1064551006286 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 1064551006287 PAS domain S-box; Region: sensory_box; TIGR00229 1064551006288 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064551006289 putative active site [active] 1064551006290 heme pocket [chemical binding]; other site 1064551006291 PAS domain S-box; Region: sensory_box; TIGR00229 1064551006292 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064551006293 putative active site [active] 1064551006294 heme pocket [chemical binding]; other site 1064551006295 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1064551006296 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064551006297 metal binding site [ion binding]; metal-binding site 1064551006298 active site 1064551006299 I-site; other site 1064551006300 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1064551006301 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 1064551006302 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1064551006303 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1064551006304 minor groove reading motif; other site 1064551006305 helix-hairpin-helix signature motif; other site 1064551006306 substrate binding pocket [chemical binding]; other site 1064551006307 active site 1064551006308 putative chaperone; Provisional; Region: PRK11678 1064551006309 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1064551006310 nucleotide binding site [chemical binding]; other site 1064551006311 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1064551006312 SBD interface [polypeptide binding]; other site 1064551006313 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 1064551006314 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1064551006315 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064551006316 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1064551006317 Protein export membrane protein; Region: SecD_SecF; cl14618 1064551006318 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1064551006319 putative transporter; Provisional; Region: PRK10504 1064551006320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551006321 putative substrate translocation pore; other site 1064551006322 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 1064551006323 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064551006324 dimerization interface [polypeptide binding]; other site 1064551006325 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064551006326 dimer interface [polypeptide binding]; other site 1064551006327 phosphorylation site [posttranslational modification] 1064551006328 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064551006329 ATP binding site [chemical binding]; other site 1064551006330 Mg2+ binding site [ion binding]; other site 1064551006331 G-X-G motif; other site 1064551006332 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 1064551006333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064551006334 active site 1064551006335 phosphorylation site [posttranslational modification] 1064551006336 intermolecular recognition site; other site 1064551006337 dimerization interface [polypeptide binding]; other site 1064551006338 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1064551006339 DNA binding site [nucleotide binding] 1064551006340 PcfJ-like protein; Region: PcfJ; pfam14284 1064551006341 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 1064551006342 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 1064551006343 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1064551006344 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1064551006345 RHS protein; Region: RHS; pfam03527 1064551006346 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1064551006347 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1064551006348 putative protease; Provisional; Region: PRK15452 1064551006349 Peptidase family U32; Region: Peptidase_U32; pfam01136 1064551006350 lipid kinase; Reviewed; Region: PRK13054 1064551006351 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1064551006352 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 1064551006353 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1064551006354 putative active site; other site 1064551006355 catalytic residue [active] 1064551006356 nucleoside transporter; Region: 2A0110; TIGR00889 1064551006357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551006358 putative substrate translocation pore; other site 1064551006359 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 1064551006360 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1064551006361 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1064551006362 substrate binding site [chemical binding]; other site 1064551006363 ATP binding site [chemical binding]; other site 1064551006364 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1064551006365 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064551006366 DNA-binding site [nucleotide binding]; DNA binding site 1064551006367 UTRA domain; Region: UTRA; pfam07702 1064551006368 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1064551006369 dimer interface [polypeptide binding]; other site 1064551006370 substrate binding site [chemical binding]; other site 1064551006371 ATP binding site [chemical binding]; other site 1064551006372 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1064551006373 substrate binding site [chemical binding]; other site 1064551006374 multimerization interface [polypeptide binding]; other site 1064551006375 ATP binding site [chemical binding]; other site 1064551006376 Predicted integral membrane protein [Function unknown]; Region: COG5455 1064551006377 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 1064551006378 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 1064551006379 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 1064551006380 PapC N-terminal domain; Region: PapC_N; pfam13954 1064551006381 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1064551006382 PapC C-terminal domain; Region: PapC_C; pfam13953 1064551006383 fimbrial chaperone protein PegB; Provisional; Region: PRK15218 1064551006384 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1064551006385 fimbrial chaperone protein; Provisional; Region: PRK15220 1064551006386 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 1064551006387 antiporter inner membrane protein; Provisional; Region: PRK11670 1064551006388 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1064551006389 Walker A motif; other site 1064551006390 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1064551006391 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1064551006392 active site 1064551006393 HIGH motif; other site 1064551006394 KMSKS motif; other site 1064551006395 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1064551006396 tRNA binding surface [nucleotide binding]; other site 1064551006397 anticodon binding site; other site 1064551006398 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1064551006399 dimer interface [polypeptide binding]; other site 1064551006400 putative tRNA-binding site [nucleotide binding]; other site 1064551006401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 1064551006402 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 1064551006403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 1064551006404 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1064551006405 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1064551006406 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 1064551006407 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064551006408 active site 1064551006409 phosphorylation site [posttranslational modification] 1064551006410 intermolecular recognition site; other site 1064551006411 dimerization interface [polypeptide binding]; other site 1064551006412 LytTr DNA-binding domain; Region: LytTR; pfam04397 1064551006413 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1064551006414 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1064551006415 GAF domain; Region: GAF; pfam01590 1064551006416 Histidine kinase; Region: His_kinase; pfam06580 1064551006417 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064551006418 ATP binding site [chemical binding]; other site 1064551006419 Mg2+ binding site [ion binding]; other site 1064551006420 G-X-G motif; other site 1064551006421 transcriptional regulator MirA; Provisional; Region: PRK15043 1064551006422 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 1064551006423 DNA binding residues [nucleotide binding] 1064551006424 hypothetical protein; Provisional; Region: PRK13681 1064551006425 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1064551006426 putative PBP binding loops; other site 1064551006427 ABC-ATPase subunit interface; other site 1064551006428 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1064551006429 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1064551006430 Walker A/P-loop; other site 1064551006431 ATP binding site [chemical binding]; other site 1064551006432 Q-loop/lid; other site 1064551006433 ABC transporter signature motif; other site 1064551006434 Walker B; other site 1064551006435 D-loop; other site 1064551006436 H-loop/switch region; other site 1064551006437 CBS domain; Region: CBS; pfam00571 1064551006438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551006439 dimer interface [polypeptide binding]; other site 1064551006440 conserved gate region; other site 1064551006441 ABC-ATPase subunit interface; other site 1064551006442 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1064551006443 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1064551006444 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1064551006445 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1064551006446 D-lactate dehydrogenase; Provisional; Region: PRK11183 1064551006447 FAD binding domain; Region: FAD_binding_4; pfam01565 1064551006448 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 1064551006449 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 1064551006450 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1064551006451 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 1064551006452 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1064551006453 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1064551006454 oxidoreductase; Provisional; Region: PRK12743 1064551006455 classical (c) SDRs; Region: SDR_c; cd05233 1064551006456 NAD(P) binding site [chemical binding]; other site 1064551006457 active site 1064551006458 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 1064551006459 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 1064551006460 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1064551006461 FMN binding site [chemical binding]; other site 1064551006462 active site 1064551006463 catalytic residues [active] 1064551006464 substrate binding site [chemical binding]; other site 1064551006465 salicylate hydroxylase; Provisional; Region: PRK08163 1064551006466 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1064551006467 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 1064551006468 maleylacetoacetate isomerase; Region: maiA; TIGR01262 1064551006469 C-terminal domain interface [polypeptide binding]; other site 1064551006470 GSH binding site (G-site) [chemical binding]; other site 1064551006471 putative dimer interface [polypeptide binding]; other site 1064551006472 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 1064551006473 dimer interface [polypeptide binding]; other site 1064551006474 N-terminal domain interface [polypeptide binding]; other site 1064551006475 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 1064551006476 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1064551006477 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1064551006478 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 1064551006479 Cupin domain; Region: Cupin_2; pfam07883 1064551006480 Cupin domain; Region: Cupin_2; pfam07883 1064551006481 benzoate transport; Region: 2A0115; TIGR00895 1064551006482 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551006483 putative substrate translocation pore; other site 1064551006484 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1064551006485 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551006486 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1064551006487 dimerization interface [polypeptide binding]; other site 1064551006488 hypothetical protein; Provisional; Region: PRK01821 1064551006489 hypothetical protein; Provisional; Region: PRK10711 1064551006490 cytidine deaminase; Provisional; Region: PRK09027 1064551006491 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1064551006492 active site 1064551006493 catalytic motif [active] 1064551006494 Zn binding site [ion binding]; other site 1064551006495 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1064551006496 active site 1064551006497 catalytic motif [active] 1064551006498 Zn binding site [ion binding]; other site 1064551006499 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1064551006500 putative active site [active] 1064551006501 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 1064551006502 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 1064551006503 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1064551006504 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1064551006505 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 1064551006506 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 1064551006507 homodimer interface [polypeptide binding]; other site 1064551006508 active site 1064551006509 FMN binding site [chemical binding]; other site 1064551006510 substrate binding site [chemical binding]; other site 1064551006511 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1064551006512 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1064551006513 TM-ABC transporter signature motif; other site 1064551006514 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1064551006515 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 1064551006516 Walker A/P-loop; other site 1064551006517 ATP binding site [chemical binding]; other site 1064551006518 Q-loop/lid; other site 1064551006519 ABC transporter signature motif; other site 1064551006520 Walker B; other site 1064551006521 D-loop; other site 1064551006522 H-loop/switch region; other site 1064551006523 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1064551006524 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 1064551006525 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 1064551006526 ligand binding site [chemical binding]; other site 1064551006527 calcium binding site [ion binding]; other site 1064551006528 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 1064551006529 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1064551006530 DNA binding site [nucleotide binding] 1064551006531 domain linker motif; other site 1064551006532 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1064551006533 dimerization interface (closed form) [polypeptide binding]; other site 1064551006534 ligand binding site [chemical binding]; other site 1064551006535 Predicted membrane protein [Function unknown]; Region: COG2311 1064551006536 hypothetical protein; Provisional; Region: PRK10835 1064551006537 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1064551006538 GTP cyclohydrolase I; Provisional; Region: PLN03044 1064551006539 active site 1064551006540 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064551006541 non-specific DNA binding site [nucleotide binding]; other site 1064551006542 salt bridge; other site 1064551006543 sequence-specific DNA binding site [nucleotide binding]; other site 1064551006544 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1064551006545 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1064551006546 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1064551006547 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1064551006548 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1064551006549 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064551006550 motif II; other site 1064551006551 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1064551006552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551006553 putative substrate translocation pore; other site 1064551006554 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 1064551006555 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1064551006556 N-terminal plug; other site 1064551006557 ligand-binding site [chemical binding]; other site 1064551006558 lysine transporter; Provisional; Region: PRK10836 1064551006559 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1064551006560 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551006561 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1064551006562 putative dimerization interface [polypeptide binding]; other site 1064551006563 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1064551006564 endonuclease IV; Provisional; Region: PRK01060 1064551006565 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1064551006566 AP (apurinic/apyrimidinic) site pocket; other site 1064551006567 DNA interaction; other site 1064551006568 Metal-binding active site; metal-binding site 1064551006569 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 1064551006570 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 1064551006571 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1064551006572 active site 1064551006573 P-loop; other site 1064551006574 phosphorylation site [posttranslational modification] 1064551006575 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 1064551006576 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1064551006577 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1064551006578 putative substrate binding site [chemical binding]; other site 1064551006579 putative ATP binding site [chemical binding]; other site 1064551006580 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 1064551006581 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1064551006582 active site 1064551006583 phosphorylation site [posttranslational modification] 1064551006584 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1064551006585 dimerization domain swap beta strand [polypeptide binding]; other site 1064551006586 regulatory protein interface [polypeptide binding]; other site 1064551006587 active site 1064551006588 regulatory phosphorylation site [posttranslational modification]; other site 1064551006589 sugar efflux transporter B; Provisional; Region: PRK15011 1064551006590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551006591 putative substrate translocation pore; other site 1064551006592 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1064551006593 elongation factor P; Provisional; Region: PRK04542 1064551006594 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1064551006595 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1064551006596 RNA binding site [nucleotide binding]; other site 1064551006597 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1064551006598 RNA binding site [nucleotide binding]; other site 1064551006599 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1064551006600 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1064551006601 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1064551006602 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1064551006603 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1064551006604 active site 1064551006605 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 1064551006606 NlpC/P60 family; Region: NLPC_P60; pfam00877 1064551006607 phage resistance protein; Provisional; Region: PRK10551 1064551006608 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1064551006609 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1064551006610 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1064551006611 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1064551006612 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1064551006613 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551006614 dimer interface [polypeptide binding]; other site 1064551006615 conserved gate region; other site 1064551006616 putative PBP binding loops; other site 1064551006617 ABC-ATPase subunit interface; other site 1064551006618 microcin C ABC transporter permease; Provisional; Region: PRK15021 1064551006619 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551006620 dimer interface [polypeptide binding]; other site 1064551006621 conserved gate region; other site 1064551006622 ABC-ATPase subunit interface; other site 1064551006623 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 1064551006624 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1064551006625 Walker A/P-loop; other site 1064551006626 ATP binding site [chemical binding]; other site 1064551006627 Q-loop/lid; other site 1064551006628 ABC transporter signature motif; other site 1064551006629 Walker B; other site 1064551006630 D-loop; other site 1064551006631 H-loop/switch region; other site 1064551006632 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1064551006633 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1064551006634 Walker A/P-loop; other site 1064551006635 ATP binding site [chemical binding]; other site 1064551006636 Q-loop/lid; other site 1064551006637 ABC transporter signature motif; other site 1064551006638 Walker B; other site 1064551006639 D-loop; other site 1064551006640 H-loop/switch region; other site 1064551006641 hypothetical protein; Provisional; Region: PRK11835 1064551006642 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551006643 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1064551006644 putative substrate translocation pore; other site 1064551006645 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 1064551006646 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1064551006647 RNA binding surface [nucleotide binding]; other site 1064551006648 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1064551006649 active site 1064551006650 uracil binding [chemical binding]; other site 1064551006651 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1064551006652 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1064551006653 ATP binding site [chemical binding]; other site 1064551006654 putative Mg++ binding site [ion binding]; other site 1064551006655 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1064551006656 nucleotide binding region [chemical binding]; other site 1064551006657 ATP-binding site [chemical binding]; other site 1064551006658 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 1064551006659 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1064551006660 5S rRNA interface [nucleotide binding]; other site 1064551006661 CTC domain interface [polypeptide binding]; other site 1064551006662 L16 interface [polypeptide binding]; other site 1064551006663 Nucleoid-associated protein [General function prediction only]; Region: COG3081 1064551006664 nucleoid-associated protein NdpA; Validated; Region: PRK00378 1064551006665 hypothetical protein; Provisional; Region: PRK13689 1064551006666 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 1064551006667 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 1064551006668 Sulfatase; Region: Sulfatase; cl17466 1064551006669 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1064551006670 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 1064551006671 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1064551006672 DinI-like family; Region: DinI; cl11630 1064551006673 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 1064551006674 transcriptional regulator NarP; Provisional; Region: PRK10403 1064551006675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064551006676 active site 1064551006677 phosphorylation site [posttranslational modification] 1064551006678 intermolecular recognition site; other site 1064551006679 dimerization interface [polypeptide binding]; other site 1064551006680 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064551006681 DNA binding residues [nucleotide binding] 1064551006682 dimerization interface [polypeptide binding]; other site 1064551006683 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 1064551006684 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 1064551006685 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 1064551006686 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1064551006687 catalytic residues [active] 1064551006688 central insert; other site 1064551006689 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 1064551006690 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150 1064551006691 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 1064551006692 heme exporter protein CcmC; Region: ccmC; TIGR01191 1064551006693 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386 1064551006694 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 1064551006695 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064551006696 Walker A/P-loop; other site 1064551006697 ATP binding site [chemical binding]; other site 1064551006698 Q-loop/lid; other site 1064551006699 ABC transporter signature motif; other site 1064551006700 Walker B; other site 1064551006701 D-loop; other site 1064551006702 H-loop/switch region; other site 1064551006703 cytochrome c-type protein NapC; Provisional; Region: PRK10617 1064551006704 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 1064551006705 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 1064551006706 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 1064551006707 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1064551006708 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1064551006709 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 1064551006710 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 1064551006711 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1064551006712 [4Fe-4S] binding site [ion binding]; other site 1064551006713 molybdopterin cofactor binding site; other site 1064551006714 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1064551006715 molybdopterin cofactor binding site; other site 1064551006716 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 1064551006717 ferredoxin-type protein; Provisional; Region: PRK10194 1064551006718 4Fe-4S binding domain; Region: Fer4; cl02805 1064551006719 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 1064551006720 secondary substrate binding site; other site 1064551006721 primary substrate binding site; other site 1064551006722 inhibition loop; other site 1064551006723 dimerization interface [polypeptide binding]; other site 1064551006724 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 1064551006725 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1064551006726 Walker A/P-loop; other site 1064551006727 ATP binding site [chemical binding]; other site 1064551006728 Q-loop/lid; other site 1064551006729 ABC transporter signature motif; other site 1064551006730 Walker B; other site 1064551006731 D-loop; other site 1064551006732 H-loop/switch region; other site 1064551006733 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 1064551006734 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 1064551006735 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1064551006736 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064551006737 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1064551006738 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1064551006739 DNA binding site [nucleotide binding] 1064551006740 active site 1064551006741 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 1064551006742 ApbE family; Region: ApbE; pfam02424 1064551006743 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1064551006744 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1064551006745 trimer interface [polypeptide binding]; other site 1064551006746 eyelet of channel; other site 1064551006747 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 1064551006748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064551006749 ATP binding site [chemical binding]; other site 1064551006750 G-X-G motif; other site 1064551006751 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1064551006752 putative binding surface; other site 1064551006753 active site 1064551006754 transcriptional regulator RcsB; Provisional; Region: PRK10840 1064551006755 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064551006756 active site 1064551006757 phosphorylation site [posttranslational modification] 1064551006758 intermolecular recognition site; other site 1064551006759 dimerization interface [polypeptide binding]; other site 1064551006760 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064551006761 DNA binding residues [nucleotide binding] 1064551006762 dimerization interface [polypeptide binding]; other site 1064551006763 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 1064551006764 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064551006765 dimer interface [polypeptide binding]; other site 1064551006766 phosphorylation site [posttranslational modification] 1064551006767 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064551006768 ATP binding site [chemical binding]; other site 1064551006769 Mg2+ binding site [ion binding]; other site 1064551006770 G-X-G motif; other site 1064551006771 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 1064551006772 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064551006773 active site 1064551006774 phosphorylation site [posttranslational modification] 1064551006775 intermolecular recognition site; other site 1064551006776 dimerization interface [polypeptide binding]; other site 1064551006777 DNA gyrase subunit A; Validated; Region: PRK05560 1064551006778 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1064551006779 CAP-like domain; other site 1064551006780 active site 1064551006781 primary dimer interface [polypeptide binding]; other site 1064551006782 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1064551006783 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1064551006784 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1064551006785 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1064551006786 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1064551006787 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1064551006788 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1064551006789 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1064551006790 active site pocket [active] 1064551006791 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1064551006792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551006793 putative substrate translocation pore; other site 1064551006794 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1064551006795 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064551006796 DNA-binding site [nucleotide binding]; DNA binding site 1064551006797 FCD domain; Region: FCD; pfam07729 1064551006798 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1064551006799 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064551006800 S-adenosylmethionine binding site [chemical binding]; other site 1064551006801 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 1064551006802 ATP cone domain; Region: ATP-cone; pfam03477 1064551006803 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1064551006804 active site 1064551006805 dimer interface [polypeptide binding]; other site 1064551006806 catalytic residues [active] 1064551006807 effector binding site; other site 1064551006808 R2 peptide binding site; other site 1064551006809 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1064551006810 dimer interface [polypeptide binding]; other site 1064551006811 putative radical transfer pathway; other site 1064551006812 diiron center [ion binding]; other site 1064551006813 tyrosyl radical; other site 1064551006814 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1064551006815 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1064551006816 catalytic loop [active] 1064551006817 iron binding site [ion binding]; other site 1064551006818 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1064551006819 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551006820 putative substrate translocation pore; other site 1064551006821 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1064551006822 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551006823 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1064551006824 dimerization interface [polypeptide binding]; other site 1064551006825 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 1064551006826 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 1064551006827 active site 1064551006828 catalytic site [active] 1064551006829 metal binding site [ion binding]; metal-binding site 1064551006830 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1064551006831 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551006832 putative substrate translocation pore; other site 1064551006833 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 1064551006834 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1064551006835 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1064551006836 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 1064551006837 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 1064551006838 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 1064551006839 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1064551006840 Cysteine-rich domain; Region: CCG; pfam02754 1064551006841 Cysteine-rich domain; Region: CCG; pfam02754 1064551006842 deubiquitinase SseL; Provisional; Region: PRK14848 1064551006843 hypothetical protein; Provisional; Region: PRK03673 1064551006844 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 1064551006845 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551006846 D-galactonate transporter; Region: 2A0114; TIGR00893 1064551006847 putative substrate translocation pore; other site 1064551006848 L-rhamnonate dehydratase; Provisional; Region: PRK15440 1064551006849 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 1064551006850 putative active site pocket [active] 1064551006851 putative metal binding site [ion binding]; other site 1064551006852 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1064551006853 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1064551006854 Bacterial transcriptional regulator; Region: IclR; pfam01614 1064551006855 hypothetical protein; Provisional; Region: PRK03673 1064551006856 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1064551006857 putative MPT binding site; other site 1064551006858 Competence-damaged protein; Region: CinA; cl00666 1064551006859 YfaZ precursor; Region: YfaZ; pfam07437 1064551006860 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 1064551006861 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 1064551006862 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1064551006863 catalytic core [active] 1064551006864 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1064551006865 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1064551006866 inhibitor-cofactor binding pocket; inhibition site 1064551006867 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551006868 catalytic residue [active] 1064551006869 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1064551006870 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1064551006871 Ligand binding site; other site 1064551006872 Putative Catalytic site; other site 1064551006873 DXD motif; other site 1064551006874 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 1064551006875 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1064551006876 active site 1064551006877 substrate binding site [chemical binding]; other site 1064551006878 cosubstrate binding site; other site 1064551006879 catalytic site [active] 1064551006880 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 1064551006881 active site 1064551006882 hexamer interface [polypeptide binding]; other site 1064551006883 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 1064551006884 NAD binding site [chemical binding]; other site 1064551006885 substrate binding site [chemical binding]; other site 1064551006886 active site 1064551006887 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 1064551006888 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 1064551006889 putative active site [active] 1064551006890 putative catalytic site [active] 1064551006891 putative Zn binding site [ion binding]; other site 1064551006892 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 1064551006893 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1064551006894 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 1064551006895 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 1064551006896 signal transduction protein PmrD; Provisional; Region: PRK15450 1064551006897 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 1064551006898 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1064551006899 acyl-activating enzyme (AAE) consensus motif; other site 1064551006900 putative AMP binding site [chemical binding]; other site 1064551006901 putative active site [active] 1064551006902 putative CoA binding site [chemical binding]; other site 1064551006903 O-succinylbenzoate synthase; Provisional; Region: PRK05105 1064551006904 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1064551006905 active site 1064551006906 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1064551006907 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1064551006908 substrate binding site [chemical binding]; other site 1064551006909 oxyanion hole (OAH) forming residues; other site 1064551006910 trimer interface [polypeptide binding]; other site 1064551006911 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 1064551006912 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1064551006913 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1064551006914 dimer interface [polypeptide binding]; other site 1064551006915 tetramer interface [polypeptide binding]; other site 1064551006916 PYR/PP interface [polypeptide binding]; other site 1064551006917 TPP binding site [chemical binding]; other site 1064551006918 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1064551006919 TPP-binding site; other site 1064551006920 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 1064551006921 isochorismate synthases; Region: isochor_syn; TIGR00543 1064551006922 hypothetical protein; Provisional; Region: PRK10404 1064551006923 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064551006924 Coenzyme A binding pocket [chemical binding]; other site 1064551006925 ribonuclease BN; Region: true_RNase_BN; TIGR02649 1064551006926 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1064551006927 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1064551006928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064551006929 active site 1064551006930 phosphorylation site [posttranslational modification] 1064551006931 intermolecular recognition site; other site 1064551006932 dimerization interface [polypeptide binding]; other site 1064551006933 von Willebrand factor; Region: vWF_A; pfam12450 1064551006934 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1064551006935 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 1064551006936 metal ion-dependent adhesion site (MIDAS); other site 1064551006937 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 1064551006938 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1064551006939 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1064551006940 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1064551006941 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1064551006942 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1064551006943 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1064551006944 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1064551006945 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1064551006946 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1064551006947 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1064551006948 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1064551006949 4Fe-4S binding domain; Region: Fer4; pfam00037 1064551006950 4Fe-4S binding domain; Region: Fer4; pfam00037 1064551006951 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1064551006952 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 1064551006953 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1064551006954 catalytic loop [active] 1064551006955 iron binding site [ion binding]; other site 1064551006956 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1064551006957 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1064551006958 [4Fe-4S] binding site [ion binding]; other site 1064551006959 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1064551006960 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 1064551006961 SLBB domain; Region: SLBB; pfam10531 1064551006962 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1064551006963 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1064551006964 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1064551006965 putative dimer interface [polypeptide binding]; other site 1064551006966 [2Fe-2S] cluster binding site [ion binding]; other site 1064551006967 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 1064551006968 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1064551006969 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1064551006970 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 1064551006971 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1064551006972 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 1064551006973 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551006974 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 1064551006975 putative dimerization interface [polypeptide binding]; other site 1064551006976 aminotransferase AlaT; Validated; Region: PRK09265 1064551006977 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1064551006978 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551006979 homodimer interface [polypeptide binding]; other site 1064551006980 catalytic residue [active] 1064551006981 5'-nucleotidase; Provisional; Region: PRK03826 1064551006982 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1064551006983 transmembrane helices; other site 1064551006984 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1064551006985 TrkA-C domain; Region: TrkA_C; pfam02080 1064551006986 TrkA-C domain; Region: TrkA_C; pfam02080 1064551006987 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1064551006988 putative phosphatase; Provisional; Region: PRK11587 1064551006989 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064551006990 motif II; other site 1064551006991 hypothetical protein; Validated; Region: PRK05445 1064551006992 hypothetical protein; Provisional; Region: PRK01816 1064551006993 propionate/acetate kinase; Provisional; Region: PRK12379 1064551006994 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1064551006995 phosphate acetyltransferase; Reviewed; Region: PRK05632 1064551006996 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1064551006997 DRTGG domain; Region: DRTGG; pfam07085 1064551006998 phosphate acetyltransferase; Region: pta; TIGR00651 1064551006999 hypothetical protein; Provisional; Region: PRK11588 1064551007000 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1064551007001 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1064551007002 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1064551007003 PYR/PP interface [polypeptide binding]; other site 1064551007004 dimer interface [polypeptide binding]; other site 1064551007005 TPP binding site [chemical binding]; other site 1064551007006 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1064551007007 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1064551007008 TPP-binding site [chemical binding]; other site 1064551007009 dimer interface [polypeptide binding]; other site 1064551007010 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK12996 1064551007011 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1064551007012 active site 1064551007013 P-loop; other site 1064551007014 phosphorylation site [posttranslational modification] 1064551007015 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1064551007016 active site 1064551007017 phosphorylation site [posttranslational modification] 1064551007018 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1064551007019 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1064551007020 DNA binding site [nucleotide binding] 1064551007021 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1064551007022 putative dimerization interface [polypeptide binding]; other site 1064551007023 putative ligand binding site [chemical binding]; other site 1064551007024 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 1064551007025 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 1064551007026 nudix motif; other site 1064551007027 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1064551007028 active site 1064551007029 metal binding site [ion binding]; metal-binding site 1064551007030 homotetramer interface [polypeptide binding]; other site 1064551007031 glutathione S-transferase; Provisional; Region: PRK15113 1064551007032 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1064551007033 C-terminal domain interface [polypeptide binding]; other site 1064551007034 GSH binding site (G-site) [chemical binding]; other site 1064551007035 dimer interface [polypeptide binding]; other site 1064551007036 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 1064551007037 N-terminal domain interface [polypeptide binding]; other site 1064551007038 putative dimer interface [polypeptide binding]; other site 1064551007039 putative substrate binding pocket (H-site) [chemical binding]; other site 1064551007040 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1064551007041 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1064551007042 C-terminal domain interface [polypeptide binding]; other site 1064551007043 GSH binding site (G-site) [chemical binding]; other site 1064551007044 dimer interface [polypeptide binding]; other site 1064551007045 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1064551007046 N-terminal domain interface [polypeptide binding]; other site 1064551007047 putative dimer interface [polypeptide binding]; other site 1064551007048 active site 1064551007049 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1064551007050 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1064551007051 putative NAD(P) binding site [chemical binding]; other site 1064551007052 putative active site [active] 1064551007053 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 1064551007054 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1064551007055 Walker A/P-loop; other site 1064551007056 ATP binding site [chemical binding]; other site 1064551007057 Q-loop/lid; other site 1064551007058 ABC transporter signature motif; other site 1064551007059 Walker B; other site 1064551007060 D-loop; other site 1064551007061 H-loop/switch region; other site 1064551007062 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1064551007063 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551007064 dimer interface [polypeptide binding]; other site 1064551007065 conserved gate region; other site 1064551007066 putative PBP binding loops; other site 1064551007067 ABC-ATPase subunit interface; other site 1064551007068 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1064551007069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551007070 dimer interface [polypeptide binding]; other site 1064551007071 conserved gate region; other site 1064551007072 putative PBP binding loops; other site 1064551007073 ABC-ATPase subunit interface; other site 1064551007074 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 1064551007075 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064551007076 substrate binding pocket [chemical binding]; other site 1064551007077 membrane-bound complex binding site; other site 1064551007078 hinge residues; other site 1064551007079 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 1064551007080 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064551007081 substrate binding pocket [chemical binding]; other site 1064551007082 membrane-bound complex binding site; other site 1064551007083 hinge residues; other site 1064551007084 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 1064551007085 Flavoprotein; Region: Flavoprotein; pfam02441 1064551007086 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1064551007087 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 1064551007088 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 1064551007089 dimer interface [polypeptide binding]; other site 1064551007090 active site 1064551007091 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1064551007092 substrate binding site [chemical binding]; other site 1064551007093 catalytic residue [active] 1064551007094 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 1064551007095 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1064551007096 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1064551007097 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1064551007098 catalytic residue [active] 1064551007099 PAS fold; Region: PAS_4; pfam08448 1064551007100 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1064551007101 putative active site [active] 1064551007102 heme pocket [chemical binding]; other site 1064551007103 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1064551007104 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064551007105 Walker A motif; other site 1064551007106 ATP binding site [chemical binding]; other site 1064551007107 Walker B motif; other site 1064551007108 arginine finger; other site 1064551007109 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1064551007110 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1064551007111 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1064551007112 active site 1064551007113 tetramer interface [polypeptide binding]; other site 1064551007114 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1064551007115 active site 1064551007116 colicin V production protein; Provisional; Region: PRK10845 1064551007117 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1064551007118 cell division protein DedD; Provisional; Region: PRK11633 1064551007119 Sporulation related domain; Region: SPOR; pfam05036 1064551007120 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 1064551007121 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1064551007122 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1064551007123 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1064551007124 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1064551007125 hypothetical protein; Provisional; Region: PRK10847 1064551007126 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1064551007127 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 1064551007128 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1064551007129 dimerization interface 3.5A [polypeptide binding]; other site 1064551007130 active site 1064551007131 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 1064551007132 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1064551007133 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 1064551007134 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 1064551007135 ligand binding site [chemical binding]; other site 1064551007136 NAD binding site [chemical binding]; other site 1064551007137 catalytic site [active] 1064551007138 homodimer interface [polypeptide binding]; other site 1064551007139 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 1064551007140 putative transporter; Provisional; Region: PRK12382 1064551007141 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551007142 putative substrate translocation pore; other site 1064551007143 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064551007144 non-specific DNA binding site [nucleotide binding]; other site 1064551007145 salt bridge; other site 1064551007146 sequence-specific DNA binding site [nucleotide binding]; other site 1064551007147 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 1064551007148 CAAX protease self-immunity; Region: Abi; pfam02517 1064551007149 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1064551007150 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1064551007151 dimer interface [polypeptide binding]; other site 1064551007152 active site 1064551007153 Uncharacterized conserved protein [Function unknown]; Region: COG4121 1064551007154 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 1064551007155 YfcL protein; Region: YfcL; pfam08891 1064551007156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 1064551007157 hypothetical protein; Provisional; Region: PRK10621 1064551007158 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1064551007159 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 1064551007160 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 1064551007161 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1064551007162 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1064551007163 Tetramer interface [polypeptide binding]; other site 1064551007164 active site 1064551007165 FMN-binding site [chemical binding]; other site 1064551007166 HemK family putative methylases; Region: hemK_fam; TIGR00536 1064551007167 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064551007168 S-adenosylmethionine binding site [chemical binding]; other site 1064551007169 hypothetical protein; Provisional; Region: PRK04946 1064551007170 Smr domain; Region: Smr; pfam01713 1064551007171 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1064551007172 catalytic core [active] 1064551007173 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1064551007174 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1064551007175 substrate binding site [chemical binding]; other site 1064551007176 oxyanion hole (OAH) forming residues; other site 1064551007177 trimer interface [polypeptide binding]; other site 1064551007178 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1064551007179 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1064551007180 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 1064551007181 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1064551007182 dimer interface [polypeptide binding]; other site 1064551007183 active site 1064551007184 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 1064551007185 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 1064551007186 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 1064551007187 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1064551007188 outer membrane protease; Reviewed; Region: PRK10993 1064551007189 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1064551007190 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064551007191 active site 1064551007192 phosphorylation site [posttranslational modification] 1064551007193 intermolecular recognition site; other site 1064551007194 dimerization interface [polypeptide binding]; other site 1064551007195 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1064551007196 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1064551007197 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 1064551007198 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1064551007199 dimerization interface [polypeptide binding]; other site 1064551007200 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064551007201 dimer interface [polypeptide binding]; other site 1064551007202 phosphorylation site [posttranslational modification] 1064551007203 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064551007204 ATP binding site [chemical binding]; other site 1064551007205 Mg2+ binding site [ion binding]; other site 1064551007206 G-X-G motif; other site 1064551007207 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1064551007208 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1064551007209 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 1064551007210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551007211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551007212 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 1064551007213 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1064551007214 