-- dump date   	20140620_054637
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
220341000001	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
220341000002	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
220341000003	putative catalytic residues [active]
220341000004	putative nucleotide binding site [chemical binding]; other site
220341000005	putative aspartate binding site [chemical binding]; other site
220341000006	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
220341000007	dimer interface [polypeptide binding]; other site
220341000008	putative threonine allosteric regulatory site; other site
220341000009	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
220341000010	putative threonine allosteric regulatory site; other site
220341000011	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
220341000012	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
220341000013	PS00324 Aspartokinase signature
220341000014	PS01042 Homoserine dehydrogenase signature
220341000015	homoserine kinase; Provisional; Region: PRK01212
220341000016	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
220341000017	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
220341000018	PS00627 GHMP kinases putative ATP-binding domain
220341000019	threonine synthase; Validated; Region: PRK09225
220341000020	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
220341000021	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
220341000022	catalytic residue [active]
220341000023	PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site
220341000024	hypothetical protein; Validated; Region: PRK02101
220341000025	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
220341000026	PS00873 Sodium:alanine symporter family signature
220341000027	transaldolase-like protein; Provisional; Region: PTZ00411
220341000028	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
220341000029	active site
220341000030	dimer interface [polypeptide binding]; other site
220341000031	catalytic residue [active]
220341000032	PS01054 Transaldolase signature 1
220341000033	PS00958 Transaldolase active site
220341000034	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
220341000035	MPT binding site; other site
220341000036	trimer interface [polypeptide binding]; other site
220341000037	PS01078 Molybdenum cofactor biosynthesis proteins signature 1
220341000038	hypothetical protein; Provisional; Region: PRK10659
220341000039	PS01114 GPR1/FUN34/yaaH family signature
220341000040	hypothetical protein; Provisional; Region: PRK10236
220341000041	Domain of unknown function (DUF3944); Region: DUF3944; pfam13099
220341000042	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735
220341000043	Protein of unknown function (DUF2541); Region: DUF2541; pfam10807
220341000044	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
220341000045	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
220341000046	nucleotide binding site [chemical binding]; other site
220341000047	NEF interaction site [polypeptide binding]; other site
220341000048	SBD interface [polypeptide binding]; other site
220341000049	PS00297 Heat shock hsp70 proteins family signature 1
220341000050	PS00329 Heat shock hsp70 proteins family signature 2
220341000051	PS01036 Heat shock hsp70 proteins family signature 3
220341000052	chaperone protein DnaJ; Provisional; Region: PRK10767
220341000053	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
220341000054	HSP70 interaction site [polypeptide binding]; other site
220341000055	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
220341000056	substrate binding site [polypeptide binding]; other site
220341000057	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
220341000058	Zn binding sites [ion binding]; other site
220341000059	dimer interface [polypeptide binding]; other site
220341000060	PS00636 Nt-dnaJ domain signature
220341000061	PS00637 CXXCXGXG dnaJ domain signature
220341000062	Transcriptional regulator [Transcription]; Region: LysR; COG0583
220341000063	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341000064	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
220341000065	dimerization interface [polypeptide binding]; other site
220341000066	Lysozyme family protein [General function prediction only]; Region: zliS; COG3926
220341000067	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
220341000068	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
220341000069	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
220341000070	Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325
220341000071	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
220341000072	active site
220341000073	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
220341000074	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
220341000075	aromatic chitin/cellulose binding site residues [chemical binding]; other site
220341000076	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
220341000077	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832
220341000078	fimbrial protein BcfA; Provisional; Region: PRK15187
220341000079	fimbrial chaperone protein BcfB; Provisional; Region: PRK15188
220341000080	Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345
220341000081	Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753
220341000082	fimbrial protein BcfD; Provisional; Region: PRK15189
220341000083	fimbrial protein BcfE; Provisional; Region: PRK15190
220341000084	fimbrial protein BcfF; Provisional; Region: PRK15191
220341000085	fimbrial chaperone BcfG; Provisional; Region: PRK15192
220341000086	Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345
220341000087	Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753
220341000088	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
220341000089	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
220341000090	catalytic residues [active]
220341000091	DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710
220341000092	Transcriptional regulator [Transcription]; Region: LysR; COG0583
220341000093	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341000094	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
220341000095	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
220341000096	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
220341000097	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
220341000098	active site
220341000099	metal binding site [ion binding]; metal-binding site
220341000100	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
220341000101	PS00786 5'-nucleotidase signature 2
220341000102	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502
220341000103	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341000104	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
220341000105	Sulfatase; Region: Sulfatase; pfam00884
220341000106	PS00523 Sulfatases signature 1
220341000107	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
220341000108	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
220341000109	FeS/SAM binding site; other site
220341000110	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
220341000111	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
220341000112	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561
220341000113	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
220341000114	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341000115	The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429
220341000116	putative dimerization interface [polypeptide binding]; other site
220341000117	PS00044 Bacterial regulatory proteins, lysR family signature
220341000118	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
220341000119	Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055
220341000120	XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591
220341000121	putative active site [active]
220341000122	putative catalytic site [active]
220341000123	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
220341000124	putative symporter YagG; Provisional; Region: PRK09669; cl15392
220341000125	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
220341000126	Protein of unknown function (DUF2575); Region: DUF2575; pfam10837
220341000127	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
220341000128	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
220341000129	active site
220341000130	Riboflavin kinase; Region: Flavokinase; smart00904
220341000131	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
220341000132	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
220341000133	active site
220341000134	HIGH motif; other site
220341000135	KMSKS motif; other site
220341000136	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
220341000137	tRNA binding surface [nucleotide binding]; other site
220341000138	anticodon binding site; other site
220341000139	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
220341000140	PS00178 Aminoacyl-transfer RNA synthetases class-I signature
220341000141	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
220341000142	PS00855 Signal peptidases II signature
220341000143	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
220341000144	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
220341000145	PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1
220341000146	PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2
220341000147	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944
220341000148	Fe-S cluster binding site [ion binding]; other site
220341000149	substrate binding site [chemical binding]; other site
220341000150	catalytic site [active]
220341000151	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
220341000152	active site
220341000153	tetramer interface [polypeptide binding]; other site
220341000154	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
220341000155	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
220341000156	active site
220341000157	phosphorylation site [posttranslational modification]
220341000158	intermolecular recognition site; other site
220341000159	dimerization interface [polypeptide binding]; other site
220341000160	Transcriptional regulator; Region: CitT; pfam12431
220341000161	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
220341000162	Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827
220341000163	PAS domain; Region: PAS; smart00091
220341000164	Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689
220341000165	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
220341000166	ATP binding site [chemical binding]; other site
220341000167	Mg2+ binding site [ion binding]; other site
220341000168	G-X-G motif; other site
220341000169	PS00017 ATP/GTP-binding site motif A (P-loop)
220341000170	oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15477
220341000171	oxaloacetate decarboxylase; Provisional; Region: PRK14040
220341000172	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
220341000173	active site
220341000174	catalytic residues [active]
220341000175	metal binding site [ion binding]; metal-binding site
220341000176	homodimer binding site [polypeptide binding]; other site
220341000177	Conserved carboxylase domain; Region: PYC_OADA; pfam02436
220341000178	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
220341000179	carboxyltransferase (CT) interaction site; other site
220341000180	biotinylation site [posttranslational modification]; other site
220341000181	PS00188 Biotin-requiring enzymes attachment site
220341000182	PS00095 C-5 cytosine-specific DNA methylases C-terminal signature
220341000183	oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919
220341000184	Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493
220341000185	Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053
220341000186	Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169
220341000187	putative active site [active]
220341000188	(T/H)XGH motif; other site
220341000189	Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052
220341000190	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
220341000191	PS00017 ATP/GTP-binding site motif A (P-loop)
220341000192	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
220341000193	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
220341000194	PS00017 ATP/GTP-binding site motif A (P-loop)
220341000195	Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697
220341000196	triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125
220341000197	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
220341000198	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
220341000199	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
220341000200	PS01298 Dihydrodipicolinate reductase signature
220341000201	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
220341000202	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
220341000203	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
220341000204	catalytic site [active]
220341000205	subunit interface [polypeptide binding]; other site
220341000206	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
220341000207	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
220341000208	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
220341000209	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096
220341000210	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
220341000211	ATP-grasp domain; Region: ATP-grasp_4; cl17255
220341000212	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
220341000213	IMP binding site; other site
220341000214	dimer interface [polypeptide binding]; other site
220341000215	interdomain contacts; other site
220341000216	partial ornithine binding site; other site
220341000217	PS00866 Carbamoyl-phosphate synthase subdomain signature 1
220341000218	PS00867 Carbamoyl-phosphate synthase subdomain signature 2
220341000219	PS00866 Carbamoyl-phosphate synthase subdomain signature 1
220341000220	PS00867 Carbamoyl-phosphate synthase subdomain signature 2
220341000221	PS00017 ATP/GTP-binding site motif A (P-loop)
220341000222	DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476
220341000223	carnitine operon protein CaiE; Provisional; Region: PRK13627
220341000224	paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745
220341000225	putative trimer interface [polypeptide binding]; other site
220341000226	putative metal binding site [ion binding]; other site
220341000227	carnitinyl-CoA dehydratase; Provisional; Region: PRK03580
220341000228	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
220341000229	substrate binding site [chemical binding]; other site
220341000230	oxyanion hole (OAH) forming residues; other site
220341000231	trimer interface [polypeptide binding]; other site
220341000232	PS00166 Enoyl-CoA hydratase/isomerase signature
220341000233	putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008
220341000234	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934
220341000235	acyl-activating enzyme (AAE) consensus motif; other site
220341000236	putative AMP binding site [chemical binding]; other site
220341000237	putative active site [active]
220341000238	putative CoA binding site [chemical binding]; other site
220341000239	PS00455 Putative AMP-binding domain signature
220341000240	crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525
220341000241	crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354
220341000242	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
220341000243	active site
220341000244	PS00073 Acyl-CoA dehydrogenases signature 2
220341000245	PS00072 Acyl-CoA dehydrogenases signature 1
220341000246	L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356
220341000247	PS01303 BCCT family of transporters signature
220341000248	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
220341000249	Ligand binding site [chemical binding]; other site
220341000250	PS01065 Electron transfer flavoprotein beta-subunit signature
220341000251	putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363
220341000252	Electron transfer flavoprotein domain; Region: ETF; pfam01012
220341000253	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
220341000254	PS00696 Electron transfer flavoprotein alpha-subunit signature
220341000255	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
220341000256	putative oxidoreductase FixC; Provisional; Region: PRK10157
220341000257	ferredoxin-like protein FixX; Provisional; Region: PRK15449
220341000258	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341000259	benzoate transport; Region: 2A0115; TIGR00895
220341000260	putative substrate translocation pore; other site
220341000261	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
220341000262	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341000263	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
220341000264	glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871
220341000265	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
220341000266	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
220341000267	Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816
220341000268	TrkA-N domain; Region: TrkA_N; pfam02254
220341000269	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
220341000270	folate binding site [chemical binding]; other site
220341000271	NADP+ binding site [chemical binding]; other site
220341000272	PS00075 Dihydrofolate reductase signature
220341000273	bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668
220341000274	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
220341000275	active site
220341000276	metal binding site [ion binding]; metal-binding site
220341000277	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
220341000278	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
220341000279	PS01131 Ribosomal RNA adenine dimethylases signature
220341000280	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
220341000281	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
220341000282	SurA N-terminal domain; Region: SurA_N; pfam09312
220341000283	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
220341000284	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
220341000285	PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature
220341000286	PS00017 ATP/GTP-binding site motif A (P-loop)
220341000287	PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature
220341000288	LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761
220341000289	OstA-like protein; Region: OstA; pfam03968
220341000290	Organic solvent tolerance protein; Region: OstA_C; pfam04453
220341000291	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
220341000292	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
220341000293	putative metal binding site [ion binding]; other site
220341000294	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
220341000295	HSP70 interaction site [polypeptide binding]; other site
220341000296	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
220341000297	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
220341000298	active site
220341000299	PS01129 Rlu family of pseudouridine synthase signature
220341000300	ATP-dependent helicase HepA; Validated; Region: PRK04914
220341000301	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
220341000302	ATP binding site [chemical binding]; other site
220341000303	putative Mg++ binding site [ion binding]; other site
220341000304	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
220341000305	nucleotide binding region [chemical binding]; other site
220341000306	ATP-binding site [chemical binding]; other site
220341000307	RNA polymerase recycling family C-terminal; Region: RapA_C; pfam12137
220341000308	DNA polymerase II; Reviewed; Region: PRK05762
220341000309	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
220341000310	active site
220341000311	catalytic site [active]
220341000312	substrate binding site [chemical binding]; other site
220341000313	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
220341000314	active site
220341000315	metal-binding site
220341000316	PS00116 DNA polymerase family B signature
220341000317	Transposase IS200 like; Region: Y1_Tnp; pfam01797
220341000318	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
220341000319	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
220341000320	Probable transposase; Region: OrfB_IS605; pfam01385
220341000321	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
220341000322	PS00017 ATP/GTP-binding site motif A (P-loop)
220341000323	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
220341000324	intersubunit interface [polypeptide binding]; other site
220341000325	active site
220341000326	Zn2+ binding site [ion binding]; other site
220341000327	L-arabinose isomerase; Provisional; Region: PRK02929
220341000328	L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557
220341000329	putative hexamer (dimer of trimers) interface [polypeptide binding]; other site
220341000330	trimer interface [polypeptide binding]; other site
220341000331	putative substrate binding site [chemical binding]; other site
220341000332	putative metal binding site [ion binding]; other site
220341000333	ribulokinase; Provisional; Region: PRK04123
220341000334	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
220341000335	N- and C-terminal domain interface [polypeptide binding]; other site
220341000336	active site
220341000337	MgATP binding site [chemical binding]; other site
220341000338	catalytic site [active]
220341000339	metal binding site [ion binding]; metal-binding site
220341000340	carbohydrate binding site [chemical binding]; other site
220341000341	homodimer interface [polypeptide binding]; other site
220341000342	DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572
220341000343	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
220341000344	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341000345	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341000346	PS00041 Bacterial regulatory proteins, araC family signature
220341000347	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
220341000348	thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771
220341000349	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
220341000350	Walker A/P-loop; other site
220341000351	ATP binding site [chemical binding]; other site
220341000352	Q-loop/lid; other site
220341000353	ABC transporter signature motif; other site
220341000354	Walker B; other site
220341000355	D-loop; other site
220341000356	H-loop/switch region; other site
220341000357	PS00211 ABC transporters family signature
220341000358	PS00017 ATP/GTP-binding site motif A (P-loop)
220341000359	thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433
220341000360	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341000361	dimer interface [polypeptide binding]; other site
220341000362	conserved gate region; other site
220341000363	putative PBP binding loops; other site
220341000364	ABC-ATPase subunit interface; other site
220341000365	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341000366	dimer interface [polypeptide binding]; other site
220341000367	conserved gate region; other site
220341000368	putative PBP binding loops; other site
220341000369	ABC-ATPase subunit interface; other site
220341000370	thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205
220341000371	PS01037 Bacterial extracellular solute-binding proteins
220341000372	transcriptional regulator SgrR; Provisional; Region: PRK13626
220341000373	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
220341000374	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
220341000375	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
220341000376	substrate binding site [chemical binding]; other site
220341000377	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
220341000378	substrate binding site [chemical binding]; other site
220341000379	ligand binding site [chemical binding]; other site
220341000380	PS01244 Aconitase family signature 2
220341000381	PS00450 Aconitase family signature 1
220341000382	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
220341000383	PS00470 Isocitrate and isopropylmalate dehydrogenases signature
220341000384	2-isopropylmalate synthase; Validated; Region: PRK00915
220341000385	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
220341000386	active site
220341000387	catalytic residues [active]
220341000388	metal binding site [ion binding]; metal-binding site
220341000389	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
220341000390	PS00816 Alpha-isopropylmalate and homocitrate synthases signature 2
220341000391	PS00815 Alpha-isopropylmalate and homocitrate synthases signature 1
220341000392	leu operon leader peptide; Provisional; Region: PRK14744
220341000393	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
220341000394	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341000395	The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466
220341000396	putative substrate binding pocket [chemical binding]; other site
220341000397	putative dimerization interface [polypeptide binding]; other site
220341000398	PS00044 Bacterial regulatory proteins, lysR family signature
220341000399	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979
220341000400	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
220341000401	PYR/PP interface [polypeptide binding]; other site
220341000402	dimer interface [polypeptide binding]; other site
220341000403	TPP binding site [chemical binding]; other site
220341000404	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
220341000405	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
220341000406	TPP-binding site [chemical binding]; other site
220341000407	dimer interface [polypeptide binding]; other site
220341000408	PS00187 Thiamine pyrophosphate enzymes signature
220341000409	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
220341000410	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
220341000411	putative valine binding site [chemical binding]; other site
220341000412	dimer interface [polypeptide binding]; other site
220341000413	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
220341000414	DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303
220341000415	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
220341000416	DNA binding site [nucleotide binding]
220341000417	domain linker motif; other site
220341000418	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
220341000419	dimerization interface [polypeptide binding]; other site
220341000420	ligand binding site [chemical binding]; other site
220341000421	PS00356 Bacterial regulatory proteins, lacI family signature
220341000422	mraZ protein; Region: TIGR00242
220341000423	MraZ protein; Region: MraZ; pfam02381
220341000424	MraZ protein; Region: MraZ; pfam02381
220341000425	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
220341000426	cell division protein FtsL; Provisional; Region: PRK10772
220341000427	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
220341000428	Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717
220341000429	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
220341000430	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
220341000431	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
220341000432	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
220341000433	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
220341000434	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773
220341000435	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
220341000436	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
220341000437	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
220341000438	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
220341000439	Mg++ binding site [ion binding]; other site
220341000440	putative catalytic motif [active]
220341000441	putative substrate binding site [chemical binding]; other site
220341000442	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806
220341000443	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
220341000444	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
220341000445	PS00012 Phosphopantetheine attachment site
220341000446	cell division protein FtsW; Provisional; Region: PRK10774
220341000447	PS00428 Cell cycle proteins ftsW / rodA / spoVE signature
220341000448	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
220341000449	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
220341000450	active site
220341000451	homodimer interface [polypeptide binding]; other site
220341000452	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
220341000453	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
220341000454	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
220341000455	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
220341000456	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
220341000457	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
220341000458	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
220341000459	PS00843 D-alanine--D-alanine ligase signature 1
220341000460	PS00844 D-alanine--D-alanine ligase signature 2
220341000461	cell division protein FtsQ; Provisional; Region: PRK10775
220341000462	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
220341000463	Cell division protein FtsQ; Region: FtsQ; pfam03799
220341000464	cell division protein FtsA; Reviewed; Region: ftsA; PRK09472
220341000465	Cell division protein FtsA; Region: FtsA; pfam14450
220341000466	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
220341000467	Cell division protein FtsA; Region: FtsA; pfam14450
220341000468	cell division protein FtsZ; Validated; Region: PRK09330
220341000469	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
220341000470	nucleotide binding site [chemical binding]; other site
220341000471	SulA interaction site; other site
220341000472	cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483
220341000473	PS01134 FtsZ protein signature 1
220341000474	PS01135 FtsZ protein signature 2
220341000475	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
220341000476	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
220341000477	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
220341000478	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
220341000479	SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516
220341000480	SEC-C motif; Region: SEC-C; pfam02810
220341000481	PS01312 Protein secA signatures
220341000482	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
220341000483	active site
220341000484	8-oxo-dGMP binding site [chemical binding]; other site
220341000485	nudix motif; other site
220341000486	metal binding site [ion binding]; metal-binding site
220341000487	PS00893 mutT domain signature
220341000488	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
220341000489	active site
220341000490	catalytic tetrad [active]
220341000491	Transcriptional regulator [Transcription]; Region: LysR; COG0583
220341000492	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341000493	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
220341000494	putative effector binding pocket; other site
220341000495	putative dimerization interface [polypeptide binding]; other site
220341000496	PS00044 Bacterial regulatory proteins, lysR family signature
220341000497	DNA gyrase inhibitor; Reviewed; Region: PRK00418
220341000498	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582
220341000499	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
220341000500	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
220341000501	CoA-binding site [chemical binding]; other site
220341000502	ATP-binding [chemical binding]; other site
220341000503	PS01294 Uncharacterized protein family UPF0038 signature
220341000504	PS00017 ATP/GTP-binding site motif A (P-loop)
220341000505	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096
220341000506	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
220341000507	active site
220341000508	PS00487 IMP dehydrogenase / GMP reductase signature
220341000509	type IV pilin biogenesis protein; Provisional; Region: PRK10573
220341000510	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
220341000511	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
220341000512	hypothetical protein; Provisional; Region: PRK10436
220341000513	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
220341000514	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
220341000515	Walker A motif; other site
220341000516	ATP binding site [chemical binding]; other site
220341000517	Walker B motif; other site
220341000518	PS00662 Bacterial type II secretion system protein E signature
220341000519	PS00017 ATP/GTP-binding site motif A (P-loop)
220341000520	putative major pilin subunit; Provisional; Region: PRK10574
220341000521	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
220341000522	Pilin (bacterial filament); Region: Pilin; pfam00114
220341000523	PS00409 Prokaryotic N-terminal methylation site
220341000524	quinolinate phosphoribosyltransferase; Validated; Region: PRK09016
220341000525	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
220341000526	dimerization interface [polypeptide binding]; other site
220341000527	active site
220341000528	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
220341000529	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
220341000530	amidase catalytic site [active]
220341000531	Zn binding residues [ion binding]; other site
220341000532	substrate binding site [chemical binding]; other site
220341000533	regulatory protein AmpE; Provisional; Region: PRK10987
220341000534	Glycosyl hydrolase family 43; Region: GH43_1; cd08980
220341000535	active site
220341000536	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
220341000537	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341000538	putative substrate translocation pore; other site
220341000539	aromatic amino acid transporter; Provisional; Region: PRK10238
220341000540	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
220341000541	PS00218 Amino acid permeases signature
220341000542	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
220341000543	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
220341000544	DNA-binding site [nucleotide binding]; DNA binding site
220341000545	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
220341000546	PS00043 Bacterial regulatory proteins, gntR family signature
220341000547	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
220341000548	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
220341000549	dimer interface [polypeptide binding]; other site
220341000550	TPP-binding site [chemical binding]; other site
220341000551	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
220341000552	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
220341000553	E3 interaction surface; other site
220341000554	lipoyl attachment site [posttranslational modification]; other site
220341000555	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
220341000556	E3 interaction surface; other site
220341000557	lipoyl attachment site [posttranslational modification]; other site
220341000558	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
220341000559	E3 interaction surface; other site
220341000560	lipoyl attachment site [posttranslational modification]; other site
220341000561	e3 binding domain; Region: E3_binding; pfam02817
220341000562	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
220341000563	PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site
220341000564	PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site
220341000565	PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site
220341000566	PS00017 ATP/GTP-binding site motif A (P-loop)
220341000567	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
220341000568	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
220341000569	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
220341000570	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
220341000571	PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site
220341000572	Protein of unknown function (DUF2950); Region: DUF2950; pfam11453
220341000573	Protein of unknown function (DUF3300); Region: DUF3300; pfam11737
220341000574	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
220341000575	Aconitate B N-terminal domain; Region: Aconitase_B_N; pfam11791
220341000576	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
220341000577	substrate binding site [chemical binding]; other site
220341000578	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
220341000579	substrate binding site [chemical binding]; other site
220341000580	ligand binding site [chemical binding]; other site
220341000581	PS00450 Aconitase family signature 1
220341000582	PS01244 Aconitase family signature 2
220341000583	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3112
220341000584	2-keto-3-deoxygluconate permease; Provisional; Region: PRK12460
220341000585	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
220341000586	4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371
220341000587	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
220341000588	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
220341000589	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
220341000590	PS00894 Bacterial regulatory proteins, deoR family signature
220341000591	S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462
220341000592	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
220341000593	S-adenosylmethionine binding site [chemical binding]; other site
220341000594	PS00136 Serine proteases, subtilase family, aspartic acid active site
220341000595	PS01330 Spermidine/spermine synthases family signature
220341000596	multicopper oxidase; Provisional; Region: PRK10965
220341000597	Cupredoxin superfamily; Region: Cupredoxin; cl19115
220341000598	The second Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_2_CueO_FtsP; cd13867
220341000599	Domain 1 interface [polypeptide binding]; other site
220341000600	Domain 3 interface [polypeptide binding]; other site
220341000601	The third Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_3_CueO_FtsP; cd13890
220341000602	Domain 2 interface [polypeptide binding]; other site
220341000603	Domain 1 interface [polypeptide binding]; other site
220341000604	Type 1 (T1) Cu binding site [ion binding]; other site
220341000605	trinuclear Cu binding site [ion binding]; other site
220341000606	PS00080 Multicopper oxidases signature 2
220341000607	Glucose dehydrogenase [Carbohydrate transport and metabolism]; Region: Gcd; COG4993
220341000608	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
220341000609	Trp docking motif [polypeptide binding]; other site
220341000610	putative active site [active]
220341000611	PS00364 Bacterial quinoprotein dehydrogenases signature 2
220341000612	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
220341000613	active site
220341000614	PS00103 Purine/pyrimidine phosphoribosyl transferases signature
220341000615	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
220341000616	active site clefts [active]
220341000617	zinc binding site [ion binding]; other site
220341000618	dimer interface [polypeptide binding]; other site
220341000619	PS00705 Prokaryotic-type carbonic anhydrases signature 2
220341000620	PS00704 Prokaryotic-type carbonic anhydrases signature 1
220341000621	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
220341000622	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
220341000623	Walker A/P-loop; other site
220341000624	ATP binding site [chemical binding]; other site
220341000625	Q-loop/lid; other site
220341000626	ABC transporter signature motif; other site
220341000627	Walker B; other site
220341000628	D-loop; other site
220341000629	H-loop/switch region; other site
220341000630	PS00017 ATP/GTP-binding site motif A (P-loop)
220341000631	PS00211 ABC transporters family signature
220341000632	inner membrane transport permease; Provisional; Region: PRK15066
220341000633	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
220341000634	PS00890 ABC-2 type transport system integral membrane proteins signature
220341000635	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
220341000636	active pocket/dimerization site; other site
220341000637	active site
220341000638	phosphorylation site [posttranslational modification]
220341000639	Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966
220341000640	putative active site [active]
220341000641	putative metal binding site [ion binding]; other site
220341000642	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
220341000643	tetramerization interface [polypeptide binding]; other site
220341000644	active site
220341000645	Pantoate-beta-alanine ligase; Region: PanC; cd00560
220341000646	active site
220341000647	ATP-binding site [chemical binding]; other site
220341000648	pantoate-binding site; other site
220341000649	HXXH motif; other site
220341000650	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
220341000651	oligomerization interface [polypeptide binding]; other site
220341000652	active site
220341000653	metal binding site [ion binding]; metal-binding site
220341000654	putative fimbrial protein StaF; Provisional; Region: PRK15262
220341000655	putative fimbrial protein StaE; Provisional; Region: PRK15263
220341000656	putative fimbrial protein StaD; Provisional; Region: PRK15241
220341000657	putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828
220341000658	PapC N-terminal domain; Region: PapC_N; pfam13954
220341000659	Outer membrane usher protein; Region: Usher; pfam00577
220341000660	PapC C-terminal domain; Region: PapC_C; pfam13953
220341000661	PS01151 Fimbrial biogenesis outer membrane usher protein signature
220341000662	putative chaperone protein EcpD; Provisional; Region: PRK09926
220341000663	Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345
220341000664	Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753
220341000665	PS00635 Gram-negative pili assembly chaperone signature
220341000666	putative fimbrial protein StaA; Provisional; Region: PRK15239
220341000667	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
220341000668	catalytic center binding site [active]
220341000669	ATP binding site [chemical binding]; other site
220341000670	PS00794 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature
220341000671	poly(A) polymerase I; Provisional; Region: pcnB; PRK11623
220341000672	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
220341000673	active site
220341000674	NTP binding site [chemical binding]; other site
220341000675	metal binding triad [ion binding]; metal-binding site
220341000676	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
220341000677	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
220341000678	Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008
220341000679	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
220341000680	active site
220341000681	nucleotide binding site [chemical binding]; other site
220341000682	HIGH motif; other site
220341000683	KMSKS motif; other site
220341000684	RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778
220341000685	PS01102 Prokaryotic dksA/traR C4-type zinc finger
220341000686	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
220341000687	2'-5' RNA ligase; Provisional; Region: PRK15124
220341000688	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
220341000689	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
220341000690	ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664
220341000691	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
220341000692	ATP binding site [chemical binding]; other site
220341000693	putative Mg++ binding site [ion binding]; other site
220341000694	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
220341000695	nucleotide binding region [chemical binding]; other site
220341000696	ATP-binding site [chemical binding]; other site
220341000697	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
220341000698	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
220341000699	PS00017 ATP/GTP-binding site motif A (P-loop)
220341000700	PS00177 DNA topoisomerase II signature
220341000701	bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506
220341000702	Transmembrane domain of transglycosylase PBP1 at N-terminal; Region: PBP1_TM; pfam14812
220341000703	Bifunctional transglycosylase second domain; Region: UB2H; pfam14814
220341000704	Transglycosylase; Region: Transgly; pfam00912
220341000705	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
220341000706	PS00017 ATP/GTP-binding site motif A (P-loop)
220341000707	PS01156 TonB-dependent receptor proteins signature 2
220341000708	iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575
220341000709	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
220341000710	Walker A/P-loop; other site
220341000711	ATP binding site [chemical binding]; other site
220341000712	Q-loop/lid; other site
220341000713	ABC transporter signature motif; other site
220341000714	Walker B; other site
220341000715	D-loop; other site
220341000716	H-loop/switch region; other site
220341000717	PS00017 ATP/GTP-binding site motif A (P-loop)
220341000718	PS00211 ABC transporters family signature
220341000719	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
220341000720	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
220341000721	siderophore binding site; other site
220341000722	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2
220341000723	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
220341000724	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
220341000725	ABC-ATPase subunit  interface; other site
220341000726	dimer interface [polypeptide binding]; other site
220341000727	putative PBP binding regions; other site
220341000728	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
220341000729	ABC-ATPase subunit  interface; other site
220341000730	dimer interface [polypeptide binding]; other site
220341000731	putative PBP binding regions; other site
220341000732	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
220341000733	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
220341000734	inhibitor-cofactor binding pocket; inhibition site
220341000735	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341000736	catalytic residue [active]
220341000737	PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site
220341000738	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
220341000739	Cl- selectivity filter; other site
220341000740	Cl- binding residues [ion binding]; other site
220341000741	pore gating glutamate residue; other site
220341000742	dimer interface [polypeptide binding]; other site
220341000743	H+/Cl- coupling transport residue; other site
220341000744	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
220341000745	PS01152 Hypothetical hesB/yadR/yfhF family signature
220341000746	hypothetical protein; Provisional; Region: PRK10578
220341000747	UPF0126 domain; Region: UPF0126; pfam03458
220341000748	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
220341000749	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
220341000750	cobalamin binding residues [chemical binding]; other site
220341000751	putative BtuC binding residues; other site
220341000752	dimer interface [polypeptide binding]; other site
220341000753	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
220341000754	deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926
220341000755	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
220341000756	Zn2+ binding site [ion binding]; other site
220341000757	Mg2+ binding site [ion binding]; other site
220341000758	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
220341000759	serine endoprotease; Provisional; Region: PRK10942
220341000760	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
220341000761	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
220341000762	protein binding site [polypeptide binding]; other site
220341000763	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
220341000764	carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477
220341000765	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
220341000766	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
220341000767	hypothetical protein; Provisional; Region: PRK13677
220341000768	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
220341000769	Tetrahydrodipicolinate N-succinyltransferase N-terminal; Region: THDPS_N_2; pfam14805
220341000770	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
220341000771	trimer interface [polypeptide binding]; other site
220341000772	active site
220341000773	substrate binding site [chemical binding]; other site
220341000774	CoA binding site [chemical binding]; other site
220341000775	PS00101 Hexapeptide-repeat containing-transferases signature
220341000776	PII uridylyl-transferase; Provisional; Region: PRK05007
220341000777	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
220341000778	metal binding triad; other site
220341000779	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
220341000780	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
220341000781	Zn2+ binding site [ion binding]; other site
220341000782	Mg2+ binding site [ion binding]; other site
220341000783	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
220341000784	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
220341000785	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
220341000786	active site
220341000787	PS00680 Methionine aminopeptidase subfamily 1 signature
220341000788	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
220341000789	rRNA interaction site [nucleotide binding]; other site
220341000790	S8 interaction site; other site
220341000791	putative laminin-1 binding site; other site
220341000792	PS00962 Ribosomal protein S2 signature 1
220341000793	PS00963 Ribosomal protein S2 signature 2
220341000794	elongation factor Ts; Provisional; Region: tsf; PRK09377
220341000795	UBA/TS-N domain; Region: UBA; pfam00627
220341000796	PS01126 Elongation factor Ts signature 1
220341000797	PS01127 Elongation factor Ts signature 2
220341000798	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
220341000799	putative nucleotide binding site [chemical binding]; other site
220341000800	uridine monophosphate binding site [chemical binding]; other site
220341000801	homohexameric interface [polypeptide binding]; other site
220341000802	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
220341000803	hinge region; other site
220341000804	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
220341000805	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
220341000806	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
220341000807	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
220341000808	PS00017 ATP/GTP-binding site motif A (P-loop)
220341000809	Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475
220341000810	active site
220341000811	dimer interface [polypeptide binding]; other site
220341000812	PS01066 Undecaprenyl pyrophosphate synthetase family signature
220341000813	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
220341000814	PS01315 Phosphatidate cytidylyltransferase signature
220341000815	zinc metallopeptidase RseP; Provisional; Region: PRK10779
220341000816	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
220341000817	active site
220341000818	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
220341000819	protein binding site [polypeptide binding]; other site
220341000820	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
220341000821	protein binding site [polypeptide binding]; other site
220341000822	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
220341000823	putative substrate binding region [chemical binding]; other site
220341000824	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature
220341000825	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
220341000826	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
220341000827	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
220341000828	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
220341000829	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
220341000830	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
220341000831	Surface antigen; Region: Bac_surface_Ag; pfam01103
220341000832	periplasmic chaperone; Provisional; Region: PRK10780
220341000833	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
220341000834	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
220341000835	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
220341000836	trimer interface [polypeptide binding]; other site
220341000837	active site
220341000838	UDP-GlcNAc binding site [chemical binding]; other site
220341000839	lipid binding site [chemical binding]; lipid-binding site
220341000840	PS00101 Hexapeptide-repeat containing-transferases signature
220341000841	PS00101 Hexapeptide-repeat containing-transferases signature
220341000842	PS00101 Hexapeptide-repeat containing-transferases signature
220341000843	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
220341000844	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
220341000845	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
220341000846	active site
220341000847	PS00101 Hexapeptide-repeat containing-transferases signature
220341000848	PS00101 Hexapeptide-repeat containing-transferases signature
220341000849	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
220341000850	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
220341000851	Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
220341000852	RNA/DNA hybrid binding site [nucleotide binding]; other site
220341000853	active site
220341000854	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
220341000855	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
220341000856	putative active site [active]
220341000857	putative PHP Thumb interface [polypeptide binding]; other site
220341000858	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
220341000859	Helix-hairpin-helix motif; Region: HHH_6; pfam14579
220341000860	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
220341000861	generic binding surface II; other site
220341000862	generic binding surface I; other site
220341000863	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
220341000864	Transposase IS200 like; Region: Y1_Tnp; pfam01797
220341000865	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
220341000866	Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325
220341000867	putative sugar binding site [chemical binding]; other site
220341000868	catalytic residues [active]
220341000869	Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089
220341000870	PS00017 ATP/GTP-binding site motif A (P-loop)
220341000871	lysine decarboxylase LdcC; Provisional; Region: PRK15399
220341000872	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
220341000873	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
220341000874	homodimer interface [polypeptide binding]; other site
220341000875	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341000876	catalytic residue [active]
220341000877	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
220341000878	PS00703 Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
220341000879	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
220341000880	putative metal binding site [ion binding]; other site
220341000881	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
220341000882	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
220341000883	Ligand Binding Site [chemical binding]; other site
220341000884	TilS substrate binding domain; Region: TilS; pfam09179
220341000885	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
220341000886	Rho-binding antiterminator; Provisional; Region: PRK11625
220341000887	hypothetical protein; Provisional; Region: PRK04964
220341000888	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681
220341000889	hypothetical protein; Provisional; Region: PRK09256
220341000890	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
220341000891	PS00745 Prokaryotic-type class I peptide chain release factors signature
220341000892	lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523
220341000893	NlpE N-terminal domain; Region: NlpE; cl19736
220341000894	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341000895	Transposase IS200 like; Region: Y1_Tnp; pfam01797
220341000896	prolyl-tRNA synthetase; Provisional; Region: PRK09194
220341000897	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
220341000898	dimer interface [polypeptide binding]; other site
220341000899	motif 1; other site
220341000900	active site
220341000901	motif 2; other site
220341000902	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
220341000903	putative deacylase active site [active]
220341000904	motif 3; other site
220341000905	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
220341000906	anticodon binding site; other site
220341000907	PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1
220341000908	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
220341000909	homodimer interaction site [polypeptide binding]; other site
220341000910	cofactor binding site; other site
220341000911	PS01318 Uncharacterized protein family UPF0066 signature
220341000912	outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781
220341000913	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341000914	DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063
220341000915	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341000916	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341000917	dimer interface [polypeptide binding]; other site
220341000918	conserved gate region; other site
220341000919	putative PBP binding loops; other site
220341000920	ABC-ATPase subunit interface; other site
220341000921	PS00402 Binding-protein-dependent transport systems inner membrane comp sign.
220341000922	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
220341000923	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
220341000924	Walker A/P-loop; other site
220341000925	ATP binding site [chemical binding]; other site
220341000926	Q-loop/lid; other site
220341000927	ABC transporter signature motif; other site
220341000928	Walker B; other site
220341000929	D-loop; other site
220341000930	H-loop/switch region; other site
220341000931	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
220341000932	PS00211 ABC transporters family signature
220341000933	PS00017 ATP/GTP-binding site motif A (P-loop)
220341000934	D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213
220341000935	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
220341000936	active site
220341000937	motif I; other site
220341000938	motif II; other site
220341000939	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
220341000940	active site
220341000941	catalytic tetrad [active]
220341000942	PS00798 Aldo/keto reductase family signature 1
220341000943	PS00062 Aldo/keto reductase family signature 2
220341000944	Transcriptional regulator [Transcription]; Region: LysR; COG0583
220341000945	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341000946	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478
220341000947	putative effector binding pocket; other site
220341000948	dimerization interface [polypeptide binding]; other site
220341000949	PS00044 Bacterial regulatory proteins, lysR family signature
220341000950	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
220341000951	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341000952	putative substrate translocation pore; other site
220341000953	hypothetical protein; Provisional; Region: PRK05421
220341000954	putative catalytic site [active]
220341000955	putative metal binding site [ion binding]; other site
220341000956	putative phosphate binding site [ion binding]; other site
220341000957	putative catalytic site [active]
220341000958	putative phosphate binding site [ion binding]; other site
220341000959	putative metal binding site [ion binding]; other site
220341000960	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
220341000961	S-adenosylmethionine binding site [chemical binding]; other site
220341000962	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
220341000963	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
220341000964	N-acetyl-D-glucosamine binding site [chemical binding]; other site
220341000965	catalytic residue [active]
220341000966	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
220341000967	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
220341000968	PS00922 Prokaryotic transglycosylases signature
220341000969	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341000970	hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241
220341000971	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
220341000972	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
220341000973	RNA/DNA hybrid binding site [nucleotide binding]; other site
220341000974	active site
220341000975	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
220341000976	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
220341000977	active site
220341000978	catalytic site [active]
220341000979	substrate binding site [chemical binding]; other site
220341000980	Salmonella Pathogenicity Island 6 (59 kb)
220341000981	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3520
220341000982	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
220341000983	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3518
220341000984	Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455
220341000985	ImpE protein; Region: ImpE; pfam07024
220341000986	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
220341000987	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
220341000988	Walker A motif; other site
220341000989	ATP binding site [chemical binding]; other site
220341000990	Walker B motif; other site
220341000991	arginine finger; other site
220341000992	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
220341000993	Walker A motif; other site
220341000994	ATP binding site [chemical binding]; other site
220341000995	Walker B motif; other site
220341000996	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
220341000997	PS00017 ATP/GTP-binding site motif A (P-loop)
220341000998	PS00870 Chaperonins clpA/B signature 1
220341000999	PS00017 ATP/GTP-binding site motif A (P-loop)
220341001000	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3516
220341001001	Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion,    and vesicular transport]; Region: Hcp; COG3157
220341001002	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3521
220341001003	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341001004	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3522
220341001005	hypothetical protein; Provisional; Region: PRK08126
220341001006	Type VI protein secretion system component VasF [Intracellular    trafficking, secretion, and vesicular transport]; Region: COG3455
220341001007	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
220341001008	ligand binding site [chemical binding]; other site
220341001009	PS00017 ATP/GTP-binding site motif A (P-loop)
220341001010	PS00017 ATP/GTP-binding site motif A (P-loop)
220341001011	Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611
220341001012	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
220341001013	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4893
220341001014	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
220341001015	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
220341001016	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
220341001017	Uncharacterized conserved protein [Function unknown]; Region: COG5435
220341001018	PS00017 ATP/GTP-binding site motif A (P-loop)
220341001019	PAAR motif; Region: PAAR_motif; pfam05488
220341001020	RHS Repeat; Region: RHS_repeat; pfam05593
220341001021	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
220341001022	RHS Repeat; Region: RHS_repeat; pfam05593
220341001023	RHS Repeat; Region: RHS_repeat; pfam05593
220341001024	RHS Repeat; Region: RHS_repeat; pfam05593
220341001025	RHS protein; Region: RHS; pfam03527
220341001026	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
220341001027	A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412
220341001028	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
220341001029	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
220341001030	RHS Repeat; Region: RHS_repeat; pfam05593
220341001031	RHS Repeat; Region: RHS_repeat; pfam05593
220341001032	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
220341001033	RHS Repeat; Region: RHS_repeat; pfam05593
220341001034	RHS Repeat; Region: RHS_repeat; pfam05593
220341001035	RHS Repeat; Region: RHS_repeat; pfam05593
220341001036	RHS Repeat; Region: RHS_repeat; pfam05593
220341001037	RHS Repeat; Region: RHS_repeat; pfam05593
220341001038	RHS protein; Region: RHS; pfam03527
220341001039	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
220341001040	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
220341001041	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
220341001042	Integrase core domain; Region: rve_3; pfam13683
220341001043	Saf-pilin pilus formation protein SafA; Provisional; Region: PRK15221
220341001044	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341001045	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341001046	pili assembly chaperone protein SafB; Provisional; Region: PRK15224
220341001047	Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345
220341001048	Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753
220341001049	PS00635 Gram-negative pili assembly chaperone signature
220341001050	pilin outer membrane usher protein SafC; Provisional; Region: PRK15223
220341001051	PapC N-terminal domain; Region: PapC_N; pfam13954
220341001052	Outer membrane usher protein; Region: Usher; pfam00577
220341001053	PapC C-terminal domain; Region: PapC_C; pfam13953
220341001054	putative pilin structural protein SafD; Provisional; Region: PRK15222
220341001055	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
220341001056	Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969
220341001057	putative active site [active]
220341001058	putative metal binding site [ion binding]; other site
220341001059	PerC transcriptional activator; Region: PerC; pfam06069
220341001061	Transcriptional regulator [Transcription]; Region: LysR; COG0583
220341001062	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341001063	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
220341001064	dimerization interface [polypeptide binding]; other site
220341001065	PS00044 Bacterial regulatory proteins, lysR family signature
220341001068	putative fimbrial protein TcfA; Provisional; Region: PRK15308
220341001069	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
220341001070	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341001071	putative fimbrial subunit TcfB; Provisional; Region: PRK15309
220341001072	fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310
220341001073	Outer membrane usher protein; Region: Usher; pfam00577
220341001074	putative fimbrial protein TcfD; Provisional; Region: PRK15311
220341001075	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
220341001076	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
220341001077	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
220341001078	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
220341001079	dimer interface [polypeptide binding]; other site
220341001080	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
220341001081	putative active site [active]
220341001082	catalytic triad [active]
220341001083	dimer interface [polypeptide binding]; other site
220341001084	multimer interface [polypeptide binding]; other site
220341001085	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
220341001086	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
220341001087	active site
220341001088	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
220341001089	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
220341001090	dimer interface [polypeptide binding]; other site
220341001091	active site
220341001092	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
220341001093	putative active site [active]
220341001094	Glutamine amidotransferases class-II; Region: GATase_2; pfam00310
220341001095	putative dimer interface [polypeptide binding]; other site
220341001096	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
220341001097	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
220341001098	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
220341001099	active site
220341001100	DNA polymerase IV; Validated; Region: PRK02406
220341001101	DNA binding site [nucleotide binding]
220341001102	release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073
220341001103	tRNA-splicing ligase RtcB; Region: RtcB; pfam01139
220341001104	peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179
220341001105	putative peptide chain release factor H; Region: release_prfH; TIGR03072
220341001106	PS00745 Prokaryotic-type class I peptide chain release factors signature
220341001107	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
220341001108	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
220341001109	metal binding site [ion binding]; metal-binding site
220341001110	dimer interface [polypeptide binding]; other site
220341001111	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
220341001112	active site
220341001113	PS00103 Purine/pyrimidine phosphoribosyl transferases signature
220341001114	Putative lysophospholipase; Region: Hydrolase_4; cl19140
220341001115	fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077
220341001116	DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984
220341001117	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
220341001118	trimer interface [polypeptide binding]; other site
220341001119	eyelet of channel; other site
220341001120	PS00576 General diffusion Gram-negative porins signature
220341001121	gamma-glutamyl kinase; Provisional; Region: PRK05429
220341001122	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
220341001123	nucleotide binding site [chemical binding]; other site
220341001124	homotetrameric interface [polypeptide binding]; other site
220341001125	putative phosphate binding site [ion binding]; other site
220341001126	putative allosteric binding site; other site
220341001127	PUA domain; Region: PUA; pfam01472
220341001128	PS00902 Glutamate 5-kinase signature
220341001129	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
220341001130	putative catalytic cysteine [active]
220341001131	PS01223 Gamma-glutamyl phosphate reductase signature
220341001132	fimbrial assembly chaperone StbE; Provisional; Region: PRK15246
220341001133	Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345
220341001134	Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753
220341001135	PS00635 Gram-negative pili assembly chaperone signature
220341001136	putative fimbrial usher protein StbD; Provisional; Region: PRK15247
220341001137	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341001138	fimbrial outer membrane usher protein StbC; Provisional; Region: PRK15248
220341001139	PapC N-terminal domain; Region: PapC_N; pfam13954
220341001140	Outer membrane usher protein; Region: Usher; pfam00577
220341001141	PapC C-terminal domain; Region: PapC_C; pfam13953
220341001142	PS01151 Fimbrial biogenesis outer membrane usher protein signature
220341001143	fimbrial chaperone protein StbB; Provisional; Region: PRK15249
220341001144	Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345
220341001145	Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753
220341001146	PS00635 Gram-negative pili assembly chaperone signature
220341001147	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
220341001148	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
220341001149	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
220341001150	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
220341001151	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
220341001152	DNA binding site [nucleotide binding]
220341001153	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
220341001154	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
220341001155	DNA binding residues [nucleotide binding]
220341001156	dimerization interface [polypeptide binding]; other site
220341001157	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
220341001158	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341001160	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
220341001161	metal-binding site [ion binding]
220341001162	putative sialic acid transporter; Region: 2A0112; TIGR00891
220341001163	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341001164	putative substrate translocation pore; other site
220341001165	PS00217 Sugar transport proteins signature 2
220341001166	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
220341001167	DNA methylase; Region: N6_N4_Mtase; cl17433
220341001168	DNA methylase; Region: N6_N4_Mtase; pfam01555
220341001169	PS00092 N-6 Adenine-specific DNA methylases signature
220341001170	PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site
220341001171	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
220341001172	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
220341001173	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
220341001174	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341001175	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
220341001176	PS00041 Bacterial regulatory proteins, araC family signature
220341001177	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
220341001178	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
220341001179	N-terminal plug; other site
220341001180	ligand-binding site [chemical binding]; other site
220341001181	The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949
220341001182	hypothetical protein; Provisional; Region: PRK09929
220341001183	propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424
220341001184	Propionate catabolism activator; Region: PrpR_N; pfam06506
220341001185	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
220341001186	Walker A motif; other site
220341001187	ATP binding site [chemical binding]; other site
220341001188	Walker B motif; other site
220341001189	arginine finger; other site
220341001190	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
220341001191	PS00688 Sigma-54 interaction domain C-terminal part signature
220341001192	PS00676 Sigma-54 interaction domain ATP-binding region B signature
220341001193	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
220341001194	tetramer interface [polypeptide binding]; other site
220341001195	active site
220341001196	Mg2+/Mn2+ binding site [ion binding]; other site
220341001197	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
220341001198	Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117
220341001199	dimer interface [polypeptide binding]; other site
220341001200	active site
220341001201	citrylCoA binding site [chemical binding]; other site
220341001202	oxalacetate/citrate binding site [chemical binding]; other site
220341001203	coenzyme A binding site [chemical binding]; other site
220341001204	catalytic triad [active]
220341001205	PS00017 ATP/GTP-binding site motif A (P-loop)
220341001206	PS00480 Citrate synthase signature
220341001207	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
220341001208	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
220341001209	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
220341001210	acyl-activating enzyme (AAE) consensus motif; other site
220341001211	AMP binding site [chemical binding]; other site
220341001212	active site
220341001213	CoA binding site [chemical binding]; other site
220341001214	PS00455 Putative AMP-binding domain signature
220341001215	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
220341001216	dimer interface [polypeptide binding]; other site
220341001217	active site
220341001218	Schiff base residues; other site
220341001219	PS00169 Delta-aminolevulinic acid dehydratase active site
220341001220	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253
220341001221	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
220341001222	Autotransporter beta-domain; Region: Autotransporter; pfam03797
220341001223	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832
220341001224	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
220341001225	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
220341001226	ligand binding site [chemical binding]; other site
220341001227	flexible hinge region; other site
220341001228	beta-lactam binding protein AmpH; Provisional; Region: PRK10662
220341001229	microcin B17 transporter; Reviewed; Region: PRK11098
220341001230	Protein of unknown function (DUF1615); Region: DUF1615; pfam07759
220341001231	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341001232	PS00017 ATP/GTP-binding site motif A (P-loop)
220341001233	Protein of unknown function (DUF2755); Region: DUF2755; pfam10954
220341001234	Protein of unknown function (DUF2754); Region: DUF2754; pfam10953
220341001235	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
220341001236	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
220341001237	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
220341001238	PS00844 D-alanine--D-alanine ligase signature 2
220341001239	PS00843 D-alanine--D-alanine ligase signature 1
220341001240	PS00017 ATP/GTP-binding site motif A (P-loop)
220341001241	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921
220341001242	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
220341001243	drug efflux system protein MdtG; Provisional; Region: PRK09874
220341001244	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341001245	putative substrate translocation pore; other site
220341001246	anti-RssB factor; Provisional; Region: PRK10244
220341001247	hypothetical protein; Provisional; Region: PRK11505
220341001248	psiF repeat; Region: PsiF_repeat; pfam07769
220341001249	psiF repeat; Region: PsiF_repeat; pfam07769
220341001250	diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245
220341001251	MASE2 domain; Region: MASE2; pfam05230
220341001252	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
220341001253	metal binding site [ion binding]; metal-binding site
220341001254	active site
220341001255	I-site; other site
220341001256	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
220341001257	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
220341001258	Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748
220341001259	PS00521 Delta 1-pyrroline-5-carboxylate reductase signature
220341001260	hypothetical protein; Validated; Region: PRK00124
220341001261	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
220341001262	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
220341001263	ADP binding site [chemical binding]; other site
220341001264	magnesium binding site [ion binding]; other site
220341001265	putative shikimate binding site; other site
220341001266	PS00017 ATP/GTP-binding site motif A (P-loop)
220341001267	PS01128 Shikimate kinase signature
220341001268	hypothetical protein; Provisional; Region: PRK10380
220341001269	hypothetical protein; Provisional; Region: PRK10481
220341001270	hypothetical protein; Provisional; Region: PRK10579
220341001271	DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974
220341001272	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
220341001273	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
220341001274	nucleotide binding site [chemical binding]; other site
220341001275	PS01125 ROK family signature
220341001276	exonuclease subunit SbcC; Provisional; Region: PRK10246
220341001277	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
220341001278	Walker A/P-loop; other site
220341001279	ATP binding site [chemical binding]; other site
220341001280	Q-loop/lid; other site
220341001281	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
220341001282	ABC transporter signature motif; other site
220341001283	Walker B; other site
220341001284	D-loop; other site
220341001285	H-loop/switch region; other site
220341001286	PS00017 ATP/GTP-binding site motif A (P-loop)
220341001287	PS00017 ATP/GTP-binding site motif A (P-loop)
220341001288	exonuclease subunit SbcD; Provisional; Region: PRK10966
220341001289	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
220341001290	active site
220341001291	metal binding site [ion binding]; metal-binding site
220341001292	DNA binding site [nucleotide binding]
220341001293	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
220341001294	transcriptional regulator PhoB; Provisional; Region: PRK10161
220341001295	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
220341001296	active site
220341001297	phosphorylation site [posttranslational modification]
220341001298	intermolecular recognition site; other site
220341001299	dimerization interface [polypeptide binding]; other site
220341001300	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
220341001301	DNA binding site [nucleotide binding]
220341001302	phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006
220341001303	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
220341001304	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
220341001305	putative active site [active]
220341001306	heme pocket [chemical binding]; other site
220341001307	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
220341001308	dimer interface [polypeptide binding]; other site
220341001309	phosphorylation site [posttranslational modification]
220341001310	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
220341001311	ATP binding site [chemical binding]; other site
220341001312	Mg2+ binding site [ion binding]; other site
220341001313	G-X-G motif; other site
220341001314	branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433
220341001315	Transposase IS200 like; Region: Y1_Tnp; pfam01797
220341001316	putative proline-specific permease; Provisional; Region: proY; PRK10580
220341001317	Spore germination protein; Region: Spore_permease; cl17796
220341001318	PS00218 Amino acid permeases signature
220341001319	maltodextrin glucosidase; Provisional; Region: PRK10785
220341001320	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
220341001321	homodimer interface [polypeptide binding]; other site
220341001322	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
220341001323	active site
220341001324	homodimer interface [polypeptide binding]; other site
220341001325	catalytic site [active]
220341001326	peroxidase; Provisional; Region: PRK15000
220341001327	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
220341001328	dimer interface [polypeptide binding]; other site
220341001329	decamer (pentamer of dimers) interface [polypeptide binding]; other site
220341001330	catalytic triad [active]
220341001331	peroxidatic and resolving cysteines [active]
220341001332	acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045
220341001333	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
220341001334	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
220341001335	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
220341001336	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
220341001337	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
220341001338	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
220341001339	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
220341001340	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
220341001341	PS00761 Signal peptidases I signature 3
220341001342	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
220341001343	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
220341001344	Protein export membrane protein; Region: SecD_SecF; pfam02355
220341001345	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
220341001346	Predicted transcriptional regulator [Transcription]; Region: COG2378
220341001347	HTH domain; Region: HTH_11; pfam08279
220341001348	WYL domain; Region: WYL; pfam13280
220341001349	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
220341001350	active site
220341001351	PS00190 Cytochrome c family heme-binding site signature
220341001352	nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106
220341001353	hypothetical protein; Provisional; Region: PRK11530
220341001354	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341001355	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
220341001356	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
220341001357	catalytic motif [active]
220341001358	Zn binding site [ion binding]; other site
220341001359	riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227
220341001360	PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature
220341001361	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
220341001362	homopentamer interface [polypeptide binding]; other site
220341001363	active site
220341001364	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
220341001365	putative RNA binding site [nucleotide binding]; other site
220341001366	thiamine monophosphate kinase; Provisional; Region: PRK05731
220341001367	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
220341001368	ATP binding site [chemical binding]; other site
220341001369	dimerization interface [polypeptide binding]; other site
220341001370	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
220341001371	tetramer interfaces [polypeptide binding]; other site
220341001372	binuclear metal-binding site [ion binding]; other site
220341001373	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
220341001374	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
220341001375	active site
220341001376	catalytic tetrad [active]
220341001377	1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204
220341001378	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
220341001379	TPP-binding site; other site
220341001380	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
220341001381	PYR/PP interface [polypeptide binding]; other site
220341001382	dimer interface [polypeptide binding]; other site
220341001383	TPP binding site [chemical binding]; other site
220341001384	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
220341001385	PS00802 Transketolase signature 2
220341001386	PS00801 Transketolase signature 1
220341001387	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
220341001388	substrate binding pocket [chemical binding]; other site
220341001389	chain length determination region; other site
220341001390	active site lid residues [active]
220341001391	substrate-Mg2+ binding site; other site
220341001392	catalytic residues [active]
220341001393	aspartate-rich region 1; other site
220341001394	aspartate-rich region 2; other site
220341001395	PS00017 ATP/GTP-binding site motif A (P-loop)
220341001396	PS00444 Polyprenyl synthetases signature 2
220341001397	PS00723 Polyprenyl synthetases signature 1
220341001398	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
220341001399	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
220341001400	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
220341001401	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
220341001402	Ligand Binding Site [chemical binding]; other site
220341001403	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
220341001404	active site residue [active]
220341001405	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
220341001406	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341001407	dimer interface [polypeptide binding]; other site
220341001408	conserved gate region; other site
220341001409	putative PBP binding loops; other site
220341001410	ABC-ATPase subunit interface; other site
220341001411	2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050
220341001412	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341001413	dimer interface [polypeptide binding]; other site
220341001414	conserved gate region; other site
220341001415	putative PBP binding loops; other site
220341001416	ABC-ATPase subunit interface; other site
220341001417	PS00402 Binding-protein-dependent transport systems inner membrane comp sign.
220341001418	2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258
220341001419	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
220341001420	Walker A/P-loop; other site
220341001421	ATP binding site [chemical binding]; other site
220341001422	Q-loop/lid; other site
220341001423	ABC transporter signature motif; other site
220341001424	Walker B; other site
220341001425	D-loop; other site
220341001426	H-loop/switch region; other site
220341001427	TOBE domain; Region: TOBE_2; pfam08402
220341001428	PS00211 ABC transporters family signature
220341001429	PS00017 ATP/GTP-binding site motif A (P-loop)
220341001430	2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046
220341001431	2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate binding protein; Region: PhnS; TIGR03227
220341001432	transcriptional regulator protein; Region: phnR; TIGR03337
220341001433	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
220341001434	DNA-binding site [nucleotide binding]; DNA binding site
220341001435	UTRA domain; Region: UTRA; pfam07702
220341001436	PS00043 Bacterial regulatory proteins, gntR family signature
220341001437	2-aminoethylphosphonate--pyruvate transaminase; Region: transamin_PhnW; TIGR02326
220341001438	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
220341001439	catalytic residue [active]
220341001440	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
220341001441	phosphonoacetaldehyde hydrolase; Region: phosphonatase; TIGR01422
220341001442	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
220341001443	motif II; other site
220341001444	oxidative-stress-resistance chaperone; Provisional; Region: PRK11574
220341001445	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
220341001446	conserved cys residue [active]
220341001447	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
220341001448	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
220341001449	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
220341001450	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
220341001451	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341001452	Major Facilitator Superfamily; Region: MFS_1; pfam07690
220341001453	putative substrate translocation pore; other site
220341001454	Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957
220341001455	putative active site [active]
220341001456	PS00943 UbiA prenyltransferase family signature
220341001457	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341001458	cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582
220341001459	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
220341001460	Subunit I/III interface [polypeptide binding]; other site
220341001461	Subunit III/IV interface [polypeptide binding]; other site
220341001462	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
220341001463	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
220341001464	D-pathway; other site
220341001465	Putative ubiquinol binding site [chemical binding]; other site
220341001466	Low-spin heme (heme b) binding site [chemical binding]; other site
220341001467	Putative water exit pathway; other site
220341001468	Binuclear center (heme o3/CuB) [ion binding]; other site
220341001469	K-pathway; other site
220341001470	Putative proton exit pathway; other site
220341001471	PS00077 Heme-copper oxidase catalytic subunit, copper B binding region signature
220341001472	cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525
220341001473	The cupredoxin domain of Ubiquinol oxidase subunit II; Region: CuRO_UO_II; cd04212
220341001474	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
220341001475	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341001476	Major Facilitator Superfamily; Region: MFS_1; pfam07690
220341001477	putative substrate translocation pore; other site
220341001478	hypothetical protein; Provisional; Region: PRK11627
220341001479	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341001480	transcriptional regulator BolA; Provisional; Region: PRK11628
220341001481	trigger factor; Provisional; Region: tig; PRK01490
220341001482	Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697
220341001483	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
220341001484	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
220341001485	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
220341001486	oligomer interface [polypeptide binding]; other site
220341001487	active site residues [active]
220341001488	PS00381 Endopeptidase Clp serine active site
220341001489	PS00382 Endopeptidase Clp histidine active site
220341001490	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
220341001491	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
220341001492	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
220341001493	Walker A motif; other site
220341001494	ATP binding site [chemical binding]; other site
220341001495	Walker B motif; other site
220341001496	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
220341001497	PS00017 ATP/GTP-binding site motif A (P-loop)
220341001498	DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787
220341001499	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
220341001500	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
220341001501	Walker A motif; other site
220341001502	ATP binding site [chemical binding]; other site
220341001503	Walker B motif; other site
220341001504	arginine finger; other site
220341001505	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
220341001506	PS00017 ATP/GTP-binding site motif A (P-loop)
220341001507	PS01046 ATP-dependent serine proteases, lon family, serine active site
220341001508	histone-like DNA-binding protein HU; Region: HU; cd13831
220341001509	dimer interface [polypeptide binding]; other site
220341001510	DNA binding site [nucleotide binding]
220341001511	PS00045 Bacterial histone-like DNA-binding proteins signature
220341001512	periplasmic folding chaperone; Provisional; Region: PRK10788
220341001513	SurA N-terminal domain; Region: SurA_N_3; cl07813
220341001514	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
220341001515	PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature
220341001516	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
220341001517	competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426
220341001518	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
220341001519	active site
220341001520	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
220341001521	Ligand Binding Site [chemical binding]; other site
220341001522	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
220341001523	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
220341001524	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
220341001525	thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126
220341001526	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
220341001527	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
220341001528	active site
220341001529	motif I; other site
220341001530	motif II; other site
220341001531	Transposase IS200 like; Region: Y1_Tnp; pfam01797
220341001532	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
220341001533	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
220341001534	catalytic residue [active]
220341001535	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
220341001536	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
220341001537	putative DNA binding site [nucleotide binding]; other site
220341001538	putative Zn2+ binding site [ion binding]; other site
220341001539	AsnC family; Region: AsnC_trans_reg; pfam01037
220341001540	PS00519 Bacterial regulatory proteins, asnC family signature
220341001541	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
220341001542	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
220341001543	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
220341001544	Walker A/P-loop; other site
220341001545	ATP binding site [chemical binding]; other site
220341001546	Q-loop/lid; other site
220341001547	ABC transporter signature motif; other site
220341001548	Walker B; other site
220341001549	D-loop; other site
220341001550	H-loop/switch region; other site
220341001551	PS00017 ATP/GTP-binding site motif A (P-loop)
220341001552	PS00211 ABC transporters family signature
220341001553	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790
220341001554	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
220341001555	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
220341001556	Walker A/P-loop; other site
220341001557	ATP binding site [chemical binding]; other site
220341001558	Q-loop/lid; other site
220341001559	ABC transporter signature motif; other site
220341001560	Walker B; other site
220341001561	D-loop; other site
220341001562	H-loop/switch region; other site
220341001563	PS00017 ATP/GTP-binding site motif A (P-loop)
220341001564	PS00211 ABC transporters family signature
220341001565	nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665
220341001566	PS00496 P-II protein urydylation site
220341001567	PS00638 P-II protein C-terminal region signature
220341001568	ammonium transporter; Provisional; Region: PRK10666
220341001569	PS01219 Ammonium transporters signature
220341001570	acyl-CoA thioesterase II; Provisional; Region: PRK10526
220341001571	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
220341001572	active site
220341001573	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
220341001574	catalytic triad [active]
220341001575	dimer interface [polypeptide binding]; other site
220341001576	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126
220341001577	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341001578	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
220341001579	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
220341001580	DNA binding site [nucleotide binding]
220341001581	active site
220341001582	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
220341001583	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
220341001584	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
220341001585	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
220341001586	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
220341001587	Inner membrane protein YlaC; Region: YlaC; pfam10777
220341001588	maltose O-acetyltransferase; Provisional; Region: PRK10092
220341001589	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
220341001590	active site
220341001591	substrate binding site [chemical binding]; other site
220341001592	trimer interface [polypeptide binding]; other site
220341001593	CoA binding site [chemical binding]; other site
220341001594	PS00101 Hexapeptide-repeat containing-transferases signature
220341001595	gene expression modulator; Provisional; Region: PRK10945
220341001596	Hha toxicity attenuator; Provisional; Region: PRK10667
220341001597	multidrug efflux system protein AcrB; Provisional; Region: PRK15127
220341001598	MMPL family; Region: MMPL; cl14618
220341001599	MMPL family; Region: MMPL; cl14618
220341001600	PS00017 ATP/GTP-binding site motif A (P-loop)
220341001601	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
220341001602	Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169
220341001603	HlyD family secretion protein; Region: HlyD_3; pfam13437
220341001604	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341001605	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
220341001606	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
220341001607	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
220341001608	PS01081 Bacterial regulatory proteins, tetR family signature
220341001609	hypothetical protein; Provisional; Region: PRK11281
220341001610	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
220341001611	Mechanosensitive ion channel; Region: MS_channel; pfam00924
220341001612	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341001613	PS01246 Uncharacterized protein family UPF0003 signature
220341001614	Uncharacterized conserved protein [Function unknown]; Region: COG5464
220341001615	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
220341001616	hypothetical protein; Provisional; Region: PRK11038
220341001617	hypothetical protein; Provisional; Region: PRK10527
220341001618	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
220341001619	active site
220341001620	PS00103 Purine/pyrimidine phosphoribosyl transferases signature
220341001621	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
220341001622	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
220341001623	Walker A motif; other site
220341001624	ATP binding site [chemical binding]; other site
220341001625	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
220341001626	Walker B motif; other site
220341001627	arginine finger; other site
220341001628	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
220341001629	DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168
220341001630	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
220341001631	PS00017 ATP/GTP-binding site motif A (P-loop)
220341001632	hypothetical protein; Validated; Region: PRK00153
220341001633	recombination protein RecR; Reviewed; Region: recR; PRK00076
220341001634	RecR protein; Region: RecR; pfam02132
220341001635	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
220341001636	putative active site [active]
220341001637	putative metal-binding site [ion binding]; other site
220341001638	tetramer interface [polypeptide binding]; other site
220341001639	PS01300 RecR protein signature
220341001640	heat shock protein 90; Provisional; Region: PRK05218
220341001641	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
220341001642	ATP binding site [chemical binding]; other site
220341001643	Mg2+ binding site [ion binding]; other site
220341001644	G-X-G motif; other site
220341001645	Hsp90 protein; Region: HSP90; pfam00183
220341001646	PS00298 Heat shock hsp90 proteins family signature
220341001647	adenylate kinase; Reviewed; Region: adk; PRK00279
220341001648	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
220341001649	AMP-binding site [chemical binding]; other site
220341001650	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
220341001651	PS00113 Adenylate kinase signature
220341001652	ferrochelatase; Reviewed; Region: hemH; PRK00035
220341001653	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
220341001654	C-terminal domain interface [polypeptide binding]; other site
220341001655	active site
220341001656	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
220341001657	active site
220341001658	N-terminal domain interface [polypeptide binding]; other site
220341001659	PS00534 Ferrochelatase signature
220341001660	acetyl esterase; Provisional; Region: PRK10162
220341001661	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
220341001662	PS01174 Lipolytic enzymes 'G-D-X-G' family, putative serine active site
220341001663	inosine/guanosine kinase; Provisional; Region: PRK15074
220341001664	substrate binding site [chemical binding]; other site
220341001665	ATP binding site [chemical binding]; other site
220341001666	PS00584 pfkB family of carbohydrate kinases signature 2
220341001667	putative cation:proton antiport protein; Provisional; Region: PRK10669
220341001668	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
220341001669	TrkA-N domain; Region: TrkA_N; pfam02254
220341001670	PS00017 ATP/GTP-binding site motif A (P-loop)
220341001671	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341001672	Major Facilitator Superfamily; Region: MFS_1; pfam07690
220341001673	putative substrate translocation pore; other site
220341001674	PS00785 5'-nucleotidase signature 1
220341001675	PS00786 5'-nucleotidase signature 2
220341001676	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
220341001677	putative deacylase active site [active]
220341001678	TraB family; Region: TraB; cl12050
220341001679	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
220341001680	copper exporting ATPase; Provisional; Region: copA; PRK10671
220341001681	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
220341001682	metal-binding site [ion binding]
220341001683	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
220341001684	metal-binding site [ion binding]
220341001685	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
220341001686	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
220341001687	motif II; other site
220341001688	PS00154 E1-E2 ATPases phosphorylation site
220341001689	PS01047 Heavy-metal-associated domain
220341001690	PS01047 Heavy-metal-associated domain
220341001691	DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227
220341001692	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
220341001693	DNA binding residues [nucleotide binding]
220341001694	dimer interface [polypeptide binding]; other site
220341001695	copper binding site [ion binding]; other site
220341001696	PS00552 Bacterial regulatory proteins, merR family signature
220341001697	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
220341001698	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
220341001699	Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829
220341001700	putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247
220341001701	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
220341001702	Walker A/P-loop; other site
220341001703	ATP binding site [chemical binding]; other site
220341001704	Q-loop/lid; other site
220341001705	ABC transporter signature motif; other site
220341001706	Walker B; other site
220341001707	D-loop; other site
220341001708	H-loop/switch region; other site
220341001709	PS00017 ATP/GTP-binding site motif A (P-loop)
220341001710	PS00211 ABC transporters family signature
220341001711	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
220341001712	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
220341001713	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
220341001714	Tetratricopeptide repeat; Region: TPR_20; pfam14561
220341001715	short chain dehydrogenase; Validated; Region: PRK06182
220341001716	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
220341001717	NADP binding site [chemical binding]; other site
220341001718	active site
220341001719	steroid binding site; other site
220341001720	PS00061 Short-chain dehydrogenases/reductases family signature
220341001721	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
220341001722	active site
220341001723	catalytic triad [active]
220341001724	oxyanion hole [active]
220341001725	switch loop; other site
220341001726	PS01098 Lipolytic enzymes 'G-D-S-L' family, serine active site
220341001727	putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584
220341001728	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
220341001729	Walker A/P-loop; other site
220341001730	ATP binding site [chemical binding]; other site
220341001731	Q-loop/lid; other site
220341001732	ABC transporter signature motif; other site
220341001733	Walker B; other site
220341001734	D-loop; other site
220341001735	H-loop/switch region; other site
220341001736	PS00017 ATP/GTP-binding site motif A (P-loop)
220341001737	PS00211 ABC transporters family signature
220341001738	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
220341001739	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
220341001740	FtsX-like permease family; Region: FtsX; pfam02687
220341001741	FtsX-like permease family; Region: FtsX; pfam02687
220341001742	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341001743	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
220341001744	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
220341001745	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
220341001746	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
220341001747	Walker A/P-loop; other site
220341001748	ATP binding site [chemical binding]; other site
220341001749	Q-loop/lid; other site
220341001750	ABC transporter signature motif; other site
220341001751	Walker B; other site
220341001752	D-loop; other site
220341001753	H-loop/switch region; other site
220341001754	NIL domain; Region: NIL; pfam09383
220341001755	PS00017 ATP/GTP-binding site motif A (P-loop)
220341001756	PS00211 ABC transporters family signature
220341001757	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341001758	dimer interface [polypeptide binding]; other site