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1064551007215 putative acyl-acceptor binding pocket; other site 1064551007216 aminotransferase; Validated; Region: PRK08175 1064551007217 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1064551007218 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551007219 homodimer interface [polypeptide binding]; other site 1064551007220 catalytic residue [active] 1064551007221 glucokinase; Provisional; Region: glk; PRK00292 1064551007222 glucokinase, proteobacterial type; Region: glk; TIGR00749 1064551007223 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1064551007224 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1064551007225 Cl- selectivity filter; other site 1064551007226 Cl- binding residues [ion binding]; other site 1064551007227 pore gating glutamate residue; other site 1064551007228 dimer interface [polypeptide binding]; other site 1064551007229 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 1064551007230 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1064551007231 dimer interface [polypeptide binding]; other site 1064551007232 PYR/PP interface [polypeptide binding]; other site 1064551007233 TPP binding site [chemical binding]; other site 1064551007234 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1064551007235 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1064551007236 TPP-binding site [chemical binding]; other site 1064551007237 dimer interface [polypeptide binding]; other site 1064551007238 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1064551007239 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1064551007240 active site 1064551007241 catalytic tetrad [active] 1064551007242 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 1064551007243 manganese transport protein MntH; Reviewed; Region: PRK00701 1064551007244 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1064551007245 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1064551007246 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1064551007247 Nucleoside recognition; Region: Gate; pfam07670 1064551007248 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1064551007249 MASE1; Region: MASE1; pfam05231 1064551007250 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1064551007251 diguanylate cyclase; Region: GGDEF; smart00267 1064551007252 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1064551007253 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 1064551007254 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 1064551007255 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1064551007256 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1064551007257 active site 1064551007258 HIGH motif; other site 1064551007259 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1064551007260 active site 1064551007261 KMSKS motif; other site 1064551007262 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1064551007263 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551007264 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 1064551007265 putative dimerization interface [polypeptide binding]; other site 1064551007266 putative substrate binding pocket [chemical binding]; other site 1064551007267 XapX domain; Region: XapX; TIGR03510 1064551007268 nucleoside transporter; Region: 2A0110; TIGR00889 1064551007269 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551007270 putative substrate translocation pore; other site 1064551007271 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1064551007272 hypothetical protein; Provisional; Region: PRK11528 1064551007273 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064551007274 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551007275 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1064551007276 putative dimerization interface [polypeptide binding]; other site 1064551007277 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1064551007278 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1064551007279 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 1064551007280 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1064551007281 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1064551007282 nucleotide binding pocket [chemical binding]; other site 1064551007283 K-X-D-G motif; other site 1064551007284 catalytic site [active] 1064551007285 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1064551007286 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1064551007287 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1064551007288 Dimer interface [polypeptide binding]; other site 1064551007289 BRCT sequence motif; other site 1064551007290 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 1064551007291 cell division protein ZipA; Provisional; Region: PRK03427 1064551007292 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 1064551007293 FtsZ protein binding site [polypeptide binding]; other site 1064551007294 putative sulfate transport protein CysZ; Validated; Region: PRK04949 1064551007295 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1064551007296 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1064551007297 dimer interface [polypeptide binding]; other site 1064551007298 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551007299 catalytic residue [active] 1064551007300 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1064551007301 dimerization domain swap beta strand [polypeptide binding]; other site 1064551007302 regulatory protein interface [polypeptide binding]; other site 1064551007303 active site 1064551007304 regulatory phosphorylation site [posttranslational modification]; other site 1064551007305 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 1064551007306 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1064551007307 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1064551007308 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1064551007309 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1064551007310 HPr interaction site; other site 1064551007311 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1064551007312 active site 1064551007313 phosphorylation site [posttranslational modification] 1064551007314 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1064551007315 dimer interface [polypeptide binding]; other site 1064551007316 pyridoxamine kinase; Validated; Region: PRK05756 1064551007317 pyridoxal binding site [chemical binding]; other site 1064551007318 ATP binding site [chemical binding]; other site 1064551007319 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 1064551007320 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064551007321 DNA-binding site [nucleotide binding]; DNA binding site 1064551007322 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1064551007323 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551007324 homodimer interface [polypeptide binding]; other site 1064551007325 catalytic residue [active] 1064551007326 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1064551007327 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1064551007328 catalytic triad [active] 1064551007329 hypothetical protein; Provisional; Region: PRK10318 1064551007330 Transglycosylase; Region: Transgly; cl17702 1064551007331 cysteine synthase B; Region: cysM; TIGR01138 1064551007332 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1064551007333 dimer interface [polypeptide binding]; other site 1064551007334 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551007335 catalytic residue [active] 1064551007336 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 1064551007337 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1064551007338 Walker A/P-loop; other site 1064551007339 ATP binding site [chemical binding]; other site 1064551007340 Q-loop/lid; other site 1064551007341 ABC transporter signature motif; other site 1064551007342 Walker B; other site 1064551007343 D-loop; other site 1064551007344 H-loop/switch region; other site 1064551007345 TOBE-like domain; Region: TOBE_3; pfam12857 1064551007346 sulfate transport protein; Provisional; Region: cysT; CHL00187 1064551007347 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551007348 dimer interface [polypeptide binding]; other site 1064551007349 conserved gate region; other site 1064551007350 putative PBP binding loops; other site 1064551007351 ABC-ATPase subunit interface; other site 1064551007352 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1064551007353 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551007354 dimer interface [polypeptide binding]; other site 1064551007355 conserved gate region; other site 1064551007356 putative PBP binding loops; other site 1064551007357 ABC-ATPase subunit interface; other site 1064551007358 thiosulfate transporter subunit; Provisional; Region: PRK10852 1064551007359 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1064551007360 short chain dehydrogenase; Provisional; Region: PRK08226 1064551007361 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 1064551007362 NAD binding site [chemical binding]; other site 1064551007363 homotetramer interface [polypeptide binding]; other site 1064551007364 homodimer interface [polypeptide binding]; other site 1064551007365 active site 1064551007366 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1064551007367 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 1064551007368 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 1064551007369 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 1064551007370 putative acetyltransferase; Provisional; Region: PRK03624 1064551007371 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064551007372 Coenzyme A binding pocket [chemical binding]; other site 1064551007373 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 1064551007374 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1064551007375 active site 1064551007376 metal binding site [ion binding]; metal-binding site 1064551007377 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1064551007378 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1064551007379 transcriptional regulator EutR; Provisional; Region: PRK10130 1064551007380 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064551007381 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064551007382 carboxysome structural protein EutK; Provisional; Region: PRK15466 1064551007383 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1064551007384 Hexamer interface [polypeptide binding]; other site 1064551007385 Hexagonal pore residue; other site 1064551007386 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 1064551007387 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 1064551007388 putative hexamer interface [polypeptide binding]; other site 1064551007389 putative hexagonal pore; other site 1064551007390 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 1064551007391 putative hexamer interface [polypeptide binding]; other site 1064551007392 putative hexagonal pore; other site 1064551007393 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 1064551007394 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 1064551007395 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1064551007396 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 1064551007397 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 1064551007398 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 1064551007399 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 1064551007400 active site 1064551007401 metal binding site [ion binding]; metal-binding site 1064551007402 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 1064551007403 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1064551007404 nucleotide binding site [chemical binding]; other site 1064551007405 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 1064551007406 putative catalytic cysteine [active] 1064551007407 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1064551007408 Hexamer/Pentamer interface [polypeptide binding]; other site 1064551007409 central pore; other site 1064551007410 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1064551007411 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 1064551007412 Hexamer interface [polypeptide binding]; other site 1064551007413 Putative hexagonal pore residue; other site 1064551007414 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1064551007415 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 1064551007416 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 1064551007417 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 1064551007418 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1064551007419 G1 box; other site 1064551007420 GTP/Mg2+ binding site [chemical binding]; other site 1064551007421 G2 box; other site 1064551007422 Switch I region; other site 1064551007423 G3 box; other site 1064551007424 Switch II region; other site 1064551007425 G4 box; other site 1064551007426 G5 box; other site 1064551007427 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 1064551007428 putative hexamer interface [polypeptide binding]; other site 1064551007429 putative hexagonal pore; other site 1064551007430 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1064551007431 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1064551007432 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1064551007433 putative NAD(P) binding site [chemical binding]; other site 1064551007434 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1064551007435 transaldolase-like protein; Provisional; Region: PTZ00411 1064551007436 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1064551007437 active site 1064551007438 dimer interface [polypeptide binding]; other site 1064551007439 catalytic residue [active] 1064551007440 transketolase; Reviewed; Region: PRK12753 1064551007441 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1064551007442 TPP-binding site [chemical binding]; other site 1064551007443 dimer interface [polypeptide binding]; other site 1064551007444 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1064551007445 PYR/PP interface [polypeptide binding]; other site 1064551007446 dimer interface [polypeptide binding]; other site 1064551007447 TPP binding site [chemical binding]; other site 1064551007448 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1064551007449 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 1064551007450 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1064551007451 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1064551007452 dimer interface [polypeptide binding]; other site 1064551007453 ADP-ribose binding site [chemical binding]; other site 1064551007454 active site 1064551007455 nudix motif; other site 1064551007456 metal binding site [ion binding]; metal-binding site 1064551007457 putative periplasmic esterase; Provisional; Region: PRK03642 1064551007458 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1064551007459 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 1064551007460 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1064551007461 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064551007462 dimerization interface [polypeptide binding]; other site 1064551007463 Histidine kinase; Region: HisKA_3; pfam07730 1064551007464 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064551007465 ATP binding site [chemical binding]; other site 1064551007466 Mg2+ binding site [ion binding]; other site 1064551007467 G-X-G motif; other site 1064551007468 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 1064551007469 Protein export membrane protein; Region: SecD_SecF; cl14618 1064551007470 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1064551007471 ArsC family; Region: ArsC; pfam03960 1064551007472 putative catalytic residues [active] 1064551007473 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1064551007474 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1064551007475 metal binding site [ion binding]; metal-binding site 1064551007476 dimer interface [polypeptide binding]; other site 1064551007477 hypothetical protein; Provisional; Region: PRK13664 1064551007478 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 1064551007479 Helicase; Region: Helicase_RecD; pfam05127 1064551007480 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1064551007481 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 1064551007482 Predicted metalloprotease [General function prediction only]; Region: COG2321 1064551007483 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1064551007484 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1064551007485 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1064551007486 ATP binding site [chemical binding]; other site 1064551007487 active site 1064551007488 substrate binding site [chemical binding]; other site 1064551007489 lipoprotein; Provisional; Region: PRK11679 1064551007490 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 1064551007491 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1064551007492 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1064551007493 dimer interface [polypeptide binding]; other site 1064551007494 active site 1064551007495 catalytic residue [active] 1064551007496 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 1064551007497 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 1064551007498 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1064551007499 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1064551007500 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1064551007501 catalytic triad [active] 1064551007502 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1064551007503 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1064551007504 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1064551007505 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1064551007506 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1064551007507 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1064551007508 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1064551007509 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1064551007510 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1064551007511 Peptidase family M48; Region: Peptidase_M48; cl12018 1064551007512 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1064551007513 ArsC family; Region: ArsC; pfam03960 1064551007514 catalytic residues [active] 1064551007515 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1064551007516 DNA replication initiation factor; Provisional; Region: PRK08084 1064551007517 uracil transporter; Provisional; Region: PRK10720 1064551007518 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1064551007519 active site 1064551007520 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1064551007521 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1064551007522 dimerization interface [polypeptide binding]; other site 1064551007523 putative ATP binding site [chemical binding]; other site 1064551007524 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1064551007525 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1064551007526 active site 1064551007527 substrate binding site [chemical binding]; other site 1064551007528 cosubstrate binding site; other site 1064551007529 catalytic site [active] 1064551007530 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 1064551007531 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1064551007532 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1064551007533 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1064551007534 putative active site [active] 1064551007535 catalytic site [active] 1064551007536 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 1064551007537 domain interface [polypeptide binding]; other site 1064551007538 active site 1064551007539 catalytic site [active] 1064551007540 exopolyphosphatase; Provisional; Region: PRK10854 1064551007541 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1064551007542 nucleotide binding site [chemical binding]; other site 1064551007543 MASE1; Region: MASE1; pfam05231 1064551007544 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1064551007545 diguanylate cyclase; Region: GGDEF; smart00267 1064551007546 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1064551007547 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 1064551007548 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1064551007549 Integrase core domain; Region: rve; pfam00665 1064551007550 GMP synthase; Reviewed; Region: guaA; PRK00074 1064551007551 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1064551007552 AMP/PPi binding site [chemical binding]; other site 1064551007553 candidate oxyanion hole; other site 1064551007554 catalytic triad [active] 1064551007555 potential glutamine specificity residues [chemical binding]; other site 1064551007556 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1064551007557 ATP Binding subdomain [chemical binding]; other site 1064551007558 Ligand Binding sites [chemical binding]; other site 1064551007559 Dimerization subdomain; other site 1064551007560 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1064551007561 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1064551007562 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1064551007563 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1064551007564 active site 1064551007565 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1064551007566 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1064551007567 generic binding surface II; other site 1064551007568 generic binding surface I; other site 1064551007569 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 1064551007570 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1064551007571 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1064551007572 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1064551007573 Autotransporter beta-domain; Region: Autotransporter; smart00869 1064551007574 outer membrane protein RatB; Provisional; Region: PRK15314 1064551007575 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1064551007576 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1064551007577 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1064551007578 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1064551007579 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1064551007580 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1064551007581 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1064551007582 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1064551007583 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1064551007584 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1064551007585 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1064551007586 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1064551007587 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1064551007588 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1064551007589 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1064551007590 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1064551007591 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1064551007592 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1064551007593 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1064551007594 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1064551007595 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1064551007596 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1064551007597 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1064551007598 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1064551007599 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1064551007600 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1064551007601 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 1064551007602 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 1064551007603 intimin-like protein SinH; Provisional; Region: PRK15318 1064551007604 intimin-like protein SinH; Provisional; Region: PRK15318 1064551007605 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1064551007606 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 1064551007607 GTP-binding protein Der; Reviewed; Region: PRK00093 1064551007608 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1064551007609 G1 box; other site 1064551007610 GTP/Mg2+ binding site [chemical binding]; other site 1064551007611 Switch I region; other site 1064551007612 G2 box; other site 1064551007613 Switch II region; other site 1064551007614 G3 box; other site 1064551007615 G4 box; other site 1064551007616 G5 box; other site 1064551007617 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1064551007618 G1 box; other site 1064551007619 GTP/Mg2+ binding site [chemical binding]; other site 1064551007620 Switch I region; other site 1064551007621 G2 box; other site 1064551007622 G3 box; other site 1064551007623 Switch II region; other site 1064551007624 G4 box; other site 1064551007625 G5 box; other site 1064551007626 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 1064551007627 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 1064551007628 Trp docking motif [polypeptide binding]; other site 1064551007629 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1064551007630 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 1064551007631 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1064551007632 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1064551007633 dimer interface [polypeptide binding]; other site 1064551007634 motif 1; other site 1064551007635 active site 1064551007636 motif 2; other site 1064551007637 motif 3; other site 1064551007638 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1064551007639 anticodon binding site; other site 1064551007640 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1064551007641 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1064551007642 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1064551007643 cytoskeletal protein RodZ; Provisional; Region: PRK10856 1064551007644 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064551007645 non-specific DNA binding site [nucleotide binding]; other site 1064551007646 salt bridge; other site 1064551007647 sequence-specific DNA binding site [nucleotide binding]; other site 1064551007648 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1064551007649 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1064551007650 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064551007651 FeS/SAM binding site; other site 1064551007652 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1064551007653 active site 1064551007654 multimer interface [polypeptide binding]; other site 1064551007655 4Fe-4S binding domain; Region: Fer4; pfam00037 1064551007656 hydrogenase 4 subunit H; Validated; Region: PRK08222 1064551007657 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 1064551007658 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1064551007659 4Fe-4S binding domain; Region: Fer4; pfam00037 1064551007660 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1064551007661 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1064551007662 putative [Fe4-S4] binding site [ion binding]; other site 1064551007663 putative molybdopterin cofactor binding site [chemical binding]; other site 1064551007664 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1064551007665 putative molybdopterin cofactor binding site; other site 1064551007666 penicillin-binding protein 1C; Provisional; Region: PRK11240 1064551007667 Transglycosylase; Region: Transgly; pfam00912 1064551007668 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1064551007669 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 1064551007670 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1064551007671 MG2 domain; Region: A2M_N; pfam01835 1064551007672 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1064551007673 surface patch; other site 1064551007674 thioester region; other site 1064551007675 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 1064551007676 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1064551007677 active site residue [active] 1064551007678 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1064551007679 active site residue [active] 1064551007680 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 1064551007681 aminopeptidase B; Provisional; Region: PRK05015 1064551007682 Peptidase; Region: DUF3663; pfam12404 1064551007683 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1064551007684 interface (dimer of trimers) [polypeptide binding]; other site 1064551007685 Substrate-binding/catalytic site; other site 1064551007686 Zn-binding sites [ion binding]; other site 1064551007687 hypothetical protein; Provisional; Region: PRK10721 1064551007688 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1064551007689 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1064551007690 catalytic loop [active] 1064551007691 iron binding site [ion binding]; other site 1064551007692 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1064551007693 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 1064551007694 nucleotide binding site [chemical binding]; other site 1064551007695 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1064551007696 SBD interface [polypeptide binding]; other site 1064551007697 co-chaperone HscB; Provisional; Region: hscB; PRK05014 1064551007698 DnaJ domain; Region: DnaJ; pfam00226 1064551007699 HSP70 interaction site [polypeptide binding]; other site 1064551007700 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 1064551007701 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 1064551007702 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1064551007703 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1064551007704 trimerization site [polypeptide binding]; other site 1064551007705 active site 1064551007706 cysteine desulfurase; Provisional; Region: PRK14012 1064551007707 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1064551007708 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1064551007709 catalytic residue [active] 1064551007710 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 1064551007711 Rrf2 family protein; Region: rrf2_super; TIGR00738 1064551007712 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 1064551007713 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1064551007714 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1064551007715 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1064551007716 active site 1064551007717 dimerization interface [polypeptide binding]; other site 1064551007718 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1064551007719 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1064551007720 sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910 1064551007721 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1064551007722 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 1064551007723 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 1064551007724 FAD binding pocket [chemical binding]; other site 1064551007725 FAD binding motif [chemical binding]; other site 1064551007726 phosphate binding motif [ion binding]; other site 1064551007727 beta-alpha-beta structure motif; other site 1064551007728 NAD binding pocket [chemical binding]; other site 1064551007729 Iron coordination center [ion binding]; other site 1064551007730 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 1064551007731 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1064551007732 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1064551007733 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 1064551007734 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 1064551007735 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 1064551007736 PRD domain; Region: PRD; pfam00874 1064551007737 PRD domain; Region: PRD; pfam00874 1064551007738 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1064551007739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551007740 putative substrate translocation pore; other site 1064551007741 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1064551007742 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1064551007743 dimer interface [polypeptide binding]; other site 1064551007744 active site 1064551007745 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1064551007746 folate binding site [chemical binding]; other site 1064551007747 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1064551007748 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1064551007749 heme-binding site [chemical binding]; other site 1064551007750 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1064551007751 FAD binding pocket [chemical binding]; other site 1064551007752 FAD binding motif [chemical binding]; other site 1064551007753 phosphate binding motif [ion binding]; other site 1064551007754 beta-alpha-beta structure motif; other site 1064551007755 NAD binding pocket [chemical binding]; other site 1064551007756 Heme binding pocket [chemical binding]; other site 1064551007757 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 1064551007758 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1064551007759 DNA binding site [nucleotide binding] 1064551007760 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 1064551007761 lysine decarboxylase CadA; Provisional; Region: PRK15400 1064551007762 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1064551007763 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1064551007764 homodimer interface [polypeptide binding]; other site 1064551007765 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551007766 catalytic residue [active] 1064551007767 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1064551007768 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1064551007769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551007770 putative substrate translocation pore; other site 1064551007771 POT family; Region: PTR2; pfam00854 1064551007772 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 1064551007773 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1064551007774 response regulator GlrR; Provisional; Region: PRK15115 1064551007775 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064551007776 active site 1064551007777 phosphorylation site [posttranslational modification] 1064551007778 intermolecular recognition site; other site 1064551007779 dimerization interface [polypeptide binding]; other site 1064551007780 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064551007781 Walker A motif; other site 1064551007782 ATP binding site [chemical binding]; other site 1064551007783 Walker B motif; other site 1064551007784 arginine finger; other site 1064551007785 hypothetical protein; Provisional; Region: PRK10722 1064551007786 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064551007787 HAMP domain; Region: HAMP; pfam00672 1064551007788 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064551007789 dimer interface [polypeptide binding]; other site 1064551007790 phosphorylation site [posttranslational modification] 1064551007791 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064551007792 ATP binding site [chemical binding]; other site 1064551007793 Mg2+ binding site [ion binding]; other site 1064551007794 G-X-G motif; other site 1064551007795 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1064551007796 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1064551007797 dimerization interface [polypeptide binding]; other site 1064551007798 ATP binding site [chemical binding]; other site 1064551007799 Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of...; Region: PurL; cd02193 1064551007800 dimerization interface [polypeptide binding]; other site 1064551007801 ATP binding site [chemical binding]; other site 1064551007802 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1064551007803 putative active site [active] 1064551007804 catalytic triad [active] 1064551007805 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 1064551007806 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064551007807 substrate binding pocket [chemical binding]; other site 1064551007808 membrane-bound complex binding site; other site 1064551007809 hinge residues; other site 1064551007810 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1064551007811 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1064551007812 catalytic residue [active] 1064551007813 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1064551007814 nucleoside/Zn binding site; other site 1064551007815 dimer interface [polypeptide binding]; other site 1064551007816 catalytic motif [active] 1064551007817 hypothetical protein; Provisional; Region: PRK11590 1064551007818 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1064551007819 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1064551007820 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1064551007821 active site turn [active] 1064551007822 phosphorylation site [posttranslational modification] 1064551007823 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1064551007824 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1064551007825 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1064551007826 putative active site [active] 1064551007827 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1064551007828 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 1064551007829 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1064551007830 putative active site [active] 1064551007831 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1064551007832 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1064551007833 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1064551007834 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1064551007835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551007836 putative substrate translocation pore; other site 1064551007837 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064551007838 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551007839 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1064551007840 dimerization interface [polypeptide binding]; other site 1064551007841 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1064551007842 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1064551007843 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1064551007844 active site 1064551007845 hydrophilic channel; other site 1064551007846 dimerization interface [polypeptide binding]; other site 1064551007847 catalytic residues [active] 1064551007848 active site lid [active] 1064551007849 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1064551007850 Recombination protein O N terminal; Region: RecO_N; pfam11967 1064551007851 Recombination protein O C terminal; Region: RecO_C; pfam02565 1064551007852 GTPase Era; Reviewed; Region: era; PRK00089 1064551007853 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1064551007854 G1 box; other site 1064551007855 GTP/Mg2+ binding site [chemical binding]; other site 1064551007856 Switch I region; other site 1064551007857 G2 box; other site 1064551007858 Switch II region; other site 1064551007859 G3 box; other site 1064551007860 G4 box; other site 1064551007861 G5 box; other site 1064551007862 KH domain; Region: KH_2; pfam07650 1064551007863 ribonuclease III; Reviewed; Region: rnc; PRK00102 1064551007864 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1064551007865 dimerization interface [polypeptide binding]; other site 1064551007866 active site 1064551007867 metal binding site [ion binding]; metal-binding site 1064551007868 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1064551007869 dsRNA binding site [nucleotide binding]; other site 1064551007870 signal peptidase I; Provisional; Region: PRK10861 1064551007871 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1064551007872 Catalytic site [active] 1064551007873 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1064551007874 GTP-binding protein LepA; Provisional; Region: PRK05433 1064551007875 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1064551007876 G1 box; other site 1064551007877 putative GEF interaction site [polypeptide binding]; other site 1064551007878 GTP/Mg2+ binding site [chemical binding]; other site 1064551007879 Switch I region; other site 1064551007880 G2 box; other site 1064551007881 G3 box; other site 1064551007882 Switch II region; other site 1064551007883 G4 box; other site 1064551007884 G5 box; other site 1064551007885 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1064551007886 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1064551007887 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1064551007888 SoxR reducing system protein RseC; Provisional; Region: PRK10862 1064551007889 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 1064551007890 anti-sigma E factor; Provisional; Region: rseB; PRK09455 1064551007891 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 1064551007892 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 1064551007893 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 1064551007894 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 1064551007895 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1064551007896 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1064551007897 DNA binding residues [nucleotide binding] 1064551007898 L-aspartate oxidase; Provisional; Region: PRK09077 1064551007899 L-aspartate oxidase; Provisional; Region: PRK06175 1064551007900 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1064551007901 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1064551007902 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064551007903 S-adenosylmethionine binding site [chemical binding]; other site 1064551007904 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1064551007905 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1064551007906 ATP binding site [chemical binding]; other site 1064551007907 Mg++ binding site [ion binding]; other site 1064551007908 motif III; other site 1064551007909 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1064551007910 nucleotide binding region [chemical binding]; other site 1064551007911 ATP-binding site [chemical binding]; other site 1064551007912 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064551007913 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551007914 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1064551007915 dimerization interface [polypeptide binding]; other site 1064551007916 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 1064551007917 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 1064551007918 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1064551007919 ligand binding site [chemical binding]; other site 1064551007920 active site 1064551007921 UGI interface [polypeptide binding]; other site 1064551007922 catalytic site [active] 1064551007923 putative methyltransferase; Provisional; Region: PRK10864 1064551007924 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1064551007925 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1064551007926 thioredoxin 2; Provisional; Region: PRK10996 1064551007927 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 1064551007928 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1064551007929 catalytic residues [active] 1064551007930 Uncharacterized conserved protein [Function unknown]; Region: COG3148 1064551007931 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1064551007932 CoA binding domain; Region: CoA_binding_2; pfam13380 1064551007933 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1064551007934 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1064551007935 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1064551007936 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064551007937 Coenzyme A binding pocket [chemical binding]; other site 1064551007938 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 1064551007939 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 1064551007940 domain interface [polypeptide binding]; other site 1064551007941 putative active site [active] 1064551007942 catalytic site [active] 1064551007943 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 1064551007944 domain interface [polypeptide binding]; other site 1064551007945 putative active site [active] 1064551007946 catalytic site [active] 1064551007947 lipoprotein; Provisional; Region: PRK10759 1064551007948 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1064551007949 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551007950 putative substrate translocation pore; other site 1064551007951 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 1064551007952 protein disaggregation chaperone; Provisional; Region: PRK10865 1064551007953 Clp amino terminal domain; Region: Clp_N; pfam02861 1064551007954 Clp amino terminal domain; Region: Clp_N; pfam02861 1064551007955 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064551007956 Walker A motif; other site 1064551007957 ATP binding site [chemical binding]; other site 1064551007958 Walker B motif; other site 1064551007959 arginine finger; other site 1064551007960 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064551007961 Walker A motif; other site 1064551007962 ATP binding site [chemical binding]; other site 1064551007963 Walker B motif; other site 1064551007964 arginine finger; other site 1064551007965 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1064551007966 hypothetical protein; Provisional; Region: PRK10723 1064551007967 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1064551007968 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1064551007969 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1064551007970 RNA binding surface [nucleotide binding]; other site 1064551007971 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1064551007972 active site 1064551007973 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 1064551007974 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 1064551007975 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1064551007976 30S subunit binding site; other site 1064551007977 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 1064551007978 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 1064551007979 Prephenate dehydratase; Region: PDT; pfam00800 1064551007980 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1064551007981 putative L-Phe binding site [chemical binding]; other site 1064551007982 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1064551007983 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 1064551007984 Chorismate mutase type II; Region: CM_2; cl00693 1064551007985 prephenate dehydrogenase; Validated; Region: PRK08507 1064551007986 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1064551007987 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1064551007988 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 1064551007989 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 1064551007990 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064551007991 metal binding site [ion binding]; metal-binding site 1064551007992 active site 1064551007993 I-site; other site 1064551007994 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1064551007995 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1064551007996 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1064551007997 RimM N-terminal domain; Region: RimM; pfam01782 1064551007998 PRC-barrel domain; Region: PRC; pfam05239 1064551007999 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1064551008000 signal recognition particle protein; Provisional; Region: PRK10867 1064551008001 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1064551008002 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1064551008003 P loop; other site 1064551008004 GTP binding site [chemical binding]; other site 1064551008005 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1064551008006 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 1064551008007 hypothetical protein; Provisional; Region: PRK11573 1064551008008 Domain of unknown function DUF21; Region: DUF21; pfam01595 1064551008009 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1064551008010 Transporter associated domain; Region: CorC_HlyC; smart01091 1064551008011 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1064551008012 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1064551008013 dimer interface [polypeptide binding]; other site 1064551008014 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1064551008015 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 1064551008016 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1064551008017 recombination and repair protein; Provisional; Region: PRK10869 1064551008018 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1064551008019 Walker A/P-loop; other site 1064551008020 ATP binding site [chemical binding]; other site 1064551008021 Q-loop/lid; other site 1064551008022 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1064551008023 ABC transporter signature motif; other site 1064551008024 Walker B; other site 1064551008025 D-loop; other site 1064551008026 H-loop/switch region; other site 1064551008027 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 1064551008028 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1064551008029 hypothetical protein; Validated; Region: PRK01777 1064551008030 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1064551008031 putative coenzyme Q binding site [chemical binding]; other site 1064551008032 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1064551008033 SmpB-tmRNA interface; other site 1064551008034 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064551008035 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064551008036 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064551008037 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064551008038 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064551008039 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064551008040 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064551008041 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064551008042 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064551008043 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064551008044 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064551008045 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1064551008046 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064551008047 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064551008048 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1064551008049 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064551008050 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064551008051 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 1064551008052 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1064551008053 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 1064551008054 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1064551008055 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064551008056 Walker A/P-loop; other site 1064551008057 ATP binding site [chemical binding]; other site 1064551008058 Q-loop/lid; other site 1064551008059 ABC transporter signature motif; other site 1064551008060 Walker B; other site 1064551008061 D-loop; other site 1064551008062 H-loop/switch region; other site 1064551008063 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1064551008064 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064551008065 integrase; Provisional; Region: PRK09692 1064551008066 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1064551008067 active site 1064551008068 Int/Topo IB signature motif; other site 1064551008069 Domain of unknown function DUF87; Region: DUF87; pfam01935 1064551008070 HerA helicase [Replication, recombination, and repair]; Region: COG0433 1064551008071 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 1064551008072 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 1064551008073 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 1064551008074 Repressor of phase-1 flagellin; Region: Flag1_repress; pfam03614 1064551008075 flagellin; Validated; Region: PRK08026 1064551008076 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1064551008077 Flagellin D3 domain; Region: Flagellin_D3; pfam08884 1064551008078 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1064551008079 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1064551008080 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1064551008081 catalytic residues [active] 1064551008082 catalytic nucleophile [active] 1064551008083 Presynaptic Site I dimer interface [polypeptide binding]; other site 1064551008084 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1064551008085 Synaptic Flat tetramer interface [polypeptide binding]; other site 1064551008086 Synaptic Site I dimer interface [polypeptide binding]; other site 1064551008087 DNA binding site [nucleotide binding] 1064551008088 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1064551008089 DNA-binding interface [nucleotide binding]; DNA binding site 1064551008090 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1064551008091 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1064551008092 homodimer interface [polypeptide binding]; other site 1064551008093 active site 1064551008094 TDP-binding site; other site 1064551008095 acceptor substrate-binding pocket; other site 1064551008096 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1064551008097 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064551008098 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1064551008099 Walker A/P-loop; other site 1064551008100 ATP binding site [chemical binding]; other site 1064551008101 Q-loop/lid; other site 1064551008102 ABC transporter signature motif; other site 1064551008103 Walker B; other site 1064551008104 D-loop; other site 1064551008105 H-loop/switch region; other site 1064551008106 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1064551008107 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1064551008108 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064551008109 Walker A/P-loop; other site 1064551008110 ATP binding site [chemical binding]; other site 1064551008111 Q-loop/lid; other site 1064551008112 ABC transporter signature motif; other site 1064551008113 Walker B; other site 1064551008114 D-loop; other site 1064551008115 H-loop/switch region; other site 1064551008116 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1064551008117 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 1064551008118 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1064551008119 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1064551008120 outer membrane receptor FepA; Provisional; Region: PRK13528 1064551008121 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1064551008122 N-terminal plug; other site 1064551008123 ligand-binding site [chemical binding]; other site 1064551008124 secreted effector protein PipB2; Provisional; Region: PRK15196 1064551008125 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064551008126 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064551008127 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064551008128 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064551008129 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1064551008130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 1064551008131 antimicrobial resistance protein Mig-14; Provisional; Region: PRK15312 1064551008132 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1064551008133 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1064551008134 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1064551008135 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1064551008136 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1064551008137 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064551008138 dimer interface [polypeptide binding]; other site 1064551008139 phosphorylation site [posttranslational modification] 1064551008140 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064551008141 ATP binding site [chemical binding]; other site 1064551008142 Mg2+ binding site [ion binding]; other site 1064551008143 G-X-G motif; other site 1064551008144 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 1064551008145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064551008146 active site 1064551008147 phosphorylation site [posttranslational modification] 1064551008148 intermolecular recognition site; other site 1064551008149 dimerization interface [polypeptide binding]; other site 1064551008150 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1064551008151 DNA binding site [nucleotide binding] 1064551008152 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1064551008153 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1064551008154 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1064551008155 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 1064551008156 substrate binding pocket [chemical binding]; other site 1064551008157 active site 1064551008158 iron coordination sites [ion binding]; other site 1064551008159 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1064551008160 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1064551008161 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 1064551008162 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1064551008163 tetramerization interface [polypeptide binding]; other site 1064551008164 NAD(P) binding site [chemical binding]; other site 1064551008165 catalytic residues [active] 1064551008166 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 1064551008167 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1064551008168 inhibitor-cofactor binding pocket; inhibition site 1064551008169 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551008170 catalytic residue [active] 1064551008171 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 1064551008172 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 1064551008173 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064551008174 DNA-binding site [nucleotide binding]; DNA binding site 1064551008175 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1064551008176 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1064551008177 bacterial OsmY and nodulation domain; Region: BON; smart00749 1064551008178 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1064551008179 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 1064551008180 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1064551008181 dimerization interface [polypeptide binding]; other site 1064551008182 putative DNA binding site [nucleotide binding]; other site 1064551008183 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1064551008184 putative Zn2+ binding site [ion binding]; other site 1064551008185 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1064551008186 active site residue [active] 1064551008187 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1064551008188 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 1064551008189 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1064551008190 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 1064551008191 hypothetical protein; Provisional; Region: PRK10556 1064551008192 hypothetical protein; Provisional; Region: PRK10132 1064551008193 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1064551008194 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064551008195 DNA-binding site [nucleotide binding]; DNA binding site 1064551008196 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1064551008197 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551008198 homodimer interface [polypeptide binding]; other site 1064551008199 catalytic residue [active] 1064551008200 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1064551008201 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1064551008202 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1064551008203 catalytic residues [active] 1064551008204 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1064551008205 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1064551008206 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1064551008207 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1064551008208 active site 1064551008209 dimer interface [polypeptide binding]; other site 1064551008210 catalytic residues [active] 1064551008211 effector binding site; other site 1064551008212 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1064551008213 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1064551008214 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1064551008215 dimer interface [polypeptide binding]; other site 1064551008216 putative radical transfer pathway; other site 1064551008217 diiron center [ion binding]; other site 1064551008218 tyrosyl radical; other site 1064551008219 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 1064551008220 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1064551008221 Walker A/P-loop; other site 1064551008222 ATP binding site [chemical binding]; other site 1064551008223 Q-loop/lid; other site 1064551008224 ABC transporter signature motif; other site 1064551008225 Walker B; other site 1064551008226 D-loop; other site 1064551008227 H-loop/switch region; other site 1064551008228 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1064551008229 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1064551008230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551008231 dimer interface [polypeptide binding]; other site 1064551008232 conserved gate region; other site 1064551008233 putative PBP binding loops; other site 1064551008234 ABC-ATPase subunit interface; other site 1064551008235 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 1064551008236 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1064551008237 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1064551008238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551008239 transcriptional repressor MprA; Provisional; Region: PRK10870 1064551008240 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1064551008241 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 1064551008242 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1064551008243 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064551008244 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1064551008245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551008246 putative substrate translocation pore; other site 1064551008247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551008248 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 1064551008249 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1064551008250 glutamate--cysteine ligase; Provisional; Region: PRK02107 1064551008251 Predicted membrane protein [Function unknown]; Region: COG1238 1064551008252 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 1064551008253 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064551008254 motif II; other site 1064551008255 carbon storage regulator; Provisional; Region: PRK01712 1064551008256 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1064551008257 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1064551008258 motif 1; other site 1064551008259 active site 1064551008260 motif 2; other site 1064551008261 motif 3; other site 1064551008262 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1064551008263 DHHA1 domain; Region: DHHA1; pfam02272 1064551008264 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1064551008265 recombinase A; Provisional; Region: recA; PRK09354 1064551008266 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1064551008267 hexamer interface [polypeptide binding]; other site 1064551008268 Walker A motif; other site 1064551008269 ATP binding site [chemical binding]; other site 1064551008270 Walker B motif; other site 1064551008271 hypothetical protein; Validated; Region: PRK03661 1064551008272 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1064551008273 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1064551008274 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1064551008275 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 1064551008276 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 1064551008277 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1064551008278 Nucleoside recognition; Region: Gate; pfam07670 1064551008279 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 1064551008280 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 1064551008281 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 1064551008282 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 1064551008283 putative NAD(P) binding site [chemical binding]; other site 1064551008284 active site 1064551008285 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 1064551008286 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 1064551008287 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1064551008288 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1064551008289 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 1064551008290 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1064551008291 putative active site [active] 1064551008292 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1064551008293 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 1064551008294 GAF domain; Region: GAF; pfam01590 1064551008295 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064551008296 Walker A motif; other site 1064551008297 ATP binding site [chemical binding]; other site 1064551008298 Walker B motif; other site 1064551008299 arginine finger; other site 1064551008300 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 1064551008301 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1064551008302 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1064551008303 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1064551008304 iron binding site [ion binding]; other site 1064551008305 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 1064551008306 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1064551008307 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1064551008308 Acylphosphatase; Region: Acylphosphatase; pfam00708 1064551008309 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1064551008310 HypF finger; Region: zf-HYPF; pfam07503 1064551008311 HypF finger; Region: zf-HYPF; pfam07503 1064551008312 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1064551008313 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 1064551008314 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1064551008315 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 1064551008316 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 1064551008317 nickel binding site [ion binding]; other site 1064551008318 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 1064551008319 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1064551008320 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 1064551008321 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1064551008322 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 1064551008323 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1064551008324 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1064551008325 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1064551008326 NADH dehydrogenase; Region: NADHdh; cl00469 1064551008327 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 1064551008328 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1064551008329 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1064551008330 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 1064551008331 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 1064551008332 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 1064551008333 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 1064551008334 hydrogenase assembly chaperone; Provisional; Region: PRK10409 1064551008335 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 1064551008336 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 1064551008337 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 1064551008338 dimerization interface [polypeptide binding]; other site 1064551008339 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 1064551008340 ATP binding site [chemical binding]; other site 1064551008341 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 1064551008342 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1064551008343 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1064551008344 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064551008345 Walker A motif; other site 1064551008346 ATP binding site [chemical binding]; other site 1064551008347 Walker B motif; other site 1064551008348 arginine finger; other site 1064551008349 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1064551008350 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 1064551008351 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1064551008352 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1064551008353 metal binding site [ion binding]; metal-binding site 1064551008354 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 1064551008355 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1064551008356 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1064551008357 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1064551008358 ABC-ATPase subunit interface; other site 1064551008359 dimer interface [polypeptide binding]; other site 1064551008360 putative PBP binding regions; other site 1064551008361 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1064551008362 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1064551008363 ABC-ATPase subunit interface; other site 1064551008364 dimer interface [polypeptide binding]; other site 1064551008365 putative PBP binding regions; other site 1064551008366 effector protein YopJ; Provisional; Region: PRK15371 1064551008367 transcriptional activator SprB; Provisional; Region: PRK15320 1064551008368 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 1064551008369 transcriptional regulator SirC; Provisional; Region: PRK15044 1064551008370 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064551008371 putative type III secretion system effector protein OrgC; Provisional; Region: PRK15321 1064551008372 invasion protein OrgB; Provisional; Region: PRK15322 1064551008373 type III secretion apparatus protein OrgA/MxiK; Region: OrgA_MxiK; TIGR02555 1064551008374 invasion protein OrgA; Provisional; Region: PRK15323 1064551008375 type III secretion system lipoprotein PrgK; Provisional; Region: PRK15324 1064551008376 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 1064551008377 type III secretion system needle complex protein PrgI; Provisional; Region: PRK15326 1064551008378 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327 1064551008379 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 1064551008380 transcriptional regulator HilD; Provisional; Region: PRK15185 1064551008381 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064551008382 invasion protein regulator; Provisional; Region: PRK12370 1064551008383 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1064551008384 DNA binding site [nucleotide binding] 1064551008385 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064551008386 binding surface 1064551008387 TPR motif; other site 1064551008388 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1064551008389 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1064551008390 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1064551008391 catalytic residue [active] 1064551008392 pathogenicity island 1 effector protein StpP; Provisional; Region: PRK15375 1064551008393 SicP binding; Region: SicP-binding; pfam09119 1064551008394 GTPase-activating protein (GAP) domain found in bacterial cytotoxins, ExoS, SptP, and YopE. Part of protein secretion system; stimulates Rac1- dependent cytoskeletal changes that promote bacterial internalization; Region: ToxGAP; cd00219 1064551008395 switch II binding region; other site 1064551008396 Rac1 P-loop interaction site [polypeptide binding]; other site 1064551008397 GTP binding residues [chemical binding]; other site 1064551008398 switch I binding region; other site 1064551008399 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047 1064551008400 active site 1064551008401 chaperone protein SicP; Provisional; Region: PRK15329 1064551008402 putative acyl carrier protein IacP; Validated; Region: PRK08172 1064551008403 pathogenicity island 1 effector protein SipA; Provisional; Region: PRK15376 1064551008404 cell invasion protein SipD; Provisional; Region: PRK15330 1064551008405 pathogenicity island 1 effector protein SipC; Provisional; Region: PRK15373 1064551008406 pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374 1064551008407 chaperone protein SicA; Provisional; Region: PRK15331 1064551008408 Tetratricopeptide repeat; Region: TPR_3; pfam07720 1064551008409 Tetratricopeptide repeat; Region: TPR_3; pfam07720 1064551008410 type III secretion system protein SpaS; Validated; Region: PRK08156 1064551008411 type III secretion system protein SpaR; Provisional; Region: PRK15332 1064551008412 type III secretion system protein SpaQ; Provisional; Region: PRK15333 1064551008413 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 1064551008414 type III secretion system protein SpaO; Validated; Region: PRK08158 1064551008415 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 1064551008416 antigen presentation protein SpaN; Provisional; Region: PRK15334 1064551008417 Surface presentation of antigens protein; Region: SPAN; pfam02510 1064551008418 Salmonella surface presentation of antigen gene type M protein; Region: SPAM; pfam02090 1064551008419 ATP synthase SpaL; Validated; Region: PRK08149 1064551008420 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1064551008421 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1064551008422 Walker A motif; other site 1064551008423 ATP binding site [chemical binding]; other site 1064551008424 Walker B motif; other site 1064551008425 type III secretion system chaperone SpaK; Provisional; Region: PRK15336 1064551008426 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 1064551008427 type III secretion system protein InvA; Provisional; Region: PRK15337 1064551008428 type III secretion system regulator InvE; Provisional; Region: PRK15338 1064551008429 type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568 1064551008430 type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339 1064551008431 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1064551008432 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1064551008433 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1064551008434 transcriptional regulator InvF; Provisional; Region: PRK15340 1064551008435 InvH outer membrane lipoprotein; Region: InvH; pfam04741 1064551008436 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1064551008437 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1064551008438 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 1064551008439 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1064551008440 active site 1064551008441 metal binding site [ion binding]; metal-binding site 1064551008442 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1064551008443 MutS domain I; Region: MutS_I; pfam01624 1064551008444 MutS domain II; Region: MutS_II; pfam05188 1064551008445 MutS domain III; Region: MutS_III; pfam05192 1064551008446 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1064551008447 Walker A/P-loop; other site 1064551008448 ATP binding site [chemical binding]; other site 1064551008449 Q-loop/lid; other site 1064551008450 ABC transporter signature motif; other site 1064551008451 Walker B; other site 1064551008452 D-loop; other site 1064551008453 H-loop/switch region; other site 1064551008454 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 1064551008455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551008456 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1064551008457 putative substrate translocation pore; other site 1064551008458 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064551008459 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551008460 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1064551008461 putative effector binding pocket; other site 1064551008462 dimerization interface [polypeptide binding]; other site 1064551008463 GntP family permease; Region: GntP_permease; pfam02447 1064551008464 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1064551008465 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1064551008466 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 1064551008467 putative NAD(P) binding site [chemical binding]; other site 1064551008468 active site 1064551008469 putative substrate binding site [chemical binding]; other site 1064551008470 hypothetical protein; Provisional; Region: PRK09989 1064551008471 putative aldolase; Validated; Region: PRK08130 1064551008472 intersubunit interface [polypeptide binding]; other site 1064551008473 active site 1064551008474 Zn2+ binding site [ion binding]; other site 1064551008475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1064551008476 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1064551008477 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1064551008478 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1064551008479 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1064551008480 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1064551008481 MarR family; Region: MarR_2; cl17246 1064551008482 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1064551008483 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1064551008484 Flavoprotein; Region: Flavoprotein; pfam02441 1064551008485 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 1064551008486 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 1064551008487 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1064551008488 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1064551008489 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1064551008490 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1064551008491 DNA binding residues [nucleotide binding] 1064551008492 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 1064551008493 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1064551008494 Peptidase family M23; Region: Peptidase_M23; pfam01551 1064551008495 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1064551008496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064551008497 S-adenosylmethionine binding site [chemical binding]; other site 1064551008498 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1064551008499 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 1064551008500 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 1064551008501 Permutation of conserved domain; other site 1064551008502 active site 1064551008503 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1064551008504 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1064551008505 homotrimer interaction site [polypeptide binding]; other site 1064551008506 zinc binding site [ion binding]; other site 1064551008507 CDP-binding sites; other site 1064551008508 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1064551008509 substrate binding site; other site 1064551008510 dimer interface; other site 1064551008511 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 1064551008512 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1064551008513 Protein of unknown function (DUF3561); Region: DUF3561; cl08142 1064551008514 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1064551008515 ligand-binding site [chemical binding]; other site 1064551008516 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 1064551008517 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1064551008518 CysD dimerization site [polypeptide binding]; other site 1064551008519 G1 box; other site 1064551008520 putative GEF interaction site [polypeptide binding]; other site 1064551008521 GTP/Mg2+ binding site [chemical binding]; other site 1064551008522 Switch I region; other site 1064551008523 G2 box; other site 1064551008524 G3 box; other site 1064551008525 Switch II region; other site 1064551008526 G4 box; other site 1064551008527 G5 box; other site 1064551008528 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1064551008529 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1064551008530 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1064551008531 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1064551008532 Active Sites [active] 1064551008533 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 1064551008534 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1064551008535 metal binding site [ion binding]; metal-binding site 1064551008536 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 1064551008537 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 1064551008538 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 1064551008539 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1064551008540 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 1064551008541 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646 1064551008542 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 1064551008543 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 1064551008544 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1064551008545 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 1064551008546 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1064551008547 pathogenicity island 1 effector protein SopD; Provisional; Region: PRK15379 1064551008548 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1064551008549 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1064551008550 Active Sites [active] 1064551008551 sulfite reductase subunit beta; Provisional; Region: PRK13504 1064551008552 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1064551008553 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1064551008554 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 1064551008555 Flavodoxin; Region: Flavodoxin_1; pfam00258 1064551008556 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1064551008557 FAD binding pocket [chemical binding]; other site 1064551008558 FAD binding motif [chemical binding]; other site 1064551008559 catalytic residues [active] 1064551008560 NAD binding pocket [chemical binding]; other site 1064551008561 phosphate binding motif [ion binding]; other site 1064551008562 beta-alpha-beta structure motif; other site 1064551008563 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1064551008564 active site 1064551008565 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 1064551008566 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 1064551008567 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1064551008568 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1064551008569 enolase; Provisional; Region: eno; PRK00077 1064551008570 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1064551008571 dimer interface [polypeptide binding]; other site 1064551008572 metal binding site [ion binding]; metal-binding site 1064551008573 substrate binding pocket [chemical binding]; other site 1064551008574 CTP synthetase; Validated; Region: pyrG; PRK05380 1064551008575 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1064551008576 Catalytic site [active] 1064551008577 active site 1064551008578 UTP binding site [chemical binding]; other site 1064551008579 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1064551008580 active site 1064551008581 putative oxyanion hole; other site 1064551008582 catalytic triad [active] 1064551008583 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1064551008584 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1064551008585 homodimer interface [polypeptide binding]; other site 1064551008586 metal binding site [ion binding]; metal-binding site 1064551008587 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1064551008588 homodimer interface [polypeptide binding]; other site 1064551008589 active site 1064551008590 putative chemical substrate binding site [chemical binding]; other site 1064551008591 metal binding site [ion binding]; metal-binding site 1064551008592 fimbrial protein SteA; Provisional; Region: PRK15261 1064551008593 putative fimbrial outer membrane usher protein SteB; Provisional; Region: PRK15273 1064551008594 PapC N-terminal domain; Region: PapC_N; pfam13954 1064551008595 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1064551008596 PapC C-terminal domain; Region: PapC_C; pfam13953 1064551008597 putative periplasmic fimbrial chaperone protein SteC; Provisional; Region: PRK15274 1064551008598 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1064551008599 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1064551008600 putative fimbrial protein SteD; Provisional; Region: PRK15275 1064551008601 putative fimbrial subunit SteE; Provisional; Region: PRK15276 1064551008602 fimbrial protein SteF; Provisional; Region: PRK15260 1064551008603 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1064551008604 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 1064551008605 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 1064551008606 HD domain; Region: HD_4; pfam13328 1064551008607 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1064551008608 synthetase active site [active] 1064551008609 NTP binding site [chemical binding]; other site 1064551008610 metal binding site [ion binding]; metal-binding site 1064551008611 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1064551008612 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1064551008613 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1064551008614 TRAM domain; Region: TRAM; pfam01938 1064551008615 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064551008616 S-adenosylmethionine binding site [chemical binding]; other site 1064551008617 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 1064551008618 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 1064551008619 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064551008620 dimerization interface [polypeptide binding]; other site 1064551008621 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064551008622 dimer interface [polypeptide binding]; other site 1064551008623 phosphorylation site [posttranslational modification] 1064551008624 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064551008625 ATP binding site [chemical binding]; other site 1064551008626 Mg2+ binding site [ion binding]; other site 1064551008627 G-X-G motif; other site 1064551008628 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 1064551008629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064551008630 active site 1064551008631 phosphorylation site [posttranslational modification] 1064551008632 intermolecular recognition site; other site 1064551008633 dimerization interface [polypeptide binding]; other site 1064551008634 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1064551008635 putative binding surface; other site 1064551008636 active site 1064551008637 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1064551008638 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1064551008639 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1064551008640 active site 1064551008641 tetramer interface [polypeptide binding]; other site 1064551008642 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1064551008643 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1064551008644 active site 1064551008645 tetramer interface [polypeptide binding]; other site 1064551008646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551008647 D-galactonate transporter; Region: 2A0114; TIGR00893 1064551008648 putative substrate translocation pore; other site 1064551008649 flavodoxin; Provisional; Region: PRK08105 1064551008650 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1064551008651 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 1064551008652 probable active site [active] 1064551008653 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 1064551008654 SecY interacting protein Syd; Provisional; Region: PRK04968 1064551008655 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 1064551008656 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 1064551008657 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1064551008658 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1064551008659 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 1064551008660 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1064551008661 serine transporter; Region: stp; TIGR00814 1064551008662 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1064551008663 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1064551008664 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1064551008665 flap endonuclease-like protein; Provisional; Region: PRK09482 1064551008666 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1064551008667 active site 1064551008668 metal binding site 1 [ion binding]; metal-binding site 1064551008669 putative 5' ssDNA interaction site; other site 1064551008670 metal binding site 3; metal-binding site 1064551008671 metal binding site 2 [ion binding]; metal-binding site 1064551008672 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1064551008673 putative DNA binding site [nucleotide binding]; other site 1064551008674 putative metal binding site [ion binding]; other site 1064551008675 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 1064551008676 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1064551008677 dimer interface [polypeptide binding]; other site 1064551008678 active site 1064551008679 metal binding site [ion binding]; metal-binding site 1064551008680 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1064551008681 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1064551008682 intersubunit interface [polypeptide binding]; other site 1064551008683 active site 1064551008684 Zn2+ binding site [ion binding]; other site 1064551008685 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1064551008686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551008687 putative substrate translocation pore; other site 1064551008688 L-fucose isomerase; Provisional; Region: fucI; PRK10991 1064551008689 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 1064551008690 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1064551008691 trimer interface [polypeptide binding]; other site 1064551008692 substrate binding site [chemical binding]; other site 1064551008693 Mn binding site [ion binding]; other site 1064551008694 L-fuculokinase; Provisional; Region: PRK10331 1064551008695 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1064551008696 nucleotide binding site [chemical binding]; other site 1064551008697 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 1064551008698 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 1064551008699 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1064551008700 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1064551008701 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 1064551008702 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1064551008703 hypothetical protein; Provisional; Region: PRK10873 1064551008704 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1064551008705 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551008706 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1064551008707 dimerization interface [polypeptide binding]; other site 1064551008708 substrate binding pocket [chemical binding]; other site 1064551008709 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1064551008710 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1064551008711 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1064551008712 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1064551008713 catalytic residue [active] 1064551008714 CsdA-binding activator; Provisional; Region: PRK15019 1064551008715 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1064551008716 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 1064551008717 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1064551008718 putative ATP binding site [chemical binding]; other site 1064551008719 putative substrate interface [chemical binding]; other site 1064551008720 murein transglycosylase A; Provisional; Region: mltA; PRK11162 1064551008721 murein hydrolase B; Provisional; Region: PRK10760; cl17906 1064551008722 MltA specific insert domain; Region: MltA; pfam03562 1064551008723 3D domain; Region: 3D; pfam06725 1064551008724 AMIN domain; Region: AMIN; pfam11741 1064551008725 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1064551008726 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1064551008727 active site 1064551008728 metal binding site [ion binding]; metal-binding site 1064551008729 N-acetylglutamate synthase; Validated; Region: PRK05279 1064551008730 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1064551008731 putative feedback inhibition sensing region; other site 1064551008732 putative nucleotide binding site [chemical binding]; other site 1064551008733 putative substrate binding site [chemical binding]; other site 1064551008734 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064551008735 Coenzyme A binding pocket [chemical binding]; other site 1064551008736 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 1064551008737 AAA domain; Region: AAA_30; pfam13604 1064551008738 Family description; Region: UvrD_C_2; pfam13538 1064551008739 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 1064551008740 protease3; Provisional; Region: PRK15101 1064551008741 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1064551008742 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1064551008743 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1064551008744 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 1064551008745 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1064551008746 hypothetical protein; Provisional; Region: PRK10332 1064551008747 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 1064551008748 hypothetical protein; Provisional; Region: PRK11521 1064551008749 hypothetical protein; Provisional; Region: PRK10557 1064551008750 hypothetical protein; Provisional; Region: PRK10506 1064551008751 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1064551008752 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1064551008753 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1064551008754 dimerization interface [polypeptide binding]; other site 1064551008755 active site 1064551008756 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1064551008757 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 1064551008758 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1064551008759 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1064551008760 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1064551008761 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1064551008762 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1064551008763 putative active site [active] 1064551008764 Ap4A binding site [chemical binding]; other site 1064551008765 nudix motif; other site 1064551008766 putative metal binding site [ion binding]; other site 1064551008767 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 1064551008768 putative DNA-binding cleft [nucleotide binding]; other site 1064551008769 putative DNA clevage site; other site 1064551008770 molecular lever; other site 1064551008771 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1064551008772 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1064551008773 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1064551008774 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1064551008775 active site 1064551008776 catalytic tetrad [active] 1064551008777 lysophospholipid transporter LplT; Provisional; Region: PRK11195 1064551008778 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551008779 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 1064551008780 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1064551008781 putative acyl-acceptor binding pocket; other site 1064551008782 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 1064551008783 acyl-activating enzyme (AAE) consensus motif; other site 1064551008784 putative AMP binding site [chemical binding]; other site 1064551008785 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 1064551008786 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1064551008787 DNA binding site [nucleotide binding] 1064551008788 domain linker motif; other site 1064551008789 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1064551008790 dimerization interface (closed form) [polypeptide binding]; other site 1064551008791 ligand binding site [chemical binding]; other site 1064551008792 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1064551008793 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1064551008794 DNA binding site [nucleotide binding] 1064551008795 domain linker motif; other site 1064551008796 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1064551008797 dimerization interface (closed form) [polypeptide binding]; other site 1064551008798 ligand binding site [chemical binding]; other site 1064551008799 diaminopimelate decarboxylase; Provisional; Region: PRK11165 1064551008800 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1064551008801 active site 1064551008802 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1064551008803 substrate binding site [chemical binding]; other site 1064551008804 catalytic residues [active] 1064551008805 dimer interface [polypeptide binding]; other site 1064551008806 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1064551008807 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551008808 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1064551008809 dimerization interface [polypeptide binding]; other site 1064551008810 putative racemase; Provisional; Region: PRK10200 1064551008811 aspartate racemase; Region: asp_race; TIGR00035 1064551008812 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1064551008813 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551008814 putative substrate translocation pore; other site 1064551008815 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551008816 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 1064551008817 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1064551008818 NADP binding site [chemical binding]; other site 1064551008819 homodimer interface [polypeptide binding]; other site 1064551008820 active site 1064551008821 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1064551008822 putative acyltransferase; Provisional; Region: PRK05790 1064551008823 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1064551008824 dimer interface [polypeptide binding]; other site 1064551008825 active site 1064551008826 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064551008827 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551008828 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1064551008829 dimerization interface [polypeptide binding]; other site 1064551008830 Predicted membrane protein [Function unknown]; Region: COG4125 1064551008831 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1064551008832 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1064551008833 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1064551008834 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1064551008835 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1064551008836 putative metal binding site [ion binding]; other site 1064551008837 putative homodimer interface [polypeptide binding]; other site 1064551008838 putative homotetramer interface [polypeptide binding]; other site 1064551008839 putative homodimer-homodimer interface [polypeptide binding]; other site 1064551008840 putative allosteric switch controlling residues; other site 1064551008841 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 1064551008842 transcriptional activator SprB; Provisional; Region: PRK15320 1064551008843 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14600 1064551008844 Protein of unknown function (DUF1401); Region: DUF1401; pfam07180 1064551008845 Fimbrial protein; Region: Fimbrial; pfam00419 1064551008846 fimbrial chaperone protein StdC; Provisional; Region: PRK15254 1064551008847 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1064551008848 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1064551008849 fimbrial outer membrane usher protein StdB; Provisional; Region: PRK15255 1064551008850 PapC N-terminal domain; Region: PapC_N; pfam13954 1064551008851 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1064551008852 PapC C-terminal domain; Region: PapC_C; pfam13953 1064551008853 fimbrial protein StdA; Provisional; Region: PRK15210 1064551008854 hypothetical protein; Provisional; Region: PRK10316 1064551008855 YfdX protein; Region: YfdX; pfam10938 1064551008856 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1064551008857 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1064551008858 oligomeric interface; other site 1064551008859 putative active site [active] 1064551008860 homodimer interface [polypeptide binding]; other site 1064551008861 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 1064551008862 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1064551008863 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 1064551008864 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1064551008865 Peptidase family M23; Region: Peptidase_M23; pfam01551 1064551008866 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1064551008867 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1064551008868 active site 1064551008869 metal binding site [ion binding]; metal-binding site 1064551008870 nudix motif; other site 1064551008871 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 1064551008872 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1064551008873 dimer interface [polypeptide binding]; other site 1064551008874 putative anticodon binding site; other site 1064551008875 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1064551008876 motif 1; other site 1064551008877 active site 1064551008878 motif 2; other site 1064551008879 motif 3; other site 1064551008880 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1064551008881 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1064551008882 RF-1 domain; Region: RF-1; pfam00472 1064551008883 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1064551008884 DHH family; Region: DHH; pfam01368 1064551008885 DHHA1 domain; Region: DHHA1; pfam02272 1064551008886 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 1064551008887 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1064551008888 dimerization domain [polypeptide binding]; other site 1064551008889 dimer interface [polypeptide binding]; other site 1064551008890 catalytic residues [active] 1064551008891 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1064551008892 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1064551008893 active site 1064551008894 Int/Topo IB signature motif; other site 1064551008895 flavodoxin FldB; Provisional; Region: PRK12359 1064551008896 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 1064551008897 hypothetical protein; Provisional; Region: PRK10878 1064551008898 putative global regulator; Reviewed; Region: PRK09559 1064551008899 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1064551008900 hemolysin; Provisional; Region: PRK15087 1064551008901 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1064551008902 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 1064551008903 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 1064551008904 beta-galactosidase; Region: BGL; TIGR03356 1064551008905 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 1064551008906 glycine dehydrogenase; Provisional; Region: PRK05367 1064551008907 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1064551008908 tetramer interface [polypeptide binding]; other site 1064551008909 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551008910 catalytic residue [active] 1064551008911 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1064551008912 tetramer interface [polypeptide binding]; other site 1064551008913 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551008914 catalytic residue [active] 1064551008915 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1064551008916 lipoyl attachment site [posttranslational modification]; other site 1064551008917 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1064551008918 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1064551008919 oxidoreductase; Provisional; Region: PRK08013 1064551008920 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1064551008921 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 1064551008922 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1064551008923 proline aminopeptidase P II; Provisional; Region: PRK10879 1064551008924 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1064551008925 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1064551008926 active site 1064551008927 hypothetical protein; Reviewed; Region: PRK01736 1064551008928 Z-ring-associated protein; Provisional; Region: PRK10972 1064551008929 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 1064551008930 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1064551008931 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1064551008932 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1064551008933 ligand binding site [chemical binding]; other site 1064551008934 NAD binding site [chemical binding]; other site 1064551008935 tetramer interface [polypeptide binding]; other site 1064551008936 catalytic site [active] 1064551008937 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1064551008938 L-serine binding site [chemical binding]; other site 1064551008939 ACT domain interface; other site 1064551008940 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1064551008941 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1064551008942 active site 1064551008943 dimer interface [polypeptide binding]; other site 1064551008944 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1064551008945 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551008946 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 1064551008947 putative dimerization interface [polypeptide binding]; other site 1064551008948 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1064551008949 oxidative stress defense protein; Provisional; Region: PRK11087 1064551008950 arginine exporter protein; Provisional; Region: PRK09304 1064551008951 mechanosensitive channel MscS; Provisional; Region: PRK10334 1064551008952 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1064551008953 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1064551008954 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 1064551008955 active site 1064551008956 intersubunit interface [polypeptide binding]; other site 1064551008957 zinc binding site [ion binding]; other site 1064551008958 Na+ binding site [ion binding]; other site 1064551008959 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1064551008960 Phosphoglycerate kinase; Region: PGK; pfam00162 1064551008961 substrate binding site [chemical binding]; other site 1064551008962 hinge regions; other site 1064551008963 ADP binding site [chemical binding]; other site 1064551008964 catalytic site [active] 1064551008965 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 1064551008966 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1064551008967 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1064551008968 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 1064551008969 trimer interface [polypeptide binding]; other site 1064551008970 putative Zn binding site [ion binding]; other site 1064551008971 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1064551008972 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1064551008973 Walker A/P-loop; other site 1064551008974 ATP binding site [chemical binding]; other site 1064551008975 ABC transporter; Region: ABC_tran; pfam00005 1064551008976 Q-loop/lid; other site 1064551008977 ABC transporter signature motif; other site 1064551008978 Walker B; other site 1064551008979 D-loop; other site 1064551008980 H-loop/switch region; other site 1064551008981 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1064551008982 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1064551008983 Walker A/P-loop; other site 1064551008984 ATP binding site [chemical binding]; other site 1064551008985 Q-loop/lid; other site 1064551008986 ABC transporter signature motif; other site 1064551008987 Walker B; other site 1064551008988 D-loop; other site 1064551008989 H-loop/switch region; other site 1064551008990 transketolase; Reviewed; Region: PRK12753 1064551008991 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1064551008992 TPP-binding site [chemical binding]; other site 1064551008993 dimer interface [polypeptide binding]; other site 1064551008994 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1064551008995 PYR/PP interface [polypeptide binding]; other site 1064551008996 dimer interface [polypeptide binding]; other site 1064551008997 TPP binding site [chemical binding]; other site 1064551008998 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1064551008999 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1064551009000 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1064551009001 agmatinase; Region: agmatinase; TIGR01230 1064551009002 oligomer interface [polypeptide binding]; other site 1064551009003 putative active site [active] 1064551009004 Mn binding site [ion binding]; other site 1064551009005 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1064551009006 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1064551009007 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 1064551009008 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1064551009009 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1064551009010 putative NAD(P) binding site [chemical binding]; other site 1064551009011 catalytic Zn binding site [ion binding]; other site 1064551009012 structural Zn binding site [ion binding]; other site 1064551009013 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1064551009014 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1064551009015 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1064551009016 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1064551009017 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1064551009018 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064551009019 DNA-binding site [nucleotide binding]; DNA binding site 1064551009020 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1064551009021 DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237 1064551009022 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 1064551009023 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1064551009024 dimer interface [polypeptide binding]; other site 1064551009025 active site 1064551009026 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1064551009027 catalytic residues [active] 1064551009028 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1064551009029 Virulence promoting factor; Region: YqgB; pfam11036 1064551009030 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1064551009031 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1064551009032 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1064551009033 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1064551009034 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1064551009035 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551009036 putative substrate translocation pore; other site 1064551009037 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551009038 hypothetical protein; Provisional; Region: PRK04860 1064551009039 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1064551009040 DNA-specific endonuclease I; Provisional; Region: PRK15137 1064551009041 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 1064551009042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1064551009043 RNA methyltransferase, RsmE family; Region: TIGR00046 1064551009044 glutathione synthetase; Provisional; Region: PRK05246 1064551009045 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1064551009046 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1064551009047 hypothetical protein; Validated; Region: PRK00228 1064551009048 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1064551009049 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1064551009050 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1064551009051 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1064551009052 