220341001759	conserved gate region; other site
220341001760	putative PBP binding loops; other site
220341001761	ABC-ATPase subunit interface; other site
220341001762	PS00402 Binding-protein-dependent transport systems inner membrane comp sign.
220341001763	Predicted ATPase [General function prediction only]; Region: COG2603
220341001764	Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520
220341001765	active site residue [active]
220341001766	PS00017 ATP/GTP-binding site motif A (P-loop)
220341001767	DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094
220341001768	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341001769	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
220341001770	dimerization interface [polypeptide binding]; other site
220341001771	DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163
220341001772	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
220341001773	Bacterial transcriptional regulator; Region: IclR; pfam01614
220341001774	PS01051 Bacterial regulatory proteins, iclR family signature
220341001775	glyoxylate carboligase; Provisional; Region: PRK11269
220341001776	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
220341001777	PYR/PP interface [polypeptide binding]; other site
220341001778	dimer interface [polypeptide binding]; other site
220341001779	TPP binding site [chemical binding]; other site
220341001780	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
220341001781	Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006
220341001782	TPP-binding site [chemical binding]; other site
220341001783	hydroxypyruvate isomerase; Provisional; Region: PRK09997
220341001784	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
220341001785	tartronate semialdehyde reductase; Provisional; Region: PRK15059
220341001786	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
220341001787	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833
220341001788	PS00895 3-hydroxyisobutyrate dehydrogenase signature
220341001789	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341001790	Major Facilitator Superfamily; Region: MFS_1; pfam07690
220341001791	putative substrate translocation pore; other site
220341001792	allantoinase; Provisional; Region: PRK08044
220341001793	L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315
220341001794	active site
220341001795	putative uracil/xanthine transporter; Provisional; Region: PRK11412
220341001796	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
220341001797	glycerate kinase II; Provisional; Region: PRK09932
220341001798	PS00017 ATP/GTP-binding site motif A (P-loop)
220341001799	Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257
220341001800	Mif2/CENP-C like; Region: CENP-C_C; pfam11699
220341001801	Cupin domain; Region: Cupin_2; cl17218
220341001802	allantoate amidohydrolase; Region: AllC; TIGR03176
220341001803	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
220341001804	active site
220341001805	metal binding site [ion binding]; metal-binding site
220341001806	dimer interface [polypeptide binding]; other site
220341001807	ureidoglycolate dehydrogenase; Provisional; Region: PRK15025
220341001808	membrane protein FdrA; Validated; Region: PRK06091
220341001809	CoA binding domain; Region: CoA_binding; pfam02629
220341001810	CoA-ligase; Region: Ligase_CoA; pfam00549
220341001811	PS00215 Mitochondrial energy transfer proteins signature
220341001812	Protein of unknown function (DUF1116); Region: DUF1116; pfam06545
220341001813	Protein of unknown function (DUF2877); Region: DUF2877; pfam11392
220341001814	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
220341001815	putative substrate binding site [chemical binding]; other site
220341001816	nucleotide binding site [chemical binding]; other site
220341001817	nucleotide binding site [chemical binding]; other site
220341001818	homodimer interface [polypeptide binding]; other site
220341001819	Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026
220341001820	ATP-grasp domain; Region: ATP-grasp; pfam02222
220341001821	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
220341001822	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
220341001823	putative active site [active]
220341001824	putative metal binding site [ion binding]; other site
220341001825	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
220341001826	substrate binding site [chemical binding]; other site
220341001827	PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature
220341001828	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
220341001829	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
220341001830	active site
220341001831	HIGH motif; other site
220341001832	KMSKS motif; other site
220341001833	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
220341001834	tRNA binding surface [nucleotide binding]; other site
220341001835	anticodon binding site; other site
220341001836	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
220341001837	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
220341001838	RNA binding surface [nucleotide binding]; other site
220341001839	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
220341001840	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
220341001841	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
220341001842	homodimer interface [polypeptide binding]; other site
220341001843	NADP binding site [chemical binding]; other site
220341001844	substrate binding site [chemical binding]; other site
220341001845	PS00767 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2
220341001846	PS00766 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 1
220341001847	PS00017 ATP/GTP-binding site motif A (P-loop)
220341001848	type-1 fimbrial protein subunit A; Provisional; Region: PRK15194
220341001849	fimbrial chaperone protein FimC; Provisional; Region: PRK15195
220341001850	Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345
220341001851	Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753
220341001852	PS00635 Gram-negative pili assembly chaperone signature
220341001853	outer membrane usher protein FimD; Provisional; Region: PRK15198
220341001854	PapC N-terminal domain; Region: PapC_N; pfam13954
220341001855	Outer membrane usher protein; Region: Usher; pfam00577
220341001856	PapC C-terminal domain; Region: PapC_C; pfam13953
220341001857	PS01151 Fimbrial biogenesis outer membrane usher protein signature
220341001858	fimbrial-like adhesin; Provisional; Region: fimH; PRK15199
220341001859	fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934
220341001860	transcriptional regulator FimZ; Provisional; Region: PRK09935
220341001861	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
220341001862	active site
220341001863	phosphorylation site [posttranslational modification]
220341001864	intermolecular recognition site; other site
220341001865	dimerization interface [polypeptide binding]; other site
220341001866	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
220341001867	DNA binding residues [nucleotide binding]
220341001868	dimerization interface [polypeptide binding]; other site
220341001869	PS00622 Bacterial regulatory proteins, luxR family signature
220341001870	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
220341001871	fimbriae regulatory protein FimW; Provisional; Region: PRK15201
220341001872	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
220341001873	DNA binding residues [nucleotide binding]
220341001874	dimerization interface [polypeptide binding]; other site
220341001876	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
220341001877	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
220341001878	Ligand binding site; other site
220341001879	Putative Catalytic site; other site
220341001880	DXD motif; other site
220341001881	Predicted membrane protein [Function unknown]; Region: COG2246
220341001882	Cupin; Region: Cupin_6; pfam12852
220341001883	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
220341001884	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341001885	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341001886	PS00041 Bacterial regulatory proteins, araC family signature
220341001887	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010
220341001888	Squalene epoxidase; Region: SE; cl17314
220341001889	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
220341001890	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
220341001891	PS00017 ATP/GTP-binding site motif A (P-loop)
220341001892	PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site
220341001893	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
220341001894	Predicted membrane protein [Function unknown]; Region: COG3059
220341001895	phenylalanine transporter; Provisional; Region: PRK10249
220341001896	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
220341001897	PS00218 Amino acid permeases signature
220341001898	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
220341001899	Mechanosensitive ion channel; Region: MS_channel; pfam00924
220341001900	Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240
220341001901	Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847
220341001902	active site
220341001903	catalytic triad [active]
220341001904	oxyanion hole [active]
220341001905	Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571
220341001906	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
220341001907	dimer interface [polypeptide binding]; other site
220341001908	FMN binding site [chemical binding]; other site
220341001909	hypothetical protein; Provisional; Region: PRK10250
220341001910	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
220341001911	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
220341001912	PS01081 Bacterial regulatory proteins, tetR family signature
220341001913	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
220341001914	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341001915	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341001916	PS00041 Bacterial regulatory proteins, araC family signature
220341001917	Protein of unknown function (DUF1158); Region: DUF1158; pfam06643
220341001918	gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516
220341001919	phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251
220341001920	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
220341001921	outer membrane receptor FepA; Provisional; Region: PRK13524
220341001922	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
220341001923	N-terminal plug; other site
220341001924	ligand-binding site [chemical binding]; other site
220341001925	PS01156 TonB-dependent receptor proteins signature 2
220341001926	enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439
220341001927	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
220341001928	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187
220341001929	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251
220341001930	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
220341001931	Condensation domain; Region: Condensation; cl19241
220341001932	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
220341001933	acyl-activating enzyme (AAE) consensus motif; other site
220341001934	AMP binding site [chemical binding]; other site
220341001935	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
220341001936	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
220341001937	PS00455 Putative AMP-binding domain signature
220341001938	PS00012 Phosphopantetheine attachment site
220341001939	iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253
220341001940	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
220341001941	Walker A/P-loop; other site
220341001942	ATP binding site [chemical binding]; other site
220341001943	Q-loop/lid; other site
220341001944	ABC transporter signature motif; other site
220341001945	Walker B; other site
220341001946	D-loop; other site
220341001947	H-loop/switch region; other site
220341001948	PS00211 ABC transporters family signature
220341001949	PS00017 ATP/GTP-binding site motif A (P-loop)
220341001950	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
220341001951	ABC-ATPase subunit  interface; other site
220341001952	dimer interface [polypeptide binding]; other site
220341001953	putative PBP binding regions; other site
220341001954	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
220341001955	ABC-ATPase subunit  interface; other site
220341001956	dimer interface [polypeptide binding]; other site
220341001957	putative PBP binding regions; other site
220341001958	enterobactin exporter EntS; Provisional; Region: PRK10489
220341001959	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341001960	putative substrate translocation pore; other site
220341001961	ABC-type Fe2+-enterobactin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG4592
220341001962	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
220341001963	siderophore binding site; other site
220341001964	isochorismate synthase EntC; Provisional; Region: PRK15016
220341001965	chorismate binding enzyme; Region: Chorismate_bind; cl10555
220341001966	enterobactin synthase subunit E; Provisional; Region: entE; PRK10946
220341001967	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
220341001968	acyl-activating enzyme (AAE) consensus motif; other site
220341001969	active site
220341001970	AMP binding site [chemical binding]; other site
220341001971	substrate binding site [chemical binding]; other site
220341001972	PS00455 Putative AMP-binding domain signature
220341001973	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
220341001974	hydrophobic substrate binding pocket; other site
220341001975	active site
220341001976	conserved cis-peptide bond; other site
220341001977	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
220341001978	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
220341001979	2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331
220341001980	putative NAD(P) binding site [chemical binding]; other site
220341001981	active site
220341001982	PS00061 Short-chain dehydrogenases/reductases family signature
220341001983	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
220341001984	CoenzymeA binding site [chemical binding]; other site
220341001985	subunit interaction site [polypeptide binding]; other site
220341001986	PHB binding site; other site
220341001987	carbon starvation protein A; Provisional; Region: PRK15015
220341001988	Carbon starvation protein CstA; Region: CstA; pfam02554
220341001989	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
220341001990	Uncharacterized small protein [Function unknown]; Region: COG2879
220341001991	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
220341001992	putative active site [active]
220341001993	metal binding site [ion binding]; metal-binding site
220341001994	PS00913 Iron-containing alcohol dehydrogenases signature 1
220341001995	methionine aminotransferase; Validated; Region: PRK09082
220341001996	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
220341001997	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341001998	homodimer interface [polypeptide binding]; other site
220341001999	catalytic residue [active]
220341002000	PS00017 ATP/GTP-binding site motif A (P-loop)
220341002001	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
220341002002	ParB-like nuclease domain; Region: ParBc; pfam02195
220341002003	Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969
220341002004	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
220341002005	Active Sites [active]
220341002006	Domain of unknown function (DUF3440); Region: DUF3440; pfam11922
220341002007	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482
220341002008	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341002009	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
220341002010	dimerization interface [polypeptide binding]; other site
220341002011	PS00044 Bacterial regulatory proteins, lysR family signature
220341002012	disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657
220341002013	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
220341002014	dimerization domain [polypeptide binding]; other site
220341002015	dimer interface [polypeptide binding]; other site
220341002016	catalytic residues [active]
220341002017	alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382
220341002018	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
220341002019	dimer interface [polypeptide binding]; other site
220341002020	decamer (pentamer of dimers) interface [polypeptide binding]; other site
220341002021	catalytic triad [active]
220341002022	peroxidatic and resolving cysteines [active]
220341002023	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
220341002024	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
220341002025	catalytic residue [active]
220341002026	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
220341002027	catalytic residues [active]
220341002028	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
220341002029	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
220341002030	PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site
220341002031	Transposase IS200 like; Region: Y1_Tnp; pfam01797
220341002032	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
220341002033	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
220341002034	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
220341002035	putative [4Fe-4S] binding site [ion binding]; other site
220341002036	putative molybdopterin cofactor binding site [chemical binding]; other site
220341002037	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775
220341002038	molybdopterin cofactor binding site; other site
220341002039	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
220341002040	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
220341002041	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341002042	DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302
220341002043	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
220341002044	Ligand Binding Site [chemical binding]; other site
220341002045	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
220341002046	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
220341002047	NAD binding site [chemical binding]; other site
220341002048	catalytic Zn binding site [ion binding]; other site
220341002049	structural Zn binding site [ion binding]; other site
220341002050	PS00059 Zinc-containing alcohol dehydrogenases signature
220341002051	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
220341002052	Rnk N-terminus; Region: Rnk_N; pfam14760
220341002053	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
220341002054	ribonuclease I; Provisional; Region: PRK10095
220341002055	CAS motifs; other site
220341002056	active site
220341002057	PS00531 Ribonuclease T2 family histidine active site 2
220341002058	PS00530 Ribonuclease T2 family histidine active site 1
220341002059	anion transporter; Region: dass; TIGR00785
220341002060	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
220341002061	transmembrane helices; other site
220341002062	triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096
220341002063	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498
220341002064	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
220341002065	Coenzyme A transferase; Region: CoA_trans; cl17247
220341002066	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
220341002067	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
220341002068	Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052
220341002069	Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053
220341002070	Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169
220341002071	putative active site [active]
220341002072	(T/H)XGH motif; other site
220341002073	sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053
220341002074	Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827
220341002075	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
220341002076	putative active site [active]
220341002077	heme pocket [chemical binding]; other site
220341002078	Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689
220341002079	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
220341002080	ATP binding site [chemical binding]; other site
220341002081	Mg2+ binding site [ion binding]; other site
220341002082	G-X-G motif; other site
220341002083	two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046
220341002084	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
220341002085	active site
220341002086	phosphorylation site [posttranslational modification]
220341002087	intermolecular recognition site; other site
220341002088	dimerization interface [polypeptide binding]; other site
220341002089	Transcriptional regulator; Region: CitT; pfam12431
220341002090	C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654
220341002091	C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069
220341002092	phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045
220341002093	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
220341002094	DNA-binding site [nucleotide binding]; DNA binding site
220341002095	RNA-binding motif; other site
220341002096	PS00352 'Cold-shock' DNA-binding domain signature
220341002097	chromosome condensation membrane protein; Provisional; Region: PRK14196
220341002098	PS01227 Uncharacterized protein family UPF0012 signature
220341002099	twin arginine translocase protein E; Validated; Region: tatE; PRK03625
220341002100	lipoyl synthase; Provisional; Region: PRK05481
220341002101	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
220341002102	FeS/SAM binding site; other site
220341002103	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482
220341002104	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341002105	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
220341002106	dimerization interface [polypeptide binding]; other site
220341002107	PS00044 Bacterial regulatory proteins, lysR family signature
220341002108	lipoate-protein ligase B; Provisional; Region: PRK14342
220341002109	PS01313 Lipoate-protein ligase B signature
220341002110	hypothetical protein; Provisional; Region: PRK04998
220341002111	D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793
220341002112	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
220341002113	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
220341002114	rare lipoprotein A; Provisional; Region: PRK10672
220341002115	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
220341002116	Sporulation related domain; Region: SPOR; pfam05036
220341002117	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341002118	cell wall shape-determining protein; Provisional; Region: PRK10794
220341002119	PS00428 Cell cycle proteins ftsW / rodA / spoVE signature
220341002120	penicillin-binding protein 2; Provisional; Region: PRK10795
220341002121	Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717
220341002122	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
220341002123	rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246
220341002124	ribosome-associated protein; Provisional; Region: PRK11538
220341002125	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
220341002126	catalytic core [active]
220341002127	PS00175 Phosphoglycerate mutase family phosphohistidine signature
220341002128	threonine-phosphate decarboxylase; Provisional; Region: PRK08056
220341002129	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
220341002130	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341002131	homodimer interface [polypeptide binding]; other site
220341002132	catalytic residue [active]
220341002133	PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site
220341002134	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
220341002135	active site
220341002136	(T/H)XGH motif; other site
220341002137	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
220341002138	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
220341002139	Processivity clamp loader gamma complex DNA pol III C-term; Region: DNA_pol3_delt_C; pfam14840
220341002140	LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796
220341002141	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341002142	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
220341002143	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
220341002144	active site
220341002145	HIGH motif; other site
220341002146	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
220341002147	KMSKS motif; other site
220341002148	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
220341002149	tRNA binding surface [nucleotide binding]; other site
220341002150	PS00178 Aminoacyl-transfer RNA synthetases class-I signature
220341002151	2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274
220341002152	Propionate catabolism activator; Region: PrpR_N; pfam06506
220341002153	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
220341002154	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
220341002155	Walker A motif; other site
220341002156	ATP binding site [chemical binding]; other site
220341002157	Walker B motif; other site
220341002158	arginine finger; other site
220341002159	PS00675 Sigma-54 interaction domain ATP-binding region A signature
220341002160	PS00688 Sigma-54 interaction domain C-terminal part signature
220341002161	hypothetical protein; Provisional; Region: PRK11032
220341002162	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
220341002163	active site
220341002164	tetramer interface [polypeptide binding]; other site
220341002165	PS01247 Inosine-uridine preferring nucleoside hydrolase family signature
220341002166	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
220341002167	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
220341002168	Walker A/P-loop; other site
220341002169	ATP binding site [chemical binding]; other site
220341002170	Q-loop/lid; other site
220341002171	ABC transporter signature motif; other site
220341002172	Walker B; other site
220341002173	D-loop; other site
220341002174	H-loop/switch region; other site
220341002175	PS00211 ABC transporters family signature
220341002176	PS00017 ATP/GTP-binding site motif A (P-loop)
220341002177	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
220341002178	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341002179	dimer interface [polypeptide binding]; other site
220341002180	conserved gate region; other site
220341002181	putative PBP binding loops; other site
220341002182	ABC-ATPase subunit interface; other site
220341002183	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
220341002184	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341002185	dimer interface [polypeptide binding]; other site
220341002186	conserved gate region; other site
220341002187	putative PBP binding loops; other site
220341002188	ABC-ATPase subunit interface; other site
220341002189	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
220341002190	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
220341002191	substrate binding pocket [chemical binding]; other site
220341002192	membrane-bound complex binding site; other site
220341002193	hinge residues; other site
220341002194	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
220341002195	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
220341002196	putative active site [active]
220341002197	catalytic triad [active]
220341002198	putative dimer interface [polypeptide binding]; other site
220341002199	magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094
220341002200	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
220341002201	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
220341002202	Transporter associated domain; Region: CorC_HlyC; smart01091
220341002203	metal-binding heat shock protein; Provisional; Region: PRK00016
220341002204	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
220341002205	PhoH-like protein; Region: PhoH; pfam02562
220341002206	PS00017 ATP/GTP-binding site motif A (P-loop)
220341002207	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
220341002208	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
220341002209	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
220341002210	FeS/SAM binding site; other site
220341002211	TRAM domain; Region: TRAM; pfam01938
220341002212	PS01278 Uncharacterized protein family UPF0004 signature
220341002213	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020
220341002214	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
220341002215	PS01304 ubiH/COQ6 monooxygenase family signature
220341002216	asparagine synthetase B; Provisional; Region: asnB; PRK09431
220341002217	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
220341002218	active site
220341002219	dimer interface [polypeptide binding]; other site
220341002220	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
220341002221	Ligand Binding Site [chemical binding]; other site
220341002222	Molecular Tunnel; other site
220341002223	UMP phosphatase; Provisional; Region: PRK10444
220341002224	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
220341002225	active site
220341002226	motif I; other site
220341002227	motif II; other site
220341002228	MarR family; Region: MarR_2; cl17246
220341002229	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
220341002230	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
220341002231	nucleotide binding site [chemical binding]; other site
220341002232	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
220341002233	PS01125 ROK family signature
220341002234	N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221
220341002235	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
220341002236	active site
220341002237	dimer interface [polypeptide binding]; other site
220341002238	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
220341002239	active site
220341002240	trimer interface [polypeptide binding]; other site
220341002241	allosteric site; other site
220341002242	active site lid [active]
220341002243	hexamer (dimer of trimers) interface [polypeptide binding]; other site
220341002244	PS01161 Glucosamine/galactosamine-6-phosphate isomerases signature
220341002245	PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255
220341002246	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
220341002247	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
220341002248	active site turn [active]
220341002249	phosphorylation site [posttranslational modification]
220341002250	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
220341002251	HPr interaction site; other site
220341002252	glycerol kinase (GK) interaction site [polypeptide binding]; other site
220341002253	active site
220341002254	phosphorylation site [posttranslational modification]
220341002255	PS01035 PTS EIIB domains cysteine phosphorylation site signature
220341002256	PS00371 PTS EIIA domains phosphorylation site signature 1
220341002257	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
220341002258	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
220341002259	active site
220341002260	HIGH motif; other site
220341002261	KMSKS motif; other site
220341002262	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
220341002263	PS00178 Aminoacyl-transfer RNA synthetases class-I signature
220341002264	outer membrane porin, OprD family; Region: OprD; pfam03573
220341002265	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
220341002266	YbfN-like lipoprotein; Region: YbfN; pfam13982
220341002267	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341002268	citrate-proton symporter; Provisional; Region: PRK15075
220341002269	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341002270	putative substrate translocation pore; other site
220341002271	PS00216 Sugar transport proteins signature 1
220341002272	PS00217 Sugar transport proteins signature 2
220341002273	PS00216 Sugar transport proteins signature 1
220341002274	tricarballylate utilization protein B; Provisional; Region: PRK15033
220341002275	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
220341002276	tricarballylate dehydrogenase; Validated; Region: PRK08274
220341002277	precorrin 3B synthase CobZ; Region: CobZ_N-term; TIGR02485
220341002278	Transcriptional regulator [Transcription]; Region: LysR; COG0583
220341002279	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341002280	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
220341002281	dimerization interface [polypeptide binding]; other site
220341002282	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
220341002283	metal binding site 2 [ion binding]; metal-binding site
220341002284	putative DNA binding helix; other site
220341002285	metal binding site 1 [ion binding]; metal-binding site
220341002286	dimer interface [polypeptide binding]; other site
220341002287	structural Zn2+ binding site [ion binding]; other site
220341002288	flavodoxin FldA; Validated; Region: PRK09267
220341002289	PS00201 Flavodoxin signature
220341002290	LexA regulated protein; Provisional; Region: PRK11675
220341002291	acyl-CoA esterase; Provisional; Region: PRK10673
220341002292	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
220341002293	replication initiation regulator SeqA; Provisional; Region: PRK11187
220341002294	phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132
220341002295	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
220341002296	active site
220341002297	substrate binding site [chemical binding]; other site
220341002298	metal binding site [ion binding]; metal-binding site
220341002299	PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature
220341002300	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
220341002301	putrescine transporter; Provisional; Region: potE; PRK10655
220341002302	PS00017 ATP/GTP-binding site motif A (P-loop)
220341002303	PS00703 Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
220341002304	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
220341002305	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
220341002306	active site
220341002307	phosphorylation site [posttranslational modification]
220341002308	intermolecular recognition site; other site
220341002309	dimerization interface [polypeptide binding]; other site
220341002310	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
220341002311	DNA binding site [nucleotide binding]
220341002312	sensor protein KdpD; Provisional; Region: PRK10490
220341002313	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
220341002314	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
220341002315	Ligand Binding Site [chemical binding]; other site
220341002316	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
220341002317	GAF domain; Region: GAF_3; pfam13492
220341002318	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
220341002319	dimer interface [polypeptide binding]; other site
220341002320	phosphorylation site [posttranslational modification]
220341002321	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
220341002322	ATP binding site [chemical binding]; other site
220341002323	Mg2+ binding site [ion binding]; other site
220341002324	G-X-G motif; other site
220341002325	PS00017 ATP/GTP-binding site motif A (P-loop)
220341002326	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
220341002327	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
220341002328	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
220341002329	Soluble P-type ATPase [General function prediction only]; Region: COG4087
220341002330	PS00402 Binding-protein-dependent transport systems inner membrane comp sign.
220341002331	PS00154 E1-E2 ATPases phosphorylation site
220341002332	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
220341002333	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341002334	Protein of unknown function (DUF2517); Region: DUF2517; pfam10725
220341002335	deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674
220341002336	DNA photolyase; Region: DNA_photolyase; pfam00875
220341002337	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
220341002338	PS00394 DNA photolyases class 1 signature 1
220341002339	PS00691 DNA photolyases class 1 signature 2
220341002340	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
220341002341	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341002342	putative substrate translocation pore; other site
220341002343	PS01023 PTR2 family proton/oligopeptide symporters signature 2
220341002344	PS01022 PTR2 family proton/oligopeptide symporters signature 1
220341002345	metal-binding protein; Provisional; Region: PRK10799
220341002346	Allophanate hydrolase subunit 1; Region: AHS1; cl19310
220341002347	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
220341002348	Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800
220341002349	putative active site [active]
220341002350	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
220341002351	active site
220341002352	DNA binding site [nucleotide binding]
220341002353	Int/Topo IB signature motif; other site
220341002354	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
220341002355	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
220341002356	active site
220341002357	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
220341002358	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
220341002359	putative ADP-binding pocket [chemical binding]; other site
220341002360	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
220341002361	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
220341002362	Walker A/P-loop; other site
220341002363	ATP binding site [chemical binding]; other site
220341002364	Q-loop/lid; other site
220341002365	ABC transporter signature motif; other site
220341002366	Walker B; other site
220341002367	D-loop; other site
220341002368	H-loop/switch region; other site
220341002369	PS00017 ATP/GTP-binding site motif A (P-loop)
220341002370	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
220341002371	active site
220341002372	endonuclease VIII; Provisional; Region: PRK10445
220341002373	N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965
220341002374	DNA binding site [nucleotide binding]
220341002375	catalytic residue [active]
220341002376	putative catalytic residues [active]
220341002377	H2TH interface [polypeptide binding]; other site
220341002378	intercalation triad [nucleotide binding]; other site
220341002379	substrate specificity determining residue; other site
220341002380	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
220341002381	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
220341002382	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
220341002383	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
220341002384	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
220341002385	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
220341002386	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
220341002387	dimer interface [polypeptide binding]; other site
220341002388	active site
220341002389	citrylCoA binding site [chemical binding]; other site
220341002390	NADH binding [chemical binding]; other site
220341002391	cationic pore residues; other site
220341002392	oxalacetate/citrate binding site [chemical binding]; other site
220341002393	coenzyme A binding site [chemical binding]; other site
220341002394	catalytic triad [active]
220341002395	PS00480 Citrate synthase signature
220341002396	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
220341002397	Iron-sulfur protein interface; other site
220341002398	proximal quinone binding site [chemical binding]; other site
220341002399	SdhD (CybS) interface [polypeptide binding]; other site
220341002400	proximal heme binding site [chemical binding]; other site
220341002401	PS01000 Succinate dehydrogenase cytochrome b subunit signature 1
220341002402	PS01001 Succinate dehydrogenase cytochrome b subunit signature 2
220341002403	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
220341002404	SdhC subunit interface [polypeptide binding]; other site
220341002405	proximal heme binding site [chemical binding]; other site
220341002406	cardiolipin binding site; other site
220341002407	Iron-sulfur protein interface; other site
220341002408	proximal quinone binding site [chemical binding]; other site
220341002409	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958
220341002410	L-aspartate oxidase; Provisional; Region: PRK06175
220341002411	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
220341002412	PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site
220341002413	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
220341002414	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
220341002415	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
220341002416	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341002417	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
220341002418	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
220341002419	TPP-binding site [chemical binding]; other site
220341002420	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
220341002421	dimer interface [polypeptide binding]; other site
220341002422	PYR/PP interface [polypeptide binding]; other site
220341002423	TPP binding site [chemical binding]; other site
220341002424	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
220341002425	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
220341002426	E3 interaction surface; other site
220341002427	lipoyl attachment site [posttranslational modification]; other site
220341002428	e3 binding domain; Region: E3_binding; pfam02817
220341002429	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
220341002430	PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site
220341002431	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
220341002432	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
220341002433	CoA-ligase; Region: Ligase_CoA; pfam00549
220341002434	PS01217 ATP-citrate lyase / succinyl-CoA ligases family signature 3
220341002435	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
220341002436	CoA binding domain; Region: CoA_binding; pfam02629
220341002437	CoA-ligase; Region: Ligase_CoA; pfam00549
220341002438	PS01216 ATP-citrate lyase / succinyl-CoA ligases family signature 1
220341002439	PS00399 ATP-citrate lyase / succinyl-CoA ligases family active site
220341002440	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
220341002441	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003
220341002442	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
220341002443	Predicted outer membrane lipoprotein [Function unknown]; Region: COG4890
220341002444	hypothetical protein; Provisional; Region: PRK10588
220341002445	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
220341002446	active site
220341002447	colicin uptake protein TolQ; Provisional; Region: PRK10801
220341002448	colicin uptake protein TolR; Provisional; Region: PRK11024
220341002449	cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510
220341002450	TolA C-terminal; Region: TolA; pfam06519
220341002451	translocation protein TolB; Provisional; Region: tolB; PRK03629
220341002452	TolB amino-terminal domain; Region: TolB_N; pfam04052
220341002453	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
220341002454	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
220341002455	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
220341002456	peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802
220341002457	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
220341002458	ligand binding site [chemical binding]; other site
220341002459	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341002460	PS01068 OmpA-like domain
220341002461	tol-pal system protein YbgF; Provisional; Region: PRK10803
220341002462	Tetratricopeptide repeat; Region: TPR_6; pfam13174
220341002463	Tetratricopeptide repeat; Region: TPR_6; pfam13174
220341002464	quinolinate synthetase; Provisional; Region: PRK09375
220341002465	nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397
220341002466	zinc transporter ZitB; Provisional; Region: PRK03557
220341002467	PS00511 Corticotropin-releasing factor family signature
220341002468	YbgS-like protein; Region: YbgS; pfam13985
220341002469	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
220341002470	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
220341002471	ABC-ATPase subunit  interface; other site
220341002472	dimer interface [polypeptide binding]; other site
220341002473	putative PBP binding regions; other site
220341002474	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
220341002475	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
220341002476	Walker A/P-loop; other site
220341002477	ATP binding site [chemical binding]; other site
220341002478	Q-loop/lid; other site
220341002479	ABC transporter signature motif; other site
220341002480	Walker B; other site
220341002481	D-loop; other site
220341002482	H-loop/switch region; other site
220341002483	PS00017 ATP/GTP-binding site motif A (P-loop)
220341002484	PS00211 ABC transporters family signature
220341002485	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
220341002486	catalytic core [active]
220341002487	PS00175 Phosphoglycerate mutase family phosphohistidine signature
220341002488	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
220341002489	active site
220341002490	catalytic residues [active]
220341002491	PS00545 Aldose 1-epimerase putative active site
220341002492	galactokinase; Provisional; Region: PRK05101
220341002493	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
220341002494	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
220341002495	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
220341002496	PS00627 GHMP kinases putative ATP-binding domain
220341002497	PS00106 Galactokinase signature
220341002498	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
220341002499	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
220341002500	dimer interface [polypeptide binding]; other site
220341002501	active site
220341002502	PS00117 Galactose-1-phosphate uridyl transferase family 1 active site signature
220341002503	UDP-galactose-4-epimerase; Provisional; Region: PRK10675
220341002504	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
220341002505	NAD binding site [chemical binding]; other site
220341002506	homodimer interface [polypeptide binding]; other site
220341002507	active site
220341002508	substrate binding site [chemical binding]; other site
220341002509	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4714
220341002510	putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938
220341002511	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
220341002512	Walker A/P-loop; other site
220341002513	ATP binding site [chemical binding]; other site
220341002514	Q-loop/lid; other site
220341002515	ABC transporter signature motif; other site
220341002516	Walker B; other site
220341002517	D-loop; other site
220341002518	H-loop/switch region; other site
220341002519	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
220341002520	Walker A/P-loop; other site
220341002521	ATP binding site [chemical binding]; other site
220341002522	Q-loop/lid; other site
220341002523	ABC transporter signature motif; other site
220341002524	Walker B; other site
220341002525	D-loop; other site
220341002526	H-loop/switch region; other site
220341002527	PS00017 ATP/GTP-binding site motif A (P-loop)
220341002528	PS00017 ATP/GTP-binding site motif A (P-loop)
220341002529	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
220341002530	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
220341002531	molybdenum-pterin binding domain; Region: Mop; TIGR00638
220341002532	TOBE domain; Region: TOBE; pfam03459
220341002533	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
220341002534	substrate binding pocket [chemical binding]; other site
220341002535	membrane-bound complex binding site; other site
220341002536	hinge residues; other site
220341002537	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
220341002538	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341002539	dimer interface [polypeptide binding]; other site
220341002540	conserved gate region; other site
220341002541	putative PBP binding loops; other site
220341002542	ABC-ATPase subunit interface; other site
220341002543	PS00402 Binding-protein-dependent transport systems inner membrane comp sign.
220341002544	molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144
220341002545	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
220341002546	Walker A/P-loop; other site
220341002547	ATP binding site [chemical binding]; other site
220341002548	Q-loop/lid; other site
220341002549	ABC transporter signature motif; other site
220341002550	Walker B; other site
220341002551	D-loop; other site
220341002552	H-loop/switch region; other site
220341002553	molybdenum-pterin binding domain; Region: Mop; TIGR00638
220341002554	PS00017 ATP/GTP-binding site motif A (P-loop)
220341002555	PS00211 ABC transporters family signature
220341002556	pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530
220341002557	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
220341002558	active site
220341002559	motif I; other site
220341002560	motif II; other site
220341002561	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
220341002562	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; cl17774
220341002563	6-phosphogluconolactonase; Provisional; Region: PRK11028
220341002564	acyl-CoA thioesterase; Provisional; Region: PRK10531
220341002565	Pectinesterase; Region: Pectinesterase; cl01911
220341002566	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341002567	imidazolonepropionase; Validated; Region: PRK09356
220341002568	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
220341002569	active site
220341002570	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
220341002571	putative active site [active]
220341002572	putative metal binding site [ion binding]; other site
220341002573	PS00147 Arginase family signature 1
220341002574	PS00148 Arginase family signature 2
220341002575	histidine utilization repressor; Provisional; Region: PRK14999
220341002576	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
220341002577	DNA-binding site [nucleotide binding]; DNA binding site
220341002578	UTRA domain; Region: UTRA; pfam07702
220341002579	PS00043 Bacterial regulatory proteins, gntR family signature
220341002580	urocanate hydratase; Provisional; Region: PRK05414
220341002581	PS01233 Urocanase active site
220341002582	Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221
220341002583	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
220341002584	active sites [active]
220341002585	tetramer interface [polypeptide binding]; other site
220341002586	PS00488 Phenylalanine and histidine ammonia-lyases signature
220341002587	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
220341002588	substrate binding site [chemical binding]; other site
220341002589	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
220341002590	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
220341002591	inhibitor-cofactor binding pocket; inhibition site
220341002592	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341002593	catalytic residue [active]
220341002594	PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site
220341002595	biotin synthase; Provisional; Region: PRK15108
220341002596	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
220341002597	FeS/SAM binding site; other site
220341002598	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
220341002599	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341002600	8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858
220341002601	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
220341002602	substrate-cofactor binding pocket; other site
220341002603	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341002604	catalytic residue [active]
220341002605	PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site
220341002606	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
220341002607	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
220341002608	S-adenosylmethionine binding site [chemical binding]; other site
220341002609	AAA domain; Region: AAA_26; pfam13500
220341002610	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
220341002611	excinuclease ABC subunit B; Provisional; Region: PRK05298
220341002612	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
220341002613	ATP binding site [chemical binding]; other site
220341002614	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
220341002615	nucleotide binding region [chemical binding]; other site
220341002616	ATP-binding site [chemical binding]; other site
220341002617	Ultra-violet resistance protein B; Region: UvrB; pfam12344
220341002618	UvrB/uvrC motif; Region: UVR; pfam02151
220341002619	PS00017 ATP/GTP-binding site motif A (P-loop)
220341002620	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
220341002621	phosphate binding site [ion binding]; other site
220341002622	putative substrate binding pocket [chemical binding]; other site
220341002623	dimer interface [polypeptide binding]; other site
220341002624	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
220341002625	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
220341002626	FeS/SAM binding site; other site
220341002627	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
220341002628	PS01305 moaA / nifB / pqqE family signature
220341002629	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
220341002630	MPT binding site; other site
220341002631	trimer interface [polypeptide binding]; other site
220341002632	PS01078 Molybdenum cofactor biosynthesis proteins signature 1
220341002633	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
220341002634	trimer interface [polypeptide binding]; other site
220341002635	dimer interface [polypeptide binding]; other site
220341002636	putative active site [active]
220341002637	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
220341002638	MoaE interaction surface [polypeptide binding]; other site
220341002639	MoeB interaction surface [polypeptide binding]; other site
220341002640	thiocarboxylated glycine; other site
220341002641	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
220341002642	MoaE homodimer interface [polypeptide binding]; other site
220341002643	MoaD interaction [polypeptide binding]; other site
220341002644	active site residues [active]
220341002645	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
220341002646	Predicted integral membrane protein [Function unknown]; Region: COG0392
220341002647	cardiolipin synthase 2; Provisional; Region: PRK11263
220341002648	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
220341002649	putative active site [active]
220341002650	catalytic site [active]
220341002651	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
220341002652	putative active site [active]
220341002653	catalytic site [active]
220341002654	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
220341002655	putative catalytic site [active]
220341002656	putative metal binding site [ion binding]; other site
220341002657	putative phosphate binding site [ion binding]; other site
220341002658	Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076
220341002659	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580
220341002660	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
220341002661	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
220341002662	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
220341002663	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
220341002664	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
220341002665	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
220341002666	Walker A/P-loop; other site
220341002667	ATP binding site [chemical binding]; other site
220341002668	Q-loop/lid; other site
220341002669	ABC transporter signature motif; other site
220341002670	Walker B; other site
220341002671	D-loop; other site
220341002672	H-loop/switch region; other site
220341002673	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
220341002674	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
220341002675	Walker A/P-loop; other site
220341002676	ATP binding site [chemical binding]; other site
220341002677	Q-loop/lid; other site
220341002678	ABC transporter signature motif; other site
220341002679	Walker B; other site
220341002680	D-loop; other site
220341002681	H-loop/switch region; other site
220341002682	PS00017 ATP/GTP-binding site motif A (P-loop)
220341002683	PS00211 ABC transporters family signature
220341002684	PS00017 ATP/GTP-binding site motif A (P-loop)
220341002685	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
220341002686	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
220341002687	HlyD family secretion protein; Region: HlyD_3; pfam13437
220341002688	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552
220341002689	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
220341002690	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
220341002691	PS01081 Bacterial regulatory proteins, tetR family signature
220341002692	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
220341002693	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
220341002694	ATP binding site [chemical binding]; other site
220341002695	Mg++ binding site [ion binding]; other site
220341002696	motif III; other site
220341002697	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
220341002698	nucleotide binding region [chemical binding]; other site
220341002699	ATP-binding site [chemical binding]; other site
220341002700	PS00017 ATP/GTP-binding site motif A (P-loop)
220341002701	PS00039 DEAD-box subfamily ATP-dependent helicases signature
220341002702	PS00017 ATP/GTP-binding site motif A (P-loop)
220341002703	hypothetical protein; Provisional; Region: PRK10259
220341002704	hypothetical protein; Provisional; Region: PRK11019
220341002705	PS01102 Prokaryotic dksA/traR C4-type zinc finger
220341002706	putative mechanosensitive channel protein; Provisional; Region: PRK11465
220341002707	Mechanosensitive ion channel; Region: MS_channel; pfam00924
220341002708	glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493
220341002709	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
220341002710	Walker A/P-loop; other site
220341002711	ATP binding site [chemical binding]; other site
220341002712	Q-loop/lid; other site
220341002713	ABC transporter signature motif; other site
220341002714	Walker B; other site
220341002715	D-loop; other site
220341002716	H-loop/switch region; other site
220341002717	PS00211 ABC transporters family signature
220341002718	PS00017 ATP/GTP-binding site motif A (P-loop)
220341002719	glutamine ABC transporter permease protein; Reviewed; Region: glnP; PRK09494
220341002720	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341002721	dimer interface [polypeptide binding]; other site
220341002722	conserved gate region; other site
220341002723	putative PBP binding loops; other site
220341002724	ABC-ATPase subunit interface; other site
220341002725	PS00402 Binding-protein-dependent transport systems inner membrane comp sign.
220341002726	glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495
220341002727	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
220341002728	substrate binding pocket [chemical binding]; other site
220341002729	membrane-bound complex binding site; other site
220341002730	hinge residues; other site
220341002731	PS01039 Bacterial extracellular solute-binding proteins, family 3 signature
220341002732	Ferritin-like domain; Region: Ferritin; pfam00210
220341002733	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
220341002734	dimerization interface [polypeptide binding]; other site
220341002735	DPS ferroxidase diiron center [ion binding]; other site
220341002736	ion pore; other site
220341002737	PS00819 Dps protein family signature 2
220341002738	PS00818 Dps protein family signature 1
220341002739	threonine and homoserine efflux system; Provisional; Region: PRK10532
220341002740	EamA-like transporter family; Region: EamA; pfam00892
220341002741	outer membrane protein X; Provisional; Region: ompX; PRK09408
220341002742	PS00694 Enterobacterial virulence outer membrane protein signature 1
220341002743	PS00695 Enterobacterial virulence outer membrane protein signature 2
220341002744	Transposase IS200 like; Region: Y1_Tnp; pfam01797
220341002745	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
220341002746	Sulfatase; Region: Sulfatase; pfam00884
220341002747	manganese transport regulator MntR; Provisional; Region: PRK11050
220341002748	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
220341002749	Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742
220341002750	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
220341002751	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
220341002752	transmembrane helices; other site
220341002753	L,D-transpeptidase; Provisional; Region: PRK10260
220341002754	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
220341002755	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
220341002756	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
220341002757	ABC transporter; Region: ABC_tran_2; pfam12848
220341002758	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
220341002759	PS00017 ATP/GTP-binding site motif A (P-loop)
220341002760	PS00017 ATP/GTP-binding site motif A (P-loop)
220341002761	Protein of unknown function (DUF1479); Region: DUF1479; pfam07350
220341002762	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
220341002763	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
220341002764	active site
220341002765	motif I; other site
220341002766	motif II; other site
220341002767	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
220341002768	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
220341002769	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
220341002770	dimer interface [polypeptide binding]; other site
220341002771	active site
220341002772	glycine loop; other site
220341002773	PS00850 Glycine radical signature
220341002774	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
220341002775	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962
220341002776	PS01087 Radical activating enzymes signature
220341002777	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
220341002778	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
220341002779	ATP binding site [chemical binding]; other site
220341002780	substrate interface [chemical binding]; other site
220341002781	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
220341002782	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
220341002783	dimer interface [polypeptide binding]; other site
220341002784	putative functional site; other site
220341002785	putative MPT binding site; other site
220341002786	PS01079 Molybdenum cofactor biosynthesis proteins signature 2
220341002787	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
220341002788	catalytic nucleophile [active]
220341002789	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341002790	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
220341002791	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
220341002792	Walker A/P-loop; other site
220341002793	ATP binding site [chemical binding]; other site
220341002794	Q-loop/lid; other site
220341002795	ABC transporter signature motif; other site
220341002796	Walker B; other site
220341002797	D-loop; other site
220341002798	H-loop/switch region; other site
220341002799	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
220341002800	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
220341002801	Walker A/P-loop; other site
220341002802	ATP binding site [chemical binding]; other site
220341002803	Q-loop/lid; other site
220341002804	ABC transporter signature motif; other site
220341002805	Walker B; other site
220341002806	D-loop; other site
220341002807	H-loop/switch region; other site
220341002808	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
220341002809	PS00017 ATP/GTP-binding site motif A (P-loop)
220341002810	PS00211 ABC transporters family signature
220341002811	PS00017 ATP/GTP-binding site motif A (P-loop)
220341002812	PS00211 ABC transporters family signature
220341002813	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
220341002814	The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499
220341002815	glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081
220341002816	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341002817	dimer interface [polypeptide binding]; other site
220341002818	conserved gate region; other site
220341002819	putative PBP binding loops; other site
220341002820	ABC-ATPase subunit interface; other site
220341002821	PS00402 Binding-protein-dependent transport systems inner membrane comp sign.
220341002822	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
220341002823	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
220341002824	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341002825	dimer interface [polypeptide binding]; other site
220341002826	conserved gate region; other site
220341002827	putative PBP binding loops; other site
220341002828	ABC-ATPase subunit interface; other site
220341002829	PS00402 Binding-protein-dependent transport systems inner membrane comp sign.
220341002830	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
220341002831	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
220341002832	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
220341002833	FeS/SAM binding site; other site
220341002834	biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302
220341002835	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645
220341002836	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
220341002837	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
220341002838	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
220341002839	putative C-terminal domain interface [polypeptide binding]; other site
220341002840	putative GSH binding site (G-site) [chemical binding]; other site
220341002841	putative dimer interface [polypeptide binding]; other site
220341002842	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
220341002843	N-terminal domain interface [polypeptide binding]; other site
220341002844	dimer interface [polypeptide binding]; other site
220341002845	substrate binding pocket (H-site) [chemical binding]; other site
220341002846	D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001
220341002847	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
220341002848	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
220341002849	DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681
220341002850	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
220341002851	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
220341002852	PS00894 Bacterial regulatory proteins
220341002853	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
220341002854	PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385
220341002855	active site
220341002856	multidrug efflux system translocase MdfA; Provisional; Region: PRK15402
220341002857	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341002858	putative substrate translocation pore; other site
220341002859	PS00216 Sugar transport proteins signature 1
220341002860	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
220341002861	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
220341002862	active site
220341002863	motif I; other site
220341002864	motif II; other site
220341002865	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
220341002866	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
220341002867	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341002868	putative substrate translocation pore; other site
220341002869	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
220341002870	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
220341002871	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
220341002872	putative transporter; Provisional; Region: PRK04972
220341002873	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
220341002874	TrkA-C domain; Region: TrkA_C; pfam02080
220341002875	TrkA-C domain; Region: TrkA_C; pfam02080
220341002876	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
220341002877	Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045
220341002878	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
220341002879	GSH binding site [chemical binding]; other site
220341002880	catalytic residues [active]
220341002881	PS00195 Glutaredoxin active site
220341002882	Protein of unknown function (DUF1418); Region: DUF1418; pfam07214
220341002883	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
220341002884	dimer interface [polypeptide binding]; other site
220341002885	FMN binding site [chemical binding]; other site
220341002886	NADPH bind site [chemical binding]; other site
220341002887	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
220341002888	RimK-like ATP-grasp domain; Region: RimK; pfam08443
220341002889	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
220341002890	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
220341002891	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
220341002892	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
220341002893	Walker A/P-loop; other site
220341002894	ATP binding site [chemical binding]; other site
220341002895	Q-loop/lid; other site
220341002896	ABC transporter signature motif; other site
220341002897	Walker B; other site
220341002898	D-loop; other site
220341002899	H-loop/switch region; other site
220341002900	TOBE domain; Region: TOBE_2; pfam08402
220341002901	PS00017 ATP/GTP-binding site motif A (P-loop)
220341002902	PS00211 ABC transporters family signature
220341002903	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341002904	dimer interface [polypeptide binding]; other site
220341002905	conserved gate region; other site
220341002906	putative PBP binding loops; other site
220341002907	ABC-ATPase subunit interface; other site
220341002908	PS00402 Binding-protein-dependent transport systems inner membrane comp sign.
220341002909	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
220341002910	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341002911	dimer interface [polypeptide binding]; other site
220341002912	conserved gate region; other site
220341002913	putative PBP binding loops; other site
220341002914	ABC-ATPase subunit interface; other site
220341002915	PS00402 Binding-protein-dependent transport systems inner membrane comp sign.
220341002916	Protein of unknown function (DUF2593); Region: DUF2593; pfam10767
220341002917	23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085
220341002918	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
220341002919	S-adenosylmethionine binding site [chemical binding]; other site
220341002920	PS01230 RNA methyltransferase trmA family signature 1
220341002921	PS01231 RNA methyltransferase trmA family signature 2
220341002922	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
220341002923	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
220341002924	active site
220341002925	P-loop; other site
220341002926	phosphorylation site [posttranslational modification]
220341002927	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
220341002928	Sulfatase; Region: Sulfatase; cl19157
220341002929	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
220341002930	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
220341002931	substrate binding pocket [chemical binding]; other site
220341002932	membrane-bound complex binding site; other site
220341002933	hinge residues; other site
220341002934	PS01039 Bacterial extracellular solute-binding proteins, family 3 signature
220341002935	arginine transporter permease subunit ArtM; Provisional; Region: artM; PRK11122
220341002936	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341002937	dimer interface [polypeptide binding]; other site
220341002938	conserved gate region; other site
220341002939	putative PBP binding loops; other site
220341002940	ABC-ATPase subunit interface; other site
220341002941	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
220341002942	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341002943	dimer interface [polypeptide binding]; other site
220341002944	conserved gate region; other site
220341002945	putative PBP binding loops; other site
220341002946	ABC-ATPase subunit interface; other site
220341002947	PS00402 Binding-protein-dependent transport systems inner membrane comp sign.
220341002948	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
220341002949	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
220341002950	substrate binding pocket [chemical binding]; other site
220341002951	membrane-bound complex binding site; other site
220341002952	hinge residues; other site
220341002953	PS01039 Bacterial extracellular solute-binding proteins, family 3 signature
220341002954	arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124
220341002955	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
220341002956	Walker A/P-loop; other site
220341002957	ATP binding site [chemical binding]; other site
220341002958	Q-loop/lid; other site
220341002959	ABC transporter signature motif; other site
220341002960	Walker B; other site
220341002961	D-loop; other site
220341002962	H-loop/switch region; other site
220341002963	PS00211 ABC transporters family signature
220341002964	PS00017 ATP/GTP-binding site motif A (P-loop)
220341002965	putative lipoprotein; Provisional; Region: PRK10533
220341002966	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341002967	hypothetical protein; Provisional; Region: PRK02877
220341002968	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
220341002969	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
220341002970	amidase catalytic site [active]
220341002971	Zn binding residues [ion binding]; other site
220341002972	substrate binding site [chemical binding]; other site
220341002973	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341002974	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
220341002975	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
220341002976	NAD(P) binding site [chemical binding]; other site
220341002977	active site
220341002978	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
220341002979	atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245
220341002980	putative NAD(P) binding site [chemical binding]; other site
220341002981	putative active site [active]
220341002982	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
220341002983	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
220341002984	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
220341002985	tetramer interface [polypeptide binding]; other site
220341002986	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341002987	catalytic residue [active]
220341002988	pyruvate dehydrogenase; Provisional; Region: PRK09124
220341002989	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
220341002990	PYR/PP interface [polypeptide binding]; other site
220341002991	dimer interface [polypeptide binding]; other site
220341002992	tetramer interface [polypeptide binding]; other site
220341002993	TPP binding site [chemical binding]; other site
220341002994	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
220341002995	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
220341002996	TPP-binding site [chemical binding]; other site
220341002997	PS00187 Thiamine pyrophosphate enzymes signature
220341002998	HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684
220341002999	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
220341003000	FAD binding pocket [chemical binding]; other site
220341003001	FAD binding motif [chemical binding]; other site
220341003002	phosphate binding motif [ion binding]; other site
220341003003	beta-alpha-beta structure motif; other site
220341003004	NAD binding pocket [chemical binding]; other site
220341003005	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
220341003006	catalytic loop [active]
220341003007	iron binding site [ion binding]; other site
220341003008	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
220341003009	cubane metal cluster [ion binding]; other site
220341003010	hybrid metal cluster; other site
220341003011	PS00017 ATP/GTP-binding site motif A (P-loop)
220341003012	Predicted membrane protein [Function unknown]; Region: COG2431
220341003013	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
220341003014	AAA domain; Region: AAA_21; pfam13304
220341003015	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
220341003016	putative active site [active]
220341003017	putative metal-binding site [ion binding]; other site
220341003018	PS00017 ATP/GTP-binding site motif A (P-loop)
220341003019	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990
220341003020	macrolide transporter subunit MacA; Provisional; Region: PRK11578
220341003021	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
220341003022	HlyD family secretion protein; Region: HlyD_3; pfam13437
220341003023	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
220341003024	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
220341003025	Walker A/P-loop; other site
220341003026	ATP binding site [chemical binding]; other site
220341003027	Q-loop/lid; other site
220341003028	ABC transporter signature motif; other site
220341003029	Walker B; other site
220341003030	D-loop; other site
220341003031	H-loop/switch region; other site
220341003032	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
220341003033	FtsX-like permease family; Region: FtsX; pfam02687
220341003034	PS00017 ATP/GTP-binding site motif A (P-loop)
220341003035	PS00211 ABC transporters family signature
220341003036	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
220341003037	DNA-binding site [nucleotide binding]; DNA binding site
220341003038	RNA-binding motif; other site
220341003039	PS00352 'Cold-shock' DNA-binding domain signature
220341003040	Uncharacterized conserved protein [Function unknown]; Region: COG2127
220341003041	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
220341003042	Clp amino terminal domain; Region: Clp_N; pfam02861
220341003043	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
220341003044	Walker A motif; other site
220341003045	ATP binding site [chemical binding]; other site
220341003046	Walker B motif; other site
220341003047	arginine finger; other site
220341003048	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
220341003049	Walker A motif; other site
220341003050	ATP binding site [chemical binding]; other site
220341003051	Walker B motif; other site
220341003052	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
220341003053	PS00017 ATP/GTP-binding site motif A (P-loop)
220341003054	PS00870 Chaperonins clpA/B signature 1
220341003055	PS00017 ATP/GTP-binding site motif A (P-loop)
220341003056	PS00871 Chaperonins clpA/B signature 2
220341003057	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
220341003058	catalytic triad [active]
220341003059	dimer interface [polypeptide binding]; other site
220341003060	conserved cis-peptide bond; other site
220341003061	Pirin-related protein [General function prediction only]; Region: COG1741
220341003062	Pirin; Region: Pirin; pfam02678
220341003063	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
220341003064	LysR family transcriptional regulator; Provisional; Region: PRK14997
220341003065	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341003066	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
220341003067	putative effector binding pocket; other site
220341003068	putative dimerization interface [polypeptide binding]; other site
220341003069	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
220341003070	rRNA binding site [nucleotide binding]; other site
220341003071	predicted 30S ribosome binding site; other site
220341003072	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
220341003073	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
220341003074	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
220341003075	ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247
220341003076	Walker A/P-loop; other site
220341003077	ATP binding site [chemical binding]; other site
220341003078	Q-loop/lid; other site
220341003079	ABC transporter signature motif; other site
220341003080	Walker B; other site
220341003081	D-loop; other site
220341003082	H-loop/switch region; other site
220341003083	PS00211 ABC transporters family signature
220341003084	PS00017 ATP/GTP-binding site motif A (P-loop)
220341003085	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
220341003086	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
220341003087	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
220341003088	Walker A/P-loop; other site
220341003089	ATP binding site [chemical binding]; other site
220341003090	Q-loop/lid; other site
220341003091	ABC transporter signature motif; other site
220341003092	Walker B; other site
220341003093	D-loop; other site
220341003094	H-loop/switch region; other site
220341003095	PS00211 ABC transporters family signature
220341003096	PS00017 ATP/GTP-binding site motif A (P-loop)
220341003097	thioredoxin reductase; Provisional; Region: PRK10262
220341003098	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
220341003099	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
220341003100	PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site
220341003101	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
220341003102	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
220341003103	putative DNA binding site [nucleotide binding]; other site
220341003104	putative Zn2+ binding site [ion binding]; other site
220341003105	AsnC family; Region: AsnC_trans_reg; pfam01037
220341003106	PS00519 Bacterial regulatory proteins, asnC family signature
220341003107	DNA translocase FtsK; Provisional; Region: PRK10263
220341003108	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341003109	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
220341003110	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
220341003111	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
220341003112	PS00017 ATP/GTP-binding site motif A (P-loop)
220341003113	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl19192
220341003114	recombination factor protein RarA; Reviewed; Region: PRK13342
220341003115	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
220341003116	Walker A motif; other site
220341003117	ATP binding site [chemical binding]; other site
220341003118	Walker B motif; other site
220341003119	arginine finger; other site
220341003120	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
220341003121	PS00017 ATP/GTP-binding site motif A (P-loop)
220341003122	seryl-tRNA synthetase; Provisional; Region: PRK05431
220341003123	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
220341003124	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
220341003125	dimer interface [polypeptide binding]; other site
220341003126	active site
220341003127	motif 1; other site
220341003128	motif 2; other site
220341003129	motif 3; other site
220341003130	PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1
220341003131	anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990
220341003132	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
220341003133	putative [Fe4-S4] binding site [ion binding]; other site
220341003134	putative molybdopterin cofactor binding site [chemical binding]; other site
220341003135	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
220341003136	putative molybdopterin cofactor binding site; other site
220341003137	PS00551 Prokaryotic molybdopterin oxidoreductases signature 1
220341003138	PS00490 Prokaryotic molybdopterin oxidoreductases signature 2
220341003139	PS00932 Prokaryotic molybdopterin oxidoreductases signature 3
220341003140	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
220341003141	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
220341003142	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341003143	PS00190 Cytochrome c family heme-binding site signature
220341003144	DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976
220341003145	putative MFS family transporter protein; Provisional; Region: PRK03633
220341003146	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341003147	putative substrate translocation pore; other site
220341003148	inner membrane transporter YjeM; Provisional; Region: PRK15238
220341003149	pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145
220341003150	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
220341003151	FeS/SAM binding site; other site
220341003152	PS01087 Radical activating enzymes signature
220341003153	PS00190 Cytochrome c family heme-binding site signature
220341003154	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
220341003155	Pyruvate formate lyase 1; Region: PFL1; cd01678
220341003156	coenzyme A binding site [chemical binding]; other site
220341003157	active site
220341003158	catalytic residues [active]
220341003159	glycine loop; other site
220341003160	PS00850 Glycine radical signature
220341003161	formate transporter; Provisional; Region: PRK10805
220341003162	PS01006 Formate and nitrite transporters signature 2
220341003163	PS01005 Formate and nitrite transporters signature 1
220341003164	uncharacterized domain; Region: TIGR00702
220341003165	Predicted membrane protein [Function unknown]; Region: COG2323
220341003166	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
220341003167	homodimer interface [polypeptide binding]; other site
220341003168	substrate-cofactor binding pocket; other site
220341003169	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341003170	catalytic residue [active]
220341003171	PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site
220341003172	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
220341003173	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
220341003174	putative active site [active]
220341003175	PS00017 ATP/GTP-binding site motif A (P-loop)
220341003176	PS00104 EPSP synthase signature 1
220341003177	PS00885 EPSP synthase signature 2
220341003178	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
220341003179	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341003180	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature
220341003181	cytidylate kinase; Provisional; Region: cmk; PRK00023
220341003182	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
220341003183	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
220341003184	active site
220341003185	CMP-binding site; other site
220341003186	The sites determining sugar specificity; other site
220341003187	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
220341003188	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
220341003189	RNA binding site [nucleotide binding]; other site
220341003190	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
220341003191	RNA binding site [nucleotide binding]; other site
220341003192	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
220341003193	RNA binding site [nucleotide binding]; other site
220341003194	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
220341003195	RNA binding site [nucleotide binding]; other site
220341003196	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
220341003197	RNA binding site [nucleotide binding]; other site
220341003198	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
220341003199	RNA binding site [nucleotide binding]; other site
220341003200	Beta subunit of integration host factor (IHFB); Region: IHF_B; cd13836
220341003201	dimer interface [polypeptide binding]; other site
220341003202	DNA binding site [nucleotide binding]
220341003203	PS00045 Bacterial histone-like DNA-binding proteins signature
220341003204	ComEC family competence protein; Provisional; Region: PRK11539
220341003205	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
220341003206	Competence protein; Region: Competence; pfam03772
220341003207	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
220341003208	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
220341003209	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
220341003210	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
220341003211	Walker A/P-loop; other site
220341003212	ATP binding site [chemical binding]; other site
220341003213	Q-loop/lid; other site
220341003214	ABC transporter signature motif; other site
220341003215	Walker B; other site
220341003216	D-loop; other site
220341003217	H-loop/switch region; other site
220341003218	PS00017 ATP/GTP-binding site motif A (P-loop)
220341003219	PS00211 ABC transporters family signature
220341003220	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
220341003221	hypothetical protein; Provisional; Region: PRK11827
220341003222	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
220341003223	Ligand binding site; other site
220341003224	oligomer interface; other site
220341003225	hypothetical protein; Provisional; Region: PRK10593
220341003226	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
220341003227	putative active site [active]
220341003228	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
220341003229	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
220341003230	S-adenosylmethionine binding site [chemical binding]; other site
220341003231	PS00017 ATP/GTP-binding site motif A (P-loop)
220341003232	condesin subunit F; Provisional; Region: PRK05260
220341003233	condesin subunit E; Provisional; Region: PRK05256
220341003234	Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096
220341003235	P-loop containing region of AAA domain; Region: AAA_29; cl17516
220341003236	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
220341003237	PS00017 ATP/GTP-binding site motif A (P-loop)
220341003238	murein L,D-transpeptidase; Provisional; Region: PRK10594
220341003239	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
220341003240	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
220341003241	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
220341003242	Peptidase M15; Region: Peptidase_M15_3; cl01194
220341003243	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
220341003244	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
220341003245	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
220341003246	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341003247	homodimer interface [polypeptide binding]; other site
220341003248	catalytic residue [active]
220341003249	PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site
220341003250	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
220341003251	trimer interface [polypeptide binding]; other site
220341003252	eyelet of channel; other site
220341003253	PS00576 General diffusion Gram-negative porins signature
220341003254	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
220341003255	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
220341003256	putative dimer interface [polypeptide binding]; other site
220341003257	putative anticodon binding site; other site
220341003258	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
220341003259	homodimer interface [polypeptide binding]; other site
220341003260	motif 1; other site
220341003261	motif 2; other site
220341003262	active site
220341003263	motif 3; other site
220341003264	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2
220341003265	PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1
220341003266	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
220341003267	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
220341003268	putative DNA binding site [nucleotide binding]; other site
220341003269	putative Zn2+ binding site [ion binding]; other site
220341003270	AsnC family; Region: AsnC_trans_reg; pfam01037
220341003271	PS00519 Bacterial regulatory proteins, asnC family signature
220341003272	Pseudogene. Similar to Escherichia coli putative diaminopropionate ammonia-lyase YGEX SW:DPAL_ECOLI (Q46804) fasta scores: E(): 0, 51.3% id in 228 aa
220341003273	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
220341003274	PS00873 Sodium:alanine symporter family signature
220341003275	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
220341003276	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
220341003277	active site
220341003278	prophage 10: shares limited similarity with the S. typhimurium Gifsy-2 phage and is integrated at the analogous locus.
220341003279	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
220341003280	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
220341003281	Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659
220341003282	phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191
220341003283	Int/Topo IB signature motif; other site
220341003284	Putative excisionase (DUF1233); Region: DUF1233; pfam06806
220341003285	Protein of unknown function (DUF4060); Region: DUF4060; pfam13269
220341003286	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
220341003287	PS00092 N-6 Adenine-specific DNA methylases signature
220341003288	DGQHR domain; Region: DGQHR; TIGR03187
220341003289	YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588
220341003290	phage recombination protein Bet; Region: bet_lambda; TIGR01913
220341003291	Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064
220341003292	FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354
220341003293	transcriptional repressor DicA; Reviewed; Region: PRK09706
220341003294	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
220341003295	non-specific DNA binding site [nucleotide binding]; other site
220341003296	salt bridge; other site
220341003297	sequence-specific DNA binding site [nucleotide binding]; other site
220341003298	Bacteriophage CII protein; Region: Phage_CII; pfam05269
220341003299	Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492
220341003300	primosomal protein DnaI; Provisional; Region: PRK02854
220341003301	putative replication protein; Provisional; Region: PRK12377
220341003302	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
220341003303	Walker A motif; other site
220341003304	ATP binding site [chemical binding]; other site
220341003305	Walker B motif; other site
220341003306	arginine finger; other site
220341003307	Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163
220341003308	Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935
220341003309	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
220341003310	Methyltransferase domain; Region: Methyltransf_25; pfam13649
220341003311	Protein of unknown function (DUF550); Region: DUF550; pfam04447
220341003312	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
220341003313	DinI-like family; Region: DinI; pfam06183
220341003314	Protein of unknown function (DUF1367); Region: DUF1367; pfam07105
220341003315	Bacteriophage Lambda NinG protein; Region: NinG; pfam05766
220341003316	Antitermination protein; Region: Antiterm; pfam03589
220341003317	Antitermination protein; Region: Antiterm; pfam03589
220341003318	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341003319	Protein of unknown function (DUF754); Region: DUF754; pfam05449
220341003320	Predicted chitinase [General function prediction only]; Region: COG3179
220341003321	catalytic residue [active]
220341003322	Protein of unknown function (DUF2514); Region: DUF2514; pfam10721
220341003323	Phage terminase large subunit; Region: Terminase_3; cl12054
220341003324	Protein of unknown function (DUF1073); Region: DUF1073; pfam06381
220341003325	Condensin complex subunit 2; Region: Cnd2; cl19886
220341003326	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
220341003327	Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979
220341003328	Domain of unknown function (DUF336); Region: DUF336; cl01249
220341003329	Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950
220341003330	Protein of unknown function (DUF4054); Region: DUF4054; pfam13262
220341003331	Superfamily II helicase, archaea-specific [General function prediction only]; Region: COG1202
220341003332	Protein of unknown function (DUF3383); Region: DUF3383; pfam11863
220341003333	Protein of unknown function (DUF3277); Region: DUF3277; pfam11681
220341003334	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050
220341003335	Dynein heavy chain, N-terminal region 2; Region: DHC_N2; pfam08393
220341003336	virion protein; Provisional; Region: V; PHA02564
220341003337	HEPN domain; Region: HEPN; cl00824
220341003338	Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812
220341003339	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
220341003340	Baseplate J-like protein; Region: Baseplate_J; cl01294
220341003341	Protein of unknown function (DUF2612); Region: DUF2612; pfam11041
220341003342	long tail fiber, proximal subunit; Provisional; Region: 34; PHA02584
220341003343	Phage-related tail fibre protein [General function prediction only]; Region: COG5301
220341003344	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
220341003345	Protein of unknown function (DUF1076); Region: DUF1076; pfam06416
220341003346	DinI-like family; Region: DinI; cl11630
220341003347	aminopeptidase N; Provisional; Region: pepN; PRK14015
220341003348	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
220341003349	active site
220341003350	Zn binding site [ion binding]; other site
220341003351	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature
220341003352	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
220341003353	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
220341003354	quinone interaction residues [chemical binding]; other site
220341003355	active site
220341003356	catalytic residues [active]
220341003357	FMN binding site [chemical binding]; other site
220341003358	substrate binding site [chemical binding]; other site
220341003359	PS00911 Dihydroorotate dehydrogenase signature 1
220341003360	PS00912 Dihydroorotate dehydrogenase signature 2
220341003361	Protein of unknown function (DUF1379); Region: DUF1379; pfam07126
220341003362	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
220341003363	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
220341003364	MOSC domain; Region: MOSC; pfam03473
220341003365	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
220341003366	catalytic loop [active]
220341003367	iron binding site [ion binding]; other site
220341003368	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
220341003369	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
220341003370	Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170
220341003371	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
220341003372	S-adenosylmethionine binding site [chemical binding]; other site
220341003373	ABC transporter ATPase component; Reviewed; Region: PRK11147
220341003374	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
220341003375	ABC transporter; Region: ABC_tran_2; pfam12848
220341003376	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
220341003377	type III secretion system chaperone SseA; Provisional; Region: PRK15365
220341003378	PS00017 ATP/GTP-binding site motif A (P-loop)
220341003379	PS00211 ABC transporters family signature
220341003380	PS00017 ATP/GTP-binding site motif A (P-loop)
220341003381	PS00211 ABC transporters family signature
220341003382	paraquat-inducible membrane protein A; Provisional; Region: PRK15103
220341003383	Paraquat-inducible protein A; Region: PqiA; pfam04403
220341003384	Paraquat-inducible protein A; Region: PqiA; pfam04403
220341003385	paraquat-inducible protein B; Provisional; Region: PRK10807
220341003386	mce related protein; Region: MCE; pfam02470
220341003387	mce related protein; Region: MCE; pfam02470
220341003388	mce related protein; Region: MCE; pfam02470
220341003389	Biogenesis of lysosome-related organelles complex-1 subunit 2; Region: BLOC1_2; pfam10046
220341003390	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
220341003391	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341003392	ribosome modulation factor; Provisional; Region: PRK14563
220341003393	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
220341003394	active site 1 [active]
220341003395	dimer interface [polypeptide binding]; other site
220341003396	active site 2 [active]
220341003397	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
220341003398	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
220341003399	Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097
220341003400	outer membrane protein A; Reviewed; Region: PRK10808
220341003401	OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389
220341003402	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
220341003403	ligand binding site [chemical binding]; other site
220341003404	PS01068 OmpA-like domain
220341003405	cell division inhibitor SulA; Region: sula; TIGR00623
220341003406	Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070
220341003407	TfoX C-terminal domain; Region: TfoX_C; pfam04994
220341003408	TIGR01666 family membrane protein; Region: YCCS
220341003409	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
220341003410	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
220341003411	Predicted membrane protein [Function unknown]; Region: COG3304
220341003412	Domain of unknown function (DUF307); Region: DUF307; pfam03733
220341003413	Domain of unknown function (DUF307); Region: DUF307; pfam03733
220341003414	DNA helicase IV; Provisional; Region: helD; PRK11054
220341003415	DNA helicase IV / RNA helicase N terminal; Region: Helicase_IV_N; pfam12462
220341003416	Part of AAA domain; Region: AAA_19; pfam13245
220341003417	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
220341003418	PS00017 ATP/GTP-binding site motif A (P-loop)
220341003419	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
220341003420	active site
220341003421	dimer interfaces [polypeptide binding]; other site
220341003422	catalytic residues [active]
220341003423	PS01335 Methylglyoxal synthase active site
220341003424	hypothetical protein; Provisional; Region: PRK03641
220341003425	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
220341003426	heat shock protein HspQ; Provisional; Region: PRK14129
220341003427	23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128
220341003428	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
220341003429	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
220341003430	putative RNA binding site [nucleotide binding]; other site
220341003431	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
220341003432	S-adenosylmethionine binding site [chemical binding]; other site
220341003433	Transposase IS200 like; Region: Y1_Tnp; pfam01797
220341003434	PS00041 Bacterial regulatory proteins, araC family signature
220341003435	acylphosphatase; Provisional; Region: PRK14426
220341003436	PS00150 Acylphosphatase signature 1
220341003437	PS00151 Acylphosphatase signature 2
220341003438	sulfur transfer protein TusE; Provisional; Region: PRK11508
220341003439	YccA-like proteins; Region: YccA_like; cd10433
220341003440	PS01243 Uncharacterized protein family UPF0005 signature
220341003441	Salmonella Pathogenicity Island 5
220341003442	IS200
220341003443	Transposase IS200 like; Region: Y1_Tnp; pfam01797
220341003444	PipA protein; Region: PipA; pfam07108
220341003445	secreted effector protein PipB; Provisional; Region: PRK15197
220341003446	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
220341003447	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
220341003448	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
220341003449	type III secretion chaperone protein SigE; Provisional; Region: PRK15202
220341003450	Enterobacterial virulence protein IpgD; Region: IpgD; pfam05925
220341003451	Domain of unknown function (DUF3950); Region: DUF3950; pfam13132
220341003452	Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690
220341003453	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
220341003454	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
220341003455	dimerization interface [polypeptide binding]; other site
220341003456	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
220341003457	dimer interface [polypeptide binding]; other site
220341003458	phosphorylation site [posttranslational modification]
220341003459	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
220341003460	ATP binding site [chemical binding]; other site
220341003461	Mg2+ binding site [ion binding]; other site
220341003462	G-X-G motif; other site
220341003463	transcriptional regulatory protein YedW; Provisional; Region: PRK11517
220341003464	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
220341003465	active site
220341003466	phosphorylation site [posttranslational modification]
220341003467	intermolecular recognition site; other site
220341003468	dimerization interface [polypeptide binding]; other site
220341003469	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
220341003470	DNA binding site [nucleotide binding]
220341003471	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
220341003472	active site
220341003473	homotetramer interface [polypeptide binding]; other site
220341003474	4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486
220341003475	4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310
220341003476	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
220341003477	homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337
220341003478	Transcriptional regulators [Transcription]; Region: MarR; COG1846
220341003479	PS01117 Bacterial regulatory proteins, marR family signature
220341003480	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203
220341003481	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, N-terminal subunit; Region: HpaG-N-term; TIGR02305
220341003482	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
220341003483	Pseudogene. Similar to Escherichia coli 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase hpcC SW:HPCC_ECOLI (P42269) fasta scores: E(): 0, 96.2% id in 366 aa. This CDS contains a frameshift after codon 97. The sequence has been checked and is believed to be correct
220341003484	PS00687 Aldehyde dehydrogenases glutamic acid active site
220341003485	PS00070 Aldehyde dehydrogenases cysteine active site
220341003486	The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370
220341003487	putative active site [active]
220341003488	putative metal binding site [ion binding]; other site
220341003489	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
220341003490	putative substrate binding pocket [chemical binding]; other site
220341003491	trimer interface [polypeptide binding]; other site
220341003492	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
220341003493	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Region: HpaI; TIGR02311
220341003494	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
220341003495	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341003496	putative substrate translocation pore; other site
220341003497	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
220341003498	Cupin domain; Region: Cupin_2; pfam07883
220341003499	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341003500	PS00041 Bacterial regulatory proteins, araC family signature
220341003501	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
220341003502	chaperone-modulator protein CbpM; Provisional; Region: PRK10265
220341003503	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
220341003504	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
220341003505	HSP70 interaction site [polypeptide binding]; other site
220341003506	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
220341003507	substrate binding site [polypeptide binding]; other site
220341003508	dimer interface [polypeptide binding]; other site
220341003509	PS00636 Nt-dnaJ domain signature
220341003510	Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233
220341003511	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
220341003512	Sulfite exporter TauE/SafE; Region: TauE; cl19196
220341003513	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
220341003514	DsbD alpha interface [polypeptide binding]; other site
220341003515	catalytic residues [active]
220341003516	conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283
220341003517	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
220341003518	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
220341003519	catalytic residues [active]
220341003520	PS00194 Thioredoxin family active site
220341003521	TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011
220341003522	catalytic residues [active]
220341003523	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
220341003524	catalytic core [active]
220341003525	PS00616 Histidine acid phosphatases phosphohistidine signature
220341003526	PS00778 Histidine acid phosphatases active site signature
220341003527	hypothetical protein; Provisional; Region: PRK10174
220341003528	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
220341003529	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
220341003530	General stress protein [General function prediction only]; Region: GsiB; COG3729
220341003531	HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008
220341003532	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
220341003533	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
220341003534	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755
220341003535	trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809
220341003536	Predicted transcriptional regulator [Transcription]; Region: COG3905
220341003537	DNA-binding domain of Proline dehydrogenase; Region: Pro_dh-DNA_bdg; pfam14850
220341003538	Proline dehydrogenase; Region: Pro_dh; pfam01619
220341003539	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
220341003540	Glutamate binding site [chemical binding]; other site
220341003541	NAD binding site [chemical binding]; other site
220341003542	catalytic residues [active]
220341003543	PS00070 Aldehyde dehydrogenases cysteine active site
220341003544	PS00687 Aldehyde dehydrogenases glutamic acid active site
220341003545	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
220341003546	Na binding site [ion binding]; other site
220341003547	PS00456 Sodium:solute symporter family signature 1
220341003548	PS00457 Sodium:solute symporter family signature 2
220341003549	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
220341003550	hypothetical protein; Provisional; Region: PRK10536
220341003551	PS00017 ATP/GTP-binding site motif A (P-loop)
220341003552	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
220341003553	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
220341003554	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
220341003555	putative active site [active]
220341003556	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
220341003557	putative active site cavity [active]
220341003558	N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131
220341003559	Galactose oxidase, central domain; Region: Kelch_3; pfam13415
220341003560	Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178
220341003561	putative sialic acid transporter; Provisional; Region: PRK12307
220341003562	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341003563	putative substrate translocation pore; other site
220341003564	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
220341003565	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
220341003566	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
220341003567	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
220341003568	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
220341003569	putative ligand binding site [chemical binding]; other site
220341003570	NAD binding site [chemical binding]; other site
220341003571	dimerization interface [polypeptide binding]; other site
220341003572	catalytic site [active]
220341003573	putative hydrolase; Validated; Region: PRK09248
220341003574	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
220341003575	active site
220341003576	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
220341003577	Protein of unknown function (DUF1097); Region: DUF1097; pfam06496
220341003578	curli production assembly/transport protein CsgG; Provisional; Region: PRK15184
220341003579	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341003580	curli assembly protein CsgF; Provisional; Region: PRK10050
220341003581	curli assembly protein CsgE; Provisional; Region: PRK10386
220341003582	DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100
220341003583	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
220341003584	DNA binding residues [nucleotide binding]
220341003585	dimerization interface [polypeptide binding]; other site
220341003586	PS00622 Bacterial regulatory proteins, luxR family signature
220341003587	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
220341003588	Curlin associated repeat; Region: Curlin_rpt; pfam07012
220341003589	Curlin associated repeat; Region: Curlin_rpt; pfam07012
220341003590	major curlin subunit; Provisional; Region: csgA; PRK10051
220341003591	curli assembly protein CsgC; Provisional; Region: csgC; PRK10102
220341003592	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
220341003593	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
220341003594	putative ADP-ribose binding site [chemical binding]; other site
220341003595	putative active site [active]
220341003596	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
220341003597	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
220341003598	putative active site [active]
220341003599	catalytic site [active]
220341003600	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
220341003601	putative active site [active]
220341003602	catalytic site [active]
220341003603	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
220341003604	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
220341003605	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
220341003606	Ligand binding site; other site
220341003607	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
220341003608	DXD motif; other site
220341003609	lipoprotein; Provisional; Region: PRK10175
220341003610	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341003611	secY/secA suppressor protein; Provisional; Region: PRK11467
220341003612	drug efflux system protein MdtG; Provisional; Region: PRK09874
220341003613	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341003614	putative substrate translocation pore; other site
220341003615	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
220341003616	putative acyl-acceptor binding pocket; other site
220341003617	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
220341003618	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
220341003619	active site residue [active]
220341003620	PS00017 ATP/GTP-binding site motif A (P-loop)
220341003621	hypothetical protein; Provisional; Region: PRK03757
220341003622	Protein of unknown function (DUF2770); Region: DUF2770; pfam10968
220341003623	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
220341003624	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
220341003625	biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301
220341003626	DNA damage-inducible protein I; Provisional; Region: PRK10597
220341003627	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341003628	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
220341003629	active site
220341003630	substrate binding pocket [chemical binding]; other site
220341003631	dimer interface [polypeptide binding]; other site
220341003632	PS00483 Dihydroorotase signature 2
220341003633	PS00482 Dihydroorotase signature 1
220341003634	lipoprotein; Provisional; Region: PRK10598
220341003635	glutaredoxin 2; Provisional; Region: PRK10387
220341003636	GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037
220341003637	C-terminal domain interface [polypeptide binding]; other site
220341003638	GSH binding site (G-site) [chemical binding]; other site
220341003639	catalytic residues [active]
220341003640	putative dimer interface [polypeptide binding]; other site
220341003641	C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199
220341003642	N-terminal domain interface [polypeptide binding]; other site
220341003643	PS00195 Glutaredoxin active site
220341003644	multidrug resistance protein MdtH; Provisional; Region: PRK11646
220341003645	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341003646	putative substrate translocation pore; other site
220341003647	ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809
220341003648	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
220341003649	hypothetical protein; Provisional; Region: PRK11239
220341003650	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
220341003651	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
220341003652	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
220341003653	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
220341003654	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
220341003655	flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459
220341003656	anti-sigma28 factor FlgM; Provisional; Region: PRK10810
220341003657	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
220341003658	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
220341003659	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
220341003660	flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173
220341003661	PS00588 Flagella basal body rod proteins signature
220341003662	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
220341003663	flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173
220341003664	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
220341003665	PS00588 Flagella basal body rod proteins signature
220341003666	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
220341003667	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
220341003668	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
220341003669	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
220341003670	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
220341003671	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
220341003672	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
220341003673	PS00588 Flagella basal body rod proteins signature
220341003674	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787
220341003675	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
220341003676	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
220341003677	PS00588 Flagella basal body rod proteins signature
220341003678	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12694
220341003679	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
220341003680	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
220341003681	PS00588 Flagella basal body rod proteins signature
220341003682	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
220341003683	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
220341003684	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
220341003685	Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951
220341003686	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
220341003687	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147
220341003688	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
220341003689	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
220341003690	PS00588 Flagella basal body rod proteins signature
220341003691	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027
220341003692	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
220341003693	IS200
220341003694	Transposase IS200 like; Region: Y1_Tnp; pfam01797
220341003695	ribonuclease E; Reviewed; Region: rne; PRK10811
220341003696	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
220341003697	homodimer interface [polypeptide binding]; other site
220341003698	oligonucleotide binding site [chemical binding]; other site
220341003699	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
220341003700	Protein of unknown function (DUF3157); Region: DUF3157; pfam11355
220341003701	Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111
220341003702	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
220341003703	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
220341003704	RNA binding surface [nucleotide binding]; other site
220341003705	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
220341003706	active site
220341003707	PS01129 Rlu family of pseudouridine synthase signature
220341003708	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
220341003709	active site
220341003710	dimer interface [polypeptide binding]; other site
220341003711	hypothetical protein; Provisional; Region: PRK11193
220341003712	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
220341003713	putative phosphate acyltransferase; Provisional; Region: PRK05331
220341003714	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
220341003715	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
220341003716	dimer interface [polypeptide binding]; other site
220341003717	active site
220341003718	CoA binding pocket [chemical binding]; other site
220341003719	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
220341003720	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
220341003721	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
220341003722	NAD(P) binding site [chemical binding]; other site
220341003723	homotetramer interface [polypeptide binding]; other site
220341003724	homodimer interface [polypeptide binding]; other site
220341003725	active site
220341003726	PS00061 Short-chain dehydrogenases/reductases family signature
220341003727	acyl carrier protein; Provisional; Region: acpP; PRK00982
220341003728	PS00012 Phosphopantetheine attachment site
220341003729	PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature
220341003730	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
220341003731	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
220341003732	dimer interface [polypeptide binding]; other site
220341003733	active site
220341003734	PS00606 Beta-ketoacyl synthases active site
220341003735	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
220341003736	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341003737	catalytic residue [active]
220341003738	PS00770 Aminotransferases class-IV signature
220341003739	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
220341003740	dimerization interface [polypeptide binding]; other site
220341003741	thymidylate kinase; Validated; Region: tmk; PRK00698
220341003742	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
220341003743	TMP-binding site; other site
220341003744	ATP-binding site [chemical binding]; other site
220341003745	PS01331 Thymidylate kinase signature
220341003746	DNA polymerase III subunit delta'; Validated; Region: PRK07993
220341003747	DNA polymerase III subunit delta'; Validated; Region: PRK08485
220341003748	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
220341003749	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
220341003750	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
220341003751	active site
220341003752	PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089
220341003753	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
220341003754	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
220341003755	active site turn [active]
220341003756	phosphorylation site [posttranslational modification]
220341003757	PS01035 PTS EIIB domains cysteine phosphorylation site signature
220341003758	PS01156 TonB-dependent receptor proteins signature 2
220341003759	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
220341003760	nucleotide binding site/active site [active]
220341003761	HIT family signature motif; other site
220341003762	catalytic residue [active]
220341003763	PS00892 HIT family signature
220341003764	Putative periplasmic lipoprotein; Region: DUF1425; cd09030
220341003765	putative dimer interface [polypeptide binding]; other site
220341003766	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341003767	Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417
220341003768	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341003769	Phosphotransferase enzyme family; Region: APH; pfam01636
220341003770	thiamine kinase; Provisional; Region: thiK; PRK10271
220341003771	substrate binding site [chemical binding]; other site
220341003772	beta-hexosaminidase; Provisional; Region: PRK05337
220341003773	PS00775 Glycosyl hydrolases family 3 active site
220341003774	hypothetical protein; Provisional; Region: PRK04940
220341003775	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
220341003776	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
220341003777	hypothetical protein; Provisional; Region: PRK11280
220341003778	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
220341003779	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
220341003780	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
220341003781	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
220341003782	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
220341003783	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
220341003784	transcription-repair coupling factor; Provisional; Region: PRK10689
220341003785	Bifunctional transglycosylase second domain; Region: UB2H; pfam14814
220341003786	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
220341003787	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
220341003788	ATP binding site [chemical binding]; other site
220341003789	putative Mg++ binding site [ion binding]; other site
220341003790	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
220341003791	nucleotide binding region [chemical binding]; other site
220341003792	ATP-binding site [chemical binding]; other site
220341003793	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
220341003794	PS00017 ATP/GTP-binding site motif A (P-loop)
220341003795	outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814
220341003796	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
220341003797	FtsX-like permease family; Region: FtsX; pfam02687
220341003798	lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629
220341003799	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
220341003800	Walker A/P-loop; other site
220341003801	ATP binding site [chemical binding]; other site
220341003802	Q-loop/lid; other site
220341003803	ABC transporter signature motif; other site
220341003804	Walker B; other site
220341003805	D-loop; other site
220341003806	H-loop/switch region; other site
220341003807	PS00017 ATP/GTP-binding site motif A (P-loop)
220341003808	PS00211 ABC transporters family signature
220341003809	outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146
220341003810	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
220341003811	FtsX-like permease family; Region: FtsX; pfam02687
220341003812	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
220341003813	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
220341003814	nucleotide binding site [chemical binding]; other site
220341003815	PS00017 ATP/GTP-binding site motif A (P-loop)
220341003816	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
220341003817	NAD+ binding site [chemical binding]; other site
220341003818	substrate binding site [chemical binding]; other site
220341003819	Zn binding site [ion binding]; other site
220341003820	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
220341003821	spermidine/putrescine ABC transporter membrane protein; Reviewed; Region: potC; PRK09500
220341003822	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341003823	dimer interface [polypeptide binding]; other site
220341003824	conserved gate region; other site
220341003825	putative PBP binding loops; other site
220341003826	ABC-ATPase subunit interface; other site
220341003827	PS00402 Binding-protein-dependent transport systems inner membrane comp sign.
220341003828	secreted effector protein SifA; Reviewed; Region: sifA; PRK09498
220341003829	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
220341003830	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341003831	dimer interface [polypeptide binding]; other site
220341003832	conserved gate region; other site
220341003833	putative PBP binding loops; other site
220341003834	ABC-ATPase subunit interface; other site
220341003835	PS00402 Binding-protein-dependent transport systems inner membrane comp sign.
220341003836	putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452
220341003837	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
220341003838	Walker A/P-loop; other site
220341003839	ATP binding site [chemical binding]; other site
220341003840	Q-loop/lid; other site
220341003841	ABC transporter signature motif; other site
220341003842	Walker B; other site
220341003843	D-loop; other site
220341003844	H-loop/switch region; other site
220341003845	TOBE domain; Region: TOBE_2; pfam08402
220341003846	PS00211 ABC transporters family signature
220341003847	PS00017 ATP/GTP-binding site motif A (P-loop)
220341003848	peptidase T-like protein; Region: PepT-like; TIGR01883
220341003849	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
220341003850	metal binding site [ion binding]; metal-binding site
220341003851	dimer interface [polypeptide binding]; other site
220341003852	PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1
220341003853	PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2
220341003854	Tetratricopeptide repeat; Region: TPR_12; pfam13424
220341003855	Tetratricopeptide repeat; Region: TPR_12; pfam13424
220341003856	Uncharacterized conserved protein [Function unknown]; Region: COG2850
220341003857	sensor protein PhoQ; Provisional; Region: PRK10815
220341003858	PhoQ Sensor; Region: PhoQ_Sensor; pfam08918
220341003859	HAMP domain; Region: HAMP; pfam00672
220341003860	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
220341003861	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
220341003862	ATP binding site [chemical binding]; other site
220341003863	Mg2+ binding site [ion binding]; other site
220341003864	G-X-G motif; other site
220341003865	DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816
220341003866	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
220341003867	active site
220341003868	phosphorylation site [posttranslational modification]
220341003869	intermolecular recognition site; other site
220341003870	dimerization interface [polypeptide binding]; other site
220341003871	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
220341003872	DNA binding site [nucleotide binding]
220341003873	adenylosuccinate lyase; Provisional; Region: PRK09285
220341003874	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
220341003875	tetramer interface [polypeptide binding]; other site
220341003876	active site
220341003877	PS00163 Fumarate lyases signature
220341003878	putative lysogenization regulator; Reviewed; Region: PRK00218
220341003879	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420
220341003880	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
220341003881	Ligand Binding Site [chemical binding]; other site
220341003882	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
220341003883	nudix motif; other site
220341003884	PS00893 mutT domain signature
220341003885	Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461
220341003886	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
220341003887	23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394
220341003888	Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566
220341003889	probable active site [active]
220341003890	PS01149 Rsu family of pseudouridine synthase signature
220341003891	isocitrate dehydrogenase; Reviewed; Region: PRK07006
220341003892	PS00470 Isocitrate and isopropylmalate dehydrogenases signature
220341003893	IS200
220341003894	Transposase IS200 like; Region: Y1_Tnp; pfam01797
220341003895	calcium/sodium:proton antiporter; Provisional; Region: PRK10599
220341003896	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
220341003897	cation transport regulator; Reviewed; Region: chaB; PRK09582
220341003898	Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553
220341003899	putative invasin; Provisional; Region: PRK10177
220341003900	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
220341003901	transcriptional regulator NarL; Provisional; Region: PRK10651
220341003902	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
220341003903	active site
220341003904	phosphorylation site [posttranslational modification]
220341003905	intermolecular recognition site; other site
220341003906	dimerization interface [polypeptide binding]; other site
220341003907	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
220341003908	DNA binding residues [nucleotide binding]
220341003909	dimerization interface [polypeptide binding]; other site
220341003910	PS00622 Bacterial regulatory proteins, luxR family signature
220341003911	nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600
220341003912	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
220341003913	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
220341003914	dimerization interface [polypeptide binding]; other site
220341003915	Histidine kinase; Region: HisKA_3; pfam07730
220341003916	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
220341003917	ATP binding site [chemical binding]; other site
220341003918	Mg2+ binding site [ion binding]; other site
220341003919	G-X-G motif; other site
220341003920	lysophospholipid transporter LplT; Provisional; Region: PRK11195; cl19150
220341003921	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
220341003922	respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580
220341003923	Respiratory nitrate reductase alpha N-terminal; Region: Nitr_red_alph_N; pfam14710
220341003924	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
220341003925	[4Fe-4S] binding site [ion binding]; other site
220341003926	molybdopterin cofactor binding site [chemical binding]; other site
220341003927	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
220341003928	molybdopterin cofactor binding site; other site
220341003929	PS00551 Prokaryotic molybdopterin oxidoreductases signature 1
220341003930	PS00490 Prokaryotic molybdopterin oxidoreductases signature 2
220341003931	PS00932 Prokaryotic molybdopterin oxidoreductases signature 3
220341003932	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
220341003933	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
220341003934	Respiratory nitrate reductase beta C-terminal; Region: Nitr_red_bet_C; pfam14711
220341003935	PS00190 Cytochrome c family heme-binding site signature
220341003936	PS00190 Cytochrome c family heme-binding site signature
220341003937	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
220341003938	respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351
220341003939	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
220341003940	Sel1-like repeats; Region: SEL1; smart00671
220341003941	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
220341003942	Sel1-like repeats; Region: SEL1; smart00671
220341003943	Sel1-like repeats; Region: SEL1; smart00671
220341003944	Sel1-like repeats; Region: SEL1; smart00671
220341003945	Sel1-like repeats; Region: SEL1; smart00671
220341003946	Sel1-like repeats; Region: SEL1; smart00671
220341003947	Sel1-like repeats; Region: SEL1; smart00671
220341003948	Sel1-like repeats; Region: SEL1; smart00671
220341003949	Sel1-like repeats; Region: SEL1; smart00671
220341003950	Sel1-like repeats; Region: SEL1; smart00671
220341003951	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
220341003952	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
220341003953	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
220341003954	putative active site [active]
220341003955	putative substrate binding site [chemical binding]; other site
220341003956	putative cosubstrate binding site; other site
220341003957	catalytic site [active]
220341003958	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
220341003959	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
220341003960	active site
220341003961	nucleophile elbow; other site
220341003962	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
220341003963	active site
220341003964	response regulator of RpoS; Provisional; Region: PRK10693
220341003965	phosphorylation site [posttranslational modification]
220341003966	intermolecular recognition site; other site
220341003967	dimerization interface [polypeptide binding]; other site
220341003968	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
220341003969	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
220341003970	active site
220341003971	tetramer interface; other site
220341003972	global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947
220341003973	DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916
220341003974	thymidine kinase; Provisional; Region: PRK04296
220341003975	PS00603 Thymidine kinase cellular-type signature
220341003976	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
220341003977	Coenzyme A acylating aldehyde dehydrogenase (ACDH), Ethanolamine utilization protein EutE, and related proteins; Region: ALDH_F20_ACDH_EutE-like; cd07081
220341003978	putative catalytic cysteine [active]
220341003979	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
220341003980	putative active site [active]
220341003981	metal binding site [ion binding]; metal-binding site
220341003982	PS00060 Iron-containing alcohol dehydrogenases signature 2
220341003983	PS00913 Iron-containing alcohol dehydrogenases signature 1
220341003984	hypothetical protein; Provisional; Region: PRK11111
220341003985	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
220341003986	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
220341003987	peptide binding site [polypeptide binding]; other site
220341003988	PS01040 Bacterial extracellular solute-binding proteins
220341003989	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
220341003990	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341003991	dimer interface [polypeptide binding]; other site