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1064551009053 Walker A motif; other site 1064551009054 ATP binding site [chemical binding]; other site 1064551009055 Walker B motif; other site 1064551009056 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 1064551009057 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1064551009058 catalytic residue [active] 1064551009059 YGGT family; Region: YGGT; pfam02325 1064551009060 YGGT family; Region: YGGT; pfam02325 1064551009061 hypothetical protein; Validated; Region: PRK05090 1064551009062 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1064551009063 active site 1064551009064 dimerization interface [polypeptide binding]; other site 1064551009065 HemN family oxidoreductase; Provisional; Region: PRK05660 1064551009066 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064551009067 FeS/SAM binding site; other site 1064551009068 HemN C-terminal domain; Region: HemN_C; pfam06969 1064551009069 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 1064551009070 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 1064551009071 homodimer interface [polypeptide binding]; other site 1064551009072 active site 1064551009073 hypothetical protein; Provisional; Region: PRK10626 1064551009074 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 1064551009075 hypothetical protein; Provisional; Region: PRK11702 1064551009076 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1064551009077 adenine DNA glycosylase; Provisional; Region: PRK10880 1064551009078 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1064551009079 minor groove reading motif; other site 1064551009080 helix-hairpin-helix signature motif; other site 1064551009081 substrate binding pocket [chemical binding]; other site 1064551009082 active site 1064551009083 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1064551009084 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1064551009085 DNA binding and oxoG recognition site [nucleotide binding] 1064551009086 oxidative damage protection protein; Provisional; Region: PRK05408 1064551009087 murein transglycosylase C; Provisional; Region: mltC; PRK11671 1064551009088 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 1064551009089 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1064551009090 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1064551009091 catalytic residue [active] 1064551009092 nucleoside transporter; Region: 2A0110; TIGR00889 1064551009093 ornithine decarboxylase; Provisional; Region: PRK13578 1064551009094 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1064551009095 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1064551009096 homodimer interface [polypeptide binding]; other site 1064551009097 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551009098 catalytic residue [active] 1064551009099 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1064551009100 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 1064551009101 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 1064551009102 dimer interface [polypeptide binding]; other site 1064551009103 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1064551009104 metal binding site [ion binding]; metal-binding site 1064551009105 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 1064551009106 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1064551009107 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1064551009108 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1064551009109 putative active site [active] 1064551009110 putative catalytic site [active] 1064551009111 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1064551009112 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1064551009113 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551009114 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 1064551009115 putative dimerization interface [polypeptide binding]; other site 1064551009116 putative substrate binding pocket [chemical binding]; other site 1064551009117 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1064551009118 Sulfatase; Region: Sulfatase; pfam00884 1064551009119 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1064551009120 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064551009121 FeS/SAM binding site; other site 1064551009122 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1064551009123 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1064551009124 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064551009125 DNA binding residues [nucleotide binding] 1064551009126 dimerization interface [polypeptide binding]; other site 1064551009127 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 1064551009128 Amino acid permease; Region: AA_permease_2; pfam13520 1064551009129 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 1064551009130 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1064551009131 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1064551009132 Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113 1064551009133 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1064551009134 NAD(P) binding site [chemical binding]; other site 1064551009135 catalytic residues [active] 1064551009136 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 1064551009137 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 1064551009138 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 1064551009139 active site 1064551009140 catalytic site [active] 1064551009141 Zn binding site [ion binding]; other site 1064551009142 tetramer interface [polypeptide binding]; other site 1064551009143 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1064551009144 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 1064551009145 putative active site [active] 1064551009146 catalytic triad [active] 1064551009147 putative dimer interface [polypeptide binding]; other site 1064551009148 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551009149 D-galactonate transporter; Region: 2A0114; TIGR00893 1064551009150 putative substrate translocation pore; other site 1064551009151 mannonate dehydratase; Provisional; Region: PRK03906 1064551009152 mannonate dehydratase; Region: uxuA; TIGR00695 1064551009153 D-mannonate oxidoreductase; Provisional; Region: PRK15037 1064551009154 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1064551009155 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1064551009156 Glucuronate isomerase; Region: UxaC; pfam02614 1064551009157 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1064551009158 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064551009159 dimer interface [polypeptide binding]; other site 1064551009160 putative CheW interface [polypeptide binding]; other site 1064551009161 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 1064551009162 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 1064551009163 CHAP domain; Region: CHAP; pfam05257 1064551009164 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1064551009165 putative S-transferase; Provisional; Region: PRK11752 1064551009166 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1064551009167 C-terminal domain interface [polypeptide binding]; other site 1064551009168 GSH binding site (G-site) [chemical binding]; other site 1064551009169 dimer interface [polypeptide binding]; other site 1064551009170 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 1064551009171 dimer interface [polypeptide binding]; other site 1064551009172 N-terminal domain interface [polypeptide binding]; other site 1064551009173 active site 1064551009174 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1064551009175 molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537 1064551009176 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 1064551009177 putative ligand binding residues [chemical binding]; other site 1064551009178 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1064551009179 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 1064551009180 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 1064551009181 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 1064551009182 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 1064551009183 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 1064551009184 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1064551009185 putative substrate-binding site; other site 1064551009186 nickel binding site [ion binding]; other site 1064551009187 hydrogenase 2 large subunit; Provisional; Region: PRK10467 1064551009188 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1064551009189 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 1064551009190 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1064551009191 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 1064551009192 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1064551009193 hydrogenase 2 small subunit; Provisional; Region: PRK10468 1064551009194 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1064551009195 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1064551009196 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 1064551009197 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 1064551009198 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064551009199 dimerization interface [polypeptide binding]; other site 1064551009200 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064551009201 dimer interface [polypeptide binding]; other site 1064551009202 putative CheW interface [polypeptide binding]; other site 1064551009203 hypothetical protein; Provisional; Region: PRK05208 1064551009204 oxidoreductase; Provisional; Region: PRK07985 1064551009205 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1064551009206 NAD binding site [chemical binding]; other site 1064551009207 metal binding site [ion binding]; metal-binding site 1064551009208 active site 1064551009209 biopolymer transport protein ExbD; Provisional; Region: PRK11267 1064551009210 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1064551009211 biopolymer transport protein ExbB; Provisional; Region: PRK10414 1064551009212 cystathionine beta-lyase; Provisional; Region: PRK08114 1064551009213 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1064551009214 homodimer interface [polypeptide binding]; other site 1064551009215 substrate-cofactor binding pocket; other site 1064551009216 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551009217 catalytic residue [active] 1064551009218 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1064551009219 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1064551009220 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1064551009221 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1064551009222 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064551009223 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064551009224 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1064551009225 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1064551009226 dimer interface [polypeptide binding]; other site 1064551009227 active site 1064551009228 metal binding site [ion binding]; metal-binding site 1064551009229 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1064551009230 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1064551009231 active site 1064551009232 catalytic tetrad [active] 1064551009233 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1064551009234 nucleotide binding site/active site [active] 1064551009235 catalytic residue [active] 1064551009236 hypothetical protein; Provisional; Region: PRK01254 1064551009237 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 1064551009238 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 1064551009239 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1064551009240 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1064551009241 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1064551009242 DctM-like transporters; Region: DctM; pfam06808 1064551009243 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 1064551009244 FtsI repressor; Provisional; Region: PRK10883 1064551009245 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1064551009246 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1064551009247 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 1064551009248 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1064551009249 putative acyl-acceptor binding pocket; other site 1064551009250 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 1064551009251 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1064551009252 CAP-like domain; other site 1064551009253 active site 1064551009254 primary dimer interface [polypeptide binding]; other site 1064551009255 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1064551009256 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064551009257 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 1064551009258 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 1064551009259 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 1064551009260 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064551009261 active site 1064551009262 phosphorylation site [posttranslational modification] 1064551009263 intermolecular recognition site; other site 1064551009264 dimerization interface [polypeptide binding]; other site 1064551009265 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1064551009266 DNA binding site [nucleotide binding] 1064551009267 sensor protein QseC; Provisional; Region: PRK10337 1064551009268 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 1064551009269 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064551009270 dimer interface [polypeptide binding]; other site 1064551009271 phosphorylation site [posttranslational modification] 1064551009272 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064551009273 ATP binding site [chemical binding]; other site 1064551009274 Mg2+ binding site [ion binding]; other site 1064551009275 G-X-G motif; other site 1064551009276 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1064551009277 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1064551009278 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 1064551009279 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064551009280 ATP binding site [chemical binding]; other site 1064551009281 Mg2+ binding site [ion binding]; other site 1064551009282 G-X-G motif; other site 1064551009283 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1064551009284 anchoring element; other site 1064551009285 dimer interface [polypeptide binding]; other site 1064551009286 ATP binding site [chemical binding]; other site 1064551009287 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1064551009288 active site 1064551009289 metal binding site [ion binding]; metal-binding site 1064551009290 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1064551009291 esterase YqiA; Provisional; Region: PRK11071 1064551009292 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1064551009293 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1064551009294 active site 1064551009295 metal binding site [ion binding]; metal-binding site 1064551009296 hexamer interface [polypeptide binding]; other site 1064551009297 putative dehydrogenase; Provisional; Region: PRK11039 1064551009298 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1064551009299 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1064551009300 dimer interface [polypeptide binding]; other site 1064551009301 ADP-ribose binding site [chemical binding]; other site 1064551009302 active site 1064551009303 nudix motif; other site 1064551009304 metal binding site [ion binding]; metal-binding site 1064551009305 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 1064551009306 hypothetical protein; Provisional; Region: PRK11653 1064551009307 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1064551009308 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1064551009309 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1064551009310 putative active site [active] 1064551009311 metal binding site [ion binding]; metal-binding site 1064551009312 zinc transporter ZupT; Provisional; Region: PRK04201 1064551009313 ZIP Zinc transporter; Region: Zip; pfam02535 1064551009314 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 1064551009315 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 1064551009316 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1064551009317 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1064551009318 catalytic residues [active] 1064551009319 hinge region; other site 1064551009320 alpha helical domain; other site 1064551009321 putative disulfide oxidoreductase; Provisional; Region: PRK04307 1064551009322 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 1064551009323 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1064551009324 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 1064551009325 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 1064551009326 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 1064551009327 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1064551009328 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1064551009329 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 1064551009330 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1064551009331 putative ribose interaction site [chemical binding]; other site 1064551009332 putative ADP binding site [chemical binding]; other site 1064551009333 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1064551009334 active site 1064551009335 nucleotide binding site [chemical binding]; other site 1064551009336 HIGH motif; other site 1064551009337 KMSKS motif; other site 1064551009338 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1064551009339 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1064551009340 metal binding triad; other site 1064551009341 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1064551009342 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1064551009343 metal binding triad; other site 1064551009344 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1064551009345 Uncharacterized conserved protein [Function unknown]; Region: COG3025 1064551009346 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1064551009347 putative active site [active] 1064551009348 putative metal binding residues [ion binding]; other site 1064551009349 signature motif; other site 1064551009350 putative triphosphate binding site [ion binding]; other site 1064551009351 CHAD domain; Region: CHAD; pfam05235 1064551009352 SH3 domain-containing protein; Provisional; Region: PRK10884 1064551009353 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1064551009354 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1064551009355 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1064551009356 active site 1064551009357 NTP binding site [chemical binding]; other site 1064551009358 metal binding triad [ion binding]; metal-binding site 1064551009359 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1064551009360 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1064551009361 Zn2+ binding site [ion binding]; other site 1064551009362 Mg2+ binding site [ion binding]; other site 1064551009363 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1064551009364 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1064551009365 homooctamer interface [polypeptide binding]; other site 1064551009366 active site 1064551009367 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1064551009368 UGMP family protein; Validated; Region: PRK09604 1064551009369 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1064551009370 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1064551009371 DNA primase; Validated; Region: dnaG; PRK05667 1064551009372 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1064551009373 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1064551009374 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1064551009375 active site 1064551009376 metal binding site [ion binding]; metal-binding site 1064551009377 interdomain interaction site; other site 1064551009378 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1064551009379 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 1064551009380 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1064551009381 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1064551009382 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1064551009383 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1064551009384 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1064551009385 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1064551009386 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1064551009387 DNA binding residues [nucleotide binding] 1064551009388 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1064551009389 active site 1064551009390 SUMO-1 interface [polypeptide binding]; other site 1064551009391 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1064551009392 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1064551009393 FAD binding pocket [chemical binding]; other site 1064551009394 FAD binding motif [chemical binding]; other site 1064551009395 phosphate binding motif [ion binding]; other site 1064551009396 NAD binding pocket [chemical binding]; other site 1064551009397 Predicted transcriptional regulators [Transcription]; Region: COG1695 1064551009398 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1064551009399 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1064551009400 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064551009401 dimerization interface [polypeptide binding]; other site 1064551009402 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1064551009403 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064551009404 dimer interface [polypeptide binding]; other site 1064551009405 putative CheW interface [polypeptide binding]; other site 1064551009406 PAS fold; Region: PAS_3; pfam08447 1064551009407 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064551009408 putative active site [active] 1064551009409 heme pocket [chemical binding]; other site 1064551009410 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1064551009411 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064551009412 dimer interface [polypeptide binding]; other site 1064551009413 putative CheW interface [polypeptide binding]; other site 1064551009414 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 1064551009415 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1064551009416 inhibitor-cofactor binding pocket; inhibition site 1064551009417 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551009418 catalytic residue [active] 1064551009419 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1064551009420 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1064551009421 active site 1064551009422 FMN binding site [chemical binding]; other site 1064551009423 2,4-decadienoyl-CoA binding site; other site 1064551009424 catalytic residue [active] 1064551009425 4Fe-4S cluster binding site [ion binding]; other site 1064551009426 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1064551009427 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1064551009428 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 1064551009429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064551009430 S-adenosylmethionine binding site [chemical binding]; other site 1064551009431 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 1064551009432 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1064551009433 putative active site [active] 1064551009434 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1064551009435 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1064551009436 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1064551009437 serine/threonine transporter SstT; Provisional; Region: PRK13628 1064551009438 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1064551009439 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1064551009440 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1064551009441 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 1064551009442 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 1064551009443 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 1064551009444 Predicted membrane protein [Function unknown]; Region: COG5393 1064551009445 YqjK-like protein; Region: YqjK; pfam13997 1064551009446 Predicted membrane protein [Function unknown]; Region: COG2259 1064551009447 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1064551009448 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1064551009449 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1064551009450 putative dimer interface [polypeptide binding]; other site 1064551009451 N-terminal domain interface [polypeptide binding]; other site 1064551009452 putative substrate binding pocket (H-site) [chemical binding]; other site 1064551009453 Predicted membrane protein [Function unknown]; Region: COG3152 1064551009454 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551009455 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1064551009456 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1064551009457 dimerization interface [polypeptide binding]; other site 1064551009458 Pirin-related protein [General function prediction only]; Region: COG1741 1064551009459 Pirin; Region: Pirin; pfam02678 1064551009460 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 1064551009461 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1064551009462 serine transporter; Region: stp; TIGR00814 1064551009463 L-serine dehydratase TdcG; Provisional; Region: PRK15040 1064551009464 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1064551009465 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1064551009466 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1064551009467 Pyruvate formate lyase 1; Region: PFL1; cd01678 1064551009468 coenzyme A binding site [chemical binding]; other site 1064551009469 active site 1064551009470 catalytic residues [active] 1064551009471 glycine loop; other site 1064551009472 propionate/acetate kinase; Provisional; Region: PRK12379 1064551009473 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 1064551009474 threonine/serine transporter TdcC; Provisional; Region: PRK13629 1064551009475 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1064551009476 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1064551009477 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1064551009478 tetramer interface [polypeptide binding]; other site 1064551009479 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551009480 catalytic residue [active] 1064551009481 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 1064551009482 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551009483 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 1064551009484 putative substrate binding pocket [chemical binding]; other site 1064551009485 putative dimerization interface [polypeptide binding]; other site 1064551009486 glycerate kinase I; Provisional; Region: PRK10342 1064551009487 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 1064551009488 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1064551009489 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 1064551009490 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1064551009491 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1064551009492 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1064551009493 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1064551009494 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1064551009495 substrate binding site [chemical binding]; other site 1064551009496 ATP binding site [chemical binding]; other site 1064551009497 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1064551009498 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1064551009499 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1064551009500 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1064551009501 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1064551009502 intersubunit interface [polypeptide binding]; other site 1064551009503 active site 1064551009504 zinc binding site [ion binding]; other site 1064551009505 Na+ binding site [ion binding]; other site 1064551009506 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1064551009507 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1064551009508 putative substrate binding site [chemical binding]; other site 1064551009509 putative ATP binding site [chemical binding]; other site 1064551009510 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1064551009511 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1064551009512 active site 1064551009513 P-loop; other site 1064551009514 phosphorylation site [posttranslational modification] 1064551009515 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1064551009516 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1064551009517 active site 1064551009518 phosphorylation site [posttranslational modification] 1064551009519 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1064551009520 dimerization domain swap beta strand [polypeptide binding]; other site 1064551009521 regulatory protein interface [polypeptide binding]; other site 1064551009522 active site 1064551009523 regulatory phosphorylation site [posttranslational modification]; other site 1064551009524 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 1064551009525 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1064551009526 active site 1064551009527 phosphorylation site [posttranslational modification] 1064551009528 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1064551009529 active site 1064551009530 P-loop; other site 1064551009531 phosphorylation site [posttranslational modification] 1064551009532 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1064551009533 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1064551009534 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 1064551009535 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 1064551009536 putative NAD(P) binding site [chemical binding]; other site 1064551009537 catalytic Zn binding site [ion binding]; other site 1064551009538 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1064551009539 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1064551009540 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1064551009541 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 1064551009542 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1064551009543 putative SAM binding site [chemical binding]; other site 1064551009544 putative homodimer interface [polypeptide binding]; other site 1064551009545 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1064551009546 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 1064551009547 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1064551009548 putative ligand binding site [chemical binding]; other site 1064551009549 TIGR00252 family protein; Region: TIGR00252 1064551009550 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1064551009551 dimer interface [polypeptide binding]; other site 1064551009552 active site 1064551009553 outer membrane lipoprotein; Provisional; Region: PRK11023 1064551009554 BON domain; Region: BON; pfam04972 1064551009555 BON domain; Region: BON; pfam04972 1064551009556 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 1064551009557 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1064551009558 NAD binding site [chemical binding]; other site 1064551009559 active site 1064551009560 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1064551009561 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1064551009562 proposed catalytic triad [active] 1064551009563 conserved cys residue [active] 1064551009564 hypothetical protein; Provisional; Region: PRK03467 1064551009565 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1064551009566 GIY-YIG motif/motif A; other site 1064551009567 putative active site [active] 1064551009568 putative metal binding site [ion binding]; other site 1064551009569 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1064551009570 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064551009571 Coenzyme A binding pocket [chemical binding]; other site 1064551009572 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 1064551009573 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1064551009574 Peptidase family U32; Region: Peptidase_U32; pfam01136 1064551009575 putative protease; Provisional; Region: PRK15447 1064551009576 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1064551009577 hypothetical protein; Provisional; Region: PRK10508 1064551009578 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1064551009579 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1064551009580 tryptophan permease; Provisional; Region: PRK10483 1064551009581 aromatic amino acid transport protein; Region: araaP; TIGR00837 1064551009582 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1064551009583 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1064551009584 ATP binding site [chemical binding]; other site 1064551009585 Mg++ binding site [ion binding]; other site 1064551009586 motif III; other site 1064551009587 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1064551009588 nucleotide binding region [chemical binding]; other site 1064551009589 ATP-binding site [chemical binding]; other site 1064551009590 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1064551009591 putative RNA binding site [nucleotide binding]; other site 1064551009592 lipoprotein NlpI; Provisional; Region: PRK11189 1064551009593 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064551009594 binding surface 1064551009595 TPR motif; other site 1064551009596 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1064551009597 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1064551009598 RNase E interface [polypeptide binding]; other site 1064551009599 trimer interface [polypeptide binding]; other site 1064551009600 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1064551009601 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1064551009602 RNase E interface [polypeptide binding]; other site 1064551009603 trimer interface [polypeptide binding]; other site 1064551009604 active site 1064551009605 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1064551009606 putative nucleic acid binding region [nucleotide binding]; other site 1064551009607 G-X-X-G motif; other site 1064551009608 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1064551009609 RNA binding site [nucleotide binding]; other site 1064551009610 domain interface; other site 1064551009611 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1064551009612 16S/18S rRNA binding site [nucleotide binding]; other site 1064551009613 S13e-L30e interaction site [polypeptide binding]; other site 1064551009614 25S rRNA binding site [nucleotide binding]; other site 1064551009615 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1064551009616 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1064551009617 RNA binding site [nucleotide binding]; other site 1064551009618 active site 1064551009619 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1064551009620 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1064551009621 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1064551009622 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1064551009623 translation initiation factor IF-2; Region: IF-2; TIGR00487 1064551009624 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1064551009625 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1064551009626 G1 box; other site 1064551009627 putative GEF interaction site [polypeptide binding]; other site 1064551009628 GTP/Mg2+ binding site [chemical binding]; other site 1064551009629 Switch I region; other site 1064551009630 G2 box; other site 1064551009631 G3 box; other site 1064551009632 Switch II region; other site 1064551009633 G4 box; other site 1064551009634 G5 box; other site 1064551009635 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1064551009636 Translation-initiation factor 2; Region: IF-2; pfam11987 1064551009637 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1064551009638 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1064551009639 NusA N-terminal domain; Region: NusA_N; pfam08529 1064551009640 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1064551009641 RNA binding site [nucleotide binding]; other site 1064551009642 homodimer interface [polypeptide binding]; other site 1064551009643 NusA-like KH domain; Region: KH_5; pfam13184 1064551009644 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1064551009645 G-X-X-G motif; other site 1064551009646 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1064551009647 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1064551009648 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1064551009649 Sm and related proteins; Region: Sm_like; cl00259 1064551009650 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1064551009651 putative oligomer interface [polypeptide binding]; other site 1064551009652 putative RNA binding site [nucleotide binding]; other site 1064551009653 argininosuccinate synthase; Validated; Region: PRK05370 1064551009654 argininosuccinate synthase; Provisional; Region: PRK13820 1064551009655 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1064551009656 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1064551009657 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1064551009658 active site 1064551009659 substrate binding site [chemical binding]; other site 1064551009660 metal binding site [ion binding]; metal-binding site 1064551009661 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1064551009662 dihydropteroate synthase; Region: DHPS; TIGR01496 1064551009663 substrate binding pocket [chemical binding]; other site 1064551009664 dimer interface [polypeptide binding]; other site 1064551009665 inhibitor binding site; inhibition site 1064551009666 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 1064551009667 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064551009668 Walker A motif; other site 1064551009669 ATP binding site [chemical binding]; other site 1064551009670 Walker B motif; other site 1064551009671 arginine finger; other site 1064551009672 Peptidase family M41; Region: Peptidase_M41; pfam01434 1064551009673 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1064551009674 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064551009675 S-adenosylmethionine binding site [chemical binding]; other site 1064551009676 RNA-binding protein YhbY; Provisional; Region: PRK10343 1064551009677 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1064551009678 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1064551009679 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1064551009680 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 1064551009681 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1064551009682 GTPase CgtA; Reviewed; Region: obgE; PRK12298 1064551009683 GTP1/OBG; Region: GTP1_OBG; pfam01018 1064551009684 Obg GTPase; Region: Obg; cd01898 1064551009685 G1 box; other site 1064551009686 GTP/Mg2+ binding site [chemical binding]; other site 1064551009687 Switch I region; other site 1064551009688 G2 box; other site 1064551009689 G3 box; other site 1064551009690 Switch II region; other site 1064551009691 G4 box; other site 1064551009692 G5 box; other site 1064551009693 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1064551009694 EamA-like transporter family; Region: EamA; pfam00892 1064551009695 EamA-like transporter family; Region: EamA; pfam00892 1064551009696 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1064551009697 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1064551009698 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1064551009699 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1064551009700 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1064551009701 substrate binding pocket [chemical binding]; other site 1064551009702 chain length determination region; other site 1064551009703 substrate-Mg2+ binding site; other site 1064551009704 catalytic residues [active] 1064551009705 aspartate-rich region 1; other site 1064551009706 active site lid residues [active] 1064551009707 aspartate-rich region 2; other site 1064551009708 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 1064551009709 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1064551009710 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1064551009711 hinge; other site 1064551009712 active site 1064551009713 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 1064551009714 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1064551009715 anti sigma factor interaction site; other site 1064551009716 regulatory phosphorylation site [posttranslational modification]; other site 1064551009717 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 1064551009718 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1064551009719 mce related protein; Region: MCE; pfam02470 1064551009720 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1064551009721 conserved hypothetical integral membrane protein; Region: TIGR00056 1064551009722 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 1064551009723 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1064551009724 Walker A/P-loop; other site 1064551009725 ATP binding site [chemical binding]; other site 1064551009726 Q-loop/lid; other site 1064551009727 ABC transporter signature motif; other site 1064551009728 Walker B; other site 1064551009729 D-loop; other site 1064551009730 H-loop/switch region; other site 1064551009731 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 1064551009732 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1064551009733 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1064551009734 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1064551009735 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1064551009736 putative active site [active] 1064551009737 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1064551009738 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 1064551009739 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1064551009740 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 1064551009741 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1064551009742 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 1064551009743 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1064551009744 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 1064551009745 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1064551009746 Walker A/P-loop; other site 1064551009747 ATP binding site [chemical binding]; other site 1064551009748 Q-loop/lid; other site 1064551009749 ABC transporter signature motif; other site 1064551009750 Walker B; other site 1064551009751 D-loop; other site 1064551009752 H-loop/switch region; other site 1064551009753 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1064551009754 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1064551009755 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1064551009756 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1064551009757 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1064551009758 30S subunit binding site; other site 1064551009759 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1064551009760 active site 1064551009761 phosphorylation site [posttranslational modification] 1064551009762 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 1064551009763 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1064551009764 dimerization domain swap beta strand [polypeptide binding]; other site 1064551009765 regulatory protein interface [polypeptide binding]; other site 1064551009766 active site 1064551009767 regulatory phosphorylation site [posttranslational modification]; other site 1064551009768 hypothetical protein; Provisional; Region: PRK10345 1064551009769 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1064551009770 Transglycosylase; Region: Transgly; cl17702 1064551009771 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 1064551009772 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 1064551009773 conserved cys residue [active] 1064551009774 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 1064551009775 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064551009776 putative active site [active] 1064551009777 heme pocket [chemical binding]; other site 1064551009778 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064551009779 dimer interface [polypeptide binding]; other site 1064551009780 phosphorylation site [posttranslational modification] 1064551009781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064551009782 ATP binding site [chemical binding]; other site 1064551009783 Mg2+ binding site [ion binding]; other site 1064551009784 G-X-G motif; other site 1064551009785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064551009786 active site 1064551009787 phosphorylation site [posttranslational modification] 1064551009788 intermolecular recognition site; other site 1064551009789 dimerization interface [polypeptide binding]; other site 1064551009790 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1064551009791 putative binding surface; other site 1064551009792 active site 1064551009793 radical SAM protein, TIGR01212 family; Region: TIGR01212 1064551009794 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064551009795 FeS/SAM binding site; other site 1064551009796 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1064551009797 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1064551009798 active site 1064551009799 dimer interface [polypeptide binding]; other site 1064551009800 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1064551009801 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1064551009802 active site 1064551009803 FMN binding site [chemical binding]; other site 1064551009804 substrate binding site [chemical binding]; other site 1064551009805 3Fe-4S cluster binding site [ion binding]; other site 1064551009806 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1064551009807 domain interface; other site 1064551009808 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 1064551009809 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1064551009810 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1064551009811 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 1064551009812 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 1064551009813 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 1064551009814 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1064551009815 Na binding site [ion binding]; other site 1064551009816 putative substrate binding site [chemical binding]; other site 1064551009817 cytosine deaminase; Provisional; Region: PRK09230 1064551009818 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1064551009819 active site 1064551009820 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1064551009821 N-acetylmannosamine kinase; Provisional; Region: PRK05082 1064551009822 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1064551009823 nucleotide binding site [chemical binding]; other site 1064551009824 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 1064551009825 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1064551009826 putative active site cavity [active] 1064551009827 putative sialic acid transporter; Provisional; Region: PRK03893 1064551009828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551009829 putative substrate translocation pore; other site 1064551009830 N-acetylneuraminate lyase; Provisional; Region: PRK04147 1064551009831 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 1064551009832 inhibitor site; inhibition site 1064551009833 active site 1064551009834 dimer interface [polypeptide binding]; other site 1064551009835 catalytic residue [active] 1064551009836 transcriptional regulator NanR; Provisional; Region: PRK03837 1064551009837 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064551009838 DNA-binding site [nucleotide binding]; DNA binding site 1064551009839 FCD domain; Region: FCD; pfam07729 1064551009840 Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969 1064551009841 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1064551009842 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 1064551009843 C-terminal domain interface [polypeptide binding]; other site 1064551009844 putative GSH binding site (G-site) [chemical binding]; other site 1064551009845 dimer interface [polypeptide binding]; other site 1064551009846 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1064551009847 dimer interface [polypeptide binding]; other site 1064551009848 N-terminal domain interface [polypeptide binding]; other site 1064551009849 Family of unknown function (DUF695); Region: DUF695; pfam05117 1064551009850 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 1064551009851 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1064551009852 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1064551009853 23S rRNA interface [nucleotide binding]; other site 1064551009854 L3 interface [polypeptide binding]; other site 1064551009855 Predicted ATPase [General function prediction only]; Region: COG1485 1064551009856 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 1064551009857 hypothetical protein; Provisional; Region: PRK11677 1064551009858 serine endoprotease; Provisional; Region: PRK10139 1064551009859 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1064551009860 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1064551009861 protein binding site [polypeptide binding]; other site 1064551009862 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1064551009863 serine endoprotease; Provisional; Region: PRK10898 1064551009864 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1064551009865 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1064551009866 Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767 1064551009867 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 1064551009868 oxaloacetate decarboxylase; Provisional; Region: PRK14040 1064551009869 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1064551009870 active site 1064551009871 catalytic residues [active] 1064551009872 metal binding site [ion binding]; metal-binding site 1064551009873 homodimer binding site [polypeptide binding]; other site 1064551009874 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1064551009875 carboxyltransferase (CT) interaction site; other site 1064551009876 biotinylation site [posttranslational modification]; other site 1064551009877 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 1064551009878 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 1064551009879 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 1064551009880 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1064551009881 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1064551009882 transmembrane helices; other site 1064551009883 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1064551009884 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064551009885 DNA-binding site [nucleotide binding]; DNA binding site 1064551009886 FCD domain; Region: FCD; pfam07729 1064551009887 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1064551009888 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064551009889 DNA-binding site [nucleotide binding]; DNA binding site 1064551009890 malate dehydrogenase; Provisional; Region: PRK05086 1064551009891 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 1064551009892 NAD binding site [chemical binding]; other site 1064551009893 dimerization interface [polypeptide binding]; other site 1064551009894 Substrate binding site [chemical binding]; other site 1064551009895 arginine repressor; Provisional; Region: PRK05066 1064551009896 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1064551009897 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1064551009898 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1064551009899 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1064551009900 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1064551009901 RNAase interaction site [polypeptide binding]; other site 1064551009902 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 1064551009903 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1064551009904 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 1064551009905 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1064551009906 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064551009907 efflux system membrane protein; Provisional; Region: PRK11594 1064551009908 transcriptional regulator; Provisional; Region: PRK10632 1064551009909 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551009910 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1064551009911 putative effector binding pocket; other site 1064551009912 dimerization interface [polypeptide binding]; other site 1064551009913 protease TldD; Provisional; Region: tldD; PRK10735 1064551009914 hypothetical protein; Provisional; Region: PRK10899 1064551009915 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1064551009916 ribonuclease G; Provisional; Region: PRK11712 1064551009917 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1064551009918 homodimer interface [polypeptide binding]; other site 1064551009919 oligonucleotide binding site [chemical binding]; other site 1064551009920 Maf-like protein; Region: Maf; pfam02545 1064551009921 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1064551009922 active site 1064551009923 dimer interface [polypeptide binding]; other site 1064551009924 rod shape-determining protein MreD; Provisional; Region: PRK11060 1064551009925 rod shape-determining protein MreC; Region: mreC; TIGR00219 1064551009926 rod shape-determining protein MreC; Region: MreC; pfam04085 1064551009927 rod shape-determining protein MreB; Provisional; Region: PRK13927 1064551009928 MreB and similar proteins; Region: MreB_like; cd10225 1064551009929 nucleotide binding site [chemical binding]; other site 1064551009930 Mg binding site [ion binding]; other site 1064551009931 putative protofilament interaction site [polypeptide binding]; other site 1064551009932 RodZ interaction site [polypeptide binding]; other site 1064551009933 regulatory protein CsrD; Provisional; Region: PRK11059 1064551009934 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064551009935 metal binding site [ion binding]; metal-binding site 1064551009936 active site 1064551009937 I-site; other site 1064551009938 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1064551009939 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1064551009940 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1064551009941 NADP binding site [chemical binding]; other site 1064551009942 dimer interface [polypeptide binding]; other site 1064551009943 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1064551009944 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 1064551009945 Moco binding site; other site 1064551009946 metal coordination site [ion binding]; other site 1064551009947 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1064551009948 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1064551009949 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1064551009950 carboxyltransferase (CT) interaction site; other site 1064551009951 biotinylation site [posttranslational modification]; other site 1064551009952 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1064551009953 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1064551009954 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1064551009955 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1064551009956 hypothetical protein; Provisional; Region: PRK10633 1064551009957 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 1064551009958 Na binding site [ion binding]; other site 1064551009959 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 1064551009960 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1064551009961 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 1064551009962 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1064551009963 FMN binding site [chemical binding]; other site 1064551009964 active site 1064551009965 catalytic residues [active] 1064551009966 substrate binding site [chemical binding]; other site 1064551009967 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 1064551009968 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 1064551009969 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1064551009970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064551009971 DNA methylase; Region: N6_N4_Mtase; pfam01555 1064551009972 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 1064551009973 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 1064551009974 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1064551009975 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1064551009976 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1064551009977 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1064551009978 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064551009979 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 1064551009980 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1064551009981 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1064551009982 trimer interface [polypeptide binding]; other site 1064551009983 putative metal binding site [ion binding]; other site 1064551009984 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 1064551009985 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1064551009986 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1064551009987 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1064551009988 shikimate binding site; other site 1064551009989 NAD(P) binding site [chemical binding]; other site 1064551009990 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 1064551009991 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1064551009992 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1064551009993 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1064551009994 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1064551009995 hypothetical protein; Validated; Region: PRK03430 1064551009996 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1064551009997 active site 1064551009998 catalytic residues [active] 1064551009999 metal binding site [ion binding]; metal-binding site 1064551010000 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1064551010001 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1064551010002 putative active site [active] 1064551010003 substrate binding site [chemical binding]; other site 1064551010004 putative cosubstrate binding site; other site 1064551010005 catalytic site [active] 1064551010006 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1064551010007 substrate binding site [chemical binding]; other site 1064551010008 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1064551010009 putative RNA binding site [nucleotide binding]; other site 1064551010010 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1064551010011 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064551010012 S-adenosylmethionine binding site [chemical binding]; other site 1064551010013 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1064551010014 TrkA-N domain; Region: TrkA_N; pfam02254 1064551010015 TrkA-C domain; Region: TrkA_C; pfam02080 1064551010016 TrkA-N domain; Region: TrkA_N; pfam02254 1064551010017 TrkA-C domain; Region: TrkA_C; pfam02080 1064551010018 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1064551010019 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1064551010020 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 1064551010021 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1064551010022 DNA binding residues [nucleotide binding] 1064551010023 dimer interface [polypeptide binding]; other site 1064551010024 metal binding site [ion binding]; metal-binding site 1064551010025 hypothetical protein; Provisional; Region: PRK10203 1064551010026 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1064551010027 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1064551010028 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1064551010029 alphaNTD homodimer interface [polypeptide binding]; other site 1064551010030 alphaNTD - beta interaction site [polypeptide binding]; other site 1064551010031 alphaNTD - beta' interaction site [polypeptide binding]; other site 1064551010032 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1064551010033 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1064551010034 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1064551010035 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1064551010036 RNA binding surface [nucleotide binding]; other site 1064551010037 30S ribosomal protein S11; Validated; Region: PRK05309 1064551010038 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1064551010039 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1064551010040 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1064551010041 SecY translocase; Region: SecY; pfam00344 1064551010042 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1064551010043 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1064551010044 23S rRNA binding site [nucleotide binding]; other site 1064551010045 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1064551010046 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1064551010047 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1064551010048 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1064551010049 23S rRNA interface [nucleotide binding]; other site 1064551010050 5S rRNA interface [nucleotide binding]; other site 1064551010051 L27 interface [polypeptide binding]; other site 1064551010052 L5 interface [polypeptide binding]; other site 1064551010053 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1064551010054 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1064551010055 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1064551010056 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1064551010057 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1064551010058 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1064551010059 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1064551010060 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1064551010061 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1064551010062 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1064551010063 RNA binding site [nucleotide binding]; other site 1064551010064 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1064551010065 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1064551010066 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1064551010067 23S rRNA interface [nucleotide binding]; other site 1064551010068 putative translocon interaction site; other site 1064551010069 signal recognition particle (SRP54) interaction site; other site 1064551010070 L23 interface [polypeptide binding]; other site 1064551010071 trigger factor interaction site; other site 1064551010072 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1064551010073 23S rRNA interface [nucleotide binding]; other site 1064551010074 5S rRNA interface [nucleotide binding]; other site 1064551010075 putative antibiotic binding site [chemical binding]; other site 1064551010076 L25 interface [polypeptide binding]; other site 1064551010077 L27 interface [polypeptide binding]; other site 1064551010078 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1064551010079 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1064551010080 G-X-X-G motif; other site 1064551010081 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1064551010082 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1064551010083 protein-rRNA interface [nucleotide binding]; other site 1064551010084 putative translocon binding site; other site 1064551010085 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1064551010086 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1064551010087 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1064551010088 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1064551010089 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1064551010090 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1064551010091 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 1064551010092 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1064551010093 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1064551010094 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1064551010095 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1064551010096 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1064551010097 heme binding site [chemical binding]; other site 1064551010098 ferroxidase pore; other site 1064551010099 ferroxidase diiron center [ion binding]; other site 1064551010100 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 1064551010101 elongation factor Tu; Reviewed; Region: PRK00049 1064551010102 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1064551010103 G1 box; other site 1064551010104 GEF interaction site [polypeptide binding]; other site 1064551010105 GTP/Mg2+ binding site [chemical binding]; other site 1064551010106 Switch I region; other site 1064551010107 G2 box; other site 1064551010108 G3 box; other site 1064551010109 Switch II region; other site 1064551010110 G4 box; other site 1064551010111 G5 box; other site 1064551010112 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1064551010113 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1064551010114 Antibiotic Binding Site [chemical binding]; other site 1064551010115 elongation factor G; Reviewed; Region: PRK00007 1064551010116 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1064551010117 G1 box; other site 1064551010118 putative GEF interaction site [polypeptide binding]; other site 1064551010119 GTP/Mg2+ binding site [chemical binding]; other site 1064551010120 Switch I region; other site 1064551010121 G2 box; other site 1064551010122 G3 box; other site 1064551010123 Switch II region; other site 1064551010124 G4 box; other site 1064551010125 G5 box; other site 1064551010126 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1064551010127 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1064551010128 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1064551010129 30S ribosomal protein S7; Validated; Region: PRK05302 1064551010130 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1064551010131 S17 interaction site [polypeptide binding]; other site 1064551010132 S8 interaction site; other site 1064551010133 16S rRNA interaction site [nucleotide binding]; other site 1064551010134 streptomycin interaction site [chemical binding]; other site 1064551010135 23S rRNA interaction site [nucleotide binding]; other site 1064551010136 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1064551010137 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 1064551010138 sulfur relay protein TusC; Validated; Region: PRK00211 1064551010139 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 1064551010140 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1064551010141 YheO-like PAS domain; Region: PAS_6; pfam08348 1064551010142 HTH domain; Region: HTH_22; pfam13309 1064551010143 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 1064551010144 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1064551010145 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1064551010146 phi X174 lysis protein; Provisional; Region: PRK02793 1064551010147 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1064551010148 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1064551010149 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 1064551010150 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 1064551010151 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1064551010152 TrkA-N domain; Region: TrkA_N; pfam02254 1064551010153 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 1064551010154 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1064551010155 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064551010156 Walker A/P-loop; other site 1064551010157 ATP binding site [chemical binding]; other site 1064551010158 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1064551010159 ABC transporter signature motif; other site 1064551010160 Walker B; other site 1064551010161 D-loop; other site 1064551010162 ABC transporter; Region: ABC_tran_2; pfam12848 1064551010163 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1064551010164 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064551010165 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551010166 putative monooxygenase; Provisional; Region: PRK11118 1064551010167 putative hydrolase; Provisional; Region: PRK10985 1064551010168 hypothetical protein; Provisional; Region: PRK04966 1064551010169 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 1064551010170 active site 1064551010171 hypothetical protein; Provisional; Region: PRK10738 1064551010172 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1064551010173 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1064551010174 ligand binding site [chemical binding]; other site 1064551010175 flexible hinge region; other site 1064551010176 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1064551010177 putative switch regulator; other site 1064551010178 non-specific DNA interactions [nucleotide binding]; other site 1064551010179 DNA binding site [nucleotide binding] 1064551010180 sequence specific DNA binding site [nucleotide binding]; other site 1064551010181 putative cAMP binding site [chemical binding]; other site 1064551010182 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 1064551010183 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1064551010184 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1064551010185 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 1064551010186 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1064551010187 inhibitor-cofactor binding pocket; inhibition site 1064551010188 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551010189 catalytic residue [active] 1064551010190 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1064551010191 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1064551010192 glutamine binding [chemical binding]; other site 1064551010193 catalytic triad [active] 1064551010194 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 1064551010195 cell filamentation protein Fic; Provisional; Region: PRK10347 1064551010196 hypothetical protein; Provisional; Region: PRK10204 1064551010197 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 1064551010198 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1064551010199 substrate binding site [chemical binding]; other site 1064551010200 putative transporter; Provisional; Region: PRK03699 1064551010201 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551010202 putative substrate translocation pore; other site 1064551010203 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1064551010204 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1064551010205 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1064551010206 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1064551010207 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1064551010208 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1064551010209 nitrite transporter NirC; Provisional; Region: PRK11562 1064551010210 siroheme synthase; Provisional; Region: cysG; PRK10637 1064551010211 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1064551010212 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1064551010213 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1064551010214 active site 1064551010215 SAM binding site [chemical binding]; other site 1064551010216 homodimer interface [polypeptide binding]; other site 1064551010217 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1064551010218 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 1064551010219 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1064551010220 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1064551010221 active site 1064551010222 HIGH motif; other site 1064551010223 dimer interface [polypeptide binding]; other site 1064551010224 KMSKS motif; other site 1064551010225 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1064551010226 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064551010227 motif II; other site 1064551010228 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1064551010229 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1064551010230 substrate binding site [chemical binding]; other site 1064551010231 hexamer interface [polypeptide binding]; other site 1064551010232 metal binding site [ion binding]; metal-binding site 1064551010233 DNA adenine methylase; Provisional; Region: PRK10904 1064551010234 cell division protein DamX; Validated; Region: PRK10905 1064551010235 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 1064551010236 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1064551010237 active site 1064551010238 dimer interface [polypeptide binding]; other site 1064551010239 metal binding site [ion binding]; metal-binding site 1064551010240 shikimate kinase; Reviewed; Region: aroK; PRK00131 1064551010241 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1064551010242 ADP binding site [chemical binding]; other site 1064551010243 magnesium binding site [ion binding]; other site 1064551010244 putative shikimate binding site; other site 1064551010245 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 1064551010246 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1064551010247 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 1064551010248 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 1064551010249 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1064551010250 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 1064551010251 Transglycosylase; Region: Transgly; pfam00912 1064551010252 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1064551010253 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1064551010254 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1064551010255 ADP-ribose binding site [chemical binding]; other site 1064551010256 dimer interface [polypeptide binding]; other site 1064551010257 active site 1064551010258 nudix motif; other site 1064551010259 metal binding site [ion binding]; metal-binding site 1064551010260 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 1064551010261 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1064551010262 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064551010263 motif II; other site 1064551010264 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1064551010265 RNA binding surface [nucleotide binding]; other site 1064551010266 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1064551010267 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1064551010268 dimerization interface [polypeptide binding]; other site 1064551010269 domain crossover interface; other site 1064551010270 redox-dependent activation switch; other site 1064551010271 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 1064551010272 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1064551010273 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1064551010274 active site 1064551010275 substrate-binding site [chemical binding]; other site 1064551010276 metal-binding site [ion binding] 1064551010277 ATP binding site [chemical binding]; other site 1064551010278 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1064551010279 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064551010280 dimerization interface [polypeptide binding]; other site 1064551010281 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064551010282 dimer interface [polypeptide binding]; other site 1064551010283 phosphorylation site [posttranslational modification] 1064551010284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064551010285 ATP binding site [chemical binding]; other site 1064551010286 G-X-G motif; other site 1064551010287 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1064551010288 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064551010289 active site 1064551010290 phosphorylation site [posttranslational modification] 1064551010291 intermolecular recognition site; other site 1064551010292 dimerization interface [polypeptide binding]; other site 1064551010293 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1064551010294 DNA binding site [nucleotide binding] 1064551010295 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1064551010296 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1064551010297 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1064551010298 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1064551010299 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1064551010300 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1064551010301 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1064551010302 RNA binding site [nucleotide binding]; other site 1064551010303 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 1064551010304 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 1064551010305 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1064551010306 G1 box; other site 1064551010307 GTP/Mg2+ binding site [chemical binding]; other site 1064551010308 Switch I region; other site 1064551010309 G2 box; other site 1064551010310 G3 box; other site 1064551010311 Switch II region; other site 1064551010312 G4 box; other site 1064551010313 G5 box; other site 1064551010314 Nucleoside recognition; Region: Gate; pfam07670 1064551010315 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1064551010316 Nucleoside recognition; Region: Gate; pfam07670 1064551010317 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 1064551010318 hypothetical protein; Provisional; Region: PRK09956 1064551010319 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1064551010320 carboxylesterase BioH; Provisional; Region: PRK10349 1064551010321 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1064551010322 DNA utilization protein GntX; Provisional; Region: PRK11595 1064551010323 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1064551010324 active site 1064551010325 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 1064551010326 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1064551010327 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1064551010328 high-affinity gluconate transporter; Provisional; Region: PRK14984 1064551010329 gluconate transporter; Region: gntP; TIGR00791 1064551010330 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1064551010331 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 1064551010332 maltodextrin phosphorylase; Provisional; Region: PRK14985 1064551010333 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1064551010334 homodimer interface [polypeptide binding]; other site 1064551010335 active site pocket [active] 1064551010336 transcriptional regulator MalT; Provisional; Region: PRK04841 1064551010337 AAA ATPase domain; Region: AAA_16; pfam13191 1064551010338 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064551010339 DNA binding residues [nucleotide binding] 1064551010340 dimerization interface [polypeptide binding]; other site 1064551010341 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 1064551010342 RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874 1064551010343 putative active site [active] 1064551010344 adenylation catalytic residue [active] 1064551010345 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1064551010346 hypothetical protein; Reviewed; Region: PRK09588 1064551010347 TROVE domain; Region: TROVE; pfam05731 1064551010348 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 1064551010349 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 1064551010350 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064551010351 Walker A motif; other site 1064551010352 ATP binding site [chemical binding]; other site 1064551010353 Walker B motif; other site 1064551010354 arginine finger; other site 1064551010355 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 1064551010356 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1064551010357 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1064551010358 intramembrane serine protease GlpG; Provisional; Region: PRK10907 1064551010359 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 1064551010360 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1064551010361 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1064551010362 active site residue [active] 1064551010363 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1064551010364 hypothetical protein; Provisional; Region: PRK09781 1064551010365 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 1064551010366 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1064551010367 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1064551010368 dimer interface [polypeptide binding]; other site 1064551010369 active site 1064551010370 metal binding site [ion binding]; metal-binding site 1064551010371 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551010372 D-galactonate transporter; Region: 2A0114; TIGR00893 1064551010373 putative substrate translocation pore; other site 1064551010374 Dihydroxyacid dehydratase/phosphogluconate dehydratase [Amino acid transport and metabolism / Carbohydrate transport and metabolism]; Region: IlvD; COG0129 1064551010375 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1064551010376 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1064551010377 inhibitor site; inhibition site 1064551010378 active site 1064551010379 dimer interface [polypeptide binding]; other site 1064551010380 catalytic residue [active] 1064551010381 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1064551010382 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1064551010383 Bacterial transcriptional regulator; Region: IclR; pfam01614 1064551010384 glycogen phosphorylase; Provisional; Region: PRK14986 1064551010385 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1064551010386 homodimer interface [polypeptide binding]; other site 1064551010387 active site pocket [active] 1064551010388 glycogen synthase; Provisional; Region: glgA; PRK00654 1064551010389 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1064551010390 ADP-binding pocket [chemical binding]; other site 1064551010391 homodimer interface [polypeptide binding]; other site 1064551010392 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 1064551010393 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1064551010394 ligand binding site; other site 1064551010395 oligomer interface; other site 1064551010396 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1064551010397 dimer interface [polypeptide binding]; other site 1064551010398 N-terminal domain interface [polypeptide binding]; other site 1064551010399 sulfate 1 binding site; other site 1064551010400 glycogen debranching enzyme; Provisional; Region: PRK03705 1064551010401 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1064551010402 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1064551010403 active site 1064551010404 catalytic site [active] 1064551010405 glycogen branching enzyme; Provisional; Region: PRK05402 1064551010406 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1064551010407 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1064551010408 active site 1064551010409 catalytic site [active] 1064551010410 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1064551010411 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1064551010412 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1064551010413 low affinity gluconate transporter; Provisional; Region: PRK10472 1064551010414 gluconate transporter; Region: gntP; TIGR00791 1064551010415 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1064551010416 ATP-binding site [chemical binding]; other site 1064551010417 Gluconate-6-phosphate binding site [chemical binding]; other site 1064551010418 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 1064551010419 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1064551010420 DNA binding site [nucleotide binding] 1064551010421 domain linker motif; other site 1064551010422 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1064551010423 putative ligand binding site [chemical binding]; other site 1064551010424 putative dimerization interface [polypeptide binding]; other site 1064551010425 Pirin-related protein [General function prediction only]; Region: COG1741 1064551010426 Pirin; Region: Pirin; pfam02678 1064551010427 putative oxidoreductase; Provisional; Region: PRK10206 1064551010428 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1064551010429 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1064551010430 putative acetyltransferase YhhY; Provisional; Region: PRK10140 1064551010431 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064551010432 Coenzyme A binding pocket [chemical binding]; other site 1064551010433 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1064551010434 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1064551010435 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1064551010436 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1064551010437 substrate binding site [chemical binding]; other site 1064551010438 dimer interface [polypeptide binding]; other site 1064551010439 ATP binding site [chemical binding]; other site 1064551010440 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1064551010441 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1064551010442 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1064551010443 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1064551010444 active site 1064551010445 substrate binding pocket [chemical binding]; other site 1064551010446 homodimer interaction site [polypeptide binding]; other site 1064551010447 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 1064551010448 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1064551010449 hypothetical protein; Provisional; Region: PRK10350 1064551010450 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 1064551010451 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1064551010452 putative active site [active] 1064551010453 catalytic site [active] 1064551010454 putative metal binding site [ion binding]; other site 1064551010455 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1064551010456 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1064551010457 Walker A/P-loop; other site 1064551010458 ATP binding site [chemical binding]; other site 1064551010459 Q-loop/lid; other site 1064551010460 ABC transporter signature motif; other site 1064551010461 Walker B; other site 1064551010462 D-loop; other site 1064551010463 H-loop/switch region; other site 1064551010464 TOBE domain; Region: TOBE_2; pfam08402 1064551010465 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1064551010466 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551010467 dimer interface [polypeptide binding]; other site 1064551010468 conserved gate region; other site 1064551010469 ABC-ATPase subunit interface; other site 1064551010470 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1064551010471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551010472 putative PBP binding loops; other site 1064551010473 dimer interface [polypeptide binding]; other site 1064551010474 ABC-ATPase subunit interface; other site 1064551010475 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 1064551010476 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1064551010477 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 1064551010478 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1064551010479 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 1064551010480 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1064551010481 Walker A/P-loop; other site 1064551010482 ATP binding site [chemical binding]; other site 1064551010483 Q-loop/lid; other site 1064551010484 ABC transporter signature motif; other site 1064551010485 Walker B; other site 1064551010486 D-loop; other site 1064551010487 H-loop/switch region; other site 1064551010488 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1064551010489 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1064551010490 Walker A/P-loop; other site 1064551010491 ATP binding site [chemical binding]; other site 1064551010492 Q-loop/lid; other site 1064551010493 ABC transporter signature motif; other site 1064551010494 Walker B; other site 1064551010495 D-loop; other site 1064551010496 H-loop/switch region; other site 1064551010497 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1064551010498 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1064551010499 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1064551010500 TM-ABC transporter signature motif; other site 1064551010501 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1064551010502 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1064551010503 TM-ABC transporter signature motif; other site 1064551010504 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1064551010505 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1064551010506 dimerization interface [polypeptide binding]; other site 1064551010507 ligand binding site [chemical binding]; other site 1064551010508 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 1064551010509 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1064551010510 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1064551010511 dimerization interface [polypeptide binding]; other site 1064551010512 ligand binding site [chemical binding]; other site 1064551010513 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1064551010514 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1064551010515 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1064551010516 DNA binding residues [nucleotide binding] 1064551010517 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 1064551010518 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1064551010519 cell division protein FtsE; Provisional; Region: PRK10908 1064551010520 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064551010521 Walker A/P-loop; other site 1064551010522 ATP binding site [chemical binding]; other site 1064551010523 Q-loop/lid; other site 1064551010524 ABC transporter signature motif; other site 1064551010525 Walker B; other site 1064551010526 D-loop; other site 1064551010527 H-loop/switch region; other site 1064551010528 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1064551010529 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1064551010530 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1064551010531 P loop; other site 1064551010532 GTP binding site [chemical binding]; other site 1064551010533 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1064551010534 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064551010535 S-adenosylmethionine binding site [chemical binding]; other site 1064551010536 hypothetical protein; Provisional; Region: PRK10910 1064551010537 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 1064551010538 Predicted membrane protein [Function unknown]; Region: COG3714 1064551010539 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 1064551010540 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1064551010541 metal-binding site [ion binding] 1064551010542 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1064551010543 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1064551010544 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1064551010545 dimer interface [polypeptide binding]; other site 1064551010546 ligand binding site [chemical binding]; other site 1064551010547 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064551010548 dimerization interface [polypeptide binding]; other site 1064551010549 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064551010550 dimer interface [polypeptide binding]; other site 1064551010551 putative CheW interface [polypeptide binding]; other site 1064551010552 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 1064551010553 CPxP motif; other site 1064551010554 hypothetical protein; Provisional; Region: PRK11212 1064551010555 hypothetical protein; Provisional; Region: PRK11615 1064551010556 major facilitator superfamily transporter; Provisional; Region: PRK05122 1064551010557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551010558 putative substrate translocation pore; other site 1064551010559 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1064551010560 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1064551010561 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 1064551010562 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1064551010563 nickel responsive regulator; Provisional; Region: PRK02967 1064551010564 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 1064551010565 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1064551010566 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1064551010567 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1064551010568 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1064551010569 Walker A/P-loop; other site 1064551010570 ATP binding site [chemical binding]; other site 1064551010571 Q-loop/lid; other site 1064551010572 ABC transporter signature motif; other site 1064551010573 Walker B; other site 1064551010574 D-loop; other site 1064551010575 H-loop/switch region; other site 1064551010576 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1064551010577 Walker A/P-loop; other site 1064551010578 ATP binding site [chemical binding]; other site 1064551010579 Q-loop/lid; other site 1064551010580 ABC transporter signature motif; other site 1064551010581 Walker B; other site 1064551010582 D-loop; other site 1064551010583 H-loop/switch region; other site 1064551010584 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1064551010585 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1064551010586 HlyD family secretion protein; Region: HlyD; pfam00529 1064551010587 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1064551010588 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064551010589 Predicted flavoproteins [General function prediction only]; Region: COG2081 1064551010590 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1064551010591 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1064551010592 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1064551010593 universal stress protein UspB; Provisional; Region: PRK04960 1064551010594 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1064551010595 Ligand Binding Site [chemical binding]; other site 1064551010596 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 1064551010597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551010598 putative substrate translocation pore; other site 1064551010599 POT family; Region: PTR2; pfam00854 1064551010600 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064551010601 S-adenosylmethionine binding site [chemical binding]; other site 1064551010602 oligopeptidase A; Provisional; Region: PRK10911 1064551010603 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1064551010604 active site 1064551010605 Zn binding site [ion binding]; other site 1064551010606 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 1064551010607 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1064551010608 active site 1064551010609 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1064551010610 glutathione reductase; Validated; Region: PRK06116 1064551010611 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1064551010612 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1064551010613 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1064551010614 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1064551010615 active site 1064551010616 homodimer interface [polypeptide binding]; other site 1064551010617 homotetramer interface [polypeptide binding]; other site 1064551010618 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1064551010619 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1064551010620 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 1064551010621 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1064551010622 substrate binding site [chemical binding]; other site 1064551010623 ATP binding site [chemical binding]; other site 1064551010624 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1064551010625 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1064551010626 putative active site [active] 1064551010627 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1064551010628 dimer interface [polypeptide binding]; other site 1064551010629 active site 1064551010630 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1064551010631 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064551010632 DNA-binding site [nucleotide binding]; DNA binding site 1064551010633 UTRA domain; Region: UTRA; pfam07702 1064551010634 trehalase; Provisional; Region: treF; PRK13270 1064551010635 Trehalase; Region: Trehalase; pfam01204 1064551010636 Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772 1064551010637 catalytic residue [active] 1064551010638 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1064551010639 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1064551010640 active site 1064551010641 phosphorylation site [posttranslational modification] 1064551010642 dimerization interface [polypeptide binding]; other site 1064551010643 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064551010644 DNA binding residues [nucleotide binding] 1064551010645 dimerization interface [polypeptide binding]; other site 1064551010646 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064551010647 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551010648 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1064551010649 putative effector binding pocket; other site 1064551010650 putative dimerization interface [polypeptide binding]; other site 1064551010651 inner membrane protein YhjD; Region: TIGR00766 1064551010652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551010653 metabolite-proton symporter; Region: 2A0106; TIGR00883 1064551010654 putative substrate translocation pore; other site 1064551010655 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1064551010656 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1064551010657 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1064551010658 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1064551010659 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1064551010660 substrate binding site [chemical binding]; other site 1064551010661 ATP binding site [chemical binding]; other site 1064551010662 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1064551010663 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1064551010664 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1064551010665 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1064551010666 putative diguanylate cyclase; Provisional; Region: PRK13561 1064551010667 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064551010668 metal binding site [ion binding]; metal-binding site 1064551010669 active site 1064551010670 I-site; other site 1064551010671 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1064551010672 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 1064551010673 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064551010674 TPR motif; other site 1064551010675 binding surface 1064551010676 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064551010677 TPR motif; other site 1064551010678 binding surface 1064551010679 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1064551010680 binding surface 1064551010681 TPR motif; other site 1064551010682 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 1064551010683 endo-1,4-D-glucanase; Provisional; Region: PRK11097 1064551010684 cellulose synthase regulator protein; Provisional; Region: PRK11114 1064551010685 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 1064551010686 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1064551010687 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1064551010688 DXD motif; other site 1064551010689 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1064551010690 PilZ domain; Region: PilZ; pfam07238 1064551010691 cell division protein; Provisional; Region: PRK10037 1064551010692 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 1064551010693 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 1064551010694 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 1064551010695 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 1064551010696 cellulose synthase operon protein YhjU; Region: cellulose_yhjU; TIGR03368 1064551010697 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 1064551010698 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1064551010699 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1064551010700 dipeptide transporter; Provisional; Region: PRK10913 1064551010701 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1064551010702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551010703 dimer interface [polypeptide binding]; other site 1064551010704 conserved gate region; other site 1064551010705 putative PBP binding loops; other site 1064551010706 ABC-ATPase subunit interface; other site 1064551010707 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1064551010708 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551010709 dimer interface [polypeptide binding]; other site 1064551010710 conserved gate region; other site 1064551010711 putative PBP binding loops; other site 1064551010712 ABC-ATPase subunit interface; other site 1064551010713 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1064551010714 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1064551010715 peptide binding site [polypeptide binding]; other site 1064551010716 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1064551010717 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 1064551010718 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1064551010719 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1064551010720 DNA binding site [nucleotide binding] 1064551010721 domain linker motif; other site 1064551010722 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_8; cd06287 1064551010723 putative dimerization interface [polypeptide binding]; other site 1064551010724 putative ligand binding site [chemical binding]; other site 1064551010725 phosphoethanolamine transferase; Provisional; Region: PRK11560 1064551010726 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1064551010727 Sulfatase; Region: Sulfatase; pfam00884 1064551010728 long polar fimbrial protein LpfE; Provisional; Region: PRK15205 1064551010729 long polar fimbrial protein LpfD; Provisional; Region: PRK15206 1064551010730 long polar fimbrial outer membrane usher protein LpfC; Provisional; Region: PRK15207 1064551010731 PapC N-terminal domain; Region: PapC_N; pfam13954 1064551010732 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1064551010733 PapC C-terminal domain; Region: PapC_C; pfam13953 1064551010734 long polar fimbrial chaperone LpfB; Provisional; Region: PRK15208 1064551010735 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1064551010736 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1064551010737 long polar fimbrial protein LpfA; Provisional; Region: PRK15209 1064551010738 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 1064551010739 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 1064551010740 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064551010741 Coenzyme A binding pocket [chemical binding]; other site 1064551010742 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1064551010743 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1064551010744 molybdopterin cofactor binding site [chemical binding]; other site 1064551010745 substrate binding site [chemical binding]; other site 1064551010746 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1064551010747 molybdopterin cofactor binding site; other site 1064551010748 putative outer membrane lipoprotein; Provisional; Region: PRK10510 1064551010749 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1064551010750 ligand binding site [chemical binding]; other site 1064551010751 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1064551010752 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1064551010753 dimerization interface [polypeptide binding]; other site 1064551010754 ligand binding site [chemical binding]; other site 1064551010755 NADP binding site [chemical binding]; other site 1064551010756 catalytic site [active] 1064551010757 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 1064551010758 Predicted transcriptional regulator [Transcription]; Region: COG2944 1064551010759 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064551010760 salt bridge; other site 1064551010761 non-specific DNA binding site [nucleotide binding]; other site 1064551010762 sequence-specific DNA binding site [nucleotide binding]; other site 1064551010763 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1064551010764 DNA-binding site [nucleotide binding]; DNA binding site 1064551010765 RNA-binding motif; other site 1064551010766 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1064551010767 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1064551010768 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1064551010769 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064551010770 Coenzyme A binding pocket [chemical binding]; other site 1064551010771 Integrase core domain; Region: rve; pfam00665 1064551010772 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1064551010773 DALR anticodon binding domain; Region: DALR_1; pfam05746 1064551010774 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1064551010775 dimer interface [polypeptide binding]; other site 1064551010776 motif 1; other site 1064551010777 active site 1064551010778 motif 2; other site 1064551010779 motif 3; other site 1064551010780 YsaB-like lipoprotein; Region: YsaB; pfam13983 1064551010781 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1064551010782 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1064551010783 Predicted membrane protein [Function unknown]; Region: COG4682 1064551010784 yiaA/B two helix domain; Region: YiaAB; cl01759 1064551010785 yiaA/B two helix domain; Region: YiaAB; cl01759 1064551010786 xylulokinase; Provisional; Region: PRK15027 1064551010787 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1064551010788 N- and C-terminal domain interface [polypeptide binding]; other site 1064551010789 active site 1064551010790 MgATP binding site [chemical binding]; other site 1064551010791 catalytic site [active] 1064551010792 metal binding site [ion binding]; metal-binding site 1064551010793 xylulose binding site [chemical binding]; other site 1064551010794 homodimer interface [polypeptide binding]; other site 1064551010795 xylose isomerase; Provisional; Region: PRK05474 1064551010796 xylose isomerase; Region: xylose_isom_A; TIGR02630 1064551010797 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 1064551010798 putative dimerization interface [polypeptide binding]; other site 1064551010799 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1064551010800 putative ligand binding site [chemical binding]; other site 1064551010801 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064551010802 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1064551010803 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064551010804 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 1064551010805 hypothetical protein; Provisional; Region: PRK10356 1064551010806 alpha-amylase; Reviewed; Region: malS; PRK09505 1064551010807 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1064551010808 active site 1064551010809 catalytic site [active] 1064551010810 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 1064551010811 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1064551010812 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551010813 homodimer interface [polypeptide binding]; other site 1064551010814 catalytic residue [active] 1064551010815 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 1064551010816 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1064551010817 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1064551010818 Bacterial transcriptional regulator; Region: IclR; pfam01614 1064551010819 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 1064551010820 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1064551010821 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 1064551010822 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 1064551010823 DctM-like transporters; Region: DctM; pfam06808 1064551010824 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1064551010825 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 1064551010826 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1064551010827 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 1064551010828 putative N- and C-terminal domain interface [polypeptide binding]; other site 1064551010829 putative active site [active] 1064551010830 MgATP binding site [chemical binding]; other site 1064551010831 catalytic site [active] 1064551010832 metal binding site [ion binding]; metal-binding site 1064551010833 putative xylulose binding site [chemical binding]; other site 1064551010834 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1064551010835 active site 1064551010836 dimer interface [polypeptide binding]; other site 1064551010837 magnesium binding site [ion binding]; other site 1064551010838 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 1064551010839 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1064551010840 AP (apurinic/apyrimidinic) site pocket; other site 1064551010841 DNA interaction; other site 1064551010842 Metal-binding active site; metal-binding site 1064551010843 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1064551010844 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1064551010845 intersubunit interface [polypeptide binding]; other site 1064551010846 active site 1064551010847 Zn2+ binding site [ion binding]; other site 1064551010848 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1064551010849 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1064551010850 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064551010851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1064551010852 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1064551010853 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1064551010854 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1064551010855 NAD(P) binding site [chemical binding]; other site 1064551010856 catalytic residues [active] 1064551010857 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1064551010858 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1064551010859 nucleotide binding site [chemical binding]; other site 1064551010860 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 1064551010861 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1064551010862 G1 box; other site 1064551010863 putative GEF interaction site [polypeptide binding]; other site 1064551010864 GTP/Mg2+ binding site [chemical binding]; other site 1064551010865 Switch I region; other site 1064551010866 G2 box; other site 1064551010867 G3 box; other site 1064551010868 Switch II region; other site 1064551010869 G4 box; other site 1064551010870 G5 box; other site 1064551010871 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1064551010872 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 1064551010873 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 1064551010874 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1064551010875 selenocysteine synthase; Provisional; Region: PRK04311 1064551010876 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 1064551010877 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 1064551010878 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1064551010879 catalytic residue [active] 1064551010880 putative glutathione S-transferase; Provisional; Region: PRK10357 1064551010881 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 1064551010882 putative C-terminal domain interface [polypeptide binding]; other site 1064551010883 putative GSH binding site (G-site) [chemical binding]; other site 1064551010884 putative dimer interface [polypeptide binding]; other site 1064551010885 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1064551010886 dimer interface [polypeptide binding]; other site 1064551010887 N-terminal domain interface [polypeptide binding]; other