220341003992	conserved gate region; other site
220341003993	putative PBP binding loops; other site
220341003994	ABC-ATPase subunit interface; other site
220341003995	PS00402 Binding-protein-dependent transport systems inner membrane comp sign.
220341003996	PS00402 Binding-protein-dependent transport systems inner membrane comp sign.
220341003997	oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473
220341003998	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
220341003999	Walker A/P-loop; other site
220341004000	ATP binding site [chemical binding]; other site
220341004001	Q-loop/lid; other site
220341004002	ABC transporter signature motif; other site
220341004003	Walker B; other site
220341004004	D-loop; other site
220341004005	H-loop/switch region; other site
220341004006	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
220341004007	PS00017 ATP/GTP-binding site motif A (P-loop)
220341004008	PS00211 ABC transporters family signature
220341004009	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
220341004010	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
220341004011	Walker A/P-loop; other site
220341004012	ATP binding site [chemical binding]; other site
220341004013	Q-loop/lid; other site
220341004014	ABC transporter signature motif; other site
220341004015	Walker B; other site
220341004016	D-loop; other site
220341004017	H-loop/switch region; other site
220341004018	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
220341004019	PS00017 ATP/GTP-binding site motif A (P-loop)
220341004020	PS00211 ABC transporters family signature
220341004021	Ion transport protein; Region: Ion_trans; pfam00520
220341004022	Ion channel; Region: Ion_trans_2; pfam07885
220341004023	Double zinc ribbon; Region: DZR; pfam12773
220341004024	dsDNA-mimic protein; Reviewed; Region: PRK05094
220341004025	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
220341004026	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
220341004027	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
220341004028	putative active site [active]
220341004029	catalytic site [active]
220341004030	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
220341004031	putative active site [active]
220341004032	catalytic site [active]
220341004033	YciI-like protein; Reviewed; Region: PRK11370
220341004034	transport protein TonB; Provisional; Region: PRK10819
220341004035	Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544
220341004036	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
220341004037	intracellular septation protein A; Reviewed; Region: PRK00259
220341004038	hypothetical protein; Provisional; Region: PRK02868
220341004039	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
220341004040	outer membrane protein W; Provisional; Region: PRK10959
220341004041	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
220341004042	dimanganese center [ion binding]; other site
220341004043	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
220341004044	dinuclear metal binding motif [ion binding]; other site
220341004045	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
220341004046	dimerization interface [polypeptide binding]; other site
220341004047	metal binding site [ion binding]; metal-binding site
220341004048	General stress protein [General function prediction only]; Region: GsiB; COG3729
220341004049	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
220341004050	substrate binding site [chemical binding]; other site
220341004051	active site
220341004052	catalytic residues [active]
220341004053	heterodimer interface [polypeptide binding]; other site
220341004054	PS00167 Tryptophan synthase alpha chain signature
220341004055	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
220341004056	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341004057	catalytic residue [active]
220341004058	PS00168 Tryptophan synthase beta chain pyridoxal-phosphate attachment site
220341004059	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
220341004060	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
220341004061	active site
220341004062	ribulose/triose binding site [chemical binding]; other site
220341004063	phosphate binding site [ion binding]; other site
220341004064	substrate (anthranilate) binding pocket [chemical binding]; other site
220341004065	product (indole) binding pocket [chemical binding]; other site
220341004066	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
220341004067	active site
220341004068	bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522
220341004069	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
220341004070	glutamine binding [chemical binding]; other site
220341004071	catalytic triad [active]
220341004072	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
220341004073	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
220341004074	PS00442 Glutamine amidotransferases class-I active site
220341004075	anthranilate synthase component I; Provisional; Region: PRK13564
220341004076	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
220341004077	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
220341004078	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
220341004079	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
220341004080	active site
220341004081	hypothetical protein; Provisional; Region: PRK11630
220341004082	PS01147 SUA5/yciO/yrdC family signature
220341004083	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
220341004084	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
220341004085	RNA binding surface [nucleotide binding]; other site
220341004086	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
220341004087	probable active site [active]
220341004088	PS01149 Rsu family of pseudouridine synthase signature
220341004089	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
220341004090	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
220341004091	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
220341004092	homodimer interface [polypeptide binding]; other site
220341004093	Walker A motif; other site
220341004094	ATP binding site [chemical binding]; other site
220341004095	hydroxycobalamin binding site [chemical binding]; other site
220341004096	Walker B motif; other site
220341004097	Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340
220341004098	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
220341004099	NADP binding site [chemical binding]; other site
220341004100	homodimer interface [polypeptide binding]; other site
220341004101	active site
220341004102	PS00061 Short-chain dehydrogenases/reductases family signature
220341004103	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
220341004104	putative inner membrane peptidase; Provisional; Region: PRK11778
220341004105	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
220341004106	tandem repeat interface [polypeptide binding]; other site
220341004107	oligomer interface [polypeptide binding]; other site
220341004108	active site residues [active]
220341004109	hypothetical protein; Provisional; Region: PRK11037
220341004110	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
220341004111	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
220341004112	active site
220341004113	interdomain interaction site; other site
220341004114	putative metal-binding site [ion binding]; other site
220341004115	nucleotide binding site [chemical binding]; other site
220341004116	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
220341004117	domain I; other site
220341004118	DNA binding groove [nucleotide binding]
220341004119	phosphate binding site [ion binding]; other site
220341004120	domain II; other site
220341004121	domain III; other site
220341004122	nucleotide binding site [chemical binding]; other site
220341004123	catalytic site [active]
220341004124	domain IV; other site
220341004125	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
220341004126	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
220341004127	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
220341004128	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
220341004129	PS00396 Prokaryotic DNA topoisomerase I active site
220341004130	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
220341004131	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341004132	The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443
220341004133	substrate binding site [chemical binding]; other site
220341004134	putative dimerization interface [polypeptide binding]; other site
220341004135	PS00044 Bacterial regulatory proteins, lysR family signature
220341004136	aconitate hydratase; Validated; Region: PRK09277
220341004137	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
220341004138	substrate binding site [chemical binding]; other site
220341004139	ligand binding site [chemical binding]; other site
220341004140	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
220341004141	substrate binding site [chemical binding]; other site
220341004142	PS00450 Aconitase family signature 1
220341004143	PS01244 Aconitase family signature 2
220341004144	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
220341004145	dimerization interface [polypeptide binding]; other site
220341004146	active site
220341004147	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
220341004148	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
220341004149	active site
220341004150	Predicted membrane protein [Function unknown]; Region: COG3771
220341004151	Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956
220341004152	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
220341004153	TPR motif; other site
220341004154	binding surface
220341004155	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
220341004156	binding surface
220341004157	TPR motif; other site
220341004158	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
220341004159	active site
220341004160	dimer interface [polypeptide binding]; other site
220341004161	PS00156 Orotidine 5'-phosphate decarboxylase active site
220341004162	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
220341004163	putative rRNA binding site [nucleotide binding]; other site
220341004164	PS01118 Translation initiation factor SUI1 signature
220341004165	lipoprotein; Provisional; Region: PRK10540
220341004166	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
220341004167	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
220341004168	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
220341004169	RNase II stability modulator; Provisional; Region: PRK10060
220341004170	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
220341004171	putative active site [active]
220341004172	heme pocket [chemical binding]; other site
220341004173	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
220341004174	metal binding site [ion binding]; metal-binding site
220341004175	active site
220341004176	I-site; other site
220341004177	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
220341004178	exoribonuclease II; Provisional; Region: PRK05054
220341004179	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
220341004180	RNB domain; Region: RNB; pfam00773
220341004181	S1 RNA binding domain; Region: S1; pfam00575
220341004182	PS01175 Ribonuclease II family signature
220341004183	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
220341004184	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
220341004185	NAD binding site [chemical binding]; other site
220341004186	homotetramer interface [polypeptide binding]; other site
220341004187	homodimer interface [polypeptide binding]; other site
220341004188	substrate binding site [chemical binding]; other site
220341004189	active site
220341004190	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
220341004191	antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112
220341004192	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
220341004193	Walker A/P-loop; other site
220341004194	ATP binding site [chemical binding]; other site
220341004195	Q-loop/lid; other site
220341004196	ABC transporter signature motif; other site
220341004197	Walker B; other site
220341004198	D-loop; other site
220341004199	H-loop/switch region; other site
220341004200	PS00211 ABC transporters family signature
220341004201	PS00017 ATP/GTP-binding site motif A (P-loop)
220341004202	antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093
220341004203	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
220341004204	Walker A/P-loop; other site
220341004205	ATP binding site [chemical binding]; other site
220341004206	Q-loop/lid; other site
220341004207	ABC transporter signature motif; other site
220341004208	Walker B; other site
220341004209	D-loop; other site
220341004210	H-loop/switch region; other site
220341004211	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
220341004212	PS00017 ATP/GTP-binding site motif A (P-loop)
220341004213	antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111
220341004214	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
220341004215	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341004216	dimer interface [polypeptide binding]; other site
220341004217	conserved gate region; other site
220341004218	putative PBP binding loops; other site
220341004219	ABC-ATPase subunit interface; other site
220341004220	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapB; COG4168
220341004221	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341004222	dimer interface [polypeptide binding]; other site
220341004223	conserved gate region; other site
220341004224	putative PBP binding loops; other site
220341004225	ABC-ATPase subunit interface; other site
220341004226	antimicrobial peptide ABC transporter periplasmic binding protein SapA; Provisional; Region: PRK15109
220341004227	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
220341004228	peptide binding site [polypeptide binding]; other site
220341004229	PS01040 Bacterial extracellular solute-binding proteins
220341004230	phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608
220341004231	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
220341004232	Walker A motif; other site
220341004233	ATP binding site [chemical binding]; other site
220341004234	Walker B motif; other site
220341004235	arginine finger; other site
220341004236	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
220341004237	PS00688 Sigma-54 interaction domain C-terminal part signature
220341004238	PS00676 Sigma-54 interaction domain ATP-binding region B signature
220341004239	phage shock protein PspA; Provisional; Region: PRK10698
220341004240	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
220341004241	phage shock protein B; Provisional; Region: pspB; PRK09458
220341004242	DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697
220341004243	phage shock protein C; Region: phageshock_pspC; TIGR02978
220341004244	peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497
220341004245	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
220341004246	active site residue [active]
220341004247	PS00017 ATP/GTP-binding site motif A (P-loop)
220341004248	Predicted ATPase [General function prediction only]; Region: COG3106
220341004249	PS00017 ATP/GTP-binding site motif A (P-loop)
220341004250	hypothetical protein; Provisional; Region: PRK05415
220341004251	Predicted membrane protein [Function unknown]; Region: COG3768
220341004252	DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820
220341004253	N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877
220341004254	putative aromatic amino acid binding site; other site
220341004255	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
220341004256	putative active site [active]
220341004257	heme pocket [chemical binding]; other site
220341004258	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
220341004259	Walker A motif; other site
220341004260	ATP binding site [chemical binding]; other site
220341004261	Walker B motif; other site
220341004262	arginine finger; other site
220341004263	PS00675 Sigma-54 interaction domain ATP-binding region A signature
220341004264	PS00676 Sigma-54 interaction domain ATP-binding region B signature
220341004265	PS00688 Sigma-54 interaction domain C-terminal part signature
220341004266	IS200
220341004267	Transposase IS200 like; Region: Y1_Tnp; pfam01797
220341004268	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
220341004269	dimer interface [polypeptide binding]; other site
220341004270	catalytic triad [active]
220341004271	peroxidatic and resolving cysteines [active]
220341004272	PS01265 Tpx family signature
220341004273	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
220341004274	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
220341004275	active site
220341004276	PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1
220341004277	PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2
220341004278	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
220341004279	Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904
220341004280	putative active site [active]
220341004281	Zn binding site [ion binding]; other site
220341004282	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
220341004283	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
220341004284	peptide binding site [polypeptide binding]; other site
220341004285	phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259
220341004286	NAD(P) binding site [chemical binding]; other site
220341004287	active site lysine
220341004288	Transcriptional regulator [Transcription]; Region: LysR; COG0583
220341004289	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341004290	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
220341004291	putative effector binding pocket; other site
220341004292	putative dimerization interface [polypeptide binding]; other site
220341004293	PS00044 Bacterial regulatory proteins, lysR family signature
220341004294	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
220341004295	active site
220341004296	catalytic tetrad [active]
220341004297	PS00798 Aldo/keto reductase family signature 1
220341004298	PS00062 Aldo/keto reductase family signature 2
220341004299	PS00063 Aldo/keto reductase family putative active site signature
220341004300	oxidoreductase; Provisional; Region: PRK12742
220341004301	classical (c) SDRs; Region: SDR_c; cd05233
220341004302	NAD(P) binding site [chemical binding]; other site
220341004303	active site
220341004304	PS00061 Short-chain dehydrogenases/reductases family signature
220341004305	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
220341004306	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
220341004307	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
220341004308	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341004309	right oriC-binding transcriptional activator; Provisional; Region: PRK15121
220341004310	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341004311	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
220341004312	PS00041 Bacterial regulatory proteins, araC family signature
220341004313	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
220341004314	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: Tpx; COG2077
220341004315	Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382
220341004316	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
220341004317	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
220341004318	non-specific DNA binding site [nucleotide binding]; other site
220341004319	salt bridge; other site
220341004320	sequence-specific DNA binding site [nucleotide binding]; other site
220341004321	Cupin domain; Region: Cupin_2; pfam07883
220341004322	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
220341004323	Mechanosensitive ion channel; Region: MS_channel; pfam00924
220341004324	Protein of unknown function (DUF2534); Region: DUF2534; pfam10749
220341004325	universal stress protein UspE; Provisional; Region: PRK11175
220341004326	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
220341004327	Ligand Binding Site [chemical binding]; other site
220341004328	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
220341004329	Ligand Binding Site [chemical binding]; other site
220341004330	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
220341004331	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
220341004332	ligand binding site [chemical binding]; other site
220341004333	flexible hinge region; other site
220341004334	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
220341004335	putative switch regulator; other site
220341004336	non-specific DNA interactions [nucleotide binding]; other site
220341004337	DNA binding site [nucleotide binding]
220341004338	sequence specific DNA binding site [nucleotide binding]; other site
220341004339	putative cAMP binding site [chemical binding]; other site
220341004340	PS00042 Bacterial regulatory proteins, crp family signature
220341004341	O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286
220341004342	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
220341004343	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
220341004344	DNA binding site [nucleotide binding]
220341004345	active site
220341004346	PS00374 Methylated-DNA--protein-cysteine methyltransferase active site
220341004347	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
220341004348	Smr domain; Region: Smr; pfam01713
220341004349	HAMP domain; Region: HAMP; pfam00672
220341004350	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
220341004351	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
220341004352	dimer interface [polypeptide binding]; other site
220341004353	putative CheW interface [polypeptide binding]; other site
220341004354	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
220341004355	Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833
220341004356	Cl binding site [ion binding]; other site
220341004357	oligomer interface [polypeptide binding]; other site
220341004358	PS00017 ATP/GTP-binding site motif A (P-loop)
220341004359	PS00039 DEAD-box subfamily ATP-dependent helicases signature
220341004360	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
220341004361	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
220341004362	Ligand Binding Site [chemical binding]; other site
220341004363	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
220341004364	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
220341004365	Ligand Binding Site [chemical binding]; other site
220341004366	IS200
220341004367	Transposase IS200 like; Region: Y1_Tnp; pfam01797
220341004368	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
220341004369	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
220341004370	dimer interface [polypeptide binding]; other site
220341004371	PYR/PP interface [polypeptide binding]; other site
220341004372	TPP binding site [chemical binding]; other site
220341004373	substrate binding site [chemical binding]; other site
220341004374	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
220341004375	Domain of unknown function; Region: EKR; pfam10371
220341004376	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
220341004377	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
220341004378	TPP-binding site [chemical binding]; other site
220341004379	dimer interface [polypeptide binding]; other site
220341004380	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341004381	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341004382	PS00024 Hemopexin domain signature
220341004383	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
220341004384	heat-inducible protein; Provisional; Region: PRK10449
220341004385	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
220341004386	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
220341004387	putative ligand binding site [chemical binding]; other site
220341004388	putative NAD binding site [chemical binding]; other site
220341004389	catalytic site [active]
220341004390	PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3
220341004391	PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2
220341004392	PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature
220341004393	PS00017 ATP/GTP-binding site motif A (P-loop)
220341004394	hypothetical protein; Provisional; Region: PRK10695
220341004395	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
220341004396	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341004397	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784
220341004398	Uncharacterized conserved protein [Function unknown]; Region: COG3791
220341004399	azoreductase; Reviewed; Region: PRK00170
220341004400	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
220341004401	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
220341004402	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
220341004403	ATP binding site [chemical binding]; other site
220341004404	putative Mg++ binding site [ion binding]; other site
220341004405	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
220341004406	nucleotide binding region [chemical binding]; other site
220341004407	ATP-binding site [chemical binding]; other site
220341004408	Helicase associated domain (HA2); Region: HA2; pfam04408
220341004409	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
220341004410	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
220341004411	PS00017 ATP/GTP-binding site motif A (P-loop)
220341004412	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
220341004413	putative active site [active]
220341004414	Predicted membrane protein [Function unknown]; Region: COG5305
220341004415	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
220341004416	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341004417	dimer interface [polypeptide binding]; other site
220341004418	conserved gate region; other site
220341004419	putative PBP binding loops; other site
220341004420	ABC-ATPase subunit interface; other site
220341004421	PS00402 Binding-protein-dependent transport systems inner membrane comp sign.
220341004422	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
220341004423	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
220341004424	Walker A/P-loop; other site
220341004425	ATP binding site [chemical binding]; other site
220341004426	Q-loop/lid; other site
220341004427	ABC transporter signature motif; other site
220341004428	Walker B; other site
220341004429	D-loop; other site
220341004430	H-loop/switch region; other site
220341004431	PS00211 ABC transporters family signature
220341004432	PS00017 ATP/GTP-binding site motif A (P-loop)
220341004433	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
220341004434	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341004435	dimer interface [polypeptide binding]; other site
220341004436	conserved gate region; other site
220341004437	putative PBP binding loops; other site
220341004438	ABC-ATPase subunit interface; other site
220341004439	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
220341004440	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
220341004441	substrate binding pocket [chemical binding]; other site
220341004442	membrane-bound complex binding site; other site
220341004443	hinge residues; other site
220341004444	Predicted membrane protein [Function unknown]; Region: COG3326
220341004445	' Fasta hit to P76097 (447 aa), 87% identity in 366 aa overlap. Extreme N-terminus is deleted relative to S. typhimurium and E. coli'
220341004446	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
220341004447	substrate binding pocket [chemical binding]; other site
220341004448	catalytic triad [active]
220341004449	PS00941 Carboxylesterases type-B signature 2
220341004450	PS00122 Carboxylesterases type-B serine active site
220341004451	Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131
220341004452	Uncharacterized conserved protein [Function unknown]; Region: COG2353
220341004453	L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2.  This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737
220341004454	teramer interface [polypeptide binding]; other site
220341004455	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
220341004456	active site
220341004457	FMN binding site [chemical binding]; other site
220341004458	catalytic residues [active]
220341004459	PS00557 FMN-dependent alpha-hydroxy acid dehydrogenases active site
220341004460	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
220341004461	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
220341004462	Coenzyme A binding pocket [chemical binding]; other site
220341004463	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
220341004464	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
220341004465	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
220341004466	PS00894 Bacterial regulatory proteins, deoR family signature
220341004467	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
220341004468	substrate binding site [chemical binding]; other site
220341004469	hexamer interface [polypeptide binding]; other site
220341004470	metal binding site [ion binding]; metal-binding site
220341004471	PS01086 Ribulose-phosphate 3-epimerase family signature 2
220341004472	PS01085 Ribulose-phosphate 3-epimerase family signature 1
220341004473	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
220341004474	active site
220341004475	phosphorylation site [posttranslational modification]
220341004476	membrane complex biogenesis protein, BtpA family; Region: thylakoid_BtpA; TIGR00259
220341004477	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
220341004478	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
220341004479	active site
220341004480	P-loop; other site
220341004481	phosphorylation site [posttranslational modification]
220341004482	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
220341004483	oligomer interface [polypeptide binding]; other site
220341004484	active site
220341004485	metal binding site [ion binding]; metal-binding site
220341004486	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
220341004487	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
220341004488	Coenzyme A binding pocket [chemical binding]; other site
220341004489	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
220341004490	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
220341004491	putative trimer interface [polypeptide binding]; other site
220341004492	putative CoA binding site [chemical binding]; other site
220341004493	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208
220341004494	putative trimer interface [polypeptide binding]; other site
220341004495	putative CoA binding site [chemical binding]; other site
220341004496	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324
220341004497	gating phenylalanine in ion channel; other site
220341004498	tellurite resistance protein TehB; Provisional; Region: PRK11207
220341004499	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
220341004500	S-adenosylmethionine binding site [chemical binding]; other site
220341004501	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
220341004502	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341004503	Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135
220341004504	benzoate transporter; Region: benE; TIGR00843
220341004505	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
220341004506	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
220341004507	non-specific DNA binding site [nucleotide binding]; other site
220341004508	salt bridge; other site
220341004509	sequence-specific DNA binding site [nucleotide binding]; other site
220341004510	Cupin domain; Region: Cupin_2; pfam07883
220341004511	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
220341004512	Collagenase; Region: DUF3656; pfam12392
220341004513	PS01276 Peptidase family U32 signature
220341004514	Protein of unknown function (DUF2554); Region: DUF2554; pfam10829
220341004515	secreted effector protein SifB; Provisional; Region: sifB; PRK09499
220341004516	D-alanyl-D-alanine dipeptidase [Cell envelope biogenesis, outer membrane]; Region: DdpX; COG2173
220341004517	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
220341004518	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
220341004519	DNA-binding site [nucleotide binding]; DNA binding site
220341004520	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
220341004521	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341004522	homodimer interface [polypeptide binding]; other site
220341004523	catalytic residue [active]
220341004524	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
220341004525	tetrameric interface [polypeptide binding]; other site
220341004526	NAD binding site [chemical binding]; other site
220341004527	catalytic residues [active]
220341004528	substrate binding site [chemical binding]; other site
220341004529	PS00687 Aldehyde dehydrogenases glutamic acid active site
220341004530	Putative bacterial virulence factor; Region: Virul_Fac; cl19867
220341004531	Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfB; COG4457
220341004532	large tegument protein UL36; Provisional; Region: PHA03247
220341004533	Protein of unknown function (DUF2526); Region: DUF2526; pfam10735
220341004534	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
220341004535	putative acetyltransferase; Provisional; Region: PRK03624
220341004536	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
220341004537	Coenzyme A binding pocket [chemical binding]; other site
220341004538	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
220341004539	Prostaglandin dehydrogenases; Region: PGDH; cd05288
220341004540	NAD(P) binding site [chemical binding]; other site
220341004541	substrate binding site [chemical binding]; other site
220341004542	dimer interface [polypeptide binding]; other site
220341004543	colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414
220341004544	DNA-binding site [nucleotide binding]; DNA binding site
220341004545	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
220341004546	FCD domain; Region: FCD; pfam07729
220341004547	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
220341004548	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
220341004549	N-terminal plug; other site
220341004550	ligand-binding site [chemical binding]; other site
220341004551	Uncharacterized conserved protein [Function unknown]; Region: COG3391
220341004552	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
220341004553	PS00017 ATP/GTP-binding site motif A (P-loop)
220341004554	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
220341004555	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341004556	L-asparagine permease; Provisional; Region: PRK15049
220341004557	PS00218 Amino acid permeases signature
220341004558	N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047
220341004559	hypothetical protein; Provisional; Region: PRK10281
220341004560	phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654
220341004561	respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351
220341004562	nitrate reductase 2 subunit delta; Provisional; Region: PRK15054
220341004563	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
220341004564	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
220341004565	Respiratory nitrate reductase beta C-terminal; Region: Nitr_red_bet_C; pfam14711
220341004566	PS00017 ATP/GTP-binding site motif A (P-loop)
220341004567	PS00190 Cytochrome c family heme-binding site signature
220341004568	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
220341004569	Respiratory nitrate reductase alpha N-terminal; Region: Nitr_red_alph_N; pfam14710
220341004570	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
220341004571	[4Fe-4S] binding site [ion binding]; other site
220341004572	molybdopterin cofactor binding site [chemical binding]; other site
220341004573	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
220341004574	molybdopterin cofactor binding site; other site
220341004575	PS00017 ATP/GTP-binding site motif A (P-loop)
220341004576	PS00490 Prokaryotic molybdopterin oxidoreductases signature 2
220341004577	PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature
220341004578	PS00551 Prokaryotic molybdopterin oxidoreductases signature 1
220341004579	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
220341004580	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
220341004581	TetR family transcriptional regulator; Provisional; Region: PRK14996
220341004582	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
220341004583	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
220341004584	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341004585	putative substrate translocation pore; other site
220341004587	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
220341004588	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
220341004589	NAD binding site [chemical binding]; other site
220341004590	substrate binding site [chemical binding]; other site
220341004591	catalytic Zn binding site [ion binding]; other site
220341004592	tetramer interface [polypeptide binding]; other site
220341004593	structural Zn binding site [ion binding]; other site
220341004594	PS00059 Zinc-containing alcohol dehydrogenases signature
220341004595	PS00190 Cytochrome c family heme-binding site signature
220341004596	malate dehydrogenase; Provisional; Region: PRK13529
220341004597	Malic enzyme, N-terminal domain; Region: malic; pfam00390
220341004598	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
220341004599	NAD(P) binding site [chemical binding]; other site
220341004600	PS00331 Malic enzymes signature
220341004601	30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057
220341004602	biofilm-dependent modulation protein; Provisional; Region: PRK11436
220341004603	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
220341004604	Haemolysin E (HlyE); Region: HlyE; cl11627
220341004605	acid-resistance protein; Provisional; Region: hdeB; PRK11566
220341004606	Protein of unknown function (DUF1264); Region: DUF1264; pfam06884
220341004607	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
220341004608	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
220341004609	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
220341004610	catalytic site [active]
220341004611	active site
220341004612	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
220341004613	Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280
220341004614	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
220341004615	active site
220341004616	catalytic site [active]
220341004617	putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350
220341004618	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
220341004619	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341004620	homodimer interface [polypeptide binding]; other site
220341004621	catalytic residue [active]
220341004622	S-adenosylmethionine:tRNA-ribosyltransferase- isomerase (queuine synthetase) [Translation, ribosomal structure and biogenesis]; Region: QueA; COG0809
220341004623	CRISPR/Cas system-associated transcriptional regulator CasRa; Region: CasRa_I-A; cd09655
220341004624	Transcriptional regulators [Transcription]; Region: MarR; COG1846
220341004625	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
220341004626	putative DNA binding site [nucleotide binding]; other site
220341004627	putative Zn2+ binding site [ion binding]; other site
220341004628	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341004629	Major Facilitator Superfamily; Region: MFS_1; pfam07690
220341004630	putative substrate translocation pore; other site
220341004631	PS00216 Sugar transport proteins signature 1
220341004632	PhoPQ-activated pathogenicity-related protein [General function prediction only]; Region: PqaA; COG4287
220341004633	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341004634	D-galactonate transporter; Region: 2A0114; TIGR00893
220341004635	putative substrate translocation pore; other site
220341004636	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
220341004637	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
220341004638	putative NAD(P) binding site [chemical binding]; other site
220341004639	catalytic Zn binding site [ion binding]; other site
220341004640	structural Zn binding site [ion binding]; other site
220341004641	Transcriptional regulators [Transcription]; Region: FadR; COG2186
220341004642	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
220341004643	DNA-binding site [nucleotide binding]; DNA binding site
220341004644	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
220341004645	PS00043 Bacterial regulatory proteins, gntR family signature
220341004646	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
220341004647	active site
220341004648	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341004649	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
220341004650	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
220341004651	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
220341004652	NiFe/NiFeSe hydrogenase small subunit C-terminal; Region: NiFe_hyd_SSU_C; pfam14720
220341004653	PS00507 Nickel-dependent hydrogenases large subunit signature 1
220341004654	PS00508 Nickel-dependent hydrogenases large subunit signature 2
220341004655	Ni,Fe-hydrogenase I cytochrome b subunit [Energy production and conversion]; Region: HyaC; COG1969
220341004656	PS00882 Nickel-dependent hydrogenases b-type cytochrome subunit signature 1
220341004657	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
220341004658	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
220341004659	putative substrate-binding site; other site
220341004660	nickel binding site [ion binding]; other site
220341004661	HupF/HypC family; Region: HupF_HypC; pfam01455
220341004662	HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965
220341004663	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
220341004664	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
220341004665	Rubredoxin [Energy production and conversion]; Region: COG1773
220341004666	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
220341004667	iron binding site [ion binding]; other site
220341004668	PS00017 ATP/GTP-binding site motif A (P-loop)
220341004670	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
220341004671	Predicted membrane protein [Function unknown]; Region: COG3781
220341004672	Domain of unknown function (DUF4186); Region: DUF4186; pfam13811
220341004673	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
220341004674	NAD(P) binding site [chemical binding]; other site
220341004675	catalytic residues [active]
220341004676	PS00070 Aldehyde dehydrogenases cysteine active site
220341004677	Transcriptional regulator [Transcription]; Region: LysR; COG0583
220341004678	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341004679	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
220341004680	putative dimerization interface [polypeptide binding]; other site
220341004681	PS00044 Bacterial regulatory proteins, lysR family signature
220341004682	putative arabinose transporter; Provisional; Region: PRK03545
220341004683	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341004684	putative substrate translocation pore; other site
220341004685	inner membrane protein; Provisional; Region: PRK10995
220341004686	DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512
220341004687	Transcriptional regulators [Transcription]; Region: MarR; COG1846
220341004688	DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511
220341004689	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341004690	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341004691	PS00041 Bacterial regulatory proteins, araC family signature
220341004692	MarB protein; Region: MarB; pfam13999
220341004693	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
220341004694	EamA-like transporter family; Region: EamA; pfam00892
220341004695	EamA-like transporter family; Region: EamA; pfam00892
220341004696	putative transporter; Provisional; Region: PRK10054
220341004697	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341004698	putative substrate translocation pore; other site
220341004699	hypothetical protein; Provisional; Region: PRK10053
220341004700	hypothetical protein; Validated; Region: PRK03657
220341004701	General stress protein [General function prediction only]; Region: GsiB; COG3729
220341004702	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
220341004703	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
220341004704	active site
220341004705	Zn binding site [ion binding]; other site
220341004706	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature
220341004707	malonic semialdehyde reductase; Provisional; Region: PRK10538
220341004708	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
220341004709	putative NAD(P) binding site [chemical binding]; other site
220341004710	homodimer interface [polypeptide binding]; other site
220341004711	homotetramer interface [polypeptide binding]; other site
220341004712	active site
220341004713	PS00061 Short-chain dehydrogenases/reductases family signature
220341004714	Transcriptional regulators [Transcription]; Region: GntR; COG1802
220341004715	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
220341004716	DNA-binding site [nucleotide binding]; DNA binding site
220341004717	FCD domain; Region: FCD; pfam07729
220341004718	PS00043 Bacterial regulatory proteins, gntR family signature
220341004719	putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318
220341004720	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
220341004721	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
220341004722	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
220341004723	PS00974 Mannitol dehydrogenases signature
220341004724	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341004725	metabolite-proton symporter; Region: 2A0106; TIGR00883
220341004726	putative substrate translocation pore; other site
220341004727	putative oxidoreductase; Provisional; Region: PRK10083
220341004728	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
220341004729	NAD(P) binding site [chemical binding]; other site
220341004730	PS00059 Zinc-containing alcohol dehydrogenases signature
220341004731	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
220341004732	The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322
220341004733	putative active site pocket [active]
220341004734	putative metal binding site [ion binding]; other site
220341004735	PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2
220341004736	PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1
220341004737	hypothetical protein; Provisional; Region: PRK02237
220341004738	hypothetical protein; Provisional; Region: PRK13659
220341004739	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
220341004740	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
220341004741	Coenzyme A binding pocket [chemical binding]; other site
220341004742	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
220341004743	Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788
220341004744	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
220341004745	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
220341004746	putative [Fe4-S4] binding site [ion binding]; other site
220341004747	putative molybdopterin cofactor binding site [chemical binding]; other site
220341004748	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
220341004749	putative molybdopterin cofactor binding site; other site
220341004750	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341004751	PS00932 Prokaryotic molybdopterin oxidoreductases signature 3
220341004752	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
220341004753	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
220341004754	putative [Fe4-S4] binding site [ion binding]; other site
220341004755	putative molybdopterin cofactor binding site [chemical binding]; other site
220341004756	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
220341004757	putative molybdopterin cofactor binding site; other site
220341004758	PS00551 Prokaryotic molybdopterin oxidoreductases signature 1
220341004759	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
220341004760	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
220341004761	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341004762	PS00190 Cytochrome c family heme-binding site signature
220341004763	DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302
220341004764	twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621
220341004765	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341004766	dimer interface [polypeptide binding]; other site
220341004767	conserved gate region; other site
220341004768	putative PBP binding loops; other site
220341004769	ABC-ATPase subunit interface; other site
220341004770	PS00402 Binding-protein-dependent transport systems inner membrane comp sign.
220341004771	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
220341004772	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341004773	dimer interface [polypeptide binding]; other site
220341004774	conserved gate region; other site
220341004775	putative PBP binding loops; other site
220341004776	ABC-ATPase subunit interface; other site
220341004777	PS00402 Binding-protein-dependent transport systems inner membrane comp sign.
220341004778	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
220341004779	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
220341004780	Walker A/P-loop; other site
220341004781	ATP binding site [chemical binding]; other site
220341004782	Q-loop/lid; other site
220341004783	ABC transporter signature motif; other site
220341004784	Walker B; other site
220341004785	D-loop; other site
220341004786	H-loop/switch region; other site
220341004787	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582
220341004788	PS00017 ATP/GTP-binding site motif A (P-loop)
220341004789	PS00211 ABC transporters family signature
220341004790	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
220341004791	Cl- selectivity filter; other site
220341004792	Cl- binding residues [ion binding]; other site
220341004793	pore gating glutamate residue; other site
220341004794	dimer interface [polypeptide binding]; other site
220341004795	putative dithiobiotin synthetase; Provisional; Region: PRK12374
220341004796	AAA domain; Region: AAA_26; pfam13500
220341004797	PS00017 ATP/GTP-binding site motif A (P-loop)
220341004798	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
220341004799	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
220341004800	nucleotide binding site [chemical binding]; other site
220341004801	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
220341004802	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
220341004803	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341004804	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
220341004805	dimerization interface [polypeptide binding]; other site
220341004806	substrate binding pocket [chemical binding]; other site
220341004807	PS00044 Bacterial regulatory proteins, lysR family signature
220341004808	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
220341004809	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341004810	putative substrate translocation pore; other site
220341004811	PS00216 Sugar transport proteins signature 1
220341004812	IS200
220341004813	Transposase IS200 like; Region: Y1_Tnp; pfam01797
220341004814	acid shock protein precursor; Provisional; Region: PRK03577
220341004815	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
220341004816	PS00134 Serine proteases, trypsin family, histidine active site
220341004817	PS00135 Serine proteases, trypsin family, serine active site
220341004818	multidrug efflux system protein MdtI; Provisional; Region: PRK10650
220341004819	multidrug efflux system protein MdtJ; Provisional; Region: PRK10452
220341004820	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287
220341004821	pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444
220341004822	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
220341004823	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
220341004824	ligand binding site [chemical binding]; other site
220341004825	homodimer interface [polypeptide binding]; other site
220341004826	NAD(P) binding site [chemical binding]; other site
220341004827	trimer interface B [polypeptide binding]; other site
220341004828	trimer interface A [polypeptide binding]; other site
220341004829	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
220341004830	PS00837 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 2
220341004831	PS00836 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 1
220341004832	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
220341004833	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
220341004834	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
220341004835	Bacteriophage
220341004836	Mor transcription activator family; Region: Mor; pfam08765
220341004837	Protein of unknown function (DUF1018); Region: DUF1018; pfam06252
220341004838	Protein of unknown function (DUF2786); Region: DUF2786; pfam10979
220341004839	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u2; cd11539
220341004840	metal binding site [ion binding]; metal-binding site
220341004841	Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825
220341004842	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
220341004843	AAA domain; Region: AAA_22; pfam13401
220341004844	Walker A motif; other site
220341004845	ATP binding site [chemical binding]; other site
220341004846	Walker B motif; other site
220341004847	arginine finger; other site
220341004848	Integrase core domain; Region: rve; pfam00665
220341004849	Protein of unknown function (DUF4063); Region: DUF4063; pfam13272
220341004850	phage lambda Rz-like lysis protein; Region: PHA00276
220341004851	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341004852	Protein of unknown function (DUF3486); Region: DUF3486; pfam11985
220341004853	Phage Terminase; Region: Terminase_1; cl19862
220341004854	Terminase-like family; Region: Terminase_6; pfam03237
220341004855	Protein of unknown function (DUF935); Region: DUF935; pfam06074
220341004856	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
220341004857	Phage virion morphogenesis family; Region: Phage_tail_S; cl02089
220341004858	Protein of unknown function (DUF1320); Region: DUF1320; pfam07030
220341004859	Gp37 protein; Region: Gp37; pfam09646
220341004860	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
220341004861	phage contractile tail tube protein, P2 family; Region: tail_tube; TIGR01611
220341004862	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
220341004863	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050
220341004864	Phage P2 GpU; Region: Phage_P2_GpU; pfam06995
220341004865	Phage Tail Protein X; Region: Phage_tail_X; pfam05489
220341004866	Phage protein D [General function prediction only]; Region: COG3500
220341004867	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
220341004868	Phage baseplate assembly protein W [General function prediction only]; Region: COG3628
220341004869	Baseplate J-like protein; Region: Baseplate_J; cl01294
220341004870	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684
220341004871	Protein of unknown function (DUF1002); Region: DUF1002; cl19854
220341004872	Phage Tail Collar Domain; Region: Collar; pfam07484
220341004873	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
220341004874	multiple promoter invertase; Provisional; Region: mpi; PRK13413
220341004875	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
220341004876	catalytic residues [active]
220341004877	catalytic nucleophile [active]
220341004878	Presynaptic Site I dimer interface [polypeptide binding]; other site
220341004879	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
220341004880	Synaptic Flat tetramer interface [polypeptide binding]; other site
220341004881	Synaptic Site I dimer interface [polypeptide binding]; other site
220341004882	DNA binding site [nucleotide binding]
220341004883	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569
220341004884	DNA-binding interface [nucleotide binding]; DNA binding site
220341004885	PS00397 Site-specific recombinases active site
220341004886	PS00398 Site-specific recombinases signature 2
220341004887	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
220341004888	Spore germination protein; Region: Spore_permease; cl17796
220341004889	GlpM protein; Region: GlpM; pfam06942
220341004890	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
220341004891	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
220341004892	active site
220341004893	phosphorylation site [posttranslational modification]
220341004894	intermolecular recognition site; other site
220341004895	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
220341004896	DNA binding site [nucleotide binding]
220341004897	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
220341004898	trimer interface [polypeptide binding]; other site
220341004899	eyelet of channel; other site
220341004900	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
220341004901	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
220341004902	active site
220341004903	sensor protein RstB; Provisional; Region: PRK10604
220341004904	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
220341004905	dimerization interface [polypeptide binding]; other site
220341004906	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
220341004907	dimer interface [polypeptide binding]; other site
220341004908	phosphorylation site [posttranslational modification]
220341004909	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
220341004910	ATP binding site [chemical binding]; other site
220341004911	Mg2+ binding site [ion binding]; other site
220341004912	G-X-G motif; other site
220341004913	DNA replication terminus site-binding protein; Provisional; Region: PRK02951
220341004914	fumarate hydratase; Reviewed; Region: fumC; PRK00485
220341004915	Class II fumarases; Region: Fumarase_classII; cd01362
220341004916	active site
220341004917	tetramer interface [polypeptide binding]; other site
220341004918	PS00163 Fumarate lyases signature
220341004919	fumarate hydratase; Provisional; Region: PRK15389
220341004920	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951
220341004921	Fumarase C-terminus; Region: Fumerase_C; pfam05683
220341004922	PS00163 Fumarate lyases signature
220341004923	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
220341004924	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
220341004925	PS00965 Phosphomannose isomerase type I signature 1
220341004926	PS00966 Phosphomannose isomerase type I signature 2
220341004927	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
220341004928	PS00017 ATP/GTP-binding site motif A (P-loop)
220341004930	Gene remnant. Similar to N-terminus of Escherichia coli MalY protein malY SW:MALY_ECOLI (P23256) (390 aa) fasta scores: E(): 3.7e-17, 88.6% id in 44 aa
220341004931	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
220341004932	active site
220341004933	purine riboside binding site [chemical binding]; other site
220341004934	PS00485 Adenosine and AMP deaminase signature
220341004935	putative oxidoreductase; Provisional; Region: PRK11579
220341004936	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
220341004937	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
220341004938	oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391
220341004939	Protein of unknown function (DUF2569); Region: DUF2569; pfam10754
220341004940	electron transport complex protein RsxA; Provisional; Region: PRK05151
220341004941	electron transport complex protein RnfB; Provisional; Region: PRK05113
220341004942	Putative Fe-S cluster; Region: FeS; cl17515
220341004943	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
220341004944	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341004945	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341004946	electron transport complex protein RnfC; Provisional; Region: PRK05035
220341004947	RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375
220341004948	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
220341004949	SLBB domain; Region: SLBB; pfam10531
220341004950	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
220341004951	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341004952	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341004953	electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816
220341004954	electron transport complex protein RnfG; Validated; Region: PRK01908
220341004955	electron transport complex RsxE subunit; Provisional; Region: PRK12405
220341004956	endonuclease III; Provisional; Region: PRK10702
220341004957	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
220341004958	minor groove reading motif; other site
220341004959	helix-hairpin-helix signature motif; other site
220341004960	substrate binding pocket [chemical binding]; other site
220341004961	active site
220341004962	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
220341004963	PS01155 Endonuclease III family signature
220341004964	PS00764 Endonuclease III iron-sulfur binding region signature
220341004965	putative tripeptide transporter permease; Reviewed; Region: tppB; PRK09584
220341004966	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
220341004967	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341004968	putative substrate translocation pore; other site
220341004969	PS01022 PTR2 family proton/oligopeptide symporters signature 1
220341004970	PS00778 Histidine acid phosphatases active site signature
220341004971	PS01023 PTR2 family proton/oligopeptide symporters signature 2
220341004972	glutathionine S-transferase; Provisional; Region: PRK10542
220341004973	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
220341004974	C-terminal domain interface [polypeptide binding]; other site
220341004975	GSH binding site (G-site) [chemical binding]; other site
220341004976	dimer interface [polypeptide binding]; other site
220341004977	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
220341004978	dimer interface [polypeptide binding]; other site
220341004979	N-terminal domain interface [polypeptide binding]; other site
220341004980	substrate binding pocket (H-site) [chemical binding]; other site
220341004981	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
220341004982	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
220341004983	active site
220341004984	HIGH motif; other site
220341004985	dimer interface [polypeptide binding]; other site
220341004986	KMSKS motif; other site
220341004987	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
220341004988	RNA binding surface [nucleotide binding]; other site
220341004989	PS00178 Aminoacyl-transfer RNA synthetases class-I signature
220341004990	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
220341004991	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
220341004992	Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590
220341004993	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341004994	Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702
220341004995	Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133
220341004996	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341004997	transcriptional regulator SlyA; Provisional; Region: PRK03573
220341004998	Transcriptional regulators [Transcription]; Region: MarR; COG1846
220341004999	PS01117 Bacterial regulatory proteins, marR family signature
220341005000	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
220341005001	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
220341005002	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
220341005003	HlyD family secretion protein; Region: HlyD_3; pfam13437
220341005004	Fusaric acid resistance protein family; Region: FUSC; pfam04632
220341005005	Fusaric acid resistance protein-like; Region: FUSC_2; cl19401
220341005006	RNA polymerase Rpb4; Region: RNA_pol_Rpb4; cl00638
220341005007	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
220341005008	E-class dimer interface [polypeptide binding]; other site
220341005009	P-class dimer interface [polypeptide binding]; other site
220341005010	active site
220341005011	Cu2+ binding site [ion binding]; other site
220341005012	Zn2+ binding site [ion binding]; other site
220341005013	PS00332 Copper/Zinc superoxide dismutase signature 2
220341005014	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
220341005015	active site
220341005016	catalytic tetrad [active]
220341005017	Predicted Fe-S protein [General function prediction only]; Region: COG3313
220341005018	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
220341005019	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
220341005020	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
220341005021	FMN binding site [chemical binding]; other site
220341005022	active site
220341005023	substrate binding site [chemical binding]; other site
220341005024	catalytic residue [active]
220341005025	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
220341005026	dimer interface [polypeptide binding]; other site
220341005027	active site
220341005028	metal binding site [ion binding]; metal-binding site
220341005029	glutathione binding site [chemical binding]; other site
220341005030	PS00934 Glyoxalase I signature 1
220341005031	PS00935 Glyoxalase I signature 2
220341005032	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
220341005033	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
220341005034	dimer interface [polypeptide binding]; other site
220341005035	catalytic site [active]
220341005036	putative active site [active]
220341005037	putative substrate binding site [chemical binding]; other site
220341005038	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
220341005039	putative GSH binding site [chemical binding]; other site
220341005040	catalytic residues [active]
220341005041	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
220341005042	NlpC/P60 family; Region: NLPC_P60; pfam00877
220341005043	superoxide dismutase; Provisional; Region: PRK10543
220341005044	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
220341005045	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
220341005046	PS00088 Manganese and iron superoxide dismutases signature
220341005047	DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703
220341005048	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
220341005049	DNA binding site [nucleotide binding]
220341005050	domain linker motif; other site
220341005051	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
220341005052	dimerization interface [polypeptide binding]; other site
220341005053	ligand binding site [chemical binding]; other site
220341005054	PS00356 Bacterial regulatory proteins, lacI family signature
220341005055	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
220341005056	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341005057	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
220341005058	dimerization interface [polypeptide binding]; other site
220341005059	PS00044 Bacterial regulatory proteins, lysR family signature
220341005060	putative transporter; Provisional; Region: PRK11043
220341005061	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341005062	putative substrate translocation pore; other site
220341005063	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
220341005064	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
220341005065	S-adenosylmethionine binding site [chemical binding]; other site
220341005066	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
220341005067	Lumazine binding domain; Region: Lum_binding; pfam00677
220341005068	Lumazine binding domain; Region: Lum_binding; pfam00677
220341005069	PS00693 Riboflavin synthase alpha chain family signature
220341005070	multidrug efflux protein; Reviewed; Region: PRK01766
220341005071	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
220341005072	cation binding site [ion binding]; other site
220341005073	Salmonella Pathogenicity Island 2. This appears to be the product of at least two independant insertions, either side of the gene STY1732 which is conserved in E. coli.
220341005074	secretion system apparatus protein SsaU; Reviewed; Region: PRK12721
220341005075	type III secretion system protein SsaT; Provisional; Region: PRK15349
220341005076	type III secretion system protein SsaS; Provisional; Region: PRK15350
220341005077	Type III secretory pathway, component EscR [Intracellular trafficking and secretion]; Region: EscR; COG4790
220341005078	PS01061 Flagella transport protein fliP family signature 2
220341005079	PS01060 Flagella transport protein fliP family signature 1
220341005080	type III secretion system protein SsaQ; Validated; Region: PRK08035
220341005081	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
220341005082	type III secretion system protein SsaP; Provisional; Region: PRK15351
220341005083	type III secretion system protein SsaO; Provisional; Region: PRK15352
220341005084	type III secretion system ATPase SsaN; Validated; Region: PRK07594
220341005085	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
220341005086	Walker A motif/ATP binding site; other site
220341005087	Walker B motif; other site
220341005088	secretion system apparatus protein SsaV; Provisional; Region: PRK12720
220341005089	PS00994 Bacterial export FHIPEP family signature
220341005090	type III secretion system protein SsaM; Provisional; Region: PRK15353
220341005091	type III secretion system protein SsaL; Provisional; Region: PRK15345
220341005092	HrpJ-like domain; Region: HrpJ; pfam07201
220341005093	TyeA; Region: TyeA; cl07611
220341005094	type III secretion system protein SsaK; Provisional; Region: PRK15354
220341005095	type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499
220341005096	Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327
220341005097	type III secretion system lipoprotein SsaJ; Provisional; Region: PRK15348
220341005098	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341005099	type III secretion system protein SsaI; Provisional; Region: PRK15355
220341005100	type III secretion system protein SsaH; Provisional; Region: PRK15356
220341005101	type III secretion system needle protein SsaG; Provisional; Region: PRK15344
220341005102	pathogenicity island 2 effector protein SseG; Provisional; Region: PRK15357
220341005103	pathogenicity island 2 effector protein SseF; Provisional; Region: PRK15358
220341005104	type III secretion system chaperone protein SscB; Provisional; Region: PRK15359
220341005105	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
220341005106	TPR motif; other site
220341005107	binding surface
220341005108	pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360
220341005109	pathogenicity island 2 effector protein SseD; Provisional; Region: PRK15361
220341005110	pathogenicity island 2 effector protein SseC; Provisional; Region: PRK15362
220341005111	Secretion system effector C (SseC) like family; Region: SseC; pfam04888
220341005112	pathogenicity island 2 chaperone protein SscA; Provisional; Region: PRK15363
220341005113	pathogenicity island 2 effector protein SseB; Provisional; Region: PRK15364
220341005114	type III secretion system chaperone SseA; Provisional; Region: PRK15365
220341005115	type III secretion system chaperone SsaE; Provisional; Region: PRK15366
220341005116	type III secretion system protein SsaD; Provisional; Region: PRK15367
220341005117	type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500
220341005118	outer membrane secretin SsaC; Provisional; Region: PRK15346
220341005119	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
220341005120	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
220341005121	pathogenicity island chaperone protein SpiC; Provisional; Region: PRK15368
220341005122	two component system sensor kinase SsrA; Provisional; Region: PRK15347
220341005123	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
220341005124	dimerization interface [polypeptide binding]; other site
220341005125	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
220341005126	dimer interface [polypeptide binding]; other site
220341005127	phosphorylation site [posttranslational modification]
220341005128	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
220341005129	ATP binding site [chemical binding]; other site
220341005130	Mg2+ binding site [ion binding]; other site
220341005131	G-X-G motif; other site
220341005132	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
220341005133	active site
220341005134	phosphorylation site [posttranslational modification]
220341005135	intermolecular recognition site; other site
220341005136	dimerization interface [polypeptide binding]; other site
220341005137	two component system sensor kinase SsrB; Provisional; Region: PRK15369
220341005138	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
220341005139	active site
220341005140	phosphorylation site [posttranslational modification]
220341005141	intermolecular recognition site; other site
220341005142	dimerization interface [polypeptide binding]; other site
220341005143	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
220341005144	DNA binding residues [nucleotide binding]
220341005145	dimerization interface [polypeptide binding]; other site
220341005146	PS00622 Bacterial regulatory proteins, luxR family signature
220341005147	transcriptional regulator MirA; Provisional; Region: PRK15043
220341005148	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
220341005149	DNA binding residues [nucleotide binding]
220341005150	PS00552 Bacterial regulatory proteins, merR family signature
220341005151	Uncharacterized conserved protein [Function unknown]; Region: COG1683
220341005152	Uncharacterized conserved protein [Function unknown]; Region: COG3272
220341005153	hypothetical protein; Provisional; Region: PRK10292
220341005154	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
220341005155	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
220341005156	active site
220341005157	phosphorylation site [posttranslational modification]
220341005158	intermolecular recognition site; other site
220341005159	dimerization interface [polypeptide binding]; other site
220341005160	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
220341005161	DNA binding residues [nucleotide binding]
220341005162	dimerization interface [polypeptide binding]; other site
220341005163	PS00622 Bacterial regulatory proteins, luxR family signature
220341005164	Sensor kinase pseudogene. Similar to Salmonella typhimurium TtrS TR:Q9Z4S9 (EMBL:AJ224978) (559 aa) fasta scores: E(): 0, 99.8% id in 435 aa. This CDS contains a frameshift after codon 476. The sequence has been checked and is believed to be correct
220341005165	tetrathionate reductase subunit B; Provisional; Region: PRK14993
220341005166	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
220341005167	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341005168	tetrathionate reductase subunit C; Provisional; Region: PRK14992
220341005169	tetrathionate reductase subunit A; Provisional; Region: PRK14991
220341005170	The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758
220341005171	putative [Fe4-S4] binding site [ion binding]; other site
220341005172	putative molybdopterin cofactor binding site [chemical binding]; other site
220341005173	This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
220341005174	putative molybdopterin cofactor binding site; other site
220341005175	Putative ribokinase pseudogene. Similar to Salmonella typhimurium Orf 408 protein orf 408 TR:Q9Z4S5 (EMBL:AJ224978) (408 aa) fasta scores: E(): 0, 98.8% id in 345 aa, and to Lactobacillus sake ribokinase RbsK rbsK TR:Q9X4M5 (EMBL:AF115391) (302 aa) fasta scores: E(): 8.6e-26, 37.8% id in 251 aa, and to Escherichia coli ribokinase rbsK SW:RBSK_ECOLI (P05054) (309 aa) fasta scores: E(): 9e-25, 34.6% id in 254 aa. This CDS contains a 7bp internal deletion and consequent frameshift after codon 345. The sequence has been checked and is believed to be correct
220341005176	PS00583 pfkB family of carbohydrate kinases signature 1
220341005177	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
220341005179	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
220341005180	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
220341005181	pyruvate kinase; Provisional; Region: PRK09206
220341005182	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
220341005183	domain interfaces; other site
220341005184	active site
220341005185	PS00110 Pyruvate kinase active site signature
220341005186	murein lipoprotein; Provisional; Region: PRK15396
220341005187	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341005188	murein lipoprotein; Provisional; Region: PRK15396
220341005189	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341005190	Conserved hypothetical pseudogene. Similar to Escherichia coli hypothetical 36.1 kDa protein in lpp-aroD intergenic region precursor YnhG SW:YNHG_ECOLI (P76193; P76899; P76900) (334 aa) fasta scores: E(): 0, 89.0% id in 109 aa, and to Escherichia coli hypothetical 34.6 kDa protein in ndh-mfd intergenic region precursor YcfS SW:YCFS_ECOLI (P75954) (320 aa) fasta scores: E(): 9.9e-15, 42.1% id in 114 aa. This CDS contains a frameshift after codon 109. The sequence has been checked and is believed to be correct
220341005191	cysteine desufuration protein SufE; Provisional; Region: PRK09296
220341005192	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
220341005193	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
220341005194	catalytic residue [active]
220341005195	cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948
220341005196	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
220341005197	cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580
220341005198	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
220341005199	Walker A/P-loop; other site
220341005200	ATP binding site [chemical binding]; other site
220341005201	Q-loop/lid; other site
220341005202	ABC transporter signature motif; other site
220341005203	Walker B; other site
220341005204	D-loop; other site
220341005205	H-loop/switch region; other site
220341005206	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
220341005207	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
220341005208	iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504
220341005209	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
220341005210	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
220341005211	CoenzymeA binding site [chemical binding]; other site
220341005212	subunit interaction site [polypeptide binding]; other site
220341005213	PHB binding site; other site
220341005214	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
220341005215	FAD binding domain; Region: FAD_binding_4; pfam01565
220341005216	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
220341005217	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
220341005218	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
220341005219	putative inner membrane protein; Provisional; Region: PRK10983
220341005220	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
220341005221	active site
220341005222	catalytic residue [active]
220341005223	dimer interface [polypeptide binding]; other site
220341005224	PS01028 Dehydroquinase class I active site
220341005225	phosphoenolpyruvate synthase; Validated; Region: PRK06464
220341005226	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
220341005227	PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391
220341005228	PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
220341005229	PS00742 PEP-utilizing enzymes signature 2
220341005230	PS00370 PEP-utilizing enzymes phosphorylation site signature
220341005231	PEP synthetase regulatory protein; Provisional; Region: PRK05339
220341005232	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756
220341005233	hypothetical protein; Provisional; Region: PRK10183
220341005234	hypothetical protein; Validated; Region: PRK00029
220341005235	c-di-GMP phosphodiesterase class I (EAL domain) [Signal    transduction mechanisms]; Region: Rtn; COG2200
220341005236	NlpC/P60 family; Region: NLPC_P60; pfam00877
220341005237	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341005238	ABC-type cobalamin transport system, ATPase component [Coenzyme metabolism]; Region: BtuD; COG4138
220341005239	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
220341005240	Walker A/P-loop; other site
220341005241	ATP binding site [chemical binding]; other site
220341005242	Q-loop/lid; other site
220341005243	ABC transporter signature motif; other site
220341005244	Walker B; other site
220341005245	D-loop; other site
220341005246	H-loop/switch region; other site
220341005247	PS00211 ABC transporters family signature
220341005248	PS00017 ATP/GTP-binding site motif A (P-loop)
220341005249	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
220341005250	catalytic residues [active]
220341005251	dimer interface [polypeptide binding]; other site
220341005252	PS00763 Glutathione peroxidases signature 2
220341005253	PS00460 Glutathione peroxidases selenocysteine active site
220341005254	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
220341005255	ABC-ATPase subunit  interface; other site
220341005256	dimer interface [polypeptide binding]; other site
220341005257	putative PBP binding regions; other site
220341005258	Alpha subunit of integration host factor (IHFA); Region: IHF_A; cd13835
220341005259	DNA binding site [nucleotide binding]
220341005260	dimer interface [polypeptide binding]; other site
220341005261	PS00045 Bacterial histone-like DNA-binding proteins signature
220341005262	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
220341005263	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
220341005264	putative tRNA-binding site [nucleotide binding]; other site
220341005265	B3/4 domain; Region: B3_4; pfam03483
220341005266	tRNA synthetase B5 domain; Region: B5; smart00874
220341005267	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
220341005268	dimer interface [polypeptide binding]; other site
220341005269	motif 1; other site
220341005270	motif 3; other site
220341005271	motif 2; other site
220341005272	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
220341005273	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
220341005274	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
220341005275	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
220341005276	dimer interface [polypeptide binding]; other site
220341005277	motif 1; other site
220341005278	active site
220341005279	motif 2; other site
220341005280	motif 3; other site
220341005281	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2
220341005282	PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1
220341005283	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
220341005284	23S rRNA binding site [nucleotide binding]; other site
220341005285	L21 binding site [polypeptide binding]; other site
220341005286	L13 binding site [polypeptide binding]; other site
220341005287	PS00937 Ribosomal protein L20 signature
220341005288	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
220341005289	PS00936 Ribosomal protein L35 signature
220341005290	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
220341005291	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
220341005292	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
220341005293	PS00938 Initiation factor 3 signature
220341005294	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
220341005295	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
220341005296	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
220341005297	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
220341005298	active site
220341005299	dimer interface [polypeptide binding]; other site
220341005300	motif 1; other site
220341005301	motif 2; other site
220341005302	motif 3; other site
220341005303	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
220341005304	anticodon binding site; other site
220341005305	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2
220341005306	PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1
220341005307	PS01156 TonB-dependent receptor proteins signature 2
220341005308	PS01070 DNA/RNA non-specific endonucleases active site
220341005309	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3528
220341005310	Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137
220341005311	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
220341005312	putative substrate binding site [chemical binding]; other site
220341005313	putative ATP binding site [chemical binding]; other site
220341005314	PS00583 pfkB family of carbohydrate kinases signature 1
220341005315	PS00584 pfkB family of carbohydrate kinases signature 2
220341005316	Protein of unknown function (DUF2622); Region: DUF2622; pfam11080
220341005317	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3001
220341005318	Phosphotransferase enzyme family; Region: APH; pfam01636
220341005319	YniB-like protein; Region: YniB; pfam14002
220341005320	2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826
220341005321	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
220341005322	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
220341005323	motif II; other site
220341005324	inner membrane protein; Provisional; Region: PRK11648
220341005325	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
220341005326	cell division modulator; Provisional; Region: PRK10113
220341005327	hydroperoxidase II; Provisional; Region: katE; PRK11249
220341005328	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
220341005329	tetramer interface [polypeptide binding]; other site
220341005330	heme binding pocket [chemical binding]; other site
220341005331	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
220341005332	domain interactions; other site
220341005333	PS00438 Catalase proximal active site signature
220341005334	PS00437 Catalase proximal heme-ligand signature
220341005335	Insertion element IS200
220341005336	Transposase IS200 like; Region: Y1_Tnp; pfam01797
220341005337	Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803
220341005338	putative active site [active]
220341005339	YdjC motif; other site
220341005340	Mg binding site [ion binding]; other site
220341005341	putative homodimer interface [polypeptide binding]; other site
220341005342	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
220341005343	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
220341005344	NAD binding site [chemical binding]; other site
220341005345	sugar binding site [chemical binding]; other site
220341005346	divalent metal binding site [ion binding]; other site
220341005347	tetramer (dimer of dimers) interface [polypeptide binding]; other site
220341005348	dimer interface [polypeptide binding]; other site
220341005349	PS01324 Glycosyl hydrolases family 4 signature
220341005350	DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296
220341005351	Cupin domain; Region: Cupin_2; cl17218
220341005352	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341005353	PS00041 Bacterial regulatory proteins, araC family signature
220341005354	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
220341005355	methionine cluster; other site
220341005356	active site
220341005357	phosphorylation site [posttranslational modification]
220341005358	metal binding site [ion binding]; metal-binding site
220341005359	PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297
220341005360	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
220341005361	active site
220341005362	P-loop; other site
220341005363	phosphorylation site [posttranslational modification]
220341005364	DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251
220341005365	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341005366	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
220341005367	homodimer interface [polypeptide binding]; other site
220341005368	NAD binding pocket [chemical binding]; other site
220341005369	ATP binding pocket [chemical binding]; other site
220341005370	Mg binding site [ion binding]; other site
220341005371	active-site loop [active]
220341005372	nucleotide excision repair endonuclease; Provisional; Region: PRK10545
220341005373	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
220341005374	GIY-YIG motif/motif A; other site
220341005375	active site
220341005376	catalytic site [active]
220341005377	putative DNA binding site [nucleotide binding]; other site
220341005378	metal binding site [ion binding]; metal-binding site
220341005379	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
220341005380	dimer interface [polypeptide binding]; other site
220341005381	Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855
220341005382	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
220341005383	putative active site [active]
220341005384	Zn binding site [ion binding]; other site
220341005385	succinylarginine dihydrolase; Provisional; Region: PRK13281
220341005386	PS00070 Aldehyde dehydrogenases cysteine active site
220341005387	PS00687 Aldehyde dehydrogenases glutamic acid active site
220341005388	arginine succinyltransferase; Provisional; Region: PRK10456
220341005389	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
220341005390	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
220341005391	inhibitor-cofactor binding pocket; inhibition site
220341005392	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341005393	catalytic residue [active]
220341005394	PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site
220341005395	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
220341005396	putative catalytic site [active]
220341005397	putative phosphate binding site [ion binding]; other site
220341005398	active site
220341005399	metal binding site A [ion binding]; metal-binding site
220341005400	DNA binding site [nucleotide binding]
220341005401	putative AP binding site [nucleotide binding]; other site
220341005402	putative metal binding site B [ion binding]; other site
220341005403	PS00726 AP endonucleases family 1 signature 1
220341005404	PS00728 AP endonucleases family 1 signature 3
220341005405	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
220341005406	active site
220341005407	8-oxo-dGMP binding site [chemical binding]; other site
220341005408	nudix motif; other site
220341005409	metal binding site [ion binding]; metal-binding site
220341005410	PS00893 mutT domain signature
220341005411	Protein of unknown function (DUF1496); Region: DUF1496; pfam07383
220341005412	glutamate dehydrogenase; Provisional; Region: PRK09414
220341005413	Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812
220341005414	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
220341005415	NAD(P) binding site [chemical binding]; other site
220341005416	PS00074 Glu / Leu / Phe / Val dehydrogenases active site
220341005417	DNA topoisomerase III; Provisional; Region: PRK07726
220341005418	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
220341005419	active site
220341005420	putative interdomain interaction site [polypeptide binding]; other site
220341005421	putative metal-binding site [ion binding]; other site
220341005422	putative nucleotide binding site [chemical binding]; other site
220341005423	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
220341005424	domain I; other site
220341005425	DNA binding groove [nucleotide binding]
220341005426	phosphate binding site [ion binding]; other site
220341005427	domain II; other site
220341005428	domain III; other site
220341005429	nucleotide binding site [chemical binding]; other site
220341005430	catalytic site [active]
220341005431	domain IV; other site
220341005432	PS00396 Prokaryotic DNA topoisomerase I active site
220341005433	selenophosphate synthetase; Provisional; Region: PRK00943
220341005434	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
220341005435	dimerization interface [polypeptide binding]; other site
220341005436	putative ATP binding site [chemical binding]; other site
220341005437	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
220341005438	putative FMN binding site [chemical binding]; other site
220341005439	protease 4; Provisional; Region: PRK10949
220341005440	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
220341005441	tandem repeat interface [polypeptide binding]; other site
220341005442	oligomer interface [polypeptide binding]; other site
220341005443	active site residues [active]
220341005444	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019
220341005445	tandem repeat interface [polypeptide binding]; other site
220341005446	oligomer interface [polypeptide binding]; other site
220341005447	active site residues [active]
220341005448	cytoplasmic asparaginase I; Provisional; Region: ansA; PRK09461
220341005449	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
220341005450	active site
220341005451	homodimer interface [polypeptide binding]; other site
220341005452	PS00144 Asparaginase / glutaminase active site signature 1
220341005453	PS00917 Asparaginase / glutaminase active site signature 2
220341005454	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
220341005455	catalytic triad [active]
220341005456	metal binding site [ion binding]; metal-binding site
220341005457	conserved cis-peptide bond; other site
220341005458	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139
220341005459	methionine sulfoxide reductase B; Provisional; Region: PRK00222
220341005460	glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425
220341005461	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
220341005462	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
220341005463	PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site
220341005464	conserved hypothetical pseudogene. Similar to many e.g. Escherichia coli unknown protein from 2d-page yeaD SW:UP08_ECOLI (P39173; P76913; P76233) (294 aa) fasta scores: E(): 0, 80.5% id in 236 aa, and to Drosophila melanogaster Bg:ds00797.2 protein bg:ds00797.2 TR:Q9V3D1 (EMBL:AE003641) (297 aa) fasta scores: E(): 4.9e-10, 32.0% id in 231 aa. This CDS contains an in-frame stop at codon 50
220341005465	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
220341005466	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
220341005467	active site
220341005468	catalytic tetrad [active]
220341005469	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
220341005470	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
220341005471	FeS/SAM binding site; other site
220341005472	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
220341005473	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
220341005474	PrkA family serine protein kinase; Provisional; Region: PRK15455
220341005475	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
220341005476	Walker A motif; other site
220341005477	ATP binding site [chemical binding]; other site
220341005478	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
220341005479	hypothetical protein; Provisional; Region: PRK05325
220341005480	YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function.  The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336
220341005481	putative deacylase active site [active]
220341005482	Predicted membrane protein [Function unknown]; Region: COG2707
220341005483	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
220341005484	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
220341005485	PS00041 Bacterial regulatory proteins, araC family signature
220341005486	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
220341005487	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341005488	putative substrate translocation pore; other site
220341005489	Uncharacterized conserved protein [Function unknown]; Region: COG3189
220341005490	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
220341005491	Insertion element IS200
220341005492	Transposase IS200 like; Region: Y1_Tnp; pfam01797
220341005493	hypothetical protein; Provisional; Region: PRK10457
220341005494	Domain of unknown function (DUF1869); Region: DUF1869; pfam08956
220341005495	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
220341005496	leucine export protein LeuE; Provisional; Region: PRK10958
220341005497	chorismate mutase; Provisional; Region: PRK08055
220341005498	Pleckstrin homology-like domain; Region: PH-like; cl17171
220341005499	Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798
220341005500	transcriptional regulator MirA; Provisional; Region: PRK15043
220341005501	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
220341005502	DNA binding residues [nucleotide binding]
220341005503	dimer interface [polypeptide binding]; other site
220341005504	PS00552 Bacterial regulatory proteins, merR family signature
220341005505	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
220341005506	DNA binding residues [nucleotide binding]
220341005507	aminoglycoside resistance protein; Provisional; Region: PRK13746
220341005508	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
220341005509	active site
220341005510	NTP binding site [chemical binding]; other site
220341005511	metal binding triad [ion binding]; metal-binding site
220341005512	antibiotic binding site [chemical binding]; other site
220341005513	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
220341005514	zinc/cadmium-binding protein; Provisional; Region: PRK10306
220341005515	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
220341005516	dimerization interface [polypeptide binding]; other site
220341005517	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
220341005518	Mechanosensitive ion channel; Region: MS_channel; pfam00924
220341005519	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
220341005520	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
220341005521	Walker A/P-loop; other site
220341005522	ATP binding site [chemical binding]; other site
220341005523	Q-loop/lid; other site
220341005524	ABC transporter signature motif; other site
220341005525	Walker B; other site
220341005526	D-loop; other site
220341005527	H-loop/switch region; other site
220341005528	PS00211 ABC transporters family signature
220341005529	PS00017 ATP/GTP-binding site motif A (P-loop)
220341005530	PS00017 ATP/GTP-binding site motif A (P-loop)
220341005531	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
220341005532	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
220341005533	Walker A/P-loop; other site
220341005534	ATP binding site [chemical binding]; other site
220341005535	Q-loop/lid; other site
220341005536	ABC transporter signature motif; other site
220341005537	Walker B; other site
220341005538	D-loop; other site
220341005539	H-loop/switch region; other site
220341005540	PS00017 ATP/GTP-binding site motif A (P-loop)
220341005541	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
220341005542	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341005543	dimer interface [polypeptide binding]; other site
220341005544	conserved gate region; other site
220341005545	putative PBP binding loops; other site
220341005546	ABC-ATPase subunit interface; other site
220341005547	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
220341005548	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341005549	dimer interface [polypeptide binding]; other site
220341005550	conserved gate region; other site
220341005551	putative PBP binding loops; other site
220341005552	ABC-ATPase subunit interface; other site
220341005553	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
220341005554	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518
220341005555	TRL-like protein family; Region: TRL; pfam13146
220341005556	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341005557	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
220341005558	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
220341005559	BNR repeat-like domain; Region: BNR_2; pfam13088
220341005560	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
220341005561	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
220341005562	putative dimer interface [polypeptide binding]; other site
220341005563	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341005564	lysozyme inhibitor; Provisional; Region: PRK13791
220341005565	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
220341005566	PS00695 Enterobacterial virulence outer membrane protein signature 2
220341005567	PS00694 Enterobacterial virulence outer membrane protein signature 1
220341005568	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
220341005569	DNA-binding site [nucleotide binding]; DNA binding site
220341005570	RNA-binding motif; other site
220341005571	Ricin-type beta-trefoil; Region: RICIN; smart00458
220341005572	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
220341005573	putative sugar binding sites [chemical binding]; other site
220341005574	Q-X-W motif; other site
220341005575	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341005576	DinI-like family; Region: DinI; pfam06183
220341005577	Possible integrase fragment. Similar to Escherichia coli l0006 TR:O85613 (EMBL:AF071034) (217 aa) fasta scores: E(): 1.5e-11, 63.9% id in 61 aa, and to Escherichia coli O157:H7 orfb of IS911 l7046 TR:Q9ZGT6 (EMBL:AF074613) (273 aa) fasta scores: E(): 0.00065, 52.5% id in 40 aa
220341005578	CdtB, the catalytic DNase I-like subunit of cytolethal distending toxin (CDT) protein; Region: CdtB; cd09081
220341005579	putative catalytic site [active]
220341005580	CdtC interface [polypeptide binding]; other site
220341005581	heterotrimer interface [polypeptide binding]; other site
220341005582	CdtA interface [polypeptide binding]; other site
220341005583	putative metal binding site [ion binding]; other site
220341005584	putative phosphate binding site [ion binding]; other site
220341005585	Lysozyme family protein [General function prediction only]; Region: zliS; COG3926
220341005586	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
220341005587	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
220341005588	subtilase cytotoxin subunit B; Provisional; Region: PRK15266
220341005589	Protein of unknown function (DUF3626); Region: DUF3626; pfam12294
220341005590	Insertion element IS200
220341005591	Transposase IS200 like; Region: Y1_Tnp; pfam01797
220341005592	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877
220341005593	hypothetical protein; Provisional; Region: PRK10941
220341005594	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
220341005595	hypothetical protein; Provisional; Region: PRK10278
220341005596	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
220341005597	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
220341005598	S-adenosylmethionine binding site [chemical binding]; other site
220341005599	peptide chain release factor 1; Validated; Region: prfA; PRK00591
220341005600	This domain is found in peptide chain release factors; Region: PCRF; smart00937
220341005601	RF-1 domain; Region: RF-1; pfam00472
220341005602	PS00745 Prokaryotic-type class I peptide chain release factors signature
220341005603	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
220341005604	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
220341005605	tRNA; other site
220341005606	putative tRNA binding site [nucleotide binding]; other site
220341005607	putative NADP binding site [chemical binding]; other site
220341005608	Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745
220341005609	PS00747 Glutamyl-tRNA reductase signature
220341005610	Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017
220341005611	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341005612	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
220341005613	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
220341005614	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
220341005615	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
220341005616	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
220341005617	active site
220341005618	PS00114 Phosphoribosyl pyrophosphate synthetase signature
220341005619	PS00103 Purine/pyrimidine phosphoribosyl transferases signature
220341005620	putative transporter; Provisional; Region: PRK11660
220341005621	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
220341005622	Sulfate transporter family; Region: Sulfate_transp; pfam00916
220341005623	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
220341005624	PS01130 Sulfate transporters signature
220341005625	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
220341005626	putative active site [active]
220341005627	catalytic residue [active]
220341005628	PS01196 Peptidyl-tRNA hydrolase signature 2
220341005629	GTP-binding protein YchF; Reviewed; Region: PRK09601
220341005630	YchF GTPase; Region: YchF; cd01900
220341005631	G1 box; other site
220341005632	GTP/Mg2+ binding site [chemical binding]; other site
220341005633	Switch I region; other site
220341005634	G2 box; other site
220341005635	Switch II region; other site
220341005636	G3 box; other site
220341005637	G4 box; other site
220341005638	G5 box; other site
220341005639	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
220341005640	PS00017 ATP/GTP-binding site motif A (P-loop)
220341005641	Protein of unknown function (DUF2743); Region: DUF2743; pfam10899
220341005642	Protein of unknown function (DUF4427); Region: DUF4427; pfam14468
220341005643	Pseudogene, hydrogenase-1 small subunit. Similar to Citrobacter freundii hydrogenase-1 small chain precursor hyaA SW:MBHS_CITFR (Q46045) (375 aa) fasta scores: E(): 0, 93.8% id in 192 aa, and to Escherichia coli hydrogenase-1 small chain precursor hyaA SW:MBHS_ECOLI (P19928) (372 aa) fasta scores: E(): 0, 91.1% id in 191 aa. Contains an in-frame stop at codon 167
220341005644	hydrogenase 1 large subunit; Provisional; Region: PRK10170
220341005645	PS00507 Nickel-dependent hydrogenases large subunit signature 1
220341005646	PS00508 Nickel-dependent hydrogenases large subunit signature 2
220341005647	hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171
220341005648	PS00883 Nickel-dependent hydrogenases b-type cytochrome subunit signature 2
220341005649	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
220341005650	putative substrate-binding site; other site
220341005651	nickel binding site [ion binding]; other site
220341005652	HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965
220341005653	HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809
220341005654	cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035
220341005655	cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028
220341005656	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
220341005657	PS00074 Glu / Leu / Phe / Val dehydrogenases active site
220341005658	'TREA_ECOLI (565 aa), 82% identity in 472 aa overlap. Contains an in-frame stop at codon 92. The sequence has been checked and is believed be correct'
220341005659	PS00927 Trehalase signature 1
220341005660	PS00928 Trehalase signature 2
220341005661	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
220341005662	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
220341005663	Flagellar regulator YcgR; Region: YcgR; pfam07317
220341005664	PilZ domain; Region: PilZ; pfam07238
220341005665	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
220341005666	N-acetyl-D-glucosamine binding site [chemical binding]; other site
220341005667	catalytic residue [active]
220341005668	PS00922 Prokaryotic transglycosylases signature
220341005669	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
220341005670	dimer interface [polypeptide binding]; other site
220341005671	catalytic triad [active]
220341005672	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
220341005673	NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263
220341005674	TrkA-C domain; Region: TrkA_C; pfam02080
220341005675	Transporter associated domain; Region: CorC_HlyC; smart01091
220341005676	alanine racemase; Reviewed; Region: dadX; PRK03646
220341005677	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
220341005678	active site
220341005679	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
220341005680	substrate binding site [chemical binding]; other site
220341005681	catalytic residues [active]
220341005682	dimer interface [polypeptide binding]; other site
220341005683	PS00395 Alanine racemase pyridoxal-phosphate attachment site
220341005684	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
220341005685	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
220341005686	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
220341005687	SpoVR family protein; Provisional; Region: PRK11767
220341005688	fatty acid metabolism regulator; Provisional; Region: PRK04984
220341005689	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
220341005690	DNA-binding site [nucleotide binding]; DNA binding site
220341005691	FadR C-terminal domain; Region: FadR_C; pfam07840
220341005692	PS00043 Bacterial regulatory proteins, gntR family signature
220341005693	sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547
220341005694	disulfide bond formation protein B; Provisional; Region: PRK01749
220341005695	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
220341005696	GnsA/GnsB family; Region: GnsAB; pfam08178
220341005697	hypothetical protein; Provisional; Region: PRK05170
220341005698	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
220341005699	hypothetical protein; Provisional; Region: PRK10691
220341005700	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100
220341005701	septum formation inhibitor; Reviewed; Region: minC; PRK03511
220341005702	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
220341005703	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
220341005704	cell division inhibitor MinD; Provisional; Region: PRK10818
220341005705	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
220341005706	P-loop; other site
220341005707	ADP binding residues [chemical binding]; other site
220341005708	Switch I; other site
220341005709	Switch II; other site
220341005710	PS00017 ATP/GTP-binding site motif A (P-loop)
220341005711	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
220341005712	ribonuclease D; Provisional; Region: PRK10829
220341005713	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
220341005714	catalytic site [active]
220341005715	putative active site [active]
220341005716	putative substrate binding site [chemical binding]; other site
220341005717	HRDC domain; Region: HRDC; cl02578
220341005718	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
220341005719	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
220341005720	acyl-activating enzyme (AAE) consensus motif; other site
220341005721	putative AMP binding site [chemical binding]; other site
220341005722	putative active site [active]
220341005723	putative CoA binding site [chemical binding]; other site
220341005724	PS00455 Putative AMP-binding domain signature
220341005725	PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature
220341005726	Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065
220341005727	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341005728	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
220341005729	Glycoprotease family; Region: Peptidase_M22; pfam00814
220341005730	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
220341005731	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708
220341005732	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
220341005733	PS00017 ATP/GTP-binding site motif A (P-loop)
220341005734	PS00017 ATP/GTP-binding site motif A (P-loop)
220341005735	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
220341005736	homotrimer interaction site [polypeptide binding]; other site
220341005737	putative active site [active]
220341005738	PS01094 Uncharacterized protein family UPF0076 signature
220341005739	hypothetical protein; Provisional; Region: PRK05114
220341005740	aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465
220341005741	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
220341005742	chorismate binding enzyme; Region: Chorismate_bind; cl10555
220341005743	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
220341005744	putative active site [active]
220341005745	putative CoA binding site [chemical binding]; other site
220341005746	nudix motif; other site
220341005747	metal binding site [ion binding]; metal-binding site
220341005748	L-serine deaminase; Provisional; Region: PRK15023
220341005749	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
220341005750	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
220341005751	phage resistance protein; Provisional; Region: PRK10551
220341005752	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
220341005753	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
220341005754	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
220341005755	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
220341005756	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
220341005757	Transporter associated domain; Region: CorC_HlyC; smart01091
220341005758	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
220341005759	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
220341005760	active pocket/dimerization site; other site
220341005761	active site
220341005762	phosphorylation site [posttranslational modification]
220341005763	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
220341005764	active site
220341005765	phosphorylation site [posttranslational modification]
220341005766	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
220341005767	PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103
220341005768	hypothetical protein; Provisional; Region: PRK02913
220341005769	hypothetical protein; Provisional; Region: PRK11469
220341005770	Domain of unknown function DUF; Region: DUF204; pfam02659
220341005771	Domain of unknown function DUF; Region: DUF204; pfam02659
220341005772	Methyltransferase domain; Region: Methyltransf_31; pfam13847
220341005773	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
220341005774	S-adenosylmethionine binding site [chemical binding]; other site
220341005775	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
220341005776	Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717
220341005777	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
220341005778	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
220341005779	DNA-binding site [nucleotide binding]; DNA binding site
220341005780	RNA-binding motif; other site
220341005781	PS00352 'Cold-shock' DNA-binding domain signature
220341005782	YebO-like protein; Region: YebO; pfam13974
220341005783	PhoPQ regulatory protein; Provisional; Region: PRK10299
220341005784	YobH-like protein; Region: YobH; pfam13996
220341005785	DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090
220341005786	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
220341005787	dimerization interface [polypeptide binding]; other site
220341005788	putative Zn2+ binding site [ion binding]; other site
220341005789	putative DNA binding site [nucleotide binding]; other site
220341005790	Bacterial transcriptional regulator; Region: IclR; pfam01614
220341005791	PS01051 Bacterial regulatory proteins, iclR family signature
220341005792	Pseudogene, possible integral membrane efflux protein. Similar to Escherichia coli o494 TR:P76269 (EMBL:AE000277) (494 aa) fasta scores: E(): 0, 89.5% id in 248 aa, and to Streptomyces coelicolor putative transmembrane efflux protein SC5G9.04C TR:Q9RL22 (EMBL:AL117385) (489 aa) fasta scores: E(): 2.1e-12, 28.3% id in 251 aa, and to Streptomyces glaucescens tetracenomycin C resistance and export protein tcmA SW:TCMA_STRGA (P39886) (538 aa) fasta scores: E(): 6.5e-11, 30.0% id in 220 aa. This CDS contains a frameshift after codon 8, and an inframe stop at codon 169
220341005793	heat shock protein HtpX; Provisional; Region: PRK05457
220341005794	carboxy-terminal protease; Provisional; Region: PRK11186
220341005795	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
220341005796	protein binding site [polypeptide binding]; other site
220341005797	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
220341005798	Catalytic dyad [active]
220341005799	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
220341005800	ProP expression regulator; Provisional; Region: PRK04950
220341005801	putative RNA binding sites [nucleotide binding]; other site
220341005802	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
220341005803	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
220341005804	Paraquat-inducible protein A; Region: PqiA; pfam04403
220341005805	Paraquat-inducible protein A; Region: PqiA; pfam04403
220341005806	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
220341005807	mce related protein; Region: MCE; pfam02470
220341005808	mce related protein; Region: MCE; pfam02470
220341005809	mce related protein; Region: MCE; pfam02470
220341005810	mce related protein; Region: MCE; pfam02470
220341005811	mce related protein; Region: MCE; pfam02470
220341005812	mce related protein; Region: MCE; pfam02470
220341005813	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
220341005814	Methyltransferase domain; Region: Methyltransf_26; pfam13659
220341005815	Uncharacterized conserved protein [Function unknown]; Region: COG3270
220341005816	Protein of unknown function (DUF1480); Region: DUF1480; pfam07351
220341005817	Protein of unknown function (DUF1482); Region: DUF1482; pfam07358
220341005818	serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439
220341005819	PS00125 Serine/threonine specific protein phosphatases signature
220341005820	Pseudogene, possible invasion-associated secreted protein. Similar to Salmonella typhimurium invasion-associated secreted protein SopE2 TR:AAF63159 (240 aa) fasta scores: E(): 0, 98.7% id in 154 aa, and to Salmonella typhi SopE sopE TR:Q9RPM6 (EMBL:AF153829) (240 aa) fasta scores: E(): 0, 73.5% id in 151 aa. This CDS contains a frameshift after codon 24. The sequence has been checked and is believed to be correct
220341005821	Protein of unknown function (DUF1398); Region: DUF1398; cl11576
220341005822	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
220341005823	Coenzyme A binding pocket [chemical binding]; other site
220341005824	Pseudogene, transposase. Similar to Yersinia pestis transposase y1062 or ypmt1.80C TR:O68779 (EMBL:AF053947) (402 aa) fasta scores: E(): 0, 86.8% id in 318 aa. This CDS contains an in-frame stop at codon 78. The sequence has been checked and is believed to be correct
220341005825	PS01007 Transposases, Mutator family, signature
220341005826	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
220341005827	EamA-like transporter family; Region: EamA; pfam00892
220341005828	EamA-like transporter family; Region: EamA; pfam00892
220341005829	Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495
220341005830	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
220341005831	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
220341005832	Alkyl sulfatase dimerization; Region: Alkyl_sulf_dimr; pfam14863
220341005833	Alkyl sulfatase C-terminal; Region: Alkyl_sulf_C; pfam14864
220341005834	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176
220341005835	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
220341005836	metal binding site [ion binding]; metal-binding site
220341005837	active site
220341005838	I-site; other site
220341005839	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
220341005840	long tail fiber, proximal subunit; Provisional; Region: 34; PHA02584
220341005841	Phage-related tail fibre protein [General function prediction only]; Region: COG5301
220341005842	Protein of unknown function (DUF2612); Region: DUF2612; pfam11041
220341005843	Baseplate J-like protein; Region: Baseplate_J; cl01294
220341005844	PS00017 ATP/GTP-binding site motif A (P-loop)
220341005845	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
220341005846	Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812
220341005847	HEPN domain; Region: HEPN; cl00824
220341005848	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050
220341005849	virion protein; Provisional; Region: V; PHA02564
220341005850	Protein of unknown function (DUF3277); Region: DUF3277; pfam11681
220341005851	Protein of unknown function (DUF3383); Region: DUF3383; pfam11863
220341005852	Protein of unknown function (DUF4054); Region: DUF4054; pfam13262
220341005853	Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950
220341005854	PS00017 ATP/GTP-binding site motif A (P-loop)
220341005855	Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979
220341005856	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
220341005857	Protein of unknown function (DUF1073); Region: DUF1073; pfam06381
220341005858	Phage terminase large subunit; Region: Terminase_3; cl12054
220341005859	The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes.  But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736
220341005860	N-acetyl-D-glucosamine binding site [chemical binding]; other site
220341005861	catalytic residue [active]
220341005862	phage holin, lambda family; Region: holin_lambda; TIGR01594
220341005863	ORF6N domain; Region: ORF6N; pfam10543
220341005864	Protein of unknown function (DUF1133); Region: DUF1133; pfam06576
220341005865	Protein of unknown function (DUF1364); Region: DUF1364; pfam07102
220341005866	PS00190 Cytochrome c family heme-binding site signature
220341005867	Protein of unknown function (DUF1367); Region: DUF1367; pfam07105
220341005868	Hok/gef family; Region: HOK_GEF; pfam01848
220341005869	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
220341005870	Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163
220341005871	Protein of unknown function (DUF1627); Region: DUF1627; pfam07789
220341005872	putative replication protein; Provisional; Region: PRK12377
220341005873	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
220341005874	Walker A motif; other site
220341005875	ATP binding site [chemical binding]; other site
220341005876	Walker B motif; other site
220341005877	arginine finger; other site
220341005878	Protein of unknown function (DUF1019); Region: DUF1019; pfam06254
220341005879	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
220341005880	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
220341005881	non-specific DNA binding site [nucleotide binding]; other site
220341005882	salt bridge; other site
220341005883	sequence-specific DNA binding site [nucleotide binding]; other site
220341005884	transcriptional repressor DicA; Reviewed; Region: PRK09706
220341005885	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
220341005886	non-specific DNA binding site [nucleotide binding]; other site
220341005887	salt bridge; other site
220341005888	sequence-specific DNA binding site [nucleotide binding]; other site
220341005889	FtsZ inhibitor protein; Reviewed; Region: kil; PRK11354
220341005890	hypothetical protein; Reviewed; Region: PRK09790
220341005891	exonuclease VIII; Reviewed; Region: PRK09709
220341005892	Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630
220341005893	RecT family; Region: RecT; pfam03837
220341005894	restriction alleviation and modification protein; Reviewed; Region: lar; PRK09710
220341005895	Excisionase-like protein; Region: Exc; pfam07825
220341005896	Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003
220341005897	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
220341005898	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
220341005899	Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome.  They belong to the superfamily...; Region: INT_Lambda_C; cd00800