site 1064551010888 putative substrate binding pocket (H-site) [chemical binding]; other site 1064551010889 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1064551010890 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1064551010891 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064551010892 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 1064551010893 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 1064551010894 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1064551010895 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1064551010896 active site 1064551010897 P-loop; other site 1064551010898 phosphorylation site [posttranslational modification] 1064551010899 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1064551010900 active site 1064551010901 phosphorylation site [posttranslational modification] 1064551010902 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1064551010903 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1064551010904 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1064551010905 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 1064551010906 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 1064551010907 hypothetical protein; Provisional; Region: PRK11020 1064551010908 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 1064551010909 L-lactate permease; Provisional; Region: PRK10420 1064551010910 glycolate transporter; Provisional; Region: PRK09695 1064551010911 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 1064551010912 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064551010913 DNA-binding site [nucleotide binding]; DNA binding site 1064551010914 FCD domain; Region: FCD; pfam07729 1064551010915 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 1064551010916 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1064551010917 active site 1064551010918 substrate binding site [chemical binding]; other site 1064551010919 FMN binding site [chemical binding]; other site 1064551010920 putative catalytic residues [active] 1064551010921 putative rRNA methylase; Provisional; Region: PRK10358 1064551010922 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1064551010923 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1064551010924 DNA binding site [nucleotide binding] 1064551010925 domain linker motif; other site 1064551010926 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1064551010927 putative dimerization interface [polypeptide binding]; other site 1064551010928 putative ligand binding site [chemical binding]; other site 1064551010929 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1064551010930 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1064551010931 active site pocket [active] 1064551010932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551010933 D-galactonate transporter; Region: 2A0114; TIGR00893 1064551010934 putative substrate translocation pore; other site 1064551010935 serine acetyltransferase; Provisional; Region: cysE; PRK11132 1064551010936 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 1064551010937 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1064551010938 trimer interface [polypeptide binding]; other site 1064551010939 active site 1064551010940 substrate binding site [chemical binding]; other site 1064551010941 CoA binding site [chemical binding]; other site 1064551010942 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1064551010943 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1064551010944 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1064551010945 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 1064551010946 SecA binding site; other site 1064551010947 Preprotein binding site; other site 1064551010948 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1064551010949 GSH binding site [chemical binding]; other site 1064551010950 catalytic residues [active] 1064551010951 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1064551010952 active site residue [active] 1064551010953 phosphoglyceromutase; Provisional; Region: PRK05434 1064551010954 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 1064551010955 AmiB activator; Provisional; Region: PRK11637 1064551010956 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1064551010957 Peptidase family M23; Region: Peptidase_M23; pfam01551 1064551010958 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1064551010959 NodB motif; other site 1064551010960 putative active site [active] 1064551010961 putative catalytic site [active] 1064551010962 Zn binding site [ion binding]; other site 1064551010963 putative glycosyl transferase; Provisional; Region: PRK10073 1064551010964 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1064551010965 active site 1064551010966 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1064551010967 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1064551010968 NAD(P) binding site [chemical binding]; other site 1064551010969 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1064551010970 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1064551010971 substrate-cofactor binding pocket; other site 1064551010972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551010973 catalytic residue [active] 1064551010974 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 1064551010975 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 1064551010976 NADP binding site [chemical binding]; other site 1064551010977 homopentamer interface [polypeptide binding]; other site 1064551010978 substrate binding site [chemical binding]; other site 1064551010979 active site 1064551010980 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1064551010981 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1064551010982 putative active site [active] 1064551010983 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1064551010984 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1064551010985 putative active site [active] 1064551010986 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1064551010987 O-antigen ligase RfaL; Provisional; Region: PRK15487 1064551010988 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 1064551010989 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1064551010990 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 1064551010991 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176 1064551010992 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 1064551010993 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1064551010994 Ligand binding site; other site 1064551010995 metal-binding site 1064551010996 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 1064551010997 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 1064551010998 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1064551010999 Ligand binding site; other site 1064551011000 metal-binding site 1064551011001 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 1064551011002 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 1064551011003 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1064551011004 putative ADP-binding pocket [chemical binding]; other site 1064551011005 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1064551011006 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 1064551011007 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1064551011008 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1064551011009 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 1064551011010 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1064551011011 putative active site [active] 1064551011012 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1064551011013 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1064551011014 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1064551011015 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1064551011016 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1064551011017 active site 1064551011018 (T/H)XGH motif; other site 1064551011019 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1064551011020 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1064551011021 DNA binding site [nucleotide binding] 1064551011022 catalytic residue [active] 1064551011023 H2TH interface [polypeptide binding]; other site 1064551011024 putative catalytic residues [active] 1064551011025 turnover-facilitating residue; other site 1064551011026 intercalation triad [nucleotide binding]; other site 1064551011027 8OG recognition residue [nucleotide binding]; other site 1064551011028 putative reading head residues; other site 1064551011029 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1064551011030 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1064551011031 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1064551011032 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1064551011033 hypothetical protein; Reviewed; Region: PRK00024 1064551011034 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1064551011035 MPN+ (JAMM) motif; other site 1064551011036 Zinc-binding site [ion binding]; other site 1064551011037 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1064551011038 Flavoprotein; Region: Flavoprotein; pfam02441 1064551011039 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1064551011040 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1064551011041 trimer interface [polypeptide binding]; other site 1064551011042 active site 1064551011043 division inhibitor protein; Provisional; Region: slmA; PRK09480 1064551011044 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1064551011045 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1064551011046 active site 1064551011047 ribonuclease PH; Reviewed; Region: rph; PRK00173 1064551011048 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1064551011049 hexamer interface [polypeptide binding]; other site 1064551011050 active site 1064551011051 hypothetical protein; Provisional; Region: PRK11820 1064551011052 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1064551011053 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1064551011054 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064551011055 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551011056 dimerization interface [polypeptide binding]; other site 1064551011057 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1064551011058 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1064551011059 Predicted membrane protein [Function unknown]; Region: COG2860 1064551011060 UPF0126 domain; Region: UPF0126; pfam03458 1064551011061 UPF0126 domain; Region: UPF0126; pfam03458 1064551011062 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 1064551011063 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 1064551011064 nucleotide binding pocket [chemical binding]; other site 1064551011065 K-X-D-G motif; other site 1064551011066 catalytic site [active] 1064551011067 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1064551011068 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1064551011069 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1064551011070 catalytic site [active] 1064551011071 G-X2-G-X-G-K; other site 1064551011072 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1064551011073 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 1064551011074 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1064551011075 Zn2+ binding site [ion binding]; other site 1064551011076 Mg2+ binding site [ion binding]; other site 1064551011077 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1064551011078 synthetase active site [active] 1064551011079 NTP binding site [chemical binding]; other site 1064551011080 metal binding site [ion binding]; metal-binding site 1064551011081 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1064551011082 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1064551011083 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 1064551011084 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1064551011085 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 1064551011086 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1064551011087 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1064551011088 generic binding surface II; other site 1064551011089 ssDNA binding site; other site 1064551011090 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1064551011091 ATP binding site [chemical binding]; other site 1064551011092 putative Mg++ binding site [ion binding]; other site 1064551011093 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1064551011094 nucleotide binding region [chemical binding]; other site 1064551011095 ATP-binding site [chemical binding]; other site 1064551011096 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 1064551011097 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1064551011098 AsmA family; Region: AsmA; pfam05170 1064551011099 putative alpha-glucosidase; Provisional; Region: PRK10658 1064551011100 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1064551011101 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 1064551011102 active site 1064551011103 homotrimer interface [polypeptide binding]; other site 1064551011104 catalytic site [active] 1064551011105 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 1064551011106 putative transporter; Provisional; Region: PRK11462 1064551011107 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1064551011108 autotransport protein MisL; Provisional; Region: PRK15313 1064551011109 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1064551011110 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1064551011111 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1064551011112 DNA binding site [nucleotide binding] 1064551011113 Isochorismatase family; Region: Isochorismatase; pfam00857 1064551011114 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1064551011115 catalytic triad [active] 1064551011116 dimer interface [polypeptide binding]; other site 1064551011117 conserved cis-peptide bond; other site 1064551011118 magnesium-transporting ATPase; Provisional; Region: PRK15122 1064551011119 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1064551011120 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1064551011121 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1064551011122 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064551011123 motif II; other site 1064551011124 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1064551011125 magnesium transport protein MgtC; Provisional; Region: PRK15385 1064551011126 MgtC family; Region: MgtC; pfam02308 1064551011127 EamA-like transporter family; Region: EamA; pfam00892 1064551011128 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1064551011129 EamA-like transporter family; Region: EamA; pfam00892 1064551011130 hypothetical protein; Provisional; Region: PRK09956 1064551011131 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1064551011132 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 1064551011133 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 1064551011134 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 1064551011135 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1064551011136 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 1064551011137 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1064551011138 active site 1064551011139 phosphorylation site [posttranslational modification] 1064551011140 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1064551011141 active pocket/dimerization site; other site 1064551011142 active site 1064551011143 phosphorylation site [posttranslational modification] 1064551011144 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1064551011145 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064551011146 Walker A motif; other site 1064551011147 ATP binding site [chemical binding]; other site 1064551011148 Walker B motif; other site 1064551011149 arginine finger; other site 1064551011150 Transcriptional antiterminator [Transcription]; Region: COG3933 1064551011151 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1064551011152 active site 1064551011153 active pocket/dimerization site; other site 1064551011154 phosphorylation site [posttranslational modification] 1064551011155 PRD domain; Region: PRD; pfam00874 1064551011156 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1064551011157 beta-galactosidase; Region: BGL; TIGR03356 1064551011158 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 1064551011159 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551011160 putative substrate translocation pore; other site 1064551011161 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737 1064551011162 Predicted transcriptional regulator [Transcription]; Region: COG2944 1064551011163 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064551011164 non-specific DNA binding site [nucleotide binding]; other site 1064551011165 salt bridge; other site 1064551011166 sequence-specific DNA binding site [nucleotide binding]; other site 1064551011167 GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440 1064551011168 GIY-YIG motif/motif A; other site 1064551011169 putative active site [active] 1064551011170 putative metal binding site [ion binding]; other site 1064551011171 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1064551011172 dimerization domain swap beta strand [polypeptide binding]; other site 1064551011173 regulatory protein interface [polypeptide binding]; other site 1064551011174 active site 1064551011175 regulatory phosphorylation site [posttranslational modification]; other site 1064551011176 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1064551011177 intersubunit interface [polypeptide binding]; other site 1064551011178 active site 1064551011179 zinc binding site [ion binding]; other site 1064551011180 Na+ binding site [ion binding]; other site 1064551011181 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1064551011182 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 1064551011183 putative N- and C-terminal domain interface [polypeptide binding]; other site 1064551011184 putative active site [active] 1064551011185 putative MgATP binding site [chemical binding]; other site 1064551011186 catalytic site [active] 1064551011187 metal binding site [ion binding]; metal-binding site 1064551011188 putative carbohydrate binding site [chemical binding]; other site 1064551011189 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1064551011190 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1064551011191 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1064551011192 active site 1064551011193 P-loop; other site 1064551011194 phosphorylation site [posttranslational modification] 1064551011195 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1064551011196 active site 1064551011197 phosphorylation site [posttranslational modification] 1064551011198 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1064551011199 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064551011200 DNA-binding site [nucleotide binding]; DNA binding site 1064551011201 UTRA domain; Region: UTRA; pfam07702 1064551011202 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 1064551011203 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 1064551011204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551011205 putative substrate translocation pore; other site 1064551011206 regulatory protein UhpC; Provisional; Region: PRK11663 1064551011207 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551011208 putative substrate translocation pore; other site 1064551011209 sensory histidine kinase UhpB; Provisional; Region: PRK11644 1064551011210 MASE1; Region: MASE1; pfam05231 1064551011211 Histidine kinase; Region: HisKA_3; pfam07730 1064551011212 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064551011213 ATP binding site [chemical binding]; other site 1064551011214 Mg2+ binding site [ion binding]; other site 1064551011215 G-X-G motif; other site 1064551011216 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 1064551011217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064551011218 active site 1064551011219 phosphorylation site [posttranslational modification] 1064551011220 intermolecular recognition site; other site 1064551011221 dimerization interface [polypeptide binding]; other site 1064551011222 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064551011223 DNA binding residues [nucleotide binding] 1064551011224 dimerization interface [polypeptide binding]; other site 1064551011225 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 1064551011226 active site 1064551011227 catalytic residues [active] 1064551011228 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1064551011229 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551011230 putative substrate translocation pore; other site 1064551011231 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1064551011232 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1064551011233 substrate binding site [chemical binding]; other site 1064551011234 dimer interface [polypeptide binding]; other site 1064551011235 ATP binding site [chemical binding]; other site 1064551011236 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 1064551011237 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1064551011238 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1064551011239 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 1064551011240 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1064551011241 putative valine binding site [chemical binding]; other site 1064551011242 dimer interface [polypeptide binding]; other site 1064551011243 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 1064551011244 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1064551011245 PYR/PP interface [polypeptide binding]; other site 1064551011246 dimer interface [polypeptide binding]; other site 1064551011247 TPP binding site [chemical binding]; other site 1064551011248 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1064551011249 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1064551011250 TPP-binding site [chemical binding]; other site 1064551011251 dimer interface [polypeptide binding]; other site 1064551011252 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1064551011253 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1064551011254 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 1064551011255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551011256 putative substrate translocation pore; other site 1064551011257 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1064551011258 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 1064551011259 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551011260 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1064551011261 dimerization interface [polypeptide binding]; other site 1064551011262 substrate binding pocket [chemical binding]; other site 1064551011263 permease DsdX; Provisional; Region: PRK09921 1064551011264 gluconate transporter; Region: gntP; TIGR00791 1064551011265 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1064551011266 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1064551011267 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1064551011268 catalytic residue [active] 1064551011269 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 1064551011270 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 1064551011271 Domain of unknown function (DUF202); Region: DUF202; pfam02656 1064551011272 Predicted membrane protein [Function unknown]; Region: COG2149 1064551011273 putative transporter; Validated; Region: PRK03818 1064551011274 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1064551011275 TrkA-C domain; Region: TrkA_C; pfam02080 1064551011276 TrkA-C domain; Region: TrkA_C; pfam02080 1064551011277 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1064551011278 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1064551011279 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1064551011280 putative dimer interface [polypeptide binding]; other site 1064551011281 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1064551011282 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1064551011283 putative dimer interface [polypeptide binding]; other site 1064551011284 hypothetical protein; Provisional; Region: PRK11616 1064551011285 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 1064551011286 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 1064551011287 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 1064551011288 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 1064551011289 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1064551011290 catalytic residues [active] 1064551011291 central insert; other site 1064551011292 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150 1064551011293 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 1064551011294 heme exporter protein CcmC; Region: ccmC; TIGR01191 1064551011295 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386 1064551011296 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 1064551011297 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064551011298 Walker A/P-loop; other site 1064551011299 ATP binding site [chemical binding]; other site 1064551011300 Q-loop/lid; other site 1064551011301 ABC transporter signature motif; other site 1064551011302 Walker B; other site 1064551011303 D-loop; other site 1064551011304 H-loop/switch region; other site 1064551011305 Haem-binding domain; Region: Haem_bd; pfam14376 1064551011306 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 1064551011307 chaperone protein TorD; Validated; Region: torD; PRK04976 1064551011308 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 1064551011309 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1064551011310 molybdopterin cofactor binding site [chemical binding]; other site 1064551011311 substrate binding site [chemical binding]; other site 1064551011312 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1064551011313 molybdopterin cofactor binding site; other site 1064551011314 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 1064551011315 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 1064551011316 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 1064551011317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064551011318 active site 1064551011319 phosphorylation site [posttranslational modification] 1064551011320 intermolecular recognition site; other site 1064551011321 dimerization interface [polypeptide binding]; other site 1064551011322 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1064551011323 DNA binding site [nucleotide binding] 1064551011324 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 1064551011325 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1064551011326 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 1064551011327 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064551011328 dimer interface [polypeptide binding]; other site 1064551011329 phosphorylation site [posttranslational modification] 1064551011330 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064551011331 ATP binding site [chemical binding]; other site 1064551011332 Mg2+ binding site [ion binding]; other site 1064551011333 G-X-G motif; other site 1064551011334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064551011335 active site 1064551011336 phosphorylation site [posttranslational modification] 1064551011337 intermolecular recognition site; other site 1064551011338 dimerization interface [polypeptide binding]; other site 1064551011339 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1064551011340 putative binding surface; other site 1064551011341 active site 1064551011342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551011343 D-galactonate transporter; Region: 2A0114; TIGR00893 1064551011344 putative substrate translocation pore; other site 1064551011345 galactonate dehydratase; Provisional; Region: PRK14017 1064551011346 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 1064551011347 putative active site pocket [active] 1064551011348 putative metal binding site [ion binding]; other site 1064551011349 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 1064551011350 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1064551011351 active site 1064551011352 intersubunit interface [polypeptide binding]; other site 1064551011353 catalytic residue [active] 1064551011354 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 1064551011355 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 1064551011356 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1064551011357 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064551011358 DNA-binding site [nucleotide binding]; DNA binding site 1064551011359 FCD domain; Region: FCD; pfam07729 1064551011360 sugar phosphate phosphatase; Provisional; Region: PRK10513 1064551011361 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064551011362 active site 1064551011363 motif I; other site 1064551011364 motif II; other site 1064551011365 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064551011366 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551011367 D-galactonate transporter; Region: 2A0114; TIGR00893 1064551011368 putative substrate translocation pore; other site 1064551011369 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551011370 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1064551011371 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1064551011372 active site pocket [active] 1064551011373 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064551011374 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551011375 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1064551011376 putative dimerization interface [polypeptide binding]; other site 1064551011377 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1064551011378 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064551011379 Mg2+ binding site [ion binding]; other site 1064551011380 G-X-G motif; other site 1064551011381 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1064551011382 anchoring element; other site 1064551011383 dimer interface [polypeptide binding]; other site 1064551011384 ATP binding site [chemical binding]; other site 1064551011385 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1064551011386 active site 1064551011387 putative metal-binding site [ion binding]; other site 1064551011388 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1064551011389 recF protein; Region: recf; TIGR00611 1064551011390 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064551011391 Walker A/P-loop; other site 1064551011392 ATP binding site [chemical binding]; other site 1064551011393 Q-loop/lid; other site 1064551011394 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064551011395 ABC transporter signature motif; other site 1064551011396 Walker B; other site 1064551011397 D-loop; other site 1064551011398 H-loop/switch region; other site 1064551011399 DNA polymerase III subunit beta; Validated; Region: PRK05643 1064551011400 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1064551011401 putative DNA binding surface [nucleotide binding]; other site 1064551011402 dimer interface [polypeptide binding]; other site 1064551011403 beta-clamp/clamp loader binding surface; other site 1064551011404 beta-clamp/translesion DNA polymerase binding surface; other site 1064551011405 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1064551011406 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1064551011407 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064551011408 Walker A motif; other site 1064551011409 ATP binding site [chemical binding]; other site 1064551011410 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1064551011411 Walker B motif; other site 1064551011412 arginine finger; other site 1064551011413 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1064551011414 DnaA box-binding interface [nucleotide binding]; other site 1064551011415 ribonuclease P; Reviewed; Region: rnpA; PRK01732 1064551011416 membrane protein insertase; Provisional; Region: PRK01318 1064551011417 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1064551011418 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1064551011419 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1064551011420 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1064551011421 G1 box; other site 1064551011422 GTP/Mg2+ binding site [chemical binding]; other site 1064551011423 Switch I region; other site 1064551011424 G2 box; other site 1064551011425 Switch II region; other site 1064551011426 G3 box; other site 1064551011427 G4 box; other site 1064551011428 G5 box; other site 1064551011429 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1064551011430 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 1064551011431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551011432 putative substrate translocation pore; other site 1064551011433 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 1064551011434 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551011435 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1064551011436 substrate binding pocket [chemical binding]; other site 1064551011437 dimerization interface [polypeptide binding]; other site 1064551011438 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1064551011439 Predicted flavoprotein [General function prediction only]; Region: COG0431 1064551011440 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1064551011441 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1064551011442 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 1064551011443 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064551011444 active site 1064551011445 motif I; other site 1064551011446 motif II; other site 1064551011447 transcriptional regulator PhoU; Provisional; Region: PRK11115 1064551011448 PhoU domain; Region: PhoU; pfam01895 1064551011449 PhoU domain; Region: PhoU; pfam01895 1064551011450 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 1064551011451 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1064551011452 Walker A/P-loop; other site 1064551011453 ATP binding site [chemical binding]; other site 1064551011454 Q-loop/lid; other site 1064551011455 ABC transporter signature motif; other site 1064551011456 Walker B; other site 1064551011457 D-loop; other site 1064551011458 H-loop/switch region; other site 1064551011459 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 1064551011460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551011461 dimer interface [polypeptide binding]; other site 1064551011462 conserved gate region; other site 1064551011463 putative PBP binding loops; other site 1064551011464 ABC-ATPase subunit interface; other site 1064551011465 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 1064551011466 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551011467 dimer interface [polypeptide binding]; other site 1064551011468 conserved gate region; other site 1064551011469 putative PBP binding loops; other site 1064551011470 ABC-ATPase subunit interface; other site 1064551011471 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064551011472 substrate binding pocket [chemical binding]; other site 1064551011473 membrane-bound complex binding site; other site 1064551011474 hinge residues; other site 1064551011475 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1064551011476 active site 1064551011477 P-loop; other site 1064551011478 phosphorylation site [posttranslational modification] 1064551011479 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 1064551011480 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1064551011481 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 1064551011482 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1064551011483 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1064551011484 shikimate binding site; other site 1064551011485 NAD(P) binding site [chemical binding]; other site 1064551011486 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1064551011487 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1064551011488 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1064551011489 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1064551011490 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1064551011491 glutaminase active site [active] 1064551011492 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1064551011493 dimer interface [polypeptide binding]; other site 1064551011494 active site 1064551011495 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1064551011496 dimer interface [polypeptide binding]; other site 1064551011497 active site 1064551011498 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 1064551011499 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1064551011500 Substrate binding site; other site 1064551011501 Mg++ binding site; other site 1064551011502 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1064551011503 active site 1064551011504 substrate binding site [chemical binding]; other site 1064551011505 CoA binding site [chemical binding]; other site 1064551011506 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1064551011507 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 1064551011508 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1064551011509 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1064551011510 gamma subunit interface [polypeptide binding]; other site 1064551011511 epsilon subunit interface [polypeptide binding]; other site 1064551011512 LBP interface [polypeptide binding]; other site 1064551011513 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1064551011514 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1064551011515 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1064551011516 alpha subunit interaction interface [polypeptide binding]; other site 1064551011517 Walker A motif; other site 1064551011518 ATP binding site [chemical binding]; other site 1064551011519 Walker B motif; other site 1064551011520 inhibitor binding site; inhibition site 1064551011521 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1064551011522 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1064551011523 core domain interface [polypeptide binding]; other site 1064551011524 delta subunit interface [polypeptide binding]; other site 1064551011525 epsilon subunit interface [polypeptide binding]; other site 1064551011526 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1064551011527 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1064551011528 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1064551011529 beta subunit interaction interface [polypeptide binding]; other site 1064551011530 Walker A motif; other site 1064551011531 ATP binding site [chemical binding]; other site 1064551011532 Walker B motif; other site 1064551011533 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1064551011534 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1064551011535 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1064551011536 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1064551011537 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1064551011538 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1064551011539 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1064551011540 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1064551011541 ATP synthase I chain; Region: ATP_synt_I; cl09170 1064551011542 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1064551011543 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064551011544 S-adenosylmethionine binding site [chemical binding]; other site 1064551011545 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1064551011546 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1064551011547 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1064551011548 FMN-binding protein MioC; Provisional; Region: PRK09004 1064551011549 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 1064551011550 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1064551011551 putative DNA binding site [nucleotide binding]; other site 1064551011552 putative Zn2+ binding site [ion binding]; other site 1064551011553 AsnC family; Region: AsnC_trans_reg; pfam01037 1064551011554 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 1064551011555 dimer interface [polypeptide binding]; other site 1064551011556 active site 1064551011557 hypothetical protein; Provisional; Region: yieM; PRK10997 1064551011558 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1064551011559 metal ion-dependent adhesion site (MIDAS); other site 1064551011560 regulatory ATPase RavA; Provisional; Region: PRK13531 1064551011561 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064551011562 Walker A motif; other site 1064551011563 ATP binding site [chemical binding]; other site 1064551011564 Walker B motif; other site 1064551011565 arginine finger; other site 1064551011566 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 1064551011567 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 1064551011568 potassium uptake protein; Region: kup; TIGR00794 1064551011569 D-ribose pyranase; Provisional; Region: PRK11797 1064551011570 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 1064551011571 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1064551011572 Walker A/P-loop; other site 1064551011573 ATP binding site [chemical binding]; other site 1064551011574 Q-loop/lid; other site 1064551011575 ABC transporter signature motif; other site 1064551011576 Walker B; other site 1064551011577 D-loop; other site 1064551011578 H-loop/switch region; other site 1064551011579 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1064551011580 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1064551011581 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1064551011582 TM-ABC transporter signature motif; other site 1064551011583 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1064551011584 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1064551011585 ligand binding site [chemical binding]; other site 1064551011586 dimerization interface [polypeptide binding]; other site 1064551011587 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1064551011588 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1064551011589 substrate binding site [chemical binding]; other site 1064551011590 dimer interface [polypeptide binding]; other site 1064551011591 ATP binding site [chemical binding]; other site 1064551011592 transcriptional repressor RbsR; Provisional; Region: PRK10423 1064551011593 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1064551011594 DNA binding site [nucleotide binding] 1064551011595 domain linker motif; other site 1064551011596 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1064551011597 dimerization interface [polypeptide binding]; other site 1064551011598 ligand binding site [chemical binding]; other site 1064551011599 putative transporter; Provisional; Region: PRK10504 1064551011600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551011601 putative substrate translocation pore; other site 1064551011602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551011603 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1064551011604 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064551011605 DNA-binding site [nucleotide binding]; DNA binding site 1064551011606 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1064551011607 transcriptional regulator HdfR; Provisional; Region: PRK03601 1064551011608 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551011609 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1064551011610 dimerization interface [polypeptide binding]; other site 1064551011611 hypothetical protein; Provisional; Region: PRK11027 1064551011612 putative ATP-dependent protease; Provisional; Region: PRK09862 1064551011613 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1064551011614 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064551011615 Walker A motif; other site 1064551011616 ATP binding site [chemical binding]; other site 1064551011617 Walker B motif; other site 1064551011618 arginine finger; other site 1064551011619 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1064551011620 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 1064551011621 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1064551011622 PYR/PP interface [polypeptide binding]; other site 1064551011623 dimer interface [polypeptide binding]; other site 1064551011624 TPP binding site [chemical binding]; other site 1064551011625 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1064551011626 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1064551011627 TPP-binding site [chemical binding]; other site 1064551011628 dimer interface [polypeptide binding]; other site 1064551011629 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 1064551011630 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1064551011631 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1064551011632 homodimer interface [polypeptide binding]; other site 1064551011633 substrate-cofactor binding pocket; other site 1064551011634 catalytic residue [active] 1064551011635 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1064551011636 threonine dehydratase; Reviewed; Region: PRK09224 1064551011637 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1064551011638 tetramer interface [polypeptide binding]; other site 1064551011639 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551011640 catalytic residue [active] 1064551011641 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1064551011642 putative Ile/Val binding site [chemical binding]; other site 1064551011643 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1064551011644 putative Ile/Val binding site [chemical binding]; other site 1064551011645 Phage-related protein [Function unknown]; Region: COG4679 1064551011646 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 1064551011647 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551011648 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 1064551011649 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 1064551011650 putative dimerization interface [polypeptide binding]; other site 1064551011651 ketol-acid reductoisomerase; Validated; Region: PRK05225 1064551011652 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1064551011653 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1064551011654 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1064551011655 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 1064551011656 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1064551011657 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 1064551011658 Part of AAA domain; Region: AAA_19; pfam13245 1064551011659 Family description; Region: UvrD_C_2; pfam13538 1064551011660 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 1064551011661 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1064551011662 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1064551011663 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1064551011664 ATP binding site [chemical binding]; other site 1064551011665 Mg++ binding site [ion binding]; other site 1064551011666 motif III; other site 1064551011667 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1064551011668 nucleotide binding region [chemical binding]; other site 1064551011669 ATP-binding site [chemical binding]; other site 1064551011670 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1064551011671 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1064551011672 catalytic residues [active] 1064551011673 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1064551011674 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1064551011675 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1064551011676 RNA binding site [nucleotide binding]; other site 1064551011677 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1064551011678 multimer interface [polypeptide binding]; other site 1064551011679 Walker A motif; other site 1064551011680 ATP binding site [chemical binding]; other site 1064551011681 Walker B motif; other site 1064551011682 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 1064551011683 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1064551011684 Mg++ binding site [ion binding]; other site 1064551011685 putative catalytic motif [active] 1064551011686 substrate binding site [chemical binding]; other site 1064551011687 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 1064551011688 Chain length determinant protein; Region: Wzz; pfam02706 1064551011689 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1064551011690 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1064551011691 active site 1064551011692 homodimer interface [polypeptide binding]; other site 1064551011693 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 1064551011694 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1064551011695 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1064551011696 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 1064551011697 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1064551011698 NAD binding site [chemical binding]; other site 1064551011699 substrate binding site [chemical binding]; other site 1064551011700 homodimer interface [polypeptide binding]; other site 1064551011701 active site 1064551011702 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1064551011703 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1064551011704 substrate binding site; other site 1064551011705 tetramer interface; other site 1064551011706 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 1064551011707 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1064551011708 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1064551011709 inhibitor-cofactor binding pocket; inhibition site 1064551011710 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551011711 catalytic residue [active] 1064551011712 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1064551011713 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 1064551011714 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 1064551011715 putative common antigen polymerase; Provisional; Region: PRK02975 1064551011716 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1064551011717 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1064551011718 putative transport protein YifK; Provisional; Region: PRK10746 1064551011719 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 1064551011720 HemY protein N-terminus; Region: HemY_N; pfam07219 1064551011721 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1064551011722 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 1064551011723 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1064551011724 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1064551011725 active site 1064551011726 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1064551011727 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1064551011728 domain interfaces; other site 1064551011729 active site 1064551011730 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 1064551011731 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 1064551011732 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 1064551011733 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 1064551011734 putative iron binding site [ion binding]; other site 1064551011735 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 1064551011736 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 1064551011737 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1064551011738 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1064551011739 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1064551011740 hypothetical protein; Provisional; Region: PRK10963 1064551011741 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 1064551011742 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1064551011743 active site 1064551011744 Int/Topo IB signature motif; other site 1064551011745 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 1064551011746 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064551011747 motif II; other site 1064551011748 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1064551011749 Part of AAA domain; Region: AAA_19; pfam13245 1064551011750 Family description; Region: UvrD_C_2; pfam13538 1064551011751 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1064551011752 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 1064551011753 Cl binding site [ion binding]; other site 1064551011754 oligomer interface [polypeptide binding]; other site 1064551011755 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 1064551011756 EamA-like transporter family; Region: EamA; cl17759 1064551011757 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1064551011758 CoenzymeA binding site [chemical binding]; other site 1064551011759 subunit interaction site [polypeptide binding]; other site 1064551011760 PHB binding site; other site 1064551011761 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 1064551011762 dimerization interface [polypeptide binding]; other site 1064551011763 substrate binding site [chemical binding]; other site 1064551011764 active site 1064551011765 calcium binding site [ion binding]; other site 1064551011766 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 1064551011767 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1064551011768 ATP binding site [chemical binding]; other site 1064551011769 putative Mg++ binding site [ion binding]; other site 1064551011770 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1064551011771 nucleotide binding region [chemical binding]; other site 1064551011772 ATP-binding site [chemical binding]; other site 1064551011773 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1064551011774 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1064551011775 threonine efflux system; Provisional; Region: PRK10229 1064551011776 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 1064551011777 lysophospholipase L2; Provisional; Region: PRK10749 1064551011778 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1064551011779 putative hydrolase; Provisional; Region: PRK10976 1064551011780 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064551011781 active site 1064551011782 motif I; other site 1064551011783 motif II; other site 1064551011784 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064551011785 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1064551011786 EamA-like transporter family; Region: EamA; pfam00892 1064551011787 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 1064551011788 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551011789 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 1064551011790 putative dimerization interface [polypeptide binding]; other site 1064551011791 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1064551011792 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1064551011793 THF binding site; other site 1064551011794 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1064551011795 substrate binding site [chemical binding]; other site 1064551011796 THF binding site; other site 1064551011797 zinc-binding site [ion binding]; other site 1064551011798 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1064551011799 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064551011800 FeS/SAM binding site; other site 1064551011801 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1064551011802 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1064551011803 uridine phosphorylase; Provisional; Region: PRK11178 1064551011804 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 1064551011805 DNA recombination protein RmuC; Provisional; Region: PRK10361 1064551011806 RmuC family; Region: RmuC; pfam02646 1064551011807 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1064551011808 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064551011809 S-adenosylmethionine binding site [chemical binding]; other site 1064551011810 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 1064551011811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1064551011812 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1064551011813 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 1064551011814 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1064551011815 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 1064551011816 sec-independent