220341005900	dimer interface [polypeptide binding]; other site
220341005901	active site
220341005902	Int/Topo IB signature motif; other site
220341005903	Protein of unknown function (DUF2511); Region: DUF2511; pfam10709
220341005904	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
220341005905	hypothetical protein; Provisional; Region: PRK10301
220341005906	DNA polymerase III subunit theta; Reviewed; Region: PRK10969
220341005907	Predicted amidohydrolase [General function prediction only]; Region: COG0388
220341005908	exodeoxyribonuclease X; Provisional; Region: PRK07983
220341005909	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
220341005910	active site
220341005911	catalytic site [active]
220341005912	substrate binding site [chemical binding]; other site
220341005913	protease 2; Provisional; Region: PRK10115
220341005914	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
220341005915	PS00708 Prolyl endopeptidase family serine active site
220341005916	Protein of unknown function (DUF533); Region: DUF533; pfam04391
220341005917	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
220341005918	putative metal binding site [ion binding]; other site
220341005919	hypothetical protein; Provisional; Region: PRK13680
220341005920	DNA damage-inducible protein YebG; Provisional; Region: PRK10061
220341005921	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
220341005922	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
220341005923	ATP-grasp domain; Region: ATP-grasp; pfam02222
220341005924	Entner-Doudoroff aldolase; Region: eda; TIGR01182
220341005925	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
220341005926	active site
220341005927	intersubunit interface [polypeptide binding]; other site
220341005928	catalytic residue [active]
220341005930	PS00160 KDPG and KHG aldolases Schiff-base forming residue
220341005931	PS00159 KDPG and KHG aldolases active site
220341005932	phosphogluconate dehydratase; Validated; Region: PRK09054
220341005933	PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 2
220341005934	PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1
220341005935	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
220341005936	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
220341005937	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
220341005938	PS00069 Glucose-6-phosphate dehydrogenase active site
220341005939	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
220341005940	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
220341005941	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
220341005942	putative active site [active]
220341005943	pyruvate kinase; Provisional; Region: PRK05826
220341005944	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
220341005945	domain interfaces; other site
220341005946	active site
220341005947	PS00110 Pyruvate kinase active site signature
220341005948	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
220341005949	putative acyl-acceptor binding pocket; other site
220341005950	putative peptidase; Provisional; Region: PRK11649
220341005951	Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525
220341005952	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
220341005953	Peptidase family M23; Region: Peptidase_M23; pfam01551
220341005954	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
220341005955	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
220341005956	metal binding site [ion binding]; metal-binding site
220341005957	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
220341005958	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
220341005959	PS00017 ATP/GTP-binding site motif A (P-loop)
220341005960	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
220341005961	ABC-ATPase subunit  interface; other site
220341005962	dimer interface [polypeptide binding]; other site
220341005963	putative PBP binding regions; other site
220341005964	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341005965	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
220341005966	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
220341005967	Walker A motif; other site
220341005968	ATP binding site [chemical binding]; other site
220341005969	Walker B motif; other site
220341005970	arginine finger; other site
220341005971	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
220341005972	PS00017 ATP/GTP-binding site motif A (P-loop)
220341005973	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
220341005974	RuvA N terminal domain; Region: RuvA_N; pfam01330
220341005975	Helix-hairpin-helix domain; Region: HHH_5; pfam14520
220341005976	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
220341005977	hypothetical protein; Provisional; Region: PRK11470
220341005978	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
220341005979	active site
220341005980	putative DNA-binding cleft [nucleotide binding]; other site
220341005981	dimer interface [polypeptide binding]; other site
220341005982	PS01321 Crossover junction endodeoxyribonuclease ruvC signature
220341005983	hypothetical protein; Validated; Region: PRK00110
220341005984	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
220341005985	nudix motif; other site
220341005986	PS00893 mutT domain signature
220341005987	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
220341005988	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
220341005989	dimer interface [polypeptide binding]; other site
220341005990	anticodon binding site; other site
220341005991	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
220341005992	homodimer interface [polypeptide binding]; other site
220341005993	motif 1; other site
220341005994	active site
220341005995	motif 2; other site
220341005996	GAD domain; Region: GAD; pfam02938
220341005997	motif 3; other site
220341005998	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2
220341005999	PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1
220341006000	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
220341006001	catalytic triad [active]
220341006002	conserved cis-peptide bond; other site
220341006003	hypothetical protein; Provisional; Region: PRK10302
220341006004	Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788
220341006005	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
220341006006	S-adenosylmethionine binding site [chemical binding]; other site
220341006007	tRNA (mo5U34)-methyltransferase; Region: TIGR00452
220341006008	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
220341006009	S-adenosylmethionine binding site [chemical binding]; other site
220341006010	copper homeostasis protein CutC; Provisional; Region: PRK11572
220341006011	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268
220341006012	putative metal binding site [ion binding]; other site
220341006013	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
220341006014	arginyl-tRNA synthetase; Region: argS; TIGR00456
220341006015	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
220341006016	active site
220341006017	HIGH motif; other site
220341006018	KMSK motif region; other site
220341006019	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
220341006020	tRNA binding surface [nucleotide binding]; other site
220341006021	anticodon binding site; other site
220341006022	PS00178 Aminoacyl-transfer RNA synthetases class-I signature
220341006023	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
220341006024	Flagellar protein FlhE; Region: FlhE; pfam06366
220341006025	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
220341006026	PS00994 Bacterial export FHIPEP family signature
220341006027	FlhB HrpN YscU SpaS Family; Region: Bac_export_2; cl19167
220341006028	PS00017 ATP/GTP-binding site motif A (P-loop)
220341006029	chemotaxis regulator CheZ; Provisional; Region: PRK11166
220341006030	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
220341006031	active site
220341006032	phosphorylation site [posttranslational modification]
220341006033	intermolecular recognition site; other site
220341006034	dimerization interface [polypeptide binding]; other site
220341006035	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
220341006036	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
220341006037	active site
220341006038	phosphorylation site [posttranslational modification]
220341006039	intermolecular recognition site; other site
220341006040	dimerization interface [polypeptide binding]; other site
220341006041	CheB methylesterase; Region: CheB_methylest; pfam01339
220341006042	chemotaxis methyltransferase CheR; Provisional; Region: PRK10611
220341006043	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
220341006044	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
220341006045	S-adenosylmethionine binding site [chemical binding]; other site
220341006046	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
220341006047	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
220341006048	dimer interface [polypeptide binding]; other site
220341006049	ligand binding site [chemical binding]; other site
220341006050	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
220341006051	dimerization interface [polypeptide binding]; other site
220341006052	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
220341006053	dimer interface [polypeptide binding]; other site
220341006054	putative CheW interface [polypeptide binding]; other site
220341006055	PS00538 Bacterial chemotaxis sensory transducers signature
220341006056	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
220341006057	putative CheA interaction surface; other site
220341006058	chemotaxis protein CheA; Provisional; Region: PRK10547
220341006059	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
220341006060	putative binding surface; other site
220341006061	active site
220341006062	CheY binding; Region: CheY-binding; pfam09078
220341006063	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
220341006064	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
220341006065	ATP binding site [chemical binding]; other site
220341006066	Mg2+ binding site [ion binding]; other site
220341006067	G-X-G motif; other site
220341006068	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
220341006069	flagellar motor protein MotB; Validated; Region: motB; PRK09041
220341006070	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
220341006071	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
220341006072	ligand binding site [chemical binding]; other site
220341006073	flagellar motor protein MotA; Validated; Region: PRK09110
220341006074	PS01307 Flagellar motor protein motA family signature
220341006075	transcriptional activator FlhC; Provisional; Region: PRK12722
220341006076	transcriptional activator FlhD; Provisional; Region: PRK02909
220341006077	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
220341006078	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
220341006079	active site
220341006080	homotetramer interface [polypeptide binding]; other site
220341006081	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
220341006082	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
220341006083	active site
220341006084	motif I; other site
220341006085	motif II; other site
220341006086	DJ-1 family protein; Region: not_thiJ; TIGR01383
220341006087	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
220341006088	conserved cys residue [active]
220341006089	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
220341006090	Ferritin-like domain; Region: Ferritin; pfam00210
220341006091	ferroxidase diiron center [ion binding]; other site
220341006092	YecR-like lipoprotein; Region: YecR; pfam13992
220341006093	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341006094	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
220341006095	Ferritin-like domain; Region: Ferritin; pfam00210
220341006096	ferroxidase diiron center [ion binding]; other site
220341006097	probable metal-binding protein; Region: matur_matur; TIGR03853
220341006098	tyrosine transporter TyrP; Provisional; Region: PRK15132
220341006099	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
220341006100	PS00594 Aromatic amino acids permeases signature
220341006101	hypothetical protein; Provisional; Region: PRK10396
220341006102	yecA family protein; Region: ygfB_yecA; TIGR02292
220341006103	SEC-C motif; Region: SEC-C; pfam02810
220341006104	SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913
220341006105	SH3 domain of SH3b2 type; Region: SH3_7; pfam12914
220341006106	NlpC/P60 family; Region: NLPC_P60; cl17555
220341006107	phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832
220341006108	PS00379 CDP-alcohol phosphatidyltransferases signature
220341006109	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
220341006110	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
220341006111	GIY-YIG motif/motif A; other site
220341006112	active site
220341006113	catalytic site [active]
220341006114	putative DNA binding site [nucleotide binding]; other site
220341006115	metal binding site [ion binding]; metal-binding site
220341006116	UvrB/uvrC motif; Region: UVR; pfam02151
220341006117	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
220341006118	Helix-hairpin-helix domain; Region: HHH_5; pfam14520
220341006119	response regulator; Provisional; Region: PRK09483
220341006120	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
220341006121	active site
220341006122	phosphorylation site [posttranslational modification]
220341006123	intermolecular recognition site; other site
220341006124	dimerization interface [polypeptide binding]; other site
220341006125	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
220341006126	DNA binding residues [nucleotide binding]
220341006127	dimerization interface [polypeptide binding]; other site
220341006128	PS00622 Bacterial regulatory proteins, luxR family signature
220341006129	hypothetical protein; Provisional; Region: PRK10613
220341006130	DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188
220341006131	Autoinducer binding domain; Region: Autoind_bind; pfam03472
220341006132	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
220341006133	DNA binding residues [nucleotide binding]
220341006134	dimerization interface [polypeptide binding]; other site
220341006135	PS00622 Bacterial regulatory proteins, luxR family signature
220341006136	putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264
220341006137	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
220341006138	Walker A/P-loop; other site
220341006139	ATP binding site [chemical binding]; other site
220341006140	Q-loop/lid; other site
220341006141	ABC transporter signature motif; other site
220341006142	Walker B; other site
220341006143	D-loop; other site
220341006144	H-loop/switch region; other site
220341006145	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
220341006146	PS00211 ABC transporters family signature
220341006147	PS00017 ATP/GTP-binding site motif A (P-loop)
220341006148	amino acid ABC transporter permease; Provisional; Region: PRK15100
220341006149	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341006150	dimer interface [polypeptide binding]; other site
220341006151	conserved gate region; other site
220341006152	putative PBP binding loops; other site
220341006153	ABC-ATPase subunit interface; other site
220341006154	PS00402 Binding-protein-dependent transport systems inner membrane comp sign
220341006155	Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449
220341006156	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341006157	catalytic residue [active]
220341006158	cystine transporter subunit; Provisional; Region: PRK11260
220341006159	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
220341006160	substrate binding pocket [chemical binding]; other site
220341006161	membrane-bound complex binding site; other site
220341006162	hinge residues; other site
220341006163	PS01039 Bacterial extracellular solute-binding proteins, family 3 signature
220341006164	flagella biosynthesis protein FliZ; Provisional; Region: PRK11582
220341006165	PS00190 Cytochrome c family heme-binding site signature
220341006166	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
220341006167	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
220341006168	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
220341006169	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
220341006170	DNA binding residues [nucleotide binding]
220341006171	PS00716 Sigma-70 factors family signature 2
220341006172	PS00715 Sigma-70 factors family signature 1
220341006173	flagellin; Validated; Region: PRK08026
220341006174	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
220341006175	Flagellin D3 domain; Region: Flagellin_D3; pfam08884
220341006176	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
220341006177	flagellar capping protein; Reviewed; Region: fliD; PRK08032
220341006178	Flagellar hook-associated protein 2 N-terminus; Region: FliD_N; pfam02465
220341006179	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
220341006180	flagellar protein FliS; Validated; Region: fliS; PRK05685
220341006181	flagellar biosynthesis protein FliT; Provisional; Region: PRK10548
220341006182	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
220341006183	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
220341006184	active site
220341006185	Na/Ca binding site [ion binding]; other site
220341006186	catalytic site [active]
220341006187	lipoprotein; Provisional; Region: PRK10397
220341006188	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341006189	putative inner membrane protein; Provisional; Region: PRK11099
220341006190	Predicted transporter component [General function prediction only]; Region: COG2391
220341006191	YedF is a bacterial SirA-like protein of unknown function.  SirA  (also known as UvrY,  and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422
220341006192	CPxP  motif; other site
220341006193	PS01148 Uncharacterized protein family UPF0033 signature
220341006194	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253
220341006195	flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206
220341006196	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
220341006197	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
220341006198	flagellar motor switch protein FliG; Region: fliG; TIGR00207
220341006199	FliG N-terminal domain; Region: FliG_N; pfam14842
220341006200	FliG middle domain; Region: FliG_M; pfam14841
220341006201	FliG C-terminal domain; Region: FliG_C; pfam01706
220341006202	flagellar assembly protein H; Validated; Region: fliH; PRK05687
220341006203	Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811
220341006204	Flagellar assembly protein FliH; Region: FliH; pfam02108
220341006205	flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960
220341006206	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
220341006207	Walker A motif/ATP binding site; other site
220341006208	Walker B motif; other site
220341006209	PS00017 ATP/GTP-binding site motif A (P-loop)
220341006210	PS00152 ATP synthase alpha and beta subunits signature
220341006211	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
220341006212	flagellar hook-length control protein; Provisional; Region: PRK10118
220341006213	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
220341006214	PS00017 ATP/GTP-binding site motif A (P-loop)
220341006215	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021
220341006216	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341006217	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
220341006218	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
220341006219	flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963
220341006220	flagellar biosynthesis protein FliO; Provisional; Region: PRK11486
220341006221	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
220341006222	PS01060 Flagella transport protein fliP family signature 1
220341006223	PS01061 Flagella transport protein fliP family signature 2
220341006224	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
220341006225	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
220341006226	colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411
220341006227	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
220341006228	DNA binding residues [nucleotide binding]
220341006229	dimerization interface [polypeptide binding]; other site
220341006230	PS00622 Bacterial regulatory proteins, luxR family signature
220341006231	hypothetical protein; Provisional; Region: PRK10708
220341006232	Protein of unknown function (DUF2525); Region: DUF2525; pfam10733
220341006233	mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669
220341006234	mannosyl-3-phosphoglycerate phosphatase family; Region: HAD-SF-IIB-MPGP; TIGR01486
220341006235	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
220341006236	active site
220341006237	motif I; other site
220341006238	motif II; other site
220341006239	putative diguanylate cyclase YedQ; Provisional; Region: PRK15426
220341006240	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
220341006241	metal binding site [ion binding]; metal-binding site
220341006242	active site
220341006243	I-site; other site
220341006244	Uncharacterized small protein [Function unknown]; Region: COG5475
220341006245	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
220341006246	EamA-like transporter family; Region: EamA; pfam00892
220341006247	EamA-like transporter family; Region: EamA; pfam00892
220341006248	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
220341006249	additional DNA contacts [nucleotide binding]; other site
220341006250	mismatch recognition site; other site
220341006251	active site
220341006252	zinc binding site [ion binding]; other site
220341006253	DNA intercalation site [nucleotide binding]; other site
220341006254	DNA cytosine methylase; Provisional; Region: PRK10458
220341006255	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
220341006256	cofactor binding site; other site
220341006257	DNA binding site [nucleotide binding]
220341006258	substrate interaction site [chemical binding]; other site
220341006259	PS00095 C-5 cytosine-specific DNA methylases C-terminal signature
220341006260	PS00094 C-5 cytosine-specific DNA methylases active site
220341006261	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
220341006262	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
220341006263	Zn2+ binding site [ion binding]; other site
220341006264	Mg2+ binding site [ion binding]; other site
220341006265	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
220341006266	trimer interface [polypeptide binding]; other site
220341006267	eyelet of channel; other site
220341006268	PS00576 General diffusion Gram-negative porins signature
220341006269	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
220341006270	DNA-binding site [nucleotide binding]; DNA binding site
220341006271	RNA-binding motif; other site
220341006272	PS00352 'Cold-shock' DNA-binding domain signature
220341006273	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
220341006274	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
220341006275	active site
220341006276	DNA binding site [nucleotide binding]
220341006277	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
220341006278	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
220341006279	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
220341006280	Catalytic site [active]
220341006281	DgsA anti-repressor MtfA; Provisional; Region: PRK15410
220341006282	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature
220341006283	AMP nucleosidase; Provisional; Region: PRK08292
220341006284	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
220341006285	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
220341006286	Protein of unknown function (DUF1493); Region: DUF1493; pfam07377
220341006287	MATE family multidrug exporter; Provisional; Region: PRK10189
220341006288	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
220341006289	L,D-transpeptidase; Provisional; Region: PRK10190
220341006290	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
220341006291	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
220341006292	putative dimer interface [polypeptide binding]; other site
220341006293	active site pocket [active]
220341006294	putative cataytic base [active]
220341006295	cobalamin synthase; Reviewed; Region: cobS; PRK00235
220341006296	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
220341006297	homotrimer interface [polypeptide binding]; other site
220341006298	Walker A motif; other site
220341006299	GTP binding site [chemical binding]; other site
220341006300	Walker B motif; other site
220341006301	PS00017 ATP/GTP-binding site motif A (P-loop)
220341006302	cobyric acid synthase; Provisional; Region: PRK00784
220341006303	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
220341006304	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
220341006305	catalytic triad [active]
220341006306	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638
220341006307	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
220341006308	Walker A/P-loop; other site
220341006309	ATP binding site [chemical binding]; other site
220341006310	Q-loop/lid; other site
220341006311	ABC transporter signature motif; other site
220341006312	Walker B; other site
220341006313	D-loop; other site
220341006314	H-loop/switch region; other site
220341006315	PS00211 ABC transporters family signature
220341006316	PS00017 ATP/GTP-binding site motif A (P-loop)
220341006317	cobalt transport protein CbiQ; Provisional; Region: PRK15485
220341006318	cobalt transport protein CbiN; Provisional; Region: PRK02898
220341006319	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
220341006320	active site
220341006321	SAM binding site [chemical binding]; other site
220341006322	homodimer interface [polypeptide binding]; other site
220341006323	PS00840 Uroporphyrin-III C-methyltransferase signature 2
220341006324	PS00839 Uroporphyrin-III C-methyltransferase signature 1
220341006325	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
220341006326	active site
220341006327	SAM binding site [chemical binding]; other site
220341006328	homodimer interface [polypeptide binding]; other site
220341006329	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
220341006330	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
220341006331	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
220341006332	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
220341006333	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
220341006334	active site
220341006335	SAM binding site [chemical binding]; other site
220341006336	homodimer interface [polypeptide binding]; other site
220341006337	PS00840 Uroporphyrin-III C-methyltransferase signature 2
220341006338	PS00017 ATP/GTP-binding site motif A (P-loop)
220341006339	PS00839 Uroporphyrin-III C-methyltransferase signature 1
220341006340	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
220341006341	S-adenosylmethionine binding site [chemical binding]; other site
220341006342	PS00012 Phosphopantetheine attachment site
220341006343	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
220341006344	active site
220341006345	putative homodimer interface [polypeptide binding]; other site
220341006346	SAM binding site [chemical binding]; other site
220341006347	Cobalamin biosynthesis protein CbiD [Coenzyme metabolism]; Region: CbiD; COG1903
220341006349	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
220341006350	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
220341006351	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
220341006352	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
220341006353	catalytic triad [active]
220341006354	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
220341006355	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341006356	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
220341006357	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341006358	PS00041 Bacterial regulatory proteins, araC family signature
220341006359	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
220341006360	amphipathic channel; other site
220341006361	Asn-Pro-Ala signature motifs; other site
220341006362	PS00221 MIP family signature
220341006363	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
220341006364	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
220341006365	Hexamer interface [polypeptide binding]; other site
220341006366	Hexagonal pore residue; other site
220341006367	PS01139 Bacterial microcompartiments proteins signature
220341006368	Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutL; COG4816
220341006369	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047
220341006370	putative hexamer interface [polypeptide binding]; other site
220341006371	putative hexagonal pore; other site
220341006372	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048
220341006373	putative hexamer interface [polypeptide binding]; other site
220341006374	putative hexagonal pore; other site
220341006375	Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687
220341006376	alpha-alpha subunit/dimer interface [polypeptide binding]; other site
220341006377	alpha-beta subunit interface [polypeptide binding]; other site
220341006378	alpha-gamma subunit interface [polypeptide binding]; other site
220341006379	active site
220341006380	substrate and K+ binding site; other site
220341006381	K+ binding site [ion binding]; other site
220341006382	cobalamin binding site [chemical binding]; other site
220341006383	propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042
220341006384	Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910
220341006385	Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841
220341006386	Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288
220341006387	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
220341006388	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
220341006389	Hexamer interface [polypeptide binding]; other site
220341006390	Hexagonal pore residue; other site
220341006391	PS01139 Bacterial microcompartiments proteins signature
220341006392	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
220341006393	1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056
220341006394	putative hexamer interface [polypeptide binding]; other site
220341006395	putative hexagonal pore; other site
220341006396	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
220341006397	Propanediol utilisation protein PduL; Region: PduL; pfam06130
220341006398	Propanediol utilisation protein PduL; Region: PduL; pfam06130
220341006399	putative propanediol utilization protein PduM; Provisional; Region: PRK15428
220341006400	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
220341006401	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
220341006402	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
220341006403	putative catalytic cysteine [active]
220341006404	1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180
220341006405	putative active site [active]
220341006406	metal binding site [ion binding]; metal-binding site
220341006407	PS00913 Iron-containing alcohol dehydrogenases signature 1
220341006408	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
220341006409	SLBB domain; Region: SLBB; pfam10531
220341006410	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
220341006411	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
220341006412	RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375
220341006413	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341006414	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
220341006415	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
220341006416	putative hexamer interface [polypeptide binding]; other site
220341006417	putative hexagonal pore; other site
220341006418	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
220341006419	putative hexamer interface [polypeptide binding]; other site
220341006420	putative hexagonal pore; other site
220341006421	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
220341006422	putative hexamer interface [polypeptide binding]; other site
220341006423	putative hexagonal pore; other site
220341006424	Ethanolamine utilisation - propanediol utilisation; Region: PduV-EutP; pfam10662
220341006425	G3 box; other site
220341006426	Switch II region; other site
220341006427	GTP/Mg2+ binding site [chemical binding]; other site
220341006428	G4 box; other site
220341006429	G5 box; other site
220341006430	PS00017 ATP/GTP-binding site motif A (P-loop)
220341006431	propionate kinase; Reviewed; Region: PRK12397
220341006432	PS01075 Acetate and butyrate kinases family signature 1
220341006433	PS01076 Acetate and butyrate kinases family signature 2
220341006434	Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542
220341006435	hypothetical protein; Provisional; Region: PRK05423
220341006436	Predicted membrane protein [Function unknown]; Region: COG1289
220341006437	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
220341006438	DNA gyrase inhibitor; Provisional; Region: PRK10016
220341006439	' Fasta hit to DACD_ECOLI (388 aa), 88% identity in 315 aa overlap. Contains stop codon at codon 318. The sequence has been checked and is believed to be correct'
220341006440	thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006
220341006441	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
220341006442	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
220341006443	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
220341006444	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341006445	thiosulfate reductase PhsA; Provisional; Region: PRK15488
220341006446	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
220341006447	The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755
220341006448	putative [Fe4-S4] binding site [ion binding]; other site
220341006449	putative molybdopterin cofactor binding site [chemical binding]; other site
220341006450	The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778
220341006451	putative molybdopterin cofactor binding site; other site
220341006452	PS00932 Prokaryotic molybdopterin oxidoreductases signature 3
220341006453	PS00490 Prokaryotic molybdopterin oxidoreductases signature 2
220341006454	PS00551 Prokaryotic molybdopterin oxidoreductases signature 1
220341006455	exonuclease I; Provisional; Region: sbcB; PRK11779
220341006456	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
220341006457	active site
220341006458	catalytic site [active]
220341006459	substrate binding site [chemical binding]; other site
220341006460	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
220341006461	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
220341006462	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
220341006463	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341006464	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
220341006465	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
220341006466	dimerization interface [polypeptide binding]; other site
220341006467	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
220341006468	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
220341006469	putative NAD(P) binding site [chemical binding]; other site
220341006470	PS00017 ATP/GTP-binding site motif A (P-loop)
220341006471	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
220341006472	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
220341006473	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
220341006474	PS01316 ATP phosphoribosyltransferase signature
220341006475	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
220341006476	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
220341006477	NAD binding site [chemical binding]; other site
220341006478	dimerization interface [polypeptide binding]; other site
220341006479	product binding site; other site
220341006480	substrate binding site [chemical binding]; other site
220341006481	zinc binding site [ion binding]; other site
220341006482	catalytic residues [active]
220341006483	PS00611 Histidinol dehydrogenase signature
220341006484	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
220341006485	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
220341006486	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341006487	homodimer interface [polypeptide binding]; other site
220341006488	catalytic residue [active]
220341006489	PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site
220341006490	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
220341006491	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
220341006492	active site
220341006493	motif I; other site
220341006494	motif II; other site
220341006495	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
220341006496	putative active site pocket [active]
220341006497	4-fold oligomerization interface [polypeptide binding]; other site
220341006498	metal binding residues [ion binding]; metal-binding site
220341006499	3-fold/trimer interface [polypeptide binding]; other site
220341006500	PS00954 Imidazoleglycerol-phosphate dehydratase signature 1
220341006501	PS00955 Imidazoleglycerol-phosphate dehydratase signature 2
220341006502	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142
220341006503	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
220341006504	putative active site [active]
220341006505	oxyanion strand; other site
220341006506	catalytic triad [active]
220341006507	PS00442 Glutamine amidotransferases class-I active site
220341006508	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
220341006509	catalytic residues [active]
220341006510	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
220341006511	substrate binding site [chemical binding]; other site
220341006512	glutamase interaction surface [polypeptide binding]; other site
220341006513	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
220341006514	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
220341006515	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
220341006516	metal binding site [ion binding]; metal-binding site
220341006517	chain length determinant protein WzzB; Provisional; Region: PRK15471
220341006518	Chain length determinant protein; Region: Wzz; pfam02706
220341006519	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
220341006520	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
220341006521	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126
220341006522	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
220341006523	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
220341006524	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
220341006525	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
220341006526	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
220341006527	PS00461 6-phosphogluconate dehydrogenase signature
220341006528	capsular polysaccharide biosynthetic cluster (insertion relative to Escherichia coli). Base composition 37.8 % G+C
220341006529	undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204
220341006530	CoA binding domain; Region: CoA_binding; cl17356
220341006531	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
220341006532	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341006533	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
220341006534	ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088
220341006535	active site
220341006536	substrate binding site [chemical binding]; other site
220341006537	metal binding site [ion binding]; metal-binding site
220341006538	PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature
220341006539	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
220341006540	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
220341006541	Substrate binding site; other site
220341006542	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
220341006543	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
220341006544	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
220341006545	active site
220341006546	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
220341006547	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
220341006548	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
220341006549	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
220341006550	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
220341006551	active site
220341006552	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
220341006553	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082
220341006554	CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258
220341006555	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
220341006556	NAD binding site [chemical binding]; other site
220341006557	homotetramer interface [polypeptide binding]; other site
220341006558	homodimer interface [polypeptide binding]; other site
220341006559	active site
220341006560	substrate binding site [chemical binding]; other site
220341006561	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
220341006562	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
220341006563	NAD(P) binding site [chemical binding]; other site
220341006564	active site
220341006565	lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407
220341006566	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
220341006567	inhibitor-cofactor binding pocket; inhibition site
220341006568	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341006569	catalytic residue [active]
220341006570	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
220341006571	CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252
220341006572	NAD binding site [chemical binding]; other site
220341006573	homotetramer interface [polypeptide binding]; other site
220341006574	homodimer interface [polypeptide binding]; other site
220341006575	substrate binding site [chemical binding]; other site
220341006576	active site
220341006577	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
220341006578	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
220341006579	substrate binding site; other site
220341006580	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
220341006581	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
220341006582	catalytic loop [active]
220341006583	iron binding site [ion binding]; other site
220341006584	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
220341006585	FAD binding pocket [chemical binding]; other site
220341006586	FAD binding motif [chemical binding]; other site
220341006587	phosphate binding motif [ion binding]; other site
220341006588	beta-alpha-beta structure motif; other site
220341006589	NAD binding pocket [chemical binding]; other site
220341006590	PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature
220341006591	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
220341006592	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
220341006593	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
220341006594	substrate binding site; other site
220341006595	tetramer interface; other site
220341006596	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
220341006597	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
220341006598	NADP binding site [chemical binding]; other site
220341006599	active site
220341006600	putative substrate binding site [chemical binding]; other site
220341006601	dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084
220341006602	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
220341006603	NAD binding site [chemical binding]; other site
220341006604	substrate binding site [chemical binding]; other site
220341006605	homodimer interface [polypeptide binding]; other site
220341006606	active site
220341006607	PS00061 Short-chain dehydrogenases/reductases family signature
220341006608	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
220341006609	active site
220341006610	tetramer interface; other site
220341006611	colanic acid biosynthesis protein WcaM; Region: WcaM; TIGR04004
220341006612	colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427
220341006613	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
220341006614	putative ADP-binding pocket [chemical binding]; other site
220341006615	colanic acid exporter; Provisional; Region: PRK10459
220341006616	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
220341006617	putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124
220341006618	CoA-binding domain; Region: CoA_binding_3; pfam13727
220341006619	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
220341006620	phosphomannomutase CpsG; Provisional; Region: PRK15414
220341006621	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
220341006622	active site
220341006623	substrate binding site [chemical binding]; other site
220341006624	metal binding site [ion binding]; metal-binding site
220341006625	PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature
220341006626	mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460
220341006627	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
220341006628	Substrate binding site; other site
220341006629	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
220341006630	colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007
220341006631	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
220341006632	GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430
220341006633	active site
220341006634	GDP-Mannose binding site [chemical binding]; other site
220341006635	dimer interface [polypeptide binding]; other site
220341006636	modified nudix motif
220341006637	metal binding site [ion binding]; metal-binding site
220341006638	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
220341006639	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
220341006640	NADP binding site [chemical binding]; other site
220341006641	active site
220341006642	putative substrate binding site [chemical binding]; other site
220341006643	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
220341006644	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
220341006645	NADP-binding site; other site
220341006646	homotetramer interface [polypeptide binding]; other site
220341006647	substrate binding site [chemical binding]; other site
220341006648	homodimer interface [polypeptide binding]; other site
220341006649	active site
220341006650	PS00061 Short-chain dehydrogenases/reductases family signature
220341006651	colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008
220341006652	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
220341006653	putative trimer interface [polypeptide binding]; other site
220341006654	putative active site [active]
220341006655	putative substrate binding site [chemical binding]; other site
220341006656	putative CoA binding site [chemical binding]; other site
220341006657	PS00101 Hexapeptide-repeat containing-transferases signature
220341006658	colanic acid biosynthesis glycosyl transferase WcaE; Region: wcaE; TIGR04009
220341006659	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
220341006660	metal-binding site
220341006661	colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015
220341006662	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
220341006663	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
220341006664	putative acyl transferase; Provisional; Region: PRK10191
220341006665	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
220341006666	trimer interface [polypeptide binding]; other site
220341006667	active site
220341006668	substrate binding site [chemical binding]; other site
220341006669	CoA binding site [chemical binding]; other site
220341006670	PS00101 Hexapeptide-repeat containing-transferases signature
220341006672	tyrosine kinase; Provisional; Region: PRK11519
220341006673	Chain length determinant protein; Region: Wzz; pfam02706
220341006674	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
220341006675	AAA domain; Region: AAA_31; pfam13614
220341006676	Low molecular weight phosphatase family; Region: LMWPc; cd00115
220341006677	active site
220341006678	polysaccharide export protein Wza; Provisional; Region: PRK15078
220341006679	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
220341006680	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341006681	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
220341006682	FOG: CBS domain [General function prediction only]; Region: COG0517
220341006683	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
220341006684	Transporter associated domain; Region: CorC_HlyC; smart01091
220341006685	putative assembly protein; Provisional; Region: PRK10833
220341006686	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
220341006687	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
220341006688	trimer interface [polypeptide binding]; other site
220341006689	active site
220341006690	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
220341006691	ATP-binding site [chemical binding]; other site
220341006692	Sugar specificity; other site
220341006693	Pyrimidine base specificity; other site
220341006694	PS00017 ATP/GTP-binding site motif A (P-loop)
220341006695	Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447
220341006696	putative diguanylate cyclase; Provisional; Region: PRK09776
220341006697	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
220341006698	putative active site [active]
220341006699	heme pocket [chemical binding]; other site
220341006700	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
220341006701	putative active site [active]
220341006702	heme pocket [chemical binding]; other site
220341006703	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
220341006704	metal binding site [ion binding]; metal-binding site
220341006705	active site
220341006706	I-site; other site
220341006707	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
220341006708	3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308
220341006709	AlkA N-terminal domain; Region: AlkA_N; pfam06029
220341006710	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
220341006711	minor groove reading motif; other site
220341006712	helix-hairpin-helix signature motif; other site
220341006713	substrate binding pocket [chemical binding]; other site
220341006714	active site
220341006715	putative chaperone; Provisional; Region: PRK11678
220341006716	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
220341006717	nucleotide binding site [chemical binding]; other site
220341006718	putative NEF/HSP70 interaction site [polypeptide binding]; other site
220341006719	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
220341006720	SBD interface [polypeptide binding]; other site
220341006721	PS00329 Heat shock hsp70 proteins family signature 2
220341006722	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
220341006723	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
220341006724	HlyD family secretion protein; Region: HlyD_3; pfam13437
220341006725	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
220341006726	MMPL family; Region: MMPL; cl14618
220341006727	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
220341006728	MMPL family; Region: MMPL; cl14618
220341006729	putative transporter; Provisional; Region: PRK10504
220341006730	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341006731	putative substrate translocation pore; other site
220341006732	signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549
220341006733	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
220341006734	dimerization interface [polypeptide binding]; other site
220341006735	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
220341006736	dimer interface [polypeptide binding]; other site
220341006737	phosphorylation site [posttranslational modification]
220341006738	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
220341006739	ATP binding site [chemical binding]; other site
220341006740	Mg2+ binding site [ion binding]; other site
220341006741	G-X-G motif; other site
220341006742	DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710
220341006743	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
220341006744	active site
220341006745	phosphorylation site [posttranslational modification]
220341006746	intermolecular recognition site; other site
220341006747	dimerization interface [polypeptide binding]; other site
220341006748	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
220341006749	DNA binding site [nucleotide binding]
220341006750	PcfJ-like protein; Region: PcfJ; pfam14284
220341006751	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
220341006752	Domain of unknown function (DUF4034); Region: DUF4034; pfam13226
220341006753	Tetratricopeptide repeat; Region: TPR_12; pfam13424
220341006754	Base composition: 37.8 % G+C
220341006755	Inhibitor of the contact-dependent growth inhibition (CDI) system of Escherichia coli EC869, and related proteins; Region: CDI_inhibitor_EC869_like; cd13445
220341006756	CDI toxin binding surface [polypeptide binding]; other site
220341006758	putative protease; Provisional; Region: PRK15452
220341006759	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
220341006760	PS01276 Peptidase family U32 signature
220341006761	Tir chaperone protein (CesT) family; Region: CesT; pfam05932
220341006762	lipid kinase; Reviewed; Region: PRK13054
220341006763	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
220341006764	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
220341006765	putative active site; other site
220341006766	catalytic residue [active]
220341006767	Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825
220341006768	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341006769	putative substrate translocation pore; other site
220341006770	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341006771	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
220341006772	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
220341006773	substrate binding site [chemical binding]; other site
220341006774	ATP binding site [chemical binding]; other site
220341006775	PS00583 pfkB family of carbohydrate kinases signature 1
220341006776	PS00584 pfkB family of carbohydrate kinases signature 2
220341006777	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
220341006778	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
220341006779	DNA-binding site [nucleotide binding]; DNA binding site
220341006780	UTRA domain; Region: UTRA; pfam07702
220341006781	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
220341006782	dimer interface [polypeptide binding]; other site
220341006783	substrate binding site [chemical binding]; other site
220341006784	ATP binding site [chemical binding]; other site
220341006785	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
220341006786	substrate binding site [chemical binding]; other site
220341006787	multimerization interface [polypeptide binding]; other site
220341006788	ATP binding site [chemical binding]; other site
220341006789	Predicted integral membrane protein [Function unknown]; Region: COG5455
220341006790	putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252
220341006791	fimbrial outer membrane usher protein; Provisional; Region: PRK15217
220341006792	PapC N-terminal domain; Region: PapC_N; pfam13954
220341006793	Outer membrane usher protein; Region: Usher; pfam00577
220341006794	PapC C-terminal domain; Region: PapC_C; pfam13953
220341006795	PS01151 Fimbrial biogenesis outer membrane usher protein signature
220341006796	putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253
220341006797	Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345
220341006798	Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753
220341006799	PS00635 Gram-negative pili assembly chaperone signature
220341006800	fimbrial chaperone protein; Provisional; Region: PRK15220
220341006801	Protein of unknown function (DUF2574); Region: DUF2574; pfam10836
220341006802	antiporter inner membrane protein; Provisional; Region: PRK11670
220341006803	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
220341006804	Walker A motif; other site
220341006805	PS01215 Mrp family signature
220341006806	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
220341006807	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
220341006808	active site
220341006809	HIGH motif; other site
220341006810	KMSKS motif; other site
220341006811	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
220341006812	tRNA binding surface [nucleotide binding]; other site
220341006813	anticodon binding site; other site
220341006814	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
220341006815	dimer interface [polypeptide binding]; other site
220341006816	putative tRNA-binding site [nucleotide binding]; other site
220341006817	PS00178 Aminoacyl-transfer RNA synthetases class-I signature
220341006818	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
220341006819	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341006820	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
220341006821	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341006822	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
220341006823	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
220341006824	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
220341006825	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
220341006826	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
220341006827	active site
220341006828	phosphorylation site [posttranslational modification]
220341006829	intermolecular recognition site; other site
220341006830	dimerization interface [polypeptide binding]; other site
220341006831	LytTr DNA-binding domain; Region: LytTR; pfam04397
220341006832	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
220341006833	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
220341006834	GAF domain; Region: GAF; pfam01590
220341006835	Histidine kinase; Region: His_kinase; pfam06580
220341006836	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
220341006837	ATP binding site [chemical binding]; other site
220341006838	Mg2+ binding site [ion binding]; other site
220341006839	G-X-G motif; other site
220341006840	transcriptional regulator MirA; Provisional; Region: PRK15043
220341006841	Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763
220341006842	DNA binding residues [nucleotide binding]
220341006843	PS00552 Bacterial regulatory proteins, merR family signature
220341006844	hypothetical protein; Provisional; Region: PRK13681
220341006845	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341006846	dimer interface [polypeptide binding]; other site
220341006847	conserved gate region; other site
220341006848	putative PBP binding loops; other site
220341006849	ABC-ATPase subunit interface; other site
220341006850	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
220341006851	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
220341006852	Walker A/P-loop; other site
220341006853	ATP binding site [chemical binding]; other site
220341006854	Q-loop/lid; other site
220341006855	ABC transporter signature motif; other site
220341006856	Walker B; other site
220341006857	D-loop; other site
220341006858	H-loop/switch region; other site
220341006859	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
220341006860	PS00211 ABC transporters family signature
220341006861	PS00017 ATP/GTP-binding site motif A (P-loop)
220341006862	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341006863	dimer interface [polypeptide binding]; other site
220341006864	conserved gate region; other site
220341006865	putative PBP binding loops; other site
220341006866	ABC-ATPase subunit interface; other site
220341006867	PS00402 Binding-protein-dependent transport systems inner membrane comp sign.
220341006868	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
220341006869	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
220341006870	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
220341006871	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
220341006872	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
220341006873	PS00775 Glycosyl hydrolases family 3 active site
220341006874	D-lactate dehydrogenase; Provisional; Region: PRK11183
220341006875	FAD binding domain; Region: FAD_binding_4; cl19922
220341006876	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
220341006877	' Fasta hit to PBP7_ECOLI (313 aa), 93% identity in 302 aa overlap. Appears to have lost its start codon (with respect to E. coli pbpG) and contains a UGA stop codon. However there is an alternative start codon (used here) and possible translational read-through at codon 5 (UGA, followed 3 by G). This would result in a non-conservative substitution of W (compared to R in E. coli), but would retain a good predicted N-terminal signal sequence. The sequence has been checked and is believed to be correct'
220341006878	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
220341006879	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
220341006880	oxidoreductase; Provisional; Region: PRK12743
220341006881	classical (c) SDRs; Region: SDR_c; cd05233
220341006882	NAD(P) binding site [chemical binding]; other site
220341006883	active site
220341006884	PS00061 Short-chain dehydrogenases/reductases family signature
220341006885	multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459
220341006886	Outer membrane efflux protein; Region: OEP; pfam02321
220341006887	Outer membrane efflux protein; Region: OEP; pfam02321
220341006888	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341006889	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
220341006890	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
220341006891	FMN binding site [chemical binding]; other site
220341006892	active site
220341006893	catalytic residues [active]
220341006894	substrate binding site [chemical binding]; other site
220341006895	PS01136 Uncharacterized protein family UPF0034 signature
220341006896	salicylate hydroxylase; Provisional; Region: PRK08163
220341006897	Squalene epoxidase; Region: SE; cl17314
220341006898	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
220341006899	maleylacetoacetate isomerase; Region: maiA; TIGR01262
220341006900	C-terminal domain interface [polypeptide binding]; other site
220341006901	GSH binding site (G-site) [chemical binding]; other site
220341006902	putative dimer interface [polypeptide binding]; other site
220341006903	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
220341006904	dimer interface [polypeptide binding]; other site
220341006905	N-terminal domain interface [polypeptide binding]; other site
220341006906	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
220341006907	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
220341006908	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
220341006909	gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272
220341006910	Cupin domain; Region: Cupin_2; pfam07883
220341006911	Cupin domain; Region: Cupin_2; cl17218
220341006912	benzoate transport; Region: 2A0115; TIGR00895
220341006913	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341006914	putative substrate translocation pore; other site
220341006915	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
220341006916	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341006917	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
220341006918	dimerization interface [polypeptide binding]; other site
220341006919	PS00044 Bacterial regulatory proteins, lysR family signature
220341006920	hypothetical protein; Provisional; Region: PRK01821
220341006921	hypothetical protein; Provisional; Region: PRK10711
220341006922	cytidine deaminase; Provisional; Region: PRK09027
220341006923	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
220341006924	active site
220341006925	catalytic motif [active]
220341006926	Zn binding site [ion binding]; other site
220341006927	Cytidine and deoxycytidylate deaminase zinc-binding region; Region: dCMP_cyt_deam_2; pfam08211
220341006928	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
220341006929	active site
220341006930	catalytic motif [active]
220341006931	Zn binding site [ion binding]; other site
220341006932	PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature
220341006933	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
220341006934	putative active site [active]
220341006935	Protein of unknown function (DUF2542); Region: DUF2542; pfam10808
220341006936	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
220341006937	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691
220341006938	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
220341006939	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
220341006940	PS00190 Cytochrome c family heme-binding site signature
220341006941	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341006942	IS1 transposase; Region: DDE_Tnp_IS1; pfam03400
220341006943	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
220341006944	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
220341006945	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
220341006946	PS00017 ATP/GTP-binding site motif A (P-loop)
220341006947	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
220341006948	TM-ABC transporter signature motif; other site
220341006949	PS00211 ABC transporters family signature
220341006950	PS00017 ATP/GTP-binding site motif A (P-loop)
220341006951	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
220341006952	Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539
220341006953	ligand binding site [chemical binding]; other site
220341006954	calcium binding site [ion binding]; other site
220341006955	DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401
220341006956	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
220341006957	DNA binding site [nucleotide binding]
220341006958	domain linker motif; other site
220341006959	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
220341006960	dimerization interface (closed form) [polypeptide binding]; other site
220341006961	ligand binding site [chemical binding]; other site
220341006962	PS00356 Bacterial regulatory proteins, lacI family signature
220341006963	Predicted membrane protein [Function unknown]; Region: COG2311
220341006964	hypothetical protein; Provisional; Region: PRK10835
220341006965	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
220341006966	homodecamer interface [polypeptide binding]; other site
220341006967	active site
220341006968	putative catalytic site residues [active]
220341006969	zinc binding site [ion binding]; other site
220341006970	GTP-CH-I/GFRP interaction surface; other site
220341006971	PS00860 GTP cyclohydrolase I signature 2
220341006972	PS00859 GTP cyclohydrolase I signature 1
220341006973	Predicted esterase [General function prediction only]; Region: COG0627
220341006974	S-formylglutathione hydrolase; Region: PLN02442
220341006975	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
220341006976	non-specific DNA binding site [nucleotide binding]; other site
220341006977	salt bridge; other site
220341006978	sequence-specific DNA binding site [nucleotide binding]; other site
220341006979	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
220341006980	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
220341006981	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
220341006982	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
220341006983	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
220341006984	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
220341006985	motif II; other site
220341006986	catecholate siderophore receptor CirA; Provisional; Region: PRK10064
220341006987	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
220341006988	N-terminal plug; other site
220341006989	ligand-binding site [chemical binding]; other site
220341006990	PS01156 TonB-dependent receptor proteins signature 2
220341006991	lysine transporter; Provisional; Region: PRK10836
220341006992	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
220341006993	PS00218 Amino acid permeases signature
220341006994	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
220341006995	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341006996	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
220341006997	putative dimerization interface [polypeptide binding]; other site
220341006998	PS00044 Bacterial regulatory proteins, lysR family signature
220341006999	conserved hypothetical integral membrane protein; Region: TIGR00698
220341007000	Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648
220341007001	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
220341007002	AP (apurinic/apyrimidinic) site pocket; other site
220341007003	DNA interaction; other site
220341007004	Metal-binding active site; metal-binding site
220341007005	PS00729 AP endonucleases family 2 signature 1
220341007006	PS00730 AP endonucleases family 2 signature 2
220341007007	PS00731 AP endonucleases family 2 signature 3
220341007008	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
220341007009	N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925
220341007010	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
220341007011	active site
220341007012	P-loop; other site
220341007013	phosphorylation site [posttranslational modification]
220341007014	PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427
220341007015	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
220341007016	putative substrate binding site [chemical binding]; other site
220341007017	putative ATP binding site [chemical binding]; other site
220341007018	PS00584 pfkB family of carbohydrate kinases signature 2
220341007019	PS00583 pfkB family of carbohydrate kinases signature 1
220341007020	PS00464 Ribosomal protein L22 signature
220341007021	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109
220341007022	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
220341007023	active site
220341007024	phosphorylation site [posttranslational modification]
220341007025	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
220341007026	dimerization domain swap beta strand [polypeptide binding]; other site
220341007027	regulatory protein interface [polypeptide binding]; other site
220341007028	active site
220341007029	regulatory phosphorylation site [posttranslational modification]; other site
220341007030	PS00589 PTS HPR component serine phosphorylation site signature
220341007031	PS00369 PTS HPR component histidine phosphorylation site signature
220341007032	PS00372 PTS EIIA domains phosphorylation site signature 2
220341007033	sugar efflux transporter B; Provisional; Region: PRK15011
220341007034	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341007035	putative substrate translocation pore; other site
220341007036	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
220341007038	PS01275 Elongation factor P signature
220341007039	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
220341007040	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
220341007041	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
220341007042	PS00017 ATP/GTP-binding site motif A (P-loop)
220341007043	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
220341007044	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
220341007045	active site
220341007046	outer membrane lipoprotein; Provisional; Region: spr; PRK10838
220341007047	NlpC/P60 family; Region: NLPC_P60; pfam00877
220341007048	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341007049	phage resistance protein; Provisional; Region: PRK10551
220341007050	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
220341007051	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
220341007052	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
220341007053	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
220341007054	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
220341007055	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341007056	dimer interface [polypeptide binding]; other site
220341007057	conserved gate region; other site
220341007058	putative PBP binding loops; other site
220341007059	ABC-ATPase subunit interface; other site
220341007060	microcin C ABC transporter permease; Provisional; Region: PRK15021
220341007061	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341007062	dimer interface [polypeptide binding]; other site
220341007063	conserved gate region; other site
220341007064	putative PBP binding loops; other site
220341007065	ABC-ATPase subunit interface; other site
220341007066	PS00402 Binding-protein-dependent transport systems inner membrane comp sign.
220341007067	microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134
220341007068	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
220341007069	Walker A/P-loop; other site
220341007070	ATP binding site [chemical binding]; other site
220341007071	Q-loop/lid; other site
220341007072	ABC transporter signature motif; other site
220341007073	Walker B; other site
220341007074	D-loop; other site
220341007075	H-loop/switch region; other site
220341007076	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
220341007077	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
220341007078	Walker A/P-loop; other site
220341007079	ATP binding site [chemical binding]; other site
220341007080	Q-loop/lid; other site
220341007081	ABC transporter signature motif; other site
220341007082	Walker B; other site
220341007083	D-loop; other site
220341007084	H-loop/switch region; other site
220341007085	PS00017 ATP/GTP-binding site motif A (P-loop)
220341007086	PS00211 ABC transporters family signature
220341007087	PS00017 ATP/GTP-binding site motif A (P-loop)
220341007088	PS00211 ABC transporters family signature
220341007089	hypothetical protein; Provisional; Region: PRK11835
220341007090	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341007091	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
220341007092	putative substrate translocation pore; other site
220341007093	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
220341007094	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
220341007095	RNA binding surface [nucleotide binding]; other site
220341007096	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
220341007097	active site
220341007098	uracil binding [chemical binding]; other site
220341007099	PS01149 Rsu family of pseudouridine synthase signature
220341007100	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
220341007101	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
220341007102	ATP binding site [chemical binding]; other site
220341007103	putative Mg++ binding site [ion binding]; other site
220341007104	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
220341007105	nucleotide binding region [chemical binding]; other site
220341007106	ATP-binding site [chemical binding]; other site
220341007107	Ribosomal L40e family; Region: Ribosomal_L40e; cl00671
220341007108	PS00017 ATP/GTP-binding site motif A (P-loop)
220341007109	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
220341007110	5S rRNA interface [nucleotide binding]; other site
220341007111	CTC domain interface [polypeptide binding]; other site
220341007112	L16 interface [polypeptide binding]; other site
220341007113	nucleoid-associated protein NdpA; Validated; Region: PRK00378
220341007114	hypothetical protein; Provisional; Region: PRK13689
220341007115	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
220341007116	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
220341007117	Sulfatase; Region: Sulfatase; cl19157
220341007118	E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387
220341007119	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
220341007120	Type III secretion system leucine rich repeat protein; Region: TTSSLRR; pfam12468
220341007121	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
220341007122	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
220341007123	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116
220341007124	Leucine-rich repeats; other site
220341007125	C-terminal novel E3 ligase, LRR-interacting; Region: NEL; pfam14496
220341007126	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
220341007127	DinI-like family; Region: DinI; cl11630
220341007128	transcriptional regulator NarP; Provisional; Region: PRK10403
220341007129	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
220341007130	active site
220341007131	phosphorylation site [posttranslational modification]
220341007132	intermolecular recognition site; other site
220341007133	dimerization interface [polypeptide binding]; other site
220341007134	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
220341007135	DNA binding residues [nucleotide binding]
220341007136	dimerization interface [polypeptide binding]; other site
220341007137	PS00622 Bacterial regulatory proteins, luxR family signature
220341007138	Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088
220341007139	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
220341007140	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
220341007141	binding surface
220341007142	TPR motif; other site
220341007143	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
220341007144	catalytic residues [active]
220341007145	central insert; other site
220341007146	PS00194 Thioredoxin family active site
220341007147	c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353
220341007148	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150
220341007149	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
220341007150	heme exporter protein CcmC; Region: ccmC; TIGR01191
220341007151	heme exporter protein CcmB; Region: ccmB; TIGR01190
220341007152	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
220341007153	Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231
220341007154	Walker A/P-loop; other site
220341007155	ATP binding site [chemical binding]; other site
220341007156	Q-loop/lid; other site
220341007157	ABC transporter signature motif; other site
220341007158	Walker B; other site
220341007159	D-loop; other site
220341007160	H-loop/switch region; other site
220341007161	PS00211 ABC transporters family signature
220341007162	PS00017 ATP/GTP-binding site motif A (P-loop)
220341007163	cytochrome c-type protein NapC; Provisional; Region: PRK10617
220341007164	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
220341007165	PS00190 Cytochrome c family heme-binding site signature
220341007166	PS00190 Cytochrome c family heme-binding site signature
220341007167	PS00190 Cytochrome c family heme-binding site signature
220341007168	nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586
220341007169	PS00190 Cytochrome c family heme-binding site signature
220341007170	PS00190 Cytochrome c family heme-binding site signature
220341007171	UbiA family of prenyltransferases (PTases); Region: PT_UbiA; cl00337
220341007172	quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477
220341007173	4Fe-4S binding domain; Region: Fer4_5; pfam12801
220341007174	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
220341007175	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341007176	quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476
220341007177	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
220341007178	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
220341007179	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
220341007180	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341007181	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
220341007182	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
220341007183	[4Fe-4S] binding site [ion binding]; other site
220341007184	molybdopterin cofactor binding site; other site
220341007185	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
220341007186	molybdopterin cofactor binding site; other site
220341007187	PS00551 Prokaryotic molybdopterin oxidoreductases signature 1
220341007188	assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553
220341007189	ferredoxin-type protein; Provisional; Region: PRK10194
220341007190	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
220341007191	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341007192	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341007193	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341007194	Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242
220341007195	secondary substrate binding site; other site
220341007196	primary substrate binding site; other site
220341007197	inhibition loop; other site
220341007198	dimerization interface [polypeptide binding]; other site
220341007199	multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522
220341007200	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
220341007201	Walker A/P-loop; other site
220341007202	ATP binding site [chemical binding]; other site
220341007203	Q-loop/lid; other site
220341007204	ABC transporter signature motif; other site
220341007205	Walker B; other site
220341007206	D-loop; other site
220341007207	H-loop/switch region; other site
220341007208	PS00211 ABC transporters family signature
220341007209	PS00017 ATP/GTP-binding site motif A (P-loop)
220341007210	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
220341007211	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
220341007212	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
220341007213	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341007214	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
220341007215	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
220341007216	DNA binding site [nucleotide binding]
220341007217	active site
220341007218	PS00374 Methylated-DNA--protein-cysteine methyltransferase active site
220341007219	PS00041 Bacterial regulatory proteins, araC family signature
220341007220	PS00041 Bacterial regulatory proteins, araC family signature
220341007221	thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461
220341007222	PS00017 ATP/GTP-binding site motif A (P-loop)
220341007223	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341007224	outer membrane porin protein C; Provisional; Region: PRK10554
220341007225	PS00576 General diffusion Gram-negative porins signature
220341007226	phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618
220341007227	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
220341007228	ATP binding site [chemical binding]; other site
220341007229	G-X-G motif; other site
220341007230	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
220341007231	putative binding surface; other site
220341007232	active site
220341007233	transcriptional regulator RcsB; Provisional; Region: PRK10840
220341007234	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
220341007235	active site
220341007236	phosphorylation site [posttranslational modification]
220341007237	intermolecular recognition site; other site
220341007238	dimerization interface [polypeptide binding]; other site
220341007239	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
220341007240	DNA binding residues [nucleotide binding]
220341007241	dimerization interface [polypeptide binding]; other site
220341007242	PS00622 Bacterial regulatory proteins, luxR family signature
220341007243	hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841
220341007244	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
220341007245	dimer interface [polypeptide binding]; other site
220341007246	phosphorylation site [posttranslational modification]
220341007247	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
220341007248	ATP binding site [chemical binding]; other site
220341007249	Mg2+ binding site [ion binding]; other site
220341007250	G-X-G motif; other site
220341007251	RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456
220341007252	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
220341007253	active site
220341007254	phosphorylation site [posttranslational modification]
220341007255	intermolecular recognition site; other site
220341007256	dimerization interface [polypeptide binding]; other site
220341007257	Transposase IS200 like; Region: Y1_Tnp; pfam01797
220341007258	DNA gyrase subunit A; Validated; Region: PRK05560
220341007259	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
220341007260	CAP-like domain; other site
220341007261	active site
220341007262	primary dimer interface [polypeptide binding]; other site
220341007263	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
220341007264	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
220341007265	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
220341007266	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
220341007267	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
220341007268	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
220341007269	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
220341007270	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
220341007271	active site pocket [active]
220341007272	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
220341007273	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
220341007274	S-adenosylmethionine binding site [chemical binding]; other site
220341007275	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103
220341007276	ATP cone domain; Region: ATP-cone; pfam03477
220341007277	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
220341007278	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341007279	PS00089 Ribonucleotide reductase large subunit signature
220341007280	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
220341007281	dimer interface [polypeptide binding]; other site
220341007282	putative radical transfer pathway; other site
220341007283	diiron center [ion binding]; other site
220341007284	tyrosyl radical; other site
220341007285	PS00368 Ribonucleotide reductase small subunit signature
220341007286	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
220341007287	catalytic loop [active]
220341007288	iron binding site [ion binding]; other site
220341007289	PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature
220341007290	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
220341007291	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341007292	putative substrate translocation pore; other site
220341007293	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
220341007294	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341007295	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
220341007296	dimerization interface [polypeptide binding]; other site
220341007297	PS00044 Bacterial regulatory proteins, lysR family signature
220341007298	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
220341007299	Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600
220341007300	active site
220341007301	catalytic site [active]
220341007302	metal binding site [ion binding]; metal-binding site
220341007303	PS00017 ATP/GTP-binding site motif A (P-loop)
220341007304	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
220341007305	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341007306	putative substrate translocation pore; other site
220341007307	PS00942 glpT family of transporters signature
220341007308	sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101
220341007309	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
220341007310	PS00977 FAD-dependent glycerol-3-phosphate dehydrogenase signature 1
220341007311	PS00978 FAD-dependent glycerol-3-phosphate dehydrogenase signature 2
220341007312	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075
220341007313	FAD binding domain; Region: FAD_binding_2; pfam00890
220341007314	glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379
220341007315	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
220341007316	Cysteine-rich domain; Region: CCG; pfam02754
220341007317	Cysteine-rich domain; Region: CCG; pfam02754
220341007318	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341007319	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341007320	deubiquitinase SseL; Provisional; Region: PRK14848
220341007321	2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128
220341007322	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
220341007323	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341007324	putative substrate translocation pore; other site
220341007325	L-rhamnonate dehydratase; Provisional; Region: PRK15440
220341007326	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327
220341007327	putative active site pocket [active]
220341007328	putative metal binding site [ion binding]; other site
220341007329	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
220341007330	Transcriptional regulator [Transcription]; Region: IclR; COG1414
220341007331	Bacterial transcriptional regulator; Region: IclR; pfam01614
220341007332	PS01051 Bacterial regulatory proteins, iclR family signature
220341007333	hypothetical protein; Provisional; Region: PRK03673
220341007334	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
220341007335	putative MPT binding site; other site
220341007336	Competence-damaged protein; Region: CinA; cl00666
220341007337	YfaZ precursor; Region: YfaZ; pfam07437
220341007338	nucleoside triphosphatase NudI; Provisional; Region: PRK15472
220341007339	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
220341007340	catalytic core [active]
220341007341	lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407
220341007342	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
220341007343	inhibitor-cofactor binding pocket; inhibition site
220341007344	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341007345	catalytic residue [active]
220341007346	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
220341007347	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
220341007348	Ligand binding site; other site
220341007349	Putative Catalytic site; other site
220341007350	DXD motif; other site
220341007351	bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125
220341007352	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
220341007353	active site
220341007354	substrate binding site [chemical binding]; other site
220341007355	cosubstrate binding site; other site
220341007356	catalytic site [active]
220341007357	C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702
220341007358	active site
220341007359	hexamer interface [polypeptide binding]; other site
220341007360	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
220341007361	NAD binding site [chemical binding]; other site
220341007362	substrate binding site [chemical binding]; other site
220341007363	active site
220341007364	4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394
220341007365	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
220341007366	4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279
220341007367	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
220341007368	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051
220341007369	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
220341007370	Polymyxin resistance protein PmrD; Region: PmrD; pfam11183
220341007371	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029
220341007372	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
220341007373	acyl-activating enzyme (AAE) consensus motif; other site
220341007374	putative AMP binding site [chemical binding]; other site
220341007375	putative active site [active]
220341007376	putative CoA binding site [chemical binding]; other site
220341007377	PS00455 Putative AMP-binding domain signature
220341007378	O-succinylbenzoate synthase [Coenzyme metabolism]; Region: MenC; COG1441
220341007379	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
220341007380	active site
220341007381	dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396
220341007382	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
220341007383	substrate binding site [chemical binding]; other site
220341007384	oxyanion hole (OAH) forming residues; other site
220341007385	trimer interface [polypeptide binding]; other site
220341007386	PS00166 Enoyl-CoA hydratase/isomerase signature
220341007387	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126
220341007388	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
220341007389	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
220341007390	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
220341007391	dimer interface [polypeptide binding]; other site
220341007392	tetramer interface [polypeptide binding]; other site
220341007393	PYR/PP interface [polypeptide binding]; other site
220341007394	TPP binding site [chemical binding]; other site
220341007395	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
220341007396	TPP-binding site; other site
220341007397	menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012
220341007398	isochorismate synthases; Region: isochor_syn; TIGR00543
220341007399	hypothetical protein; Provisional; Region: PRK10404
220341007400	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
220341007401	Coenzyme A binding pocket [chemical binding]; other site
220341007402	ribonuclease BN; Region: true_RNase_BN; TIGR02649
220341007403	PS00017 ATP/GTP-binding site motif A (P-loop)
220341007404	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
220341007405	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
220341007406	active site
220341007407	phosphorylation site [posttranslational modification]
220341007408	intermolecular recognition site; other site
220341007409	dimerization interface [polypeptide binding]; other site
220341007410	NADH dehydrogenase subunit 2; Provisional; Region: ND2; MTH00200
220341007411	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
220341007412	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
220341007413	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
220341007414	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
220341007415	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
220341007416	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
220341007417	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
220341007418	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
220341007419	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
220341007420	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
220341007421	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
220341007422	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
220341007423	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341007424	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341007425	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
220341007426	PS00668 Respiratory-chain NADH dehydrogenase subunit 1 signature 2
220341007427	PS00667 Respiratory-chain NADH dehydrogenase subunit 1 signature 1
220341007428	NADH dehydrogenase subunit G; Validated; Region: PRK08166
220341007429	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
220341007430	catalytic loop [active]
220341007431	iron binding site [ion binding]; other site
220341007432	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
220341007433	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
220341007434	[4Fe-4S] binding site [ion binding]; other site
220341007435	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
220341007436	PS00643 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3
220341007437	PS00642 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2
220341007438	PS00641 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1
220341007439	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341007440	NADH dehydrogenase I subunit F; Provisional; Region: PRK11278
220341007441	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
220341007442	SLBB domain; Region: SLBB; pfam10531
220341007443	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
220341007444	PS00645 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2
220341007445	PS00644 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1
220341007446	NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905
220341007447	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
220341007448	putative dimer interface [polypeptide binding]; other site
220341007449	[2Fe-2S] cluster binding site [ion binding]; other site
220341007450	PS01099 Respiratory-chain NADH dehydrogenase 24 Kd subunit signature
220341007451	NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852
220341007452	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
220341007453	Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl19174
220341007454	PS00535 Respiratory chain NADH dehydrogenase 49 Kd subunit signature
220341007455	NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377
220341007456	PS01150 Respiratory-chain NADH dehydrogenase 20 Kd subunit signature
220341007457	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
220341007458	PS00012 Phosphopantetheine attachment site
220341007459	DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092
220341007460	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341007461	The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439
220341007462	putative dimerization interface [polypeptide binding]; other site
220341007463	PS00639 Eukaryotic thiol (cysteine) proteases histidine active site
220341007464	PS00044 Bacterial regulatory proteins, lysR family signature
220341007465	aminotransferase AlaT; Validated; Region: PRK09265
220341007466	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
220341007467	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341007468	homodimer interface [polypeptide binding]; other site
220341007469	catalytic residue [active]
220341007470	5'-nucleotidase; Provisional; Region: PRK03826
220341007471	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
220341007472	transmembrane helices; other site
220341007473	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
220341007474	TrkA-C domain; Region: TrkA_C; pfam02080
220341007475	TrkA-C domain; Region: TrkA_C; pfam02080
220341007476	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
220341007477	PS01271 Sodium:sulfate symporter family signature
220341007478	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
220341007479	putative phosphatase; Provisional; Region: PRK11587
220341007480	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
220341007481	active site
220341007482	motif I; other site
220341007483	motif II; other site
220341007484	hypothetical protein; Validated; Region: PRK05445
220341007485	hypothetical protein; Provisional; Region: PRK01816
220341007486	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
220341007487	PS01075 Acetate and butyrate kinases family signature 1
220341007488	PS01076 Acetate and butyrate kinases family signature 2
220341007489	phosphate acetyltransferase; Reviewed; Region: PRK05632
220341007490	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
220341007491	DRTGG domain; Region: DRTGG; pfam07085
220341007492	phosphate acetyltransferase; Region: pta; TIGR00651
220341007493	hypothetical protein; Provisional; Region: PRK11588
220341007494	PS00012 Phosphopantetheine attachment site
220341007495	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
220341007496	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
220341007497	PYR/PP interface [polypeptide binding]; other site
220341007498	dimer interface [polypeptide binding]; other site
220341007499	TPP binding site [chemical binding]; other site
220341007500	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
220341007501	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
220341007502	TPP-binding site [chemical binding]; other site
220341007503	dimer interface [polypeptide binding]; other site
220341007504	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK12996
220341007505	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
220341007506	active site
220341007507	P-loop; other site
220341007508	phosphorylation site [posttranslational modification]
220341007509	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
220341007510	active site
220341007511	phosphorylation site [posttranslational modification]
220341007512	Transcriptional regulators [Transcription]; Region: PurR; COG1609
220341007513	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
220341007514	DNA binding site [nucleotide binding]
220341007515	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
220341007516	putative dimerization interface [polypeptide binding]; other site
220341007517	putative ligand binding site [chemical binding]; other site
220341007518	PS00356 Bacterial regulatory proteins, lacI family signature
220341007519	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697
220341007520	nudix motif; other site
220341007521	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
220341007522	active site
220341007523	metal binding site [ion binding]; metal-binding site
220341007524	homotetramer interface [polypeptide binding]; other site
220341007525	PS01269 Uncharacterized protein family UPF0025 signature
220341007526	glutathione S-transferase; Provisional; Region: PRK15113
220341007527	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
220341007528	C-terminal domain interface [polypeptide binding]; other site
220341007529	GSH binding site (G-site) [chemical binding]; other site
220341007530	dimer interface [polypeptide binding]; other site
220341007531	C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195
220341007532	N-terminal domain interface [polypeptide binding]; other site
220341007533	putative dimer interface [polypeptide binding]; other site
220341007534	putative substrate binding pocket (H-site) [chemical binding]; other site
220341007535	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
220341007536	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
220341007537	C-terminal domain interface [polypeptide binding]; other site
220341007538	GSH binding site (G-site) [chemical binding]; other site
220341007539	dimer interface [polypeptide binding]; other site
220341007540	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
220341007541	N-terminal domain interface [polypeptide binding]; other site
220341007542	putative dimer interface [polypeptide binding]; other site
220341007543	active site
220341007544	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
220341007545	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
220341007546	putative NAD(P) binding site [chemical binding]; other site
220341007547	putative active site [active]
220341007548	histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619
220341007549	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
220341007550	Walker A/P-loop; other site
220341007551	ATP binding site [chemical binding]; other site
220341007552	Q-loop/lid; other site
220341007553	ABC transporter signature motif; other site
220341007554	Walker B; other site
220341007555	D-loop; other site
220341007556	H-loop/switch region; other site
220341007557	PS00211 ABC transporters family signature
220341007558	PS00017 ATP/GTP-binding site motif A (P-loop)
220341007559	ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism]; Region: ArtM; COG4160
220341007560	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341007561	dimer interface [polypeptide binding]; other site
220341007562	conserved gate region; other site
220341007563	putative PBP binding loops; other site
220341007564	ABC-ATPase subunit interface; other site
220341007565	PS00402 Binding-protein-dependent transport systems inner membrane comp sign.
220341007566	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
220341007567	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341007568	dimer interface [polypeptide binding]; other site
220341007569	conserved gate region; other site
220341007570	putative PBP binding loops; other site
220341007571	ABC-ATPase subunit interface; other site
220341007572	PS00017 ATP/GTP-binding site motif A (P-loop)
220341007573	PS00402 Binding-protein-dependent transport systems inner membrane comp sign.
220341007574	histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437
220341007575	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
220341007576	substrate binding pocket [chemical binding]; other site
220341007577	membrane-bound complex binding site; other site
220341007578	hinge residues; other site
220341007579	PS01039 Bacterial extracellular solute-binding proteins, family 3 signature
220341007580	ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010
220341007581	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
220341007582	substrate binding pocket [chemical binding]; other site
220341007583	membrane-bound complex binding site; other site
220341007584	hinge residues; other site
220341007585	PS01039 Bacterial extracellular solute-binding proteins, family 3 signature
220341007586	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
220341007587	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
220341007588	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
220341007589	PS00017 ATP/GTP-binding site motif A (P-loop)
220341007590	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
220341007591	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815
220341007592	dimer interface [polypeptide binding]; other site
220341007593	active site
220341007594	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
220341007595	substrate binding site [chemical binding]; other site
220341007596	catalytic residue [active]
220341007597	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
220341007598	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
220341007599	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341007600	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
220341007601	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
220341007602	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
220341007603	catalytic residue [active]
220341007604	PAS fold; Region: PAS_4; pfam08448
220341007605	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
220341007606	putative active site [active]
220341007607	heme pocket [chemical binding]; other site
220341007608	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
220341007609	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
220341007610	Walker A motif; other site
220341007611	ATP binding site [chemical binding]; other site
220341007612	Walker B motif; other site
220341007613	arginine finger; other site
220341007614	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
220341007615	PS00676 Sigma-54 interaction domain ATP-binding region B signature
220341007616	amidophosphoribosyltransferase; Provisional; Region: PRK09246
220341007617	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
220341007618	active site
220341007619	tetramer interface [polypeptide binding]; other site
220341007620	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
220341007621	active site
220341007622	PS00103 Purine/pyrimidine phosphoribosyl transferases signature
220341007623	colicin V production protein; Provisional; Region: PRK10845
220341007624	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341007625	cell division protein DedD; Provisional; Region: PRK11633
220341007626	Modulator of retrovirus infection; Region: MRI; pfam15325
220341007627	Sporulation related domain; Region: SPOR; pfam05036
220341007628	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
220341007629	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
220341007630	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
220341007631	PS01012 Folylpolyglutamate synthase signature 2
220341007632	PS01011 Folylpolyglutamate synthase signature 1
220341007633	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
220341007634	hypothetical protein; Provisional; Region: PRK10847
220341007635	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
220341007636	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
220341007637	dimerization interface 3.5A [polypeptide binding]; other site
220341007638	active site
220341007639	putative semialdehyde dehydrogenase; Provisional; Region: PRK08040
220341007640	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118
220341007641	Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774
220341007642	erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438
220341007643	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
220341007644	ligand binding site [chemical binding]; other site
220341007645	NAD binding site [chemical binding]; other site
220341007646	catalytic site [active]
220341007647	homodimer interface [polypeptide binding]; other site
220341007648	PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3
220341007649	PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature
220341007650	flagella biosynthesis regulator; Provisional; Region: flk; PRK10715
220341007651	putative transporter; Provisional; Region: PRK12382
220341007652	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341007653	putative substrate translocation pore; other site
220341007654	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
220341007655	non-specific DNA binding site [nucleotide binding]; other site
220341007656	salt bridge; other site
220341007657	sequence-specific DNA binding site [nucleotide binding]; other site
220341007658	Protein of unknown function (DUF3828); Region: DUF3828; pfam12883
220341007659	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341007660	CAAX protease self-immunity; Region: Abi; pfam02517
220341007661	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
220341007662	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
220341007663	dimer interface [polypeptide binding]; other site
220341007664	active site
220341007665	PS00606 Beta-ketoacyl synthases active site
220341007666	Uncharacterized conserved protein [Function unknown]; Region: COG4121
220341007667	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
220341007668	tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197
220341007669	PS00659 Glycosyl hydrolases family 5 signature
220341007670	YfcL protein; Region: YfcL; pfam08891
220341007671	hypothetical protein; Provisional; Region: PRK10621
220341007672	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
220341007673	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
220341007674	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
220341007675	Tetramer interface [polypeptide binding]; other site
220341007676	active site
220341007677	FMN-binding site [chemical binding]; other site
220341007678	PS00789 Chorismate synthase signature 3
220341007679	PS00788 Chorismate synthase signature 2
220341007680	PS00787 Chorismate synthase signature 1
220341007681	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK11805
220341007682	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
220341007683	S-adenosylmethionine binding site [chemical binding]; other site
220341007684	PS00092 N-6 Adenine-specific DNA methylases signature
220341007685	hypothetical protein; Provisional; Region: PRK04946
220341007686	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
220341007687	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
220341007688	catalytic core [active]
220341007689	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
220341007690	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
220341007691	substrate binding site [chemical binding]; other site
220341007692	oxyanion hole (OAH) forming residues; other site
220341007693	trimer interface [polypeptide binding]; other site
220341007694	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
220341007695	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
220341007696	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
220341007697	PS00067 3-hydroxyacyl-CoA dehydrogenase signature
220341007698	3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963
220341007699	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
220341007700	dimer interface [polypeptide binding]; other site
220341007701	active site
220341007702	PS00099 Thiolases active site
220341007703	PS00737 Thiolases signature 2
220341007704	PS00098 Thiolases acyl-enzyme intermediate signature
220341007705	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691
220341007706	long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716
220341007707	ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091
220341007708	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341007709	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
220341007710	Predicted membrane protein [Function unknown]; Region: COG2246
220341007711	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
220341007712	Outer membrane protease [Cell envelope biogenesis, outer membrane]; Region: OmpT; COG4571
220341007713	PS00835 Serine proteases, omptin family signature 2
220341007714	PS00834 Serine proteases, omptin family signature 1
220341007715	PS00018 EF-hand calcium-binding domain
220341007716	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
220341007717	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
220341007718	active site
220341007719	phosphorylation site [posttranslational modification]
220341007720	intermolecular recognition site; other site
220341007721	dimerization interface [polypeptide binding]; other site
220341007722	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
220341007723	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
220341007724	PS00688 Sigma-54 interaction domain C-terminal part signature
220341007725	Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192
220341007726	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
220341007727	dimerization interface [polypeptide binding]; other site
220341007728	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
220341007729	dimer interface [polypeptide binding]; other site
220341007730	phosphorylation site [posttranslational modification]
220341007731	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
220341007732	ATP binding site [chemical binding]; other site
220341007733	Mg2+ binding site [ion binding]; other site
220341007734	G-X-G motif; other site
220341007735	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
220341007736	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
220341007737	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341007738	putative substrate translocation pore; other site
220341007739	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341007740	PS00942 glpT family of transporters signature
220341007741	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341007742	Protein of unknown function (DUF2545); Region: DUF2545; pfam10810
220341007743	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
220341007744	putative acyl-acceptor binding pocket; other site
220341007745	Transposase IS200 like; Region: Y1_Tnp; pfam01797
220341007746	aminotransferase; Validated; Region: PRK08175
220341007747	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
220341007748	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341007749	homodimer interface [polypeptide binding]; other site
220341007750	catalytic residue [active]
220341007751	glucokinase; Provisional; Region: glk; PRK00292
220341007752	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
220341007753	Cl- selectivity filter; other site
220341007754	Cl- binding residues [ion binding]; other site
220341007755	pore gating glutamate residue; other site
220341007756	dimer interface [polypeptide binding]; other site
220341007757	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
220341007758	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
220341007759	dimer interface [polypeptide binding]; other site
220341007760	PYR/PP interface [polypeptide binding]; other site
220341007761	TPP binding site [chemical binding]; other site
220341007762	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
220341007763	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
220341007764	TPP-binding site [chemical binding]; other site
220341007765	dimer interface [polypeptide binding]; other site
220341007766	PS00187 Thiamine pyrophosphate enzymes signature
220341007767	PS00626 Regulator of chromosome condensation (RCC1) signature 2
220341007768	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
220341007769	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
220341007770	active site
220341007771	catalytic tetrad [active]
220341007772	Protein of unknown function (DUF2502); Region: DUF2502; pfam10697
220341007773	manganese transport protein MntH; Reviewed; Region: PRK00701
220341007774	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
220341007775	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
220341007776	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
220341007777	Nucleoside recognition; Region: Gate; pfam07670
220341007778	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
220341007779	MASE1; Region: MASE1; pfam05231
220341007780	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
220341007781	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
220341007782	Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037
220341007783	Winged helix-turn helix; Region: HTH_29; pfam13551
220341007784	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
220341007785	salt bridge; other site
220341007786	non-specific DNA binding site [nucleotide binding]; other site
220341007787	Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037
220341007788	sequence-specific DNA binding site [nucleotide binding]; other site
220341007789	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
220341007790	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
220341007791	active site
220341007792	HIGH motif; other site
220341007793	KMSKS motif; other site
220341007794	Protein of unknown function (DUF3150); Region: DUF3150; pfam11348
220341007795	PS00178 Aminoacyl-transfer RNA synthetases class-I signature
220341007796	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
220341007797	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341007798	The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449
220341007799	putative dimerization interface [polypeptide binding]; other site
220341007800	putative substrate binding pocket [chemical binding]; other site
220341007801	PS00044 Bacterial regulatory proteins, lysR family signature
220341007802	XapX domain; Region: XapX; TIGR03510
220341007803	nucleoside transporter; Region: 2A0110; TIGR00889
220341007804	Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825
220341007805	purine nucleoside phosphorylase; Provisional; Region: PRK08202
220341007806	Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005
220341007807	hypothetical protein; Provisional; Region: PRK11528
220341007808	Transcriptional regulator [Transcription]; Region: LysR; COG0583
220341007809	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341007810	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
220341007811	putative dimerization interface [polypeptide binding]; other site
220341007812	PS00044 Bacterial regulatory proteins, lysR family signature
220341007813	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
220341007814	Protein of unknown function (DUF3820); Region: DUF3820; cl01411
220341007815	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
220341007816	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
220341007817	nucleotide binding pocket [chemical binding]; other site
220341007818	K-X-D-G motif; other site
220341007819	catalytic site [active]
220341007820	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
220341007821	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
220341007822	Helix-hairpin-helix domain; Region: HHH_5; pfam14520
220341007823	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
220341007824	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
220341007825	Dimer interface [polypeptide binding]; other site
220341007826	BRCT sequence motif; other site
220341007827	PS01056 NAD-dependent DNA ligase signature 2
220341007828	PS01055 NAD-dependent DNA ligase signature 1
220341007829	cell division protein ZipA; Provisional; Region: PRK03427
220341007830	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231
220341007831	FtsZ protein binding site [polypeptide binding]; other site
220341007832	putative sulfate transport protein CysZ; Validated; Region: PRK04949
220341007833	cysteine synthase; Region: PLN02565
220341007834	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
220341007835	dimer interface [polypeptide binding]; other site
220341007836	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341007837	catalytic residue [active]
220341007838	PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site
220341007839	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
220341007840	dimerization domain swap beta strand [polypeptide binding]; other site
220341007841	regulatory protein interface [polypeptide binding]; other site
220341007842	active site
220341007843	regulatory phosphorylation site [posttranslational modification]; other site
220341007844	PS00369 PTS HPR component histidine phosphorylation site signature
220341007845	PS00589 PTS HPR component serine phosphorylation site signature
220341007846	PS00370 PEP-utilizing enzymes phosphorylation site signature
220341007847	PS00742 PEP-utilizing enzymes signature 2
220341007848	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
220341007849	HPr interaction site; other site
220341007850	glycerol kinase (GK) interaction site [polypeptide binding]; other site
220341007851	active site
220341007852	phosphorylation site [posttranslational modification]
220341007853	PS00371 PTS EIIA domains phosphorylation site signature 1
220341007854	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341007855	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
220341007856	dimer interface [polypeptide binding]; other site
220341007857	pyridoxal binding site [chemical binding]; other site
220341007858	ATP binding site [chemical binding]; other site
220341007859	transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481
220341007860	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
220341007861	DNA-binding site [nucleotide binding]; DNA binding site
220341007862	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
220341007863	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341007864	homodimer interface [polypeptide binding]; other site
220341007865	catalytic residue [active]
220341007866	PS00043 Bacterial regulatory proteins, gntR family signature
220341007867	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
220341007868	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
220341007869	catalytic triad [active]
220341007870	hypothetical protein; Provisional; Region: PRK10318
220341007871	cysteine synthase; Region: PLN02565
220341007872	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
220341007873	dimer interface [polypeptide binding]; other site
220341007874	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341007875	catalytic residue [active]
220341007876	PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site
220341007877	sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851
220341007878	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
220341007879	Walker A/P-loop; other site
220341007880	ATP binding site [chemical binding]; other site
220341007881	Q-loop/lid; other site
220341007882	ABC transporter signature motif; other site
220341007883	Walker B; other site
220341007884	D-loop; other site
220341007885	H-loop/switch region; other site
220341007886	TOBE-like domain; Region: TOBE_3; pfam12857
220341007887	PS00211 ABC transporters family signature
220341007888	PS00017 ATP/GTP-binding site motif A (P-loop)
220341007889	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
220341007890	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341007891	dimer interface [polypeptide binding]; other site
220341007892	conserved gate region; other site
220341007893	putative PBP binding loops; other site
220341007894	ABC-ATPase subunit interface; other site
220341007895	PS00402 Binding-protein-dependent transport systems inner membrane comp sign.
220341007896	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
220341007897	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341007898	dimer interface [polypeptide binding]; other site
220341007899	conserved gate region; other site
220341007900	putative PBP binding loops; other site
220341007901	ABC-ATPase subunit interface; other site
220341007902	PS00402 Binding-protein-dependent transport systems inner membrane comp sign.
220341007903	thiosulfate transporter subunit; Provisional; Region: PRK10852
220341007904	PS00757 Prokaryotic sulfate-binding proteins signature 2
220341007905	PS00401 Prokaryotic sulfate-binding proteins signature 1
220341007906	PS00092 N-6 Adenine-specific DNA methylases signature
220341007907	short chain dehydrogenase; Provisional; Region: PRK08226
220341007908	human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368
220341007909	NAD binding site [chemical binding]; other site
220341007910	homotetramer interface [polypeptide binding]; other site
220341007911	homodimer interface [polypeptide binding]; other site
220341007912	active site
220341007913	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
220341007914	RpoE-regulated lipoprotein; Provisional; Region: PRK10718
220341007915	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341007916	Protein of unknown function (DUF2919); Region: DUF2919; pfam11143
220341007917	putative acetyltransferase; Provisional; Region: PRK03624
220341007918	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
220341007919	Coenzyme A binding pocket [chemical binding]; other site
220341007920	N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319
220341007921	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
220341007922	active site
220341007923	metal binding site [ion binding]; metal-binding site
220341007924	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
220341007925	PS01021 Coproporphyrinogen III oxidase signature
220341007926	transcriptional regulator EutR; Provisional; Region: PRK10130
220341007927	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341007928	PS00041 Bacterial regulatory proteins, araC family signature
220341007929	carboxysome structural protein EutK; Provisional; Region: PRK15466
220341007930	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
220341007931	Hexamer interface [polypeptide binding]; other site
220341007932	Hexagonal pore residue; other site
220341007933	PS01139 Bacterial microcompartiments proteins signature
220341007934	ethanolamine utilization protein EutL; Provisional; Region: PRK15405
220341007935	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
220341007936	Hexamer interface [polypeptide binding]; other site
220341007937	Hexagonal pore residue; other site
220341007938	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050
220341007939	putative hexamer interface [polypeptide binding]; other site
220341007940	putative hexagonal pore; other site
220341007941	Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302
220341007942	Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303
220341007943	Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition [Amino acid transport and metabolism]; Region: EutA; COG4819
220341007944	Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192
220341007945	iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551
220341007946	active site
220341007947	metal binding site [ion binding]; metal-binding site
220341007948	PS00060 Iron-containing alcohol dehydrogenases signature 2
220341007949	PS00017 ATP/GTP-binding site motif A (P-loop)
220341007950	PS00913 Iron-containing alcohol dehydrogenases signature 1
220341007951	Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820
220341007952	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
220341007953	nucleotide binding site [chemical binding]; other site
220341007954	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
220341007955	nucleotide binding site [chemical binding]; other site
220341007956	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
220341007957	putative catalytic cysteine [active]
220341007958	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
220341007959	Hexamer/Pentamer interface [polypeptide binding]; other site
220341007960	central pore; other site
220341007961	PS01139 Bacterial microcompartiments proteins signature
220341007962	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
220341007963	ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020
220341007964	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
220341007965	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
220341007966	G1 box; other site
220341007967	GTP/Mg2+ binding site [chemical binding]; other site
220341007968	G2 box; other site
220341007969	Switch I region; other site
220341007970	G3 box; other site
220341007971	Switch II region; other site
220341007972	G4 box; other site
220341007973	G5 box; other site
220341007974	PS00017 ATP/GTP-binding site motif A (P-loop)
220341007975	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
220341007976	putative hexamer interface [polypeptide binding]; other site
220341007977	putative hexagonal pore; other site
220341007978	Transposase IS200 like; Region: Y1_Tnp; pfam01797
220341007979	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
220341007980	Malic enzyme, N-terminal domain; Region: malic; pfam00390
220341007981	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
220341007982	putative NAD(P) binding site [chemical binding]; other site
220341007983	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
220341007984	transaldolase-like protein; Provisional; Region: PTZ00411
220341007985	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
220341007986	active site
220341007987	dimer interface [polypeptide binding]; other site
220341007988	catalytic residue [active]
220341007989	PS01054 Transaldolase signature 1
220341007990	PS00958 Transaldolase active site
220341007991	transketolase; Reviewed; Region: PRK12753
220341007992	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
220341007993	TPP-binding site [chemical binding]; other site
220341007994	dimer interface [polypeptide binding]; other site
220341007995	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
220341007996	PYR/PP interface [polypeptide binding]; other site
220341007997	dimer interface [polypeptide binding]; other site
220341007998	TPP binding site [chemical binding]; other site
220341007999	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
220341008000	PS00801 Transketolase signature 1
220341008001	PS00802 Transketolase signature 2
220341008002	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
220341008003	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
220341008004	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
220341008005	dimer interface [polypeptide binding]; other site
220341008006	ADP-ribose binding site [chemical binding]; other site
220341008007	active site
220341008008	nudix motif; other site
220341008009	metal binding site [ion binding]; metal-binding site
220341008010	putative periplasmic esterase; Provisional; Region: PRK03642
220341008011	putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769
220341008012	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
220341008013	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691
220341008014	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
220341008015	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
220341008016	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
220341008017	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341008018	PS00190 Cytochrome c family heme-binding site signature
220341008019	nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935
220341008020	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
220341008021	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
220341008022	dimerization interface [polypeptide binding]; other site
220341008023	Histidine kinase; Region: HisKA_3; pfam07730
220341008024	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
220341008025	ATP binding site [chemical binding]; other site
220341008026	Mg2+ binding site [ion binding]; other site
220341008027	G-X-G motif; other site
220341008028	aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555
220341008029	MMPL family; Region: MMPL; cl14618
220341008030	MMPL family; Region: MMPL; cl14618
220341008031	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
220341008032	putative catalytic residues [active]
220341008033	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
220341008034	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
220341008035	metal binding site [ion binding]; metal-binding site
220341008036	dimer interface [polypeptide binding]; other site
220341008037	PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1
220341008038	PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2
220341008039	hypothetical protein; Provisional; Region: PRK13664
220341008040	Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444
220341008041	Domain of unknown function (DUF1726); Region: DUF1726; pfam08351
220341008042	Helicase; Region: Helicase_RecD; pfam05127
220341008043	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
220341008044	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
220341008045	Coenzyme A binding pocket [chemical binding]; other site
220341008046	Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725
220341008047	PS00017 ATP/GTP-binding site motif A (P-loop)
220341008048	Predicted metalloprotease [General function prediction only]; Region: COG2321
220341008049	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
220341008050	ATP binding site [chemical binding]; other site
220341008051	active site
220341008052	substrate binding site [chemical binding]; other site
220341008053	PS01058 SAICAR synthetase signature 2
220341008054	PS01057 SAICAR synthetase signature 1
220341008055	lipoprotein; Provisional; Region: PRK11679
220341008056	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341008057	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
220341008058	dimer interface [polypeptide binding]; other site
220341008059	active site
220341008060	catalytic residue [active]
220341008061	PS00666 Dihydrodipicolinate synthetase signature 2
220341008062	PS00665 Dihydrodipicolinate synthetase signature 1
220341008063	glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589
220341008064	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893
220341008065	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
220341008066	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
220341008067	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
220341008068	catalytic triad [active]
220341008069	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
220341008070	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
220341008071	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
220341008072	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
220341008073	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
220341008074	Peptidase family M48; Region: Peptidase_M48; cl12018
220341008075	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
220341008076	catalytic residues [active]
220341008077	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
220341008078	DNA replication initiation factor; Provisional; Region: PRK08084
220341008079	uracil transporter; Provisional; Region: PRK10720
220341008080	uracil-xanthine permease; Region: ncs2; TIGR00801
220341008081	PS01116 Xanthine/uracil permeases family signature
220341008082	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
220341008083	active site
220341008084	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
220341008085	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
220341008086	dimerization interface [polypeptide binding]; other site
220341008087	putative ATP binding site [chemical binding]; other site
220341008088	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
220341008089	active site
220341008090	substrate binding site [chemical binding]; other site
220341008091	cosubstrate binding site; other site
220341008092	catalytic site [active]
220341008093	PS00373 Phosphoribosylglycinamide formyltransferase active site
220341008094	Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855
220341008095	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
220341008096	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
220341008097	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
220341008098	putative active site [active]
220341008099	catalytic site [active]
220341008100	Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167
220341008101	domain interface [polypeptide binding]; other site
220341008102	active site
220341008103	catalytic site [active]
220341008104	exopolyphosphatase; Provisional; Region: PRK10854
220341008105	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
220341008106	nucleotide binding site [chemical binding]; other site
220341008107	MASE1; Region: MASE1; pfam05231
220341008108	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
220341008109	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
220341008110	'P76572 (172 aa), 84% identity in 164 aa overlap. Missing start codon due frameshift after codon 4. There is an alternative TTG start codon, however using this would remove the N-terminal lysine residues and would be likely prevent correct expression of the lipoprotein. The sequence has been checked and is believed be correct'
220341008111	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341008112	GMP synthase; Reviewed; Region: guaA; PRK00074
220341008113	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
220341008114	AMP/PPi binding site [chemical binding]; other site
220341008115	candidate oxyanion hole; other site
220341008116	catalytic triad [active]
220341008117	potential glutamine specificity residues [chemical binding]; other site
220341008118	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
220341008119	ATP Binding subdomain [chemical binding]; other site
220341008120	Ligand Binding sites [chemical binding]; other site
220341008121	Dimerization subdomain; other site
220341008122	PS00442 Glutamine amidotransferases class-I active site
220341008123	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
220341008124	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
220341008125	active site
220341008126	Domain in cystathionine beta-synthase and other proteins; Region: CBS; smart00116
220341008127	PS00487 IMP dehydrogenase / GMP reductase signature
220341008128	exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237
220341008129	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
220341008130	generic binding surface II; other site
220341008131	generic binding surface I; other site
220341008132	Insertion relative to Escherichia coli
220341008133	PS00017 ATP/GTP-binding site motif A (P-loop)
220341008134	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
220341008135	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
220341008136	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
220341008137	outer membrane protein RatA; Provisional; Region: PRK15315
220341008138	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
220341008139	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
220341008140	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
220341008141	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
220341008142	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
220341008143	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
220341008144	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
220341008145	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
220341008146	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
220341008147	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
220341008148	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
220341008149	Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688
220341008150	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
220341008151	intimin-like protein SinH; Provisional; Region: PRK15318
220341008152	zinc-ribbons; Region: zinc-ribbons_6; pfam07191
220341008153	GTP-binding protein Der; Reviewed; Region: PRK00093
220341008154	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
220341008155	G1 box; other site
220341008156	GTP/Mg2+ binding site [chemical binding]; other site
220341008157	Switch I region; other site
220341008158	G2 box; other site
220341008159	Switch II region; other site
220341008160	G3 box; other site
220341008161	G4 box; other site
220341008162	G5 box; other site
220341008163	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
220341008164	G1 box; other site
220341008165	GTP/Mg2+ binding site [chemical binding]; other site
220341008166	Switch I region; other site
220341008167	G2 box; other site
220341008168	G3 box; other site
220341008169	Switch II region; other site
220341008170	G4 box; other site
220341008171	G5 box; other site
220341008172	KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714
220341008173	PS00017 ATP/GTP-binding site motif A (P-loop)
220341008174	PS00017 ATP/GTP-binding site motif A (P-loop)
220341008175	outer membrane biogenesis protein BamB; Provisional; Region: PRK11138
220341008176	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
220341008177	Trp docking motif [polypeptide binding]; other site
220341008178	active site
220341008179	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341008180	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
220341008181	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
220341008182	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
220341008183	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
220341008184	dimer interface [polypeptide binding]; other site
220341008185	motif 1; other site
220341008186	active site
220341008187	motif 2; other site
220341008188	motif 3; other site
220341008189	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
220341008190	anticodon binding site; other site
220341008191	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2
220341008192	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
220341008193	1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612
220341008194	cytoskeletal protein RodZ; Provisional; Region: PRK10856
220341008195	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
220341008196	non-specific DNA binding site [nucleotide binding]; other site
220341008197	salt bridge; other site
220341008198	sequence-specific DNA binding site [nucleotide binding]; other site
220341008199	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
220341008200	23S rRNA m2A2503 methyltransferase; Region: TIGR00048
220341008201	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
220341008202	FeS/SAM binding site; other site
220341008203	Nucleoside diphosphate kinase; Region: NDK; pfam00334
220341008204	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
220341008205	active site
220341008206	multimer interface [polypeptide binding]; other site
220341008207	PS00469 Nucleoside diphosphate kinases active site
220341008208	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
220341008209	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
220341008210	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
220341008211	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341008212	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341008213	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341008214	DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302
220341008215	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341008216	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
220341008217	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
220341008218	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341008219	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341008220	PS00490 Prokaryotic molybdopterin oxidoreductases signature 2
220341008221	penicillin-binding protein 1C; Provisional; Region: PRK11240
220341008222	Transglycosylase; Region: Transgly; pfam00912
220341008223	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
220341008224	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
220341008225	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
220341008226	MG2 domain; Region: A2M_N; pfam01835
220341008227	Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703
220341008228	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
220341008229	surface patch; other site
220341008230	thioester region; other site
220341008231	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341008232	3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493
220341008233	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
220341008234	active site residue [active]
220341008235	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
220341008236	active site residue [active]
220341008237	PS00380 Rhodanese signature 1
220341008238	PS00683 Rhodanese C-terminal signature
220341008239	SseB protein N-terminal domain; Region: SseB; pfam07179
220341008240	enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611
220341008241	SseB protein C-terminal domain; Region: SseB_C; pfam14581
220341008242	aminopeptidase B; Provisional; Region: PRK05015
220341008243	Peptidase; Region: DUF3663; pfam12404
220341008244	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
220341008245	interface (dimer of trimers) [polypeptide binding]; other site
220341008246	Substrate-binding/catalytic site; other site
220341008247	Zn-binding sites [ion binding]; other site
220341008248	PS00631 Cytosol aminopeptidase signature
220341008249	hypothetical protein; Provisional; Region: PRK10721
220341008250	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
220341008251	catalytic loop [active]
220341008252	iron binding site [ion binding]; other site
220341008253	PS00814 Adrenodoxin family, iron-sulfur binding region signature
220341008254	chaperone protein HscA; Provisional; Region: hscA; PRK05183
220341008255	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
220341008256	nucleotide binding site [chemical binding]; other site
220341008257	putative NEF/HSP70 interaction site [polypeptide binding]; other site
220341008258	SBD interface [polypeptide binding]; other site
220341008259	PS01036 Heat shock hsp70 proteins family signature 3
220341008260	PS00329 Heat shock hsp70 proteins family signature 2
220341008261	PS00297 Heat shock hsp70 proteins family signature 1
220341008262	co-chaperone HscB; Provisional; Region: hscB; PRK05014
220341008263	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
220341008264	HSP70 interaction site [polypeptide binding]; other site
220341008265	HSCB C-terminal oligomerization domain; Region: HSCB_C; pfam07743
220341008266	iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502
220341008267	PS01152 Hypothetical hesB/yadR/yfhF family signature
220341008268	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
220341008269	trimerization site [polypeptide binding]; other site
220341008270	active site
220341008271	cysteine desulfurase; Provisional; Region: PRK14012
220341008272	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
220341008273	catalytic residue [active]
220341008274	PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site
220341008275	DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857
220341008276	Rrf2 family protein; Region: rrf2_super; TIGR00738
220341008277	PS01332 Uncharacterized protein family UPF0074 signature
220341008278	tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114
220341008279	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
220341008280	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
220341008281	active site
220341008282	dimerization interface [polypeptide binding]; other site
220341008283	PS00629 Inositol monophosphatase family signature 1
220341008284	PS00630 Inositol monophosphatase family signature 2
220341008285	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
220341008286	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
220341008287	anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055
220341008288	sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910
220341008289	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341008290	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341008291	anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221
220341008292	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
220341008293	FAD binding pocket [chemical binding]; other site
220341008294	FAD binding motif [chemical binding]; other site
220341008295	phosphate binding motif [ion binding]; other site
220341008296	beta-alpha-beta structure motif; other site
220341008297	NAD binding pocket [chemical binding]; other site
220341008298	Iron coordination center [ion binding]; other site
220341008299	sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912
220341008300	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
220341008301	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
220341008302	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
220341008303	PS00365 Nitrite and sulfite reductases iron-sulfur/siroheme-binding site
220341008304	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341008305	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683
220341008306	stationary phase inducible protein CsiE; Provisional; Region: PRK11564
220341008307	PRD domain; Region: PRD; pfam00874
220341008308	PRD domain; Region: PRD; pfam00874
220341008309	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341008310	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341008311	LacY proton/sugar symporter; Region: LacY_symp; pfam01306
220341008312	putative substrate translocation pore; other site
220341008313	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
220341008314	dimer interface [polypeptide binding]; other site
220341008315	active site
220341008316	glycine-pyridoxal phosphate binding site [chemical binding]; other site
220341008317	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
220341008318	folate binding site [chemical binding]; other site
220341008319	PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site
220341008320	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
220341008321	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
220341008322	heme-binding site [chemical binding]; other site
220341008323	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
220341008324	FAD binding pocket [chemical binding]; other site
220341008325	FAD binding motif [chemical binding]; other site
220341008326	phosphate binding motif [ion binding]; other site
220341008327	beta-alpha-beta structure motif; other site
220341008328	NAD binding pocket [chemical binding]; other site
220341008329	Heme binding  pocket [chemical binding]; other site
220341008330	DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153
220341008331	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
220341008332	DNA binding site [nucleotide binding]
220341008333	lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435
220341008334	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
220341008335	lysine decarboxylase CadA; Provisional; Region: PRK15400
220341008336	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
220341008337	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
220341008338	homodimer interface [polypeptide binding]; other site
220341008339	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341008340	catalytic residue [active]
220341008341	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
220341008342	PS00703 Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
220341008343	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
220341008344	POT family; Region: PTR2; cl17359
220341008345	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341008346	putative substrate translocation pore; other site
220341008347	PS01022 PTR2 family proton/oligopeptide symporters signature 1
220341008348	PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature
220341008349	PS01023 PTR2 family proton/oligopeptide symporters signature 2
220341008350	nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858
220341008351	PS00638 P-II protein C-terminal region signature
220341008352	PS00496 P-II protein urydylation site
220341008353	response regulator GlrR; Provisional; Region: PRK15115
220341008354	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
220341008355	active site
220341008356	phosphorylation site [posttranslational modification]
220341008357	intermolecular recognition site; other site
220341008358	dimerization interface [polypeptide binding]; other site
220341008359	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
220341008360	Walker A motif; other site
220341008361	ATP binding site [chemical binding]; other site
220341008362	Walker B motif; other site
220341008363	arginine finger; other site
220341008364	PS00688 Sigma-54 interaction domain C-terminal part signature
220341008365	PS00676 Sigma-54 interaction domain ATP-binding region B signature
220341008366	PS00675 Sigma-54 interaction domain ATP-binding region A signature
220341008367	hypothetical protein; Provisional; Region: PRK10722
220341008368	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341008369	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
220341008370	HAMP domain; Region: HAMP; pfam00672
220341008371	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
220341008372	dimer interface [polypeptide binding]; other site
220341008373	phosphorylation site [posttranslational modification]
220341008374	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
220341008375	ATP binding site [chemical binding]; other site
220341008376	Mg2+ binding site [ion binding]; other site
220341008377	G-X-G motif; other site
220341008378	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
220341008379	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
220341008380	dimerization interface [polypeptide binding]; other site
220341008381	ATP binding site [chemical binding]; other site
220341008382	Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of...; Region: PurL; cd02193
220341008383	dimerization interface [polypeptide binding]; other site
220341008384	ATP binding site [chemical binding]; other site
220341008385	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
220341008386	putative active site [active]
220341008387	catalytic triad [active]
220341008388	PS00922 Prokaryotic transglycosylases signature
220341008389	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
220341008390	nucleoside/Zn binding site; other site
220341008391	dimer interface [polypeptide binding]; other site
220341008392	catalytic motif [active]
220341008393	PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature
220341008394	hypothetical protein; Provisional; Region: PRK11590
220341008395	PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586
220341008396	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
220341008397	active site turn [active]
220341008398	phosphorylation site [posttranslational modification]
220341008399	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
220341008400	PS01035 PTS EIIB domains cysteine phosphorylation site signature
220341008401	N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274
220341008402	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
220341008403	putative active site [active]
220341008404	PS01272 Glucokinase regulatory protein family signature
220341008405	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
220341008406	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557
220341008407	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
220341008408	putative active site [active]
220341008409	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
220341008410	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
220341008411	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
220341008412	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
220341008413	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341008414	putative substrate translocation pore; other site
220341008415	Transcriptional regulator [Transcription]; Region: LysR; COG0583
220341008416	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341008417	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
220341008418	dimerization interface [polypeptide binding]; other site
220341008419	PS00044 Bacterial regulatory proteins, lysR family signature
220341008420	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
220341008421	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341008422	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
220341008423	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
220341008424	active site
220341008425	hydrophilic channel; other site
220341008426	dimerization interface [polypeptide binding]; other site
220341008427	catalytic residues [active]
220341008428	active site lid [active]
220341008429	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
220341008430	Recombination protein O N terminal; Region: RecO_N; pfam11967
220341008431	Recombination protein O C terminal; Region: RecO_C; pfam02565
220341008432	GTPase Era; Reviewed; Region: era; PRK00089
220341008433	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
220341008434	G1 box; other site
220341008435	GTP/Mg2+ binding site [chemical binding]; other site
220341008436	Switch I region; other site
220341008437	G2 box; other site
220341008438	Switch II region; other site
220341008439	G3 box; other site
220341008440	G4 box; other site
220341008441	G5 box; other site
220341008442	KH domain; Region: KH_2; pfam07650
220341008443	PS00017 ATP/GTP-binding site motif A (P-loop)
220341008444	ribonuclease III; Reviewed; Region: rnc; PRK00102
220341008445	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
220341008446	dimerization interface [polypeptide binding]; other site
220341008447	active site
220341008448	metal binding site [ion binding]; metal-binding site
220341008449	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
220341008450	dsRNA binding site [nucleotide binding]; other site
220341008451	PS00517 Ribonuclease III family signature
220341008452	signal peptidase I; Provisional; Region: PRK10861
220341008453	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
220341008454	Catalytic site [active]
220341008455	PS00761 Signal peptidases I signature 3
220341008456	PS00760 Signal peptidases I lysine active site
220341008457	PS00501 Signal peptidases I serine active site
220341008458	GTP-binding protein LepA; Provisional; Region: PRK05433
220341008459	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
220341008460	G1 box; other site
220341008461	putative GEF interaction site [polypeptide binding]; other site
220341008462	GTP/Mg2+ binding site [chemical binding]; other site
220341008463	Switch I region; other site
220341008464	G2 box; other site
220341008465	G3 box; other site
220341008466	Switch II region; other site
220341008467	G4 box; other site
220341008468	G5 box; other site
220341008469	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
220341008470	Elongation Factor G, domain II; Region: EFG_II; pfam14492
220341008471	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
220341008472	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
220341008473	PS00301 GTP-binding elongation factors signature
220341008474	PS00017 ATP/GTP-binding site motif A (P-loop)
220341008475	SoxR reducing system protein RseC; Provisional; Region: PRK10862
220341008476	anti-sigma E factor; Provisional; Region: rseB; PRK09455
220341008477	anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863
220341008478	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
220341008479	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
220341008480	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
220341008481	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
220341008482	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
220341008483	DNA binding residues [nucleotide binding]
220341008484	PS01063 Sigma-70 factors ECF subfamily signature
220341008485	L-aspartate oxidase; Provisional; Region: PRK09077
220341008486	L-aspartate oxidase; Provisional; Region: PRK06175
220341008487	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
220341008488	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
220341008489	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
220341008490	S-adenosylmethionine binding site [chemical binding]; other site
220341008491	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
220341008492	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
220341008493	ATP binding site [chemical binding]; other site
220341008494	Mg++ binding site [ion binding]; other site
220341008495	motif III; other site
220341008496	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
220341008497	nucleotide binding region [chemical binding]; other site
220341008498	ATP-binding site [chemical binding]; other site
220341008499	PS00017 ATP/GTP-binding site motif A (P-loop)
220341008500	PS00039 DEAD-box subfamily ATP-dependent helicases signature
220341008501	PS00044 Bacterial regulatory proteins, lysR family signature
220341008502	cysteine/O-acetylserine exporter; Provisional; Region: PRK10323
220341008503	autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127
220341008504	PS00850 Glycine radical signature
220341008505	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
220341008506	ligand binding site [chemical binding]; other site
220341008507	active site
220341008508	UGI interface [polypeptide binding]; other site
220341008509	catalytic site [active]
220341008510	PS00130 Uracil-DNA glycosylase signature
220341008511	putative methyltransferase; Provisional; Region: PRK10864
220341008512	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
220341008513	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
220341008514	thioredoxin 2; Provisional; Region: PRK10996
220341008515	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
220341008516	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
220341008517	catalytic residues [active]
220341008518	PS00194 Thioredoxin family active site
220341008519	Uncharacterized conserved protein [Function unknown]; Region: COG3148
220341008520	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
220341008521	CoA binding domain; Region: CoA_binding_2; pfam13380
220341008522	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
220341008523	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
220341008524	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
220341008525	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
220341008526	Coenzyme A binding pocket [chemical binding]; other site
220341008527	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
220341008528	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
220341008529	domain interface [polypeptide binding]; other site
220341008530	putative active site [active]
220341008531	catalytic site [active]
220341008532	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
220341008533	domain interface [polypeptide binding]; other site
220341008534	putative active site [active]
220341008535	catalytic site [active]
220341008536	lipoprotein; Provisional; Region: PRK10759
220341008537	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
220341008538	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341008539	putative substrate translocation pore; other site
220341008540	PS00217 Sugar transport proteins signature 2
220341008541	Domain of unknown function (DUF4385); Region: DUF4385; pfam14328
220341008542	protein disaggregation chaperone; Provisional; Region: PRK10865
220341008543	Clp amino terminal domain; Region: Clp_N; pfam02861
220341008544	Clp amino terminal domain; Region: Clp_N; pfam02861
220341008545	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
220341008546	Walker A motif; other site
220341008547	ATP binding site [chemical binding]; other site
220341008548	Walker B motif; other site
220341008549	arginine finger; other site
220341008550	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
220341008551	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
220341008552	Walker A motif; other site
220341008553	ATP binding site [chemical binding]; other site
220341008554	Walker B motif; other site
220341008555	arginine finger; other site
220341008556	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
220341008557	PS00871 Chaperonins clpA/B signature 2
220341008558	PS00017 ATP/GTP-binding site motif A (P-loop)
220341008559	PS00017 ATP/GTP-binding site motif A (P-loop)
220341008560	PS00870 Chaperonins clpA/B signature 1
220341008561	PS00017 ATP/GTP-binding site motif A (P-loop)
220341008562	hypothetical protein; Provisional; Region: PRK10723
220341008563	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
220341008564	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
220341008565	RNA binding surface [nucleotide binding]; other site
220341008566	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
220341008567	active site
220341008568	PS01129 Rlu family of pseudouridine synthase signature
220341008569	outer membrane biogenesis protein BamD; Provisional; Region: PRK10866
220341008570	Protein of unknown function (DUF3897); Region: DUF3897; cl17494
220341008571	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341008572	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
220341008573	30S subunit binding site; other site
220341008574	bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622
220341008575	Chorismate mutase type II; Region: CM_2; cl00693
220341008576	Prephenate dehydratase; Region: PDT; pfam00800
220341008577	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
220341008578	putative L-Phe binding site [chemical binding]; other site
220341008579	PS00858 Prephenate dehydratase signature 2
220341008580	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
220341008581	bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199
220341008582	Chorismate mutase type II; Region: CM_2; cl00693
220341008583	prephenate dehydrogenase; Validated; Region: PRK08507
220341008584	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
220341008585	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
220341008586	putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966
220341008587	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
220341008588	metal binding site [ion binding]; metal-binding site
220341008589	active site
220341008590	I-site; other site
220341008591	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341008592	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
220341008593	PS01015 Ribosomal protein L19 signature
220341008594	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
220341008595	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
220341008596	RimM N-terminal domain; Region: RimM; pfam01782
220341008597	PRC-barrel domain; Region: PRC; pfam05239
220341008598	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
220341008599	PS00732 Ribosomal protein S16 signature
220341008600	signal recognition particle protein; Provisional; Region: PRK10867
220341008601	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
220341008602	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
220341008603	P loop; other site
220341008604	GTP binding site [chemical binding]; other site
220341008605	Signal peptide binding domain; Region: SRP_SPB; pfam02978
220341008606	PS00300 SRP54-type proteins GTP-binding domain signature
220341008607	PS00017 ATP/GTP-binding site motif A (P-loop)
220341008608	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137
220341008609	hypothetical protein; Provisional; Region: PRK11573
220341008610	Domain of unknown function DUF21; Region: DUF21; pfam01595
220341008611	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
220341008612	Transporter associated domain; Region: CorC_HlyC; smart01091
220341008613	Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; cl19511
220341008614	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
220341008615	dimer interface [polypeptide binding]; other site
220341008616	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
220341008617	PS01071 grpE protein signature
220341008618	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378
220341008619	recombination and repair protein; Provisional; Region: PRK10869
220341008620	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
220341008621	Walker A/P-loop; other site
220341008622	ATP binding site [chemical binding]; other site
220341008623	Q-loop/lid; other site
220341008624	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
220341008625	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
220341008626	ABC transporter signature motif; other site
220341008627	Walker B; other site
220341008628	D-loop; other site
220341008629	H-loop/switch region; other site
220341008630	PS00017 ATP/GTP-binding site motif A (P-loop)
220341008631	outer membrane biogenesis protein BamE; Provisional; Region: PRK11548
220341008632	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341008633	hypothetical protein; Validated; Region: PRK01777
220341008634	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
220341008635	putative coenzyme Q binding site [chemical binding]; other site
220341008636	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
220341008637	SmpB-tmRNA interface; other site
220341008638	PS01317 Protein smpB signature
220341008639	Salmonella pathogencity island 9. This region carries CDS which share a significant level of sequence identity with those carried on SPI-4 4321942..4346613
220341008640	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
220341008641	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341008642	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341008643	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341008644	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341008645	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341008646	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341008647	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341008648	Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750
220341008649	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341008650	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
220341008651	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341008652	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341008653	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
220341008654	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341008655	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
220341008656	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341008657	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
220341008658	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341008659	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341008660	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
220341008661	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341008662	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341008663	Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750
220341008664	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
220341008665	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
220341008666	Outer membrane efflux protein; Region: OEP; pfam02321
220341008667	Outer membrane efflux protein; Region: OEP; pfam02321
220341008668	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
220341008669	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
220341008670	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
220341008671	Walker A/P-loop; other site
220341008672	ATP binding site [chemical binding]; other site
220341008673	Q-loop/lid; other site
220341008674	ABC transporter signature motif; other site
220341008675	Walker B; other site
220341008676	D-loop; other site
220341008677	H-loop/switch region; other site
220341008678	PS00017 ATP/GTP-binding site motif A (P-loop)
220341008679	PS00017 ATP/GTP-binding site motif A (P-loop)
220341008680	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
220341008681	HlyD family secretion protein; Region: HlyD_3; pfam13437
220341008682	PS00543 HlyD family secretion proteins signature
220341008683	lysogenic bacteriophage
220341008684	Ogr/Delta-like zinc finger; Region: Ogr_Delta; cl19592
220341008685	tail protein; Provisional; Region: D; PHA02561
220341008686	Phage protein U [General function prediction only]; Region: COG3499
220341008687	Phage-related tail protein [Function unknown]; Region: COG5283
220341008688	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050
220341008689	Phage P2 GpE; Region: Phage_P2_GpE; pfam06528
220341008690	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
220341008691	major tail tube protein; Provisional; Region: FII; PHA02600
220341008692	major tail sheath protein; Provisional; Region: FI; PHA02560
220341008693	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
220341008694	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
220341008695	catalytic residues [active]
220341008696	catalytic nucleophile [active]
220341008697	Presynaptic Site I dimer interface [polypeptide binding]; other site
220341008698	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
220341008699	Synaptic Flat tetramer interface [polypeptide binding]; other site
220341008700	Synaptic Site I dimer interface [polypeptide binding]; other site
220341008701	DNA binding site [nucleotide binding]
220341008702	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569
220341008703	DNA-binding interface [nucleotide binding]; DNA binding site
220341008704	PS00398 Site-specific recombinases signature 2
220341008705	PS00397 Site-specific recombinases active site
220341008706	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
220341008707	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
220341008708	homodimer interface [polypeptide binding]; other site
220341008709	active site
220341008710	TDP-binding site; other site
220341008711	acceptor substrate-binding pocket; other site
220341008712	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
220341008713	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
220341008714	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
220341008715	Walker A/P-loop; other site
220341008716	ATP binding site [chemical binding]; other site
220341008717	Q-loop/lid; other site
220341008718	ABC transporter signature motif; other site
220341008719	Walker B; other site
220341008720	D-loop; other site
220341008721	H-loop/switch region; other site
220341008722	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
220341008723	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
220341008724	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
220341008725	Walker A/P-loop; other site
220341008726	ATP binding site [chemical binding]; other site
220341008727	Q-loop/lid; other site
220341008728	ABC transporter signature motif; other site
220341008729	Walker B; other site
220341008730	D-loop; other site
220341008731	H-loop/switch region; other site
220341008732	PS00017 ATP/GTP-binding site motif A (P-loop)
220341008733	PS00211 ABC transporters family signature
220341008734	PS00017 ATP/GTP-binding site motif A (P-loop)
220341008735	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
220341008736	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
220341008737	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187
220341008738	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
220341008739	outer membrane receptor FepA; Provisional; Region: PRK13528
220341008740	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
220341008741	N-terminal plug; other site
220341008742	ligand-binding site [chemical binding]; other site
220341008743	PS01156 TonB-dependent receptor proteins signature 2
220341008744	PS00449 ATP synthase a subunit signature
220341008745	secreted effector protein PipB2; Provisional; Region: PRK15196
220341008746	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
220341008747	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
220341008748	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
220341008749	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
220341008750	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
220341008751	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990
220341008752	antimicrobial resistance protein Mig-14; Provisional; Region: PRK15312
220341008753	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
220341008754	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
220341008755	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
220341008756	dimer interface [polypeptide binding]; other site
220341008757	phosphorylation site [posttranslational modification]
220341008758	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
220341008759	ATP binding site [chemical binding]; other site
220341008760	Mg2+ binding site [ion binding]; other site
220341008761	G-X-G motif; other site
220341008762	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
220341008763	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
220341008764	active site
220341008765	phosphorylation site [posttranslational modification]
220341008766	intermolecular recognition site; other site
220341008767	dimerization interface [polypeptide binding]; other site
220341008768	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
220341008769	DNA binding site [nucleotide binding]
220341008770	PS00217 Sugar transport proteins signature 2
220341008771	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
220341008772	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
220341008773	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
220341008774	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250
220341008775	substrate binding pocket [chemical binding]; other site
220341008776	active site
220341008777	iron coordination sites [ion binding]; other site
220341008778	hydroxyglutarate oxidase; Provisional; Region: PRK11728
220341008779	Predicted dehydrogenase [General function prediction only]; Region: COG0579
220341008780	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
220341008781	tetramerization interface [polypeptide binding]; other site
220341008782	NAD(P) binding site [chemical binding]; other site
220341008783	catalytic residues [active]
220341008784	PS00687 Aldehyde dehydrogenases glutamic acid active site
220341008785	PS00070 Aldehyde dehydrogenases cysteine active site
220341008786	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
220341008787	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
220341008788	inhibitor-cofactor binding pocket; inhibition site
220341008789	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341008790	catalytic residue [active]
220341008791	PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site
220341008792	gamma-aminobutyrate transporter; Provisional; Region: PRK10197
220341008793	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
220341008794	PS00218 Amino acid permeases signature
220341008795	PS00017 ATP/GTP-binding site motif A (P-loop)
220341008796	DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534
220341008797	helix_turn_helix gluconate operon transcriptional repressor; Region: HTH_GNTR; smart00345
220341008798	DNA-binding site [nucleotide binding]; DNA binding site
220341008799	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
220341008800	PS00043 Bacterial regulatory proteins, gntR family signature
220341008801	Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401
220341008802	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
220341008803	dimerization interface [polypeptide binding]; other site
220341008804	putative DNA binding site [nucleotide binding]; other site
220341008805	putative Zn2+ binding site [ion binding]; other site
220341008806	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
220341008807	active site residue [active]
220341008808	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
220341008809	Domain in histone-like proteins of HNS family; Region: HNS; cl19571
220341008810	DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328
220341008811	Protein of unknown function (DUF1144); Region: DUF1144; pfam06610
220341008812	hypothetical protein; Provisional; Region: PRK10556
220341008813	hypothetical protein; Provisional; Region: PRK10132
220341008814	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
220341008815	Uncharacterized conserved protein [Function unknown]; Region: COG2128
220341008816	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
220341008817	catalytic residues [active]
220341008818	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
220341008819	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
220341008820	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
220341008821	Class I ribonucleotide reductase; Region: RNR_I; cd01679
220341008822	active site
220341008823	dimer interface [polypeptide binding]; other site
220341008824	catalytic residues [active]
220341008825	effector binding site; other site
220341008826	R2 peptide binding site; other site
220341008827	PS00089 Ribonucleotide reductase large subunit signature
220341008828	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
220341008829	dimer interface [polypeptide binding]; other site
220341008830	putative radical transfer pathway; other site
220341008831	diiron center [ion binding]; other site
220341008832	tyrosyl radical; other site
220341008833	PS00368 Ribonucleotide reductase small subunit signature
220341008834	PS00017 ATP/GTP-binding site motif A (P-loop)
220341008835	PS00211 ABC transporters family signature
220341008836	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
220341008837	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341008838	dimer interface [polypeptide binding]; other site
220341008839	conserved gate region; other site
220341008840	putative PBP binding loops; other site
220341008841	ABC-ATPase subunit interface; other site
220341008842	PS00402 Binding-protein-dependent transport systems inner membrane comp sign.
220341008843	glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119
220341008844	PS00017 ATP/GTP-binding site motif A (P-loop)
220341008845	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
220341008846	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341008847	putative substrate translocation pore; other site
220341008848	PS00017 ATP/GTP-binding site motif A (P-loop)
220341008849	transcriptional repressor MprA; Provisional; Region: PRK10870
220341008850	Transcriptional regulators [Transcription]; Region: MarR; COG1846
220341008851	PS01117 Bacterial regulatory proteins, marR family signature
220341008852	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
220341008853	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
220341008854	HlyD family secretion protein; Region: HlyD_3; pfam13437
220341008855	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
220341008856	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341008857	putative substrate translocation pore; other site
220341008858	Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471
220341008859	S-ribosylhomocysteinase; Provisional; Region: PRK02260
220341008860	glutamate--cysteine ligase; Provisional; Region: PRK02107
220341008861	Predicted membrane protein [Function unknown]; Region: COG1238
220341008862	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
220341008863	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
220341008864	active site
220341008865	motif I; other site
220341008866	motif II; other site
220341008867	carbon storage regulator; Provisional; Region: PRK01712
220341008868	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
220341008869	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
220341008870	motif 1; other site
220341008871	active site
220341008872	motif 2; other site
220341008873	motif 3; other site
220341008874	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
220341008875	DHHA1 domain; Region: DHHA1; pfam02272
220341008876	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2
220341008877	recombination regulator RecX; Reviewed; Region: recX; PRK00117
220341008878	recombinase A; Provisional; Region: recA; PRK09354
220341008879	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
220341008880	hexamer interface [polypeptide binding]; other site
220341008881	Walker A motif; other site
220341008882	ATP binding site [chemical binding]; other site
220341008883	Walker B motif; other site
220341008884	PS00321 recA signature
220341008885	PS00017 ATP/GTP-binding site motif A (P-loop)
220341008886	PS00017 ATP/GTP-binding site motif A (P-loop)
220341008887	hypothetical protein; Validated; Region: PRK03661
220341008888	murein hydrolase B; Provisional; Region: PRK10760
220341008889	lytic murein transglycosylase B; Region: MltB; TIGR02282
220341008890	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
220341008891	N-acetyl-D-glucosamine binding site [chemical binding]; other site
220341008892	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341008893	PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821
220341008894	Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732
220341008895	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
220341008896	Nucleoside recognition; Region: Gate; pfam07670
220341008897	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
220341008898	PS00107 Protein kinases ATP-binding region signature
220341008899	PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377
220341008900	sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384
220341008901	Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322
220341008902	putative NAD(P) binding site [chemical binding]; other site
220341008903	active site
220341008904	PS00061 Short-chain dehydrogenases/reductases family signature
220341008905	DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234
220341008906	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
220341008907	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
220341008908	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
220341008909	PS00894 Bacterial regulatory proteins, deoR family signature
220341008910	D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543
220341008911	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
220341008912	putative active site [active]
220341008913	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
220341008914	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
220341008915	GAF domain; Region: GAF; pfam01590
220341008916	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
220341008917	Walker A motif; other site
220341008918	ATP binding site [chemical binding]; other site
220341008919	Walker B motif; other site
220341008920	arginine finger; other site
220341008921	PS00688 Sigma-54 interaction domain C-terminal part signature
220341008922	PS00676 Sigma-54 interaction domain ATP-binding region B signature
220341008923	PS00675 Sigma-54 interaction domain ATP-binding region A signature
220341008924	anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452
220341008925	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
220341008926	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
220341008927	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
220341008928	iron binding site [ion binding]; other site
220341008929	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
220341008930	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
220341008931	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
220341008932	Acylphosphatase; Region: Acylphosphatase; pfam00708
220341008933	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
220341008934	HypF finger; Region: zf-HYPF; pfam07503
220341008935	HypF finger; Region: zf-HYPF; pfam07503
220341008936	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
220341008937	PS00150 Acylphosphatase signature 1
220341008938	formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330
220341008939	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
220341008940	PS00190 Cytochrome c family heme-binding site signature
220341008941	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341008942	Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067
220341008943	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
220341008944	nickel binding site [ion binding]; other site
220341008945	formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084
220341008946	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
220341008947	PS01150 Respiratory-chain NADH dehydrogenase 20 Kd subunit signature
220341008948	formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387
220341008949	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
220341008950	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341008951	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341008952	Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262
220341008953	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
220341008954	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
220341008955	PS00535 Respiratory chain NADH dehydrogenase 49 Kd subunit signature
220341008956	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
220341008957	PS00668 Respiratory-chain NADH dehydrogenase subunit 1 signature 2
220341008958	PS00667 Respiratory-chain NADH dehydrogenase subunit 1 signature 1
220341008959	formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042
220341008960	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
220341008961	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
220341008962	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
220341008963	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
220341008964	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341008965	PS00190 Cytochrome c family heme-binding site signature
220341008966	formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198
220341008967	hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681
220341008968	PS01249 Hydrogenases expression/synthesis hypA family signature
220341008969	hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463
220341008970	hydrogenase assembly chaperone; Provisional; Region: PRK10409
220341008971	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
220341008972	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
220341008973	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
220341008974	dimerization interface [polypeptide binding]; other site
220341008975	ATP binding site [chemical binding]; other site
220341008976	formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429
220341008977	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
220341008978	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
220341008979	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
220341008980	Walker A motif; other site
220341008981	ATP binding site [chemical binding]; other site
220341008982	Walker B motif; other site
220341008983	arginine finger; other site
220341008984	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
220341008985	PS00688 Sigma-54 interaction domain C-terminal part signature
220341008986	Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756
220341008987	Salmonella Pathogenicity Island 1. This island carries multiple virulence determinants for adhesion and entry into cells
220341008988	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
220341008989	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
220341008990	metal binding site [ion binding]; metal-binding site
220341008991	manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056
220341008992	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
220341008993	PS00017 ATP/GTP-binding site motif A (P-loop)
220341008994	PS00211 ABC transporters family signature
220341008995	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
220341008996	ABC-ATPase subunit  interface; other site
220341008997	dimer interface [polypeptide binding]; other site
220341008998	putative PBP binding regions; other site
220341008999	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
220341009000	ABC-ATPase subunit  interface; other site
220341009001	dimer interface [polypeptide binding]; other site
220341009002	putative PBP binding regions; other site
220341009003	transcriptional activator SprB; Provisional; Region: PRK15320
220341009004	transcriptional regulator SirC; Provisional; Region: PRK15044
220341009005	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341009006	PS00041 Bacterial regulatory proteins, araC family signature
220341009007	putative type III secretion system effector protein OrgC; Provisional; Region: PRK15321
220341009008	invasion protein OrgB; Provisional; Region: PRK15322
220341009009	invasion protein OrgA; Provisional; Region: PRK15323
220341009010	type III secretion system lipoprotein PrgK; Provisional; Region: PRK15324
220341009011	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341009012	type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325
220341009013	type III secretion system needle complex protein PrgI; Provisional; Region: PRK15326
220341009014	type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327
220341009015	transcriptional regulator HilD; Provisional; Region: PRK15185
220341009016	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341009017	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341009018	PS00041 Bacterial regulatory proteins, araC family signature
220341009019	invasion protein regulator; Provisional; Region: PRK12370
220341009020	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
220341009021	DNA binding site [nucleotide binding]
220341009022	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
220341009023	binding surface
220341009024	TPR motif; other site
220341009025	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
220341009026	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
220341009027	N-acetyl-D-glucosamine binding site [chemical binding]; other site
220341009028	catalytic residue [active]
220341009029	pathogenicity island 1 effector protein StpP; Provisional; Region: PRK15375
220341009030	SicP binding; Region: SicP-binding; pfam09119
220341009031	GTPase-activating protein (GAP) domain found in bacterial cytotoxins, ExoS, SptP, and YopE. Part of protein secretion system; stimulates Rac1- dependent cytoskeletal changes that promote bacterial internalization; Region: ToxGAP; cd00219
220341009032	switch II binding region; other site
220341009033	Rac1 P-loop interaction site [polypeptide binding]; other site
220341009034	GTP binding residues [chemical binding]; other site
220341009035	switch I binding region; other site
220341009036	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047
220341009037	active site
220341009038	PS00383 Tyrosine specific protein phosphatases active site
220341009039	chaperone protein SicP; Provisional; Region: PRK15329
220341009040	putative acyl carrier protein IacP; Validated; Region: PRK08172
220341009041	pathogenicity island 1 effector protein SipA; Provisional; Region: PRK15376
220341009042	cell invasion protein SipD; Provisional; Region: PRK15330
220341009043	pathogenicity island 1 effector protein SipC; Provisional; Region: PRK15373
220341009044	pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374
220341009045	Secretion system effector C (SseC) like family; Region: SseC; pfam04888
220341009046	chaperone protein SicA; Provisional; Region: PRK15331
220341009047	Tetratricopeptide repeat; Region: TPR_3; pfam07720
220341009048	Tetratricopeptide repeat; Region: TPR_3; pfam07720
220341009049	type III secretion system protein SpaS; Validated; Region: PRK08156
220341009050	type III secretion system protein SpaR; Provisional; Region: PRK15332
220341009051	type III secretion system protein SpaQ; Provisional; Region: PRK15333
220341009052	PS00888 Cyclic nucleotide-binding domain signature 1
220341009053	type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796
220341009054	PS01061 Flagella transport protein fliP family signature 2
220341009055	PS01060 Flagella transport protein fliP family signature 1
220341009056	type III secretion system protein SpaO; Validated; Region: PRK08158
220341009057	type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551
220341009058	Surface presentation of antigens protein; Region: SPAN; cl19597
220341009059	Salmonella surface presentation of antigen gene type M protein; Region: SPAM; pfam02090
220341009060	ATP synthase SpaL; Validated; Region: PRK08149
220341009061	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
220341009062	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
220341009063	Walker A motif; other site
220341009064	ATP binding site [chemical binding]; other site
220341009065	Walker B motif; other site
220341009066	PS00152 ATP synthase alpha and beta subunits signature
220341009067	PS00017 ATP/GTP-binding site motif A (P-loop)
220341009068	type III secretion system chaperone SpaK; Provisional; Region: PRK15336
220341009069	type III secretion system protein InvA; Provisional; Region: PRK15337
220341009070	PS00994 Bacterial export FHIPEP family signature
220341009071	type III secretion system regulator InvE; Provisional; Region: PRK15338
220341009072	type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568
220341009073	type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339
220341009074	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
220341009075	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
220341009076	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
220341009077	PS00875 Bacterial type II secretion system protein D signature
220341009078	PS00017 ATP/GTP-binding site motif A (P-loop)
220341009079	transcriptional regulator InvF; Provisional; Region: PRK15340
220341009080	PS00041 Bacterial regulatory proteins, araC family signature
220341009081	InvH outer membrane lipoprotein; Region: InvH; pfam04741
220341009082	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341009083	Insertion element gene fragment which is similar to Salmonella enteritidis insertion sequence IS1230 TR:O34117 (EMBL:U91789) and to an Escherichia coli hypothetical protein found within IS3 TR:P77681 (EMBL:AE000298).
220341009084	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
220341009085	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
220341009086	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
220341009087	PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424
220341009088	active site
220341009089	metal binding site [ion binding]; metal-binding site
220341009090	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
220341009091	MutS domain I; Region: MutS_I; pfam01624
220341009092	MutS domain II; Region: MutS_II; pfam05188
220341009093	MutS domain III; Region: MutS_III; pfam05192
220341009094	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
220341009095	Walker A/P-loop; other site
220341009096	ATP binding site [chemical binding]; other site
220341009097	Q-loop/lid; other site
220341009098	ABC transporter signature motif; other site
220341009099	Walker B; other site
220341009100	D-loop; other site
220341009101	H-loop/switch region; other site
220341009102	PS00017 ATP/GTP-binding site motif A (P-loop)
220341009103	PS00486 DNA mismatch repair proteins mutS family signature
220341009104	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341009105	Major Facilitator Superfamily; Region: MFS_1; pfam07690
220341009106	putative substrate translocation pore; other site
220341009107	PS00217 Sugar transport proteins signature 2
220341009108	PS00041 Bacterial regulatory proteins, araC family signature
220341009109	Transcriptional regulator [Transcription]; Region: LysR; COG0583
220341009110	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341009111	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
220341009112	putative effector binding pocket; other site
220341009113	dimerization interface [polypeptide binding]; other site
220341009114	PS00044 Bacterial regulatory proteins, lysR family signature
220341009115	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
220341009116	GntP family permease; Region: GntP_permease; pfam02447
220341009117	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
220341009118	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
220341009119	putative NAD(P) binding site [chemical binding]; other site
220341009120	active site
220341009121	putative substrate binding site [chemical binding]; other site
220341009122	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
220341009123	hypothetical protein; Provisional; Region: PRK09989
220341009124	putative aldolase; Validated; Region: PRK08130
220341009125	intersubunit interface [polypeptide binding]; other site
220341009126	active site
220341009127	Zn2+ binding site [ion binding]; other site
220341009128	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341009130	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
220341009131	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
220341009132	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
220341009133	PS00894 Bacterial regulatory proteins, deoR family signature
220341009134	Transcriptional regulators [Transcription]; Region: MarR; COG1846
220341009135	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
220341009136	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
220341009137	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
220341009138	Protein of unknown function (DUF1062); Region: DUF1062; cl01786
220341009139	RNA polymerase sigma factor RpoS; Validated; Region: PRK05657
220341009140	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
220341009141	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
220341009142	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
220341009143	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
220341009144	DNA binding residues [nucleotide binding]
220341009145	PS00716 Sigma-70 factors family signature 2
220341009146	PS00715 Sigma-70 factors family signature 1
220341009147	lipoprotein NlpD; Provisional; Region: nlpD; PRK10871
220341009148	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
220341009149	Peptidase family M23; Region: Peptidase_M23; pfam01551
220341009150	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341009151	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
220341009152	S-adenosylmethionine binding site [chemical binding]; other site
220341009153	PS01279 Protein-L-isoaspartate(D-aspartate) O-methyltransferase signature
220341009154	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
220341009155	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
220341009156	Permutation of conserved domain; other site
220341009157	active site
220341009158	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
220341009159	homotrimer interaction site [polypeptide binding]; other site
220341009160	zinc binding site [ion binding]; other site
220341009161	CDP-binding sites; other site
220341009162	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
220341009163	substrate binding site; other site
220341009164	dimer interface; other site
220341009165	PS01295 Uncharacterized protein family UPF0007 signature
220341009166	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
220341009167	Protein of unknown function (DUF3561); Region: DUF3561; pfam12084
220341009168	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
220341009169	ligand-binding site [chemical binding]; other site
220341009170	PS00017 ATP/GTP-binding site motif A (P-loop)
220341009171	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
220341009172	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
220341009173	CysD dimerization site [polypeptide binding]; other site
220341009174	G1 box; other site
220341009175	putative GEF interaction site [polypeptide binding]; other site
220341009176	GTP/Mg2+ binding site [chemical binding]; other site
220341009177	Switch I region; other site
220341009178	G2 box; other site
220341009179	G3 box; other site
220341009180	Switch II region; other site
220341009181	G4 box; other site
220341009182	G5 box; other site
220341009183	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
220341009184	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
220341009185	PS00301 GTP-binding elongation factors signature
220341009186	PS00017 ATP/GTP-binding site motif A (P-loop)
220341009187	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
220341009188	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
220341009189	Active Sites [active]
220341009190	alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199
220341009191	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
220341009192	metal binding site [ion binding]; metal-binding site
220341009193	putative ssRNA endonuclease; Provisional; Region: PRK11558
220341009194	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719
220341009195	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09664
220341009196	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645
220341009197	CT1975-like protein; Region: Cas_CT1975; pfam09344
220341009198	CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09670
220341009199	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669
220341009200	pathogenicity island 1 effector protein SopD; Provisional; Region: PRK15379
220341009201	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
220341009202	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
220341009203	Active Sites [active]
220341009204	sulfite reductase subunit beta; Provisional; Region: PRK13504
220341009205	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
220341009206	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
220341009207	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
220341009208	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
220341009209	PS00365 Nitrite and sulfite reductases iron-sulfur/siroheme-binding site
220341009210	sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953
220341009211	Flavodoxin; Region: Flavodoxin_1; pfam00258
220341009212	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
220341009213	FAD binding pocket [chemical binding]; other site
220341009214	FAD binding motif [chemical binding]; other site
220341009215	catalytic residues [active]
220341009216	NAD binding pocket [chemical binding]; other site
220341009217	phosphate binding motif [ion binding]; other site
220341009218	beta-alpha-beta structure motif; other site
220341009219	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
220341009220	active site
220341009221	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
220341009222	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
220341009223	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
220341009224	enolase; Provisional; Region: eno; PRK00077
220341009225	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
220341009226	dimer interface [polypeptide binding]; other site
220341009227	metal binding site [ion binding]; metal-binding site
220341009228	substrate binding pocket [chemical binding]; other site
220341009229	PS00164 Enolase signature
220341009230	CTP synthetase; Validated; Region: pyrG; PRK05380
220341009231	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
220341009232	Catalytic site [active]
220341009233	active site
220341009234	UTP binding site [chemical binding]; other site
220341009235	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
220341009236	active site
220341009237	putative oxyanion hole; other site
220341009238	catalytic triad [active]
220341009239	PS00442 Glutamine amidotransferases class-I active site
220341009240	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
220341009241	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
220341009242	homodimer interface [polypeptide binding]; other site
220341009243	metal binding site [ion binding]; metal-binding site
220341009244	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
220341009245	homodimer interface [polypeptide binding]; other site
220341009246	active site
220341009247	putative chemical substrate binding site [chemical binding]; other site
220341009248	metal binding site [ion binding]; metal-binding site
220341009249	putative fimbrial outer membrane usher protein SteB; Provisional; Region: PRK15273
220341009250	PapC N-terminal domain; Region: PapC_N; pfam13954
220341009251	Outer membrane usher protein; Region: Usher; pfam00577
220341009252	PapC C-terminal domain; Region: PapC_C; pfam13953
220341009253	PS01151 Fimbrial biogenesis outer membrane usher protein signature
220341009254	putative periplasmic fimbrial chaperone protein SteC; Provisional; Region: PRK15274
220341009255	Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345
220341009256	Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753
220341009257	PS00635 Gram-negative pili assembly chaperone signature
220341009258	putative fimbrial protein SteD; Provisional; Region: PRK15275
220341009259	putative fimbrial subunit SteE; Provisional; Region: PRK15276
220341009260	fimbrial protein SteF; Provisional; Region: PRK15260
220341009261	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
220341009262	(p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872
220341009263	HD domain; Region: HD_4; pfam13328
220341009264	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
220341009265	synthetase active site [active]
220341009266	NTP binding site [chemical binding]; other site
220341009267	metal binding site [ion binding]; metal-binding site
220341009268	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
220341009269	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
220341009270	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
220341009271	TRAM domain; Region: TRAM; pfam01938
220341009272	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
220341009273	S-adenosylmethionine binding site [chemical binding]; other site
220341009274	PS01231 RNA methyltransferase trmA family signature 2
220341009275	PS01230 RNA methyltransferase trmA family signature 1
220341009276	hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107
220341009277	Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984
220341009278	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
220341009279	dimerization interface [polypeptide binding]; other site
220341009280	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
220341009281	dimer interface [polypeptide binding]; other site
220341009282	phosphorylation site [posttranslational modification]
220341009283	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
220341009284	ATP binding site [chemical binding]; other site
220341009285	Mg2+ binding site [ion binding]; other site
220341009286	G-X-G motif; other site
220341009287	Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999
220341009288	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
220341009289	active site
220341009290	phosphorylation site [posttranslational modification]
220341009291	intermolecular recognition site; other site
220341009292	dimerization interface [polypeptide binding]; other site
220341009293	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
220341009294	putative binding surface; other site
220341009295	active site
220341009296	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
220341009297	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
220341009298	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
220341009299	active site
220341009300	tetramer interface [polypeptide binding]; other site
220341009301	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
220341009302	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
220341009303	active site
220341009304	tetramer interface [polypeptide binding]; other site
220341009305	PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1
220341009306	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341009307	D-galactonate transporter; Region: 2A0114; TIGR00893
220341009308	putative substrate translocation pore; other site
220341009309	flavodoxin; Provisional; Region: PRK08105
220341009310	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
220341009311	tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563
220341009312	probable active site [active]
220341009313	PS01129 Rlu family of pseudouridine synthase signature
220341009314	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098
220341009315	SecY interacting protein Syd; Provisional; Region: PRK04968
220341009316	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
220341009317	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
220341009318	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
220341009319	Domain of unknown function (DUF4478); Region: DUF4478; pfam14793
220341009320	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
220341009321	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
220341009322	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
220341009323	serine transporter; Region: stp; TIGR00814
220341009324	L-serine dehydratase TdcG; Provisional; Region: PRK15040
220341009325	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
220341009326	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
220341009327	flap endonuclease-like protein; Provisional; Region: PRK09482
220341009328	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
220341009329	active site
220341009330	metal binding site 1 [ion binding]; metal-binding site
220341009331	putative 5' ssDNA interaction site; other site
220341009332	metal binding site 3; metal-binding site
220341009333	metal binding site 2 [ion binding]; metal-binding site
220341009334	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
220341009335	putative DNA binding site [nucleotide binding]; other site
220341009336	putative metal binding site [ion binding]; other site
220341009337	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
220341009338	dimer interface [polypeptide binding]; other site
220341009339	active site
220341009340	metal binding site [ion binding]; metal-binding site
220341009341	PS00060 Iron-containing alcohol dehydrogenases signature 2
220341009342	PS00913 Iron-containing alcohol dehydrogenases signature 1
220341009343	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
220341009344	intersubunit interface [polypeptide binding]; other site
220341009345	active site
220341009346	Zn2+ binding site [ion binding]; other site
220341009347	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
220341009348	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341009349	putative substrate translocation pore; other site
220341009350	L-fucose isomerase; Provisional; Region: fucI; PRK10991
220341009351	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
220341009352	hexamer (dimer of trimers) interface [polypeptide binding]; other site
220341009353	trimer interface [polypeptide binding]; other site
220341009354	substrate binding site [chemical binding]; other site
220341009355	Mn binding site [ion binding]; other site
220341009356	L-fuculokinase; Provisional; Region: PRK10331
220341009357	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
220341009358	nucleotide binding site [chemical binding]; other site
220341009359	PS00933 FGGY family of carbohydrate kinases signature 1
220341009360	PS00445 FGGY family of carbohydrate kinases signature 2
220341009361	L-fucose mutarotase; Provisional; Region: fucU; PRK15420
220341009362	DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411
220341009363	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
220341009364	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
220341009365	PS00894 Bacterial regulatory proteins, deoR family signature
220341009366	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
220341009367	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
220341009368	hypothetical protein; Provisional; Region: PRK10873
220341009369	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
220341009370	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341009371	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
220341009372	dimerization interface [polypeptide binding]; other site
220341009373	substrate binding pocket [chemical binding]; other site
220341009374	PS00044 Bacterial regulatory proteins, lysR family signature
220341009375	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
220341009376	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341009377	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
220341009378	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
220341009379	catalytic residue [active]
220341009380	PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site
220341009381	CsdA-binding activator; Provisional; Region: PRK15019
220341009382	Predicted permeases [General function prediction only]; Region: RarD; COG2962
220341009383	sulfur acceptor protein CsdL; Provisional; Region: PRK15116
220341009384	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
220341009385	putative ATP binding site [chemical binding]; other site
220341009386	putative substrate interface [chemical binding]; other site
220341009387	murein transglycosylase A; Provisional; Region: mltA; PRK11162
220341009388	MltA specific insert domain; Region: MltA; smart00925
220341009389	3D domain; Region: 3D; pfam06725
220341009390	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341009391	AMIN domain; Region: AMIN; pfam11741
220341009392	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
220341009393	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
220341009394	active site
220341009395	metal binding site [ion binding]; metal-binding site
220341009396	N-acetylglutamate synthase; Validated; Region: PRK05279
220341009397	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
220341009398	putative feedback inhibition sensing region; other site
220341009399	putative nucleotide binding site [chemical binding]; other site
220341009400	putative substrate binding site [chemical binding]; other site
220341009401	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
220341009402	Coenzyme A binding pocket [chemical binding]; other site
220341009403	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
220341009404	AAA domain; Region: AAA_30; pfam13604
220341009405	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
220341009406	PS00017 ATP/GTP-binding site motif A (P-loop)
220341009407	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
220341009408	Protein of unknown function (DUF770); Region: DUF770; cl01402
220341009409	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
220341009410	PS00017 ATP/GTP-binding site motif A (P-loop)
220341009411	protease3; Provisional; Region: PRK15101
220341009412	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
220341009413	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
220341009414	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
220341009415	Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330
220341009416	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
220341009417	hypothetical protein; Provisional; Region: PRK10332
220341009418	Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967
220341009419	PS00409 Prokaryotic N-terminal methylation site
220341009420	hypothetical protein; Provisional; Region: PRK11521
220341009421	hypothetical protein; Provisional; Region: PRK10557
220341009422	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
220341009423	PS00409 Prokaryotic N-terminal methylation site
220341009424	hypothetical protein; Provisional; Region: PRK10506
220341009425	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
220341009426	PS00409 Prokaryotic N-terminal methylation site
220341009427	Transposase IS200 like; Region: Y1_Tnp; pfam01797
220341009428	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
220341009429	dimerization interface [polypeptide binding]; other site
220341009430	active site
220341009431	PS00091 Thymidylate synthase active site
220341009432	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
220341009433	PS01311 Prolipoprotein diacylglyceryl transferase signature
220341009434	fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061
220341009435	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
220341009436	PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524
220341009437	PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391
220341009438	PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
220341009439	PS00742 PEP-utilizing enzymes signature 2
220341009440	PS00370 PEP-utilizing enzymes phosphorylation site signature
220341009441	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
220341009442	putative active site [active]
220341009443	Ap4A binding site [chemical binding]; other site
220341009444	nudix motif; other site
220341009445	putative metal binding site [ion binding]; other site
220341009446	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
220341009447	putative DNA-binding cleft [nucleotide binding]; other site
220341009448	putative DNA clevage site; other site
220341009449	molecular lever; other site
220341009450	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
220341009451	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
220341009452	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341009453	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
220341009454	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
220341009455	active site
220341009456	catalytic tetrad [active]
220341009457	lysophospholipid transporter LplT; Provisional; Region: PRK11195
220341009458	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341009459	putative substrate translocation pore; other site
220341009460	bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043
220341009461	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
220341009462	putative acyl-acceptor binding pocket; other site
220341009463	C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909
220341009464	acyl-activating enzyme (AAE) consensus motif; other site
220341009465	putative AMP binding site [chemical binding]; other site
220341009466	PS00455 Putative AMP-binding domain signature
220341009467	Transposase IS200 like; Region: Y1_Tnp; pfam01797
220341009468	DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727
220341009469	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
220341009470	DNA binding site [nucleotide binding]
220341009471	domain linker motif; other site
220341009472	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
220341009473	dimerization interface (closed form) [polypeptide binding]; other site
220341009474	ligand binding site [chemical binding]; other site
220341009475	PS00356 Bacterial regulatory proteins, lacI family signature
220341009476	Transcriptional regulators [Transcription]; Region: PurR; COG1609
220341009477	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
220341009478	DNA binding site [nucleotide binding]
220341009479	domain linker motif; other site
220341009480	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
220341009481	dimerization interface (closed form) [polypeptide binding]; other site
220341009482	ligand binding site [chemical binding]; other site
220341009483	diaminopimelate decarboxylase; Provisional; Region: PRK11165
220341009484	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
220341009485	active site
220341009486	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
220341009487	substrate binding site [chemical binding]; other site
220341009488	catalytic residues [active]
220341009489	dimer interface [polypeptide binding]; other site
220341009490	PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2
220341009491	PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site
220341009492	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
220341009493	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341009494	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
220341009495	dimerization interface [polypeptide binding]; other site
220341009496	PS00044 Bacterial regulatory proteins, lysR family signature
220341009497	putative racemase; Provisional; Region: PRK10200
220341009498	PS00924 Aspartate and glutamate racemases signature 2
220341009499	PS00923 Aspartate and glutamate racemases signature 1
220341009500	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
220341009501	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341009502	putative substrate translocation pore; other site
220341009503	PS00216 Sugar transport proteins signature 1
220341009504	PS00217 Sugar transport proteins signature 2
220341009505	2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993
220341009506	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
220341009507	NADP binding site [chemical binding]; other site
220341009508	homodimer interface [polypeptide binding]; other site
220341009509	active site
220341009510	PS00061 Short-chain dehydrogenases/reductases family signature
220341009511	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
220341009512	putative acyltransferase; Provisional; Region: PRK05790
220341009513	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
220341009514	dimer interface [polypeptide binding]; other site
220341009515	active site
220341009516	PS00099 Thiolases active site
220341009517	PS00737 Thiolases signature 2
220341009518	PS00098 Thiolases acyl-enzyme intermediate signature
220341009519	Transcriptional regulator [Transcription]; Region: LysR; COG0583
220341009520	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341009521	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
220341009522	dimerization interface [polypeptide binding]; other site
220341009523	Predicted membrane protein [Function unknown]; Region: COG4125
220341009524	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
220341009525	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
220341009526	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
220341009527	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
220341009528	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341009529	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
220341009530	putative metal binding site [ion binding]; other site
220341009531	putative homodimer interface [polypeptide binding]; other site
220341009532	putative homotetramer interface [polypeptide binding]; other site
220341009533	putative homodimer-homodimer interface [polypeptide binding]; other site
220341009534	putative allosteric switch controlling residues; other site
220341009535	transcriptional activator SprB; Provisional; Region: PRK15320
220341009536	Protein of unknown function (DUF1401); Region: DUF1401; pfam07180
220341009537	low G+C region
220341009538	Fimbrial protein; Region: Fimbrial; pfam00419
220341009539	fimbrial chaperone protein StdC; Provisional; Region: PRK15254
220341009540	Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345
220341009541	Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753
220341009542	PS00635 Gram-negative pili assembly chaperone signature
220341009543	fimbrial outer membrane usher protein StdB; Provisional; Region: PRK15255
220341009544	PapC N-terminal domain; Region: PapC_N; pfam13954
220341009545	Outer membrane usher protein; Region: Usher; pfam00577
220341009546	PapC C-terminal domain; Region: PapC_C; pfam13953
220341009547	PS00017 ATP/GTP-binding site motif A (P-loop)
220341009548	PS01151 Fimbrial biogenesis outer membrane usher protein signature
220341009549	fimbrial protein StdA; Provisional; Region: PRK15210
220341009550	Low G+C region
220341009551	hypothetical protein; Provisional; Region: PRK10316
220341009552	YfdX protein; Region: YfdX; pfam10938
220341009553	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
220341009554	PS00695 Enterobacterial virulence outer membrane protein signature 2
220341009555	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
220341009556	oligomeric interface; other site
220341009557	putative active site [active]
220341009558	homodimer interface [polypeptide binding]; other site
220341009559	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
220341009560	Protein of unknown function (DUF1460); Region: DUF1460; pfam07313
220341009561	INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184
220341009562	Int/Topo IB signature motif; other site
220341009563	lipoprotein NlpD; Provisional; Region: nlpD; PRK10871
220341009564	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
220341009565	Peptidase family M23; Region: Peptidase_M23; pfam01551
220341009566	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341009567	Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443
220341009568	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
220341009569	active site
220341009570	metal binding site [ion binding]; metal-binding site
220341009571	nudix motif; other site
220341009572	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
220341009573	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
220341009574	dimer interface [polypeptide binding]; other site
220341009575	putative anticodon binding site; other site
220341009576	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
220341009577	motif 1; other site
220341009578	active site
220341009579	motif 2; other site
220341009580	motif 3; other site
220341009581	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2
220341009582	PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1
220341009583	peptide chain release factor 2; Validated; Region: prfB; PRK00578
220341009584	This domain is found in peptide chain release factors; Region: PCRF; smart00937
220341009585	RF-1 domain; Region: RF-1; pfam00472
220341009586	PS00745 Prokaryotic-type class I peptide chain release factors signature
220341009587	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
220341009588	DHH family; Region: DHH; pfam01368
220341009589	DHHA1 domain; Region: DHHA1; pfam02272
220341009590	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
220341009591	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
220341009592	dimerization domain [polypeptide binding]; other site
220341009593	dimer interface [polypeptide binding]; other site
220341009594	catalytic residues [active]
220341009595	PS00194 Thioredoxin family active site
220341009596	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
220341009597	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
220341009598	active site
220341009599	Int/Topo IB signature motif; other site
220341009600	flavodoxin FldB; Provisional; Region: PRK12359
220341009601	PS00201 Flavodoxin signature
220341009602	hypothetical protein; Provisional; Region: PRK10878
220341009603	putative global regulator; Reviewed; Region: PRK09559
220341009604	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
220341009605	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
220341009606	hemolysin; Provisional; Region: PRK15087
220341009607	ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552
220341009608	6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014
220341009609	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232
220341009610	PS00653 Glycosyl hydrolases family 1 N-terminal signature
220341009611	PS00572 Glycosyl hydrolases family 1 active site
220341009612	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
220341009613	glycine dehydrogenase; Provisional; Region: PRK05367
220341009614	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
220341009615	tetramer interface [polypeptide binding]; other site
220341009616	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341009617	catalytic residue [active]
220341009618	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
220341009619	tetramer interface [polypeptide binding]; other site
220341009620	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341009621	catalytic residue [active]
220341009622	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
220341009623	lipoyl attachment site [posttranslational modification]; other site
220341009624	PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site
220341009625	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
220341009626	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
220341009627	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
220341009628	oxidoreductase; Provisional; Region: PRK08013
220341009629	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
220341009630	PS01304 ubiH/COQ6 monooxygenase family signature
220341009631	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732
220341009632	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
220341009633	PS01304 ubiH/COQ6 monooxygenase family signature
220341009634	proline aminopeptidase P II; Provisional; Region: PRK10879
220341009635	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
220341009636	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
220341009637	active site
220341009638	PS00491 Aminopeptidase P and proline dipeptidase signature
220341009639	hypothetical protein; Reviewed; Region: PRK01736
220341009640	Z-ring-associated protein; Provisional; Region: PRK10972
220341009641	5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333
220341009642	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
220341009643	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
220341009644	ligand binding site [chemical binding]; other site
220341009645	NAD binding site [chemical binding]; other site
220341009646	tetramer interface [polypeptide binding]; other site
220341009647	catalytic site [active]
220341009648	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
220341009649	L-serine binding site [chemical binding]; other site
220341009650	ACT domain interface; other site
220341009651	PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3
220341009652	PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2
220341009653	PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature
220341009654	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
220341009655	tetramer (dimer of dimers) interface [polypeptide binding]; other site
220341009656	active site
220341009657	dimer interface [polypeptide binding]; other site
220341009658	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
220341009659	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341009660	The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428
220341009661	putative dimerization interface [polypeptide binding]; other site
220341009662	PS00044 Bacterial regulatory proteins, lysR family signature
220341009663	oxidative stress defense protein; Provisional; Region: PRK11087
220341009664	arginine exporter protein; Provisional; Region: PRK09304
220341009665	mechanosensitive channel MscS; Provisional; Region: PRK10334
220341009666	Mechanosensitive ion channel; Region: MS_channel; pfam00924
220341009667	PS01246 Uncharacterized protein family UPF0003 signature
220341009668	IS200
220341009669	Transposase IS200 like; Region: Y1_Tnp; pfam01797
220341009670	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
220341009671	active site
220341009672	intersubunit interface [polypeptide binding]; other site
220341009673	zinc binding site [ion binding]; other site
220341009674	Na+ binding site [ion binding]; other site
220341009675	PS00806 Fructose-bisphosphate aldolase class-II signature 2
220341009676	PS00602 Fructose-bisphosphate aldolase class-II signature 1
220341009677	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
220341009678	substrate binding site [chemical binding]; other site
220341009679	hinge regions; other site
220341009680	ADP binding site [chemical binding]; other site
220341009681	catalytic site [active]
220341009682	PS00111 Phosphoglycerate kinase signature
220341009683	erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535
220341009684	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
220341009685	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
220341009686	PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site
220341009687	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