translocase; Provisional; Region: PRK01770 1064551011817 sec-independent translocase; Provisional; Region: tatB; PRK00404 1064551011818 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 1064551011819 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1064551011820 active site 1064551011821 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 1064551011822 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 1064551011823 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 1064551011824 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 1064551011825 FMN reductase; Validated; Region: fre; PRK08051 1064551011826 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1064551011827 FAD binding pocket [chemical binding]; other site 1064551011828 FAD binding motif [chemical binding]; other site 1064551011829 phosphate binding motif [ion binding]; other site 1064551011830 beta-alpha-beta structure motif; other site 1064551011831 NAD binding pocket [chemical binding]; other site 1064551011832 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 1064551011833 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 1064551011834 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1064551011835 dimer interface [polypeptide binding]; other site 1064551011836 active site 1064551011837 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1064551011838 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1064551011839 substrate binding site [chemical binding]; other site 1064551011840 oxyanion hole (OAH) forming residues; other site 1064551011841 trimer interface [polypeptide binding]; other site 1064551011842 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1064551011843 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1064551011844 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1064551011845 proline dipeptidase; Provisional; Region: PRK13607 1064551011846 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1064551011847 active site 1064551011848 hypothetical protein; Provisional; Region: PRK11568 1064551011849 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1064551011850 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1064551011851 potassium transporter; Provisional; Region: PRK10750 1064551011852 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1064551011853 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 1064551011854 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1064551011855 Walker A motif; other site 1064551011856 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1064551011857 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1064551011858 GTP binding site; other site 1064551011859 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 1064551011860 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1064551011861 serine/threonine protein kinase; Provisional; Region: PRK11768 1064551011862 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1064551011863 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1064551011864 catalytic residues [active] 1064551011865 hinge region; other site 1064551011866 alpha helical domain; other site 1064551011867 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1064551011868 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1064551011869 putative acyl-acceptor binding pocket; other site 1064551011870 DNA polymerase I; Provisional; Region: PRK05755 1064551011871 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1064551011872 active site 1064551011873 metal binding site 1 [ion binding]; metal-binding site 1064551011874 putative 5' ssDNA interaction site; other site 1064551011875 metal binding site 3; metal-binding site 1064551011876 metal binding site 2 [ion binding]; metal-binding site 1064551011877 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1064551011878 putative DNA binding site [nucleotide binding]; other site 1064551011879 putative metal binding site [ion binding]; other site 1064551011880 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1064551011881 active site 1064551011882 catalytic site [active] 1064551011883 substrate binding site [chemical binding]; other site 1064551011884 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1064551011885 active site 1064551011886 DNA binding site [nucleotide binding] 1064551011887 catalytic site [active] 1064551011888 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1064551011889 G1 box; other site 1064551011890 GTP/Mg2+ binding site [chemical binding]; other site 1064551011891 Switch I region; other site 1064551011892 G2 box; other site 1064551011893 G3 box; other site 1064551011894 Switch II region; other site 1064551011895 G4 box; other site 1064551011896 G5 box; other site 1064551011897 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 1064551011898 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1064551011899 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064551011900 FeS/SAM binding site; other site 1064551011901 HemN C-terminal domain; Region: HemN_C; pfam06969 1064551011902 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 1064551011903 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064551011904 active site 1064551011905 phosphorylation site [posttranslational modification] 1064551011906 intermolecular recognition site; other site 1064551011907 dimerization interface [polypeptide binding]; other site 1064551011908 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064551011909 Walker A motif; other site 1064551011910 ATP binding site [chemical binding]; other site 1064551011911 Walker B motif; other site 1064551011912 arginine finger; other site 1064551011913 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1064551011914 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 1064551011915 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1064551011916 putative active site [active] 1064551011917 heme pocket [chemical binding]; other site 1064551011918 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064551011919 dimer interface [polypeptide binding]; other site 1064551011920 phosphorylation site [posttranslational modification] 1064551011921 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064551011922 ATP binding site [chemical binding]; other site 1064551011923 Mg2+ binding site [ion binding]; other site 1064551011924 G-X-G motif; other site 1064551011925 glutamine synthetase; Provisional; Region: glnA; PRK09469 1064551011926 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1064551011927 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1064551011928 GTP-binding protein; Provisional; Region: PRK10218 1064551011929 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1064551011930 G1 box; other site 1064551011931 putative GEF interaction site [polypeptide binding]; other site 1064551011932 GTP/Mg2+ binding site [chemical binding]; other site 1064551011933 Switch I region; other site 1064551011934 G2 box; other site 1064551011935 G3 box; other site 1064551011936 Switch II region; other site 1064551011937 G4 box; other site 1064551011938 G5 box; other site 1064551011939 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1064551011940 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1064551011941 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064551011942 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1064551011943 active site 1064551011944 motif I; other site 1064551011945 motif II; other site 1064551011946 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064551011947 coproporphyrinogen III oxidase; Validated; Region: PRK08208 1064551011948 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064551011949 FeS/SAM binding site; other site 1064551011950 HemN C-terminal domain; Region: HemN_C; pfam06969 1064551011951 Sulfatase; Region: Sulfatase; cl17466 1064551011952 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1064551011953 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1064551011954 Leucine-rich repeats; other site 1064551011955 Substrate binding site [chemical binding]; other site 1064551011956 outer membrane porin L; Provisional; Region: ompL; PRK09980 1064551011957 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1064551011958 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551011959 putative substrate translocation pore; other site 1064551011960 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1064551011961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551011962 putative substrate translocation pore; other site 1064551011963 alpha-glucosidase; Provisional; Region: PRK10426 1064551011964 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1064551011965 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 1064551011966 putative active site [active] 1064551011967 putative catalytic site [active] 1064551011968 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1064551011969 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 1064551011970 active site 1064551011971 catalytic residues [active] 1064551011972 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 1064551011973 dimerization interface [polypeptide binding]; other site 1064551011974 putative active cleft [active] 1064551011975 Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684 1064551011976 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 1064551011977 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1064551011978 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1064551011979 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 1064551011980 substrate binding site [chemical binding]; other site 1064551011981 ATP binding site [chemical binding]; other site 1064551011982 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1064551011983 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1064551011984 putative DNA binding site [nucleotide binding]; other site 1064551011985 putative Zn2+ binding site [ion binding]; other site 1064551011986 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1064551011987 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1064551011988 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064551011989 motif II; other site 1064551011990 hypothetical protein; Reviewed; Region: PRK01637 1064551011991 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1064551011992 putative active site [active] 1064551011993 dimerization interface [polypeptide binding]; other site 1064551011994 putative tRNAtyr binding site [nucleotide binding]; other site 1064551011995 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064551011996 Coenzyme A binding pocket [chemical binding]; other site 1064551011997 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 1064551011998 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064551011999 non-specific DNA binding site [nucleotide binding]; other site 1064551012000 salt bridge; other site 1064551012001 sequence-specific DNA binding site [nucleotide binding]; other site 1064551012002 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680 1064551012003 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1064551012004 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1064551012005 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 1064551012006 Predicted transcriptional regulator [Transcription]; Region: COG2944 1064551012007 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064551012008 non-specific DNA binding site [nucleotide binding]; other site 1064551012009 salt bridge; other site 1064551012010 sequence-specific DNA binding site [nucleotide binding]; other site 1064551012011 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 1064551012012 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1064551012013 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 1064551012014 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1064551012015 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1064551012016 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1064551012017 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1064551012018 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1064551012019 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1064551012020 molybdopterin cofactor binding site; other site 1064551012021 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1064551012022 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1064551012023 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 1064551012024 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 1064551012025 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1064551012026 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1064551012027 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064551012028 non-specific DNA binding site [nucleotide binding]; other site 1064551012029 salt bridge; other site 1064551012030 sequence-specific DNA binding site [nucleotide binding]; other site 1064551012031 Cupin domain; Region: Cupin_2; cl17218 1064551012032 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 1064551012033 lactaldehyde reductase; Region: lactal_redase; TIGR02638 1064551012034 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1064551012035 dimer interface [polypeptide binding]; other site 1064551012036 active site 1064551012037 metal binding site [ion binding]; metal-binding site 1064551012038 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1064551012039 intersubunit interface [polypeptide binding]; other site 1064551012040 active site 1064551012041 Zn2+ binding site [ion binding]; other site 1064551012042 L-rhamnose isomerase; Provisional; Region: PRK01076 1064551012043 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 1064551012044 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1064551012045 N- and C-terminal domain interface [polypeptide binding]; other site 1064551012046 active site 1064551012047 putative catalytic site [active] 1064551012048 metal binding site [ion binding]; metal-binding site 1064551012049 ATP binding site [chemical binding]; other site 1064551012050 rhamnulokinase; Provisional; Region: rhaB; PRK10640 1064551012051 carbohydrate binding site [chemical binding]; other site 1064551012052 transcriptional activator RhaS; Provisional; Region: PRK13503 1064551012053 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1064551012054 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064551012055 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064551012056 transcriptional activator RhaR; Provisional; Region: PRK13502 1064551012057 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1064551012058 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064551012059 L-rhamnose-proton symport protein (RhaT); Region: RhaT; pfam06379 1064551012060 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 1064551012061 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178 1064551012062 DctM-like transporters; Region: DctM; pfam06808 1064551012063 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1064551012064 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1064551012065 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1064551012066 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1064551012067 superoxide dismutase; Provisional; Region: PRK10925 1064551012068 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1064551012069 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1064551012070 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 1064551012071 MOSC domain; Region: MOSC; pfam03473 1064551012072 3-alpha domain; Region: 3-alpha; pfam03475 1064551012073 SnoaL-like domain; Region: SnoaL_2; pfam12680 1064551012074 two-component sensor protein; Provisional; Region: cpxA; PRK09470 1064551012075 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064551012076 dimerization interface [polypeptide binding]; other site 1064551012077 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064551012078 dimer interface [polypeptide binding]; other site 1064551012079 phosphorylation site [posttranslational modification] 1064551012080 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064551012081 ATP binding site [chemical binding]; other site 1064551012082 Mg2+ binding site [ion binding]; other site 1064551012083 G-X-G motif; other site 1064551012084 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 1064551012085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064551012086 active site 1064551012087 intermolecular recognition site; other site 1064551012088 dimerization interface [polypeptide binding]; other site 1064551012089 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1064551012090 DNA binding site [nucleotide binding] 1064551012091 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1064551012092 dimer interface [polypeptide binding]; other site 1064551012093 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 1064551012094 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1064551012095 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1064551012096 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1064551012097 active site 1064551012098 ADP/pyrophosphate binding site [chemical binding]; other site 1064551012099 dimerization interface [polypeptide binding]; other site 1064551012100 allosteric effector site; other site 1064551012101 fructose-1,6-bisphosphate binding site; other site 1064551012102 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1064551012103 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064551012104 substrate binding pocket [chemical binding]; other site 1064551012105 membrane-bound complex binding site; other site 1064551012106 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 1064551012107 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1064551012108 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1064551012109 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1064551012110 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1064551012111 putative substrate binding site [chemical binding]; other site 1064551012112 putative ATP binding site [chemical binding]; other site 1064551012113 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 1064551012114 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1064551012115 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064551012116 DNA-binding site [nucleotide binding]; DNA binding site 1064551012117 Alanine racemase, C-terminal domain; Region: Ala_racemase_C; cl08293 1064551012118 UTRA domain; Region: UTRA; pfam07702 1064551012119 CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934 1064551012120 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1064551012121 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 1064551012122 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 1064551012123 putative N- and C-terminal domain interface [polypeptide binding]; other site 1064551012124 putative active site [active] 1064551012125 putative MgATP binding site [chemical binding]; other site 1064551012126 catalytic site [active] 1064551012127 metal binding site [ion binding]; metal-binding site 1064551012128 putative carbohydrate binding site [chemical binding]; other site 1064551012129 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1064551012130 transcriptional regulator LsrR; Provisional; Region: PRK15418 1064551012131 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1064551012132 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1064551012133 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 1064551012134 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1064551012135 Walker A/P-loop; other site 1064551012136 ATP binding site [chemical binding]; other site 1064551012137 Q-loop/lid; other site 1064551012138 ABC transporter signature motif; other site 1064551012139 Walker B; other site 1064551012140 D-loop; other site 1064551012141 H-loop/switch region; other site 1064551012142 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1064551012143 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1064551012144 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1064551012145 TM-ABC transporter signature motif; other site 1064551012146 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 1064551012147 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1064551012148 ligand binding site [chemical binding]; other site 1064551012149 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1064551012150 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1064551012151 putative active site; other site 1064551012152 catalytic residue [active] 1064551012153 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 1064551012154 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1064551012155 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1064551012156 substrate binding site [chemical binding]; other site 1064551012157 hexamer interface [polypeptide binding]; other site 1064551012158 metal binding site [ion binding]; metal-binding site 1064551012159 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1064551012160 triosephosphate isomerase; Provisional; Region: PRK14567 1064551012161 substrate binding site [chemical binding]; other site 1064551012162 dimer interface [polypeptide binding]; other site 1064551012163 catalytic triad [active] 1064551012164 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 1064551012165 Predicted membrane protein [Function unknown]; Region: COG3152 1064551012166 ferredoxin-NADP reductase; Provisional; Region: PRK10926 1064551012167 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1064551012168 FAD binding pocket [chemical binding]; other site 1064551012169 FAD binding motif [chemical binding]; other site 1064551012170 phosphate binding motif [ion binding]; other site 1064551012171 beta-alpha-beta structure motif; other site 1064551012172 NAD binding pocket [chemical binding]; other site 1064551012173 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1064551012174 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1064551012175 putative active site [active] 1064551012176 glycerol kinase; Provisional; Region: glpK; PRK00047 1064551012177 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1064551012178 N- and C-terminal domain interface [polypeptide binding]; other site 1064551012179 active site 1064551012180 MgATP binding site [chemical binding]; other site 1064551012181 catalytic site [active] 1064551012182 metal binding site [ion binding]; metal-binding site 1064551012183 glycerol binding site [chemical binding]; other site 1064551012184 homotetramer interface [polypeptide binding]; other site 1064551012185 homodimer interface [polypeptide binding]; other site 1064551012186 FBP binding site [chemical binding]; other site 1064551012187 protein IIAGlc interface [polypeptide binding]; other site 1064551012188 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1064551012189 amphipathic channel; other site 1064551012190 Asn-Pro-Ala signature motifs; other site 1064551012191 septal ring assembly protein ZapB; Provisional; Region: PRK15422 1064551012192 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1064551012193 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 1064551012194 UbiA prenyltransferase family; Region: UbiA; pfam01040 1064551012195 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1064551012196 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064551012197 Walker A motif; other site 1064551012198 ATP binding site [chemical binding]; other site 1064551012199 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1064551012200 Walker B motif; other site 1064551012201 arginine finger; other site 1064551012202 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1064551012203 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1064551012204 active site 1064551012205 HslU subunit interaction site [polypeptide binding]; other site 1064551012206 essential cell division protein FtsN; Provisional; Region: PRK10927 1064551012207 cell division protein FtsN; Provisional; Region: PRK12757 1064551012208 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1064551012209 DNA binding site [nucleotide binding] 1064551012210 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 1064551012211 domain linker motif; other site 1064551012212 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 1064551012213 dimerization interface [polypeptide binding]; other site 1064551012214 ligand binding site [chemical binding]; other site 1064551012215 primosome assembly protein PriA; Validated; Region: PRK05580 1064551012216 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1064551012217 ATP binding site [chemical binding]; other site 1064551012218 putative Mg++ binding site [ion binding]; other site 1064551012219 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1064551012220 ATP-binding site [chemical binding]; other site 1064551012221 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1064551012222 conserved hypothetical protein; Region: chp_urease_rgn; TIGR02117 1064551012223 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 1064551012224 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 1064551012225 dimerization interface [polypeptide binding]; other site 1064551012226 DNA binding site [nucleotide binding] 1064551012227 corepressor binding sites; other site 1064551012228 cystathionine gamma-synthase; Provisional; Region: PRK08045 1064551012229 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1064551012230 homodimer interface [polypeptide binding]; other site 1064551012231 substrate-cofactor binding pocket; other site 1064551012232 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551012233 catalytic residue [active] 1064551012234 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 1064551012235 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1064551012236 putative catalytic residues [active] 1064551012237 putative nucleotide binding site [chemical binding]; other site 1064551012238 putative aspartate binding site [chemical binding]; other site 1064551012239 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 1064551012240 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1064551012241 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1064551012242 mechanosensitive channel MscS; Provisional; Region: PRK10334 1064551012243 Conserved TM helix; Region: TM_helix; pfam05552 1064551012244 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1064551012245 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1064551012246 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1064551012247 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1064551012248 active site 1064551012249 metal binding site [ion binding]; metal-binding site 1064551012250 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1064551012251 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1064551012252 FAD binding site [chemical binding]; other site 1064551012253 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1064551012254 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1064551012255 heme binding site [chemical binding]; other site 1064551012256 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1064551012257 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 1064551012258 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1064551012259 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1064551012260 dimer interface [polypeptide binding]; other site 1064551012261 active site 1064551012262 metal binding site [ion binding]; metal-binding site 1064551012263 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1064551012264 active site 1064551012265 intersubunit interactions; other site 1064551012266 catalytic residue [active] 1064551012267 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1064551012268 dimerization domain swap beta strand [polypeptide binding]; other site 1064551012269 regulatory protein interface [polypeptide binding]; other site 1064551012270 active site 1064551012271 regulatory phosphorylation site [posttranslational modification]; other site 1064551012272 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1064551012273 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1064551012274 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1064551012275 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1064551012276 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1064551012277 active site 1064551012278 phosphorylation site [posttranslational modification] 1064551012279 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 1064551012280 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1064551012281 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1064551012282 active site 1064551012283 P-loop; other site 1064551012284 phosphorylation site [posttranslational modification] 1064551012285 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 1064551012286 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1064551012287 dimer interface [polypeptide binding]; other site 1064551012288 active site 1064551012289 glycine loop; other site 1064551012290 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064551012291 FeS/SAM binding site; other site 1064551012292 pyruvate formate lyase II activase; Provisional; Region: PRK10076 1064551012293 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1064551012294 active site 1064551012295 P-loop; other site 1064551012296 phosphorylation site [posttranslational modification] 1064551012297 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1064551012298 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064551012299 hypothetical protein; Provisional; Region: PRK10649 1064551012300 Sulfatase; Region: Sulfatase; pfam00884 1064551012301 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1064551012302 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1064551012303 acetylornithine deacetylase; Provisional; Region: PRK05111 1064551012304 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1064551012305 metal binding site [ion binding]; metal-binding site 1064551012306 putative dimer interface [polypeptide binding]; other site 1064551012307 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1064551012308 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1064551012309 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 1064551012310 nucleotide binding site [chemical binding]; other site 1064551012311 N-acetyl-L-glutamate binding site [chemical binding]; other site 1064551012312 argininosuccinate lyase; Provisional; Region: PRK04833 1064551012313 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1064551012314 active sites [active] 1064551012315 tetramer interface [polypeptide binding]; other site 1064551012316 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1064551012317 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551012318 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1064551012319 dimerization interface [polypeptide binding]; other site 1064551012320 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1064551012321 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1064551012322 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1064551012323 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1064551012324 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1064551012325 hypothetical protein; Provisional; Region: PRK11056 1064551012326 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 1064551012327 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064551012328 S-adenosylmethionine binding site [chemical binding]; other site 1064551012329 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 1064551012330 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1064551012331 N-terminal plug; other site 1064551012332 ligand-binding site [chemical binding]; other site 1064551012333 glutamate racemase; Provisional; Region: PRK00865 1064551012334 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1064551012335 FAD binding domain; Region: FAD_binding_4; pfam01565 1064551012336 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1064551012337 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1064551012338 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1064551012339 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1064551012340 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1064551012341 pantothenate kinase; Provisional; Region: PRK05439 1064551012342 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1064551012343 ATP-binding site [chemical binding]; other site 1064551012344 CoA-binding site [chemical binding]; other site 1064551012345 Mg2+-binding site [ion binding]; other site 1064551012346 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1064551012347 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1064551012348 Antibiotic Binding Site [chemical binding]; other site 1064551012349 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1064551012350 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1064551012351 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1064551012352 putative homodimer interface [polypeptide binding]; other site 1064551012353 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1064551012354 heterodimer interface [polypeptide binding]; other site 1064551012355 homodimer interface [polypeptide binding]; other site 1064551012356 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1064551012357 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1064551012358 23S rRNA interface [nucleotide binding]; other site 1064551012359 L7/L12 interface [polypeptide binding]; other site 1064551012360 putative thiostrepton binding site; other site 1064551012361 L25 interface [polypeptide binding]; other site 1064551012362 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1064551012363 mRNA/rRNA interface [nucleotide binding]; other site 1064551012364 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1064551012365 23S rRNA interface [nucleotide binding]; other site 1064551012366 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1064551012367 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1064551012368 core dimer interface [polypeptide binding]; other site 1064551012369 peripheral dimer interface [polypeptide binding]; other site 1064551012370 L10 interface [polypeptide binding]; other site 1064551012371 L11 interface [polypeptide binding]; other site 1064551012372 putative EF-Tu interaction site [polypeptide binding]; other site 1064551012373 putative EF-G interaction site [polypeptide binding]; other site 1064551012374 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1064551012375 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1064551012376 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1064551012377 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1064551012378 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1064551012379 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1064551012380 RPB3 interaction site [polypeptide binding]; other site 1064551012381 RPB1 interaction site [polypeptide binding]; other site 1064551012382 RPB11 interaction site [polypeptide binding]; other site 1064551012383 RPB10 interaction site [polypeptide binding]; other site 1064551012384 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1064551012385 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1064551012386 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1064551012387 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1064551012388 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1064551012389 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1064551012390 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1064551012391 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1064551012392 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1064551012393 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1064551012394 DNA binding site [nucleotide binding] 1064551012395 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1064551012396 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 1064551012397 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064551012398 FeS/SAM binding site; other site 1064551012399 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1064551012400 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1064551012401 ThiS interaction site; other site 1064551012402 putative active site [active] 1064551012403 tetramer interface [polypeptide binding]; other site 1064551012404 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1064551012405 thiS-thiF/thiG interaction site; other site 1064551012406 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1064551012407 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 1064551012408 ATP binding site [chemical binding]; other site 1064551012409 substrate interface [chemical binding]; other site 1064551012410 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1064551012411 thiamine phosphate binding site [chemical binding]; other site 1064551012412 active site 1064551012413 pyrophosphate binding site [ion binding]; other site 1064551012414 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1064551012415 ThiC-associated domain; Region: ThiC-associated; pfam13667 1064551012416 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1064551012417 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 1064551012418 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1064551012419 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1064551012420 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1064551012421 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1064551012422 putative NADH binding site [chemical binding]; other site 1064551012423 putative active site [active] 1064551012424 nudix motif; other site 1064551012425 putative metal binding site [ion binding]; other site 1064551012426 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1064551012427 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1064551012428 substrate binding site [chemical binding]; other site 1064551012429 active site 1064551012430 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1064551012431 Active_site [active] 1064551012432 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 1064551012433 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1064551012434 IHF dimer interface [polypeptide binding]; other site 1064551012435 IHF - DNA interface [nucleotide binding]; other site 1064551012436 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 1064551012437 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1064551012438 dimer interface [polypeptide binding]; other site 1064551012439 sensor protein ZraS; Provisional; Region: PRK10364 1064551012440 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064551012441 dimer interface [polypeptide binding]; other site 1064551012442 phosphorylation site [posttranslational modification] 1064551012443 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064551012444 ATP binding site [chemical binding]; other site 1064551012445 Mg2+ binding site [ion binding]; other site 1064551012446 G-X-G motif; other site 1064551012447 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 1064551012448 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064551012449 active site 1064551012450 phosphorylation site [posttranslational modification] 1064551012451 intermolecular recognition site; other site 1064551012452 dimerization interface [polypeptide binding]; other site 1064551012453 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064551012454 Walker A motif; other site 1064551012455 ATP binding site [chemical binding]; other site 1064551012456 Walker B motif; other site 1064551012457 arginine finger; other site 1064551012458 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1064551012459 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1064551012460 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1064551012461 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1064551012462 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1064551012463 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1064551012464 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1064551012465 purine monophosphate binding site [chemical binding]; other site 1064551012466 dimer interface [polypeptide binding]; other site 1064551012467 putative catalytic residues [active] 1064551012468 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1064551012469 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1064551012470 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064551012471 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1064551012472 Coenzyme A binding pocket [chemical binding]; other site 1064551012473 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1064551012474 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1064551012475 proposed active site lysine [active] 1064551012476 conserved cys residue [active] 1064551012477 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 1064551012478 malate synthase A; Region: malate_syn_A; TIGR01344 1064551012479 active site 1064551012480 isocitrate lyase; Provisional; Region: PRK15063 1064551012481 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1064551012482 tetramer interface [polypeptide binding]; other site 1064551012483 active site 1064551012484 Mg2+/Mn2+ binding site [ion binding]; other site 1064551012485 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 1064551012486 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 1064551012487 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1064551012488 transcriptional repressor IclR; Provisional; Region: PRK11569 1064551012489 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1064551012490 Bacterial transcriptional regulator; Region: IclR; pfam01614 1064551012491 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1064551012492 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1064551012493 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1064551012494 substrate binding pocket [chemical binding]; other site 1064551012495 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1064551012496 B12 binding site [chemical binding]; other site 1064551012497 cobalt ligand [ion binding]; other site 1064551012498 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1064551012499 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1064551012500 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1064551012501 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1064551012502 active site pocket [active] 1064551012503 oxyanion hole [active] 1064551012504 catalytic triad [active] 1064551012505 active site nucleophile [active] 1064551012506 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 1064551012507 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 1064551012508 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1064551012509 RNA binding surface [nucleotide binding]; other site 1064551012510 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 1064551012511 probable active site [active] 1064551012512 hypothetical protein; Provisional; Region: PRK10515 1064551012513 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1064551012514 Sodium Bile acid symporter family; Region: SBF; pfam01758 1064551012515 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 1064551012516 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 1064551012517 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1064551012518 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1064551012519 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 1064551012520 Phage-related baseplate assembly protein [General function prediction only]; Region: COG3948 1064551012521 Phage baseplate assembly protein W [General function prediction only]; Region: COG3628 1064551012522 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1064551012523 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1064551012524 Ligand binding site; other site 1064551012525 Putative Catalytic site; other site 1064551012526 DXD motif; other site 1064551012527 Predicted membrane protein [Function unknown]; Region: COG2246 1064551012528 GtrA-like protein; Region: GtrA; pfam04138 1064551012529 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1064551012530 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 1064551012531 Phage protein D [General function prediction only]; Region: COG3500 1064551012532 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 1064551012533 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 1064551012534 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 1064551012535 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 1064551012536 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1064551012537 Phage tail tube protein FII [General function prediction only]; Region: COG3498 1064551012538 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 1064551012539 Gp37 protein; Region: Gp37; pfam09646 1064551012540 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1064551012541 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1064551012542 catalytic residue [active] 1064551012543 Protein of unknown function (DUF4063); Region: DUF4063; pfam13272 1064551012544 Mor transcription activator family; Region: Mor; pfam08765 1064551012545 aspartate kinase III; Validated; Region: PRK09084 1064551012546 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1064551012547 nucleotide binding site [chemical binding]; other site 1064551012548 substrate binding site [chemical binding]; other site 1064551012549 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1064551012550 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 1064551012551 dimer interface [polypeptide binding]; other site 1064551012552 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1064551012553 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1064551012554 active site 1064551012555 dimer interface [polypeptide binding]; other site 1064551012556 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1064551012557 dimer interface [polypeptide binding]; other site 1064551012558 active site 1064551012559 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 1064551012560 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 1064551012561 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 1064551012562 Predicted membrane protein [Function unknown]; Region: COG3223 1064551012563 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1064551012564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551012565 dimer interface [polypeptide binding]; other site 1064551012566 conserved gate region; other site 1064551012567 putative PBP binding loops; other site 1064551012568 ABC-ATPase subunit interface; other site 1064551012569 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1064551012570 dimer interface [polypeptide binding]; other site 1064551012571 conserved gate region; other site 1064551012572 putative PBP binding loops; other site 1064551012573 ABC-ATPase subunit interface; other site 1064551012574 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 1064551012575 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1064551012576 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1064551012577 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 1064551012578 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1064551012579 Walker A/P-loop; other site 1064551012580 ATP binding site [chemical binding]; other site 1064551012581 Q-loop/lid; other site 1064551012582 ABC transporter signature motif; other site 1064551012583 Walker B; other site 1064551012584 D-loop; other site 1064551012585 H-loop/switch region; other site 1064551012586 TOBE domain; Region: TOBE_2; pfam08402 1064551012587 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1064551012588 trimer interface; other site 1064551012589 sugar binding site [chemical binding]; other site 1064551012590 maltose regulon periplasmic protein; Provisional; Region: PRK10564 1064551012591 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 1064551012592 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1064551012593 UbiA prenyltransferase family; Region: UbiA; pfam01040 1064551012594 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 1064551012595 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1064551012596 putative acyl-acceptor binding pocket; other site 1064551012597 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1064551012598 LexA repressor; Validated; Region: PRK00215 1064551012599 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1064551012600 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1064551012601 Catalytic site [active] 1064551012602 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 1064551012603 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1064551012604 hypothetical protein; Provisional; Region: PRK10428 1064551012605 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1064551012606 metal binding site 2 [ion binding]; metal-binding site 1064551012607 putative DNA binding helix; other site 1064551012608 metal binding site 1 [ion binding]; metal-binding site 1064551012609 dimer interface [polypeptide binding]; other site 1064551012610 structural Zn2+ binding site [ion binding]; other site 1064551012611 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 1064551012612 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1064551012613 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1064551012614 FMN binding site [chemical binding]; other site 1064551012615 active site 1064551012616 catalytic residues [active] 1064551012617 substrate binding site [chemical binding]; other site 1064551012618 phage shock protein G; Reviewed; Region: pspG; PRK09459 1064551012619 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1064551012620 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1064551012621 NADP binding site [chemical binding]; other site 1064551012622 dimer interface [polypeptide binding]; other site 1064551012623 replicative DNA helicase; Provisional; Region: PRK08006 1064551012624 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1064551012625 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1064551012626 Walker A motif; other site 1064551012627 ATP binding site [chemical binding]; other site 1064551012628 Walker B motif; other site 1064551012629 DNA binding loops [nucleotide binding] 1064551012630 alanine racemase; Reviewed; Region: alr; PRK00053 1064551012631 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1064551012632 active site 1064551012633 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1064551012634 substrate binding site [chemical binding]; other site 1064551012635 catalytic residues [active] 1064551012636 dimer interface [polypeptide binding]; other site 1064551012637 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1064551012638 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1064551012639 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551012640 homodimer interface [polypeptide binding]; other site 1064551012641 catalytic residue [active] 1064551012642 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1064551012643 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064551012644 active site 1064551012645 motif I; other site 1064551012646 motif II; other site 1064551012647 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1064551012648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1064551012649 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1064551012650 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1064551012651 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1064551012652 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1064551012653 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1064551012654 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1064551012655 dimer interface [polypeptide binding]; other site 1064551012656 ssDNA binding site [nucleotide binding]; other site 1064551012657 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1064551012658 hypothetical protein; Validated; Region: PRK09039 1064551012659 Zinc finger-containing protein; Region: zf-C4H2; pfam10146 1064551012660 Outer membrane efflux protein; Region: OEP; pfam02321 1064551012661 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1064551012662 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1064551012663 HlyD family secretion protein; Region: HlyD_3; pfam13437 1064551012664 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1064551012665 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064551012666 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064551012667 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064551012668 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064551012669 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064551012670 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1064551012671 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1064551012672 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064551012673 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1064551012674 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064551012675 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1064551012676 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1064551012677 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064551012678 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1064551012679 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1064551012680 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064551012681 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1064551012682 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064551012683 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1064551012684 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1064551012685 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064551012686 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1064551012687 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064551012688 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064551012689 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064551012690 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064551012691 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1064551012692 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064551012693 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064551012694 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064551012695 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064551012696 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064551012697 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064551012698 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1064551012699 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064551012700 Bacterial Ig-like domain (group 3); Region: Big_3_2; pfam12245 1064551012701 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064551012702 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1064551012703 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1064551012704 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1064551012705 Walker A/P-loop; other site 1064551012706 ATP binding site [chemical binding]; other site 1064551012707 Q-loop/lid; other site 1064551012708 ABC transporter signature motif; other site 1064551012709 Walker B; other site 1064551012710 D-loop; other site 1064551012711 H-loop/switch region; other site 1064551012712 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1064551012713 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1064551012714 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1064551012715 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1064551012716 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064551012717 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 1064551012718 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 1064551012719 DNA binding residues [nucleotide binding] 1064551012720 dimer interface [polypeptide binding]; other site 1064551012721 [2Fe-2S] cluster binding site [ion binding]; other site 1064551012722 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1064551012723 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1064551012724 putative C-terminal domain interface [polypeptide binding]; other site 1064551012725 putative GSH binding site (G-site) [chemical binding]; other site 1064551012726 putative dimer interface [polypeptide binding]; other site 1064551012727 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 1064551012728 putative N-terminal domain interface [polypeptide binding]; other site 1064551012729 putative dimer interface [polypeptide binding]; other site 1064551012730 putative substrate binding