220341009688	trimer interface [polypeptide binding]; other site
220341009689	putative Zn binding site [ion binding]; other site
220341009690	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
220341009691	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
220341009692	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
220341009693	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
220341009694	Walker A/P-loop; other site
220341009695	ATP binding site [chemical binding]; other site
220341009696	Q-loop/lid; other site
220341009697	ABC transporter signature motif; other site
220341009698	Walker B; other site
220341009699	D-loop; other site
220341009700	H-loop/switch region; other site
220341009701	PS00017 ATP/GTP-binding site motif A (P-loop)
220341009702	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
220341009703	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
220341009704	Walker A/P-loop; other site
220341009705	ATP binding site [chemical binding]; other site
220341009706	Q-loop/lid; other site
220341009707	ABC transporter signature motif; other site
220341009708	Walker B; other site
220341009709	D-loop; other site
220341009710	H-loop/switch region; other site
220341009711	PS00017 ATP/GTP-binding site motif A (P-loop)
220341009712	IS200
220341009713	Transposase IS200 like; Region: Y1_Tnp; pfam01797
220341009714	transketolase; Reviewed; Region: PRK12753
220341009715	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
220341009716	TPP-binding site [chemical binding]; other site
220341009717	dimer interface [polypeptide binding]; other site
220341009718	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
220341009719	PYR/PP interface [polypeptide binding]; other site
220341009720	dimer interface [polypeptide binding]; other site
220341009721	TPP binding site [chemical binding]; other site
220341009722	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
220341009723	PS00802 Transketolase signature 2
220341009724	PS00801 Transketolase signature 1
220341009725	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
220341009726	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
220341009727	oligomer interface [polypeptide binding]; other site
220341009728	putative active site [active]
220341009729	Mn binding site [ion binding]; other site
220341009730	PS01053 Arginase family signature 3
220341009731	PS00148 Arginase family signature 2
220341009732	PS00147 Arginase family signature 1
220341009733	Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166
220341009734	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
220341009735	dimer interface [polypeptide binding]; other site
220341009736	active site
220341009737	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
220341009738	catalytic residues [active]
220341009739	substrate binding site [chemical binding]; other site
220341009740	PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2
220341009741	PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site
220341009742	Virulence promoting factor; Region: YqgB; pfam11036
220341009743	S-adenosylmethionine synthetase; Validated; Region: PRK05250
220341009744	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
220341009745	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
220341009746	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
220341009747	PS00376 S-adenosylmethionine synthetase signature 1
220341009748	PS00377 S-adenosylmethionine synthetase signature 2
220341009749	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
220341009750	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341009751	putative substrate translocation pore; other site
220341009752	PS00217 Sugar transport proteins signature 2
220341009753	PS00216 Sugar transport proteins signature 1
220341009754	hypothetical protein; Provisional; Region: PRK04860
220341009755	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature
220341009756	DNA-specific endonuclease I; Provisional; Region: PRK15137
220341009757	RNA methyltransferase, RsmE family; Region: TIGR00046
220341009758	glutathione synthetase; Provisional; Region: PRK05246
220341009759	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
220341009760	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
220341009761	hypothetical protein; Validated; Region: PRK00228
220341009762	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
220341009763	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
220341009764	Transcriptional regulator [Transcription]; Region: IclR; COG1414
220341009765	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
220341009766	Walker A motif; other site
220341009767	ATP binding site [chemical binding]; other site
220341009768	Walker B motif; other site
220341009769	PS00662 Bacterial type II secretion system protein E signature
220341009770	PS00017 ATP/GTP-binding site motif A (P-loop)
220341009771	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
220341009772	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
220341009773	catalytic residue [active]
220341009774	PS01211 Uncharacterized protein family UPF0001 signature
220341009775	YGGT family; Region: YGGT; pfam02325
220341009776	Predicted integral membrane protein [Function unknown]; Region: COG0762
220341009777	hypothetical protein; Validated; Region: PRK05090
220341009778	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
220341009779	active site
220341009780	dimerization interface [polypeptide binding]; other site
220341009781	HemN family oxidoreductase; Provisional; Region: PRK05660
220341009782	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
220341009783	FeS/SAM binding site; other site
220341009784	HemN C-terminal domain; Region: HemN_C; pfam06969
220341009785	Protein of unknown function (DUF1202); Region: DUF1202; pfam06717
220341009786	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411
220341009787	active site
220341009788	homodimer interface [polypeptide binding]; other site
220341009789	PS00917 Asparaginase / glutaminase active site signature 2
220341009790	PS00144 Asparaginase / glutaminase active site signature 1
220341009791	IS200
220341009792	Transposase IS200 like; Region: Y1_Tnp; pfam01797
220341009793	hypothetical protein; Provisional; Region: PRK10626
220341009794	hypothetical protein; Provisional; Region: PRK11702
220341009795	Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220
220341009796	adenine DNA glycosylase; Provisional; Region: PRK10880
220341009797	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
220341009798	minor groove reading motif; other site
220341009799	helix-hairpin-helix signature motif; other site
220341009800	substrate binding pocket [chemical binding]; other site
220341009801	active site
220341009802	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
220341009803	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
220341009804	DNA binding and oxoG recognition site [nucleotide binding]
220341009805	PS01155 Endonuclease III family signature
220341009806	PS00764 Endonuclease III iron-sulfur binding region signature
220341009807	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2924
220341009808	murein transglycosylase C; Provisional; Region: mltC; PRK11671
220341009809	Domain of unknown function (DUF3393); Region: DUF3393; pfam11873
220341009810	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
220341009811	N-acetyl-D-glucosamine binding site [chemical binding]; other site
220341009812	catalytic residue [active]
220341009813	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341009814	PS00922 Prokaryotic transglycosylases signature
220341009815	nucleoside transporter; Region: 2A0110; TIGR00889
220341009816	Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825
220341009817	PS00703 Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
220341009818	Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811
220341009819	Salmonella Pathogenicity Island 8
220341009820	This CDS contains a stop codon and is similar to the C-termini of several including: Escherichia coli hypothetical 19.3 kDa protein TR:O52671 (EMBL:AF044503) (172 aa) fasta scores: E(): 5e-16, 82.1% id in 39 aa and to Vibrio cholerae hcp=28 kDa secreted hydrophilic protein Hcp TR:P72350 (EMBL:S81006) (172 aa) fasta scores: E(): 3.1e-12, 66.7% id in 39 aa
220341009821	Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320
220341009822	Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320
220341009823	Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092
220341009824	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
220341009825	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
220341009826	DNA binding residues [nucleotide binding]
220341009827	dimerization interface [polypeptide binding]; other site
220341009828	PS00622 Bacterial regulatory proteins, luxR family signature
220341009829	Protein of unknown function (DUF3156); Region: DUF3156; pfam11354
220341009830	Amino acid permease; Region: AA_permease_2; pfam13520
220341009831	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
220341009832	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
220341009833	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
220341009834	Escherichia coli NAD+-dependent phenylacetaldehyde dehydrogenase PadA-like; Region: ALDH_PADH_NahF; cd07113
220341009835	NAD(P) binding site [chemical binding]; other site
220341009836	catalytic residues [active]
220341009837	PS00687 Aldehyde dehydrogenases glutamic acid active site
220341009838	PS00070 Aldehyde dehydrogenases cysteine active site
220341009839	Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion,    and vesicular transport]; Region: Hcp; COG3157
220341009840	Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938
220341009841	active site
220341009842	catalytic site [active]
220341009843	Zn binding site [ion binding]; other site
220341009844	tetramer interface [polypeptide binding]; other site
220341009845	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
220341009846	active site
220341009847	catalytic triad [active]
220341009848	dimer interface [polypeptide binding]; other site
220341009849	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341009850	D-galactonate transporter; Region: 2A0114; TIGR00893
220341009851	putative substrate translocation pore; other site
220341009852	mannonate dehydratase; Provisional; Region: PRK03906
220341009853	mannonate dehydratase; Region: uxuA; TIGR00695
220341009854	D-mannonate oxidoreductase; Provisional; Region: PRK15037
220341009855	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
220341009856	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
220341009857	PS00974 Mannitol dehydrogenases signature
220341009858	PS00017 ATP/GTP-binding site motif A (P-loop)
220341009859	glucuronate isomerase; Reviewed; Region: PRK02925
220341009860	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050
220341009861	dimer interface [polypeptide binding]; other site
220341009862	putative CheW interface [polypeptide binding]; other site
220341009863	Chemoreceptor zinc-binding domain; Region: CZB; pfam13682
220341009864	bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507
220341009865	CHAP domain; Region: CHAP; pfam05257
220341009866	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
220341009867	putative S-transferase; Provisional; Region: PRK11752
220341009868	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
220341009869	C-terminal domain interface [polypeptide binding]; other site
220341009870	GSH binding site (G-site) [chemical binding]; other site
220341009871	dimer interface [polypeptide binding]; other site
220341009872	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
220341009873	dimer interface [polypeptide binding]; other site
220341009874	N-terminal domain interface [polypeptide binding]; other site
220341009875	active site
220341009876	molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537
220341009877	Periplasmic binding protein TroA_e.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142
220341009878	putative ligand binding residues [chemical binding]; other site
220341009879	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
220341009880	hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413
220341009881	hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380
220341009882	PS01249 Hydrogenases expression/synthesis hypA family signature
220341009883	hydrogenase 2-specific chaperone; Provisional; Region: PRK10465
220341009884	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
220341009885	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
220341009886	putative substrate-binding site; other site
220341009887	nickel binding site [ion binding]; other site
220341009888	hydrogenase 2 large subunit; Provisional; Region: PRK10467
220341009889	PS00508 Nickel-dependent hydrogenases large subunit signature 2
220341009890	PS00507 Nickel-dependent hydrogenases large subunit signature 1
220341009891	putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881
220341009892	hydrogenase 2 protein HybA; Provisional; Region: PRK10882
220341009893	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
220341009894	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
220341009895	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341009896	hydrogenase 2 small subunit; Provisional; Region: PRK10468
220341009897	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
220341009898	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
220341009899	NiFe/NiFeSe hydrogenase small subunit C-terminal; Region: NiFe_hyd_SSU_C; pfam14720
220341009900	Protein of unknown function (DUF2623); Region: DUF2623; pfam11115
220341009901	PS00538 Bacterial chemotaxis sensory transducers signature
220341009902	hypothetical protein; Provisional; Region: PRK05208
220341009903	oxidoreductase; Provisional; Region: PRK07985
220341009904	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
220341009905	NAD binding site [chemical binding]; other site
220341009906	metal binding site [ion binding]; metal-binding site
220341009907	active site
220341009908	PS00061 Short-chain dehydrogenases/reductases family signature
220341009909	biopolymer transport protein ExbD; Provisional; Region: PRK11267
220341009910	biopolymer transport protein ExbB; Provisional; Region: PRK10414
220341009911	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
220341009912	homodimer interface [polypeptide binding]; other site
220341009913	substrate-cofactor binding pocket; other site
220341009914	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341009915	catalytic residue [active]
220341009916	PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site
220341009917	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
220341009918	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
220341009919	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
220341009920	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341009921	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341009922	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
220341009923	dimer interface [polypeptide binding]; other site
220341009924	active site
220341009925	metal binding site [ion binding]; metal-binding site
220341009926	PS00913 Iron-containing alcohol dehydrogenases signature 1
220341009927	PS00060 Iron-containing alcohol dehydrogenases signature 2
220341009928	PS00798 Aldo/keto reductase family signature 1
220341009929	PS00062 Aldo/keto reductase family signature 2
220341009930	PS00063 Aldo/keto reductase family putative active site signature
220341009931	Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939
220341009932	anion transporter; Region: dass; TIGR00785
220341009933	transmembrane helices; other site
220341009934	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
220341009935	nucleotide binding site/active site [active]
220341009936	catalytic residue [active]
220341009937	hypothetical protein; Provisional; Region: PRK01254
220341009938	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
220341009939	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
220341009940	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
220341009941	PS01278 Uncharacterized protein family UPF0004 signature
220341009942	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
220341009943	FtsI repressor; Provisional; Region: PRK10883
220341009944	Sulfur oxidation protein SoxY; Region: SoxY; cl19207
220341009945	The first Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_1_CueO_FtsP; cd04232
220341009946	Domain 2 interface [polypeptide binding]; other site
220341009947	Domain 3 interface [polypeptide binding]; other site
220341009948	trinuclear Cu binding site [ion binding]; other site
220341009949	The second Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_2_CueO_FtsP; cd13867
220341009950	Domain 1 interface [polypeptide binding]; other site
220341009951	Domain 3 interface [polypeptide binding]; other site
220341009952	The third Cupredoxin domain of the multicopper oxidase CueO, the cell division protein FtsP, and similar proteins; Region: CuRO_3_CueO_FtsP; cd13890
220341009953	Domain 2 interface [polypeptide binding]; other site
220341009954	Domain 1 interface [polypeptide binding]; other site
220341009955	Type 1 (T1) Cu binding site [ion binding]; other site
220341009956	trinuclear Cu binding site [ion binding]; other site
220341009957	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
220341009958	putative acyl-acceptor binding pocket; other site
220341009959	DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062
220341009960	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
220341009961	CAP-like domain; other site
220341009962	active site
220341009963	primary dimer interface [polypeptide binding]; other site
220341009964	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
220341009965	PS00017 ATP/GTP-binding site motif A (P-loop)
220341009966	Helix-turn-helix domain; Region: HTH_18; pfam12833
220341009967	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341009968	DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449
220341009969	PS00041 Bacterial regulatory proteins, araC family signature
220341009970	Periplasmic protein with OB-fold [Function unknown]; Region: COG3111
220341009971	DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336
220341009972	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
220341009973	active site
220341009974	phosphorylation site [posttranslational modification]
220341009975	intermolecular recognition site; other site
220341009976	dimerization interface [polypeptide binding]; other site
220341009977	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
220341009978	DNA binding site [nucleotide binding]
220341009979	sensor protein QseC; Provisional; Region: PRK10337
220341009980	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
220341009981	dimer interface [polypeptide binding]; other site
220341009982	phosphorylation site [posttranslational modification]
220341009983	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
220341009984	ATP binding site [chemical binding]; other site
220341009985	Mg2+ binding site [ion binding]; other site
220341009986	G-X-G motif; other site
220341009987	Uncharacterized conserved protein [Function unknown]; Region: COG1359
220341009988	DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055
220341009989	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
220341009990	ATP binding site [chemical binding]; other site
220341009991	Mg2+ binding site [ion binding]; other site
220341009992	G-X-G motif; other site
220341009993	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
220341009994	anchoring element; other site
220341009995	dimer interface [polypeptide binding]; other site
220341009996	ATP binding site [chemical binding]; other site
220341009997	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
220341009998	active site
220341009999	metal binding site [ion binding]; metal-binding site
220341010000	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
220341010001	PS00177 DNA topoisomerase II signature
220341010002	esterase YqiA; Provisional; Region: PRK11071
220341010003	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
220341010004	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
220341010005	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
220341010006	active site
220341010007	metal binding site [ion binding]; metal-binding site
220341010008	hexamer interface [polypeptide binding]; other site
220341010009	putative dehydrogenase; Provisional; Region: PRK11039
220341010010	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
220341010011	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
220341010012	dimer interface [polypeptide binding]; other site
220341010013	ADP-ribose binding site [chemical binding]; other site
220341010014	active site
220341010015	nudix motif; other site
220341010016	metal binding site [ion binding]; metal-binding site
220341010017	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
220341010018	Outer membrane efflux protein; Region: OEP; pfam02321
220341010019	Outer membrane efflux protein; Region: OEP; pfam02321
220341010020	hypothetical protein; Provisional; Region: PRK11653
220341010021	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341010022	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
220341010023	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
220341010024	putative active site [active]
220341010025	metal binding site [ion binding]; metal-binding site
220341010026	zinc transporter ZupT; Provisional; Region: PRK04201
220341010027	Protein of unknown function (DUF4051); Region: DUF4051; pfam13260
220341010028	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
220341010029	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
220341010030	catalytic residues [active]
220341010031	hinge region; other site
220341010032	alpha helical domain; other site
220341010033	putative disulfide oxidoreductase; Provisional; Region: PRK04307
220341010034	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
220341010035	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960
220341010036	glycogen synthesis protein GlgS; Provisional; Region: PRK02922
220341010037	Protein of unknown function (DUF1449); Region: DUF1449; pfam07290
220341010038	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
220341010039	Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_flotillin; cd03399
220341010040	core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107
220341010041	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
220341010042	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
220341010043	putative ribose interaction site [chemical binding]; other site
220341010044	putative ADP binding site [chemical binding]; other site
220341010045	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
220341010046	active site
220341010047	nucleotide binding site [chemical binding]; other site
220341010048	HIGH motif; other site
220341010049	KMSKS motif; other site
220341010050	PS00583 pfkB family of carbohydrate kinases signature 1
220341010051	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
220341010052	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
220341010053	metal binding triad; other site
220341010054	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
220341010055	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
220341010056	metal binding triad; other site
220341010057	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; cl19627
220341010058	PS00904 Protein prenyltransferases alpha subunit repeat signature
220341010059	Uncharacterized conserved protein [Function unknown]; Region: COG3025
220341010060	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
220341010061	putative active site [active]
220341010062	putative metal binding residues [ion binding]; other site
220341010063	signature motif; other site
220341010064	putative triphosphate binding site [ion binding]; other site
220341010065	CHAD domain; Region: CHAD; pfam05235
220341010066	SH3 domain-containing protein; Provisional; Region: PRK10884
220341010067	Bacterial SH3 domain homologues; Region: SH3b; smart00287
220341010068	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
220341010069	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
220341010070	active site
220341010071	NTP binding site [chemical binding]; other site
220341010072	metal binding triad [ion binding]; metal-binding site
220341010073	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
220341010074	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
220341010075	Zn2+ binding site [ion binding]; other site
220341010076	Mg2+ binding site [ion binding]; other site
220341010077	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
220341010078	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
220341010079	homooctamer interface [polypeptide binding]; other site
220341010080	active site
220341010081	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
220341010082	UGMP family protein; Validated; Region: PRK09604
220341010083	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
220341010084	nucleotide binding site [chemical binding]; other site
220341010085	PS01016 Glycoprotease family signature
220341010086	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
220341010087	PS01181 Ribosomal protein S21 signature
220341010088	DNA primase; Validated; Region: dnaG; PRK05667
220341010089	CHC2 zinc finger; Region: zf-CHC2; pfam01807
220341010090	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
220341010091	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
220341010092	active site
220341010093	metal binding site [ion binding]; metal-binding site
220341010094	interdomain interaction site; other site
220341010095	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
220341010096	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
220341010097	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
220341010098	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
220341010099	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
220341010100	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
220341010101	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
220341010102	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
220341010103	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
220341010104	DNA binding residues [nucleotide binding]
220341010105	PS00715 Sigma-70 factors family signature 1
220341010106	PS00716 Sigma-70 factors family signature 2
220341010107	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
220341010108	active site
220341010109	SUMO-1 interface [polypeptide binding]; other site
220341010110	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
220341010111	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
220341010112	FAD binding pocket [chemical binding]; other site
220341010113	FAD binding motif [chemical binding]; other site
220341010114	phosphate binding motif [ion binding]; other site
220341010115	NAD binding pocket [chemical binding]; other site
220341010116	Predicted transcriptional regulators [Transcription]; Region: COG1695
220341010117	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
220341010118	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
220341010119	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
220341010120	dimerization interface [polypeptide binding]; other site
220341010121	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050
220341010122	dimer interface [polypeptide binding]; other site
220341010123	putative CheW interface [polypeptide binding]; other site
220341010124	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
220341010125	PAS fold; Region: PAS_3; pfam08447
220341010126	putative active site [active]
220341010127	heme pocket [chemical binding]; other site
220341010128	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
220341010129	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
220341010130	dimer interface [polypeptide binding]; other site
220341010131	putative CheW interface [polypeptide binding]; other site
220341010132	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
220341010133	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
220341010134	inhibitor-cofactor binding pocket; inhibition site
220341010135	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341010136	catalytic residue [active]
220341010137	PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site
220341010138	SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001
220341010139	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
220341010140	S-adenosylmethionine binding site [chemical binding]; other site
220341010141	PS00092 N-6 Adenine-specific DNA methylases signature
220341010142	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
220341010143	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
220341010144	putative active site [active]
220341010145	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
220341010146	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
220341010147	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
220341010148	serine/threonine transporter SstT; Provisional; Region: PRK13628
220341010149	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
220341010150	EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629
220341010151	Protein of unknown function (DUF1090); Region: DUF1090; pfam06476
220341010152	Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575
220341010153	Predicted membrane protein [Function unknown]; Region: COG5393
220341010154	YqjK-like protein; Region: YqjK; pfam13997
220341010155	Predicted membrane protein [Function unknown]; Region: COG2259
220341010156	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
220341010157	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
220341010158	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
220341010159	putative dimer interface [polypeptide binding]; other site
220341010160	N-terminal domain interface [polypeptide binding]; other site
220341010161	putative substrate binding pocket (H-site) [chemical binding]; other site
220341010162	Predicted membrane protein [Function unknown]; Region: COG3152
220341010163	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341010164	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
220341010165	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
220341010166	dimerization interface [polypeptide binding]; other site
220341010167	PS00044 Bacterial regulatory proteins, lysR family signature
220341010168	Pirin-related protein [General function prediction only]; Region: COG1741
220341010169	Pirin; Region: Pirin; pfam02678
220341010170	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
220341010171	L-serine dehydratase TdcG; Provisional; Region: PRK15040
220341010172	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
220341010173	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
220341010174	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
220341010175	Pyruvate formate lyase 1; Region: PFL1; cd01678
220341010176	coenzyme A binding site [chemical binding]; other site
220341010177	active site
220341010178	catalytic residues [active]
220341010179	glycine loop; other site
220341010180	PS00850 Glycine radical signature
220341010181	propionate/acetate kinase; Provisional; Region: PRK12379
220341010182	PS01076 Acetate and butyrate kinases family signature 2
220341010183	PS01075 Acetate and butyrate kinases family signature 1
220341010184	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
220341010185	tetramer interface [polypeptide binding]; other site
220341010186	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341010187	catalytic residue [active]
220341010188	PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site
220341010189	DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341
220341010190	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341010191	The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418
220341010192	putative substrate binding pocket [chemical binding]; other site
220341010193	putative dimerization interface [polypeptide binding]; other site
220341010194	PS00044 Bacterial regulatory proteins, lysR family signature
220341010195	glycerate kinase I; Provisional; Region: PRK10342
220341010196	tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559
220341010197	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
220341010198	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833
220341010199	PS00895 3-hydroxyisobutyrate dehydrogenase signature
220341010200	alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558
220341010201	galactarate dehydratase; Region: galactar-dH20; TIGR03248
220341010202	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
220341010203	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
220341010204	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
220341010205	substrate binding site [chemical binding]; other site
220341010206	ATP binding site [chemical binding]; other site
220341010207	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
220341010208	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
220341010209	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
220341010210	PS00894 Bacterial regulatory proteins, deoR family signature
220341010211	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
220341010212	intersubunit interface [polypeptide binding]; other site
220341010213	active site
220341010214	zinc binding site [ion binding]; other site
220341010215	Na+ binding site [ion binding]; other site
220341010216	PS00602 Fructose-bisphosphate aldolase class-II signature 1
220341010217	PS00806 Fructose-bisphosphate aldolase class-II signature 2
220341010218	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
220341010219	putative substrate binding site [chemical binding]; other site
220341010220	putative ATP binding site [chemical binding]; other site
220341010221	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
220341010222	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
220341010223	active site
220341010224	P-loop; other site
220341010225	phosphorylation site [posttranslational modification]
220341010226	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
220341010227	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109
220341010228	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
220341010229	active site
220341010230	phosphorylation site [posttranslational modification]
220341010231	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
220341010232	dimerization domain swap beta strand [polypeptide binding]; other site
220341010233	regulatory protein interface [polypeptide binding]; other site
220341010234	active site
220341010235	regulatory phosphorylation site [posttranslational modification]; other site
220341010236	PS00372 PTS EIIA domains phosphorylation site signature 2
220341010237	PS00369 PTS HPR component histidine phosphorylation site signature
220341010238	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
220341010239	active site
220341010240	phosphorylation site [posttranslational modification]
220341010241	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
220341010242	active site
220341010243	P-loop; other site
220341010244	phosphorylation site [posttranslational modification]
220341010245	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
220341010246	galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309
220341010247	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
220341010248	putative NAD(P) binding site [chemical binding]; other site
220341010249	catalytic Zn binding site [ion binding]; other site
220341010250	PS00059 Zinc-containing alcohol dehydrogenases signature
220341010251	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
220341010252	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
220341010253	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
220341010254	PS00894 Bacterial regulatory proteins, deoR family signature
220341010255	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
220341010256	putative SAM binding site [chemical binding]; other site
220341010257	putative homodimer interface [polypeptide binding]; other site
220341010258	Putative lipoprotein [General function prediction only]; Region: LppC; COG3107
220341010259	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
220341010260	putative ligand binding site [chemical binding]; other site
220341010261	PS00017 ATP/GTP-binding site motif A (P-loop)
220341010262	TIGR00252 family protein; Region: TIGR00252
220341010263	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
220341010264	dimer interface [polypeptide binding]; other site
220341010265	active site
220341010266	outer membrane lipoprotein; Provisional; Region: PRK11023
220341010267	BON domain; Region: BON; pfam04972
220341010268	BON domain; Region: BON; pfam04972
220341010269	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341010270	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
220341010271	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
220341010272	NAD(P) binding site [chemical binding]; other site
220341010273	active site
220341010274	intracellular protease, PfpI family; Region: PfpI; TIGR01382
220341010275	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
220341010276	proposed catalytic triad [active]
220341010277	conserved cys residue [active]
220341010278	hypothetical protein; Provisional; Region: PRK03467
220341010279	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
220341010280	GIY-YIG motif/motif A; other site
220341010281	putative active site [active]
220341010282	putative metal binding site [ion binding]; other site
220341010283	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
220341010284	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
220341010285	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
220341010286	Coenzyme A binding pocket [chemical binding]; other site
220341010287	Putative lipid carrier protein [Lipid metabolism]; Region: COG3154
220341010288	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
220341010289	PS01276 Peptidase family U32 signature
220341010290	putative protease; Provisional; Region: PRK15447
220341010291	hypothetical protein; Provisional; Region: PRK10508
220341010292	tryptophan permease; Provisional; Region: PRK10483
220341010293	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
220341010294	PS00594 Aromatic amino acids permeases signature
220341010295	ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634
220341010296	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
220341010297	ATP binding site [chemical binding]; other site
220341010298	Mg++ binding site [ion binding]; other site
220341010299	motif III; other site
220341010300	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
220341010301	nucleotide binding region [chemical binding]; other site
220341010302	ATP-binding site [chemical binding]; other site
220341010303	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
220341010304	putative RNA binding site [nucleotide binding]; other site
220341010305	Cold shock protein DEAD box A; Region: DEADboxA; pfam12343
220341010306	PS00039 DEAD-box subfamily ATP-dependent helicases signature
220341010307	PS00017 ATP/GTP-binding site motif A (P-loop)
220341010308	lipoprotein NlpI; Provisional; Region: PRK11189
220341010309	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
220341010310	binding surface
220341010311	TPR motif; other site
220341010312	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
220341010313	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
220341010314	RNase E interface [polypeptide binding]; other site
220341010315	trimer interface [polypeptide binding]; other site
220341010316	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
220341010317	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
220341010318	RNase E interface [polypeptide binding]; other site
220341010319	trimer interface [polypeptide binding]; other site
220341010320	active site
220341010321	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
220341010322	putative nucleic acid binding region [nucleotide binding]; other site
220341010323	G-X-X-G motif; other site
220341010324	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
220341010325	RNA binding site [nucleotide binding]; other site
220341010326	domain interface; other site
220341010327	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
220341010328	16S/18S rRNA binding site [nucleotide binding]; other site
220341010329	S13e-L30e interaction site [polypeptide binding]; other site
220341010330	25S rRNA binding site [nucleotide binding]; other site
220341010331	PS00362 Ribosomal protein S15 signature
220341010332	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
220341010333	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
220341010334	RNA binding site [nucleotide binding]; other site
220341010335	active site
220341010336	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
220341010337	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
220341010338	PS01319 Ribosome-binding factor A signature
220341010339	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
220341010340	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
220341010341	translation initiation factor IF-2; Validated; Region: infB; PRK05306
220341010342	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
220341010343	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
220341010344	G1 box; other site
220341010345	putative GEF interaction site [polypeptide binding]; other site
220341010346	GTP/Mg2+ binding site [chemical binding]; other site
220341010347	Switch I region; other site
220341010348	G2 box; other site
220341010349	G3 box; other site
220341010350	Switch II region; other site
220341010351	G4 box; other site
220341010352	G5 box; other site
220341010353	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
220341010354	Translation-initiation factor 2; Region: IF-2; pfam11987
220341010355	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
220341010356	PS01176 Initiation factor 2 signature
220341010357	PS00017 ATP/GTP-binding site motif A (P-loop)
220341010358	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
220341010359	NusA N-terminal domain; Region: NusA_N; pfam08529
220341010360	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
220341010361	RNA binding site [nucleotide binding]; other site
220341010362	homodimer interface [polypeptide binding]; other site
220341010363	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
220341010364	G-X-X-G motif; other site
220341010365	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
220341010366	G-X-X-G motif; other site
220341010367	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
220341010368	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
220341010369	hypothetical protein; Provisional; Region: PRK14641
220341010370	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
220341010371	putative oligomer interface [polypeptide binding]; other site
220341010372	putative RNA binding site [nucleotide binding]; other site
220341010373	argininosuccinate synthase; Validated; Region: PRK05370
220341010374	PS00564 Argininosuccinate synthase signature 1
220341010375	PS00565 Argininosuccinate synthase signature 2
220341010376	Preprotein translocase SecG subunit; Region: SecG; pfam03840
220341010377	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
220341010378	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
220341010379	active site
220341010380	substrate binding site [chemical binding]; other site
220341010381	metal binding site [ion binding]; metal-binding site
220341010382	PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature
220341010383	Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294
220341010384	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
220341010385	substrate binding pocket [chemical binding]; other site
220341010386	dimer interface [polypeptide binding]; other site
220341010387	inhibitor binding site; inhibition site
220341010388	PS00793 Dihydropteroate synthase signature 2
220341010389	PS00792 Dihydropteroate synthase signature 1
220341010390	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
220341010391	FtsH Extracellular; Region: FtsH_ext; pfam06480
220341010392	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
220341010393	Walker A motif; other site
220341010394	ATP binding site [chemical binding]; other site
220341010395	Walker B motif; other site
220341010396	arginine finger; other site
220341010397	Peptidase family M41; Region: Peptidase_M41; pfam01434
220341010398	PS00674 AAA-protein family signature
220341010399	PS00017 ATP/GTP-binding site motif A (P-loop)
220341010400	PS00017 ATP/GTP-binding site motif A (P-loop)
220341010401	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
220341010402	S-adenosylmethionine binding site [chemical binding]; other site
220341010403	RNA-binding protein YhbY; Provisional; Region: PRK10343
220341010404	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
220341010405	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
220341010406	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
220341010407	PS00830 Prokaryotic transcription elongation factors signature 2
220341010408	PS00829 Prokaryotic transcription elongation factors signature 1
220341010409	D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113
220341010410	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
220341010411	GTPase CgtA; Reviewed; Region: obgE; PRK12298
220341010412	GTP1/OBG; Region: GTP1_OBG; pfam01018
220341010413	Obg GTPase; Region: Obg; cd01898
220341010414	G1 box; other site
220341010415	GTP/Mg2+ binding site [chemical binding]; other site
220341010416	Switch I region; other site
220341010417	G2 box; other site
220341010418	G3 box; other site
220341010419	Switch II region; other site
220341010420	G4 box; other site
220341010421	G5 box; other site
220341010422	PS00905 GTP1/OBG family signature
220341010423	PS00017 ATP/GTP-binding site motif A (P-loop)
220341010424	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
220341010425	EamA-like transporter family; Region: EamA; pfam00892
220341010426	EamA-like transporter family; Region: EamA; pfam00892
220341010427	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
220341010428	PS00831 Ribosomal protein L27 signature
220341010429	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
220341010430	PS01169 Ribosomal protein L21 signature
220341010431	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
220341010432	substrate binding pocket [chemical binding]; other site
220341010433	chain length determination region; other site
220341010434	substrate-Mg2+ binding site; other site
220341010435	catalytic residues [active]
220341010436	aspartate-rich region 1; other site
220341010437	active site lid residues [active]
220341010438	aspartate-rich region 2; other site
220341010439	PS00723 Polyprenyl synthetases signature 1
220341010440	PS00444 Polyprenyl synthetases signature 2
220341010441	DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344
220341010442	EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275
220341010443	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
220341010444	hinge; other site
220341010445	active site
220341010446	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
220341010447	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
220341010448	anti sigma factor interaction site; other site
220341010449	regulatory phosphorylation site [posttranslational modification]; other site
220341010450	ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117
220341010451	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
220341010452	mce related protein; Region: MCE; pfam02470
220341010453	conserved hypothetical integral membrane protein; Region: TIGR00056
220341010454	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
220341010455	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
220341010456	Walker A/P-loop; other site
220341010457	ATP binding site [chemical binding]; other site
220341010458	Q-loop/lid; other site
220341010459	ABC transporter signature motif; other site
220341010460	Walker B; other site
220341010461	D-loop; other site
220341010462	H-loop/switch region; other site
220341010463	PS00211 ABC transporters family signature
220341010464	PS00017 ATP/GTP-binding site motif A (P-loop)
220341010465	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
220341010466	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
220341010467	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
220341010468	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
220341010469	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
220341010470	putative active site [active]
220341010471	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
220341010472	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484
220341010473	lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893
220341010474	lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894
220341010475	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934
220341010476	lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895
220341010477	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
220341010478	Walker A/P-loop; other site
220341010479	ATP binding site [chemical binding]; other site
220341010480	Q-loop/lid; other site
220341010481	ABC transporter signature motif; other site
220341010482	Walker B; other site
220341010483	D-loop; other site
220341010484	H-loop/switch region; other site
220341010485	PS00017 ATP/GTP-binding site motif A (P-loop)
220341010486	PS00211 ABC transporters family signature
220341010487	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
220341010488	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
220341010489	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
220341010490	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
220341010491	PS00717 Sigma-54 factors family signature 1
220341010492	PS00718 Sigma-54 factors family signature 2
220341010493	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
220341010494	30S subunit binding site; other site
220341010495	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
220341010496	active site
220341010497	phosphorylation site [posttranslational modification]
220341010498	PS00372 PTS EIIA domains phosphorylation site signature 2
220341010499	P-loop ATPase protein family; Region: ATP_bind_2; pfam03668
220341010500	PS00017 ATP/GTP-binding site motif A (P-loop)
220341010501	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
220341010502	dimerization domain swap beta strand [polypeptide binding]; other site
220341010503	regulatory protein interface [polypeptide binding]; other site
220341010504	active site
220341010505	regulatory phosphorylation site [posttranslational modification]; other site
220341010506	PS00369 PTS HPR component histidine phosphorylation site signature
220341010507	PS00589 PTS HPR component serine phosphorylation site signature
220341010508	region of low G+C (27%) and multiple short homopolymeric base sequences
220341010509	hypothetical protein; Provisional; Region: PRK10345
220341010510	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
220341010511	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
220341010512	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
220341010513	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
220341010514	conserved cys residue [active]
220341010515	aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091
220341010516	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
220341010517	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
220341010518	putative active site [active]
220341010519	heme pocket [chemical binding]; other site
220341010520	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
220341010521	dimer interface [polypeptide binding]; other site
220341010522	phosphorylation site [posttranslational modification]
220341010523	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
220341010524	ATP binding site [chemical binding]; other site
220341010525	Mg2+ binding site [ion binding]; other site
220341010526	G-X-G motif; other site
220341010527	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
220341010528	active site
220341010529	phosphorylation site [posttranslational modification]
220341010530	intermolecular recognition site; other site
220341010531	dimerization interface [polypeptide binding]; other site
220341010532	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
220341010533	putative binding surface; other site
220341010534	active site
220341010535	radical SAM protein, TIGR01212 family; Region: TIGR01212
220341010536	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
220341010537	FeS/SAM binding site; other site
220341010538	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
220341010539	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
220341010540	active site
220341010541	dimer interface [polypeptide binding]; other site
220341010542	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
220341010543	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
220341010544	active site
220341010545	FMN binding site [chemical binding]; other site
220341010546	substrate binding site [chemical binding]; other site
220341010547	3Fe-4S cluster binding site [ion binding]; other site
220341010548	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
220341010549	domain interface; other site
220341010550	PS00017 ATP/GTP-binding site motif A (P-loop)
220341010551	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
220341010552	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691
220341010553	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
220341010554	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
220341010555	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
220341010556	nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484
220341010557	Na binding site [ion binding]; other site
220341010558	putative substrate binding site [chemical binding]; other site
220341010559	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
220341010560	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
220341010561	active site
220341010562	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
220341010563	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
220341010564	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
220341010565	nucleotide binding site [chemical binding]; other site
220341010566	PS01125 ROK family signature
220341010567	putative sialic acid transporter; Provisional; Region: PRK03893
220341010568	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341010569	putative substrate translocation pore; other site
220341010570	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
220341010571	inhibitor site; inhibition site
220341010572	active site
220341010573	dimer interface [polypeptide binding]; other site
220341010574	catalytic residue [active]
220341010575	PS00666 Dihydrodipicolinate synthetase signature 2
220341010576	PS00665 Dihydrodipicolinate synthetase signature 1
220341010577	transcriptional regulator NanR; Provisional; Region: PRK03837
220341010578	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
220341010579	DNA-binding site [nucleotide binding]; DNA binding site
220341010580	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
220341010581	PS00043 Bacterial regulatory proteins, gntR family signature
220341010582	Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969
220341010583	stringent starvation protein A; Provisional; Region: sspA; PRK09481
220341010584	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
220341010585	C-terminal domain interface [polypeptide binding]; other site
220341010586	putative GSH binding site (G-site) [chemical binding]; other site
220341010587	dimer interface [polypeptide binding]; other site
220341010588	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
220341010589	dimer interface [polypeptide binding]; other site
220341010590	N-terminal domain interface [polypeptide binding]; other site
220341010591	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
220341010592	PS00360 Ribosomal protein S9 signature
220341010593	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
220341010594	23S rRNA interface [nucleotide binding]; other site
220341010595	L3 interface [polypeptide binding]; other site
220341010596	PS00783 Ribosomal protein L13 signature
220341010597	Predicted ATPase [General function prediction only]; Region: COG1485
220341010598	PS00017 ATP/GTP-binding site motif A (P-loop)
220341010599	hypothetical protein; Provisional; Region: PRK11677
220341010600	serine endoprotease; Provisional; Region: PRK10139
220341010601	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
220341010602	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
220341010603	protein binding site [polypeptide binding]; other site
220341010604	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
220341010605	PS00017 ATP/GTP-binding site motif A (P-loop)
220341010606	serine endoprotease; Provisional; Region: PRK10898
220341010607	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
220341010608	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
220341010609	protein binding site [polypeptide binding]; other site
220341010610	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768
220341010611	oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15477
220341010612	oxaloacetate decarboxylase; Provisional; Region: PRK14040
220341010613	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
220341010614	active site
220341010615	catalytic residues [active]
220341010616	metal binding site [ion binding]; metal-binding site
220341010617	homodimer binding site [polypeptide binding]; other site
220341010618	Conserved carboxylase domain; Region: PYC_OADA; pfam02436
220341010619	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
220341010620	carboxyltransferase (CT) interaction site; other site
220341010621	biotinylation site [posttranslational modification]; other site
220341010622	PS00188 Biotin-requiring enzymes attachment site
220341010623	oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919
220341010624	L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228
220341010625	tartrate dehydratase subunit alpha; Validated; Region: PRK08230
220341010626	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
220341010627	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
220341010628	transmembrane helices; other site
220341010629	Transcriptional regulators [Transcription]; Region: FadR; COG2186
220341010630	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
220341010631	DNA-binding site [nucleotide binding]; DNA binding site
220341010632	FCD domain; Region: FCD; pfam07729
220341010633	Transcriptional regulators [Transcription]; Region: GntR; COG1802
220341010634	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
220341010635	DNA-binding site [nucleotide binding]; DNA binding site
220341010636	malate dehydrogenase; Provisional; Region: PRK05086
220341010637	Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337
220341010638	NAD binding site [chemical binding]; other site
220341010639	dimerization interface [polypeptide binding]; other site
220341010640	Substrate binding site [chemical binding]; other site
220341010641	PS00068 Malate dehydrogenase active site signature
220341010642	arginine repressor; Provisional; Region: PRK05066
220341010643	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
220341010644	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
220341010645	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
220341010646	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
220341010647	Barstar, RNAse (barnase) inhibitor [Transcription]; Region: COG2732
220341010648	RNAase interaction site [polypeptide binding]; other site
220341010649	Predicted membrane protein [Function unknown]; Region: COG1289
220341010650	p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631
220341010651	p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559
220341010652	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
220341010653	HlyD family secretion protein; Region: HlyD_3; pfam13437
220341010654	efflux system membrane protein; Provisional; Region: PRK11594
220341010655	transcriptional regulator; Provisional; Region: PRK10632
220341010656	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341010657	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
220341010658	putative effector binding pocket; other site
220341010659	dimerization interface [polypeptide binding]; other site
220341010660	PS00044 Bacterial regulatory proteins, lysR family signature
220341010661	protease TldD; Provisional; Region: tldD; PRK10735
220341010662	hypothetical protein; Provisional; Region: PRK10899
220341010663	Protein of unknown function; Region: DUF3971; pfam13116
220341010664	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
220341010665	ribonuclease G; Provisional; Region: PRK11712
220341010666	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
220341010667	homodimer interface [polypeptide binding]; other site
220341010668	oligonucleotide binding site [chemical binding]; other site
220341010669	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
220341010670	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
220341010671	active site
220341010672	dimer interface [polypeptide binding]; other site
220341010673	rod shape-determining protein MreD; Provisional; Region: PRK11060
220341010674	rod shape-determining protein MreC; Region: mreC; TIGR00219
220341010675	rod shape-determining protein MreB; Provisional; Region: PRK13927
220341010676	MreB and similar proteins; Region: MreB_like; cd10225
220341010677	nucleotide binding site [chemical binding]; other site
220341010678	Mg binding site [ion binding]; other site
220341010679	putative protofilament interaction site [polypeptide binding]; other site
220341010680	RodZ interaction site [polypeptide binding]; other site
220341010681	regulatory protein CsrD; Provisional; Region: PRK11059
220341010682	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
220341010683	metal binding site [ion binding]; metal-binding site
220341010684	nucleotidyl binding site; other site
220341010685	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
220341010686	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341010687	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
220341010688	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
220341010689	NADP binding site [chemical binding]; other site
220341010690	dimer interface [polypeptide binding]; other site
220341010691	PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature
220341010692	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
220341010693	YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107
220341010694	Moco binding site; other site
220341010695	metal coordination site [ion binding]; other site
220341010696	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
220341010697	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
220341010698	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
220341010699	carboxyltransferase (CT) interaction site; other site
220341010700	biotinylation site [posttranslational modification]; other site
220341010701	PS00188 Biotin-requiring enzymes attachment site
220341010702	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
220341010703	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
220341010704	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
220341010705	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
220341010706	PS00866 Carbamoyl-phosphate synthase subdomain signature 1
220341010707	PS00867 Carbamoyl-phosphate synthase subdomain signature 2
220341010708	hypothetical protein; Provisional; Region: PRK10633
220341010709	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
220341010710	Na binding site [ion binding]; other site
220341010711	PS00456 Sodium:solute symporter family signature 1
220341010712	PS00457 Sodium:solute symporter family signature 2
220341010713	ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406
220341010714	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
220341010715	S-adenosylmethionine binding site [chemical binding]; other site
220341010716	Dihydrouridine synthase (Dus); Region: Dus; pfam01207
220341010717	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
220341010718	FMN binding site [chemical binding]; other site
220341010719	active site
220341010720	catalytic residues [active]
220341010721	substrate binding site [chemical binding]; other site
220341010722	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
220341010723	putative methyltransferase; Provisional; Region: PRK11524
220341010724	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
220341010725	PS00092 N-6 Adenine-specific DNA methylases signature
220341010726	Protein of unknown function (DUF2556); Region: DUF2556; pfam10831
220341010727	This CDS appears to be a gene remnant which is highly similar to the very C-terminus of Escherichia coli acriflavin resistance protein E precursor acrE or envC SW:ACRE_ECOLI (P24180) (385 aa) fasta scores: E(): 0, 88.8% id in 134 aa
220341010728	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341010729	protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104
220341010730	PS00201 Flavodoxin signature
220341010731	potassium transporter; Provisional; Region: PRK10750
220341010732	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
220341010733	hypothetical protein; Provisional; Region: PRK11568
220341010734	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
220341010735	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
220341010736	PS00910 Uncharacterized protein family UPF0029 signature
220341010737	proline dipeptidase; Provisional; Region: PRK13607
220341010738	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
220341010739	active site
220341010740	PS00491 Aminopeptidase P and proline dipeptidase signature
220341010741	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
220341010742	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
220341010743	substrate binding site [chemical binding]; other site
220341010744	oxyanion hole (OAH) forming residues; other site
220341010745	trimer interface [polypeptide binding]; other site
220341010746	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
220341010747	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
220341010748	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
220341010749	PS00166 Enoyl-CoA hydratase/isomerase signature
220341010750	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341010751	PS00067 3-hydroxyacyl-CoA dehydrogenase signature
220341010752	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
220341010753	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
220341010754	dimer interface [polypeptide binding]; other site
220341010755	active site
220341010756	PS00098 Thiolases acyl-enzyme intermediate signature
220341010757	PS00737 Thiolases signature 2
220341010758	PS00099 Thiolases active site
220341010759	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
220341010760	FMN reductase; Validated; Region: fre; PRK08051
220341010761	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
220341010762	FAD binding pocket [chemical binding]; other site
220341010763	FAD binding motif [chemical binding]; other site
220341010764	phosphate binding motif [ion binding]; other site
220341010765	beta-alpha-beta structure motif; other site
220341010766	NAD binding pocket [chemical binding]; other site
220341010767	3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922
220341010768	transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014
220341010769	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
220341010770	KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354
220341010771	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
220341010772	active site
220341010773	PS01091 Uncharacterized protein family UPF0006 signature 3
220341010774	PS01090 Uncharacterized protein family UPF0006 signature 2
220341010775	twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921
220341010776	PS01218 Uncharacterized protein family UPF0032 signature
220341010777	sec-independent translocase; Provisional; Region: PRK01770
220341010778	sec-independent translocase; Provisional; Region: tatB; PRK00404
220341010779	twin arginine translocase protein A; Provisional; Region: tatA; PRK03554
220341010780	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
220341010781	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
220341010782	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
220341010783	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
220341010784	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
220341010785	S-adenosylmethionine binding site [chemical binding]; other site
220341010786	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
220341010787	PS01183 ubiE/COQ5 methyltransferase family signature 1
220341010788	DNA recombination protein RmuC; Provisional; Region: PRK10361
220341010789	RmuC family; Region: RmuC; pfam02646
220341010790	uridine phosphorylase; Provisional; Region: PRK11178
220341010791	PS01232 Purine and other phosphorylases family 1 signature
220341010792	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
220341010793	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
220341010794	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
220341010795	FeS/SAM binding site; other site
220341010796	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
220341010797	SEC-C motif; Region: SEC-C; pfam02810
220341010798	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
220341010799	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
220341010800	THF binding site; other site
220341010801	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
220341010802	substrate binding site [chemical binding]; other site
220341010803	THF binding site; other site
220341010804	zinc-binding site [ion binding]; other site
220341010805	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
220341010806	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341010807	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
220341010808	putative dimerization interface [polypeptide binding]; other site
220341010809	PS00044 Bacterial regulatory proteins, lysR family signature
220341010810	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
220341010811	EamA-like transporter family; Region: EamA; pfam00892
220341010812	putative hydrolase; Provisional; Region: PRK10976
220341010813	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
220341010814	active site
220341010815	motif I; other site
220341010816	motif II; other site
220341010817	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
220341010818	lysophospholipase L2; Provisional; Region: PRK10749
220341010819	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
220341010820	homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520
220341010821	threonine efflux system; Provisional; Region: PRK10229
220341010822	ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057
220341010823	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
220341010824	ATP binding site [chemical binding]; other site
220341010825	putative Mg++ binding site [ion binding]; other site
220341010826	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
220341010827	nucleotide binding region [chemical binding]; other site
220341010828	ATP-binding site [chemical binding]; other site
220341010829	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
220341010830	HRDC domain; Region: HRDC; pfam00570
220341010831	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
220341010832	dimerization interface [polypeptide binding]; other site
220341010833	substrate binding site [chemical binding]; other site
220341010834	active site
220341010835	calcium binding site [ion binding]; other site
220341010836	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
220341010837	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
220341010838	CoenzymeA binding site [chemical binding]; other site
220341010839	subunit interaction site [polypeptide binding]; other site
220341010840	PHB binding site; other site
220341010841	putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430
220341010842	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
220341010843	hypothetical protein; Provisional; Region: PRK11371
220341010844	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
220341010845	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
220341010846	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
220341010847	Cl binding site [ion binding]; other site
220341010848	oligomer interface [polypeptide binding]; other site
220341010849	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
220341010850	Part of AAA domain; Region: AAA_19; pfam13245
220341010851	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
220341010852	PS00017 ATP/GTP-binding site motif A (P-loop)
220341010853	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
220341010854	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
220341010855	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
220341010856	motif II; other site
220341010857	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
220341010858	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
220341010859	active site
220341010860	Int/Topo IB signature motif; other site
220341010861	hypothetical protein; Provisional; Region: PRK10963
220341010862	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
220341010863	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
220341010864	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
220341010865	PS01326 Diaminopimelate epimerase signature
220341010866	Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567
220341010867	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341010868	PS00017 ATP/GTP-binding site motif A (P-loop)
220341010869	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
220341010870	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503
220341010871	putative iron binding site [ion binding]; other site
220341010872	Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072
220341010873	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
220341010874	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
220341010875	PS01093 Adenylate cyclases class-I signature 2
220341010876	PS01092 Adenylate cyclases class-I signature 1
220341010877	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
220341010878	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
220341010879	domain interfaces; other site
220341010880	active site
220341010881	PS00533 Porphobilinogen deaminase cofactor-binding site
220341010882	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
220341010883	active site
220341010884	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
220341010885	putative protoheme IX biogenesis protein; Provisional; Region: PRK10747
220341010886	HemY protein N-terminus; Region: HemY_N; pfam07219
220341010887	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
220341010888	binding surface
220341010889	TPR motif; other site
220341010890	putative transport protein YifK; Provisional; Region: PRK10746
220341010891	PS00218 Amino acid permeases signature
220341010892	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
220341010893	putative common antigen polymerase; Provisional; Region: PRK02975
220341010894	4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429
220341010895	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
220341010896	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125
220341010897	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
220341010898	inhibitor-cofactor binding pocket; inhibition site
220341010899	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341010900	catalytic residue [active]
220341010901	TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975
220341010902	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
220341010903	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
220341010904	substrate binding site; other site
220341010905	tetramer interface; other site
220341010906	dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217
220341010907	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
220341010908	NAD binding site [chemical binding]; other site
220341010909	substrate binding site [chemical binding]; other site
220341010910	homodimer interface [polypeptide binding]; other site
220341010911	active site
220341010912	UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064
220341010913	UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721
220341010914	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
220341010915	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
220341010916	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
220341010917	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
220341010918	active site
220341010919	homodimer interface [polypeptide binding]; other site
220341010920	lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638
220341010921	Chain length determinant protein; Region: Wzz; pfam02706
220341010922	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
220341010923	undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380
220341010924	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
220341010925	Mg++ binding site [ion binding]; other site
220341010926	putative catalytic motif [active]
220341010927	substrate binding site [chemical binding]; other site
220341010928	transcription termination factor Rho; Provisional; Region: rho; PRK09376
220341010929	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
220341010930	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
220341010931	RNA binding site [nucleotide binding]; other site
220341010932	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
220341010933	multimer interface [polypeptide binding]; other site
220341010934	Walker A motif; other site
220341010935	ATP binding site [chemical binding]; other site
220341010936	Walker B motif; other site
220341010937	PS00017 ATP/GTP-binding site motif A (P-loop)
220341010938	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
220341010939	catalytic residues [active]
220341010940	PS00194 Thioredoxin family active site
220341010941	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
220341010942	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
220341010943	ATP binding site [chemical binding]; other site
220341010944	Mg++ binding site [ion binding]; other site
220341010945	motif III; other site
220341010946	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
220341010947	nucleotide binding region [chemical binding]; other site
220341010948	ATP-binding site [chemical binding]; other site
220341010949	PS00017 ATP/GTP-binding site motif A (P-loop)
220341010950	PS00039 DEAD-box subfamily ATP-dependent helicases signature
220341010951	guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031
220341010952	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
220341010953	ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919
220341010954	Part of AAA domain; Region: AAA_19; pfam13245
220341010955	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
220341010956	PS00017 ATP/GTP-binding site motif A (P-loop)
220341010957	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
220341010958	PS01232 Purine and other phosphorylases family 1 signature
220341010959	peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441
220341010960	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
220341010961	PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature
220341010962	ketol-acid reductoisomerase; Validated; Region: PRK05225
220341010963	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
220341010964	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
220341010965	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341010966	DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716
220341010967	The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430
220341010968	putative dimerization interface [polypeptide binding]; other site
220341010969	PS00044 Bacterial regulatory proteins, lysR family signature
220341010970	Uncharacterized conserved small protein [Function unknown]; Region: COG5606
220341010971	non-specific DNA binding site [nucleotide binding]; other site
220341010972	salt bridge; other site
220341010973	sequence-specific DNA binding site [nucleotide binding]; other site
220341010974	Phage-related protein [Function unknown]; Region: COG4679
220341010975	threonine dehydratase; Reviewed; Region: PRK09224
220341010976	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
220341010977	tetramer interface [polypeptide binding]; other site
220341010978	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341010979	catalytic residue [active]
220341010980	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
220341010981	putative Ile/Val binding site [chemical binding]; other site
220341010982	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
220341010983	putative Ile/Val binding site [chemical binding]; other site
220341010984	PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site
220341010985	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
220341010986	PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 2
220341010987	PS00017 ATP/GTP-binding site motif A (P-loop)
220341010988	PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1
220341010989	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
220341010990	homodimer interface [polypeptide binding]; other site
220341010991	substrate-cofactor binding pocket; other site
220341010992	catalytic residue [active]
220341010993	PS00770 Aminotransferases class-IV signature
220341010994	acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152
220341010995	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
220341010996	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
220341010997	PYR/PP interface [polypeptide binding]; other site
220341010998	dimer interface [polypeptide binding]; other site
220341010999	TPP binding site [chemical binding]; other site
220341011000	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
220341011001	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
220341011002	TPP-binding site [chemical binding]; other site
220341011003	dimer interface [polypeptide binding]; other site
220341011004	PS00187 Thiamine pyrophosphate enzymes signature
220341011005	ilvG operon leader peptide; Provisional; Region: PRK10424
220341011006	bacteriophage
220341011007	integrase; Provisional; Region: int; PHA02601
220341011008	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
220341011009	active site
220341011010	DNA binding site [nucleotide binding]
220341011011	Int/Topo IB signature motif; other site
220341011012	Predicted transcriptional regulator [Transcription]; Region: COG2932
220341011013	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
220341011014	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
220341011015	Catalytic site [active]
220341011016	Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892
220341011017	Protein of unknown function (DUF2732); Region: DUF2732; pfam10809
220341011018	DksA-like zinc finger domain containing protein; Region: PHA00080
220341011019	DNA adenine methylase (dam); Region: dam; TIGR00571
220341011020	PS00092 N-6 Adenine-specific DNA methylases signature
220341011021	Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840
220341011022	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341011023	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341011024	C-terminal putative kinase domain of FAM20 (family with sequence similarity 20), Drosophila Four-jointed (Fj), and related proteins; Region: FAM20_C_like; cl05973
220341011025	The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910
220341011026	portal vertex protein; Provisional; Region: Q; PHA02536
220341011027	terminase ATPase subunit; Provisional; Region: P; PHA02535
220341011028	Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056
220341011029	Phage Terminase; Region: Terminase_1; cl19862
220341011030	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929
220341011031	capsid protein; Provisional; Region: N; PHA02538
220341011032	terminase endonuclease subunit; Provisional; Region: M; PHA02537
220341011033	Phage head completion protein (GPL); Region: Phage_GPL; pfam05926
220341011034	PS00017 ATP/GTP-binding site motif A (P-loop)
220341011035	Phage Tail Protein X; Region: Phage_tail_X; pfam05489
220341011036	Transmembrane protein 223; Region: TMEM223; pfam14640
220341011037	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
220341011038	catalytic residues [active]
220341011039	phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495
220341011040	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
220341011041	Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069
220341011042	Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540
220341011043	baseplate wedge subunit; Provisional; Region: W; PHA02516
220341011044	baseplate assembly protein; Provisional; Region: J; PHA02568
220341011045	Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385
220341011046	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
220341011047	Phage Tail Collar Domain; Region: Collar; pfam07484
220341011048	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
220341011049	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
220341011050	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
220341011051	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
220341011052	catalytic residues [active]
220341011053	catalytic nucleophile [active]
220341011054	Presynaptic Site I dimer interface [polypeptide binding]; other site
220341011055	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
220341011056	Synaptic Flat tetramer interface [polypeptide binding]; other site
220341011057	Synaptic Site I dimer interface [polypeptide binding]; other site
220341011058	DNA binding site [nucleotide binding]
220341011059	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569
220341011060	DNA-binding interface [nucleotide binding]; DNA binding site
220341011061	PS00397 Site-specific recombinases active site
220341011062	PS00398 Site-specific recombinases signature 2
220341011063	major tail sheath protein; Provisional; Region: FI; PHA02560
220341011064	major tail tube protein; Provisional; Region: FII; PHA02600
220341011065	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
220341011066	Phage P2 GpE; Region: Phage_P2_GpE; pfam06528
220341011067	Phage-related tail protein [Function unknown]; Region: COG5283
220341011068	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050
220341011069	Phage protein U [General function prediction only]; Region: COG3499
220341011070	tail protein; Provisional; Region: D; PHA02561
220341011071	Ogr/Delta-like zinc finger; Region: Ogr_Delta; cl19592
220341011072	PS00017 ATP/GTP-binding site motif A (P-loop)
220341011073	PS00676 Sigma-54 interaction domain ATP-binding region B signature
220341011074	IS200
220341011075	Transposase IS200 like; Region: Y1_Tnp; pfam01797
220341011076	hypothetical protein; Provisional; Region: PRK11027
220341011077	transcriptional regulator HdfR; Provisional; Region: PRK03601
220341011078	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341011079	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
220341011080	dimerization interface [polypeptide binding]; other site
220341011081	PS00044 Bacterial regulatory proteins, lysR family signature
220341011082	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
220341011083	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
220341011084	purine monophosphate binding site [chemical binding]; other site
220341011085	dimer interface [polypeptide binding]; other site
220341011086	putative catalytic residues [active]
220341011087	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
220341011088	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
220341011089	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
220341011090	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
220341011091	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
220341011092	PS00184 Phosphoribosylglycinamide synthetase signature
220341011093	transcriptional regulatory protein ZraR; Provisional; Region: PRK10365
220341011094	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
220341011095	active site
220341011096	phosphorylation site [posttranslational modification]
220341011097	intermolecular recognition site; other site
220341011098	dimerization interface [polypeptide binding]; other site
220341011099	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
220341011100	Walker A motif; other site
220341011101	ATP binding site [chemical binding]; other site
220341011102	Walker B motif; other site
220341011103	arginine finger; other site
220341011104	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
220341011105	PS00688 Sigma-54 interaction domain C-terminal part signature
220341011106	PS00676 Sigma-54 interaction domain ATP-binding region B signature
220341011107	PS00675 Sigma-54 interaction domain ATP-binding region A signature
220341011108	sensor protein ZraS; Provisional; Region: PRK10364
220341011109	Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827
220341011110	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
220341011111	dimer interface [polypeptide binding]; other site
220341011112	phosphorylation site [posttranslational modification]
220341011113	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
220341011114	ATP binding site [chemical binding]; other site
220341011115	Mg2+ binding site [ion binding]; other site
220341011116	G-X-G motif; other site
220341011117	zinc resistance protein; Provisional; Region: zraP; PRK11546
220341011118	dimer interface [polypeptide binding]; other site
220341011119	Protein of unknown function (DUF1481); Region: DUF1481; pfam07356
220341011120	histone-like DNA-binding protein HU; Region: HU; cd13831
220341011121	dimer interface [polypeptide binding]; other site
220341011122	DNA binding site [nucleotide binding]
220341011123	PS00045 Bacterial histone-like DNA-binding proteins signature
220341011124	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068
220341011125	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
220341011126	Active_site [active]
220341011127	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
220341011128	substrate binding site [chemical binding]; other site
220341011129	active site
220341011130	PS00907 Uroporphyrinogen decarboxylase signature 2
220341011131	PS00906 Uroporphyrinogen decarboxylase signature 1
220341011132	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
220341011133	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
220341011134	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
220341011135	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
220341011136	putative NADH binding site [chemical binding]; other site
220341011137	putative active site [active]
220341011138	nudix motif; other site
220341011139	putative metal binding site [ion binding]; other site
220341011140	Regulator of sigma D [Transcription]; Region: Rsd; COG3160
220341011141	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
220341011142	ThiC-associated domain; Region: ThiC-associated; pfam13667
220341011143	ThiC family; Region: ThiC; pfam01964
220341011144	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
220341011145	thiamine phosphate binding site [chemical binding]; other site
220341011146	active site
220341011147	pyrophosphate binding site [ion binding]; other site
220341011148	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
220341011149	thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356
220341011150	ATP binding site [chemical binding]; other site
220341011151	substrate interface [chemical binding]; other site
220341011152	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
220341011153	thiS-thiF/thiG interaction site; other site
220341011154	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
220341011155	ThiS interaction site; other site
220341011156	putative active site [active]
220341011157	tetramer interface [polypeptide binding]; other site
220341011158	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
220341011159	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
220341011160	FeS/SAM binding site; other site
220341011161	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
220341011162	region of low G+C (34%)
220341011163	Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609
220341011164	beta and beta' interface [polypeptide binding]; other site
220341011165	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
220341011166	beta' and sigma factor interface [polypeptide binding]; other site
220341011167	Zn-binding [ion binding]; other site
220341011168	active site region [active]
220341011169	catalytic site [active]
220341011170	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
220341011171	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
220341011172	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
220341011173	G-loop; other site
220341011174	DNA binding site [nucleotide binding]
220341011175	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
220341011176	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
220341011177	RPB12 interaction site [polypeptide binding]; other site
220341011178	RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl19478
220341011179	RPB1 interaction site [polypeptide binding]; other site
220341011180	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
220341011181	RPB10 interaction site [polypeptide binding]; other site
220341011182	RPB11 interaction site [polypeptide binding]; other site
220341011183	RPB3 interaction site [polypeptide binding]; other site
220341011184	PS01166 RNA polymerases beta chain signature
220341011185	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
220341011186	core dimer interface [polypeptide binding]; other site
220341011187	peripheral dimer interface [polypeptide binding]; other site
220341011188	L10 interface [polypeptide binding]; other site
220341011189	L11 interface [polypeptide binding]; other site
220341011190	putative EF-Tu interaction site [polypeptide binding]; other site
220341011191	putative EF-G interaction site [polypeptide binding]; other site
220341011192	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
220341011193	23S rRNA interface [nucleotide binding]; other site
220341011194	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
220341011195	PS01109 Ribosomal protein L10 signature
220341011196	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
220341011197	mRNA/rRNA interface [nucleotide binding]; other site
220341011198	PS01199 Ribosomal protein L1 signature
220341011199	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
220341011200	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
220341011201	23S rRNA interface [nucleotide binding]; other site
220341011202	L7/L12 interface [polypeptide binding]; other site
220341011203	putative thiostrepton binding site; other site
220341011204	L25 interface [polypeptide binding]; other site
220341011205	PS00359 Ribosomal protein L11 signature
220341011206	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
220341011207	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
220341011208	putative homodimer interface [polypeptide binding]; other site
220341011209	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
220341011210	heterodimer interface [polypeptide binding]; other site
220341011211	homodimer interface [polypeptide binding]; other site
220341011212	PS01014 Transcription termination factor nusG signature
220341011213	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
220341011214	PS01067 Protein secE/sec61-gamma signature
220341011215	elongation factor Tu; Reviewed; Region: PRK00049
220341011216	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
220341011217	G1 box; other site
220341011218	GEF interaction site [polypeptide binding]; other site
220341011219	GTP/Mg2+ binding site [chemical binding]; other site
220341011220	Switch I region; other site
220341011221	G2 box; other site
220341011222	G3 box; other site
220341011223	Switch II region; other site
220341011224	G4 box; other site
220341011225	G5 box; other site
220341011226	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
220341011227	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
220341011228	Antibiotic Binding Site [chemical binding]; other site
220341011229	PS00301 GTP-binding elongation factors signature
220341011230	PS00017 ATP/GTP-binding site motif A (P-loop)
220341011231	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
220341011232	ATP-binding site [chemical binding]; other site
220341011233	CoA-binding site [chemical binding]; other site
220341011234	Mg2+-binding site [ion binding]; other site
220341011235	PS00017 ATP/GTP-binding site motif A (P-loop)
220341011236	Biotin operon repressor [Transcription]; Region: BirA; COG1654
220341011237	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
220341011238	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
220341011239	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
220341011240	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
220341011241	FAD binding domain; Region: FAD_binding_4; pfam01565
220341011242	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
220341011243	glutamate racemase; Provisional; Region: PRK00865
220341011244	PS00924 Aspartate and glutamate racemases signature 2
220341011245	PS00923 Aspartate and glutamate racemases signature 1
220341011246	vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641
220341011247	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
220341011248	N-terminal plug; other site
220341011249	ligand-binding site [chemical binding]; other site
220341011250	PS01156 TonB-dependent receptor proteins signature 2
220341011251	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
220341011252	Protein of unknown function (DUF3164); Region: DUF3164; pfam11363
220341011253	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
220341011254	S-adenosylmethionine binding site [chemical binding]; other site
220341011255	PS01230 RNA methyltransferase trmA family signature 1
220341011256	PS01231 RNA methyltransferase trmA family signature 2
220341011257	hypothetical protein; Provisional; Region: PRK11056
220341011258	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
220341011259	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
220341011260	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
220341011261	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
220341011262	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
220341011263	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
220341011264	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
220341011265	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341011266	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
220341011267	dimerization interface [polypeptide binding]; other site
220341011268	PS00044 Bacterial regulatory proteins, lysR family signature
220341011269	argininosuccinate lyase; Provisional; Region: PRK04833
220341011270	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
220341011271	active sites [active]
220341011272	tetramer interface [polypeptide binding]; other site
220341011273	PS00163 Fumarate lyases signature
220341011274	AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249
220341011275	nucleotide binding site [chemical binding]; other site
220341011276	N-acetyl-L-glutamate binding site [chemical binding]; other site
220341011277	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
220341011278	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118
220341011279	Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774
220341011280	acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892
220341011281	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
220341011282	metal binding site [ion binding]; metal-binding site
220341011283	putative dimer interface [polypeptide binding]; other site
220341011284	PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1
220341011285	PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2
220341011286	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
220341011287	PS00781 Phosphoenolpyruvate carboxylase active site 1
220341011288	PS00393 Phosphoenolpyruvate carboxylase active site 2
220341011289	hypothetical protein; Provisional; Region: PRK10649
220341011290	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
220341011291	Sulfatase; Region: Sulfatase; pfam00884
220341011292	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341011293	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
220341011294	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341011295	PS00041 Bacterial regulatory proteins, araC family signature
220341011296	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
220341011297	active site
220341011298	intersubunit interactions; other site
220341011299	catalytic residue [active]
220341011300	PS01054 Transaldolase signature 1
220341011301	PS00958 Transaldolase active site
220341011302	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
220341011303	dimer interface [polypeptide binding]; other site
220341011304	active site
220341011305	metal binding site [ion binding]; metal-binding site
220341011306	PS00913 Iron-containing alcohol dehydrogenases signature 1
220341011307	PS00060 Iron-containing alcohol dehydrogenases signature 2
220341011308	PS00687 Aldehyde dehydrogenases glutamic acid active site
220341011309	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
220341011310	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
220341011311	heme binding site [chemical binding]; other site
220341011312	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
220341011313	PS00435 Peroxidases proximal heme-ligand signature
220341011314	PS00436 Peroxidases active site signature
220341011315	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
220341011316	FAD binding site [chemical binding]; other site
220341011317	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
220341011318	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
220341011319	DNA-binding site [nucleotide binding]; DNA binding site
220341011320	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
220341011321	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341011322	homodimer interface [polypeptide binding]; other site
220341011323	catalytic residue [active]
220341011324	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
220341011325	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
220341011326	active site
220341011327	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
220341011328	dimer interface [polypeptide binding]; other site
220341011329	substrate binding site [chemical binding]; other site
220341011330	catalytic residues [active]
220341011331	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
220341011332	dimer interface [polypeptide binding]; other site
220341011333	active site
220341011334	glycine-pyridoxal phosphate binding site [chemical binding]; other site
220341011335	folate binding site [chemical binding]; other site
220341011336	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
220341011337	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
220341011338	active site
220341011339	metal binding site [ion binding]; metal-binding site
220341011340	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
220341011341	PS00786 5'-nucleotidase signature 2
220341011342	bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466
220341011343	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
220341011344	putative catalytic residues [active]
220341011345	putative nucleotide binding site [chemical binding]; other site
220341011346	putative aspartate binding site [chemical binding]; other site
220341011347	ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892
220341011348	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
220341011349	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
220341011350	PS01042 Homoserine dehydrogenase signature
220341011351	PS00324 Aspartokinase signature
220341011352	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
220341011353	homodimer interface [polypeptide binding]; other site
220341011354	substrate-cofactor binding pocket; other site
220341011355	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341011356	catalytic residue [active]
220341011357	PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site
220341011358	Met Repressor, MetJ.  MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490
220341011359	dimerization interface [polypeptide binding]; other site
220341011360	DNA binding site [nucleotide binding]
220341011361	corepressor binding sites; other site
220341011362	conserved hypothetical protein; Region: chp_urease_rgn; TIGR02117
220341011363	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
220341011364	PS01143 Ribosomal protein L31 signature
220341011365	primosome assembly protein PriA; Validated; Region: PRK05580
220341011366	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
220341011367	ATP binding site [chemical binding]; other site
220341011368	putative Mg++ binding site [ion binding]; other site
220341011369	helicase superfamily c-terminal domain; Region: HELICc; smart00490
220341011370	PS00017 ATP/GTP-binding site motif A (P-loop)
220341011371	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
220341011372	DNA binding site [nucleotide binding]
220341011373	DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041
220341011374	domain linker motif; other site
220341011375	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
220341011376	dimerization interface [polypeptide binding]; other site
220341011377	ligand binding site [chemical binding]; other site
220341011378	PS00356 Bacterial regulatory proteins, lacI family signature
220341011379	essential cell division protein FtsN; Provisional; Region: PRK10927
220341011380	Sporulation related domain; Region: SPOR; pfam05036
220341011381	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
220341011382	active site
220341011383	HslU subunit interaction site [polypeptide binding]; other site
220341011384	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
220341011385	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
220341011386	Walker A motif; other site
220341011387	ATP binding site [chemical binding]; other site
220341011388	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
220341011389	Walker B motif; other site
220341011390	arginine finger; other site
220341011391	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
220341011392	PS00017 ATP/GTP-binding site motif A (P-loop)
220341011393	1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962
220341011394	putative active site [active]
220341011395	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
220341011396	septal ring assembly protein ZapB; Provisional; Region: PRK15422
220341011397	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
220341011398	amphipathic channel; other site
220341011399	Asn-Pro-Ala signature motifs; other site
220341011400	PS00221 MIP family signature
220341011401	glycerol kinase; Provisional; Region: glpK; PRK00047
220341011402	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
220341011403	N- and C-terminal domain interface [polypeptide binding]; other site
220341011404	active site
220341011405	MgATP binding site [chemical binding]; other site
220341011406	catalytic site [active]
220341011407	metal binding site [ion binding]; metal-binding site
220341011408	glycerol binding site [chemical binding]; other site
220341011409	homotetramer interface [polypeptide binding]; other site
220341011410	homodimer interface [polypeptide binding]; other site
220341011411	FBP binding site [chemical binding]; other site
220341011412	protein IIAGlc interface [polypeptide binding]; other site
220341011413	PS00933 FGGY family of carbohydrate kinases signature 1
220341011414	PS00445 FGGY family of carbohydrate kinases signature 2
220341011415	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
220341011416	putative active site [active]
220341011417	ferredoxin-NADP reductase; Provisional; Region: PRK10926
220341011418	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
220341011419	FAD binding pocket [chemical binding]; other site
220341011420	FAD binding motif [chemical binding]; other site
220341011421	phosphate binding motif [ion binding]; other site
220341011422	beta-alpha-beta structure motif; other site
220341011423	NAD binding pocket [chemical binding]; other site
220341011424	Predicted membrane protein [Function unknown]; Region: COG3152
220341011425	Protein of unknown function (DUF1454); Region: DUF1454; pfam07305
220341011426	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
220341011427	substrate binding site [chemical binding]; other site
220341011428	dimer interface [polypeptide binding]; other site
220341011429	catalytic triad [active]
220341011430	PS00017 ATP/GTP-binding site motif A (P-loop)
220341011431	PS00171 Triosephosphate isomerase active site
220341011432	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
220341011433	substrate binding site [chemical binding]; other site
220341011434	hexamer interface [polypeptide binding]; other site
220341011435	metal binding site [ion binding]; metal-binding site
220341011436	autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486
220341011437	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
220341011438	putative active site; other site
220341011439	catalytic residue [active]
220341011440	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
220341011441	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
220341011442	ligand binding site [chemical binding]; other site
220341011443	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
220341011444	TM-ABC transporter signature motif; other site
220341011445	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
220341011446	TM-ABC transporter signature motif; other site
220341011447	autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439
220341011448	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
220341011449	Walker A/P-loop; other site
220341011450	ATP binding site [chemical binding]; other site
220341011451	Q-loop/lid; other site
220341011452	ABC transporter signature motif; other site
220341011453	Walker B; other site
220341011454	D-loop; other site
220341011455	H-loop/switch region; other site
220341011456	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
220341011457	PS00211 ABC transporters family signature
220341011458	PS00017 ATP/GTP-binding site motif A (P-loop)
220341011459	transcriptional regulator LsrR; Provisional; Region: PRK15418
220341011460	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
220341011461	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
220341011462	autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939
220341011463	Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775
220341011464	putative N- and C-terminal domain interface [polypeptide binding]; other site
220341011465	putative active site [active]
220341011466	putative MgATP binding site [chemical binding]; other site
220341011467	catalytic site [active]
220341011468	metal binding site [ion binding]; metal-binding site
220341011469	putative carbohydrate binding site [chemical binding]; other site
220341011470	This CDS appears to be a gene remnant which is highly similar to the very C-terminus of Escherichia coli CDP-diacylglycerol pyrophosphatase Cdh SW:CDH_ECOLI (P06282) (251 aa) fasta scores: E(): 9.4e-13, 86.5% id in 37 aa. Note this CDS is also highly similar, but not identical to the very C-terminus of the upstream STY3807 (CDP-diacylglycerol pyrophosphatase).