pocket (H-site) [chemical binding]; other site 1064551012731 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1064551012732 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1064551012733 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1064551012734 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1064551012735 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551012736 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1064551012737 putative dimerization interface [polypeptide binding]; other site 1064551012738 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1064551012739 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1064551012740 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1064551012741 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1064551012742 Na binding site [ion binding]; other site 1064551012743 Predicted membrane protein [Function unknown]; Region: COG3162 1064551012744 acetyl-CoA synthetase; Provisional; Region: PRK00174 1064551012745 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1064551012746 active site 1064551012747 CoA binding site [chemical binding]; other site 1064551012748 acyl-activating enzyme (AAE) consensus motif; other site 1064551012749 AMP binding site [chemical binding]; other site 1064551012750 acetate binding site [chemical binding]; other site 1064551012751 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 1064551012752 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 1064551012753 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 1064551012754 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 1064551012755 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 1064551012756 heme lyase subunit NrfE; Provisional; Region: PRK10369 1064551012757 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 1064551012758 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 1064551012759 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 1064551012760 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1064551012761 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1064551012762 Sel1-like repeats; Region: SEL1; smart00671 1064551012763 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1064551012764 molybdopterin cofactor binding site; other site 1064551012765 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 1064551012766 molybdopterin cofactor binding site; other site 1064551012767 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1064551012768 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 1064551012769 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064551012770 Coenzyme A binding pocket [chemical binding]; other site 1064551012771 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1064551012772 dimer interface [polypeptide binding]; other site 1064551012773 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1064551012774 hypothetical protein; Provisional; Region: PRK10220 1064551012775 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1064551012776 PhnA protein; Region: PhnA; pfam03831 1064551012777 proline/glycine betaine transporter; Provisional; Region: PRK10642 1064551012778 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551012779 putative substrate translocation pore; other site 1064551012780 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 1064551012781 sensor protein BasS/PmrB; Provisional; Region: PRK10755 1064551012782 HAMP domain; Region: HAMP; pfam00672 1064551012783 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064551012784 dimer interface [polypeptide binding]; other site 1064551012785 phosphorylation site [posttranslational modification] 1064551012786 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064551012787 ATP binding site [chemical binding]; other site 1064551012788 Mg2+ binding site [ion binding]; other site 1064551012789 G-X-G motif; other site 1064551012790 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1064551012791 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064551012792 active site 1064551012793 phosphorylation site [posttranslational modification] 1064551012794 intermolecular recognition site; other site 1064551012795 dimerization interface [polypeptide binding]; other site 1064551012796 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1064551012797 DNA binding site [nucleotide binding] 1064551012798 putative metal dependent hydrolase; Provisional; Region: PRK11598 1064551012799 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1064551012800 Sulfatase; Region: Sulfatase; pfam00884 1064551012801 arginine:agmatin antiporter; Provisional; Region: PRK10644 1064551012802 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 1064551012803 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064551012804 arginine decarboxylase; Provisional; Region: PRK15029 1064551012805 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1064551012806 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1064551012807 homodimer interface [polypeptide binding]; other site 1064551012808 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1064551012809 catalytic residue [active] 1064551012810 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1064551012811 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 1064551012812 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064551012813 alpha-galactosidase; Provisional; Region: PRK15076 1064551012814 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1064551012815 NAD binding site [chemical binding]; other site 1064551012816 sugar binding site [chemical binding]; other site 1064551012817 divalent metal binding site [ion binding]; other site 1064551012818 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1064551012819 dimer interface [polypeptide binding]; other site 1064551012820 melibiose:sodium symporter; Provisional; Region: PRK10429 1064551012821 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1064551012822 fumarate hydratase; Provisional; Region: PRK15389 1064551012823 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 1064551012824 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1064551012825 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1064551012826 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 1064551012827 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 1064551012828 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064551012829 active site 1064551012830 phosphorylation site [posttranslational modification] 1064551012831 intermolecular recognition site; other site 1064551012832 dimerization interface [polypeptide binding]; other site 1064551012833 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1064551012834 PAS domain; Region: PAS; smart00091 1064551012835 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064551012836 ATP binding site [chemical binding]; other site 1064551012837 Mg2+ binding site [ion binding]; other site 1064551012838 G-X-G motif; other site 1064551012839 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1064551012840 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1064551012841 putative [Fe4-S4] binding site [ion binding]; other site 1064551012842 putative molybdopterin cofactor binding site [chemical binding]; other site 1064551012843 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1064551012844 putative molybdopterin cofactor binding site; other site 1064551012845 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1064551012846 DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302 1064551012847 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 1064551012848 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 1064551012849 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 1064551012850 SdiA-regulated; Region: SdiA-regulated; cd09971 1064551012851 putative active site [active] 1064551012852 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1064551012853 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064551012854 DNA binding residues [nucleotide binding] 1064551012855 dimerization interface [polypeptide binding]; other site 1064551012856 AraC family transcriptional regulator; Provisional; Region: PRK15186 1064551012857 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064551012858 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 1064551012859 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1064551012860 MULE transposase domain; Region: MULE; pfam10551 1064551012861 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1064551012862 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1064551012863 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 1064551012864 active site 1064551012865 putative transcriptional regulator; Provisional; Region: PRK11640 1064551012866 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1064551012867 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1064551012868 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1064551012869 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1064551012870 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1064551012871 DsbD alpha interface [polypeptide binding]; other site 1064551012872 catalytic residues [active] 1064551012873 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 1064551012874 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1064551012875 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1064551012876 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1064551012877 Aspartase; Region: Aspartase; cd01357 1064551012878 active sites [active] 1064551012879 tetramer interface [polypeptide binding]; other site 1064551012880 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 1064551012881 putative transporter; Provisional; Region: PRK11021 1064551012882 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1064551012883 oligomerisation interface [polypeptide binding]; other site 1064551012884 mobile loop; other site 1064551012885 roof hairpin; other site 1064551012886 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1064551012887 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1064551012888 ring oligomerisation interface [polypeptide binding]; other site 1064551012889 ATP/Mg binding site [chemical binding]; other site 1064551012890 stacking interactions; other site 1064551012891 hinge regions; other site 1064551012892 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 1064551012893 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1064551012894 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064551012895 FeS/SAM binding site; other site 1064551012896 elongation factor P; Validated; Region: PRK00529 1064551012897 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1064551012898 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1064551012899 RNA binding site [nucleotide binding]; other site 1064551012900 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1064551012901 RNA binding site [nucleotide binding]; other site 1064551012902 Predicted small secreted protein [Function unknown]; Region: COG5510 1064551012903 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 1064551012904 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1064551012905 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064551012906 DNA binding residues [nucleotide binding] 1064551012907 dimerization interface [polypeptide binding]; other site 1064551012908 multidrug efflux system protein; Provisional; Region: PRK11431 1064551012909 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 1064551012910 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1064551012911 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 1064551012912 Iron-sulfur protein interface; other site 1064551012913 proximal quinone binding site [chemical binding]; other site 1064551012914 C-subunit interface; other site 1064551012915 distal quinone binding site; other site 1064551012916 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 1064551012917 D-subunit interface [polypeptide binding]; other site 1064551012918 Iron-sulfur protein interface; other site 1064551012919 proximal quinone binding site [chemical binding]; other site 1064551012920 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 1064551012921 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1064551012922 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 1064551012923 L-aspartate oxidase; Provisional; Region: PRK06175 1064551012924 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1064551012925 poxB regulator PoxA; Provisional; Region: PRK09350 1064551012926 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1064551012927 motif 1; other site 1064551012928 dimer interface [polypeptide binding]; other site 1064551012929 active site 1064551012930 motif 2; other site 1064551012931 motif 3; other site 1064551012932 inner membrane transporter YjeM; Provisional; Region: PRK15238 1064551012933 Protein of unknown function (DUF2645); Region: DUF2645; pfam10840 1064551012934 putative mechanosensitive channel protein; Provisional; Region: PRK10929 1064551012935 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1064551012936 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1064551012937 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1064551012938 GTPase RsgA; Reviewed; Region: PRK12288 1064551012939 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1064551012940 RNA binding site [nucleotide binding]; other site 1064551012941 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1064551012942 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1064551012943 GTP/Mg2+ binding site [chemical binding]; other site 1064551012944 G4 box; other site 1064551012945 G5 box; other site 1064551012946 G1 box; other site 1064551012947 Switch I region; other site 1064551012948 G2 box; other site 1064551012949 G3 box; other site 1064551012950 Switch II region; other site 1064551012951 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1064551012952 catalytic site [active] 1064551012953 putative active site [active] 1064551012954 putative substrate binding site [chemical binding]; other site 1064551012955 dimer interface [polypeptide binding]; other site 1064551012956 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1064551012957 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1064551012958 substrate binding pocket [chemical binding]; other site 1064551012959 membrane-bound complex binding site; other site 1064551012960 hinge residues; other site 1064551012961 epoxyqueuosine reductase; Region: TIGR00276 1064551012962 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1064551012963 putative carbohydrate kinase; Provisional; Region: PRK10565 1064551012964 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1064551012965 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1064551012966 putative substrate binding site [chemical binding]; other site 1064551012967 putative ATP binding site [chemical binding]; other site 1064551012968 ADP-binding protein; Provisional; Region: PRK10646 1064551012969 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 1064551012970 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1064551012971 active site 1064551012972 metal binding site [ion binding]; metal-binding site 1064551012973 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1064551012974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064551012975 ATP binding site [chemical binding]; other site 1064551012976 Mg2+ binding site [ion binding]; other site 1064551012977 G-X-G motif; other site 1064551012978 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1064551012979 ATP binding site [chemical binding]; other site 1064551012980 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1064551012981 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1064551012982 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1064551012983 bacterial Hfq-like; Region: Hfq; cd01716 1064551012984 hexamer interface [polypeptide binding]; other site 1064551012985 Sm1 motif; other site 1064551012986 RNA binding site [nucleotide binding]; other site 1064551012987 Sm2 motif; other site 1064551012988 GTPase HflX; Provisional; Region: PRK11058 1064551012989 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1064551012990 HflX GTPase family; Region: HflX; cd01878 1064551012991 G1 box; other site 1064551012992 GTP/Mg2+ binding site [chemical binding]; other site 1064551012993 Switch I region; other site 1064551012994 G2 box; other site 1064551012995 G3 box; other site 1064551012996 Switch II region; other site 1064551012997 G4 box; other site 1064551012998 G5 box; other site 1064551012999 FtsH protease regulator HflK; Provisional; Region: PRK10930 1064551013000 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 1064551013001 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1064551013002 FtsH protease regulator HflC; Provisional; Region: PRK11029 1064551013003 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1064551013004 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 1064551013005 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1064551013006 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1064551013007 GDP-binding site [chemical binding]; other site 1064551013008 ACT binding site; other site 1064551013009 IMP binding site; other site 1064551013010 Predicted transcriptional regulator [Transcription]; Region: COG1959 1064551013011 transcriptional repressor NsrR; Provisional; Region: PRK11014 1064551013012 exoribonuclease R; Provisional; Region: PRK11642 1064551013013 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1064551013014 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1064551013015 RNB domain; Region: RNB; pfam00773 1064551013016 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1064551013017 RNA binding site [nucleotide binding]; other site 1064551013018 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1064551013019 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1064551013020 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1064551013021 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 1064551013022 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1064551013023 Ion channel; Region: Ion_trans_2; pfam07885 1064551013024 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1064551013025 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 1064551013026 Predicted membrane protein [Function unknown]; Region: COG3766 1064551013027 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1064551013028 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1064551013029 Predicted integral membrane protein [Function unknown]; Region: COG5463 1064551013030 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1064551013031 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1064551013032 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 1064551013033 FAD binding site [chemical binding]; other site 1064551013034 substrate binding site [chemical binding]; other site 1064551013035 catalytic residues [active] 1064551013036 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1064551013037 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 1064551013038 esterase; Provisional; Region: PRK10566 1064551013039 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1064551013040 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1064551013041 transcriptional repressor UlaR; Provisional; Region: PRK13509 1064551013042 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1064551013043 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1064551013044 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 1064551013045 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1064551013046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 1064551013047 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 1064551013048 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1064551013049 active site 1064551013050 P-loop; other site 1064551013051 phosphorylation site [posttranslational modification] 1064551013052 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1064551013053 active site 1064551013054 phosphorylation site [posttranslational modification] 1064551013055 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1064551013056 active site 1064551013057 dimer interface [polypeptide binding]; other site 1064551013058 magnesium binding site [ion binding]; other site 1064551013059 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 1064551013060 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1064551013061 AP (apurinic/apyrimidinic) site pocket; other site 1064551013062 DNA interaction; other site 1064551013063 Metal-binding active site; metal-binding site 1064551013064 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1064551013065 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1064551013066 intersubunit interface [polypeptide binding]; other site 1064551013067 active site 1064551013068 Zn2+ binding site [ion binding]; other site 1064551013069 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1064551013070 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1064551013071 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1064551013072 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1064551013073 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1064551013074 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1064551013075 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1064551013076 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1064551013077 EamA-like transporter family; Region: EamA; pfam00892 1064551013078 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 1064551013079 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 1064551013080 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 1064551013081 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1064551013082 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1064551013083 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1064551013084 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 1064551013085 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1064551013086 Hemerythrin-like domain; Region: Hr-like; cd12108 1064551013087 Fe binding site [ion binding]; other site 1064551013088 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1064551013089 EamA-like transporter family; Region: EamA; pfam00892 1064551013090 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1064551013091 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1064551013092 NADP binding site [chemical binding]; other site 1064551013093 Predicted transcriptional regulators [Transcription]; Region: COG1733 1064551013094 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1064551013095 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 1064551013096 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1064551013097 active site 1064551013098 metal binding site [ion binding]; metal-binding site 1064551013099 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1064551013100 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1064551013101 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1064551013102 active site 1064551013103 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 1064551013104 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 1064551013105 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1064551013106 Domain of unknown function DUF21; Region: DUF21; pfam01595 1064551013107 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1064551013108 Transporter associated domain; Region: CorC_HlyC; smart01091 1064551013109 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1064551013110 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1064551013111 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1064551013112 Surface antigen; Region: Bac_surface_Ag; pfam01103 1064551013113 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1064551013114 Family of unknown function (DUF490); Region: DUF490; pfam04357 1064551013115 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1064551013116 putative active site pocket [active] 1064551013117 dimerization interface [polypeptide binding]; other site 1064551013118 putative catalytic residue [active] 1064551013119 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551013120 D-galactonate transporter; Region: 2A0114; TIGR00893 1064551013121 putative substrate translocation pore; other site 1064551013122 putative metallo-dependent hydrolase; Provisional; Region: PRK12394 1064551013123 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 1064551013124 active site 1064551013125 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1064551013126 dimer interface [polypeptide binding]; other site 1064551013127 substrate binding site [chemical binding]; other site 1064551013128 metal binding sites [ion binding]; metal-binding site 1064551013129 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1064551013130 AMP binding site [chemical binding]; other site 1064551013131 metal binding site [ion binding]; metal-binding site 1064551013132 active site 1064551013133 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1064551013134 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1064551013135 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1064551013136 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1064551013137 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1064551013138 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1064551013139 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1064551013140 putative active site [active] 1064551013141 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1064551013142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551013143 putative substrate translocation pore; other site 1064551013144 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551013145 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1064551013146 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551013147 putative substrate translocation pore; other site 1064551013148 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551013149 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 1064551013150 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1064551013151 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1064551013152 tetrameric interface [polypeptide binding]; other site 1064551013153 NAD binding site [chemical binding]; other site 1064551013154 catalytic residues [active] 1064551013155 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1064551013156 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1064551013157 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064551013158 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1064551013159 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1064551013160 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1064551013161 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1064551013162 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1064551013163 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1064551013164 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1064551013165 major facilitator superfamily transporter; Provisional; Region: PRK05122 1064551013166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551013167 putative substrate translocation pore; other site 1064551013168 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1064551013169 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1064551013170 substrate binding site [chemical binding]; other site 1064551013171 ATP binding site [chemical binding]; other site 1064551013172 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 1064551013173 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 1064551013174 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1064551013175 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1064551013176 PYR/PP interface [polypeptide binding]; other site 1064551013177 dimer interface [polypeptide binding]; other site 1064551013178 TPP binding site [chemical binding]; other site 1064551013179 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1064551013180 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1064551013181 TPP-binding site; other site 1064551013182 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1064551013183 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1064551013184 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1064551013185 polyol permease family; Region: 2A0118; TIGR00897 1064551013186 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551013187 putative substrate translocation pore; other site 1064551013188 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 1064551013189 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1064551013190 DNA interaction; other site 1064551013191 Metal-binding active site; metal-binding site 1064551013192 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1064551013193 hypothetical protein; Provisional; Region: PRK05255 1064551013194 peptidase PmbA; Provisional; Region: PRK11040 1064551013195 cytochrome b562; Provisional; Region: PRK15058 1064551013196 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 1064551013197 conserved hypothetical protein EF_0830/AHA_3911; Region: EF_0830; TIGR03577 1064551013198 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 1064551013199 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 1064551013200 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 1064551013201 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 1064551013202 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 1064551013203 active site 1064551013204 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 1064551013205 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1064551013206 HTH domain; Region: HTH_11; pfam08279 1064551013207 Mga helix-turn-helix domain; Region: Mga; pfam05043 1064551013208 PRD domain; Region: PRD; pfam00874 1064551013209 PRD domain; Region: PRD; pfam00874 1064551013210 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1064551013211 active site 1064551013212 P-loop; other site 1064551013213 phosphorylation site [posttranslational modification] 1064551013214 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1064551013215 active site 1064551013216 phosphorylation site [posttranslational modification] 1064551013217 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 1064551013218 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1064551013219 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 1064551013220 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064551013221 FeS/SAM binding site; other site 1064551013222 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1064551013223 ATP cone domain; Region: ATP-cone; pfam03477 1064551013224 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1064551013225 effector binding site; other site 1064551013226 active site 1064551013227 Zn binding site [ion binding]; other site 1064551013228 glycine loop; other site 1064551013229 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 1064551013230 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1064551013231 Ca binding site [ion binding]; other site 1064551013232 active site 1064551013233 catalytic site [active] 1064551013234 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1064551013235 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 1064551013236 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1064551013237 active site turn [active] 1064551013238 phosphorylation site [posttranslational modification] 1064551013239 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1064551013240 trehalose repressor; Provisional; Region: treR; PRK09492 1064551013241 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1064551013242 DNA binding site [nucleotide binding] 1064551013243 domain linker motif; other site 1064551013244 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 1064551013245 dimerization interface [polypeptide binding]; other site 1064551013246 ligand binding site [chemical binding]; other site 1064551013247 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 1064551013248 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1064551013249 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1064551013250 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1064551013251 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1064551013252 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1064551013253 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1064551013254 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1064551013255 homotrimer interaction site [polypeptide binding]; other site 1064551013256 putative active site [active] 1064551013257 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 1064551013258 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 1064551013259 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 1064551013260 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 1064551013261 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1064551013262 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1064551013263 Arginine repressor [Transcription]; Region: ArgR; COG1438 1064551013264 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1064551013265 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1064551013266 Predicted membrane protein [Function unknown]; Region: COG1288 1064551013267 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1064551013268 ornithine carbamoyltransferase; Validated; Region: PRK02102 1064551013269 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1064551013270 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1064551013271 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1064551013272 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1064551013273 putative substrate binding site [chemical binding]; other site 1064551013274 nucleotide binding site [chemical binding]; other site 1064551013275 nucleotide binding site [chemical binding]; other site 1064551013276 homodimer interface [polypeptide binding]; other site 1064551013277 arginine deiminase; Provisional; Region: PRK01388 1064551013278 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1064551013279 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 1064551013280 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1064551013281 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1064551013282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 1064551013283 RNase E inhibitor protein; Provisional; Region: PRK11191 1064551013284 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 1064551013285 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1064551013286 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064551013287 Coenzyme A binding pocket [chemical binding]; other site 1064551013288 Predicted membrane protein [Function unknown]; Region: COG4269 1064551013289 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1064551013290 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1064551013291 HIGH motif; other site 1064551013292 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1064551013293 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1064551013294 active site 1064551013295 KMSKS motif; other site 1064551013296 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1064551013297 tRNA binding surface [nucleotide binding]; other site 1064551013298 anticodon binding site; other site 1064551013299 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1064551013300 DNA polymerase III subunit chi; Validated; Region: PRK05728 1064551013301 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1064551013302 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1064551013303 interface (dimer of trimers) [polypeptide binding]; other site 1064551013304 Substrate-binding/catalytic site; other site 1064551013305 Zn-binding sites [ion binding]; other site 1064551013306 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 1064551013307 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1064551013308 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 1064551013309 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1064551013310 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 1064551013311 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1064551013312 DNA binding site [nucleotide binding] 1064551013313 domain linker motif; other site 1064551013314 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1064551013315 putative dimerization interface [polypeptide binding]; other site 1064551013316 putative ligand binding site [chemical binding]; other site 1064551013317 gluconate transporter; Region: gntP; TIGR00791 1064551013318 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1064551013319 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 1064551013320 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1064551013321 NADP binding site [chemical binding]; other site 1064551013322 homodimer interface [polypeptide binding]; other site 1064551013323 active site 1064551013324 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 1064551013325 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 1064551013326 putative NAD(P) binding site [chemical binding]; other site 1064551013327 catalytic Zn binding site [ion binding]; other site 1064551013328 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1064551013329 ATP-binding site [chemical binding]; other site 1064551013330 Gluconate-6-phosphate binding site [chemical binding]; other site 1064551013331 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1064551013332 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1064551013333 putative NAD(P) binding site [chemical binding]; other site 1064551013334 putative substrate binding site [chemical binding]; other site 1064551013335 catalytic Zn binding site [ion binding]; other site 1064551013336 structural Zn binding site [ion binding]; other site 1064551013337 dimer interface [polypeptide binding]; other site 1064551013338 integrase; Provisional; Region: PRK09692 1064551013339 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1064551013340 active site 1064551013341 Int/Topo IB signature motif; other site 1064551013342 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1064551013343 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1064551013344 active site 1064551013345 catalytic residues [active] 1064551013346 Int/Topo IB signature motif; other site 1064551013347 DNA binding site [nucleotide binding] 1064551013348 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1064551013349 active site 1064551013350 catalytic residues [active] 1064551013351 DNA binding site [nucleotide binding] 1064551013352 Int/Topo IB signature motif; other site 1064551013353 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688 1064551013354 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1064551013355 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 1064551013356 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1064551013357 DNA methylase; Region: N6_N4_Mtase; pfam01555 1064551013358 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 1064551013359 HNH endonuclease; Region: HNH_2; pfam13391 1064551013360 hypothetical protein; Provisional; Region: PRK12378 1064551013361 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1064551013362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064551013363 S-adenosylmethionine binding site [chemical binding]; other site 1064551013364 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1064551013365 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064551013366 S-adenosylmethionine binding site [chemical binding]; other site 1064551013367 hypothetical protein; Provisional; Region: PRK13687 1064551013368 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 1064551013369 Uncharacterized conserved protein [Function unknown]; Region: COG3439 1064551013370 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1064551013371 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 1064551013372 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1064551013373 DNA-binding site [nucleotide binding]; DNA binding site 1064551013374 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1064551013375 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1064551013376 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1064551013377 active site 1064551013378 HIGH motif; other site 1064551013379 dimer interface [polypeptide binding]; other site 1064551013380 KMSKS motif; other site 1064551013381 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 1064551013382 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1064551013383 aspartate racemase; Region: asp_race; TIGR00035 1064551013384 cell density-dependent motility repressor; Provisional; Region: PRK10082 1064551013385 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1064551013386 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1064551013387 dimerization interface [polypeptide binding]; other site 1064551013388 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 1064551013389 isoaspartyl dipeptidase; Provisional; Region: PRK10657 1064551013390 dimer interface [polypeptide binding]; other site 1064551013391 active site 1064551013392 hypothetical protein; Provisional; Region: PRK10519 1064551013393 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1064551013394 Nucleoside recognition; Region: Gate; pfam07670 1064551013395 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 1064551013396 Predicted membrane protein [Function unknown]; Region: COG2733 1064551013397 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 1064551013398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1064551013399 putative substrate translocation pore; other site 1064551013400 putative transposase; Provisional; Region: PRK09857 1064551013401 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1064551013402 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1064551013403 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1064551013404 NAD(P) binding site [chemical binding]; other site 1064551013405 catalytic residues [active] 1064551013406 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 1064551013407 Protein of unknown function DUF91; Region: DUF91; cl00709 1064551013408 Uncharacterized conserved protein [Function unknown]; Region: COG3586 1064551013409 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1064551013410 Protein of unknown function DUF262; Region: DUF262; pfam03235 1064551013411 Uncharacterized conserved protein [Function unknown]; Region: COG3472 1064551013412 endoribonuclease SymE; Provisional; Region: PRK13605 1064551013413 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1064551013414 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1064551013415 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1064551013416 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1064551013417 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1064551013418 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 1064551013419 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1064551013420 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1064551013421 ATP binding site [chemical binding]; other site 1064551013422 putative Mg++ binding site [ion binding]; other site 1064551013423 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 1064551013424 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1064551013425 P-loop, Walker A motif; other site 1064551013426 Base recognition motif; other site 1064551013427 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1064551013428 Uncharacterized small protein [Function unknown]; Region: COG2879 1064551013429 carbon starvation protein A; Provisional; Region: PRK15015 1064551013430 Carbon starvation protein CstA; Region: CstA; pfam02554 1064551013431 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1064551013432 methyl-accepting protein IV; Provisional; Region: PRK09793 1064551013433 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1064551013434 dimer interface [polypeptide binding]; other site 1064551013435 ligand binding site [chemical binding]; other site 1064551013436 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1064551013437 dimerization interface [polypeptide binding]; other site 1064551013438 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1064551013439 dimer interface [polypeptide binding]; other site 1064551013440 putative CheW interface [polypeptide binding]; other site 1064551013441 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1064551013442 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064551013443 Walker A motif; other site 1064551013444 ATP binding site [chemical binding]; other site 1064551013445 Walker B motif; other site 1064551013446 arginine finger; other site 1064551013447 Transcriptional antiterminator [Transcription]; Region: COG3933 1064551013448 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1064551013449 active pocket/dimerization site; other site 1064551013450 active site 1064551013451 phosphorylation site [posttranslational modification] 1064551013452 PRD domain; Region: PRD; pfam00874 1064551013453 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1064551013454 active pocket/dimerization site; other site 1064551013455 active site 1064551013456 phosphorylation site [posttranslational modification] 1064551013457 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1064551013458 active site 1064551013459 phosphorylation site [posttranslational modification] 1064551013460 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 1064551013461 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1064551013462 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1064551013463 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1064551013464 dimer interface [polypeptide binding]; other site 1064551013465 active site 1064551013466 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1064551013467 dimer interface [polypeptide binding]; other site 1064551013468 active site 1064551013469 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1064551013470 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1064551013471 putative active site [active] 1064551013472 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1064551013473 phosphoglycerol transferase I; Provisional; Region: PRK03776 1064551013474 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1064551013475 hypothetical protein; Provisional; Region: PRK11667 1064551013476 DNA replication protein DnaC; Validated; Region: PRK07952 1064551013477 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1064551013478 Walker A motif; other site 1064551013479 ATP binding site [chemical binding]; other site 1064551013480 Walker B motif; other site 1064551013481 primosomal protein DnaI; Provisional; Region: PRK02854 1064551013482 hypothetical protein; Provisional; Region: PRK09917 1064551013483 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1064551013484 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1064551013485 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1064551013486 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064551013487 DNA binding residues [nucleotide binding] 1064551013488 dimerization interface [polypeptide binding]; other site 1064551013489 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 1064551013490 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1064551013491 DNA binding residues [nucleotide binding] 1064551013492 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1064551013493 putative deacylase active site [active] 1064551013494 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 1064551013495 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1064551013496 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1064551013497 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1064551013498 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1064551013499 metal binding site [ion binding]; metal-binding site 1064551013500 active site 1064551013501 I-site; other site 1064551013502 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 1064551013503 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 1064551013504 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 1064551013505 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1064551013506 S-adenosylmethionine binding site [chemical binding]; other site 1064551013507 DNA polymerase III subunit psi; Validated; Region: PRK06856 1064551013508 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 1064551013509 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1064551013510 Coenzyme A binding pocket [chemical binding]; other site 1064551013511 dUMP phosphatase; Provisional; Region: PRK09449 1064551013512 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064551013513 motif II; other site 1064551013514 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1064551013515 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1064551013516 G1 box; other site 1064551013517 putative GEF interaction site [polypeptide binding]; other site 1064551013518 GTP/Mg2+ binding site [chemical binding]; other site 1064551013519 Switch I region; other site 1064551013520 G2 box; other site 1064551013521 G3 box; other site 1064551013522 Switch II region; other site 1064551013523 G4 box; other site 1064551013524 G5 box; other site 1064551013525 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1064551013526 periplasmic protein; Provisional; Region: PRK10568 1064551013527 BON domain; Region: BON; pfam04972 1064551013528 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1064551013529 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1064551013530 active site 1064551013531 nucleophile elbow; other site 1064551013532 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1064551013533 active site 1064551013534 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 1064551013535 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1064551013536 FeS/SAM binding site; other site 1064551013537 hypothetical protein; Provisional; Region: PRK10977 1064551013538 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1064551013539 intersubunit interface [polypeptide binding]; other site 1064551013540 active site 1064551013541 catalytic residue [active] 1064551013542 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1064551013543 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1064551013544 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1064551013545 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1064551013546 phosphopentomutase; Provisional; Region: PRK05362 1064551013547 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1064551013548 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1064551013549 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1064551013550 hypothetical protein; Provisional; Region: PRK15301 1064551013551 putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304 1064551013552 PapC N-terminal domain; Region: PapC_N; pfam13954 1064551013553 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1064551013554 PapC C-terminal domain; Region: PapC_C; pfam13953 1064551013555 putative fimbrial chaperone protein; Provisional; Region: PRK09918 1064551013556 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1064551013557 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1064551013558 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1064551013559 hypothetical protein; Provisional; Region: PRK15303 1064551013560 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 1064551013561 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1064551013562 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1064551013563 hypothetical protein; Provisional; Region: PRK11246 1064551013564 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 1064551013565 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1064551013566 motif II; other site 1064551013567 DNA repair protein RadA; Region: sms; TIGR00416 1064551013568 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1064551013569 Walker A motif/ATP binding site; other site 1064551013570 ATP binding site [chemical binding]; other site 1064551013571 Walker B motif; other site 1064551013572 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1064551013573 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1064551013574 non-specific DNA binding site [nucleotide binding]; other site 1064551013575 salt bridge; other site 1064551013576 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 1064551013577 sequence-specific DNA binding site [nucleotide binding]; other site 1064551013578 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 1064551013579 active site 1064551013580 (T/H)XGH motif; other site 1064551013581 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1064551013582 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1064551013583 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1064551013584 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1064551013585 ABC transporter; Region: ABC_tran_2; pfam12848 1064551013586 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1064551013587 lytic murein transglycosylase; Provisional; Region: PRK11619 1064551013588 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1064551013589 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1064551013590 catalytic residue [active] 1064551013591 Trp operon repressor; Provisional; Region: PRK01381 1064551013592 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 1064551013593 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1064551013594 catalytic core [active] 1064551013595 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 1064551013596 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1064551013597 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1064551013598 hypothetical protein; Provisional; Region: PRK10756 1064551013599 CreA protein; Region: CreA; pfam05981 1064551013600 DNA-binding response regulator CreB; Provisional; Region: PRK11083 1064551013601 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064551013602 active site 1064551013603 phosphorylation site [posttranslational modification] 1064551013604 intermolecular recognition site; other site 1064551013605 dimerization interface [polypeptide binding]; other site 1064551013606 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1064551013607 DNA binding site [nucleotide binding] 1064551013608 sensory histidine kinase CreC; Provisional; Region: PRK11100 1064551013609 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1064551013610 dimerization interface [polypeptide binding]; other site 1064551013611 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1064551013612 dimer interface [polypeptide binding]; other site 1064551013613 phosphorylation site [posttranslational modification] 1064551013614 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1064551013615 ATP binding site [chemical binding]; other site 1064551013616 Mg2+ binding site [ion binding]; other site 1064551013617 G-X-G motif; other site 1064551013618 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 1064551013619 putative major fimbrial protein SthE; Provisional; Region: PRK15292 1064551013620 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1064551013621 putative fimbrial protein SthD; Provisional; Region: PRK15293 1064551013622 putative fimbrial outer membrane usher protein SthC; Provisional; Region: PRK15294 1064551013623 PapC N-terminal domain; Region: PapC_N; pfam13954 1064551013624 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1064551013625 PapC C-terminal domain; Region: PapC_C; pfam13953 1064551013626 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 1064551013627 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1064551013628 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1064551013629 putative fimbrial protein SthA; Provisional; Region: PRK15296 1064551013630 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 1064551013631 Helix-turn-helix domain; Region: HTH_36; pfam13730 1064551013632 two-component response regulator; Provisional; Region: PRK11173 1064551013633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1064551013634 active site 1064551013635 phosphorylation site [posttranslational modification] 1064551013636 intermolecular recognition site; other site 1064551013637 dimerization interface [polypeptide binding]; other site 1064551013638 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1064551013639 DNA binding site [nucleotide binding] 1064551013640 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1064551013641 putative RNA methyltransferase; Provisional; Region: PRK10433