220341011471	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
220341011472	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
220341011473	DNA-binding site [nucleotide binding]; DNA binding site
220341011474	Alanine racemase, C-terminal domain; Region: Ala_racemase_C; cl08293
220341011475	UTRA domain; Region: UTRA; pfam07702
220341011476	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
220341011477	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
220341011478	putative substrate binding site [chemical binding]; other site
220341011479	putative ATP binding site [chemical binding]; other site
220341011480	PS00584 pfkB family of carbohydrate kinases signature 2
220341011481	CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672
220341011482	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
220341011483	substrate binding pocket [chemical binding]; other site
220341011484	membrane-bound complex binding site; other site
220341011485	hinge residues; other site
220341011486	PS00757 Prokaryotic sulfate-binding proteins signature 2
220341011487	PS00401 Prokaryotic sulfate-binding proteins signature 1
220341011488	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
220341011489	active site
220341011490	ADP/pyrophosphate binding site [chemical binding]; other site
220341011491	dimerization interface [polypeptide binding]; other site
220341011492	allosteric effector site; other site
220341011493	fructose-1,6-bisphosphate binding site; other site
220341011494	PS00433 Phosphofructokinase signature
220341011495	ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509
220341011496	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
220341011497	dimer interface [polypeptide binding]; other site
220341011498	DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955
220341011499	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
220341011500	active site
220341011501	intermolecular recognition site; other site
220341011502	dimerization interface [polypeptide binding]; other site
220341011503	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
220341011504	DNA binding site [nucleotide binding]
220341011505	two-component sensor protein; Provisional; Region: cpxA; PRK09470
220341011506	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
220341011507	dimerization interface [polypeptide binding]; other site
220341011508	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
220341011509	dimer interface [polypeptide binding]; other site
220341011510	phosphorylation site [posttranslational modification]
220341011511	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
220341011512	ATP binding site [chemical binding]; other site
220341011513	Mg2+ binding site [ion binding]; other site
220341011514	G-X-G motif; other site
220341011515	SnoaL-like domain; Region: SnoaL_2; pfam12680
220341011516	6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536
220341011517	MOSC domain; Region: MOSC; pfam03473
220341011518	3-alpha domain; Region: 3-alpha; pfam03475
220341011519	superoxide dismutase; Provisional; Region: PRK10925
220341011520	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
220341011521	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
220341011522	PS00088 Manganese and iron superoxide dismutases signature
220341011523	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
220341011524	DctM-like transporters; Region: DctM; pfam06808
220341011525	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
220341011526	Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178
220341011527	L-rhamnose-proton symport protein (RhaT); Region: RhaT; pfam06379
220341011528	transcriptional activator RhaR; Provisional; Region: PRK13502
220341011529	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
220341011530	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341011531	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341011532	PS00041 Bacterial regulatory proteins, araC family signature
220341011533	transcriptional activator RhaS; Provisional; Region: PRK13503
220341011534	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
220341011535	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341011536	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341011537	PS00041 Bacterial regulatory proteins, araC family signature
220341011538	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
220341011539	N- and C-terminal domain interface [polypeptide binding]; other site
220341011540	active site
220341011541	putative catalytic site [active]
220341011542	metal binding site [ion binding]; metal-binding site
220341011543	ATP binding site [chemical binding]; other site
220341011544	rhamnulokinase; Provisional; Region: rhaB; PRK10640
220341011545	carbohydrate binding site [chemical binding]; other site
220341011546	PS00017 ATP/GTP-binding site motif A (P-loop)
220341011547	L-rhamnose isomerase; Provisional; Region: PRK01076
220341011548	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
220341011549	dimer interface [polypeptide binding]; other site
220341011550	active site
220341011551	metal binding site [ion binding]; metal-binding site
220341011552	PS00913 Iron-containing alcohol dehydrogenases signature 1
220341011553	PS00060 Iron-containing alcohol dehydrogenases signature 2
220341011554	L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625
220341011555	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
220341011556	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
220341011557	non-specific DNA binding site [nucleotide binding]; other site
220341011558	salt bridge; other site
220341011559	sequence-specific DNA binding site [nucleotide binding]; other site
220341011560	Cupin domain; Region: Cupin_2; cl17218
220341011561	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
220341011562	Domain of unknown function (DUF4620); Region: DUF4620; pfam15399
220341011563	Protein of unknown function (DUF3829); Region: DUF3829; pfam12889
220341011564	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341011565	Protein of unknown function (DUF3829); Region: DUF3829; pfam12889
220341011566	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341011567	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
220341011568	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
220341011569	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
220341011570	[4Fe-4S] binding site [ion binding]; other site
220341011571	molybdopterin cofactor binding site; other site
220341011572	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
220341011573	molybdopterin cofactor binding site; other site
220341011574	PS00551 Prokaryotic molybdopterin oxidoreductases signature 1
220341011575	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
220341011576	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
220341011577	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
220341011578	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341011579	formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639
220341011580	formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564
220341011581	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
220341011582	oligomeric interface; other site
220341011583	putative active site [active]
220341011584	homodimer interface [polypeptide binding]; other site
220341011585	Predicted transcriptional regulator [Transcription]; Region: COG3905
220341011586	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
220341011587	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
220341011588	PS01174 Lipolytic enzymes 'G-D-X-G' family, putative serine active site
220341011589	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680
220341011590	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
220341011591	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
220341011592	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
220341011593	non-specific DNA binding site [nucleotide binding]; other site
220341011594	salt bridge; other site
220341011595	sequence-specific DNA binding site [nucleotide binding]; other site
220341011596	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
220341011597	Coenzyme A binding pocket [chemical binding]; other site
220341011598	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500
220341011599	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
220341011600	putative active site [active]
220341011601	dimerization interface [polypeptide binding]; other site
220341011602	putative tRNAtyr binding site [nucleotide binding]; other site
220341011603	hypothetical protein; Reviewed; Region: PRK01637
220341011604	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
220341011605	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
220341011606	motif II; other site
220341011607	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
220341011608	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
220341011609	putative DNA binding site [nucleotide binding]; other site
220341011610	putative Zn2+ binding site [ion binding]; other site
220341011611	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
220341011612	PS00894 Bacterial regulatory proteins
220341011613	Ribokinase-like subgroup B.  Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945
220341011614	substrate binding site [chemical binding]; other site
220341011615	ATP binding site [chemical binding]; other site
220341011616	PS00584 pfkB family of carbohydrate kinases signature 2
220341011617	NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461
220341011618	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
220341011619	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833
220341011620	PS00895 3-hydroxyisobutyrate dehydrogenase signature
220341011621	Class I aldolases; Region: Aldolase_Class_I; cd00945
220341011622	catalytic residue [active]
220341011623	alpha-glucosidase; Provisional; Region: PRK10426
220341011624	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
220341011625	YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594
220341011626	putative active site [active]
220341011627	putative catalytic site [active]
220341011628	putative symporter YagG; Provisional; Region: PRK09669; cl15392
220341011629	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
220341011630	PS00872 Sodium:galactoside symporter family signature
220341011631	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
220341011632	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341011633	putative substrate translocation pore; other site
220341011634	PS00872 Sodium:galactoside symporter family signature
220341011635	outer membrane porin L; Provisional; Region: ompL; PRK09980
220341011636	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116
220341011637	Leucine-rich repeats; other site
220341011638	Substrate binding site [chemical binding]; other site
220341011639	Sulfatase; Region: Sulfatase; cl19157
220341011640	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
220341011641	FeS/SAM binding site; other site
220341011642	pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530
220341011643	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
220341011644	active site
220341011645	motif I; other site
220341011646	motif II; other site
220341011647	GTP-binding protein; Provisional; Region: PRK10218
220341011648	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
220341011649	G1 box; other site
220341011650	putative GEF interaction site [polypeptide binding]; other site
220341011651	GTP/Mg2+ binding site [chemical binding]; other site
220341011652	Switch I region; other site
220341011653	G2 box; other site
220341011654	G3 box; other site
220341011655	Switch II region; other site
220341011656	G4 box; other site
220341011657	G5 box; other site
220341011658	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
220341011659	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
220341011660	PS00301 GTP-binding elongation factors signature
220341011661	glutamine synthetase; Provisional; Region: glnA; PRK09469
220341011662	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
220341011663	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
220341011664	PS00180 Glutamine synthetase signature 1
220341011665	PS00181 Glutamine synthetase putative ATP-binding region signature
220341011666	PS00182 Glutamine synthetase class-I adenylation site
220341011667	nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073
220341011668	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
220341011669	putative active site [active]
220341011670	heme pocket [chemical binding]; other site
220341011671	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
220341011672	dimer interface [polypeptide binding]; other site
220341011673	phosphorylation site [posttranslational modification]
220341011674	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
220341011675	ATP binding site [chemical binding]; other site
220341011676	Mg2+ binding site [ion binding]; other site
220341011677	G-X-G motif; other site
220341011678	nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923
220341011679	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
220341011680	active site
220341011681	phosphorylation site [posttranslational modification]
220341011682	intermolecular recognition site; other site
220341011683	dimerization interface [polypeptide binding]; other site
220341011684	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
220341011685	Walker A motif; other site
220341011686	ATP binding site [chemical binding]; other site
220341011687	Walker B motif; other site
220341011688	arginine finger; other site
220341011689	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
220341011690	PS00675 Sigma-54 interaction domain ATP-binding region A signature
220341011691	PS00676 Sigma-54 interaction domain ATP-binding region B signature
220341011692	PS00688 Sigma-54 interaction domain C-terminal part signature
220341011693	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
220341011694	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
220341011695	FeS/SAM binding site; other site
220341011696	HemN C-terminal domain; Region: HemN_C; pfam06969
220341011697	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078
220341011698	Predicted GTPase [General function prediction only]; Region: COG0218
220341011699	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
220341011700	G1 box; other site
220341011701	GTP/Mg2+ binding site [chemical binding]; other site
220341011702	Switch I region; other site
220341011703	G2 box; other site
220341011704	G3 box; other site
220341011705	Switch II region; other site
220341011706	G4 box; other site
220341011707	G5 box; other site
220341011708	PS00017 ATP/GTP-binding site motif A (P-loop)
220341011709	DNA polymerase I; Provisional; Region: PRK05755
220341011710	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
220341011711	active site
220341011712	metal binding site 1 [ion binding]; metal-binding site
220341011713	putative 5' ssDNA interaction site; other site
220341011714	metal binding site 3; metal-binding site
220341011715	metal binding site 2 [ion binding]; metal-binding site
220341011716	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
220341011717	putative DNA binding site [nucleotide binding]; other site
220341011718	putative metal binding site [ion binding]; other site
220341011719	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
220341011720	active site
220341011721	catalytic site [active]
220341011722	substrate binding site [chemical binding]; other site
220341011723	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
220341011724	active site
220341011725	DNA binding site [nucleotide binding]
220341011726	catalytic site [active]
220341011727	PS00447 DNA polymerase family A signature
220341011728	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
220341011729	putative acyl-acceptor binding pocket; other site
220341011730	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
220341011731	catalytic residues [active]
220341011732	hinge region; other site
220341011733	alpha helical domain; other site
220341011734	PS00194 Thioredoxin family active site
220341011735	serine/threonine protein kinase; Provisional; Region: PRK11768
220341011736	Phosphotransferase enzyme family; Region: APH; pfam01636
220341011737	Protein of unknown function (DUF1040); Region: DUF1040; pfam06288
220341011738	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
220341011739	GTP binding site; other site
220341011740	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
220341011741	Walker A motif; other site
220341011742	PS00017 ATP/GTP-binding site motif A (P-loop)
220341011743	PS00190 Cytochrome c family heme-binding site signature
220341011744	Transcriptional regulators [Transcription]; Region: FadR; COG2186
220341011745	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
220341011746	DNA-binding site [nucleotide binding]; DNA binding site
220341011747	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
220341011748	PS00043 Bacterial regulatory proteins, gntR family signature
220341011749	transcriptional repressor RbsR; Provisional; Region: PRK10423
220341011750	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
220341011751	DNA binding site [nucleotide binding]
220341011752	domain linker motif; other site
220341011753	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
220341011754	dimerization interface [polypeptide binding]; other site
220341011755	ligand binding site [chemical binding]; other site
220341011756	PS00356 Bacterial regulatory proteins, lacI family signature
220341011757	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
220341011758	substrate binding site [chemical binding]; other site
220341011759	dimer interface [polypeptide binding]; other site
220341011760	ATP binding site [chemical binding]; other site
220341011761	PS00584 pfkB family of carbohydrate kinases signature 2
220341011762	PS00583 pfkB family of carbohydrate kinases signature 1
220341011763	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
220341011764	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
220341011765	ligand binding site [chemical binding]; other site
220341011766	dimerization interface [polypeptide binding]; other site
220341011767	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
220341011768	TM-ABC transporter signature motif; other site
220341011769	D-ribose transporter ATP binding protein; Provisional; Region: PRK10762
220341011770	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
220341011771	Walker A/P-loop; other site
220341011772	ATP binding site [chemical binding]; other site
220341011773	Q-loop/lid; other site
220341011774	ABC transporter signature motif; other site
220341011775	Walker B; other site
220341011776	D-loop; other site
220341011777	H-loop/switch region; other site
220341011778	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
220341011779	PS00211 ABC transporters family signature
220341011780	PS00017 ATP/GTP-binding site motif A (P-loop)
220341011781	D-ribose pyranase; Provisional; Region: PRK11797
220341011782	potassium transport protein Kup; Provisional; Region: trkD; PRK10745
220341011783	regulatory ATPase RavA; Provisional; Region: PRK13531
220341011784	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
220341011785	Walker A motif; other site
220341011786	ATP binding site [chemical binding]; other site
220341011787	Walker B motif; other site
220341011788	arginine finger; other site
220341011789	Protein of unknown function (DUF3763); Region: DUF3763; pfam12592
220341011790	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2425
220341011791	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
220341011792	metal ion-dependent adhesion site (MIDAS); other site
220341011793	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
220341011794	dimer interface [polypeptide binding]; other site
220341011795	active site
220341011796	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
220341011797	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
220341011798	putative DNA binding site [nucleotide binding]; other site
220341011799	putative Zn2+ binding site [ion binding]; other site
220341011800	AsnC family; Region: AsnC_trans_reg; pfam01037
220341011801	PS00519 Bacterial regulatory proteins, asnC family signature
220341011802	FMN-binding protein MioC; Provisional; Region: PRK09004
220341011803	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
220341011804	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
220341011805	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
220341011806	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
220341011807	PS01280 Glucose inhibited division protein A family signature 1
220341011808	PS01281 Glucose inhibited division protein A family signature 2
220341011809	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
220341011810	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
220341011811	S-adenosylmethionine binding site [chemical binding]; other site
220341011812	F0F1 ATP synthase subunit I; Validated; Region: PRK08049
220341011813	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
220341011814	PS00449 ATP synthase a subunit signature
220341011815	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
220341011816	PS00605 ATP synthase c subunit signature
220341011817	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
220341011818	F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192
220341011819	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
220341011820	PS00389 ATP synthase delta (OSCP) subunit signature
220341011821	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
220341011822	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
220341011823	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
220341011824	beta subunit interaction interface [polypeptide binding]; other site
220341011825	Walker A motif; other site
220341011826	ATP binding site [chemical binding]; other site
220341011827	Walker B motif; other site
220341011828	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
220341011829	PS00017 ATP/GTP-binding site motif A (P-loop)
220341011830	PS00152 ATP synthase alpha and beta subunits signature
220341011831	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
220341011832	core domain interface [polypeptide binding]; other site
220341011833	delta subunit interface [polypeptide binding]; other site
220341011834	epsilon subunit interface [polypeptide binding]; other site
220341011835	PS00153 ATP synthase gamma subunit signature
220341011836	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
220341011837	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
220341011838	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
220341011839	alpha subunit interaction interface [polypeptide binding]; other site
220341011840	Walker A motif; other site
220341011841	ATP binding site [chemical binding]; other site
220341011842	Walker B motif; other site
220341011843	inhibitor binding site; inhibition site
220341011844	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
220341011845	PS00017 ATP/GTP-binding site motif A (P-loop)
220341011846	PS00152 ATP synthase alpha and beta subunits signature
220341011847	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
220341011848	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
220341011849	gamma subunit interface [polypeptide binding]; other site
220341011850	epsilon subunit interface [polypeptide binding]; other site
220341011851	LBP interface [polypeptide binding]; other site
220341011852	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
220341011853	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451
220341011854	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
220341011855	Substrate binding site; other site
220341011856	Mg++ binding site; other site
220341011857	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
220341011858	active site
220341011859	substrate binding site [chemical binding]; other site
220341011860	CoA binding site [chemical binding]; other site
220341011861	PS00101 Hexapeptide-repeat containing-transferases signature
220341011862	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
220341011863	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
220341011864	glutaminase active site [active]
220341011865	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
220341011866	dimer interface [polypeptide binding]; other site
220341011867	active site
220341011868	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
220341011869	dimer interface [polypeptide binding]; other site
220341011870	active site
220341011871	fimbrial protein; Provisional; Region: lpfA; PRK15289
220341011872	fimbrial chaperone protein; Provisional; Region: lfpB; PRK15290
220341011873	Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345
220341011874	Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753
220341011875	PS00635 Gram-negative pili assembly chaperone signature
220341011876	fimbrial protein StgD; Provisional; Region: PRK15291
220341011877	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
220341011878	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
220341011879	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
220341011880	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
220341011881	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
220341011882	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
220341011883	shikimate binding site; other site
220341011884	NAD(P) binding site [chemical binding]; other site
220341011885	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
220341011886	active site
220341011887	P-loop; other site
220341011888	phosphorylation site [posttranslational modification]
220341011889	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
220341011890	phosphate ABC transporter periplasmic substrate-binding protein PstS; Provisional; Region: PRK10918
220341011891	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
220341011892	substrate binding pocket [chemical binding]; other site
220341011893	membrane-bound complex binding site; other site
220341011894	hinge residues; other site
220341011895	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
220341011896	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341011897	dimer interface [polypeptide binding]; other site
220341011898	conserved gate region; other site
220341011899	putative PBP binding loops; other site
220341011900	ABC-ATPase subunit interface; other site
220341011901	PS00402 Binding-protein-dependent transport systems inner membrane comp sign.
220341011902	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
220341011903	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341011904	dimer interface [polypeptide binding]; other site
220341011905	conserved gate region; other site
220341011906	putative PBP binding loops; other site
220341011907	ABC-ATPase subunit interface; other site
220341011908	PS00402 Binding-protein-dependent transport systems inner membrane comp sign.
220341011909	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
220341011910	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
220341011911	Walker A/P-loop; other site
220341011912	ATP binding site [chemical binding]; other site
220341011913	Q-loop/lid; other site
220341011914	ABC transporter signature motif; other site
220341011915	Walker B; other site
220341011916	D-loop; other site
220341011917	H-loop/switch region; other site
220341011918	PS00017 ATP/GTP-binding site motif A (P-loop)
220341011919	PS00211 ABC transporters family signature
220341011920	transcriptional regulator PhoU; Provisional; Region: PRK11115
220341011921	PhoU domain; Region: PhoU; pfam01895
220341011922	PhoU domain; Region: PhoU; pfam01895
220341011923	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
220341011924	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
220341011925	active site
220341011926	motif I; other site
220341011927	motif II; other site
220341011928	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
220341011929	Sulfate transporter family; Region: Sulfate_transp; cl19250
220341011930	Predicted flavoprotein [General function prediction only]; Region: COG0431
220341011931	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
220341011932	DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216
220341011933	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341011934	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
220341011935	substrate binding pocket [chemical binding]; other site
220341011936	dimerization interface [polypeptide binding]; other site
220341011937	PS00044 Bacterial regulatory proteins, lysR family signature
220341011938	multidrug efflux system protein MdtL; Provisional; Region: PRK10473
220341011939	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341011940	putative substrate translocation pore; other site
220341011941	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
220341011942	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
220341011943	trmE is a tRNA modification GTPase; Region: trmE; cd04164
220341011944	G1 box; other site
220341011945	GTP/Mg2+ binding site [chemical binding]; other site
220341011946	Switch I region; other site
220341011947	G2 box; other site
220341011948	Switch II region; other site
220341011949	G3 box; other site
220341011950	G4 box; other site
220341011951	G5 box; other site
220341011952	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
220341011953	PS00017 ATP/GTP-binding site motif A (P-loop)
220341011954	membrane protein insertase; Provisional; Region: PRK01318
220341011955	YidC periplasmic domain; Region: YidC_periplas; pfam14849
220341011956	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
220341011957	ribonuclease P; Reviewed; Region: rnpA; PRK01732
220341011958	PS00648 Bacterial ribonuclease P protein component signature
220341011959	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
220341011960	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
220341011961	DnaA N-terminal domain; Region: DnaA_N; pfam11638
220341011962	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
220341011963	Walker A motif; other site
220341011964	ATP binding site [chemical binding]; other site
220341011965	Walker B motif; other site
220341011966	arginine finger; other site
220341011967	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
220341011968	DnaA box-binding interface [nucleotide binding]; other site
220341011969	PS00017 ATP/GTP-binding site motif A (P-loop)
220341011970	PS01008 DnaA protein signature
220341011971	DNA polymerase III subunit beta; Validated; Region: PRK05643
220341011972	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
220341011973	putative DNA binding surface [nucleotide binding]; other site
220341011974	dimer interface [polypeptide binding]; other site
220341011975	beta-clamp/clamp loader binding surface; other site
220341011976	beta-clamp/translesion DNA polymerase binding surface; other site
220341011977	recF protein; Region: recf; TIGR00611
220341011978	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
220341011979	Walker A/P-loop; other site
220341011980	ATP binding site [chemical binding]; other site
220341011981	Q-loop/lid; other site
220341011982	ABC transporter signature motif; other site
220341011983	Walker B; other site
220341011984	D-loop; other site
220341011985	H-loop/switch region; other site
220341011986	PS00017 ATP/GTP-binding site motif A (P-loop)
220341011987	PS00617 RecF protein signature 1
220341011988	PS00618 RecF protein signature 2
220341011989	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
220341011990	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
220341011991	ATP binding site [chemical binding]; other site
220341011992	Mg2+ binding site [ion binding]; other site
220341011993	G-X-G motif; other site
220341011994	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
220341011995	anchoring element; other site
220341011996	dimer interface [polypeptide binding]; other site
220341011997	ATP binding site [chemical binding]; other site
220341011998	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
220341011999	active site
220341012000	putative metal-binding site [ion binding]; other site
220341012001	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
220341012002	PS00177 DNA topoisomerase II signature
220341012003	Transcriptional regulator [Transcription]; Region: LysR; COG0583
220341012004	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341012005	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
220341012006	putative dimerization interface [polypeptide binding]; other site
220341012007	PS00044 Bacterial regulatory proteins, lysR family signature
220341012008	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
220341012009	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
220341012010	active site pocket [active]
220341012011	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341012012	D-galactonate transporter; Region: 2A0114; TIGR00893
220341012013	putative substrate translocation pore; other site
220341012014	sugar phosphate phosphatase; Provisional; Region: PRK10513
220341012015	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
220341012016	active site
220341012017	motif I; other site
220341012018	motif II; other site
220341012019	Surface antigen; Region: Bac_surface_Ag; pfam01103
220341012020	Protein of unknown function (DUF4056); Region: DUF4056; pfam13265
220341012021	hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466
220341012022	HAMP domain; Region: HAMP; pfam00672
220341012023	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
220341012024	dimer interface [polypeptide binding]; other site
220341012025	phosphorylation site [posttranslational modification]
220341012026	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
220341012027	ATP binding site [chemical binding]; other site
220341012028	Mg2+ binding site [ion binding]; other site
220341012029	G-X-G motif; other site
220341012030	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
220341012031	active site
220341012032	phosphorylation site [posttranslational modification]
220341012033	intermolecular recognition site; other site
220341012034	dimerization interface [polypeptide binding]; other site
220341012035	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
220341012036	putative binding surface; other site
220341012037	active site
220341012038	PS00017 ATP/GTP-binding site motif A (P-loop)
220341012039	TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936
220341012040	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
220341012041	PS00190 Cytochrome c family heme-binding site signature
220341012042	PS00190 Cytochrome c family heme-binding site signature
220341012043	PS00190 Cytochrome c family heme-binding site signature
220341012044	trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102
220341012045	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
220341012046	molybdopterin cofactor binding site [chemical binding]; other site
220341012047	substrate binding site [chemical binding]; other site
220341012048	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
220341012049	molybdopterin cofactor binding site; other site
220341012050	PS00490 Prokaryotic molybdopterin oxidoreductases signature 2
220341012051	PS00932 Prokaryotic molybdopterin oxidoreductases signature 3
220341012052	chaperone protein TorD; Validated; Region: torD; PRK04976
220341012053	Haem-binding domain; Region: Haem_bd; pfam14376
220341012054	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
220341012055	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
220341012056	PS00190 Cytochrome c family heme-binding site signature
220341012057	PS00190 Cytochrome c family heme-binding site signature
220341012058	PS00190 Cytochrome c family heme-binding site signature
220341012059	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
220341012060	Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231
220341012061	Walker A/P-loop; other site
220341012062	ATP binding site [chemical binding]; other site
220341012063	Q-loop/lid; other site
220341012064	ABC transporter signature motif; other site
220341012065	Walker B; other site
220341012066	D-loop; other site
220341012067	H-loop/switch region; other site
220341012068	PS00017 ATP/GTP-binding site motif A (P-loop)
220341012069	PS00211 ABC transporters family signature
220341012070	heme exporter protein CcmB; Region: ccmB; TIGR01190
220341012071	heme exporter protein CcmC; Region: ccmC; TIGR01191
220341012072	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
220341012073	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13150
220341012074	c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353
220341012075	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
220341012076	catalytic residues [active]
220341012077	central insert; other site
220341012078	PS00194 Thioredoxin family active site
220341012079	Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088
220341012080	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
220341012081	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
220341012082	binding surface
220341012083	TPR motif; other site
220341012084	Protein of unknown function (DUF3748); Region: DUF3748; pfam12566
220341012085	PS00017 ATP/GTP-binding site motif A (P-loop)
220341012086	hypothetical protein; Provisional; Region: PRK11616
220341012087	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341012088	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
220341012089	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
220341012090	putative dimer interface [polypeptide binding]; other site
220341012091	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
220341012092	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
220341012093	putative dimer interface [polypeptide binding]; other site
220341012094	putative transporter; Validated; Region: PRK03818
220341012095	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
220341012096	TrkA-C domain; Region: TrkA_C; pfam02080
220341012097	TrkA-C domain; Region: TrkA_C; pfam02080
220341012098	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
220341012099	Domain of unknown function (DUF202); Region: DUF202; pfam02656
220341012100	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
220341012101	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
220341012102	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
220341012103	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
220341012104	catalytic residue [active]
220341012105	PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site
220341012106	permease DsdX; Provisional; Region: PRK09921
220341012107	GntP family permease; Region: GntP_permease; pfam02447
220341012108	DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086
220341012109	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341012110	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
220341012111	dimerization interface [polypeptide binding]; other site
220341012112	substrate binding pocket [chemical binding]; other site
220341012113	PS00044 Bacterial regulatory proteins, lysR family signature
220341012114	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
220341012115	multidrug resistance protein D; Provisional; Region: emrD; PRK11652
220341012116	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341012117	putative substrate translocation pore; other site
220341012118	ilvB operon leader peptide; Provisional; Region: PRK10214
220341012119	acetolactate synthase catalytic subunit; Validated; Region: PRK08155
220341012120	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
220341012121	PYR/PP interface [polypeptide binding]; other site
220341012122	dimer interface [polypeptide binding]; other site
220341012123	TPP binding site [chemical binding]; other site
220341012124	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
220341012125	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
220341012126	TPP-binding site [chemical binding]; other site
220341012127	dimer interface [polypeptide binding]; other site
220341012128	PS00187 Thiamine pyrophosphate enzymes signature
220341012129	Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440
220341012130	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
220341012131	putative valine binding site [chemical binding]; other site
220341012132	dimer interface [polypeptide binding]; other site
220341012133	DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681
220341012134	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
220341012135	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
220341012136	PS00894 Bacterial regulatory proteins, deoR family signature
220341012137	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
220341012138	substrate binding site [chemical binding]; other site
220341012139	dimer interface [polypeptide binding]; other site
220341012140	ATP binding site [chemical binding]; other site
220341012141	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
220341012142	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341012143	putative substrate translocation pore; other site
220341012144	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341012145	deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269
220341012146	active site
220341012147	catalytic residues [active]
220341012148	DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360
220341012149	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
220341012150	active site
220341012151	phosphorylation site [posttranslational modification]
220341012152	intermolecular recognition site; other site
220341012153	dimerization interface [polypeptide binding]; other site
220341012154	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
220341012155	DNA binding residues [nucleotide binding]
220341012156	dimerization interface [polypeptide binding]; other site
220341012157	sensory histidine kinase UhpB; Provisional; Region: PRK11644
220341012158	MASE1; Region: MASE1; pfam05231
220341012159	Histidine kinase; Region: HisKA_3; pfam07730
220341012160	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
220341012161	ATP binding site [chemical binding]; other site
220341012162	Mg2+ binding site [ion binding]; other site
220341012163	G-X-G motif; other site
220341012164	regulatory protein UhpC; Provisional; Region: PRK11663
220341012165	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341012166	putative substrate translocation pore; other site
220341012167	PS00942 glpT family of transporters signature
220341012168	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
220341012169	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341012170	putative substrate translocation pore; other site
220341012171	PS00942 glpT family of transporters signature
220341012172	Protein of unknown function (DUF1198); Region: DUF1198; pfam06711
220341012173	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
220341012174	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
220341012175	DNA-binding site [nucleotide binding]; DNA binding site
220341012176	UTRA domain; Region: UTRA; pfam07702
220341012177	PS00043 Bacterial regulatory proteins, gntR family signature
220341012178	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
220341012179	active site
220341012180	P-loop; other site
220341012181	phosphorylation site [posttranslational modification]
220341012182	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
220341012183	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
220341012184	uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774
220341012185	putative N- and C-terminal domain interface [polypeptide binding]; other site
220341012186	putative active site [active]
220341012187	putative MgATP binding site [chemical binding]; other site
220341012188	catalytic site [active]
220341012189	metal binding site [ion binding]; metal-binding site
220341012190	putative carbohydrate binding site [chemical binding]; other site
220341012191	PS00190 Cytochrome c family heme-binding site signature
220341012192	Pseudogene, putative sugar-bisphosphate aldolase. Similar to Escherichia coli tagatose-bisphosphate aldolase SW:AGAY_ECOLI (P42908) (286 aa) fasta scores: E(): 2e-27, 42.4% id in 205 aa, and to Vibrio furnissii putative aldolase manF TR:P96167 (EMBL:U65015) (287 aa) fasta scores: E(): 3.5e-25, 41.7% id in 204 aa. Contains a STOP at codon 68. The sequence has been checked and is believed to be correct
220341012193	PS00602 Fructose-bisphosphate aldolase class-II signature 1
220341012194	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
220341012195	dimerization domain swap beta strand [polypeptide binding]; other site
220341012196	regulatory protein interface [polypeptide binding]; other site
220341012197	active site
220341012198	regulatory phosphorylation site [posttranslational modification]; other site
220341012199	PS00369 PTS HPR component histidine phosphorylation site signature
220341012200	Predicted transcriptional regulator [Transcription]; Region: COG2944
220341012201	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
220341012202	non-specific DNA binding site [nucleotide binding]; other site
220341012203	salt bridge; other site
220341012204	sequence-specific DNA binding site [nucleotide binding]; other site
220341012205	Pseudogene, hypothetical protein. Similar to Coxiella burnetii hypothetical TR:Q45858 (EMBL:X85964) (151 aa) fasta scores: E(): 0.0015, 50.0% id in 46 aa, and to Neisseria meningitidis hypothetical protein NMB1890 NMB1890 TR:AAF42224 (122 aa) fasta scores: E(): 0.0017, 51.1% id in 45 aa. COntains aframeshift after codon 59. The sequence has been checked and is believed to be correct
220341012206	ribonucleoside transporter; Reviewed; Region: nepI; PRK10213
220341012207	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341012208	putative substrate translocation pore; other site
220341012209	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232
220341012210	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
220341012211	PS00572 Glycosyl hydrolases family 1 active site
220341012212	Pseudogene, putative transcriptional regulator. Similar to Bacillus subtilis transcriptional regulatory protein LevR SW:LEVR_BACSU (P23914) (938 aa) fasta scores: E(): 0, 28.3% id in 847 aa. Contains a frameshift after codon 69. The sequence has been checked and is believed to be correct. Several alternative start sites exist
220341012213	PS00690 DEAH-box subfamily ATP-dependent helicases signature
220341012214	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
220341012215	active pocket/dimerization site; other site
220341012216	active site
220341012217	phosphorylation site [posttranslational modification]
220341012218	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
220341012219	active site
220341012220	phosphorylation site [posttranslational modification]
220341012221	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
220341012222	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
220341012223	uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437
220341012224	conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581
220341012225	hypothetical protein; Provisional; Region: PRK09956
220341012226	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
220341012227	EamA-like transporter family; Region: EamA; pfam00892
220341012228	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
220341012229	EamA-like transporter family; Region: EamA; pfam00892
220341012230	Salmonella Pathogenicity Island 3
220341012231	magnesium transport protein MgtC; Provisional; Region: PRK15385
220341012232	MgtC family; Region: MgtC; pfam02308
220341012233	magnesium-transporting ATPase; Provisional; Region: PRK15122
220341012234	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
220341012235	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
220341012236	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
220341012237	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
220341012238	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
220341012239	PS00154 E1-E2 ATPases phosphorylation site
220341012240	Identical to Salmonella typhimurium hypothetical protein CigR TR:Q9Z621 (EMBL:AF106566) (159 aa). Contains a possible N-terminal signal sequence. Note located within Salmonella pathogenicity island 3. Contains a framshift after codon 115. The sequence has been checked and is believed to be correct
220341012241	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
220341012242	catalytic triad [active]
220341012243	conserved cis-peptide bond; other site
220341012244	DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475
220341012245	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
220341012246	This CDS appears to be a gene remnant which is similar to several transposases including: Salmonella enteritidis IS1351 transposase OrfA TR:O06945 (EMBL:Z83734) (88 aa) fasta scores: E(): 1.3e-09, 68.2% id in 44 aa, Yersinia enterocolitica IS1400 transposase A TR:Q9X9H8 (EMBL:AJ132945) (96 aa) fasta scores: E(): 7.4e-09, 63.6% id in 44 aa, and to Yersinia pestis putative IS element protein LcrS TR:AAC69827 (EMBL:AF074612) (88 aa) fasta scores: E(): 3e-05, 50.0% id in 44 aa
220341012247	This CDS appears to be a gene remnant and is similar to several putative insertion sequence transposases including: Escherichia coli hypothetical protein TR:Q57247 (EMBL:D83536) (112 aa) fasta scores: E(): 7.3e-13, 79.5% id in 44 aa, Pseudomonas syringae pv. eriobotryae TR:Q9R9F1 (EMBL:AB018553) (160 aa) fasta scores: E(): 3.6e-09, 45.8% id in 72 aa, and Lactococcus lactis insertion sequence IS904 TR:Q48710 (EMBL:D00696) (96 aa) fasta scores: E(): 0.00036, 38.6% id in 44 aa
220341012248	Virulence protein [General function prediction only]; Region: COG3943
220341012249	putative transporter; Provisional; Region: PRK11462
220341012250	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
220341012251	PS00872 Sodium:galactoside symporter family signature
220341012252	putative alpha-glucosidase; Provisional; Region: PRK10658
220341012253	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
220341012254	YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593
220341012255	active site
220341012256	homotrimer interface [polypeptide binding]; other site
220341012257	catalytic site [active]
220341012258	homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site
220341012259	AsmA family; Region: AsmA; pfam05170
220341012260	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
220341012261	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
220341012262	Sulfate transporter family; Region: Sulfate_transp; cl19250
220341012263	PS01116 Xanthine/uracil permeases family signature
220341012264	Sodium/glutamate symporter; Region: Glt_symporter; cl19414
220341012265	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
220341012266	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
220341012267	generic binding surface II; other site
220341012268	ssDNA binding site; other site
220341012269	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
220341012270	ATP binding site [chemical binding]; other site
220341012271	putative Mg++ binding site [ion binding]; other site
220341012272	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
220341012273	nucleotide binding region [chemical binding]; other site
220341012274	ATP-binding site [chemical binding]; other site
220341012275	PS00017 ATP/GTP-binding site motif A (P-loop)
220341012276	tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081
220341012277	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
220341012278	SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
220341012279	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
220341012280	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
220341012281	Zn2+ binding site [ion binding]; other site
220341012282	Mg2+ binding site [ion binding]; other site
220341012283	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
220341012284	synthetase active site [active]
220341012285	NTP binding site [chemical binding]; other site
220341012286	metal binding site [ion binding]; metal-binding site
220341012287	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
220341012288	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
220341012289	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
220341012290	Guanylate kinase; Region: Guanylate_kin; pfam00625
220341012291	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
220341012292	catalytic site [active]
220341012293	G-X2-G-X-G-K; other site
220341012294	PS00856 Guanylate kinase signature
220341012295	PS01055 NAD-dependent DNA ligase signature 1
220341012296	PS01056 NAD-dependent DNA ligase signature 2
220341012297	Predicted membrane protein [Function unknown]; Region: COG2860
220341012298	UPF0126 domain; Region: UPF0126; pfam03458
220341012299	UPF0126 domain; Region: UPF0126; pfam03458
220341012300	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
220341012301	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341012302	Transcriptional regulator [Transcription]; Region: LysR; COG0583
220341012303	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341012304	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
220341012305	dimerization interface [polypeptide binding]; other site
220341012306	PS00044 Bacterial regulatory proteins, lysR family signature
220341012307	hypothetical protein; Provisional; Region: PRK11820
220341012308	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
220341012309	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
220341012310	ribonuclease PH; Reviewed; Region: rph; PRK00173
220341012311	Ribonuclease PH; Region: RNase_PH_bact; cd11362
220341012312	hexamer interface [polypeptide binding]; other site
220341012313	active site
220341012314	PS01277 Ribonuclease PH signature
220341012315	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
220341012316	active site
220341012317	PS00103 Purine/pyrimidine phosphoribosyl transferases signature
220341012318	division inhibitor protein; Provisional; Region: slmA; PRK09480
220341012319	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
220341012320	PS01081 Bacterial regulatory proteins, tetR family signature
220341012321	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
220341012322	trimer interface [polypeptide binding]; other site
220341012323	active site
220341012324	PS00334 Myb DNA-binding domain repeat signature 2
220341012325	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
220341012326	Flavoprotein; Region: Flavoprotein; cl19190
220341012327	DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127
220341012328	hypothetical protein; Reviewed; Region: PRK00024
220341012329	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
220341012330	MPN+ (JAMM) motif; other site
220341012331	Zinc-binding site [ion binding]; other site
220341012332	PS01302 DNA repair protein radC family signature
220341012333	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
220341012334	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
220341012335	PS00582 Ribosomal protein L33 signature
220341012336	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
220341012337	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
220341012338	DNA binding site [nucleotide binding]
220341012339	catalytic residue [active]
220341012340	H2TH interface [polypeptide binding]; other site
220341012341	putative catalytic residues [active]
220341012342	turnover-facilitating residue; other site
220341012343	intercalation triad [nucleotide binding]; other site
220341012344	8OG recognition residue [nucleotide binding]; other site
220341012345	putative reading head residues; other site
220341012346	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
220341012347	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
220341012348	PS01242 Formamidopyrimidine-DNA glycosylase signature
220341012349	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
220341012350	active site
220341012351	(T/H)XGH motif; other site
220341012352	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
220341012353	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
220341012354	Glycosyl transferases group 1; Region: Glycos_transf_1; cl19138
220341012355	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
220341012356	putative active site [active]
220341012357	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
220341012358	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
220341012359	lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123
220341012360	UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922
220341012361	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
220341012362	putative ADP-binding pocket [chemical binding]; other site
220341012363	lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171
220341012364	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
220341012365	Ligand binding site; other site
220341012366	metal-binding site
220341012367	Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437
220341012368	lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171
220341012369	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
220341012370	Ligand binding site; other site
220341012371	metal-binding site
220341012372	Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437
220341012373	lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10359
220341012374	lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822
220341012375	lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484
220341012376	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
220341012377	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
220341012378	O-antigen ligase RfaL; Provisional; Region: PRK15487
220341012379	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
220341012380	putative active site [active]
220341012381	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
220341012382	putative active site [active]
220341012383	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
220341012384	ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150
220341012385	NADP binding site [chemical binding]; other site
220341012386	homopentamer interface [polypeptide binding]; other site
220341012387	substrate binding site [chemical binding]; other site
220341012388	active site
220341012389	8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858
220341012390	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
220341012391	substrate-cofactor binding pocket; other site
220341012392	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341012393	catalytic residue [active]
220341012394	PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site
220341012395	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
220341012396	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
220341012397	NAD(P) binding site [chemical binding]; other site
220341012398	PS00059 Zinc-containing alcohol dehydrogenases signature
220341012399	putative glycosyl transferase; Provisional; Region: PRK10073
220341012400	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
220341012401	active site
220341012402	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
220341012403	NodB motif; other site
220341012404	putative active site [active]
220341012405	putative catalytic site [active]
220341012406	Zn binding site [ion binding]; other site
220341012407	AmiB activator; Provisional; Region: PRK11637
220341012408	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
220341012409	Peptidase family M23; Region: Peptidase_M23; pfam01551
220341012410	phosphoglyceromutase; Provisional; Region: PRK05434
220341012411	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
220341012412	active site residue [active]
220341012413	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
220341012414	GSH binding site [chemical binding]; other site
220341012415	catalytic residues [active]
220341012416	PS00195 Glutaredoxin active site
220341012417	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
220341012418	SecA binding site; other site
220341012419	Preprotein binding site; other site
220341012420	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
220341012421	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
220341012422	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
220341012423	PS00957 NAD-dependent glycerol-3-phosphate dehydrogenase signature
220341012424	serine acetyltransferase; Provisional; Region: cysE; PRK11132
220341012425	Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971
220341012426	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
220341012427	trimer interface [polypeptide binding]; other site
220341012428	active site
220341012429	substrate binding site [chemical binding]; other site
220341012430	CoA binding site [chemical binding]; other site
220341012431	PS00101 Hexapeptide-repeat containing-transferases signature
220341012432	Pseudogene, possible glucarate transporter. Similar to Bacillus subtilis probable glucarate transporter gudP SW:GUDP_BACSU (P42237) (455 aa) fasta scores: E(): 0, 53.1% id in 273 aa, and to Escherichia coli probable glucarate transporter gudP or b2789 SW:GUDP_ECOLI (Q46916) (450 aa) fasta scores: E(): 0, 49.5% id in 279 aa. Contains amber stop codon. The sequence has been checked and is believed to be correct
220341012433	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
220341012434	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
220341012435	active site pocket [active]
220341012436	PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2
220341012437	Transcriptional regulators [Transcription]; Region: PurR; COG1609
220341012438	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
220341012439	DNA binding site [nucleotide binding]
220341012440	domain linker motif; other site
220341012441	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
220341012442	putative dimerization interface [polypeptide binding]; other site
220341012443	putative ligand binding site [chemical binding]; other site
220341012444	putative rRNA methylase; Provisional; Region: PRK10358
220341012445	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
220341012446	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
220341012447	active site
220341012448	substrate binding site [chemical binding]; other site
220341012449	FMN binding site [chemical binding]; other site
220341012450	putative catalytic residues [active]
220341012451	PS00017 ATP/GTP-binding site motif A (P-loop)
220341012452	PS00557 FMN-dependent alpha-hydroxy acid dehydrogenases active site
220341012453	DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421
220341012454	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
220341012455	DNA-binding site [nucleotide binding]; DNA binding site
220341012456	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
220341012457	PS00043 Bacterial regulatory proteins, gntR family signature
220341012458	L-lactate permease; Provisional; Region: PRK10420
220341012459	Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295
220341012460	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
220341012461	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
220341012462	trimer interface [polypeptide binding]; other site
220341012463	Coiled stalk of trimeric autotransporter adhesin; Region: YadA_stalk; pfam05662
220341012464	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
220341012465	trimer interface [polypeptide binding]; other site
220341012466	YadA-like C-terminal region; Region: YadA_anchor; pfam03895
220341012467	Protein of unknown function (DUF3251); Region: DUF3251; cl08186
220341012468	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341012469	hypothetical protein; Provisional; Region: PRK11020
220341012470	mannitol repressor protein; Provisional; Region: mtlR; PRK11001
220341012471	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
220341012472	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
220341012473	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
220341012474	PS00974 Mannitol dehydrogenases signature
220341012475	PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083
220341012476	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
220341012477	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
220341012478	active site
220341012479	P-loop; other site
220341012480	phosphorylation site [posttranslational modification]
220341012481	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
220341012482	active site
220341012483	phosphorylation site [posttranslational modification]
220341012484	PS00372 PTS EIIA domains phosphorylation site signature 2
220341012485	putative glutathione S-transferase; Provisional; Region: PRK10357
220341012486	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
220341012487	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
220341012488	dimer interface [polypeptide binding]; other site
220341012489	N-terminal domain interface [polypeptide binding]; other site
220341012490	putative substrate binding pocket (H-site) [chemical binding]; other site
220341012491	selenocysteine synthase; Provisional; Region: PRK04311
220341012492	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
220341012493	L-seryl-tRNA selenium transferase; Region: SelA; pfam03841
220341012494	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
220341012495	catalytic residue [active]
220341012496	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
220341012497	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
220341012498	G1 box; other site
220341012499	putative GEF interaction site [polypeptide binding]; other site
220341012500	GTP/Mg2+ binding site [chemical binding]; other site
220341012501	Switch I region; other site
220341012502	G2 box; other site
220341012503	G3 box; other site
220341012504	Switch II region; other site
220341012505	G4 box; other site
220341012506	G5 box; other site
220341012507	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
220341012508	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
220341012509	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
220341012510	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
220341012511	PS00017 ATP/GTP-binding site motif A (P-loop)
220341012512	PS00301 GTP-binding elongation factors signature
220341012513	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
220341012514	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
220341012515	nucleotide binding site [chemical binding]; other site
220341012516	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like; Region: ALDH_ACDHII_AcoD-like; cd07559
220341012517	NAD(P) binding site [chemical binding]; other site
220341012518	catalytic residues [active]
220341012519	PS00687 Aldehyde dehydrogenases glutamic acid active site
220341012520	PS00070 Aldehyde dehydrogenases cysteine active site
220341012521	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
220341012522	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
220341012523	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
220341012524	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341012525	PS00041 Bacterial regulatory proteins, araC family signature
220341012526	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
220341012527	intersubunit interface [polypeptide binding]; other site
220341012528	active site
220341012529	Zn2+ binding site [ion binding]; other site
220341012530	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
220341012531	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
220341012532	AP (apurinic/apyrimidinic) site pocket; other site
220341012533	DNA interaction; other site
220341012534	Metal-binding active site; metal-binding site
220341012535	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
220341012536	active site
220341012537	dimer interface [polypeptide binding]; other site
220341012538	magnesium binding site [ion binding]; other site
220341012539	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
220341012540	L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802
220341012541	putative N- and C-terminal domain interface [polypeptide binding]; other site
220341012542	putative active site [active]
220341012543	MgATP binding site [chemical binding]; other site
220341012544	catalytic site [active]
220341012545	metal binding site [ion binding]; metal-binding site
220341012546	putative xylulose binding site [chemical binding]; other site
220341012547	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
220341012548	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
220341012549	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
220341012550	PS00017 ATP/GTP-binding site motif A (P-loop)
220341012551	IS1 transposase; Region: DDE_Tnp_IS1; pfam03400
220341012552	L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060
220341012553	DctM-like transporters; Region: DctM; pfam06808
220341012554	2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877
220341012555	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
220341012556	2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260
220341012557	Transcriptional regulator [Transcription]; Region: IclR; COG1414
220341012558	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
220341012559	Bacterial transcriptional regulator; Region: IclR; pfam01614
220341012560	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
220341012561	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341012562	valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440
220341012563	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
220341012564	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341012565	homodimer interface [polypeptide binding]; other site
220341012566	catalytic residue [active]
220341012567	alpha-amylase; Reviewed; Region: malS; PRK09505
220341012568	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
220341012569	active site
220341012570	catalytic site [active]
220341012571	hypothetical protein; Provisional; Region: PRK10356
220341012572	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
220341012573	Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543
220341012574	putative dimerization interface [polypeptide binding]; other site
220341012575	Transcriptional regulators [Transcription]; Region: PurR; COG1609
220341012576	putative ligand binding site [chemical binding]; other site
220341012577	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341012578	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
220341012579	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341012580	xylose isomerase; Provisional; Region: PRK05474
220341012581	PS00173 Xylose isomerase signature 2
220341012582	PS00172 Xylose isomerase signature 1
220341012583	xylulokinase; Provisional; Region: PRK15027
220341012584	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
220341012585	N- and C-terminal domain interface [polypeptide binding]; other site
220341012586	active site
220341012587	MgATP binding site [chemical binding]; other site
220341012588	catalytic site [active]
220341012589	metal binding site [ion binding]; metal-binding site
220341012590	xylulose binding site [chemical binding]; other site
220341012591	homodimer interface [polypeptide binding]; other site
220341012592	PS00933 FGGY family of carbohydrate kinases signature 1
220341012593	PS00445 FGGY family of carbohydrate kinases signature 2
220341012594	Predicted membrane protein [Function unknown]; Region: COG4682
220341012595	yiaA/B two helix domain; Region: YiaAB; pfam05360
220341012596	yiaA/B two helix domain; Region: YiaAB; pfam05360
220341012597	YsaB-like lipoprotein; Region: YsaB; pfam13983
220341012598	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341012599	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
220341012600	dimer interface [polypeptide binding]; other site
220341012601	motif 1; other site
220341012602	active site
220341012603	motif 2; other site
220341012604	motif 3; other site
220341012605	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2
220341012606	glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211
220341012607	Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092
220341012608	DALR anticodon binding domain; Region: DALR_1; pfam05746
220341012609	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
220341012610	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
220341012611	Coenzyme A binding pocket [chemical binding]; other site
220341012612	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
220341012613	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
220341012614	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
220341012615	DNA-binding site [nucleotide binding]; DNA binding site
220341012616	RNA-binding motif; other site
220341012617	PS00352 'Cold-shock' DNA-binding domain signature
220341012618	Predicted transcriptional regulator [Transcription]; Region: COG2944
220341012619	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
220341012620	salt bridge; other site
220341012621	non-specific DNA binding site [nucleotide binding]; other site
220341012622	sequence-specific DNA binding site [nucleotide binding]; other site
220341012623	Protein of unknown function (DUF3053); Region: DUF3053; pfam11254
220341012624	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
220341012625	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
220341012626	dimerization interface [polypeptide binding]; other site
220341012627	ligand binding site [chemical binding]; other site
220341012628	NADP binding site [chemical binding]; other site
220341012629	catalytic site [active]
220341012630	PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3
220341012631	PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2
220341012632	putative outer membrane lipoprotein; Provisional; Region: PRK10510
220341012633	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
220341012634	ligand binding site [chemical binding]; other site
220341012635	PS01068 OmpA-like domain
220341012636	PS00017 ATP/GTP-binding site motif A (P-loop)
220341012637	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341012638	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
220341012639	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
220341012640	molybdopterin cofactor binding site [chemical binding]; other site
220341012641	substrate binding site [chemical binding]; other site
220341012642	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
220341012643	molybdopterin cofactor binding site; other site
220341012644	PS00490 Prokaryotic molybdopterin oxidoreductases signature 2
220341012645	PS00017 ATP/GTP-binding site motif A (P-loop)
220341012646	PS00932 Prokaryotic molybdopterin oxidoreductases signature 3
220341012647	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
220341012648	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
220341012649	Coenzyme A binding pocket [chemical binding]; other site
220341012650	3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353
220341012651	Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571
220341012652	phosphoethanolamine transferase; Provisional; Region: PRK11560
220341012653	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
220341012654	Sulfatase; Region: Sulfatase; pfam00884
220341012655	Transcriptional regulators [Transcription]; Region: PurR; COG1609
220341012656	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
220341012657	DNA binding site [nucleotide binding]
220341012658	domain linker motif; other site
220341012659	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_8; cd06287
220341012660	putative dimerization interface [polypeptide binding]; other site
220341012661	putative ligand binding site [chemical binding]; other site
220341012662	PS00356 Bacterial regulatory proteins, lacI family signature
220341012663	Arylsulfotransferase (ASST); Region: Arylsulfotrans; cl19972
220341012664	antimicrobial peptide ABC transporter periplasmic binding protein SapA; Provisional; Region: PRK15109
220341012665	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
220341012666	peptide binding site [polypeptide binding]; other site
220341012667	PS01040 Bacterial extracellular solute-binding proteins, family 5 signature
220341012668	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
220341012669	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341012670	dimer interface [polypeptide binding]; other site
220341012671	conserved gate region; other site
220341012672	putative PBP binding loops; other site
220341012673	ABC-ATPase subunit interface; other site
220341012674	PS00402 Binding-protein-dependent transport systems inner membrane comp sign.
220341012675	dipeptide transporter; Provisional; Region: PRK10913
220341012676	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
220341012677	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341012678	dimer interface [polypeptide binding]; other site
220341012679	conserved gate region; other site
220341012680	putative PBP binding loops; other site
220341012681	ABC-ATPase subunit interface; other site
220341012682	dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022
220341012683	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
220341012684	Walker A/P-loop; other site
220341012685	ATP binding site [chemical binding]; other site
220341012686	Q-loop/lid; other site
220341012687	ABC transporter signature motif; other site
220341012688	Walker B; other site
220341012689	D-loop; other site
220341012690	H-loop/switch region; other site
220341012691	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
220341012692	PS00017 ATP/GTP-binding site motif A (P-loop)
220341012693	PS00211 ABC transporters family signature
220341012694	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
220341012695	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
220341012696	Walker A/P-loop; other site
220341012697	ATP binding site [chemical binding]; other site
220341012698	Q-loop/lid; other site
220341012699	ABC transporter signature motif; other site
220341012700	Walker B; other site
220341012701	D-loop; other site
220341012702	H-loop/switch region; other site
220341012703	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
220341012704	PS00017 ATP/GTP-binding site motif A (P-loop)
220341012705	PS00211 ABC transporters family signature
220341012706	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
220341012707	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
220341012708	Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940
220341012709	cellulose synthase operon protein YhjU; Region: cellulose_yhjU; TIGR03368
220341012710	Protein of unknown function (DUF2636); Region: DUF2636; pfam11120
220341012711	cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045
220341012712	Protein of unknown function (DUF2629); Region: DUF2629; pfam10945
220341012713	cell division protein; Provisional; Region: PRK10037
220341012714	YhjQ protein; Region: YhjQ; pfam06564
220341012715	cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498
220341012716	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
220341012717	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
220341012718	DXD motif; other site
220341012719	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
220341012720	PilZ domain; Region: PilZ; pfam07238
220341012721	cellulose synthase regulator protein; Provisional; Region: PRK11114
220341012722	PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site
220341012723	endo-1,4-D-glucanase; Provisional; Region: PRK11097
220341012724	PS00812 Glycosyl hydrolases family 8 signature
220341012725	putative diguanylate cyclase; Provisional; Region: PRK13561
220341012726	Protein of unknown function (DUF3112); Region: DUF3112; pfam11309
220341012727	HAMP domain; Region: HAMP; pfam00672
220341012728	diguanylate cyclase; Region: GGDEF; smart00267
220341012729	metal binding site [ion binding]; metal-binding site
220341012730	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
220341012731	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
220341012732	PS00713 Sodium:dicarboxylate symporter family signature 1
220341012733	PS00714 Sodium:dicarboxylate symporter family signature 2
220341012734	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
220341012735	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
220341012736	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
220341012737	substrate binding site [chemical binding]; other site
220341012738	ATP binding site [chemical binding]; other site
220341012739	PS00584 pfkB family of carbohydrate kinases signature 2
220341012740	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
220341012741	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
220341012742	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
220341012743	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341012744	metabolite-proton symporter; Region: 2A0106; TIGR00883
220341012745	putative substrate translocation pore; other site
220341012746	PS00216 Sugar transport proteins signature 1
220341012747	inner membrane protein YhjD; Region: TIGR00766
220341012748	Transcriptional regulator [Transcription]; Region: LysR; COG0583
220341012749	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341012750	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
220341012751	putative effector binding pocket; other site
220341012752	putative dimerization interface [polypeptide binding]; other site
220341012753	PS00044 Bacterial regulatory proteins, lysR family signature
220341012754	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
220341012755	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
220341012756	DNA binding residues [nucleotide binding]
220341012757	dimerization interface [polypeptide binding]; other site
220341012758	PS00622 Bacterial regulatory proteins, luxR family signature
220341012759	Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772
220341012760	catalytic residue [active]
220341012761	Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626
220341012762	trehalase; Provisional; Region: treF; PRK13270
220341012763	PS00928 Trehalase signature 2
220341012764	PS00927 Trehalase signature 1
220341012765	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
220341012766	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
220341012767	DNA-binding site [nucleotide binding]; DNA binding site
220341012768	UTRA domain; Region: UTRA; pfam07702
220341012769	Gene remnant. Similar to internal fragment of Erwinia chrysanthemi L-asparaginase precursor asn SW:ASPG_ERWCH (P06608) (348 aa) fasta scores: E(): 1.9e-21, 81.2% id in 69 aa. Deletion of DNA relative to Salmonella typhimurium.
220341012770	PS00917 Asparaginase / glutaminase active site signature 2
220341012771	glutathione reductase; Validated; Region: PRK06116
220341012772	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
220341012773	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
220341012774	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
220341012775	PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site
220341012776	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
220341012777	PS00092 N-6 Adenine-specific DNA methylases signature
220341012778	PS00092 N-6 Adenine-specific DNA methylases signature
220341012779	hypothetical protein; Provisional; Region: PRK10215
220341012780	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341012781	PS00017 ATP/GTP-binding site motif A (P-loop)
220341012782	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
220341012783	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
220341012784	active site
220341012785	Zn binding site [ion binding]; other site
220341012786	PS00142 Neutral zinc metallopeptidases, zinc-binding region signature
220341012787	putative methyltransferase; Provisional; Region: PRK10742
220341012788	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
220341012789	S-adenosylmethionine binding site [chemical binding]; other site
220341012790	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
220341012791	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341012792	putative substrate translocation pore; other site
220341012793	PS01023 PTR2 family proton/oligopeptide symporters signature 2
220341012794	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
220341012795	Ligand Binding Site [chemical binding]; other site
220341012796	universal stress protein UspB; Provisional; Region: PRK04960
220341012797	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
220341012798	Predicted flavoproteins [General function prediction only]; Region: COG2081
220341012799	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
220341012800	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
220341012801	YheO-like PAS domain; Region: PAS_6; pfam08348
220341012802	HTH domain; Region: HTH_22; pfam13309
220341012803	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
220341012804	homotrimer interaction site [polypeptide binding]; other site
220341012805	putative active site [active]
220341012806	PS01094 Uncharacterized protein family UPF0076 signature
220341012807	putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350
220341012808	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
220341012809	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341012810	homodimer interface [polypeptide binding]; other site
220341012811	catalytic residue [active]
220341012812	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341012813	putative substrate translocation pore; other site
220341012814	Major Facilitator Superfamily; Region: MFS_1; pfam07690
220341012815	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
220341012816	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
220341012817	HlyD family secretion protein; Region: HlyD_3; pfam13437
220341012818	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
220341012819	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
220341012820	Walker A/P-loop; other site
220341012821	ATP binding site [chemical binding]; other site
220341012822	Q-loop/lid; other site
220341012823	ABC transporter signature motif; other site
220341012824	Walker B; other site
220341012825	D-loop; other site
220341012826	H-loop/switch region; other site
220341012827	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
220341012828	Walker A/P-loop; other site
220341012829	ATP binding site [chemical binding]; other site
220341012830	Q-loop/lid; other site
220341012831	ABC transporter signature motif; other site
220341012832	Walker B; other site
220341012833	D-loop; other site
220341012834	H-loop/switch region; other site
220341012835	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
220341012836	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
220341012837	PS00017 ATP/GTP-binding site motif A (P-loop)
220341012838	PS00211 ABC transporters family signature
220341012839	DNA repeat, similar to 4091552..4091632, 76.3% identity in 80 nt overlap
220341012840	PS00017 ATP/GTP-binding site motif A (P-loop)
220341012841	DNA repeat, similar to 4090772..4090852, 76.3% identity in 80 nt overlap
220341012842	nickel responsive regulator; Provisional; Region: PRK02967
220341012843	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
220341012844	holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351
220341012845	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
220341012846	Domain of unknown function DUF20; Region: UPF0118; cl00465
220341012847	major facilitator superfamily transporter; Provisional; Region: PRK05122
220341012848	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341012849	putative substrate translocation pore; other site
220341012850	hypothetical protein; Provisional; Region: PRK11615
220341012851	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341012852	hypothetical protein; Provisional; Region: PRK11212
220341012853	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
220341012854	CPxP  motif; other site
220341012855	PS01148 Uncharacterized protein family UPF0033 signature
220341012856	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
220341012857	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
220341012858	dimer interface [polypeptide binding]; other site
220341012859	ligand binding site [chemical binding]; other site
220341012860	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
220341012861	dimerization interface [polypeptide binding]; other site
220341012862	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
220341012863	dimer interface [polypeptide binding]; other site
220341012864	putative CheW interface [polypeptide binding]; other site
220341012865	PS00538 Bacterial chemotaxis sensory transducers signature
220341012866	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
220341012867	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
220341012868	metal-binding site [ion binding]
220341012869	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
220341012870	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
220341012871	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
220341012872	PS00154 E1-E2 ATPases phosphorylation site
220341012873	PS01047 Heavy-metal-associated domain
220341012874	Predicted membrane protein [Function unknown]; Region: COG3714
220341012875	Protein of unknown function (DUF2500); Region: DUF2500; pfam10694
220341012876	hypothetical protein; Provisional; Region: PRK10910
220341012877	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
220341012878	S-adenosylmethionine binding site [chemical binding]; other site
220341012879	PS00092 N-6 Adenine-specific DNA methylases signature
220341012880	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
220341012881	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
220341012882	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
220341012883	P loop; other site
220341012884	GTP binding site [chemical binding]; other site
220341012885	PS00017 ATP/GTP-binding site motif A (P-loop)
220341012886	PS00300 SRP54-type proteins GTP-binding domain signature
220341012887	cell division protein FtsE; Provisional; Region: PRK10908
220341012888	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
220341012889	Walker A/P-loop; other site
220341012890	ATP binding site [chemical binding]; other site
220341012891	Q-loop/lid; other site
220341012892	ABC transporter signature motif; other site
220341012893	Walker B; other site
220341012894	D-loop; other site
220341012895	H-loop/switch region; other site
220341012896	PS00017 ATP/GTP-binding site motif A (P-loop)
220341012897	PS00211 ABC transporters family signature
220341012898	putative protein insertion permease FtsX; Region: ftsX; TIGR00439
220341012899	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
220341012900	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
220341012901	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
220341012902	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
220341012903	DNA binding residues [nucleotide binding]
220341012904	PS00715 Sigma-70 factors family signature 1
220341012905	PS00716 Sigma-70 factors family signature 2
220341012906	DNA repeat, similar to 4112554..4113413, 78.3% identity in 858 nt overlap. Probably resulted from gene duplication
220341012907	DNA repeat, similar to 4113501..4113606. 75.2% identity in 105 nt overlap. Probably resulted from gene duplication
220341012908	Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568
220341012909	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
220341012910	dimerization interface [polypeptide binding]; other site
220341012911	Receptor family ligand binding region; Region: ANF_receptor; pfam01094
220341012912	ligand binding site [chemical binding]; other site
220341012913	DNA repeat, similar to 4110450..4111309, 78.3% identity in 858 nt overlap. Probably resulted from gene duplication
220341012914	region of DNA repeat, similar to 4111391..4111496. 75.2% identity in 105 nt overlap. Probably resulted from gene duplication
220341012915	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
220341012916	TM-ABC transporter signature motif; other site
220341012917	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
220341012918	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
220341012919	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
220341012920	TM-ABC transporter signature motif; other site
220341012921	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
220341012922	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
220341012923	Walker A/P-loop; other site
220341012924	ATP binding site [chemical binding]; other site
220341012925	Q-loop/lid; other site
220341012926	ABC transporter signature motif; other site
220341012927	Walker B; other site
220341012928	D-loop; other site
220341012929	H-loop/switch region; other site
220341012930	DNA repeat, similar to 4116718..4116774, 83.9% identity in 56 nt overlap
220341012931	PS00017 ATP/GTP-binding site motif A (P-loop)
220341012932	PS00211 ABC transporters family signature
220341012933	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614
220341012934	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
220341012935	Walker A/P-loop; other site
220341012936	ATP binding site [chemical binding]; other site
220341012937	Q-loop/lid; other site
220341012938	ABC transporter signature motif; other site
220341012939	Walker B; other site
220341012940	D-loop; other site
220341012941	H-loop/switch region; other site
220341012942	DNA repeat, similar to 4115949..4116005, 83.9% identity in 56 nt overlap
220341012943	PS00017 ATP/GTP-binding site motif A (P-loop)
220341012944	PS00211 ABC transporters family signature
220341012945	glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974
220341012946	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
220341012947	PS01037 Bacterial extracellular solute-binding proteins
220341012948	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
220341012949	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341012950	dimer interface [polypeptide binding]; other site
220341012951	conserved gate region; other site
220341012952	putative PBP binding loops; other site
220341012953	ABC-ATPase subunit interface; other site
220341012954	PS00402 Binding-protein-dependent transport systems inner membrane comp sign.
220341012955	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
220341012956	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341012957	dimer interface [polypeptide binding]; other site
220341012958	conserved gate region; other site
220341012959	ABC-ATPase subunit interface; other site
220341012960	PS00402 Binding-protein-dependent transport systems inner membrane comp sign.
220341012961	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
220341012962	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
220341012963	Walker A/P-loop; other site
220341012964	ATP binding site [chemical binding]; other site
220341012965	Q-loop/lid; other site
220341012966	ABC transporter signature motif; other site
220341012967	Walker B; other site
220341012968	D-loop; other site
220341012969	H-loop/switch region; other site
220341012970	TOBE domain; Region: TOBE_2; pfam08402
220341012971	PS00017 ATP/GTP-binding site motif A (P-loop)
220341012972	PS00211 ABC transporters family signature
220341012973	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
220341012974	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
220341012975	putative active site [active]
220341012976	catalytic site [active]
220341012977	putative metal binding site [ion binding]; other site
220341012978	hypothetical protein; Provisional; Region: PRK10350
220341012979	gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615
220341012980	PS00462 Gamma-glutamyltranspeptidase signature
220341012981	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
220341012982	active site
220341012983	substrate binding pocket [chemical binding]; other site
220341012984	homodimer interaction site [polypeptide binding]; other site
220341012985	PS01322 Phosphotriesterase family signature 1
220341012986	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
220341012987	Protein of unknown function, DUF606; Region: DUF606; pfam04657
220341012988	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
220341012989	PS00017 ATP/GTP-binding site motif A (P-loop)
220341012990	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
220341012991	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
220341012992	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
220341012993	substrate binding site [chemical binding]; other site
220341012994	dimer interface [polypeptide binding]; other site
220341012995	ATP binding site [chemical binding]; other site
220341012996	PS00584 pfkB family of carbohydrate kinases signature 2
220341012997	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
220341012998	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
220341012999	Coenzyme A binding pocket [chemical binding]; other site
220341013000	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
220341013001	putative oxidoreductase; Provisional; Region: PRK10206
220341013002	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
220341013003	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
220341013004	PS00017 ATP/GTP-binding site motif A (P-loop)
220341013005	Pirin-related protein [General function prediction only]; Region: COG1741
220341013006	Pirin; Region: Pirin; pfam02678
220341013007	gluconate operon transcriptional regulator; Provisional; Region: PRK14987
220341013008	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
220341013009	DNA binding site [nucleotide binding]
220341013010	domain linker motif; other site
220341013011	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
220341013012	putative ligand binding site [chemical binding]; other site
220341013013	putative dimerization interface [polypeptide binding]; other site
220341013014	PS00356 Bacterial regulatory proteins, lacI family signature
220341013015	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
220341013016	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
220341013017	ATP-binding site [chemical binding]; other site
220341013018	Gluconate-6-phosphate binding site [chemical binding]; other site
220341013019	PS00017 ATP/GTP-binding site motif A (P-loop)
220341013020	low affinity gluconate transporter; Provisional; Region: PRK10472
220341013021	GntP family permease; Region: GntP_permease; pfam02447
220341013022	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
220341013023	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118
220341013024	Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774
220341013025	PS01103 Aspartate-semialdehyde dehydrogenase signature
220341013026	glycogen branching enzyme; Provisional; Region: PRK05402
220341013027	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
220341013028	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
220341013029	active site
220341013030	catalytic site [active]
220341013031	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
220341013032	glycogen debranching enzyme; Provisional; Region: PRK03705
220341013033	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
220341013034	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
220341013035	active site
220341013036	catalytic site [active]
220341013037	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
220341013038	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
220341013039	ligand binding site; other site
220341013040	oligomer interface; other site
220341013041	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
220341013042	dimer interface [polypeptide binding]; other site
220341013043	N-terminal domain interface [polypeptide binding]; other site
220341013044	sulfate 1 binding site; other site
220341013045	PS00808 ADP-glucose pyrophosphorylase signature 1
220341013046	PS00809 ADP-glucose pyrophosphorylase signature 2
220341013047	PS00810 ADP-glucose pyrophosphorylase signature 3
220341013048	glycogen synthase; Provisional; Region: glgA; PRK00654
220341013049	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
220341013050	ADP-binding pocket [chemical binding]; other site
220341013051	homodimer interface [polypeptide binding]; other site
220341013052	glycogen phosphorylase; Provisional; Region: PRK14986
220341013053	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
220341013054	homodimer interface [polypeptide binding]; other site
220341013055	active site pocket [active]
220341013056	PS00102 Phosphorylase pyridoxal-phosphate attachment site
220341013057	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
220341013058	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
220341013059	PS00978 FAD-dependent glycerol-3-phosphate dehydrogenase signature 2
220341013060	PS00977 FAD-dependent glycerol-3-phosphate dehydrogenase signature 1
220341013061	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
220341013062	active site residue [active]
220341013063	intramembrane serine protease GlpG; Provisional; Region: PRK10907
220341013064	Protein of unknown function (DUF3582); Region: DUF3582; pfam12122
220341013065	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
220341013066	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
220341013067	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
220341013068	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
220341013069	PS00894 Bacterial regulatory proteins, deoR family signature
220341013070	transcriptional regulator MalT; Provisional; Region: PRK04841
220341013071	AAA ATPase domain; Region: AAA_16; pfam13191
220341013072	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
220341013073	DNA binding residues [nucleotide binding]
220341013074	dimerization interface [polypeptide binding]; other site
220341013075	PS00622 Bacterial regulatory proteins, luxR family signature
220341013076	maltodextrin phosphorylase; Provisional; Region: PRK14985
220341013077	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
220341013078	homodimer interface [polypeptide binding]; other site
220341013079	active site pocket [active]
220341013080	PS00102 Phosphorylase pyridoxal-phosphate attachment site
220341013081	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
220341013082	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
220341013083	high-affinity gluconate transporter; Provisional; Region: PRK14984
220341013084	GntP family permease; Region: GntP_permease; pfam02447
220341013085	Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190
220341013086	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
220341013087	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
220341013088	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
220341013089	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
220341013090	active site
220341013091	carboxylesterase BioH; Provisional; Region: PRK10349
220341013092	Putative lysophospholipase; Region: Hydrolase_4; cl19140
220341013093	hypothetical protein; Provisional; Region: PRK09956
220341013094	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
220341013095	ferrous iron transport protein FeoC; Provisional; Region: PRK15431
220341013096	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
220341013097	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
220341013098	G1 box; other site
220341013099	GTP/Mg2+ binding site [chemical binding]; other site
220341013100	Switch I region; other site
220341013101	G2 box; other site
220341013102	G3 box; other site
220341013103	Switch II region; other site
220341013104	G4 box; other site
220341013105	G5 box; other site
220341013106	Nucleoside recognition; Region: Gate; pfam07670
220341013107	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
220341013108	Nucleoside recognition; Region: Gate; pfam07670
220341013109	PS00017 ATP/GTP-binding site motif A (P-loop)
220341013110	PS00017 ATP/GTP-binding site motif A (P-loop)
220341013111	ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555
220341013112	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
220341013113	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
220341013114	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
220341013115	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
220341013116	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
220341013117	RNA binding site [nucleotide binding]; other site
220341013118	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
220341013119	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
220341013120	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
220341013121	PS00830 Prokaryotic transcription elongation factors signature 2
220341013122	PS00829 Prokaryotic transcription elongation factors signature 1
220341013123	osmolarity response regulator; Provisional; Region: ompR; PRK09468
220341013124	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
220341013125	active site
220341013126	phosphorylation site [posttranslational modification]
220341013127	intermolecular recognition site; other site
220341013128	dimerization interface [polypeptide binding]; other site
220341013129	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
220341013130	DNA binding site [nucleotide binding]
220341013131	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
220341013132	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
220341013133	dimerization interface [polypeptide binding]; other site
220341013134	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
220341013135	dimer interface [polypeptide binding]; other site
220341013136	phosphorylation site [posttranslational modification]
220341013137	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
220341013138	ATP binding site [chemical binding]; other site
220341013139	Mg2+ binding site [ion binding]; other site
220341013140	G-X-G motif; other site
220341013141	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
220341013142	active site
220341013143	substrate-binding site [chemical binding]; other site
220341013144	metal-binding site [ion binding]
220341013145	ATP binding site [chemical binding]; other site
220341013146	PS00532 Phosphoenolpyruvate carboxykinase (ATP) signature
220341013147	PS00017 ATP/GTP-binding site motif A (P-loop)
220341013148	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158
220341013149	Domain of unknown function (DUF4153); Region: DUF4153; pfam13687
220341013150	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
220341013151	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
220341013152	dimerization interface [polypeptide binding]; other site
220341013153	domain crossover interface; other site
220341013154	redox-dependent activation switch; other site
220341013155	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
220341013156	RNA binding surface [nucleotide binding]; other site
220341013157	GMP/IMP nucleotidase; Provisional; Region: PRK14988
220341013158	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
220341013159	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
220341013160	motif II; other site
220341013161	Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095
220341013162	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
220341013163	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
220341013164	ADP-ribose binding site [chemical binding]; other site
220341013165	dimer interface [polypeptide binding]; other site
220341013166	active site
220341013167	nudix motif; other site
220341013168	metal binding site [ion binding]; metal-binding site
220341013169	PS00893 mutT domain signature
220341013170	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
220341013171	Transglycosylase; Region: Transgly; pfam00912
220341013172	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
220341013173	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
220341013174	Protein of unknown function (DUF2531); Region: DUF2531; pfam10748
220341013175	outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560
220341013176	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
220341013177	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
220341013178	PS00875 Bacterial type II secretion system protein D signature
220341013179	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
220341013180	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
220341013181	ADP binding site [chemical binding]; other site
220341013182	magnesium binding site [ion binding]; other site
220341013183	putative shikimate binding site; other site
220341013184	PS01128 Shikimate kinase signature
220341013185	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
220341013186	active site
220341013187	dimer interface [polypeptide binding]; other site
220341013188	metal binding site [ion binding]; metal-binding site
220341013189	cell division protein DamX; Validated; Region: PRK10905
220341013190	Sporulation related domain; Region: SPOR; pfam05036
220341013191	DNA adenine methylase; Provisional; Region: PRK10904
220341013192	PS00092 N-6 Adenine-specific DNA methylases signature
220341013193	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
220341013194	substrate binding site [chemical binding]; other site
220341013195	hexamer interface [polypeptide binding]; other site
220341013196	metal binding site [ion binding]; metal-binding site
220341013197	PS01085 Ribulose-phosphate 3-epimerase family signature 1
220341013198	PS01086 Ribulose-phosphate 3-epimerase family signature 2
220341013199	phosphoglycolate phosphatase; Provisional; Region: PRK13222
220341013200	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
220341013201	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
220341013202	motif II; other site
220341013203	tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927
220341013204	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
220341013205	active site
220341013206	HIGH motif; other site
220341013207	dimer interface [polypeptide binding]; other site
220341013208	KMSKS motif; other site
220341013209	PS00178 Aminoacyl-transfer RNA synthetases class-I signature
220341013210	Protein of unknown function (DUF4223); Region: DUF4223; pfam13978
220341013211	siroheme synthase; Provisional; Region: cysG; PRK10637
220341013212	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
220341013213	Sirohaem biosynthesis protein central; Region: Sirohm_synth_M; pfam14824
220341013214	Sirohaem synthase dimerization region; Region: CysG_dimeriser; pfam10414
220341013215	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
220341013216	active site
220341013217	SAM binding site [chemical binding]; other site
220341013218	homodimer interface [polypeptide binding]; other site
220341013219	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341013220	PS00840 Uroporphyrin-III C-methyltransferase signature 2
220341013221	PS00839 Uroporphyrin-III C-methyltransferase signature 1
220341013222	nitrite transporter NirC; Provisional; Region: PRK11562
220341013223	PS01006 Formate and nitrite transporters signature 2
220341013224	PS01005 Formate and nitrite transporters signature 1
220341013225	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
220341013226	nitrite reductase subunit NirD; Provisional; Region: PRK14989
220341013227	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
220341013228	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
220341013229	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
220341013230	PS00365 Nitrite and sulfite reductases iron-sulfur/siroheme-binding site
220341013231	putative transporter; Provisional; Region: PRK03699
220341013232	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341013233	putative substrate translocation pore; other site
220341013234	PS00217 Sugar transport proteins signature 2
220341013235	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
220341013236	substrate binding site [chemical binding]; other site
220341013237	PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature
220341013238	hypothetical protein; Provisional; Region: PRK10204
220341013239	cell filamentation protein Fic; Provisional; Region: PRK10347
220341013240	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
220341013241	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
220341013242	glutamine binding [chemical binding]; other site
220341013243	catalytic triad [active]
220341013244	PS00442 Glutamine amidotransferases class-I active site
220341013245	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
220341013246	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
220341013247	inhibitor-cofactor binding pocket; inhibition site
220341013248	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341013249	catalytic residue [active]
220341013250	PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site
220341013251	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
220341013252	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
220341013253	ligand binding site [chemical binding]; other site
220341013254	flexible hinge region; other site
220341013255	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
220341013256	putative switch regulator; other site
220341013257	non-specific DNA interactions [nucleotide binding]; other site
220341013258	DNA binding site [nucleotide binding]
220341013259	sequence specific DNA binding site [nucleotide binding]; other site
220341013260	putative cAMP binding site [chemical binding]; other site
220341013261	PS00042 Bacterial regulatory proteins, crp family signature
220341013262	PS00889 Cyclic nucleotide-binding domain signature 2
220341013263	PS00888 Cyclic nucleotide-binding domain signature 1
220341013264	hypothetical protein; Provisional; Region: PRK10738
220341013265	phosphoribulokinase; Provisional; Region: PRK15453
220341013266	active site
220341013267	PS00567 Phosphoribulokinase signature
220341013268	hypothetical protein; Provisional; Region: PRK04966
220341013269	putative monooxygenase; Provisional; Region: PRK11118
220341013270	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
220341013271	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
220341013272	ABC transporter; Region: ABC_tran_2; pfam12848
220341013273	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
220341013274	PS00211 ABC transporters family signature
220341013275	PS00017 ATP/GTP-binding site motif A (P-loop)
220341013276	PS00211 ABC transporters family signature
220341013277	PS00017 ATP/GTP-binding site motif A (P-loop)
220341013278	glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930
220341013279	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
220341013280	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
220341013281	TrkA-N domain; Region: TrkA_N; pfam02254
220341013282	Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529
220341013283	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737
220341013284	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
220341013285	PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1
220341013286	PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2
220341013287	phi X174 lysis protein; Provisional; Region: PRK02793
220341013288	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902
220341013289	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
220341013290	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
220341013291	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
220341013292	YheO-like PAS domain; Region: PAS_6; pfam08348
220341013293	HTH domain; Region: HTH_22; pfam13309
220341013294	sulfur transfer complex subunit TusD; Validated; Region: PRK00207
220341013295	sulfur relay protein TusC; Validated; Region: PRK00211
220341013296	sulfur transfer complex subunit TusB; Provisional; Region: PRK13510
220341013297	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
220341013298	S17 interaction site [polypeptide binding]; other site
220341013299	S8 interaction site; other site
220341013300	16S rRNA interaction site [nucleotide binding]; other site
220341013301	streptomycin interaction site [chemical binding]; other site
220341013302	23S rRNA interaction site [nucleotide binding]; other site
220341013303	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
220341013304	PS00055 Ribosomal protein S12 signature
220341013305	30S ribosomal protein S7; Validated; Region: PRK05302
220341013306	PS00052 Ribosomal protein S7 signature
220341013307	elongation factor G; Reviewed; Region: PRK00007
220341013308	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
220341013309	G1 box; other site
220341013310	putative GEF interaction site [polypeptide binding]; other site
220341013311	GTP/Mg2+ binding site [chemical binding]; other site
220341013312	Switch I region; other site
220341013313	G2 box; other site
220341013314	G3 box; other site
220341013315	Switch II region; other site
220341013316	G4 box; other site
220341013317	G5 box; other site
220341013318	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
220341013319	Elongation Factor G, domain II; Region: EFG_II; pfam14492
220341013320	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
220341013321	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
220341013322	PS00017 ATP/GTP-binding site motif A (P-loop)
220341013323	PS00301 GTP-binding elongation factors signature
220341013324	elongation factor Tu; Reviewed; Region: PRK00049
220341013325	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
220341013326	G1 box; other site
220341013327	GEF interaction site [polypeptide binding]; other site
220341013328	GTP/Mg2+ binding site [chemical binding]; other site
220341013329	Switch I region; other site
220341013330	G2 box; other site
220341013331	G3 box; other site
220341013332	Switch II region; other site
220341013333	G4 box; other site
220341013334	G5 box; other site
220341013335	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
220341013336	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
220341013337	Antibiotic Binding Site [chemical binding]; other site
220341013338	PS00017 ATP/GTP-binding site motif A (P-loop)
220341013339	PS00301 GTP-binding elongation factors signature
220341013340	bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509
220341013341	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
220341013342	Ferritin-like domain; Region: Ferritin; pfam00210
220341013343	heme binding site [chemical binding]; other site
220341013344	ferroxidase pore; other site
220341013345	ferroxidase diiron center [ion binding]; other site
220341013346	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
220341013347	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
220341013348	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
220341013349	PS00361 Ribosomal protein S10 signature
220341013350	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
220341013351	PS00474 Ribosomal protein L3 signature
220341013352	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
220341013353	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
220341013354	PS00050 Ribosomal protein L23 signature
220341013355	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
220341013356	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
220341013357	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
220341013358	PS00467 Ribosomal protein L2 signature
220341013359	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
220341013360	PS00323 Ribosomal protein S19 signature
220341013361	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
220341013362	protein-rRNA interface [nucleotide binding]; other site
220341013363	putative translocon binding site; other site
220341013364	PS00464 Ribosomal protein L22 signature
220341013365	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
220341013366	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
220341013367	G-X-X-G motif; other site
220341013368	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
220341013369	PS00548 Ribosomal protein S3 signature
220341013370	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
220341013371	23S rRNA interface [nucleotide binding]; other site
220341013372	5S rRNA interface [nucleotide binding]; other site
220341013373	putative antibiotic binding site [chemical binding]; other site
220341013374	L25 interface [polypeptide binding]; other site
220341013375	L27 interface [polypeptide binding]; other site
220341013376	PS00586 Ribosomal protein L16 signature 1
220341013377	PS00701 Ribosomal protein L16 signature 2
220341013378	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
220341013379	23S rRNA interface [nucleotide binding]; other site
220341013380	putative translocon interaction site; other site
220341013381	signal recognition particle (SRP54) interaction site; other site
220341013382	L23 interface [polypeptide binding]; other site
220341013383	trigger factor interaction site; other site
220341013384	PS00579 Ribosomal protein L29 signature
220341013385	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
220341013386	PS00056 Ribosomal protein S17 signature
220341013387	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
220341013388	PS00049 Ribosomal protein L14 signature
220341013389	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
220341013390	RNA binding site [nucleotide binding]; other site
220341013391	PS01108 Ribosomal protein L24 signature
220341013392	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
220341013393	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
220341013394	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
220341013395	PS00358 Ribosomal protein L5 signature
220341013396	PS01156 TonB-dependent receptor proteins signature 2
220341013397	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
220341013398	PS00527 Ribosomal protein S14 signature
220341013399	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
220341013400	PS00053 Ribosomal protein S8 signature
220341013401	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
220341013402	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
220341013403	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
220341013404	PS00525 Ribosomal protein L6 signature 1
220341013405	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
220341013406	23S rRNA interface [nucleotide binding]; other site
220341013407	5S rRNA interface [nucleotide binding]; other site
220341013408	L27 interface [polypeptide binding]; other site
220341013409	L5 interface [polypeptide binding]; other site
220341013410	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
220341013411	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
220341013412	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
220341013413	PS00585 Ribosomal protein S5 signature
220341013414	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
220341013415	23S rRNA binding site [nucleotide binding]; other site
220341013416	PS00634 Ribosomal protein L30 signature
220341013417	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
220341013418	PS00475 Ribosomal protein L15 signature
220341013419	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
220341013420	SecY translocase; Region: SecY; pfam00344
220341013421	PS00755 Protein secY signature 1
220341013422	PS00756 Protein secY signature 2
220341013423	PS00095 C-5 cytosine-specific DNA methylases C-terminal signature
220341013424	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
220341013425	PS00828 Ribosomal protein L36 signature
220341013426	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
220341013427	PS00061 Short-chain dehydrogenases/reductases family signature
220341013428	PS00646 Ribosomal protein S13 signature
220341013429	30S ribosomal protein S11; Validated; Region: PRK05309
220341013430	PS00054 Ribosomal protein S11 signature
220341013431	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
220341013432	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
220341013433	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
220341013434	RNA binding surface [nucleotide binding]; other site
220341013435	PS00632 Ribosomal protein S4 signature
220341013436	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
220341013437	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
220341013438	alphaNTD homodimer interface [polypeptide binding]; other site
220341013439	alphaNTD - beta interaction site [polypeptide binding]; other site
220341013440	alphaNTD - beta' interaction site [polypeptide binding]; other site
220341013441	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
220341013442	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
220341013443	PS01167 Ribosomal protein L17 signature
220341013444	hypothetical protein; Provisional; Region: PRK10203
220341013445	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
220341013446	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
220341013447	DNA binding residues [nucleotide binding]
220341013448	dimer interface [polypeptide binding]; other site
220341013449	metal binding site [ion binding]; metal-binding site
220341013450	PS00552 Bacterial regulatory proteins, merR family signature
220341013451	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
220341013452	PS01327 Large-conductance mechanosensitive channels mscL family signature
220341013453	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
220341013454	TrkA-N domain; Region: TrkA_N; pfam02254
220341013455	TrkA-C domain; Region: TrkA_C; pfam02080
220341013456	TrkA-N domain; Region: TrkA_N; pfam02254
220341013457	TrkA-C domain; Region: TrkA_C; pfam02080
220341013458	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
220341013459	putative RNA binding site [nucleotide binding]; other site
220341013460	16S rRNA methyltransferase B; Provisional; Region: PRK10901
220341013461	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
220341013462	S-adenosylmethionine binding site [chemical binding]; other site
220341013463	PS01153 NOL1/NOP2/sun family signature
220341013464	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
220341013465	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
220341013466	putative active site [active]
220341013467	substrate binding site [chemical binding]; other site
220341013468	putative cosubstrate binding site; other site
220341013469	catalytic site [active]
220341013470	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
220341013471	substrate binding site [chemical binding]; other site
220341013472	PS00373 Phosphoribosylglycinamide formyltransferase active site
220341013473	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
220341013474	active site
220341013475	catalytic residues [active]
220341013476	metal binding site [ion binding]; metal-binding site
220341013477	hypothetical protein; Provisional; Region: PRK10736
220341013478	DNA protecting protein DprA; Region: dprA; TIGR00732
220341013479	PS00017 ATP/GTP-binding site motif A (P-loop)
220341013480	hypothetical protein; Validated; Region: PRK03430
220341013481	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
220341013482	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
220341013483	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
220341013484	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
220341013485	tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634
220341013486	PS01147 SUA5/yciO/yrdC family signature
220341013487	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
220341013488	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
220341013489	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
220341013490	shikimate binding site; other site
220341013491	NAD(P) binding site [chemical binding]; other site
220341013492	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
220341013493	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
220341013494	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
220341013495	trimer interface [polypeptide binding]; other site
220341013496	putative metal binding site [ion binding]; other site
220341013497	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
220341013498	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
220341013499	Coenzyme A binding pocket [chemical binding]; other site
220341013500	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
220341013501	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
220341013502	proposed active site lysine [active]
220341013503	conserved cys residue [active]
220341013504	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
220341013505	active site
220341013506	PS00510 Malate synthase signature
220341013507	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
220341013508	tetramer interface [polypeptide binding]; other site
220341013509	active site
220341013510	Mg2+/Mn2+ binding site [ion binding]; other site
220341013511	PS00161 Isocitrate lyase signature
220341013512	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
220341013513	transcriptional repressor IclR; Provisional; Region: PRK11569
220341013514	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
220341013515	Bacterial transcriptional regulator; Region: IclR; pfam01614
220341013516	PS01051 Bacterial regulatory proteins, iclR family signature
220341013517	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
220341013518	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
220341013519	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
220341013520	substrate binding pocket [chemical binding]; other site
220341013521	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
220341013522	B12 binding site [chemical binding]; other site
220341013523	cobalt ligand [ion binding]; other site
220341013524	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
220341013525	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
220341013526	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
220341013527	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
220341013528	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
220341013529	active site pocket [active]
220341013530	oxyanion hole [active]
220341013531	catalytic triad [active]
220341013532	active site nucleophile [active]
220341013533	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122
220341013534	23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475
220341013535	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
220341013536	RNA binding surface [nucleotide binding]; other site
220341013537	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
220341013538	probable active site [active]
220341013539	PS01149 Rsu family of pseudouridine synthase signature
220341013540	hypothetical protein; Provisional; Region: PRK10515
220341013541	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
220341013542	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
220341013543	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
220341013544	PS00894 Bacterial regulatory proteins, deoR family signature
220341013545	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
220341013546	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
220341013547	active site
220341013548	motif I; other site
220341013549	motif II; other site
220341013550	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
220341013551	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
220341013552	phosphate binding site [ion binding]; other site
220341013553	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
220341013554	aspartate kinase III; Validated; Region: PRK09084
220341013555	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
220341013556	nucleotide binding site [chemical binding]; other site
220341013557	substrate binding site [chemical binding]; other site
220341013558	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
220341013559	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917
220341013560	dimer interface [polypeptide binding]; other site
220341013561	PS00324 Aspartokinase signature
220341013562	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
220341013563	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
220341013564	active site
220341013565	dimer interface [polypeptide binding]; other site
220341013566	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
220341013567	dimer interface [polypeptide binding]; other site
220341013568	active site
220341013569	PS00765 Phosphoglucose isomerase signature 1
220341013570	PS00174 Phosphoglucose isomerase signature 2
220341013571	Exopolysaccharide production protein YjbE; Region: YjbE; pfam11106
220341013572	Group 4 capsule polysaccharide formation lipoprotein gfcB; Region: Cap_synth_GfcB; pfam11102
220341013573	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341013574	Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251
220341013575	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
220341013576	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341013577	Predicted membrane protein [Function unknown]; Region: COG3223
220341013578	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
220341013579	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341013580	dimer interface [polypeptide binding]; other site
220341013581	conserved gate region; other site
220341013582	putative PBP binding loops; other site
220341013583	ABC-ATPase subunit interface; other site
220341013584	PS00402 Binding-protein-dependent transport systems inner membrane comp sign.
220341013585	maltose transporter membrane protein; Provisional; Region: malF; PRK10999
220341013586	Maltose transport system permease protein MalF P2 domain; Region: MalF_P2; pfam14785
220341013587	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
220341013588	dimer interface [polypeptide binding]; other site
220341013589	conserved gate region; other site
220341013590	putative PBP binding loops; other site
220341013591	ABC-ATPase subunit interface; other site
220341013592	PS00402 Binding-protein-dependent transport systems inner membrane comp sign.
220341013593	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
220341013594	maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474
220341013595	PS01037 Bacterial extracellular solute-binding proteins
220341013596	maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000
220341013597	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
220341013598	Walker A/P-loop; other site
220341013599	ATP binding site [chemical binding]; other site
220341013600	Q-loop/lid; other site
220341013601	ABC transporter signature motif; other site
220341013602	Walker B; other site
220341013603	D-loop; other site
220341013604	H-loop/switch region; other site
220341013605	TOBE domain; Region: TOBE_2; pfam08402
220341013606	PS00017 ATP/GTP-binding site motif A (P-loop)
220341013607	PS00211 ABC transporters family signature
220341013608	maltoporin; Provisional; Region: lamB; PRK09360
220341013609	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
220341013610	trimer interface; other site
220341013611	sugar binding site [chemical binding]; other site
220341013612	maltose regulon periplasmic protein; Provisional; Region: PRK10564
220341013613	chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655
220341013614	4-Hydroxybenzoate polyprenyltransferase; Region: PT_UbiA_COQ2; cd13959
220341013615	putative active site [active]
220341013616	PS00943 UbiA prenyltransferase family signature
220341013617	Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937
220341013618	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
220341013619	putative acyl-acceptor binding pocket; other site
220341013620	Integral membrane diacylglycerol kinase; Region: DAGK_IM; cd14264
220341013621	putative active site [active]
220341013622	trimer interface [polypeptide binding]; other site
220341013623	putative active site [active]
220341013624	Zn binding site [ion binding]; other site
220341013625	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341013626	PS01069 Prokaryotic diacylglycerol kinase signature
220341013627	LexA repressor; Validated; Region: PRK00215
220341013628	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
220341013629	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
220341013630	Catalytic site [active]
220341013631	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
220341013632	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
220341013633	hypothetical protein; Provisional; Region: PRK10428
220341013634	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
220341013635	metal binding site 2 [ion binding]; metal-binding site
220341013636	putative DNA binding helix; other site
220341013637	metal binding site 1 [ion binding]; metal-binding site
220341013638	dimer interface [polypeptide binding]; other site
220341013639	structural Zn2+ binding site [ion binding]; other site
220341013640	F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729
220341013641	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
220341013642	Dihydrouridine synthase (Dus); Region: Dus; pfam01207
220341013643	FMN binding site [chemical binding]; other site
220341013644	active site
220341013645	catalytic residues [active]
220341013646	substrate binding site [chemical binding]; other site
220341013647	phage shock protein G; Reviewed; Region: pspG; PRK09459
220341013648	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
220341013649	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
220341013650	NADP binding site [chemical binding]; other site
220341013651	dimer interface [polypeptide binding]; other site
220341013652	PS01162 Quinone oxidoreductase / zeta-crystallin signature
220341013653	replicative DNA helicase; Provisional; Region: PRK08006
220341013654	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
220341013655	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
220341013656	Walker A motif; other site
220341013657	ATP binding site [chemical binding]; other site
220341013658	Walker B motif; other site
220341013659	DNA binding loops [nucleotide binding]
220341013660	PS00017 ATP/GTP-binding site motif A (P-loop)
220341013661	alanine racemase; Reviewed; Region: alr; PRK00053
220341013662	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
220341013663	active site
220341013664	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
220341013665	substrate binding site [chemical binding]; other site
220341013666	catalytic residues [active]
220341013667	dimer interface [polypeptide binding]; other site
220341013668	PS00395 Alanine racemase pyridoxal-phosphate attachment site
220341013669	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
220341013670	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
220341013671	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341013672	homodimer interface [polypeptide binding]; other site
220341013673	catalytic residue [active]
220341013674	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
220341013675	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
220341013676	active site
220341013677	motif I; other site
220341013678	motif II; other site
220341013679	Uncharacterized conserved protein [Function unknown]; Region: COG0432
220341013680	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
220341013681	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341013682	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
220341013683	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
220341013684	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
220341013685	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
220341013686	PS00211 ABC transporters family signature
220341013687	PS00017 ATP/GTP-binding site motif A (P-loop)
220341013688	PS00211 ABC transporters family signature
220341013689	PS00017 ATP/GTP-binding site motif A (P-loop)
220341013690	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
220341013691	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
220341013692	dimer interface [polypeptide binding]; other site
220341013693	ssDNA binding site [nucleotide binding]; other site
220341013694	tetramer (dimer of dimers) interface [polypeptide binding]; other site
220341013695	putative single-stranded DNA-binding protein; Region: PHA01740
220341013696	PS00735 Single-strand binding protein family signature 1
220341013697	PS00736 Single-strand binding protein family signature 2
220341013698	Salmonella Pathogenicity Island 4
220341013699	hypothetical protein; Validated; Region: PRK09039
220341013700	Zinc finger-containing protein; Region: zf-C4H2; pfam10146
220341013701	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
220341013702	Outer membrane efflux protein; Region: OEP; pfam02321
220341013703	Outer membrane efflux protein; Region: OEP; pfam02321
220341013704	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
220341013705	Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169
220341013706	HlyD family secretion protein; Region: HlyD_3; pfam13437
220341013707	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
220341013708	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341013709	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341013710	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341013711	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
220341013712	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341013713	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341013714	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341013715	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
220341013716	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
220341013717	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341013718	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
220341013719	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
220341013720	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341013721	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
220341013722	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341013723	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
220341013724	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
220341013725	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341013726	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
220341013727	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341013728	Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750
220341013729	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
220341013730	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
220341013731	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341013732	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
220341013733	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341013734	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
220341013735	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
220341013736	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341013737	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341013738	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341013739	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
220341013740	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341013741	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341013742	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341013743	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341013744	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
220341013745	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341013746	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341013747	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
220341013748	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341013749	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341013750	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
220341013751	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341013752	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341013753	Bacterial Ig-like domain (group 3); Region: Big_3_2; pfam12245
220341013754	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341013755	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341013756	Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750
220341013757	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341013758	Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750
220341013759	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341013760	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
220341013761	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341013762	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341013763	PS00017 ATP/GTP-binding site motif A (P-loop)
220341013764	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
220341013765	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
220341013766	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
220341013767	Walker A/P-loop; other site
220341013768	ATP binding site [chemical binding]; other site
220341013769	Q-loop/lid; other site
220341013770	ABC transporter signature motif; other site
220341013771	Walker B; other site
220341013772	D-loop; other site
220341013773	H-loop/switch region; other site
220341013774	PS00017 ATP/GTP-binding site motif A (P-loop)
220341013775	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
220341013776	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
220341013777	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
220341013778	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
220341013779	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341013780	PS00041 Bacterial regulatory proteins, araC family signature
220341013781	redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002
220341013782	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
220341013783	DNA binding residues [nucleotide binding]
220341013784	dimer interface [polypeptide binding]; other site
220341013785	[2Fe-2S] cluster binding site [ion binding]; other site
220341013786	PS00552 Bacterial regulatory proteins, merR family signature
220341013787	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
220341013788	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
220341013789	putative C-terminal domain interface [polypeptide binding]; other site
220341013790	putative GSH binding site (G-site) [chemical binding]; other site
220341013791	putative dimer interface [polypeptide binding]; other site
220341013792	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
220341013793	putative N-terminal domain interface [polypeptide binding]; other site
220341013794	putative dimer interface [polypeptide binding]; other site
220341013795	putative substrate binding pocket (H-site) [chemical binding]; other site
220341013796	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
220341013797	Sulfate transporter family; Region: Sulfate_transp; cl19250
220341013798	PS00017 ATP/GTP-binding site motif A (P-loop)
220341013799	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
220341013800	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
220341013801	Transcriptional regulator [Transcription]; Region: LysR; COG0583
220341013802	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341013803	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
220341013804	putative dimerization interface [polypeptide binding]; other site
220341013805	PS00044 Bacterial regulatory proteins, lysR family signature
220341013806	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
220341013807	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
220341013808	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
220341013809	Na binding site [ion binding]; other site
220341013810	PS00457 Sodium:solute symporter family signature 2
220341013811	PS00456 Sodium:solute symporter family signature 1
220341013812	Predicted membrane protein [Function unknown]; Region: COG3162
220341013813	acetyl-CoA synthetase; Provisional; Region: PRK00174
220341013814	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
220341013815	active site
220341013816	CoA binding site [chemical binding]; other site
220341013817	acyl-activating enzyme (AAE) consensus motif; other site
220341013818	AMP binding site [chemical binding]; other site
220341013819	acetate binding site [chemical binding]; other site
220341013820	PS00455 Putative AMP-binding domain signature
220341013821	cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125
220341013822	PS00190 Cytochrome c family heme-binding site signature
220341013823	PS00190 Cytochrome c family heme-binding site signature
220341013824	PS00190 Cytochrome c family heme-binding site signature
220341013825	PS00190 Cytochrome c family heme-binding site signature
220341013826	cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659
220341013827	Cytochrome c3; Region: Cytochrom_c3_2; pfam14537
220341013828	PS00190 Cytochrome c family heme-binding site signature
220341013829	PS00190 Cytochrome c family heme-binding site signature
220341013830	PS00190 Cytochrome c family heme-binding site signature
220341013831	PS00190 Cytochrome c family heme-binding site signature
220341013832	PS00190 Cytochrome c family heme-binding site signature
220341013833	cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149
220341013834	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
220341013835	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341013836	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
220341013837	heme lyase subunit NrfE; Provisional; Region: PRK10369
220341013838	PS00402 Binding-protein-dependent transport systems inner membrane comp sign.
220341013839	formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144
220341013840	formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370
220341013841	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
220341013842	binding surface
220341013843	TPR motif; other site
220341013844	glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283
220341013845	PS00713 Sodium:dicarboxylate symporter family signature 1
220341013846	PS00714 Sodium:dicarboxylate symporter family signature 2
220341013847	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
220341013848	Sel1-like repeats; Region: SEL1; smart00671
220341013849	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
220341013850	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
220341013851	[4Fe-4S] binding site [ion binding]; other site
220341013852	molybdopterin cofactor binding site; other site
220341013853	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
220341013854	molybdopterin cofactor binding site; other site
220341013855	PS00932 Prokaryotic molybdopterin oxidoreductases signature 3
220341013856	PS00490 Prokaryotic molybdopterin oxidoreductases signature 2
220341013857	PS00017 ATP/GTP-binding site motif A (P-loop)
220341013858	PS00551 Prokaryotic molybdopterin oxidoreductases signature 1
220341013859	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
220341013860	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
220341013861	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
220341013862	Coenzyme A binding pocket [chemical binding]; other site
220341013863	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
220341013864	dimer interface [polypeptide binding]; other site
220341013865	hypothetical protein; Provisional; Region: PRK10220
220341013866	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
220341013867	PhnA protein; Region: PhnA; pfam03831
220341013868	proline/glycine betaine transporter; Provisional; Region: PRK10642
220341013869	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341013870	putative substrate translocation pore; other site
220341013871	Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946
220341013872	PS00216 Sugar transport proteins signature 1
220341013873	sensor protein BasS/PmrB; Provisional; Region: PRK10755
220341013874	HAMP domain; Region: HAMP; pfam00672
220341013875	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
220341013876	dimer interface [polypeptide binding]; other site
220341013877	phosphorylation site [posttranslational modification]
220341013878	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
220341013879	ATP binding site [chemical binding]; other site
220341013880	Mg2+ binding site [ion binding]; other site
220341013881	G-X-G motif; other site
220341013882	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
220341013883	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
220341013884	active site
220341013885	phosphorylation site [posttranslational modification]
220341013886	intermolecular recognition site; other site
220341013887	dimerization interface [polypeptide binding]; other site
220341013888	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
220341013889	DNA binding site [nucleotide binding]
220341013890	putative metal dependent hydrolase; Provisional; Region: PRK11598
220341013891	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
220341013892	Sulfatase; Region: Sulfatase; pfam00884
220341013893	arginine:agmatin antiporter; Provisional; Region: PRK10644
220341013894	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
220341013895	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341013896	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
220341013897	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341013898	PS00041 Bacterial regulatory proteins, araC family signature
220341013899	arginine decarboxylase; Provisional; Region: PRK15029
220341013900	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
220341013901	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
220341013902	homodimer interface [polypeptide binding]; other site
220341013903	pyridoxal 5'-phosphate binding site [chemical binding]; other site
220341013904	catalytic residue [active]
220341013905	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
220341013906	PS00703 Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
220341013907	DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371
220341013908	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341013909	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341013910	PS00041 Bacterial regulatory proteins, araC family signature
220341013911	alpha-galactosidase; Provisional; Region: PRK15076
220341013912	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
220341013913	NAD binding site [chemical binding]; other site
220341013914	sugar binding site [chemical binding]; other site
220341013915	divalent metal binding site [ion binding]; other site
220341013916	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
220341013917	dimer interface [polypeptide binding]; other site
220341013918	PS01324 Glycosyl hydrolases family 4 signature
220341013919	melibiose:sodium symporter; Provisional; Region: PRK10429
220341013920	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
220341013921	PS00872 Sodium:galactoside symporter family signature
220341013922	fumarate hydratase; Provisional; Region: PRK15389
220341013923	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951
220341013924	Fumarase C-terminus; Region: Fumerase_C; pfam05683
220341013925	PS00163 Fumarate lyases signature
220341013926	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489
220341013927	DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430
220341013928	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
220341013929	active site
220341013930	phosphorylation site [posttranslational modification]
220341013931	intermolecular recognition site; other site
220341013932	dimerization interface [polypeptide binding]; other site
220341013933	sensory histidine kinase DcuS; Provisional; Region: PRK11086
220341013934	Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827
220341013935	PAS domain; Region: PAS; smart00091
220341013936	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
220341013937	Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689
220341013938	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
220341013939	ATP binding site [chemical binding]; other site
220341013940	Mg2+ binding site [ion binding]; other site
220341013941	G-X-G motif; other site
220341013942	This CDS appears to be a pseudogene which is highly similar to several anaerobic dimethyl sulfoxide reductases (chain A) e.g. Escherichia coli SW:DMSA_ECOLI (P18775) (814 aa) fasta scores: E(): 0, 50.8% id in 790 aa. This CDS contains a frameshift mutation after codon 352 and a stop codon following codon 622. The sequence has been checked and is believed to be correct
220341013943	PS00551 Prokaryotic molybdopterin oxidoreductases signature 1
220341013944	PS00490 Prokaryotic molybdopterin oxidoreductases signature 2
220341013945	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341013946	DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302
220341013947	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
220341013948	Domain of unknown function (DUF1996); Region: DUF1996; pfam09362
220341013949	SdiA-regulated; Region: SdiA-regulated; cd09971
220341013950	putative active site [active]
220341013951	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
220341013952	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
220341013953	DNA binding residues [nucleotide binding]
220341013954	dimerization interface [polypeptide binding]; other site
220341013955	AraC family transcriptional regulator; Provisional; Region: PRK15186
220341013956	Protein of unknown function (DUF4238); Region: DUF4238; pfam14022
220341013957	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341013958	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341013959	PS00041 Bacterial regulatory proteins, araC family signature
220341013960	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
220341013961	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
220341013962	Coenzyme A binding pocket [chemical binding]; other site
220341013963	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
220341013964	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
220341013965	active site
220341013966	PS00018 EF-hand calcium-binding domain
220341013967	PS01157 Class A bacterial acid phosphatases signature
220341013968	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
220341013969	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
220341013970	P-loop; other site
220341013971	Magnesium ion binding site [ion binding]; other site
220341013972	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
220341013973	replicative DNA helicase; Region: DnaB; TIGR00665
220341013974	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
220341013975	Walker A motif; other site
220341013976	ATP binding site [chemical binding]; other site
220341013977	Walker B motif; other site
220341013978	DNA binding loops [nucleotide binding]
220341013979	PS00017 ATP/GTP-binding site motif A (P-loop)
220341013980	integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764
220341013981	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
220341013982	Protein of unknown function (DUF2857); Region: DUF2857; pfam11198
220341013983	Helix-turn-helix domain; Region: HTH_36; pfam13730
220341013984	Low G+C region containing repeat region with 10xTGGT(A/-)(T/C)AAAAA(A/G)T.
220341013985	integrating conjugative element protein, PFL_4669 family; Region: ICE_PFL4669; TIGR03761
220341013986	DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056
220341013987	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
220341013988	active site
220341013989	putative interdomain interaction site [polypeptide binding]; other site
220341013990	putative metal-binding site [ion binding]; other site
220341013991	putative nucleotide binding site [chemical binding]; other site
220341013992	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
220341013993	domain I; other site
220341013994	DNA binding groove [nucleotide binding]
220341013995	phosphate binding site [ion binding]; other site
220341013996	domain II; other site
220341013997	domain III; other site
220341013998	nucleotide binding site [chemical binding]; other site
220341013999	catalytic site [active]
220341014000	domain IV; other site
220341014001	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
220341014002	Protein of unknown function (DUF3577); Region: DUF3577; pfam12101
220341014003	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
220341014004	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
220341014005	dimer interface [polypeptide binding]; other site
220341014006	ssDNA binding site [nucleotide binding]; other site
220341014007	tetramer (dimer of dimers) interface [polypeptide binding]; other site
220341014008	putative single-stranded DNA-binding protein; Region: PHA01740
220341014009	PS00735 Single-strand binding protein family signature 1
220341014010	PS00736 Single-strand binding protein family signature 2
220341014011	conjugative transfer region protein, TIGR03748 family; Region: conj_PilL
220341014012	Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671
220341014013	PilM; Region: PilM; pfam07419
220341014014	Pilin accessory protein (PilO); Region: PAP_PilO; pfam06864
220341014015	type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021
220341014016	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
220341014017	Walker A motif; other site
220341014018	ATP binding site [chemical binding]; other site
220341014019	Walker B motif; other site
220341014020	PS00017 ATP/GTP-binding site motif A (P-loop)
220341014021	PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site
220341014022	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
220341014023	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
220341014024	PilS N terminal; Region: PilS; pfam08805
220341014025	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
220341014026	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
220341014027	N-acetyl-D-glucosamine binding site [chemical binding]; other site
220341014028	catalytic residue [active]
220341014029	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
220341014030	Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917
220341014031	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
220341014032	Rci recombinase, C-terminal catalytic domain.  Rci enzymes are found in IncI1 incompatibility group plasmids such as R64.  These recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain...; Region: INT_Rci; cd00796
220341014033	catalytic residues [active]
220341014034	Int/Topo IB signature motif; other site
220341014035	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
220341014036	integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759
220341014037	conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754
220341014038	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
220341014039	PS00017 ATP/GTP-binding site motif A (P-loop)
220341014040	integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747
220341014041	Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686
220341014042	Protein of unknown function (DUF3262); Region: DUF3262; pfam11660
220341014043	integrating conjugative element membrane protein, PFL_4702 family; Region: conj_TIGR03745
220341014044	integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746
220341014045	Protein of unknown function (DUF3438); Region: DUF3438; pfam11920
220341014046	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
220341014047	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
220341014048	conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751
220341014049	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341014050	PS00017 ATP/GTP-binding site motif A (P-loop)
220341014051	integrating conjugative element protein, PFL_4709 family; Region: conj_TIGR03757
220341014052	integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756
220341014053	integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755
220341014054	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
220341014055	Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969
220341014056	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
220341014057	Active Sites [active]
220341014058	Domain of unknown function (DUF3440); Region: DUF3440; pfam11922
220341014059	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
220341014060	ParB-like nuclease domain; Region: ParB; smart00470
220341014061	Phage integrase, N-terminal; Region: Phage_int_SAM_2; pfam12834
220341014062	Integrase; Region: Integrase_1; pfam12835
220341014063	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
220341014064	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
220341014065	Protein of unknown function (DUF1219); Region: DUF1219; pfam06755
220341014066	Protein of unknown function (DUF3085); Region: DUF3085; pfam11284
220341014067	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
220341014068	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
220341014069	active site
220341014070	DNA binding site [nucleotide binding]
220341014071	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
220341014072	phage insertion point. Note this sequence is duplicated at position 4507385..4507393
220341014073	bacteriophage
220341014074	Ogr/Delta-like zinc finger; Region: Ogr_Delta; cl19592
220341014075	tail protein; Provisional; Region: D; PHA02561
220341014076	Phage protein U [General function prediction only]; Region: COG3499
220341014077	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
220341014078	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050
220341014079	membrane protein P6; Region: PHA01399
220341014080	PS00017 ATP/GTP-binding site motif A (P-loop)
220341014081	Phage P2 GpE; Region: Phage_P2_GpE; pfam06528
220341014082	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
220341014083	major tail tube protein; Provisional; Region: FII; PHA02600
220341014084	major tail sheath protein; Provisional; Region: FI; PHA02560
220341014085	type III secretion protein SopE; Provisional; Region: PRK15279
220341014086	Salmonella type III secretion SopE effector N-terminus; Region: SecIII_SopE_N; pfam05364
220341014087	SopE GEF domain; Region: SopE_GEF; pfam07487
220341014088	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
220341014089	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
220341014090	Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385
220341014091	baseplate assembly protein; Provisional; Region: J; PHA02568
220341014092	baseplate wedge subunit; Provisional; Region: W; PHA02516
220341014093	Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540
220341014094	Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069
220341014095	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
220341014096	phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495
220341014097	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
220341014098	catalytic residues [active]
220341014099	Transmembrane protein 223; Region: TMEM223; pfam14640
220341014100	P2-like prophage tail protein X [General function prediction only]; Region: COG5004
220341014101	Phage head completion protein (GPL); Region: Phage_GPL; pfam05926
220341014102	PS00017 ATP/GTP-binding site motif A (P-loop)
220341014103	terminase endonuclease subunit; Provisional; Region: M; PHA02537
220341014104	capsid protein; Provisional; Region: N; PHA02538
220341014105	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838
220341014106	terminase ATPase subunit; Provisional; Region: P; PHA02535
220341014107	Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056
220341014108	Phage Terminase; Region: Terminase_1; cl19862
220341014109	portal vertex protein; Provisional; Region: Q; PHA02536
220341014110	Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840
220341014111	DNA adenine methylase (dam); Region: dam; TIGR00571
220341014112	PS00092 N-6 Adenine-specific DNA methylases signature
220341014113	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
220341014114	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
220341014115	active site
220341014116	catalytic site [active]
220341014117	substrate binding site [chemical binding]; other site
220341014118	DksA-like zinc finger domain containing protein; Region: PHA00080
220341014119	Protein of unknown function (DUF2732); Region: DUF2732; pfam10809
220341014120	Protein of unknown function (DUF2724); Region: DUF2724; pfam10893
220341014121	Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892
220341014122	Predicted transcriptional regulator [Transcription]; Region: COG2932
220341014123	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
220341014124	integrase; Provisional; Region: int; PHA02601
220341014125	Leucine carboxyl methyltransferase; Region: LCM; cl01306
220341014126	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
220341014127	active site
220341014128	DNA binding site [nucleotide binding]
220341014129	Int/Topo IB signature motif; other site
220341014130	phage insertion point. Note this sequence is duplicated at position 4473830..4473838
220341014131	hypothetical protein; Provisional; Region: PRK13687
220341014132	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
220341014133	S-adenosylmethionine binding site [chemical binding]; other site
220341014134	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
220341014135	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
220341014136	S-adenosylmethionine binding site [chemical binding]; other site
220341014137	Vi polysaccharide export protein VexE; Provisional; Region: PRK15174
220341014138	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
220341014139	TPR motif; other site
220341014140	binding surface
220341014141	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
220341014142	putative acyl-acceptor binding pocket; other site
220341014143	Vi polysaccharide export inner membrane protein VexD; Provisional; Region: PRK15178
220341014144	polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010
220341014145	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
220341014146	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
220341014147	Walker A/P-loop; other site
220341014148	ATP binding site [chemical binding]; other site
220341014149	Q-loop/lid; other site
220341014150	ABC transporter signature motif; other site
220341014151	Walker B; other site
220341014152	D-loop; other site
220341014153	H-loop/switch region; other site
220341014154	PS00017 ATP/GTP-binding site motif A (P-loop)
220341014155	Vi polysaccharide export inner membrane protein VexB; Provisional; Region: PRK15176
220341014156	PS00890 ABC-2 type transport system integral membrane proteins signature
220341014157	Vi polysaccharide export protein VexA; Provisional; Region: PRK15175
220341014158	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
220341014159	PS00013 Prokaryotic membrane lipoprotein lipid attachment site
220341014160	Vi polysaccharide biosynthesis protein TviE; Provisional; Region: PRK15490
220341014161	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
220341014162	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
220341014163	IS1 transposase; Region: DDE_Tnp_IS1; pfam03400
220341014164	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
220341014165	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
220341014166	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
220341014167	Vi polysaccharide biosynthesis protein TviD; Provisional; Region: PRK15180
220341014168	Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181
220341014169	UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256
220341014170	NAD binding site [chemical binding]; other site
220341014171	substrate binding site [chemical binding]; other site
220341014172	homodimer interface [polypeptide binding]; other site
220341014173	active site
220341014174	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
220341014175	UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721
220341014176	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
220341014177	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
220341014178	Vi polysaccharide biosynthesis protein TviA; Provisional; Region: PRK15183
220341014179	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
220341014180	AAA domain; Region: AAA_22; pfam13401
220341014181	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
220341014182	PS00017 ATP/GTP-binding site motif A (P-loop)
220341014183	Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_1; cl12235
220341014184	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
220341014185	active site
220341014186	catalytic residues [active]
220341014187	DNA binding site [nucleotide binding]
220341014188	Int/Topo IB signature motif; other site
220341014189	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
220341014190	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
220341014191	Coenzyme A binding pocket [chemical binding]; other site
220341014192	PS00017 ATP/GTP-binding site motif A (P-loop)
220341014193	Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423
220341014194	Phage integrase, N-terminal; Region: Phage_int_SAM_2; pfam12834
220341014195	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
220341014196	active site
220341014197	Int/Topo IB signature motif; other site
220341014198	catalytic residues [active]
220341014199	DNA binding site [nucleotide binding]
220341014200	integrase; Provisional; Region: PRK09692
220341014201	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
220341014202	active site
220341014203	Int/Topo IB signature motif; other site
220341014204	putative transcriptional regulator; Provisional; Region: PRK11640
220341014205	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
220341014206	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
220341014207	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
220341014208	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
220341014209	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
220341014210	DsbD alpha interface [polypeptide binding]; other site
220341014211	catalytic residues [active]
220341014212	PS00194 Thioredoxin family active site
220341014213	divalent-cation tolerance protein CutA; Provisional; Region: PRK10645
220341014214	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
220341014215	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
220341014216	Aspartase; Region: Aspartase; cd01357
220341014217	active sites [active]
220341014218	tetramer interface [polypeptide binding]; other site
220341014219	PS00163 Fumarate lyases signature
220341014220	Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030
220341014221	putative transporter; Provisional; Region: PRK11021
220341014222	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
220341014223	oligomerisation interface [polypeptide binding]; other site
220341014224	mobile loop; other site
220341014225	roof hairpin; other site
220341014226	PS00681 Chaperonins cpn10 signature
220341014227	chaperonin GroEL; Reviewed; Region: groEL; PRK12850
220341014228	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
220341014229	ring oligomerisation interface [polypeptide binding]; other site
220341014230	ATP/Mg binding site [chemical binding]; other site
220341014231	stacking interactions; other site
220341014232	hinge regions; other site
220341014233	PS00296 Chaperonins cpn60 signature
220341014234	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
220341014235	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
220341014236	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
220341014237	FeS/SAM binding site; other site
220341014238	elongation factor P; Validated; Region: PRK00529
220341014239	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
220341014240	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
220341014241	RNA binding site [nucleotide binding]; other site
220341014242	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
220341014243	RNA binding site [nucleotide binding]; other site
220341014244	PS01275 Elongation factor P signature
220341014245	Predicted small secreted protein [Function unknown]; Region: COG5510
220341014246	entericidin B membrane lipoprotein; Provisional; Region: PRK10081
220341014247	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
220341014248	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
220341014249	DNA binding residues [nucleotide binding]
220341014250	dimerization interface [polypeptide binding]; other site
220341014251	PS00622 Bacterial regulatory proteins, luxR family signature
220341014252	PS00017 ATP/GTP-binding site motif A (P-loop)
220341014253	multidrug efflux system protein; Provisional; Region: PRK11431
220341014254	outer membrane lipoprotein Blc; Provisional; Region: PRK10477
220341014255	PS00225 Crystallins beta and gamma 'Greek key' motif signature
220341014256	PS00213 Lipocalin signature
220341014257	Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547
220341014258	Iron-sulfur protein interface; other site
220341014259	proximal quinone binding site [chemical binding]; other site
220341014260	C-subunit interface; other site
220341014261	distal quinone binding site; other site
220341014262	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2
220341014263	Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546
220341014264	D-subunit interface [polypeptide binding]; other site
220341014265	Iron-sulfur protein interface; other site
220341014266	proximal quinone binding site [chemical binding]; other site
220341014267	distal quinone binding site [chemical binding]; other site
220341014268	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385
220341014269	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
220341014270	catalytic loop [active]
220341014271	iron binding site [ion binding]; other site
220341014272	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
220341014273	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341014274	PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature
220341014275	fumarate reductase flavoprotein subunit; Validated; Region: PRK09231
220341014276	L-aspartate oxidase; Provisional; Region: PRK06175
220341014277	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
220341014278	PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site
220341014279	poxB regulator PoxA; Provisional; Region: PRK09350
220341014280	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
220341014281	motif 1; other site
220341014282	dimer interface [polypeptide binding]; other site
220341014283	active site
220341014284	motif 2; other site
220341014285	motif 3; other site
220341014286	PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1
220341014287	PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2
220341014288	inner membrane transporter YjeM; Provisional; Region: PRK15238
220341014289	putative mechanosensitive channel protein; Provisional; Region: PRK10929
220341014290	Mu-like prophage I protein; Region: Mu-like_Pro; cl19864
220341014291	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
220341014292	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
220341014293	Mechanosensitive ion channel; Region: MS_channel; pfam00924
220341014294	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
220341014295	GTPase RsgA; Reviewed; Region: PRK12288
220341014296	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
220341014297	RNA binding site [nucleotide binding]; other site
220341014298	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
220341014299	GTPase/Zn-binding domain interface [polypeptide binding]; other site
220341014300	GTP/Mg2+ binding site [chemical binding]; other site
220341014301	G4 box; other site
220341014302	G5 box; other site
220341014303	G1 box; other site
220341014304	Switch I region; other site
220341014305	G2 box; other site
220341014306	G3 box; other site
220341014307	Switch II region; other site
220341014308	PS00017 ATP/GTP-binding site motif A (P-loop)
220341014309	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
220341014310	catalytic site [active]
220341014311	putative active site [active]
220341014312	putative substrate binding site [chemical binding]; other site
220341014313	dimer interface [polypeptide binding]; other site
220341014314	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
220341014315	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
220341014316	substrate binding pocket [chemical binding]; other site
220341014317	membrane-bound complex binding site; other site
220341014318	hinge residues; other site
220341014319	PS01039 Bacterial extracellular solute-binding proteins, family 3 signature
220341014320	epoxyqueuosine reductase; Region: TIGR00276
220341014321	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
220341014322	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
220341014323	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341014324	putative carbohydrate kinase; Provisional; Region: PRK10565
220341014325	Uncharacterized conserved protein [Function unknown]; Region: COG0062
220341014326	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
220341014327	putative substrate binding site [chemical binding]; other site
220341014328	putative ATP binding site [chemical binding]; other site
220341014329	ADP-binding protein; Provisional; Region: PRK10646
220341014330	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
220341014331	PS00017 ATP/GTP-binding site motif A (P-loop)
220341014332	N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431
220341014333	AMIN domain; Region: AMIN; pfam11741
220341014334	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
220341014335	active site
220341014336	metal binding site [ion binding]; metal-binding site
220341014337	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
220341014338	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
220341014339	ATP binding site [chemical binding]; other site
220341014340	Mg2+ binding site [ion binding]; other site
220341014341	G-X-G motif; other site
220341014342	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
220341014343	ATP binding site [chemical binding]; other site
220341014344	MutL C terminal dimerization domain; Region: MutL_C; pfam08676
220341014345	PS00058 DNA mismatch repair proteins mutL / hexB / PMS1 signature
220341014346	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
220341014347	PS00017 ATP/GTP-binding site motif A (P-loop)
220341014348	bacterial Hfq-like; Region: Hfq; cd01716
220341014349	hexamer interface [polypeptide binding]; other site
220341014350	Sm1 motif; other site
220341014351	RNA binding site [nucleotide binding]; other site
220341014352	Sm2 motif; other site
220341014353	GTPase HflX; Provisional; Region: PRK11058
220341014354	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
220341014355	HflX GTPase family; Region: HflX; cd01878
220341014356	G1 box; other site
220341014357	GTP/Mg2+ binding site [chemical binding]; other site
220341014358	Switch I region; other site
220341014359	G2 box; other site
220341014360	G3 box; other site
220341014361	Switch II region; other site
220341014362	G4 box; other site
220341014363	G5 box; other site
220341014364	PS00017 ATP/GTP-binding site motif A (P-loop)
220341014365	FtsH protease regulator HflK; Provisional; Region: PRK10930
220341014366	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
220341014367	High frequency of lysogenization K (HflK) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflK; cd03404
220341014368	HflC protein; Region: hflC; TIGR01932
220341014369	High frequency of lysogenization C (HflC) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflC; cd03405
220341014370	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242
220341014371	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
220341014372	GDP-binding site [chemical binding]; other site
220341014373	ACT binding site; other site
220341014374	IMP binding site; other site
220341014375	PS01266 Adenylosuccinate synthetase GTP-binding site
220341014376	PS00513 Adenylosuccinate synthetase active site
220341014377	transcriptional repressor NsrR; Provisional; Region: PRK11014
220341014378	Rrf2 family protein; Region: rrf2_super; TIGR00738
220341014379	exoribonuclease R; Provisional; Region: PRK11642
220341014380	Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461
220341014381	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
220341014382	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
220341014383	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
220341014384	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
220341014385	RNA binding site [nucleotide binding]; other site
220341014386	PS01175 Ribonuclease II family signature
220341014387	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
220341014388	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
220341014389	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
220341014390	Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551
220341014391	Protein of unknown function (DUF2491); Region: DUF2491; pfam10679
220341014392	Predicted membrane protein [Function unknown]; Region: COG3766
220341014393	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
220341014394	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
220341014395	Predicted integral membrane protein [Function unknown]; Region: COG5463
220341014396	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
220341014397	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
220341014398	Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154
220341014399	FAD binding site [chemical binding]; other site
220341014400	substrate binding site [chemical binding]; other site
220341014401	catalytic residues [active]
220341014402	PS00072 Acyl-CoA dehydrogenases signature 1
220341014403	PS00073 Acyl-CoA dehydrogenases signature 2
220341014404	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
220341014405	putative biofilm stress and motility protein A; Provisional; Region: PRK14864
220341014406	esterase; Provisional; Region: PRK10566
220341014407	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
220341014408	transcriptional repressor UlaR; Provisional; Region: PRK13509
220341014409	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
220341014410	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
220341014411	PS00894 Bacterial regulatory proteins, deoR family signature
220341014412	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
220341014413	Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037
220341014414	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
220341014415	active site
220341014416	P-loop; other site
220341014417	phosphorylation site [posttranslational modification]
220341014418	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
220341014419	active site
220341014420	phosphorylation site [posttranslational modification]
220341014421	PS00387 Inorganic pyrophosphatase signature
220341014422	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
220341014423	active site
220341014424	dimer interface [polypeptide binding]; other site
220341014425	magnesium binding site [ion binding]; other site
220341014426	L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209
220341014427	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
220341014428	AP (apurinic/apyrimidinic) site pocket; other site
220341014429	DNA interaction; other site
220341014430	Metal-binding active site; metal-binding site
220341014431	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
220341014432	intersubunit interface [polypeptide binding]; other site
220341014433	active site
220341014434	Zn2+ binding site [ion binding]; other site
220341014435	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
220341014436	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
220341014437	PS01048 Ribosomal protein S6 signature
220341014438	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
220341014439	dimer interface [polypeptide binding]; other site
220341014440	ssDNA binding site [nucleotide binding]; other site
220341014441	tetramer (dimer of dimers) interface [polypeptide binding]; other site
220341014442	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
220341014443	PS00057 Ribosomal protein S18 signature
220341014444	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
220341014445	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
220341014446	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
220341014447	PS00651 Ribosomal protein L9 signature
220341014448	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
220341014449	EamA-like transporter family; Region: EamA; pfam00892
220341014450	EamA-like transporter family; Region: EamA; pfam00892
220341014451	Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061
220341014452	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
220341014453	peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570
220341014454	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
220341014455	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
220341014456	PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1
220341014457	PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2
220341014458	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
220341014459	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
220341014460	PS00218 Amino acid permeases signature
220341014461	DKNYY family; Region: DKNYY; pfam13644
220341014462	DKNYY family; Region: DKNYY; pfam13644
220341014463	iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992
220341014464	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
220341014465	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
220341014466	Fe binding site [ion binding]; other site
220341014467	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
220341014468	EamA-like transporter family; Region: EamA; pfam00892
220341014469	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
220341014470	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
220341014471	NADP binding site [chemical binding]; other site
220341014472	Predicted transcriptional regulators [Transcription]; Region: COG1733
220341014473	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
220341014474	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
220341014475	active site
220341014476	metal binding site [ion binding]; metal-binding site
220341014477	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
220341014478	PS00786 5'-nucleotidase signature 2
220341014479	PS00785 5'-nucleotidase signature 1
220341014480	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
220341014481	active site
220341014482	PS00629 Inositol monophosphatase family signature 1
220341014483	PS00630 Inositol monophosphatase family signature 2
220341014484	Predicted transcriptional regulator [General function prediction only]; Region: COG3054
220341014485	Protein of unknown function (DUF1107); Region: DUF1107; pfam06526
220341014486	IS200
220341014487	Transposase IS200 like; Region: Y1_Tnp; pfam01797
220341014488	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
220341014489	Domain of unknown function DUF21; Region: DUF21; pfam01595
220341014490	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
220341014491	Transporter associated domain; Region: CorC_HlyC; smart01091
220341014492	methionine sulfoxide reductase A; Provisional; Region: PRK00058
220341014493	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
220341014494	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
220341014495	Surface antigen; Region: Bac_surface_Ag; pfam01103
220341014496	PS00213 Lipocalin signature
220341014497	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
220341014498	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
220341014499	Family of unknown function (DUF490); Region: DUF490; pfam04357
220341014500	PS00213 Lipocalin signature
220341014501	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
220341014502	putative active site pocket [active]
220341014503	dimerization interface [polypeptide binding]; other site
220341014504	putative catalytic residue [active]
220341014505	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341014506	D-galactonate transporter; Region: 2A0114; TIGR00893
220341014507	putative substrate translocation pore; other site
220341014508	putative metallo-dependent hydrolase; Provisional; Region: PRK12394
220341014509	Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307
220341014510	active site
220341014511	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
220341014512	dimer interface [polypeptide binding]; other site
220341014513	substrate binding site [chemical binding]; other site
220341014514	metal binding sites [ion binding]; metal-binding site
220341014515	PS00387 Inorganic pyrophosphatase signature
220341014516	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
220341014517	AMP binding site [chemical binding]; other site
220341014518	metal binding site [ion binding]; metal-binding site
220341014519	active site
220341014520	PS00124 Fructose-1-6-bisphosphatase active site
220341014521	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
220341014522	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
220341014523	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
220341014524	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
220341014525	hypothetical protein; Provisional; Region: PRK05255
220341014526	peptidase PmbA; Provisional; Region: PRK11040
220341014527	cytochrome b562; Provisional; Region: PRK15058
220341014528	PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582
220341014529	Glycine-rich SFCGS; Region: Gly_rich_SFCGS; pfam14272
220341014530	conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578
220341014531	conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580
220341014532	Domain of unknown function (DUF4310); Region: DUF4310; pfam14187
220341014533	probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583
220341014534	Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307
220341014535	active site
220341014536	uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437
220341014537	conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581
220341014538	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
220341014539	HTH domain; Region: HTH_11; pfam08279
220341014540	Mga helix-turn-helix domain; Region: Mga; pfam05043
220341014541	PRD domain; Region: PRD; pfam00874
220341014542	PRD domain; Region: PRD; pfam00874
220341014543	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
220341014544	active site
220341014545	P-loop; other site
220341014546	phosphorylation site [posttranslational modification]
220341014547	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
220341014548	active site
220341014549	phosphorylation site [posttranslational modification]
220341014550	PS00894 Bacterial regulatory proteins, deoR family signature
220341014551	PS00372 PTS EIIA domains phosphorylation site signature 2
220341014552	bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235
220341014553	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
220341014554	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
220341014555	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
220341014556	FeS/SAM binding site; other site
220341014557	PS01087 Radical activating enzymes signature
220341014558	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
220341014559	ATP cone domain; Region: ATP-cone; pfam03477
220341014560	Class III ribonucleotide reductase; Region: RNR_III; cd01675
220341014561	effector binding site; other site
220341014562	active site
220341014563	Zn binding site [ion binding]; other site
220341014564	glycine loop; other site
220341014565	PS00850 Glycine radical signature
220341014566	trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933
220341014567	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
220341014568	Ca binding site [ion binding]; other site
220341014569	active site
220341014570	catalytic site [active]
220341014571	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
220341014572	PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007
220341014573	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
220341014574	active site turn [active]
220341014575	phosphorylation site [posttranslational modification]
220341014576	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
220341014577	PS01035 PTS EIIB domains cysteine phosphorylation site signature
220341014578	trehalose repressor; Provisional; Region: treR; PRK09492
220341014579	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
220341014580	DNA binding site [nucleotide binding]
220341014581	domain linker motif; other site
220341014582	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
220341014583	dimerization interface [polypeptide binding]; other site
220341014584	ligand binding site [chemical binding]; other site
220341014585	PS00356 Bacterial regulatory proteins, lacI family signature
220341014586	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
220341014587	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
220341014588	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
220341014589	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
220341014590	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
220341014591	motif II; other site
220341014592	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
220341014593	PS00154 E1-E2 ATPases phosphorylation site
220341014594	Transposase; Region: HTH_Tnp_1; cl17663
220341014595	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
220341014596	homotrimer interaction site [polypeptide binding]; other site
220341014597	putative active site [active]
220341014598	PS01094 Uncharacterized protein family UPF0076 signature
220341014599	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
220341014600	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
220341014601	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
220341014602	aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670
220341014603	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
220341014604	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
220341014605	PS00097 Aspartate and ornithine carbamoyltransferases signature
220341014606	pyrBI operon leader peptide; Provisional; Region: PRK10224
220341014607	Arginine repressor [Transcription]; Region: ArgR; COG1438
220341014608	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
220341014609	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
220341014610	Predicted membrane protein [Function unknown]; Region: COG1288
220341014611	ornithine carbamoyltransferase; Validated; Region: PRK02102
220341014612	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
220341014613	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
220341014614	PS00097 Aspartate and ornithine carbamoyltransferases signature
220341014615	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
220341014616	putative substrate binding site [chemical binding]; other site
220341014617	nucleotide binding site [chemical binding]; other site
220341014618	nucleotide binding site [chemical binding]; other site
220341014619	homodimer interface [polypeptide binding]; other site
220341014620	arginine deiminase; Provisional; Region: PRK01388
220341014621	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
220341014622	ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515
220341014623	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
220341014624	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
220341014625	PS00097 Aspartate and ornithine carbamoyltransferases signature
220341014626	RNase E inhibitor protein; Provisional; Region: PRK11191
220341014627	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
220341014628	active site
220341014629	dinuclear metal binding site [ion binding]; other site
220341014630	dimerization interface [polypeptide binding]; other site
220341014631	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
220341014632	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
220341014633	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
220341014634	Coenzyme A binding pocket [chemical binding]; other site
220341014635	Predicted membrane protein [Function unknown]; Region: COG4269
220341014636	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
220341014637	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
220341014638	active site
220341014639	HIGH motif; other site
220341014640	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
220341014641	KMSKS motif; other site
220341014642	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
220341014643	tRNA binding surface [nucleotide binding]; other site
220341014644	anticodon binding site; other site
220341014645	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
220341014646	PS00178 Aminoacyl-transfer RNA synthetases class-I signature
220341014647	DNA polymerase III subunit chi; Validated; Region: PRK05728
220341014648	multifunctional aminopeptidase A; Provisional; Region: PRK00913
220341014649	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
220341014650	interface (dimer of trimers) [polypeptide binding]; other site
220341014651	Substrate-binding/catalytic site; other site
220341014652	Zn-binding sites [ion binding]; other site
220341014653	PS00631 Cytosol aminopeptidase signature
220341014654	lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120
220341014655	lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071
220341014656	gluconate operon transcriptional regulator; Provisional; Region: PRK14987
220341014657	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
220341014658	DNA binding site [nucleotide binding]
220341014659	domain linker motif; other site
220341014660	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
220341014661	putative dimerization interface [polypeptide binding]; other site
220341014662	putative ligand binding site [chemical binding]; other site
220341014663	PS00356 Bacterial regulatory proteins, lacI family signature
220341014665	PS00059 Zinc-containing alcohol dehydrogenases signature
220341014666	PS00190 Cytochrome c family heme-binding site signature
220341014667	Salmonella Pathogenicity Island 10. Carries bacteriophage P4 containg genes encoding serine/threonine kinases. The SPI also carries genes associated with virulence plasmids of Salmonella typhimurium and Salmonella enteritidis. Salmonella typhimurium has a different Pathogenicity Island inserted at the same locus.
220341014668	degenerate bacteriophage P4.
220341014669	integrase; Provisional; Region: PRK09692
220341014670	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
220341014671	active site
220341014672	Int/Topo IB signature motif; other site
220341014673	Catalytic domain of Protein Kinases; Region: PKc; cd00180
220341014674	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
220341014675	active site
220341014676	ATP binding site [chemical binding]; other site
220341014677	substrate binding site [chemical binding]; other site
220341014678	activation loop (A-loop); other site
220341014679	PS00108 Serine/Threonine protein kinases active-site signature
220341014680	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
220341014681	Catalytic domain of Protein Kinases; Region: PKc; cd00180
220341014682	active site
220341014683	ATP binding site [chemical binding]; other site
220341014684	substrate binding site [chemical binding]; other site
220341014685	activation loop (A-loop); other site
220341014686	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
220341014687	active site
220341014688	Phage polarity suppression protein (Psu); Region: Psu; pfam07455
220341014689	Ogr/Delta-like zinc finger; Region: Ogr_Delta; cl19592
220341014690	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
220341014691	Oxygenase, catalyzing oxidative methylation of damaged DNA; Region: Oxygenase-NA; cl17606
220341014692	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
220341014693	Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778
220341014694	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
220341014695	active site
220341014696	metal binding site [ion binding]; metal-binding site
220341014697	interdomain interaction site; other site
220341014698	D5 N terminal like; Region: D5_N; smart00885
220341014699	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
220341014700	PS00017 ATP/GTP-binding site motif A (P-loop)
220341014701	DNA repeat, similar to 4694767..4694857. 75.6% identity in 90 nt overlap
220341014702	DNA repeat, similar to 4694599..4694689. 75.6% identity in 90 nt overlap
220341014703	putative fimbrial chaperone protein SefB; Provisional; Region: PRK15233
220341014704	Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345
220341014705	Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753
220341014706	PS00635 Gram-negative pili assembly chaperone signature
220341014707	outer membrane fimbrial usher protein SefC; Provisional; Region: PRK15235
220341014708	PapC N-terminal domain; Region: PapC_N; pfam13954
220341014709	Outer membrane usher protein; Region: Usher; pfam00577
220341014710	PapC C-terminal domain; Region: PapC_C; pfam13953
220341014711	PS00041 Bacterial regulatory proteins, araC family signature
220341014712	FaeA-like protein; Region: FaeA; pfam04703
220341014713	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
220341014714	DNA binding residues [nucleotide binding]
220341014715	dimerization interface [polypeptide binding]; other site
220341014716	SdiA-regulated; Region: SdiA-regulated; cd09971
220341014717	putative active site [active]
220341014718	Putative transposase pseudogene. Similar to Yersinia pestis putative transposase YPCD1.94 TR:Q9RI05 (EMBL:AL117189) (269 aa) fasta scores: E(): 0, 50.9% id in 273 aa, and to Enterobacter agglomerans IS 1222 gene ORF-A and ORF-B TR:Q46612 (EMBL:X78052) (276 aa) fasta scores: E(): 1.1e-25, 35.5% id in 262 aa. Contains a frameshift around codon 88.
220341014719	PS00017 ATP/GTP-binding site motif A (P-loop)
220341014720	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440
220341014721	HNH endonuclease; Region: HNH_2; pfam13391
220341014722	hypothetical protein; Provisional; Region: PRK12378
220341014723	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
220341014724	S-adenosylmethionine binding site [chemical binding]; other site
220341014725	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
220341014726	S-adenosylmethionine binding site [chemical binding]; other site
220341014727	hypothetical protein; Provisional; Region: PRK13687
220341014728	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4332
220341014729	Uncharacterized conserved protein [Function unknown]; Region: COG3439
220341014730	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
220341014731	PS00120 Lipases
220341014732	DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225
220341014733	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
220341014734	DNA-binding site [nucleotide binding]; DNA binding site
220341014735	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
220341014736	PS00043 Bacterial regulatory proteins, gntR family signature
220341014737	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
220341014738	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
220341014739	active site
220341014740	HIGH motif; other site
220341014741	dimer interface [polypeptide binding]; other site
220341014742	KMSKS motif; other site
220341014743	PS00178 Aminoacyl-transfer RNA synthetases class-I signature
220341014744	Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion,    and vesicular transport]; Region: Hcp; COG3157
220341014745	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
220341014746	PS00923 Aspartate and glutamate racemases signature 1
220341014747	PS00924 Aspartate and glutamate racemases signature 2
220341014748	cell density-dependent motility repressor; Provisional; Region: PRK10082
220341014749	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341014750	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
220341014751	dimerization interface [polypeptide binding]; other site
220341014752	PS00044 Bacterial regulatory proteins, lysR family signature
220341014753	isoaspartyl dipeptidase; Provisional; Region: PRK10657
220341014754	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
220341014755	active site
220341014756	hypothetical protein; Provisional; Region: PRK10519
220341014757	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
220341014758	Nucleoside recognition; Region: Gate; pfam07670
220341014759	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341014760	Major Facilitator Superfamily; Region: MFS_1; pfam07690
220341014761	putative substrate translocation pore; other site
220341014762	Predicted membrane protein [Function unknown]; Region: COG2733
220341014763	Protein of unknown function (DUF445); Region: DUF445; pfam04286
220341014764	multidrug efflux system protein MdtM; Provisional; Region: PRK15403
220341014765	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341014766	putative substrate translocation pore; other site
220341014767	PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site
220341014768	PS00216 Sugar transport proteins signature 1
220341014769	hypothetical protein; Provisional; Region: PRK09956
220341014770	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
220341014771	PS00687 Aldehyde dehydrogenases glutamic acid active site
220341014772	PS00070 Aldehyde dehydrogenases cysteine active site
220341014773	endoribonuclease SymE; Provisional; Region: PRK13605
220341014774	EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737
220341014775	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
220341014776	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
220341014777	PS00092 N-6 Adenine-specific DNA methylases signature
220341014778	type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448
220341014779	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
220341014780	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
220341014781	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
220341014782	ATP binding site [chemical binding]; other site
220341014783	putative Mg++ binding site [ion binding]; other site
220341014784	Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271
220341014785	EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463
220341014786	PS00215 Mitochondrial energy transfer proteins signature
220341014787	PS00017 ATP/GTP-binding site motif A (P-loop)
220341014788	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
220341014789	Mrr N-terminal domain; Region: Mrr_N; pfam14338
220341014790	Restriction endonuclease; Region: Mrr_cat; pfam04471
220341014791	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929
220341014792	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514
220341014793	putative GTP-binding protein YjiA; Provisional; Region: PRK11537
220341014794	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
220341014795	P-loop, Walker A motif; other site
220341014796	Base recognition motif; other site
220341014797	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
220341014798	PS00017 ATP/GTP-binding site motif A (P-loop)
220341014799	Uncharacterized small protein [Function unknown]; Region: COG2879
220341014800	carbon starvation protein A; Provisional; Region: PRK15015
220341014801	Carbon starvation protein CstA; Region: CstA; pfam02554
220341014802	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
220341014803	PS00538 Bacterial chemotaxis sensory transducers signature
220341014804	phosphoglycerol transferase I; Provisional; Region: PRK03776
220341014805	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
220341014806	hypothetical protein; Provisional; Region: PRK11667
220341014807	DNA replication protein DnaC; Validated; Region: PRK07952
220341014808	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
220341014809	Walker A motif; other site
220341014810	ATP binding site [chemical binding]; other site
220341014811	Walker B motif; other site
220341014812	primosomal protein DnaI; Provisional; Region: PRK02854
220341014813	hypothetical protein; Provisional; Region: PRK09917
220341014814	Uncharacterized conserved protein [Function unknown]; Region: COG2966
220341014815	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
220341014816	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
220341014817	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
220341014818	DNA binding residues [nucleotide binding]
220341014819	dimerization interface [polypeptide binding]; other site
220341014820	DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475
220341014821	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
220341014822	DNA binding residues [nucleotide binding]
220341014823	dimerization interface [polypeptide binding]; other site
220341014824	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
220341014825	putative deacylase active site [active]
220341014826	ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647
220341014827	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
220341014828	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
220341014829	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
220341014830	metal binding site [ion binding]; metal-binding site
220341014831	active site
220341014832	I-site; other site
220341014833	Protein of unknown function (DUF1435); Region: DUF1435; pfam07256
220341014834	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
220341014835	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
220341014836	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
220341014837	S-adenosylmethionine binding site [chemical binding]; other site
220341014838	DNA polymerase III subunit psi; Validated; Region: PRK06856
220341014839	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
220341014840	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
220341014841	Coenzyme A binding pocket [chemical binding]; other site
220341014842	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
220341014843	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
220341014844	motif II; other site
220341014845	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
220341014846	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
220341014847	G1 box; other site
220341014848	putative GEF interaction site [polypeptide binding]; other site
220341014849	GTP/Mg2+ binding site [chemical binding]; other site
220341014850	Switch I region; other site
220341014851	G2 box; other site
220341014852	G3 box; other site
220341014853	Switch II region; other site
220341014854	G4 box; other site
220341014855	G5 box; other site
220341014856	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
220341014857	Elongation Factor G, domain II; Region: EFG_II; pfam14492
220341014858	PS00301 GTP-binding elongation factors signature
220341014859	periplasmic protein; Provisional; Region: PRK10568
220341014860	BON domain; Region: BON; pfam04972
220341014861	BON domain; Region: BON; pfam04972
220341014862	Small integral membrane protein [Function unknown]; Region: COG5487
220341014863	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
220341014864	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
220341014865	active site
220341014866	nucleophile elbow; other site
220341014867	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
220341014868	active site
220341014869	PS01137 Uncharacterized protein family UPF0006 signature 1
220341014870	PS01090 Uncharacterized protein family UPF0006 signature 2
220341014871	glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041
220341014872	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
220341014873	FeS/SAM binding site; other site
220341014874	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
220341014875	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341014876	PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature
220341014877	PS01087 Radical activating enzymes signature
220341014878	PS00190 Cytochrome c family heme-binding site signature
220341014879	hypothetical protein; Provisional; Region: PRK10977
220341014880	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
220341014881	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
220341014882	intersubunit interface [polypeptide binding]; other site
220341014883	active site
220341014884	catalytic residue [active]
220341014885	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
220341014886	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
220341014887	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
220341014888	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
220341014889	PS00647 Thymidine and pyrimidine-nucleoside phosphorylases signature
220341014890	phosphopentomutase; Provisional; Region: PRK05362
220341014891	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
220341014892	PS01232 Purine and other phosphorylases family 1 signature
220341014893	PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature
220341014894	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
220341014895	lipoate-protein ligase A; Provisional; Region: lplA; PRK03822
220341014896	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
220341014897	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
220341014898	hypothetical protein; Provisional; Region: PRK11246
220341014899	phosphoserine phosphatase; Provisional; Region: serB; PRK11133
220341014900	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
220341014901	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
220341014902	motif II; other site
220341014903	DNA repair protein RadA; Region: sms; TIGR00416
220341014904	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
220341014905	Walker A motif/ATP binding site; other site
220341014906	ATP binding site [chemical binding]; other site
220341014907	Walker B motif; other site
220341014908	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
220341014909	PS00017 ATP/GTP-binding site motif A (P-loop)
220341014910	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
220341014911	non-specific DNA binding site [nucleotide binding]; other site
220341014912	salt bridge; other site
220341014913	bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099
220341014914	sequence-specific DNA binding site [nucleotide binding]; other site
220341014915	Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167
220341014916	active site
220341014917	(T/H)XGH motif; other site
220341014918	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
220341014919	PS00017 ATP/GTP-binding site motif A (P-loop)
220341014920	PS00687 Aldehyde dehydrogenases glutamic acid active site
220341014921	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
220341014922	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
220341014923	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
220341014924	ABC transporter; Region: ABC_tran_2; pfam12848
220341014925	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
220341014926	PS00017 ATP/GTP-binding site motif A (P-loop)
220341014927	PS00211 ABC transporters family signature
220341014928	PS00017 ATP/GTP-binding site motif A (P-loop)
220341014929	lytic murein transglycosylase; Provisional; Region: PRK11619
220341014930	Soluble lytic murein transglycosylase L domain; Region: SLT_L; pfam14718
220341014931	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
220341014932	N-acetyl-D-glucosamine binding site [chemical binding]; other site
220341014933	catalytic residue [active]
220341014934	PS00922 Prokaryotic transglycosylases signature
220341014935	Trp operon repressor; Provisional; Region: PRK01381
220341014937	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
220341014938	catalytic core [active]
220341014939	PS00175 Phosphoglycerate mutase family phosphohistidine signature
220341014940	right oriC-binding transcriptional activator; Provisional; Region: PRK15121
220341014941	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341014942	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
220341014943	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
220341014944	PS00041 Bacterial regulatory proteins, araC family signature
220341014945	hypothetical protein; Provisional; Region: PRK10756
220341014946	DNA-binding response regulator CreB; Provisional; Region: PRK11083
220341014947	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
220341014948	active site
220341014949	phosphorylation site [posttranslational modification]
220341014950	intermolecular recognition site; other site
220341014951	dimerization interface [polypeptide binding]; other site
220341014952	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
220341014953	DNA binding site [nucleotide binding]
220341014954	sensory histidine kinase CreC; Provisional; Region: PRK11100
220341014955	Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827
220341014956	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
220341014957	dimerization interface [polypeptide binding]; other site
220341014958	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
220341014959	dimer interface [polypeptide binding]; other site
220341014960	phosphorylation site [posttranslational modification]
220341014961	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
220341014962	ATP binding site [chemical binding]; other site
220341014963	Mg2+ binding site [ion binding]; other site
220341014964	G-X-G motif; other site
220341014965	Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452
220341014966	putative fimbrial protein SthD; Provisional; Region: PRK15293
220341014967	PS01151 Fimbrial biogenesis outer membrane usher protein signature
220341014968	fimbrial assembly chaperone SthB; Provisional; Region: PRK15295
220341014969	Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345
220341014970	Pili assembly chaperone PapD, C-terminal domain; Region: PapD_C; pfam02753
220341014971	PS00635 Gram-negative pili assembly chaperone signature
220341014972	putative fimbrial protein SthA; Provisional; Region: PRK15296
220341014973	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832
220341014974	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
220341014975	two-component response regulator; Provisional; Region: PRK11173
220341014976	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
220341014977	active site
220341014978	phosphorylation site [posttranslational modification]
220341014979	intermolecular recognition site; other site
220341014980	dimerization interface [polypeptide binding]; other site
220341014981	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
220341014982	DNA binding site [nucleotide binding]
220341014983	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
220341014984	putative RNA methyltransferase; Provisional; Region: PRK10433
220341014985	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
220341014986	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
220341014987	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
220341014988	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
220341014989	possible translational frameshift site, similar to that determined experimentally (EMBL:X52534)
220341014990	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
220341014991	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
220341014992	Cl binding site [ion binding]; other site
220341014993	oligomer interface [polypeptide binding]; other site
220341014994	Predicted periplasmic protein (DUF2233); Region: DUF2233; cl19845
220341014995	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
220341014996	Protein of unknown function (DUF3085); Region: DUF3085; pfam11284
220341014997	Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117
220341014998	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
220341014999	active site
220341015000	ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020
220341015001	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
220341015002	Active Sites [active]
220341015003	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
220341015004	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
220341015005	U1 small nuclear ribonucleoprotein of 70kDa MW N terminal; Region: U1snRNP70_N; pfam12220
220341015006	Domain of unknown function (DUF4165); Region: DUF4165; pfam13752
220341015007	Bacterial Ig-like domain (group 3); Region: Big_3_2; pfam12245
220341015008	Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750
220341015009	extent of possible pseudogene
220341015010	Domain of unknown function (DUF4165); Region: DUF4165; pfam13752
220341015011	Protein of unknown function (DUF3607); Region: DUF3607; pfam12245
220341015012	Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750
220341015013	Initiator Replication protein; Region: Rep_3; cl03080
220341015014	Domain of unknown function (DUF4165); Region: DUF4165; pfam13752
220341015015	Bacterial Ig-like domain (group 3); Region: Big_3_2; pfam12245
220341015016	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
220341015017	Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750
220341015018	CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cd09672
220341015019	Methyltransferase domain; Region: Methyltransf_27; pfam13708
220341015020	Methyltransferase domain; Region: Methyltransf_26; pfam13659
220341015021	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
220341015022	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
220341015023	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cl19048
220341015024	Initiator Replication protein; Region: Rep_3; cl17676
220341015025	TraL protein; Region: TraL; cl06278
220341015026	TraE protein; Region: TraE; cl05060
220341015027	TraK protein; Region: TraK; cl05878
220341015028	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
220341015029	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
220341015030	Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; cl19474
220341015031	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
220341015032	type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746
220341015033	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
220341015034	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
220341015035	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
220341015036	P-loop; other site
220341015037	Magnesium ion binding site [ion binding]; other site
220341015038	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
220341015039	ParB-like nuclease domain; Region: ParB; smart00470
220341015040	ParB family; Region: ParB; pfam08775
220341015041	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
220341015042	active site
220341015043	metal binding site [ion binding]; metal-binding site
220341015044	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
220341015045	Mg binding site [ion binding]; other site
220341015046	nucleotide binding site [chemical binding]; other site
220341015047	putative protofilament interface [polypeptide binding]; other site
220341015048	Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750
220341015049	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
220341015050	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
220341015051	Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673
220341015052	Sex factor F TraW protein N terminal; Region: TraW_N; cl10149
220341015053	TraU protein; Region: TraU; pfam06834
220341015054	conjugal transfer mating pair stabilization protein TraN; Provisional; Region: PRK14877
220341015055	Competence protein CoiA-like family; Region: CoiA; cl11541
220341015056	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
220341015057	Part of AAA domain; Region: AAA_19; pfam13245
220341015058	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
220341015059	similar to type I restriction; contains frameshifts
220341015060	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
220341015061	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
220341015062	ATP binding site [chemical binding]; other site
220341015063	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
220341015064	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
220341015065	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
220341015066	Walker A motif; other site
220341015067	ATP binding site [chemical binding]; other site
220341015068	Walker B motif; other site
220341015069	Protein of unknown function (DUF3150); Region: DUF3150; pfam11348
220341015070	Serine-rich region of AP3B1, clathrin-adaptor complex; Region: SEEEED; cl19208
220341015071	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
220341015072	metal ion-dependent adhesion site (MIDAS); other site
220341015073	Toprim domain; Region: Toprim_3; pfam13362
220341015074	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632
220341015075	DNA replication terminus site-binding protein (Ter protein); Region: Ter; pfam05472
220341015076	Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799
220341015077	DNA binding site [nucleotide binding]
220341015078	dimer interface [polypeptide binding]; other site
220341015079	active site
220341015080	Int/Topo IB signature motif; other site
220341015081	Haemolysin expression modulating protein; Region: HHA; pfam05321
220341015082	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
220341015083	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
220341015084	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
220341015085	IS1 transposase; Region: DDE_Tnp_IS1; pfam03400
220341015086	possible translational frameshift site, similar to that determined experimentally (EMBL:X52534)
220341015087	similar to transposase
220341015088	replication protein; Provisional; Region: PRK13742
220341015089	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
220341015090	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
220341015091	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
220341015092	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
220341015093	possible translational frameshift site, similar to that determined experimentally (EMBL:X52534)
220341015094	putative transcriptional regulator MerR; Provisional; Region: PRK13752
220341015095	Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783
220341015096	DNA binding residues [nucleotide binding]
220341015097	dimer interface [polypeptide binding]; other site
220341015098	mercury binding site [ion binding]; other site
220341015099	putative mercuric transport protein; Provisional; Region: PRK13751
220341015100	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
220341015101	metal-binding site [ion binding]
220341015102	putative mercury transport protein MerC; Provisional; Region: PRK13755
220341015103	putative mercuric reductase; Provisional; Region: PRK13748
220341015104	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
220341015105	metal-binding site [ion binding]
220341015106	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
220341015107	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
220341015108	transcriptional regulator MerD; Provisional; Region: PRK13749
220341015109	Helix-Turn-Helix DNA binding domain of the MerD transcription regulator; Region: HTH_MerD; cd01111
220341015110	DNA binding residues [nucleotide binding]
220341015111	putative dimer interface [polypeptide binding]; other site
220341015112	putative mercury resistance protein; Provisional; Region: PRK13747
220341015113	Domain of unknown function (DUF3330); Region: DUF3330; pfam11809
220341015114	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
220341015115	Integrase core domain; Region: rve; pfam00665
220341015116	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
220341015117	folate binding site [chemical binding]; other site
220341015118	NADP+ binding site [chemical binding]; other site
220341015119	similar to aminoglycoside acetyltransferase (EMBL:U12338) aacC1 from Pseudomonas aeruginosa plasmid R1033; contains frameshifts
220341015120	integrase/recombinase; Provisional; Region: PRK15417
220341015121	IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193
220341015122	Int/Topo IB signature motif; other site
220341015123	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
220341015124	multiple promoter invertase; Provisional; Region: mpi; PRK13413
220341015125	catalytic residues [active]
220341015126	catalytic nucleophile [active]
220341015127	Presynaptic Site I dimer interface [polypeptide binding]; other site
220341015128	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
220341015129	Synaptic Flat tetramer interface [polypeptide binding]; other site
220341015130	Synaptic Site I dimer interface [polypeptide binding]; other site
220341015131	DNA binding site [nucleotide binding]
220341015132	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569
220341015133	DNA-binding interface [nucleotide binding]; DNA binding site
220341015134	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
220341015135	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
220341015136	similar to (EMBL:Z48244) Yersinia enterocolitica transposase for insertion sequence element IS1328
220341015137	HNH endonuclease; Region: HNH_2; pfam13391
220341015138	HNH endonuclease; Region: HNH_2; pfam13391
220341015139	Domain in histone-like proteins of HNS family; Region: HNS; cl19571
220341015140	DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328
220341015141	Methyltransferase domain; Region: Methyltransf_27; pfam13708
220341015142	Methyltransferase domain; Region: Methyltransf_27; pfam13708
220341015143	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
220341015144	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
220341015145	Protein of unknown function (DUF1173); Region: DUF1173; pfam06666
220341015146	DNA cytosine methylase; Provisional; Region: PRK10458
220341015147	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
220341015148	cofactor binding site; other site
220341015149	DNA binding site [nucleotide binding]
220341015150	substrate interaction site [chemical binding]; other site
220341015151	Staphylococcal nuclease homologues; Region: SNc; smart00318
220341015152	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
220341015153	Catalytic site; other site
220341015154	Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176
220341015155	PLD-like domain; Region: PLDc_2; pfam13091
220341015156	putative homodimer interface [polypeptide binding]; other site
220341015157	putative active site [active]
220341015158	catalytic site [active]
220341015159	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
220341015160	similar to endolysin
220341015161	Winged helix-turn helix; Region: HTH_29; pfam13551
220341015162	Helix-turn-helix domain; Region: HTH_28; pfam13518
220341015163	Homeodomain-like domain; Region: HTH_32; pfam13565
220341015164	Integrase core domain; Region: rve; pfam00665
220341015165	Domain of unknown function (DUF4263); Region: DUF4263; pfam14082
220341015166	IS1 transposase; Region: DDE_Tnp_IS1; pfam03400
220341015167	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
220341015168	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
220341015169	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
220341015170	possible translational frameshift site, similar to that determined experimentally (EMBL:X52534)
220341015171	chloramphenicol acetyltransferase; Provisional; Region: PRK13757
220341015172	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
220341015173	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
220341015174	Transposase; Region: DEDD_Tnp_IS110; pfam01548
220341015175	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
220341015176	similar to (EMBL:X04891) tnpA from Escherichia coli transposon TN21; N-terminus is truncated
220341015177	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
220341015178	Transposase; Region: HTH_Tnp_1; cl17663
220341015179	Integrase core domain; Region: rve; pfam00665
220341015180	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
220341015181	Transposase; Region: HTH_Tnp_1; cl17663
220341015182	Integrase core domain; Region: rve; pfam00665
220341015183	similar to (EMBL:M55547) tnpR from Klebsiella pneumoniae transposon Tn1331 from plasmid pJHC-MW1
220341015184	beta-lactamase TEM; Provisional; Region: PRK15442
220341015185	similar to (EMBL:L06418) sulI from Escherichia coli plasmid pDGO100
220341015186	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
220341015187	Transposase; Region: HTH_Tnp_1; cl17663
220341015188	Integrase core domain; Region: rve; pfam00665
220341015189	similar to (EMBL:M28829) repA from Escherichia coli plasmid IncQ RSF1010; N-terminus is truncated
220341015190	Replication initiator protein A; Region: RPA; cl19398
220341015191	Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294
220341015192	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
220341015193	substrate binding pocket [chemical binding]; other site
220341015194	dimer interface [polypeptide binding]; other site
220341015195	inhibitor binding site; inhibition site
220341015196	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
220341015197	Phosphotransferase enzyme family; Region: APH; pfam01636
220341015198	active site
220341015199	ATP binding site [chemical binding]; other site
220341015200	antibiotic binding site [chemical binding]; other site
220341015201	Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; pfam04655
220341015202	similar to (EMBL:U42226) tniA from Shigella flexneri plasmid R100; truncated at the C-terminus
220341015203	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
220341015204	putative mercury resistance protein; Provisional; Region: PRK13747
220341015205	transcriptional regulator MerD; Provisional; Region: PRK13749
220341015206	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
220341015207	DNA binding residues [nucleotide binding]
220341015208	putative mercuric reductase; Provisional; Region: PRK13748
220341015209	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
220341015210	metal-binding site [ion binding]
220341015211	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
220341015212	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
220341015213	putative mercury transport protein MerC; Provisional; Region: PRK13755
220341015214	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
220341015215	metal-binding site [ion binding]
220341015216	putative mercuric transport protein; Provisional; Region: PRK13751
220341015217	putative transcriptional regulator MerR; Provisional; Region: PRK13752
220341015218	Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783
220341015219	DNA binding residues [nucleotide binding]
220341015220	dimer interface [polypeptide binding]; other site
220341015221	mercury binding site [ion binding]; other site
220341015222	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
220341015223	Transposase; Region: DEDD_Tnp_IS110; pfam01548
220341015224	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
220341015225	IS1 transposase; Region: DDE_Tnp_IS1; pfam03400
220341015226	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
220341015227	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
220341015228	InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759
220341015229	possible translational frameshift site, similar to that determined experimentally (EMBL:X52534)
220341015230	similar to (EMBL:J01830) tetC from Escherichia coli transposon Tn10 protein; truncated at the N-terminus
220341015231	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
220341015232	Major Facilitator Superfamily; Region: MFS_1; pfam07690
220341015233	putative substrate translocation pore; other site
220341015234	tetracycline repressor protein TetR; Provisional; Region: PRK13756
220341015235	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
220341015236	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
220341015237	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
220341015238	dimerization interface [polypeptide binding]; other site
220341015239	putative DNA binding site [nucleotide binding]; other site
220341015240	putative Zn2+ binding site [ion binding]; other site
220341015241	ACT domain-containing protein [General function prediction only]; Region: COG4747
220341015242	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
220341015243	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
220341015244	similar to (EMBL:D00626) gltS from Escherichia coli; contains frameshifts
220341015245	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
220341015246	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
220341015247	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
220341015248	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
220341015249	Catalytic site [active]
220341015250	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
220341015251	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
220341015252	active site
220341015253	DNA binding site [nucleotide binding]
220341015254	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
220341015255	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
220341015256	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
220341015257	catalytic residues [active]
220341015258	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
220341015259	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
220341015260	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
220341015261	dimerization domain [polypeptide binding]; other site
220341015262	dimer interface [polypeptide binding]; other site
220341015263	catalytic residues [active]
220341015264	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
220341015265	N-acetyl-D-glucosamine binding site [chemical binding]; other site
220341015266	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
220341015267	Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122
220341015268	TraF-like protein; Region: TraF-like; TIGR02740
220341015269	Putative helicase; Region: TraI_2; pfam07514
220341015270	Brain acid soluble protein 1 (BASP1 protein); Region: BASP1; pfam05466
220341015271	Domain of unknown function DUF87; Region: DUF87; cl19135
220341015272	AAA-like domain; Region: AAA_10; pfam12846
220341015273	Domain of unknown function (DUF4400); Region: DUF4400; pfam14348
220341015274	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
220341015275	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
220341015276	tandem repeat interface [polypeptide binding]; other site
220341015277	oligomer interface [polypeptide binding]; other site
220341015278	active site residues [active]
220341015279	Nuclease-related domain; Region: NERD; pfam08378
220341015280	Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006
220341015281	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
220341015282	Procyclic acidic repetitive protein (PARP); Region: Trypan_PARP; pfam05887
220341015283	possible pseudogene; may change frame at {g}8 suggesting that this CDS is subject to slipped-strand mispairing
220341015284	small toxic polypeptide; Provisional; Region: PRK09738
220341015285	hypothetical protein; Region: PHA02053
220341015286	Protein of unknown function (DUF2591); Region: DUF2591; pfam10765
220341015287	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
220341015288	SPFH domain / Band 7 family; Region: Band_7; pfam01145
220341015289	RNA polymerase recycling family C-terminal; Region: RapA_C; pfam12137
220341015290	RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468
220341015291	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
220341015292	Walker A motif; other site
220341015293	ATP binding site [chemical binding]; other site
220341015294	Walker B motif; other site
220341015295	PIN domain of bacteriophage T3, T4 RNase H, T5-5'nuclease, and homologs; Region: PIN_T4-like; cd09860
220341015296	5'-3' exonuclease; Region: 53EXOc; smart00475
220341015297	active site
220341015298	metal binding site 1 [ion binding]; metal-binding site
220341015299	5' ssDNA interaction site; other site
220341015300	3' ssDNA interaction site; other site
220341015301	metal binding site 2 [ion binding]; metal-binding site
220341015302	H3TH domain of bacteriophage T3, T4 RNase H, T5-5' nucleases, and homologs; Region: H3TH_T4-like; cd09899
220341015303	DNA binding site [nucleotide binding]
220341015304	metal binding site [ion binding]; metal-binding site
220341015305	PHP domain; Region: PHP; pfam02811
220341015306	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
220341015307	active site
220341015308	PHP Thumb interface [polypeptide binding]; other site
220341015309	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
220341015310	Helix-hairpin-helix motif; Region: HHH_6; pfam14579
220341015311	Uracil DNA glycosylase superfamily; Region: UDG; pfam03167
220341015312	MoxR-like ATPases [General function prediction only]; Region: COG0714
220341015313	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
220341015314	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
220341015315	Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase) [Coenzyme metabolism]; Region: CobT; COG4547
220341015316	Hyaluronan / mRNA binding family; Region: HABP4_PAI-RBP1; pfam04774
220341015317	Cobalamin biosynthesis protein CobT VWA domain; Region: CobT_C; pfam11775
220341015318	metal ion-dependent adhesion site (MIDAS); other site
220341015319	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
220341015320	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
220341015321	active site
220341015322	DNA binding site [nucleotide binding]
220341015323	Int/Topo IB signature motif; other site
220341015324	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
220341015325	GSH binding site [chemical binding]; other site
220341015326	catalytic residues [active]
220341015327	hypothetical protein; Region: PHA01971
220341015328	hypothetical protein; Provisional; Region: PRK10536
220341015329	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
220341015330	Prominin; Region: Prominin; pfam05478
220341015331	DNA ligase; Provisional; Region: 30; PHA02587
220341015332	Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896
220341015333	DNA binding site [nucleotide binding]
220341015334	active site
220341015335	The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase_family; cl08424
220341015336	DNA binding site [nucleotide binding]
220341015337	dihydrolipoamide dehydrogenase; Validated; Region: PRK06292
220341015338	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
220341015339	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
220341015340	active site
220341015341	metal binding site [ion binding]; metal-binding site
220341015342	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
220341015343	Walker A motif; other site
220341015344	ATP binding site [chemical binding]; other site
220341015345	Walker B motif; other site
220341015346	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
220341015347	ParA-like protein; Provisional; Region: PHA02518
220341015348	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
220341015349	P-loop; other site
220341015350	Magnesium ion binding site [ion binding]; other site
220341015351	virion protein; Provisional; Region: V; PHA02564
220341015352	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
220341015353	Phage-related protein, tail component [Function unknown]; Region: COG4733
220341015354	Putative phage tail protein; Region: Phage-tail_3; pfam13550
220341015355	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
220341015356	Interdomain contacts; other site
220341015357	Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820
220341015358	fibritin; Provisional; Region: wac; PHA02607
220341015359	Domain of unknown function (DUF1983); Region: DUF1983; pfam09327
220341015360	Fibronectin type III protein; Region: DUF3672; pfam12421
220341015361	Phage-related protein, tail component [Function unknown]; Region: COG4723
220341015362	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073
220341015363	MPN+ (JAMM) motif; other site
220341015364	Zinc-binding site [ion binding]; other site
220341015365	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
220341015366	NlpC/P60 family; Region: NLPC_P60; pfam00877
220341015367	lambda-like phage minor tail protein L; Region: phage_tail_L; TIGR01600
220341015368	Phage-related protein [Function unknown]; Region: COG4718
220341015369	Mu-like prophage protein [General function prediction only]; Region: COG3941
220341015370	tape measure domain; Region: tape_meas_nterm; TIGR02675
220341015371	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
220341015372	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
220341015373	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718
220341015374	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
220341015375	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
220341015376	flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793
220341015377	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
220341015378	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
220341015379	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
220341015380	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
220341015381	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
220341015382	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
220341015383	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; cl19531
220341015384	Phage terminase large subunit; Region: Terminase_3; cl12054
220341015385	Terminase-like family; Region: Terminase_6; pfam03237
220341015386	ABC-type ATPase fused to a predicted acetyltransferase domain [General function prediction only]; Region: COG2401
220341015387	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
220341015388	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
220341015389	Walker A/P-loop; other site
220341015390	ATP binding site [chemical binding]; other site
220341015391	ABC transporter signature motif; other site
220341015392	Walker B; other site
220341015393	D-loop; other site
220341015394	H-loop/switch region; other site
220341015395	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
220341015396	ParB-like nuclease domain; Region: ParBc; pfam02195
220341015397	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
220341015398	ParB-like nuclease domain; Region: ParBc; pfam02195
220341015399	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
220341015400	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
220341015401	ATP binding site [chemical binding]; other site
220341015402	putative Mg++ binding site [ion binding]; other site
220341015403	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
220341015404	nucleotide binding region [chemical binding]; other site
220341015405	ATP-binding site [chemical binding]; other site
220341015406	Protein of unknown function (DUF2846); Region: DUF2846; pfam11008
220341015407	Repressor of phase-1 flagellin; Region: Flag1_repress; pfam03614
220341015408	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
220341015409	Exocyst complex component Sec10; Region: Sec10; pfam07393
220341015410	YdfZ protein; Region: YdfZ; pfam14001
220341015411	HD domain; Region: HD_4; pfam13328
220341015412	Methyltransferase domain; Region: Methyltransf_27; pfam13708
220341015413	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
220341015414	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
220341015415	Phage antirepressor protein KilAC domain; Region: ANT; cl01462
220341015416	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
220341015417	RNA/DNA hybrid binding site [nucleotide binding]; other site
220341015418	active site
220341015419	DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869
220341015420	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
220341015421	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
220341015422	active site
220341015423	catalytic site [active]
220341015424	substrate binding site [chemical binding]; other site
220341015425	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
220341015426	AAA domain; Region: AAA_17; pfam13207
220341015427	active site
220341015428	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
220341015429	folate binding site [chemical binding]; other site
220341015430	NADP+ binding site [chemical binding]; other site
220341015431	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
220341015432	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
220341015433	dimerization interface [polypeptide binding]; other site
220341015434	active site
220341015435	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530
220341015436	metal binding site [ion binding]; metal-binding site
220341015437	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
220341015438	metal binding site [ion binding]; metal-binding site
220341015439	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
220341015440	dimer interface [polypeptide binding]; other site
220341015441	putative radical transfer pathway; other site
220341015442	diiron center [ion binding]; other site
220341015443	tyrosyl radical; other site
220341015444	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103
220341015445	ATP cone domain; Region: ATP-cone; pfam03477
220341015446	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
220341015447	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
220341015448	endonuclease subunit; Provisional; Region: 46; PHA02562
220341015449	Walker A/P-loop; other site
220341015450	ATP binding site [chemical binding]; other site
220341015451	Q-loop/lid; other site
220341015452	ABC transporter signature motif; other site
220341015453	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
220341015454	ABC transporter signature motif; other site
220341015455	Walker B; other site
220341015456	D-loop; other site
220341015457	H-loop/switch region; other site
220341015458	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
220341015459	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
220341015460	active site
220341015461	metal binding site [ion binding]; metal-binding site
220341015462	T-complex protein 10 C-terminus; Region: Tcp10_C; pfam07202
220341015463	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
220341015464	Coenzyme A binding pocket [chemical binding]; other site
220341015465	Initiator Replication protein; Region: Rep_3; pfam01051